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https://www.readbyqxmd.com/read/28547136/curiosities-of-x-chromosomal-markers-and-haplotypes
#1
Daniel Kling
Recent progress in forensic genetics has introduced a number of closely located short tandem repeat (STR) markers on the X chromosome. Inevitably, dependencies arise that have to be accounted for. This paper will in detail explore the complex statistical interpretation of X-chromosomal STR markers, focusing on likelihood calculations. Specifically, we will investigate how the phase uncertainty of haplotypes comes into play in the statistical evaluations and what curious effects this phenomenon can have. The starting point is the different real cases where the weight of evidence has provided unexpected results that require further investigation in order to be fully understood...
May 26, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28545927/stem-cells-to-restore-insulin-production-and-cure-diabetes
#2
V Sordi, S Pellegrini, M Krampera, P Marchetti, A Pessina, G Ciardelli, G Fadini, C Pintus, G Pantè, L Piemonti
BACKGROUND: The advancement of knowledge in the field of regenerative medicine is increasing the therapeutic expectations of patients and clinicians on cell therapy approaches. Within these, stem cell therapies are often evoked as a possible therapeutic option for diabetes, already ongoing or possible in the near future. AIM: The purpose of this document is to make a point of the situation on existing knowledge and therapies with stem cells to treat patients with diabetes by focusing on some of the aspects that most frequently raise curiosity and discussion in clinical practice and in the interaction with the patient...
February 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28545519/staff-s-normative-attitudes-towards-coercion-the-role-of-moral-doubt-and-professional-context-a-cross-sectional-survey-study
#3
Bert Molewijk, Almar Kok, Tonje Husum, Reidar Pedersen, Olaf Aasland
BACKGROUND: The use of coercion is morally problematic and requires an ongoing critical reflection. We wondered if not knowing or being uncertain whether coercion is morally right or justified (i.e. experiencing moral doubt) is related to professionals' normative attitudes regarding the use of coercion. METHODS: This paper describes an explorative statistical analysis based on a cross-sectional survey across seven wards in three Norwegian mental health care institutions...
May 25, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28543420/from-the-foundation-up
#4
Daniel Callahan
In 2019, The Hastings Center will celebrate its fiftieth anniversary. It is more than a bit staggering to think how far we have come since 1969. When I floated the idea of a center on bioethics to my friend and neighbor, psychiatrist Willard Gaylin, at a Christmas party in 1968-even before the word "bioethics" was used-I had only the fuzziest idea of where that would take us. Neither Will nor I had run anything, nor did we know how to raise money to support an organization. We would and did learn how, but much of what we did in those early years was made up on the fly...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28541330/museums-the-life-and-times-of-a-curiosity-monger
#5
Henry Nicholls
No abstract text is available yet for this article.
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28536284/preprinting-microbiology
#6
Patrick D Schloss
The field of microbiology has experienced significant growth due to transformative advances in technology and the influx of scientists driven by a curiosity to understand how microbes sustain myriad biochemical processes that maintain Earth. With this explosion in scientific output, a significant bottleneck has been the ability to rapidly disseminate new knowledge to peers and the public. Preprints have emerged as a tool that a growing number of microbiologists are using to overcome this bottleneck. Posting preprints can help to transparently recruit a more diverse pool of reviewers prior to submitting to a journal for formal peer review...
May 23, 2017: MBio
https://www.readbyqxmd.com/read/28535708/perceived-determinants-to-alcohol-consumption-and-misuse-a-survey-of-university-students
#7
Nicholas Muli, Briege M Lagan
AIM: Before an attempt is made to develop any population-specific behavioural change programme, it is important to know what the factors that influence behaviours are. The aim of this study was to identify what are the perceived determinants that attribute to young people's choices to both consume and misuse alcohol. METHOD: Using a descriptive survey design, a web-based questionnaire based on the Theory of Triadic Influence was administered to students aged 18-29 years at one university in Northern Ireland...
May 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/28508957/genetic-and-environmental-correlations-between-subjective-wellbeing-and-experience-of-life-events-in-adolescence
#8
Robyn E Wootton, Oliver S P Davis, Abigail L Mottershaw, R Adele H Wang, Claire M A Haworth
Some life events appear heritable due to the genetic influence on related behaviours. Shared genetic influence between negative behaviours and negative life events has previously been established. This study investigated whether subjective wellbeing and positive life events were genetically associated. Participants in the Twins Early Development Study (aged 16.32 ± .68 years) completed subjective wellbeing and life events assessments via two separate studies (overlapping N for wellbeing and life events measures ranged from 3527 to 9350)...
