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https://www.readbyqxmd.com/read/29720825/determination-of-five-chemical-markers-in-df-formula-the-herbal-composition-of-ephedra-intermedia-rheum-palmatum-and-lithospermum-erythrorhizon-using-high-performance-liquid-chromatography-ultraviolet-detection
#1
Birang Jeong, Jong Seong Roh, Michung Yoon, Yoosik Yoon, Soon Shik Shin, Hyun Joo Cho, Yong Soo Kwon, Heejung Yang
Background: DF formula is a herbal preparation comprised three medicinal herbs, namely, Ephedra intermedia , Rheum palmatum , and Lithospermum erythrorhizon , which is being used for the treatment of obesity and liver fibrosis in Korean local clinics. Objective: Since the abovementioned three herbs exist with different proportions in DF formula and their chemical markers have different physiochemical properties; it is quite challenging to develop an analytical methodology for the determination of these chemical markers...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29600603/-current-research-situation-of-nephrotoxicity-of-chinese-herbal-medicine
#2
Xue Feng, Sai-Nan Fang, Yu-Xin Gao, Jian-Ping Liu, Wei Chen
To provide the basis for the future research on the nephrotoxicity of Chinese herbal medicine through systematic and comprehensive summary of all the Chinese herbal medicines which may lead to nephrotoxicity. Foreign resources included PubMed and Cochrane library, and domestic research resources was China Food and Drug Administration(CDFA) Adverse Drug Reaction Monitoring Center database. The databases were searched from establishment to January 1, 2017. There was no limitation on research type. 28 English studies were found, including 97 Chinese herbs or prescriptions with the risk of nephrotoxicity...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29588201/promotive-effect-of-bofutsushosan-fangfengtongshengsan-on-lipid-and-cholesterol-excretion-in-feces-in-mice-treated-with-a-high-fat-diet
#3
Junji Akaki, Shiori Tachi, Naoki Nakamura, Tetsuya Arai, Hiroo Yamasaki, Makoto Inoue, Toshiaki Makino
ETHNOPHARMACOLOGICAL RELEVANCE: Bofutsushosan (fangfengtongshengsan in Chinese, BTS) is a formula in traditional Japanese Kampo medicine and Chinese medicine comprising 18 crude drugs that is used for treating obesity and metabolic syndrome. AIM OF THE STUDY: We evaluated the promotive effects of BTS on lipid and cholesterol elimination in mice. MATERIALS AND METHODS: Mice were reared with a high-fat diet containing boiled water extract of BTS for 30 days, and their biochemical parameters as well as the weight and lipid content of feces were measured...
March 24, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29552850/-effects-of-different-decocting-methods-on-quality-of-mahuang-xixin-fuzi-decoction
#4
Li-Li Qiu, Can Li, Shan-Shan Fan, Xu Han, Yong Yang, Rong Rong
To compare the quality difference between Mahuang Xixin Fuzi decoction(MXF) prepared by traditional decocting method and that prepared by two commonly used decocting methods, and explore the scientific nature of the traditional decocting method. By taking effect-toxic components in MXF as the research object, this article investigated these three different decocting methods from the quantitative determination of effect-toxic components in MXF. By using multivariate statistical analysis methods, three characteristic constituents were identified as kakoul, mesaconitine (MA) and hypaconitine (HA) respectively...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29552834/-traditional-prescription-rules-of-aconitum-herbs-in-treatment-of-bi-syndrome
#5
Xiao-Meng Zhang, Zhi-Jian Lin, Bing Zhang, Ang Li
The application of Aconitum herbs in the treatment of Bi syndrome has a long history and exact effects.By taking Aconiti Radix(Chuanwu), Aconiti Kusnezoffii Radix(Caowu) and Aconiti Lateralis Radix Preparata(Fuzi) as example, this study was aimed to mine the prescription rules of Aconitum herbs in the treatment of Bi syndrome, and provide thoughts and bases for modern clinical medication. 1 106 prescriptions were obtained in more than 20 classic books including medical, pharmacy, and synthesized books from Eastern Han dynasty to Qing dynasty...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29528886/paracentral-acute-middle-maculopathy-after-preworkout-havok-ingestion
#6
Kevin F Elwood, Robert W Wong
PURPOSE: To describe a case of transient, partial, central retinal artery occlusion with paracentral acute middle maculopathy optical coherence tomography presentation in a young healthy patient after ingestion of the synephrine-containing supplement, Havok. METHODS: Retrospective case report with fundus photography, fluorescein angiography, and optical coherence tomography. RESULTS: A 20-year-old man presented with severe acute vision loss in the right eye...
