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https://www.readbyqxmd.com/read/29443782/putative-lung-adenocarcinoma-with-epidermal-growth-factor-receptor-mutation-presenting-as-carcinoma-of-unknown-primary-site-a-case-report
#1
Masahiro Yamasaki, Kunihiko Funaishi, Naomi Saito, Ayaka Sakano, Megumu Fujihara, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Nobuyuki Ohashi, Noboru Hattori
RATIONALE: Only a few cases of putative lung adenocarcinoma presenting as carcinoma of unknown primary site (CUP) with epidermal growth factor receptor (EGFR) mutation have been reported, and the efficacy of EGFR-tyrosine kinase inhibitors (TKIs) for these cases is unclear. PATIENT CONCERNS AND DIAGNOSES: A 67-year-old man complained of paresis of the right lower extremity, dysarthria, and memory disturbance. Computed tomography and magnetic resonance imaging showed multiple brain tumors with brain edema and swelling of the left supraclavicular, mediastinal, and upper abdominal lymph nodes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443650/open-oncology-notes-a-qualitative-study-of-oncology-patients-experiences-reading-their-cancer-care-notes
#2
Neha Kayastha, Kathryn I Pollak, Thomas W LeBlanc
PURPOSE: Electronic medical records increasingly allow patients access to clinician notes. Although most believe that open notes benefits patients, some suggest negative consequences. Little is known about the experiences of patients with cancer reading their medical notes; thus we aimed to describe this qualitatively. METHODS: We interviewed 20 adults with metastatic or incurable cancer receiving cancer treatment. The semistructured qualitative interviews included four segments: assessing their overall experience reading notes, discussing how notes affected their cancer care experiences, reading a real note with the interviewer, and making suggestions for improvement...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29442933/flower-shaped-mg%C3%A2-al-1-x-fe-x-co%C3%A2-layered-double-hydroxides-derived-adsorbents-with-tunable-memory-effect-for-environmental-remediation
#3
Xinrui Zhong, Zhang Zhang, Tuantuan Zhou, Peng Lu, Jin Cheng, Sining Chen, Zhifei Shu, Yichen Hong, Qiang Wang, Ahmad Umar
Herein, flower-shaped ternary layered double hydroxides (LDHs) Mg3Al1-xFex-CO3 with tunable memory effect as promising adsorbents was developed for the removal of acid red 88 anionic dye. All the samples were prepared using a co-precipitation method and were thoroughly characterized using several analytical techniques. The influence of Fe/(Al + Fe) ratio on the memory effect and dye adsorption capacity of Mg3Al1-xFex-CO3 LDHs was evaluated. Among all samples, Mg3Fe0.1Al0.9CO3 LDH resulted in the best adsorption capacity of 2709 mg/g in the first cycle...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441949/effect-of-serotonin-transporter-genotype-on-self-reported-efficacy-and-activity-changes-of-brain-prefrontal-area-in-response-to-placebo
#4
M Isawa, R Tashiro, C Naruse, Y Yamaguchi, H Itoh, T Nishimura, M Tomi, H Shimada, H Saito, M Mochizuki, E Nakashima
Patients benefit from drug therapy not only through pharmacological mechanisms, but also through non-pharmacological action (placebo effect), which may be mediated in part by the prefrontal area of the brain. We consider that the difference between responders and non-responders to placebo might be related to polymorphisms in the serotonin transporter-linked polymorphic region (5-HTTLPR). To study this idea, we performed a randomized double-blind clinical trial using caffeine and lactose (placebo). Activity in the prefrontal area of the brain was measured in terms of blood flow by means of near-infrared spectroscopy (NIRS) as an objective indicator...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29441005/atypical-within-session-motor-procedural-learning-after-traumatic-brain-injury-but-well-preserved-between-session-procedural-memory-consolidation
#5
Maria Korman, Sharon Shaklai, Keren Cisamariu, Carmit Gal, Rinatia Maaravi-Hesseg, Ishay Levy, Ofer Keren, Avi Karni, Yaron Sacher
Using the finger-to-thumb opposition sequence (FOS) learning task, we characterized motor skill learning in sub-acute patients hospitalized for rehabilitation following traumatic brain injury (TBI). Ten patients (Trained TBI) and 11 healthy participants (Trained Healthy) were trained using a multi-session protocol: a single session was afforded in the first week of the study, and four daily sessions were afforded during the second week. Intensity of practice was adapted to patients. Performance speed and accuracy were tested before and after each session...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29440996/is-there-a-canonical-cortical-circuit-for-the-cholinergic-system-anatomical-differences-across-common-model-systems
#6