May 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28498333/hypervalent-iodine-reagents-in-high-valent-transition-metal-chemistry
#9
REVIEW
Felipe Cesar Sousa E Silva, Anthony F Tierno, Sarah E Wengryniuk
Over the last 20 years, high valent metal complexes have evolved from mere curiosities to being at the forefront of modern catalytic method development. This approach has enabled transformations complimentary to those possible via traditional manifolds, most prominently carbon-heteroatom bond formation. Key to the advancement of this chemistry has been the identification of oxidants that are capable of accessing these high oxidation state complexes. The oxidant has to be both powerful enough to achieve the desired oxidation as well as provide heteroatom ligands for transfer to the metal center; these heteroatoms are often subsequently transferred to the substrate via reductive elimination...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28493263/pattern-of-addiction-and-its-relapse-among-habitual-drug-abusers-in-lahore-pakistan
#10
Sadia Batool, Iram Manzoor, Shamaila Hassnain, Aslam Bajwa, Muslim Abbas, Maha Mahmood, Hina Sohail
This study assessed the pattern of drug abuse and the reasons for relapse of addiction among male drug addicts seeking rehabilitative services in different centres in Lahore, Pakistan. A cross-sectional survey was conducted on male drug abusers from April to December 2016. Nonprobability purposive sampling was done to collect a sample of 119 participants. A structured questionnaire and in-depth interviews were used for data collection. Out of 119 participants, 71.4% were in the age group 15-35 years. Educational levels were low in the majority, with 68...
May 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28488919/nuanced-aesthetic-emotions-emotion-differentiation-is-related-to-knowledge-of-the-arts-and-curiosity
#11
Kirill Fayn, Paul J Silvia, Yasemin Erbas, Niko Tiliopoulos, Peter Kuppens
The ability to distinguish between emotions is considered indicative of well-being, but does emotion differentiation (ED) in an aesthetic context also reflect deeper and more knowledgeable aesthetic experiences? Here we examine whether positive and negative ED in response to artistic stimuli reflects higher fluency in an aesthetic domain. Particularly, we test whether knowledge of the arts and curiosity are associated with more fine-grained positive and negative aesthetic experiences. A sample of 214 people rated their positive and negative feelings in response to various artworks including positive and negative themes...
May 10, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28488079/fathers-orientation-to-their-children-s-autism-diagnosis-a-grounded-theory-study
#12
Michael D Hannon, LaChan V Hannon
Sixteen fathers of individuals with autism were interviewed to develop a grounded theory explaining how they learned about their children's autism diagnosis. Results suggest the orientation process entails at least two phases: orienting oneself and orienting others. The orienting oneself phase entailed fathers having suspicion of developmental differences, engaging in research and education activities, having their children formally evaluated; inquiring about their children's prognosis, and having curiosities about autism's etiology...
May 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28486706/association-of-anhedonia-with-adolescent-smoking-susceptibility-and-initiation
#13
Matthew D Stone, Janet Audrain-McGovern, Adam M Leventhal
Introduction: Emerging literature implicates anhedonia-diminished capacity to experience pleasure-as a maintaining factor underlying cigarette smoking in adults. The role of anhedonia in adolescent smoking uptake has largely been uninvestigated, leaving unclear whether anhedonia is associated with smoking initiation and with psychosocial determinants of susceptibility to smoking initiation that could be targeted in prevention. This study examined the association of anhedonia with smoking initiation (ever smoke: yes/no) and factors indicative of susceptibility to smoking initiation among never-smokers (smoking outcome expectancies, curiosity about smoking, and willingness and future intention to initiate smoking)...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28483170/-did-mozart-suffer-from-gilles-de-la-tourette-syndrome
#14
Leonardo Palacios-Sánchez, Juan Sebastián Botero-Meneses, Laura Daniela Vergara-Méndez, Natalia Pachón, Arianna Martínez, Santiago Ramírez
The personal and private lives of great men and women in history, like writers, painters and musicians, have been the subject of great interest for many years. A clear example of this is the vast scrutiny is cast over the famous composer, Wolfgang Amadeus Mozart. What may have started as curiosity, rapidly evolved into extensive research, as the answers about the musician's legendary talent may lie in the details of his life (his childhood, his relationships, his quirks and his mannerisms). It is usually up to historians, anthropologists or philosophers to delve into the pages of old books, trying to grasp answers and clues...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28475478/curiosity-about-a-positive-or-negative-event-prolongs-the-duration-of-emotional-experience
#15
Michihiro Kaneko, Yuka Ozaki, Kazuya Horike
Some researchers claim that uncertainty prolongs the duration of emotional experiences because uncertainty toward an emotion-eliciting event prolongs attention to that event. However, some results contradict this claim. We assumed that curiosity rather than uncertainty prolongs the duration of emotional experience via attention, and that attention and emotional experience are prolonged only when uncertainty elicits curiosity. This assumption is based on the information gap theory, which proposes that curiosity increases with uncertainty, but that curiosity decreases at a certain level of uncertainty...