March 8, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29497901/correction-to-ephedra-herb-extract-activates-desensitizes-transient-receptor-potential-vanilloid-1-and-reduces-capsaicin-induced-pain
#7
Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Toshiko Tanaka-Kagawa, Hideto Jinno, Masashi Hyuga, Takashi Hakamatsuka, Hiroshi Odaguchi, Yukihiro Goda, Toshihiko Hanawa, Yoshinori Kobayashi
The article Ephedra Herb extract activates/desensitizes transient receptor potential vanilloid 1 and reduces capsaicin-induced pain, written by Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Toshiko Tanaka-Kagawa, Hideto Jinno, Masashi Hyuga, Takashi Hakamatsuka, Hiroshi Odaguchi, Yukihiro Goda, Toshihiko Hanawa and Yoshinori Kobayashi, was originally published Online First without open access. After publication in volume 71, issue 1, page 105-113 the author decided to opt for Open Choice and to make the article an open access publication...
March 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29407176/assessing-the-safety-of-an-ephedrae-herba-aqueous-extract-in-rats-a-repeat-dose-toxicity-study
#8
Hyoung-Yun Han, Jung-Im Huh, So-Ri Han, Myung-Gyun Kang, Seokjoo Yoon, Ji-Seok Han, Byoung-Seok Lee, Jeong Ah Kim, Byung-Sun Min
Ephedrae Herba (EH) has been used in Asian traditional herbal medicine to cure bronchial asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. In this study, we evaluated the subchronic toxicity of an Ephedrae Herba aqueous extract (EHAE) in male and female F344 rats. The EHAE was administered orally daily at doses of 0, 125, 250, 500, and 1000 mg/kg bw/day for 13 weeks. Toxicological assessment was performed to determine mortality, clinical signs, and changes in body weight, food consumption, ophthalmological, urinary, hematological, and serum biochemical parameters, macroscopic and microscopic evaluations, and organ weights...
April 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29390365/bilateral-acute-myopia-and-angle-closure-glaucoma-induced-by-ma-huang-ephedra-a-case-report
#9
So Jung Ryu, Yong Un Shin, Min Ho Kang, Hee Yoon Cho, Mincheol Seong
RATIONALE: Cases of bilateral acute angle closure have been reported after use of various drugs. PATIENT CONCERNS: A 52-year-old woman visited the emergency room and complained of acute bilateral ocular pain and decreased vision accompanied by headache, nausea, and vomiting. One day before, she had started a herbal medicine containing Ma-huang for weight loss. On examinations, myopic shift, edematous cornea, increased intraocular pressure, shallow anterior chamber, and thickened choroid on both eyes were observed...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386484/ephedrine-alkaloids-free-ephedra-herb-extract-efe-has-no-adverse-effects-such-as-excitation-insomnia-and-arrhythmias
#10
Hiroaki Takemoto, Jun Takahashi, Sumiko Hyuga, Hiroshi Odaguchi, Nahoko Uchiyama, Takuro Maruyama, Tadatoshi Yamashita, Masashi Hyuga, Naohiro Oshima, Yoshiaki Amakura, Takashi Hakamatsuka, Yukihiro Goda, Toshihiko Hanawa, Yoshinori Kobayashi
Ephedrine alkaloids-free Ephedra Herb extract (EFE) has been developed to eliminate the adverse effects caused by ephedrine alkaloid-induced sympathetic hyperactivation. Previously, we reported that EFE possesses analgesic, anti-influenza, and cancer metastatic inhibitory effects at comparable levels to that of Ephedra Herb extract (EHE). However, it has not yet been demonstrated that EFE is free from the known side effects of EHE, such as excitation, insomnia, and arrhythmias. In this study, the incidence of these adverse effects was compared between mice administered EHE and those administered EFE...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29385467/nutritional-evaluation-and-ruminal-fermentation-patterns-of-kochia-compared-with-alfalfa-and-orchardgrass-hays-and-ephedra-and-cheatgrass-compared-with-orchardgrass-hay-as-alternative-arid-land-forages-for-beef-cattle-in-two-dual-flow-continuous-culture-system
#11
Lorrayny Galoro da Silva, Claudia Batista Sampaio, Eduardo Marostegan de Paula, Teshome Shenkoru, Virginia Lucia Neves Brandao, Xiaoxia Dai, Barry Perryman, Antonio Pinheiro Faciola
The objective was to evaluate the ruminal fermentation patterns of forage kochia (FK) compared with alfalfa hay (AH) and orchardgrass hay (OH) (Exp. 1), and ephedra (EPH) and immature cheatgrass (CG) compared with OH (Exp. 2), using a dual-flow continuous culture system. Two in vitro experiments were conducted, and in each experiment, treatments were randomly assigned to six dual-flow fermenters (1,223 ± 21 mL) in a replicated 3 × 3 Latin square design, with three consecutive periods of 10 d each, consisting of 7 d for diet adaptation and 3 d for sample collection...