REVIEW
Jennifer J Coppola, Anita A Disney
Acetylcholine (ACh) is believed to act as a neuromodulator in cortical circuits that support cognition, specifically in processes including learning, memory consolidation, vigilance, arousal and attention. The cholinergic modulation of cortical processes is studied in many model systems including rodents, cats and primates. Further, these studies are performed in cortical areas ranging from the primary visual cortex to the prefrontal cortex and using diverse methodologies. The results of these studies have been combined into singular models of function-a practice based on an implicit assumption that the various model systems are equivalent and interchangeable...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29440774/water-memory-effects-and-their-impacts-on-global-vegetation-productivity-and-resilience
#7
Laibao Liu, Yatong Zhang, Shuyao Wu, Shuangcheng Li, Dahe Qin
Memory effects refer to the impacts of antecedent climate conditions on current vegetation productivity. This temporal linkage has been found to be strong in arid and semi-arid regions. However, the dominant climatic factors that determine such patterns are still unclear. Here, we defined'water-memory effects' as the persistent effects of antecedent precipitation on the vegetation productivity for a given memory length (from 1 to up to 12 months). Based on satellite observations and climate data, we quantified the length of water-memory effects and evaluated the contributions of antecedent precipitation on current vegetation...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440390/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
#8
James G Burchfield, Melkam A Kebede, Christopher C Meoli, Jacqueline Stöckli, P Tess Whitworth, Amanda L Wright, Nolan J Hoffman, Annabel Y Minard, Xiuquan Ma, James R Krycer, Marin E Nelson, Shi-Xiong Tan, Belinda Yau, Kristen C Thomas, Natalie K Y Wee, Ee-Cheng Khor, Ronaldo F Enriquez, Bryce Vissel, Trevor J Biden, Paul A Baldock, Kyle L Hoehn, James Cantley, Gregory J Cooney, David E James, Daniel J Fazakerley
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and whether these disorders co-occur is therefore unclear. To address this question, we examined multiple physiological systems in male C57BL/6J mice following prolonged exposure to a high-fat/high-sucrose diet (HFHSD)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29439327/stabilized-low-n-amyloid-%C3%AE-oligomers-induce-robust-novel-object-recognition-deficits-associated-with-inflammatory-synaptic-and-gabaergic-dysfunction-in-the-rat
#9
William Watremez, Joshua Jackson, Bushra Almari, Samantha L McLean, Ben Grayson, Joanna C Neill, Nicolas Fischer, Ahmad Allouche, Violette Koziel, Thierry Pillot, Michael K Harte
BACKGROUND: With current treatments for Alzheimer's disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD. A new hypothesis has emerged, in which early memory loss is considered a synapse failure caused by soluble amyloid-β oligomers (Aβo). These small soluble Aβo, which precede the formation of larger fibrillar assemblies, may be the main cause of early AD pathologies...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439072/-because-my-brain-isn-t-as-active-as-it-should-be-my-eyes-don-t-always-see-a-qualitative-exploration-of-the-stress-process-for-those-living-with-posterior-cortical-atrophy
#10
Emma Harding, Mary Pat Sullivan, Rachel Woodbridge, Keir X X Yong, Anne McIntyre, Mary L Gilhooly, Kenneth J Gilhooly, Sebastian J Crutch
OBJECTIVES: To explore the stress process for individuals living with posterior cortical atrophy (PCA) and their families. DESIGN: A qualitative study using in-depth semi-structured dyadic and individual interviews with people living with a diagnosis of PCA and a family carer. Interview transcripts were thematically analysed. SETTING: Participants' homes. PARTICIPANTS: 20 individuals in the mild to moderate stages of PCA and 20 family carers...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438676/stress-induced-cellular-responses-in-immunogenic-cell-death-implications-for-cancer-immunotherapy
#11
REVIEW
Flavia Radogna, Marc Diederich
Cancer is evading the host's defense mechanisms leading to avoidance of immune destruction. During tumor progression, immune-evading cancer cells arise due to selective pressure from the hypoxic and nutrient-deprived microenvironment. Thus, therapies aiming at re-establishing immune destruction of pathological cells constitute innovating anti-cancer strategies. Accumulating evidence suggests that selected conventional chemotherapeutic drugs increase the immunogenicity of stressed and dying cancer cells by triggering a form of cell death called immunogenic cell death (ICD), which is characterized by the release of danger-associated molecular patterns (DAMPs)...
