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https://www.readbyqxmd.com/read/28214996/alcohol-induced-retrograde-facilitation-renders-witnesses-of-crime-less-suggestible-to-misinformation
#1
Julie Gawrylowicz, Anne M Ridley, Ian P Albery, Edit Barnoth, Jack Young
RATIONALE: Research has shown that alcohol can have both detrimental and facilitating effects on memory: intoxication can lead to poor memory for information encoded after alcohol consumption (anterograde amnesia) and may improve memory for information encoded before consumption (retrograde facilitation). This study examined whether alcohol consumed after witnessing a crime can render individuals less vulnerable to misleading post-event information (misinformation). METHOD: Participants watched a simulated crime video...
February 19, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28214838/the-role-of-hippocampal-structural-synaptic-plasticity-in-repetitive-transcranial-magnetic-stimulation-to-improve-cognitive-function-in-male-samp8-mice
#2
Jiang Ma, Jinhua Wang, Chaonan Lv, Jingjuan Pang, Bing Han, Mingwei Wang, Yuan Gen
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function, but the stimulation protocols are variable and the underlying mechanism is unclear. Therefore, we intend to examine whether 5Hz rTMS with 30% maximum output could improve cognitive functions in senescence-accelerated-prone mouse 8 (SAMP8) through changing synaptic plasticity. METHODS: SAMP8 and senescence-accelerated-prone mouse/resistant 1 (SAMR1) (7-month old male) were randomly divided into 3 groups: SMAP8 rTMS group (P8-rTMS), SMAP8 sham-rTMS group (P8-sham), and SAMR1 sham-rTMS group (R1-sham)...
January 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214576/amplified-induced-neural-oscillatory-activity-predicts-musicians-benefits-in-categorical-speech-perception
#3
Gavin M Bidelman
Event-related brain potentials (ERPs) reveal musical experience refines neural encoding and confers stronger categorical perception (CP) and neural organization for speech sounds. In addition to evoked brain activity, the human EEG can be decomposed into induced (non-phase-locked) response whose various frequency bands reflect different mechanisms of perceptual-cognitive processing. Here, we aimed to clarify which spectral properties of these neural oscillations are most prone to music-related neuroplasticity and which are linked to behavioral benefits in the categorization of speech...
February 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28214573/digital-mapping-of-the-urinary-bladder-potential-for-standardized-cystoscopy-reports
#4
M C Kriegmair, T Bergen, M Ritter, P Mandel, M S Michel, T Wittenberg, C Bolenz
OBJECTIVE: To develop a standardized digital reporting tool for cystoscopy of the urinary bladder using panoramic imaging. MATERIALS & METHODS: An image processing and stitching software (Endorama(®)) was developed to generate panoramic images from cystoscopy data. In a processing phase, algorithms were modulated and refined by reference to cystoscopy sequences (n=30). Subsequently, standard systematic cystoscopies (n=12) were recorded in patients undergoing transurethral resection of a bladder tumor in order to create panoramic images...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28213730/impact-of-baseline-visceral-fat-accumulation-on-prognosis-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-systemic-therapy
#5
Ryuichi Mizuno, Akira Miyajima, Taizo Hibi, Aya Masuda, Toshiaki Shinojima, Eiji Kikuchi, Masahiro Jinzaki, Mototsugu Oya
The aim of this study was to evaluate the clinical significance of visceral fat accumulation as a prognostic factor in patients with metastatic renal cell carcinoma (mRCC) treated with systemic therapies. A total of 114 patients were retrospectively reviewed. All patients received systemic therapy for mRCC at Keio University hospital in Japan. The intra-abdominal visceral fat area was determined by computed tomography at the umbilical level. The visceral fat accumulation was defined as ≥100 cm(2). The mean visceral fat area was 107...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28213645/transcranial-direct-current-stimulation-modulates-neuronal-networks-in-attention-deficit-hyperactivity-disorder
#6
Anna Sotnikova, Cornelia Soff, Enzo Tagliazucchi, Katja Becker, Michael Siniatchkin
Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has been repeatedly shown to improve working memory (WM). Since patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in WM, the modulation of prefrontal activity with tDCS in ADHD patients may increase their WM performance as well as improve the activation and connectivity of the WM network. In the present study, this hypothesis was tested using a double-blind sham-controlled experimental design...
February 17, 2017: Brain Topography
https://www.readbyqxmd.com/read/28213398/foxo-integration-of-insulin-signaling-with-glucose-and-lipid-metabolism
#7
Sojin Lee, Henry H Dong
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the amino DNA binding domain, known as "forkhead box" domain. They mediate the inhibitory action of insulin or insulin-like growth factor on key functions involved in cell metabolism, growth, differentiation, oxidative stress, senescence, autophagy and aging. Genetic mutations in FoxO genes or abnormal expression of FoxO proteins are associated with metabolic disease, cancer or altered lifespan in humans and animals...