March 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29379155/a-genome-for-gnetophytes-and-early-evolution-of-seed-plants
#12
Tao Wan, Zhi-Ming Liu, Ling-Fei Li, Andrew R Leitch, Ilia J Leitch, Rolf Lohaus, Zhong-Jian Liu, Hai-Ping Xin, Yan-Bing Gong, Yang Liu, Wen-Cai Wang, Ling-Yun Chen, Yong Yang, Laura J Kelly, Ji Yang, Jin-Ling Huang, Zhen Li, Ping Liu, Li Zhang, Hong-Mei Liu, Hui Wang, Shu-Han Deng, Meng Liu, Ji Li, Lu Ma, Yan Liu, Yang Lei, Wei Xu, Ling-Qing Wu, Fan Liu, Qian Ma, Xin-Ran Yu, Zhi Jiang, Guo-Qiang Zhang, Shao-Hua Li, Rui-Qiang Li, Shou-Zhou Zhang, Qing-Feng Wang, Yves Van de Peer, Jin-Bo Zhang, Xiao-Ming Wang
Gnetophytes are an enigmatic gymnosperm lineage comprising three genera, Gnetum, Welwitschia and Ephedra, which are morphologically distinct from all other seed plants. Their distinctiveness has triggered much debate as to their origin, evolution and phylogenetic placement among seed plants. To increase our understanding of the evolution of gnetophytes, and their relation to other seed plants, we report here a high-quality draft genome sequence for Gnetum montanum, the first for any gnetophyte. By using a novel genome assembly strategy to deal with high levels of heterozygosity, we assembled >4 Gb of sequence encoding 27,491 protein-coding genes...
February 2018: Nature Plants
https://www.readbyqxmd.com/read/29327126/antipyretic-effect-of-herba-ephedrae-ramulus-cinnamomi-herb-pair-on-yeast-induced-pyrexia-rats-a-metabolomics-study
#13
Xiao-Ming Wang, Wen-Jie Xu, Liang-Kui Xu, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the antipyretic mechanism of Herba Ephedrae (Eph)-Ramulus Cinnamomi (RC) herb pair on yeast-induced pyrexia in rats. METHODS: Totally 30 qualifified male SD rats were randomly assigned to the normal control (NC) group, the pyrexia model (model) group, the Eph, RC and Eph-RC treatment groups by a random digital table, 6 rats in each group. Each rat received a 20% aqueous suspension of yeast (10 mL/kg) except the NC group. The 3 treatment groups were administered 8...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29321907/the-groot-effect-plant-facilitation-and-desert-shrub-regrowth-following-extensive-damage
#14
Christopher J Lortie, Eva Gruber, Alex Filazzola, Taylor Noble, Michael Westphal
Deserts are increasing in extent globally, but existing deserts are decreasing in health. The basic biology and ecology of foundation plant species in deserts are limited. This is a direct study that provides an estimate of the capacity for a locally dominant foundation shrub species in California to recover from damage. Desert shrubs are cleared and damaged by humans for many purposes including agriculture, oil and gas production, and sustainable energy developments; we need to know whether foundation species consistently facilitate the abundance and diversity of other plants in high-stress ecosystems and whether they can recover...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29231494/-optimization-of-acupoint-application-scheme-in-the-treatment-of-bronchial-asthma-based-on-the-orthogonal-design-method
#15
Kuan Shi, Wenzhong Wu, Lanying Liu, Hesheng Wang, Dong Chen, Chengyong Liu, Cong Zhang
OBJECTIVE: To study the primary and secondary factors of the allergic history, the frequency of acupoint application and the time of acupoint application in the treatment of bronchial asthma and optimize its scheme. METHODS: Eighty patients of bronchial asthma were selected as the subjects in the orthogonal trial. The herbal medicines were the empirical formula of acupoint application (prepared at the ratio as 2:2:1:1:1:1:1:1:1 of semen brassicae , rhizome corydalis , unprocessed radix kansui , asarum sieboldii , ephedra , semen lepidii , syzygium aromaticum , cortex cinnamomi and fructus gleditsiae ) and used on bilateral Feishu (BL 13), Xinshu (BL 15), Geshu (BL 17) and Shenshu (BL 23)...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29193073/carbon-and-nitrogen-stable-isotope-analyses-of-ephedra-plant-and-ephedrine-samples-and-their-application-for-methamphetamine-profiling
#16
Cuimei Liu, Peipei Liu, Wei Jia, Yingfeng Fan
In this study, stable isotope ratio analysis was used to track the precursor information of methamphetamine. The δ13 C and δ15 N values of 30 nature ephedra plants, 12 synthetic ephedrine/pseudoephedrine (ephedrine), 14 natural ephedrine, and 987 seized methamphetamine samples were measured and compared. Due to different weather and earth conditions, the δ13 C and δ15 N values of ephedra plants grown in the east and the west of Inner Mongolia showed great difference. The δ15 N values of ephedra plants were consistent with related ephedrine extracted from them...
