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https://www.readbyqxmd.com/read/29138501/targeting-sxip-eb1-interaction-an-integrated-approach-to-the-discovery-of-small-molecule-modulators-of-dynamic-binding-sites
#1
T B Almeida, A J Carnell, I L Barsukov, N G Berry
End binding protein 1 (EB1) is a key element in the complex network of protein-protein interactions at microtubule (MT) growing ends, which has a fundamental role in MT polymerisation. EB1 is an important protein target as it is involved in regulating MT dynamic behaviour, and has been associated with several disease states, such as cancer and neuronal diseases. Diverse EB1 binding partners are recognised through a conserved four amino acid motif, (serine-X-isoleucine-proline) which exists within an intrinsically disordered region...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137660/optimising-the-value-of-the-evidence-generated-in-implementation-science-the-use-of-ontologies-to-address-the-challenges
#2
EDITORIAL
Susan Michie, Marie Johnston
Implementing research findings into healthcare practice and policy is a complex process occurring in diverse contexts; it invariably depends on changing human behaviour in many parts of an intricate implementation system. Questions asked with the aim of improving implementation are multifarious variants of 'What works, compared with what, how well, with what exposure, with what behaviours (for how long), for whom, in what setting and why?'. Relevant evidence is being published at a high rate, but its quantity, complexity and lack of shared terminologies present challenges...
November 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29136879/development-and-evaluation-of-a-new-diffusive-gradients-in-thin-films-technique-for-measuring-organotin-compounds-in-coastal-sediment-pore-water
#3
Russell F Cole, Graham A Mills, Michelle S Hale, Ruth Parker, Thi Bolam, Peter R Teasdale, William W Bennett, Gary R Fones
Organotins present a toxicological risk to biota in the aquatic environment. Understanding the behaviour of these compounds in sediment is challenging, with sophisticated analytical techniques required for their measurement. We investigated the use of silica-bound sorbents for diffusive gradients in thin-films (DGT) adsorption gels to pre-concentrate five organotins (monobutlytin (MBT), dibutyltin (DBT), tributyltin (TBT), diphenyltin (DPhT), triphenyltin (TPhT)) found frequently in coastal sediment. C8 sorbent showed optimum performance in uptake and recovery of organotins for pH and ionic strength ranges typical of coastal waters...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136228/opioid-prescription-use-in-nursing-home-residents-with-advanced-dementia
#4
Charlotte Griffioen, Bettina S Husebo, Elisabeth Flo, Monique A A Caljouw, Wilco P Achterberg
Background: Although proper pain treatment may require opioids, discussion continues about possible undertreatment or overtreatment in persons with advanced dementia. Objective: To investigate the prevalence of pain, frequency of opioid prescription use, and factors associated with strong opioid prescription use in nursing homes. Design: Cross-sectional study. Setting and Subjects: Eighteen Norwegian nursing homes; 327 persons with advanced dementia and behavioral disturbances participated...
November 9, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29134104/king-post-truss-as-a-motif-for-internal-structure-of-meta-material-with-controlled-elastic-properties
#5
Emilio Turco, Ivan Giorgio, Anil Misra, Francesco dell'Isola
One of the most interesting challenges in the modern theory of materials consists in the determination of those microstructures which produce, at the macro-level, a class of metamaterials whose elastic range is many orders of magnitude wider than the one exhibited by 'standard' materials. In dell'Isola et al. (2015 Zeitschrift für angewandte Mathematik und Physik66, 3473-3498. (doi:10.1007/s00033-015-0556-4)), it was proved that, with a pantographic microstructure constituted by 'long' micro-beams it is possible to obtain metamaterials whose elastic range spans up to an elongation exceeding 30%...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133138/contextual-factors-and-motivations-affecting-rural-community-sanitation-in-low-and-middle-income-countries-a-systematic-review
#6
REVIEW
Josef Novotný, Jiří Hasman, Martin Lepič
BACKGROUND: Unsafe management of human faecal waste represents a major risk for public health, particularly in low- and middle-income countries. Efforts to improve sanitation conditions are considerably sensitive to contextual specifics of natural and social environments. This review operationalises, analyses, and synthesises evidence of how contextual factors and motivations affect different sanitation outcomes with a specific focus on community approaches to rural sanitation. METHODS AND FINDINGS: We operationalised contextual factors and motivations as determinants that influence sanitation conditions independently of the examined intervention...