May 5, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28472162/the-parental-reflective-functioning-questionnaire-development-and-preliminary-validation
#16
Patrick Luyten, Linda C Mayes, Liesbet Nijssens, Peter Fonagy
This paper reports on three studies on the development and validation of the Parental Reflective Functioning Questionnaire (PRFQ), a brief, multidimensional self-report measure that assesses parental reflective functioning or mentalizing, that is, the capacity to treat the infant as a psychological agent. Study 1 investigated the factor structure, reliability, and relationships of the PRFQ with demographic features, symptomatic distress, attachment dimensions, and emotional availability in a socially diverse sample of 299 mothers of a child aged 0-3...
2017: PloS One
https://www.readbyqxmd.com/read/28471673/identifying-the-hydrogenated-planar-tetracoordinate-carbon-a-combined-experimental-and-theoretical-study-of-cal4h-and-cal4h
#17
Jing Xu, Xinxing Zhang, Shuang Yu, Yi-Hong Ding, Kit H Bowen
The chemical curiosity "planar tetracoordinate carbon" (ptC) has greatly broadened one's knowledge of molecular bonding motifs apart from the traditional, tetrahedral, van't Hoff and LeBel's concept. Synthesized ptC examples have been reported either in the solid state or in the gas phase, where the ptC core is usually metalized or organometallized. Surprisingly, there has been no experimental report on hydrogenated ptC to date. A possible answer to this situation could be the "promiscuity" of hydrogen when binding to other elements, which frustrates the formation of stable ptC that is in competition with other structures...
May 8, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28467704/cubane-arrives-on-the-cucurbituril-scene
#18
Kristýna Jelínková, Heda Surmová, Alena Matelová, Michal Rouchal, Zdeňka Prucková, Lenka Dastychová, Marek Nečas, Robert Vícha
Cubane, an intriguing chemical curiosity first studied in the early 1960s, has become a valuable structural motif and has recently been involved in the structures of a great number of prospective compounds. The first dicationic supramolecular guest 5 is prepared and derived from a 1,4-disubstituted cubane moiety, and its binding behavior toward cucurbit[n]urils (CBn) and cyclodextrins (CD) is studied. The bisimidazolium salt 5 forms 1:1 inclusion complexes with CB7, CB8, and β-CD with the respective association constants (6...
May 3, 2017: Organic Letters
https://www.readbyqxmd.com/read/28467027/cyclic-polymers-from-scientific-curiosity-to-advanced-materials-for-gene-delivery-and-surface-modification
#19
Bart Verbraeken, Richard Hoogenboom
Cyclic versus linear: The superiority of cyclic polymers over their linear counterparts is highlighted. Cyclic poly(2-oxazoline)s have been shown to provide excellent shielding properties when grafted to TiO2 surfaces and Fe3 O4 nanoparticles owing to their ultrahigh grafting densities leading to low friction surfaces, superior antifouling properties, and extreme nanoparticle stabilization.
May 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28452114/critical-thinking-curiosity-and-parsimony-in-emergency-medicine-doing-nothing-as-a-quality-measure
#20
Gerben Keijzers
Current medical decision-making is influenced by many factors, such as competing interests, distractions, as well as fear of missing an important diagnosis. This can result in ordering tests or providing treatments that can be harmful. Unnecessary tests are more likely to lead to false positive diagnosis or incidental findings that are of uncertain clinical relevance. Estimates indicate that almost one-third of all health spending is wasteful. The 'Choosing Wisely' campaign has identified many of these wasteful tests and treatments...
June 2017: Emergency Medicine Australasia: EMA
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