November 28, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29172693/ephedrine-as-a-lead-compound-for-the-development-of-new-dpp-iv-inhibitors
#17
María José Ojeda-Montes, Andrea Ardid-Ruiz, Sarah Tomás-Hernández, Aleix Gimeno, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Miquel Mulero, Santiago Garcia-Vallvé, Gerard Pujadas, Cristina Valls
AIM: Extracts from Ephedra species have been reported to be effective as antidiabetics. A previous in silico study predicted that ephedrine and five ephedrine derivatives could contribute to the described antidiabetic effect of Ephedra extracts by inhibiting dipeptidyl peptidase IV (DPP-IV). Finding selective DPP-IV inhibitors is a current therapeutic strategy for Type 2 diabetes mellitus management. Therefore, the main aim of this work is to experimentally determine whether these alkaloids are DPP-IV inhibitors...
December 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29149068/a-new-uplc-ms-ms-method-for-the-characterization-and-discrimination-of-polysaccharides-from-genus-ephedra-based-on-enzymatic-digestions
#18
Yong-Gang Xia, Tian-Long Wang, Li-Ming Sun, Jun Liang, Bing-You Yang, Hai-Xue Kuang
Ephedra sinica polysaccharides have been reported to possess important activities, so quality evaluation of polysaccharides from the genus Ephedra is urgent. In this study, enzymatic digestions were performed to establish multiple saccharide fingerprints by ultra-performance liquid chromatography with electrospray ionization triple quadrupole linear ion trap mass spectrometry (UPLC-ESI-TQ-MS/MS) based on a multiple-reaction monitoring in negative mode. Under optimum UPLC-ESI⁻-TQ-MS/MS conditions, excellent separation and quantification of 21 constituents were achieved within 20 min on a solid core column with a 1...
November 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29071870/-medication-rules-of-famous-veteran-traditional-chinese-medicine-doctor-in-treatment-of-chronic-bronchitis-based-on-implicit-structure-model
#19
Li-Ping Chen, Yong-Min Cai, Jian-Sheng Li
To explore the medication rules of famous veteran traditional Chinese medicine (TCM) doctors in treatment of chronic bronchitis, a structured medical record database for famous veteran TCM doctors in modern clinical books was established. First, Lantern 3.1.2(Kongmin light) implicit structure analysis software was used to build an implicit structure model and make an implicit interpretation. Then, SAS 9.1 was adopted to mine herb-herb, herb-symptom and herb-syndrome association rules. Through the mining, 1 274 commonly used herbs for chronic bronchitis were found, including liquorice, bitter almond, pinellia, dried tangerine or orange peel, poria cocos...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28994520/-establish-quality-evaluation-system-for-standard-ephedrae-herba-decoction
#20
Jia-Yu Tong, Jung Chao, Yun-Tao Dai, Zi-Quan Fan, Dan-Dan Wang, Xue-Mei Qin, Shi-Lin Chen
To establish the quality control methods for the standard decoction of Ephedrae Herba, and provide the reference for quality evaluation method of all Chinese herbal medicine decoction.Standard decoction of Ephedrae Herba was prepared, and UPLC-UV fingerprint was established to determine the total contents of ephedrine and pseudoephedrine. Then UPLC-QTOF/MS was used to confirm the major common peaks in the fingerprint to clarify the main chemical constituents in the decoction. In addition, the stability of the process was evaluated by calculating the parameters such as the extraction ratio, transfer rate of the index components and the pH values...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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