February 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29438209/an-unusual-complication-of-bone-wax-utilization
#12
Artur Fahradyan, Levonti Ohanisian, Michaela Tsuha, Matthew J Park, Jeffrey A Hammoudeh
Bone wax is a commonly used hemostatic agent with minimal complications. Some of the known complications include inflammation, granuloma formation, infection, and impaired osteogenesis. Several clinical reports of bone wax migration have also been reported. In this paper, the authors present a rare patient of bone wax migration intracranially in a 6-year-old patient who initially underwent craniotomy for the evacuation of subdural hematoma and repair of depressed skull fracture. The patient then underwent craniotomy scalp scar revision several months later...
February 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29436643/neuroprotective-effect-of-lurasidone-via-antagonist-activities-on-histamine-in-a-rat-model-of-cranial-nerve-involvement
#13
Baoming He, Liang Yu, Suping Li, Fei Xu, Lili Yang, Shuai Ma, Yi Guo
Cranial nerve involvement frequently involves neuron damage and often leads to psychiatric disorder caused by multiple inducements. Lurasidone is a novel antipsychotic agent approved for the treatment of cranial nerve involvement and a number of mental health conditions in several countries. In the present study, the neuroprotective effect of lurasidone by antagonist activities on histamine was investigated in a rat model of cranial nerve involvement. The antagonist activities of lurasidone on serotonin 5‑HT7, serotonin 5‑HT2A, serotonin 5‑HT1A and serotonin 5‑HT6 were analyzed, and the preclinical therapeutic effects of lurasidone were examined in a rat model of cranial nerve involvement...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436629/cognitive-improvement-following-ischemia-reperfusion-injury-induced-by-voluntary-running%C3%A2-wheel-exercise-is-associated-with-lncmalat1%C3%A2-mediated-apoptosis-inhibition
#14
Jin-Lin Shang, Qing Cheng, Sheng-Jie Duan, Lu Li, Li-Ya Jia
Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be associated with the functions and dysfunctions of endothelial cells. The present study investigated whether spontaneous running‑wheel (RW) exercise‑induced MALAT1 expression changes may be associated with the cognitive improvement of mice following I/R injury...
February 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29436486/randomised-double-blind-placebo-controlled-crossover-study-of-single-dose-guanfacine-in-unilateral-neglect-following-stroke
#15
Edwin S Dalmaijer, Korina M S Li, Nikos Gorgoraptis, Alexander P Leff, David L Cohen, Andrew D Parton, Masud Husain, Paresh A Malhotra
OBJECTIVE: Unilateral neglect is a poststroke disorder that impacts negatively on functional outcome and lacks established, effective treatment. This multicomponent syndrome is characterised by a directional bias of attention away from contralesional space, together with impairments in several cognitive domains, including sustained attention and spatial working memory. This study aimed to test the effects of guanfacine, a noradrenergic alpha-2A agonist, on ameliorating aspects of neglect...
