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https://www.readbyqxmd.com/read/28102619/editorial-making-clinical-trials-smarter-and-more-interesting
#1
EDITORIAL
R M Pasco Fearon
At its heart, the field of child psychology and psychiatry is geared towards using science to develop interventions that promote children's healthy development and treat behavioural and emotional difficulties when they arise. While there have been some successes (e.g. stimulant medication for ADHD, parent training for child conduct problems, Fonagy et al., ) serious challenges lie ahead if we are to achieve reliable and lasting improvements for a larger number of children, and for a broader spectrum of problems...
February 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28102482/the-role-of-text-messaging-in-cardiovascular-risk-factor-optimization
#2
REVIEW
Harry Klimis, Mohammad Ehsan Khan, Cindy Kok, Clara K Chow
PURPOSE OF REVIEW: Many cases of CVD may be avoidable through lowering behavioural risk factors such as smoking and physical inactivity. Mobile health (mHealth) provides a novel opportunity to deliver cardiovascular prevention programs in a format that is potentially scalable. Here, we provide an overview of text messaging-based mHealth interventions in cardiovascular prevention. RECENT FINDINGS: Text messaging-based interventions appear effective on a range of behavioural risk factors and can effect change on multiple risk factors-e...
January 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28101122/start-early-does-social-instability-during-the-pre-and-early-postnatal-development-prepare-male-wild-cavies-for-social-challenge-later-in-life
#3
Katja Siegeler, Lars Lewejohann, Klaus Failing, Norbert Sachser, Sylvia Kaiser
BACKGROUND: The social environment the mother experiences during pregnancy and lactation can powerfully influence the offspring's behavioural profile. Our previous studies in wild cavies show that two different social environments during pregnancy and lactation bring about different behavioural strategies of male offspring later in life: An unstable social environment leads to a behavioural camouflage strategy, hypothesised to be beneficial at times of socially challenging situations...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28100023/frontotemporal-lobar-degeneration-pathogenesis-pathology-and-pathways-to-phenotype
#4
REVIEW
David Ma Mann, Julie S Snowden
Frontotemporal Lobar Degeneration (FTLD) is a clinically, pathologically and genetically heterogeneous group of disorders that affect principally the frontal and temporal lobes of the brain. There are three major associated clinical syndromes, behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA); three principal histologies, involving tau, TDP-43 and FUS proteins; and mutations in three major genes, MAPT, GRN and C9orf72, along with several other less common gene mutations...
January 18, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28098315/a-ph-responsive-wormlike-micellar-system-of-a-noncovalent-interaction-based-surfactant-with-a-tunable-molecular-structure
#5
Wanli Kang, Pengxiang Wang, Haiming Fan, Hongbin Yang, Caili Dai, Xia Yin, Yilu Zhao, Shujun Guo
Responsive wormlike micelles are very useful in a number of applications, whereas it is still challenging to create dramatic viscosity changes in wormlike micellar systems. Here we developed a pH-responsive wormlike micellar system based on a noncovalent constructed surfactant, which is formed by the complexation of N-erucamidopropyl-N,N-dimethylamine (UC22AMPM) and citric acid at the molar ratio of 3 : 1 (EACA). The phase behavior, aggregate microstructure and viscoelasticity of EACA solutions were investigated by macroscopic appearance observation, rheological and cryo-TEM measurements...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28098147/nanoparticle-induced-unusual-melting-and-solidification-behaviours-of-metals
#6
Chao Ma, Lianyi Chen, Chezheng Cao, Xiaochun Li
Effective control of melting and solidification behaviours of materials is significant for numerous applications. It has been a long-standing challenge to increase the melted zone (MZ) depth while shrinking the heat-affected zone (HAZ) size during local melting and solidification of materials. In this paper, nanoparticle-induced unusual melting and solidification behaviours of metals are reported that effectively solve this long-time dilemma. By introduction of Al2O3 nanoparticles, the MZ depth of Ni is increased by 68%, while the corresponding HAZ size is decreased by 67% in laser melting at a pulse energy of 0...
January 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28096279/a-framework-of-comfort-for-practice-an-integrative-review-identifying-the-multiple-influences-on-patients-experience-of-comfort-in-healthcare-settings
#7
REVIEW
Cynthia Wensley, Mari Botti, Ann McKillop, Alan F Merry
PURPOSE: Comfort is central to patient experience but the concept of comfort is poorly defined. This review aims to develop a framework representing patients' complex perspective of comfort to inform practice and guide initiatives to improve the quality of healthcare. DATA SOURCES: CINAHL, MEDLINE Complete, PsycINFO and Google Scholar (November 2016); reference lists of included publications. STUDY SELECTION: Qualitative and theoretical studies advancing knowledge about the concept of comfort in healthcare settings...