February 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28213162/the-effect-of-lamotrigine-on-learning-in-mice-using-the-passive-avoidance-model
#8
Fatemeh Izadpanah, Fatemeh Arab, Amin Zarghami, Ali Bijani, Sohrab Kazemi, Ali Akbar Moghadamnia
INTRODUCTION: Lamotrigine (LTG) is an antiepileptic drug that inhibits the release of glutamate by blocking sodium channels. The present study was conducted to evaluate the effect of LTG in different stages of memory using a passive avoidance learning task in mice. METHODS: Male albino mice in the weight range 20-25g were used. They were divided into four groups (control group and three groups receiving various doses of LTG). LTG was given in three doses of 10, 25, and 50mg/kg as intraperitoneal (IP) injections...
February 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28213063/impaired-spatial-performance-in-cerebellar-deficient-lurcher-mice-is-not-associated-with-their-abnormal-stress-response
#9
Jan Tuma, Yaroslav Kolinko, Dana Jelinkova, Pascal Hilber, Jan Cendelin
Both humans and laboratory animals suffering from cerebellar lesions exhibit cognitive as well as many emotional and behavioral abnormalities. These latter have been already observed in the cerebellar mutant mice currently used to highlight some aspect of autism spectrum disorders. The aim of this study was to investigate the influence of cerebellar-related stress response abnormalities on spatial learning and memory. Cerebellar-deficient Lurcher mutant mice were exposed to water environment without active escape possibility and then tested for spatial learning in the Morris water maze...
February 14, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28212939/cannabis-exacerbates-depressive-symptoms-in-rat-model-induced-by-reserpine
#10
Yasser A Khadrawy, Hussein G Sawie, Omar M E Abdel-Salam, Eman N Hosny
Cannabis sativa is one of the most widely recreational drugs and its use is more prevalent among depressed patients. Some studies reported that Cannabis has antidepressant effects while others showed increased depressive symptoms in Cannabis users. Therefore, the present study aims to investigate the effect of Cannabis extract on the depressive-like rats. Twenty four rats were divided into: control, rat model of depression induced by reserpine and depressive-like rats treated with Cannabis sativa extract (10mg/kg expressed as Δ9-tetrahydrocannabinol)...
February 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28211988/intrathecal-enzyme-replacement-therapy-reverses-cognitive-decline-in-mucopolysaccharidosis-type-i
#11
Igor Nestrasil, Elsa Shapiro, Alena Svatkova, Patricia Dickson, Agnes Chen, Amy Wakumoto, Alia Ahmed, Edward Stehel, Sarah McNeil, Curtis Gravance, Elizabeth Maher
Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disease that seriously affects the brain. Severity of neurocognitive symptoms in attenuated MPS subtype (MPS IA) broadly varies partially, due to restricted permeability of blood-brain barrier (BBB) which limits treatment effects of intravenously applied α-L-iduronidase (rhIDU) enzyme. Intrathecal (IT) rhIDU application as a possible solution to circumvent BBB improved brain outcomes in canine models; therefore, our study quantifies effects of IT rhIDU on brain structure and function in an MPS IA patient with previous progressive cognitive decline...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28211828/self-efficacy-and-quality-of-life-after-low-intensity-neuropsychological-rehabilitation-a-pre-post-intervention-study
#12
Ingrid Brands, Maud Custers, Caroline van Heugten
BACKGROUND: Being highly self-efficacious is a key factor in successful chronic disease self-management. It is unknown whether neuropsychological rehabilitation improves self-efficacy in managing the consequences of brain injury. OBJECTIVE: To investigate whether levels of general and brain injury specific self-efficacy and quality of life (QoL) increased after neuropsychological rehabilitation and whether cognitive performance was associated with self-efficacy...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211070/use-of-proximal-operator-graph-solver-for-radiation-therapy-inverse-treatment-planning
#13
Xinmin Liu, Charles Pelizzari, Andrew H Belcher, Zachary Grelewicz, Rodney D Wiersma
PURPOSE: Most radiation therapy optimization problems can be formulated as an unconstrained problem and solved efficiently by quasi-Newton methods such as the Limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) algorithm. However, several next generation planning techniques such as total variation regularization based optimization and MV+kV optimization, involve constrained or mixed-norm optimization, and cannot be solved by quasi-Newton methods. Using standard optimization algorithms on such problems often leads to prohibitively long optimization times and large memory requirements...
February 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28211002/factors-that-influence-effective-perioperative-temperature-management-by-anesthesiologists-a-qualitative-study-using-the-theoretical-domains-framework
#14
Sylvain Boet, Andrea M Patey, Justine S Baron, Karim Mohamed, Ashlee-Ann E Pigford, Gregory L Bryson, Jamie C Brehaut, Jeremy M Grimshaw
PURPOSE: Inadvertent perioperative hypothermia (IPH) is associated with a range of adverse outcomes. Safe and effective warming techniques exist to prevent IPH; however, IPH remains common. This study aimed to identify factors that anesthesiologists perceive may influence temperature management during the perioperative period. METHODS: After Research Ethics Board approval, semi-structured interviews were conducted with staff anesthesiologists at a Canadian academic hospital...