February 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29436258/amnesic-patients-have-residual-prospective-memory-capacities
#16
Beat Meier, Severin Fanger, Giannina Toller, Sibylle Matter, René Müri, Klemens Gutbrod
OBJECTIVE: To investigate, in two separate studies, whether amnesic patients with a severe memory impairment can learn to perform a habitual prospective memory task when they receive immediate feedback on prospective memory failures (Study 1) and whether amnesic patients are able to benefit from previous habitual prospective memory performance after a 24-h retention interval. METHOD: A prospective memory task was embedded in a lexical decision task (Study 1) and in a perceptual discrimination task (Study 2)...
February 13, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29435917/acupuncture-prevents-the-impairment-of-hippocampal-ltp-through-%C3%AE-1-ar-in-vascular-dementia-rats
#17
Ling-Yong Xiao, Xue-Rui Wang, Jing-Wen Yang, Yang Ye, Wen Zhu, Yan Cao, Si-Ming Ma, Cun-Zhi Liu
It is widely accepted that the synaptic dysfunction and synapse loss contribute to the cognitive deficits of vascular dementia (VD) patients. We have previously reported that acupuncture improved cognitive function in rats with VD. However, the mechanisms involved in acupuncture improving cognitive ability remain to be elucidated. The present study aims to investigate the pathways and molecules involved in the neuroprotective effect of acupuncture. We assessed the effects of acupuncture on hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation...
February 13, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29435084/mitigation-of-stress-new-treatment-alternatives
#18
REVIEW
Ahmad Rauf Subhani, Nidal Kamel, Mohamad Naufal Mohamad Saad, Nanda Nandagopal, Kenneth Kang, Aamir Saeed Malik
Complaints of stress are common in modern life. Psychological stress is a major cause of lifestyle-related issues, contributing to poor quality of life. Chronic stress impedes brain function, causing impairment of many executive functions, including working memory, decision making and attentional control. The current study sought to describe newly developed stress mitigation techniques, and their influence on autonomic and endocrine functions. The literature search revealed that the most frequently studied technique for stress mitigation was biofeedback (BFB)...
February 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29434959/retrospective-observational-cohort-study-on-cosmetic-outcome-of-using-ti-ni-memory-alloy-wire-for-intradermal-suture-following-mastectomy-in-patients-with-breast-cancer
#19
Gang Li, Sida Qin, Xin Sun, Jiansheng Wang, Yunfeng Zhang, Jia Zhang, Jing Zhang, Shou-Ching Tang, Hong Ren
The method of suturing for incisions is crucial for the comprehensive treatment of clinical patients with breast cancer. Suturing is considered a major part of post-surgical recovery and may serve as a marker for evaluation of surgical outcome. The present study aimed to establish an effective means of suturing for patients who received modified radical surgery that helps to improve the cosmetic outcome of the incision. Enrolled patients were divided into an active and a control group. Ti-Ni memory alloy wire for intradermal suture in the active group and silk for interruption suture in the control group were applied to assess the different prognosis-associated factors...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434777/effects-of-donepezil-on-cognitive-functions-and-the-expression-level-of-%C3%AE-amyloid-in-peripheral-blood-of-patients-with-alzheimer-s-disease
#20
Yunxia Ma, Jinming Ji, Gang Li, Shuzhen Yang, Shuangshuang Pan
Alzheimer's disease is a degenerative disease affecting the central nervous system for which donepezil is usually prescribed. The aim of the present study was to examine the effects of donepezil on the cognitive functions and expression levels of β-amyloid (Aβ) in the peripheral blood of patients with Alzheimer's disease. In total, 76 patients with cognitive impairment, who visited the Department of Neurology of Binzhou City Center Hospital from June 2015 to September 2016, had memory decline for more than three consecutive months and underwent mini-mental state examination (MMSE) score screening, were selected for the study...
February 2018: Experimental and Therapeutic Medicine
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