January 16, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28094463/network-over-connectivity-differentiates-autism-spectrum-disorder-from-other-developmental-disorders-in-toddlers-a-diffusion-mri-study
#8
E Conti, J Mitra, S Calderoni, K Pannek, K K Shen, A Pagnozzi, S Rose, S Mazzotti, D Scelfo, M Tosetti, F Muratori, G Cioni, A Guzzetta
Advanced connectivity studies in toddlers with Autism Spectrum Disorder (ASD) are increasing and consistently reporting a disruption of brain connectivity. However, most of these studies compare ASD and typically developing subjects, thus providing little information on the specificity of the abnormalities detected in comparison with other developmental disorders (other-DD). We recruited subjects aged below 36 months who received a clinical diagnosis of Neurodevelopmental Disorder (32 ASD and 16 other-DD including intellectual disability and language disorder) according to DSM-IV TR...
January 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28092386/closer-insight-into-the-structure-of-moderate-to-densely-branched-comb-polymers-by-combining-modelling-and-linear-rheological-measurements
#9
Mostafa Ahmadi, Sandie Pioge, Charles-Andre Fustin, Jean-Francois Gohy, Evelyne van Ruymbeke
Synthesis of combs with well-entangled backbones and long branches with high densities has always been a challenge. Steric hindrance frequently leads to coupling of chains and structural imperfections that cannot be easily distinguished by traditional characterization methods. Research studies have therefore tried to use a combination of different methods to obtain more information on the actual microstructures. In this work, a grafting-from approach is used to synthesize poly(n-butyl acrylate) combs using atom transfer radical polymerization (ATRP) in three steps including the synthesis of a backbone, cleavage of protecting groups and growth of side branches...
January 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/28090772/controlled-growth-of-1d-mose2-nanoribbons-with-spatially-modulated-edge-states
#10
Fang Cheng, Hai Xu, Wentao Xu, Pinjia Zhou, Jens Martin, Kian Ping Loh
Two-dimensional (2D) transition metal dichalcogenides (TMDCs) possess interesting one-dimensional (1D) properties at its edges and inversion domain boundaries, where properties markedly different from the 2D-basal plane can be observed, such as 1D-metallicity and charge density waves. Although 2D-TMDCs crystals are widely grown by chemical vapour deposition (CVD), the fabrication of 1D-TMDCs ribbons is challenging due to the difficulty to confine growth in only one direction. Here we report the controlled growth of MoSe2 nanoribbons with aspect ratio >100 by using pre-patterned Se-reconstructions on Au(100)...
January 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28090716/does-item-overlap-render-measured-relationships-between-pain-and-challenging-behaviour-trivial-results-from-a-multicentre-cross-sectional-study-in-13-german-nursing-homes
#11
Patrick Kutschar, Zsuzsa Bauer, Irmela Gnass, Jürgen Osterbrink
Several studies suggest that pain is a trigger for challenging behaviour in older adults with cognitive impairment. However, such measured relationships might be confounded due to item overlap as instruments share similar or identical items. The purpose of this study was to examine whether the frequently observed association between pain and challenging behaviour might be traced back to item overlap. This multicentre cross-sectional study was conducted in 13 nursing homes and examined pain (measure: Pain Assessment in Advanced Dementia Scale) and challenging behaviour (measure: Cohen-Mansfield Agitation Inventory) in 150 residents with severe cognitive impairment...
January 16, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28090687/prevalence-of-psychotropic-medication-use-and-association-with-challenging-behaviour-in-adults-with-an-intellectual-disability-a-total-population-study
#12
D L Bowring, V Totsika, R P Hastings, S Toogood, M McMahon
BACKGROUND: There is a high prevalence of psychotropic medication use in adults with Intellectual Disabilities (ID), often in the absence of psychiatric disorder, also associated with challenging behaviour. Previous research has focused on specific sample frames or data from primary care providers. There is also a lack of consistency in the definition of challenging behaviour used. METHODS: We adopted a total population sampling method. Medication data on 265 adults with ID were classified according to the Anatomical Therapeutic Chemical classification system...
January 16, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28088206/comparing-accelerometer-pedometer-and-a-questionnaire-for-measuring-physical-activity-in-bronchiectasis-a-validity-and-feasibility-study
#13
B O'Neill, S M McDonough, J J Wilson, I Bradbury, K Hayes, A Kirk, L Kent, D Cosgrove, J M Bradley, M A Tully
BACKGROUND: There are challenges for researchers and clinicians to select the most appropriate physical activity tool, and a balance between precision and feasibility is needed. Currently it is unclear which physical activity tool should be used to assess physical activity in Bronchiectasis. The aim of this research is to compare assessment methods (pedometer and IPAQ) to our criterion method (ActiGraph) for the measurement of physical activity dimensions in Bronchiectasis (BE), and to assess their feasibility and acceptability...