November 6, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29132291/hiv-prevention-needs-for-men-who-have-sex-with-men-in-swaziland
#7
Bhekie Sithole
Men who have sex with men (MSM) have a high HIV burden and also often face multiple other challenges accessing HIV services, including legal and social issues. Although Swaziland recently started responding with interventions for MSM, significant gaps still exist both in information and programming. This study aimed to explore the HIV prevention needs of MSM in Swaziland, including factors elevating their risks and vulnerabilities to HIV infection; to find out what HIV prevention strategies exist; and to determine how best to meet the prevention needs of MSM...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29130644/progress-towards-the-united-nations-90-90-90-and-95-95-95-targets-the-experience-in-british-columbia-canada
#8
Viviane D Lima, Martin St-Jean, Ignacio Rozada, Jean A Shoveller, Bohdan Nosyk, Robert S Hogg, Paul Sereda, Rolando Barrios, Julio S G Montaner
INTRODUCTION: Antiretroviral therapy (ART) scale-up is central to the global strategy to control the HIV/AIDS pandemic. To accelerate efforts towards ending the AIDS epidemic, the Joint United Nations Programme on HIV/AIDS released the 90-90-90 and 95-95-95 targets, which have recently been approved by the United Nations (UN). This study characterizes the province of British Columbia (BC)'s progress towards achieving the UN targets, predicts a trajectory up to 2030 according to each of the individual steps (i...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29130030/a-review-of-engineered-zirconia-surfaces-in-biomedical-applications
#9
Ling Yin, Yoshitaka Nakanishi, Abdur-Rasheed Alao, Xiao-Fei Song, Jaafar Abduo, Yu Zhang
Zirconia is widely used for load-bearing functional structures in medicine and dentistry. The quality of engineered zirconia surfaces determines not only the fracture and fatigue behaviour but also the low temperature degradation (ageing sensitivity), bacterial colonization and bonding strength of zirconia devices. This paper reviews the current manufacturing techniques for fabrication of zirconia surfaces in biomedical applications, particularly, in tooth and joint replacements, and influences of the zirconia surface quality on their functional behaviours...
2017: Procedia CIRP
https://www.readbyqxmd.com/read/29129115/innovative-layer-genetics-to-handle-global-challenges-in-egg-production
#10
R Preisinger
1. In commercial layer breeding, extensive gene pools are tested and selected for market requirements which must be anticipated at least five years ahead. Field results confirm a continuous positive genetic trend in egg output and better feed efficiency which can be converted into land savings. 2. Animal welfare and cage-free housing dominate future needs of the market. Nesting behaviour and minimal tendency to develop feather-pecking or cannibalism without beak treatment, are key trait complexes. Stronger shells for longer production cycles without moulting have to be combined with better bones...
November 13, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29128445/the-promise-of-induced-pluripotent-stem-cells-for-neurodevelopmental-disorders
#11
REVIEW
Katrin Linda, Carol Fiuza, Nael Nadif Kasri
A major challenge in clinical genetics and medicine is represented by genetically and phenotypically highly diverse neurodevelopmental disorders, like for example intellectual disability and autism. Intellectual disability is characterized by substantial limitations in cognitive function and adaptive behaviour. At the cellular level, this is reflected by deficits in synaptic structure and plasticity and therefore has been coined as a synaptic disorder or "synaptopathy". In this review, we summarize the findings from recent studies in which iPSCs have been used to model specific neurodevelopmental syndromes, including Fragile X syndrome, Rett syndrome, Williams-Beuren syndrome and Phelan-McDermid syndrome...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128304/symptoms-of-mental-illness-and-their-impact-on-managing-type-2-diabetes-in-adults
#12
Adriana Cimo, Carolyn S Dewa
OBJECTIVES: People with mental illnesses are more likely to experience diabetes-related complications that can reduce life expectancy by 10 to 15 years. Diabetes management and outcomes can be improved when lifestyle interventions addressing healthful eating habits and physical activity use content tailored to the learning needs of individuals or groups. Understanding the challenges that prevent adherence to diabetes recommendations can start to inform the design of tailored diabetes education care...
November 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29127978/-virtual-doctors-and-e-health
#13
Pierre Philip, Stéphanie Bioulac, Étienne de Sevin, Jean-Arthur Micoulaud-Franchi
One of the challenges of e-health will be to give concrete form to personalised therapeutic solutions using connected objects, information and decision-making systems, and patient management behavioural programmes. Developed to improve the empathetic relationship with patients, virtual companions are the subject of research programmes.