February 16, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28210957/forced-treadmill-exercise-prevents-spatial-memory-deficits-in-aged-rats-probably-through-the-activation-of-na-k-atpase-in-the-hippocampus
#15
Cláudia Vanzella, Eduardo Farias Sanches, Felipe Kawa Odorcyk, Fabrício Nicola, Janaína Kolling, Aline Longoni, Tiago Marcon Dos Santos, Angela Terezinha de Souza Wyse, Carlos Alexandre Netto
Regular physical activity has shown to improve the quality of life and to prevent age-related memory deficits. Memory processing requires proper regulation of several enzymes such as sodium-potassium adenosine triphosphatase (Na(+), K(+)-ATPase) and acetylcholinesterase (AChE), which have a pivotal role in neuronal transmission. The present study investigated the effects of a treadmill running protocol in young (3 months), mature (6 months) and aged (22 months) Wistar rats, on: (a) cognitive function, as assessed in the Water maze spatial tasks; (b) Na(+), K(+)-ATPase and AChE activities in the hippocampus following cognitive training alone or treadmill running combined with cognitive training...
February 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28210219/mice-lacking-m1-and-m3-muscarinic-acetylcholine-receptors-have-impaired-odor-discrimination-and-learning
#16
Wilson Chan, Sanmeet Singh, Taj Keshav, Ramita Dewan, Christian Eberly, Robert Maurer, Alexia Nunez-Parra, Ricardo C Araneda
The cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating the excitability of OB neurons, in particular the M1 receptor. Here, we examined the contribution of M1 and M3 mAChR subtypes to olfactory processing using mice with a genetic deletion of these receptors, the M1(-/-) and the M1/M3(-/-) knockout (KO) mice. Genetic ablation of the M1 and M3 mAChRs resulted in a significant deficit in odor discrimination of closely related molecules, including stereoisomers...
2017: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/28210217/transcranial-direct-current-stimulation-over-the-dorsolateral-prefrontal-cortex-in-schizophrenia-a-quantitative-review-of-cognitive-outcomes
#17
REVIEW
Joshua E Mervis, Riley J Capizzi, Elias Boroda, Angus W MacDonald
Cognitive deficits are a core and disabling feature of psychotic disorders, specifically schizophrenia. Current treatments for impaired cognition in schizophrenia remain insufficient. Recent research suggests transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex can potentiate cognitive improvements in healthy individuals and those with psychiatric conditions, such as schizophrenia. However, this burgeoning literature has not been quantitatively evaluated. Through a literature search and quantitative review, we identified 194 papers on tDCS, psychosis, and cognition...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28209634/cognitive-decline-in-prostate-cancer-patients-undergoing-adt
#18
Niamh Liana Mundell, Robin M Daly, Helen Macpherson, Steve F Fraser
Androgen deprivation therapy (ADT) is an effective and widely prescribed treatment for prostate cancer (PCa), but it is associated with multiple treatment induced adverse effects that impact on various musculoskeletal and cardiometabolic health outcomes. Emerging research has shown that ADT is also associated with cognitive impairment, which has been linked to a loss of independence, increased falls and fracture risk and greater use of medical services. The aim of this review is to outline the evidence related to the effect of ADT use on cognitive function, and propose a role for exercise training as part of usual care to prevent and/or manage cognitive impairments for PCa survivors on ADT...
February 16, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28209536/maternal-administration-of-melatonin-prevents-spatial-learning-and-memory-deficits-induced-by-developmental-ethanol-and-lead-co-exposure
#19
Elham Soleimani, Iran Goudarzi, Kataneh Abrari, Taghi Lashkarbolouki
Melatonin is a radical scavenger with the ability to remove reactive oxidant species. There is report that co-exposure to lead and ethanol during developmental stages induces learning and memory deficits and oxidative stress. Here, we studied the effect of melatonin, with strong antioxidant properties, on memory deficits induced by lead and ethanol co-exposure and oxidative stress in hippocampus. Pregnant rats in lead and ethanol co-exposure group received lead acetate of 0.2% in distilled drinking water and ethanol (4g/kg) by oral gavages once daily from the 5th day of gestation until weaning...
February 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28209139/stroke-caused-by-an-inflammatory-thrombus-a-case-report
#20
Kai Shan, Wei Guo
BACKGROUND: Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through increased susceptibility or direct induction. CASE PRESENTATION: A 46-year-old Chinese male initially presented with fever, headache, and impaired memory and developed disturbance of consciousness after admission. A clinical diagnosis of Staphylococcus aureus sepsis, massive cerebral infarction and haemorrhagic transformation (left internal carotid arterial system, inflammatory thrombus) were made based on brain radiography, blood culture and postoperative pathological examinations...
February 16, 2017: BMC Neurology
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