January 14, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28087811/twenty-years-of-social-capital-and-health-research-a-glossary
#14
S Moore, I Kawachi
Research on social capital in public health is approaching its 20th anniversary. Over this period, there have been rich and productive debates on the definition, measurement and importance of social capital for public health research and practice. As a result, the concepts and measures characterising social capital and health research have also evolved, often drawing from research in the social, political and behavioural sciences. The multidisciplinary adaptation of social capital-related concepts to study health has made it challenging for researchers to reach consensus on a common theoretical approach...
January 13, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28081482/following-lives-undergoing-change-flux-study-implementation-and-baseline-prevalence-of-drug-use-in-an-online-cohort-study-of-gay-and-bisexual-men-in-australia
#15
Mohamed A Hammoud, Fengyi Jin, Louisa Degenhardt, Toby Lea, Lisa Maher, Jeffrey Grierson, Brent Mackie, Marcus Pastorelli, Colin Batrouney, Nicky Bath, Jack Bradley, Garrett P Prestage
BACKGROUND: Drug use among gay and bisexual men (GBM) is higher than most populations. The use of crystal methamphetamine, erectile dysfunction medication (EDM), and amyl nitrite have been associated with sexual risk behaviour and HIV infection among gay and bisexual men (GBM). OBJECTIVE: This paper describes an online prospective observational study of licit and illicit drug use among GBM and explores baseline prevalence of drug use in this sample. Capturing these data poses challenges as participants are required to disclose potentially illegal behaviours in a geographically dispersed country...
January 9, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28078091/body-mass-index-measured-adiposity-and-population-attributability-of-associated-factors-a-population-based-study-from-buea-cameroon
#16
Leopold Ndemnge Aminde, Jeannine A Atem, Andre Pascal Kengne, Anastase Dzudie, J Lennert Veerman
BACKGROUND: Obesity is currently a global health challenge driven by a mix of behavioural, environmental and genetic factors. Up to date population-based disease burden estimates are needed to guide successful prevention and control efforts in African countries. We investigated the prevalence and population attributable fractions of overweight and obesity in Buea, the Southwest region of Cameroon. METHODS: Data are from a community-based cross-sectional study involving randomly selected adults conducted in 2016...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28077103/determinants-of-quality-of-shared-sanitation-facilities-in-informal-settlements-case-study-of-kisumu-kenya
#17
Sheillah Simiyu, Mark Swilling, Sandy Cairncross, Richard Rheingans
BACKGROUND: Shared facilities are not recognised as improved sanitation due to challenges of maintenance as they easily can be avenues for the spread of diseases. Thus there is need to evaluate the quality of shared facilities, especially in informal settlements, where they are commonly used. A shared facility can be equated to a common good whose management depends on the users. If users do not work collectively towards keeping the facility clean, it is likely that the quality may depreciate due to lack of maintenance...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28077072/diabetes-mellitus-medication-use-and-catastrophic-healthcare-expenditure-among-adults-aged-50-years-in-china-and-india-results-from-the-who-study-on-global-ageing-and-adult-health-sage
#18
Shingai Douglas Gwatidzo, Jennifer Stewart Williams
BACKGROUND: Expenditure on medications for highly prevalent chronic conditions such as diabetes mellitus (DM) can result in financial impoverishment. People in developing countries and in low socioeconomic status groups are particularly vulnerable. China and India currently hold the world's two largest DM populations. Both countries are ageing and undergoing rapid economic development, urbanisation and social change. This paper assesses the determinants of DM medication use and catastrophic expenditure on medications in older adults with DM in China and India...
January 11, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28074724/-tasty-food-for-cancer-patients-the-impact-of-smell-and-taste-alterations-on-eating-behaviour
#19
E M Postma, Y C de Vries, S Boesveldt
- This article provides an overview of smell and taste changes in cancer patients and the influence of these changes on eating behaviour and food preferences.- Taste changes seem to be more common than alterations in the sense of smell.- The changes in taste and smell are often temporary; smell and taste functions mostly return to their previous level after treatment cessation.- The type of cancer and its treatment influence changes in the sense of smell and taste, making it challenging to give general advice...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28072840/locomotor-activity-and-body-temperature-patterns-over-a-temperature-gradient-in-the-highveld-mole-rat-cryptomys-hottentotus-pretoriae
#20
Meghan Haupt, Nigel C Bennett, Maria K Oosthuizen
African mole-rats are strictly subterranean mammals that live in extensive burrow systems. High humidity levels in the burrows prevent mole-rats from thermoregulating using evaporative cooling. However, the relatively stable environment of the burrows promotes moderate temperatures and small daily temperature fluctuations. Mole-rats therefore display a relatively wide range of thermoregulation abilities. Some species cannot maintain their body temperatures at a constant level, whereas others employ behavioural thermoregulation...
2017: PloS One
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