November 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/29127852/social-interaction-and-pain-an-arctic-expedition
#14
Per Block, Lauren C Heathcote, Stephanie Burnett Heyes
Complex human behaviour can only be understood within its social environment. However, disentangling the causal links between individual outcomes and social network position is empirically challenging. We present a research design in a closed real-world setting with high-resolution temporal data to understand this interplay within a fundamental human experience - physical pain. Study participants completed an isolated 3-week hiking expedition in the Arctic Circle during which they were subject to the same variation in environmental conditions and only interacted amongst themselves...
November 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29126870/susceptibility-to-unconscious-influences-is-unaffected-by-a-challenging-inhibitory-task-or-mental-exhaustion
#15
Angela Gurney, Anna-Nepheli L Lagos, Abigail Manning, Ryan B Scott
Unconscious influences have been demonstrated in a variety of behavioural contexts, however, a key question remains - to what extent do such influences vary with our changing mental states? We examine whether a prior inhibitory challenge increases susceptibility to subliminal priming in a stem completion task employing neutral (Experiment 1) and reward salient terms (Experiment 2). Results show stem completions to be significantly influenced by unconscious priming, and the challenging inhibitory task (the Stroop) to be significantly more mentally exhausting than the control task...
November 7, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29126671/treatment-challenges-in-and-outside-a-specialist-network-setting-pancreatic-neuroendocrine-tumours
#16
Panagis M Lykoudis, Stefano Partelli, Francesca Muffatti, Martyn Caplin, Massimo Falconi, Giuseppe K Fusai
Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements. The specialized biochemical tests and radiological investigations, the complexity of surgical options and the variety of medical treatments that require individual tailoring, mandate a multidisciplinary approach that can be optimally achieved through an organized network. The present study describes currents concepts in the management of these tumours as well as an insight into the challenges of delivering the pathway in and outside a Network...
October 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29126610/building-evaluative-culture-in-community-services-caring-for-evidence
#17
John Mayne
An organization with a strong evaluative culture engages in self-reflection, evidence-based learning and experimentation. It sees evidence as essential for managing well, but building such a culture is challenging. Community service organizations seek to provide effective services for their clients. To build an evaluative culture, they need to acquire basic monitoring and evaluation capabilities, be provided with opportunities for using these capabilities and be adequately motivated to care about evidence as a means to improve services to their clients...
May 25, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29126094/evolutionarily-adapted-hormesis-inducing-stressors-can-be-a-practical-solution-to-mitigate-harmful-effects-of-chronic-exposure-to-low-dose-chemical-mixtures
#18
REVIEW
Se-A Kim, Yu-Mi Lee, Je-Yong Choi, David R Jacobs, Duk-Hee Lee
Although the toxicity of synthetic chemicals at high doses is well known, chronic exposure to low-dose chemical mixtures has only recently been linked to many age-related diseases. However, it is nearly impossible to avoid the exposure to these low-dose chemical mixtures as humans are exposed to a myriad of synthetic chemicals as a part of their daily lives. Therefore, coping with possible harms due to low dose chemical mixtures is challenging. Interestingly, within the range of environmental exposure, disease risk does not increase linearly with increasing dose of chemicals, but often tends to plateau or even decrease with increasing dose...
November 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29125324/communication-training-interventions-for-family-and-professional-carers-of-people-living-with-dementia-a-systematic-review-of-effectiveness-acceptability-and-conceptual-basis
#19
L Morris, M Horne, P McEvoy, T Williamson
OBJECTIVES: To update previous reviews and provide a more detailed overview of the effectiveness, acceptability and conceptual basis of communication training-interventions for carers of people living with dementia. METHOD: We searched CINAHL Plus, MEDLINE and PsycINFO using a specific search and extraction protocol, and PRISMA guidelines. Two authors conducted searches and extracted studies that reported effectiveness, efficacy or acceptability data regarding a communication training-intervention for carers of people living with dementia...
November 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29124778/giving-versus-acting-using-latent-profile-analysis-to-distinguish-between-benevolent-and-activist-support-for-global-poverty-reduction
#20
Emma F Thomas, Craig McGarty
There are a variety of ways that people can respond to inequality. This article considers the distinction between collective giving and collective acting, but also adopts a focus on the people who engage in those behaviours. Benevolent supporters engage in efforts to alleviate suffering through the transfer of money or provision of goods ('giving'), while activist supporters engage in actions that aim to challenging an underlying injustice or exploitation ('acting'). Using samples obtained through anti-poverty non-governmental organizations (N = 2,340), latent profile analysis suggested two qualitatively different forms of support for global poverty reduction: a benevolent supporter profile (defined by moderate levels of charitable support) and an activist supporter profile (defined by engagement in a suite of socio-political actions)...
November 9, 2017: British Journal of Social Psychology
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