Hong-Bao Li, Meng-Lu Xu, Wen-Jie Xia, Yuan-Yuan Dong, Bo Peng, Qing Su, Xiao-Min Wang, Jia-Yue Yu, Ya-Nan Gao, Jun-Zhe Wu, Meng-Yue Xu, Jin-Bao Yang, Zhi-Ming Dai, Lei Chen, Ying Li, Juan Bai
The pathogenesis of attention-deficit/hyperactivity disorder (ADHD) has not been fully elucidated. Gestational hypertension could double the probability of ADHD in the offspring, while the initial bacterial communication between the mother and offspring has been associated with psychiatric disorders. Thus, we hypothesize that antihypertensive treatment during pregnancy may abate the impairments in neurodevelopment of the offspring. To test this hypothesis, we chose Captopril and Labetalol, to apply to pregnant spontaneously hypertensive rat (SHR) dams and examined the outcomes in the male offspring...
April 26, 2024: Toxicology and Applied Pharmacology