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https://www.readbyqxmd.com/read/29327126/antipyretic-effect-of-herba-ephedrae-ramulus-cinnamomi-herb-pair-on-yeast-induced-pyrexia-rats-a-metabolomics-study
#1
Xiao-Ming Wang, Wen-Jie Xu, Liang-Kui Xu, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the antipyretic mechanism of Herba Ephedrae (Eph)-Ramulus Cinnamomi (RC) herb pair on yeast-induced pyrexia in rats. METHODS: Totally 30 qualifified male SD rats were randomly assigned to the normal control (NC) group, the pyrexia model (model) group, the Eph, RC and Eph-RC treatment groups by a random digital table, 6 rats in each group. Each rat received a 20% aqueous suspension of yeast (10 mL/kg) except the NC group. The 3 treatment groups were administered 8...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29321907/the-groot-effect-plant-facilitation-and-desert-shrub-regrowth-following-extensive-damage
#2
Christopher J Lortie, Eva Gruber, Alex Filazzola, Taylor Noble, Michael Westphal
Deserts are increasing in extent globally, but existing deserts are decreasing in health. The basic biology and ecology of foundation plant species in deserts are limited. This is a direct study that provides an estimate of the capacity for a locally dominant foundation shrub species in California to recover from damage. Desert shrubs are cleared and damaged by humans for many purposes including agriculture, oil and gas production, and sustainable energy developments; we need to know whether foundation species consistently facilitate the abundance and diversity of other plants in high-stress ecosystems and whether they can recover...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29231494/-optimization-of-acupoint-application-scheme-in-the-treatment-of-bronchial-asthma-based-on-the-orthogonal-design-method
#3
Kuan Shi, Wenzhong Wu, Lanying Liu, Hesheng Wang, Dong Chen, Chengyong Liu, Cong Zhang
OBJECTIVE: To study the primary and secondary factors of the allergic history, the frequency of acupoint application and the time of acupoint application in the treatment of bronchial asthma and optimize its scheme. METHODS: Eighty patients of bronchial asthma were selected as the subjects in the orthogonal trial. The herbal medicines were the empirical formula of acupoint application (prepared at the ratio as 2:2:1:1:1:1:1:1:1 of semen brassicae, rhizome corydalis, unprocessed radix kansui, asarum sieboldii, ephedra, semen lepidii, syzygium aromaticum, cortex cinnamomi and fructus gleditsiae) and used on bilateral Feishu (BL 13), Xinshu (BL 15), Geshu (BL 17) and Shenshu (BL 23)...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29193073/carbon-and-nitrogen-stable-isotope-analyses-of-ephedra-plant-and-ephedrine-samples-and-their-application-for-methamphetamine-profiling
#4
Cuimei Liu, Peipei Liu, Wei Jia, Yingfeng Fan
In this study, stable isotope ratio analysis was used to track the precursor information of methamphetamine. The δ13 C and δ15 N values of 30 nature ephedra plants, 12 synthetic ephedrine/pseudoephedrine (ephedrine), 14 natural ephedrine, and 987 seized methamphetamine samples were measured and compared. Due to different weather and earth conditions, the δ13 C and δ15 N values of ephedra plants grown in the east and the west of Inner Mongolia showed great difference. The δ15 N values of ephedra plants were consistent with related ephedrine extracted from them...
November 28, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29172693/ephedrine-as-a-lead-compound-for-the-development-of-new-dpp-iv-inhibitors
#5
María José Ojeda-Montes, Andrea Ardid-Ruiz, Sarah Tomás-Hernández, Aleix Gimeno, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Miquel Mulero, Santiago Garcia-Vallvé, Gerard Pujadas, Cristina Valls
AIM: Extracts from Ephedra species have been reported to be effective as antidiabetics. A previous in silico study predicted that ephedrine and five ephedrine derivatives could contribute to the described antidiabetic effect of Ephedra extracts by inhibiting dipeptidyl peptidase IV (DPP-IV). Finding selective DPP-IV inhibitors is a current therapeutic strategy for Type 2 diabetes mellitus management. Therefore, the main aim of this work is to experimentally determine whether these alkaloids are DPP-IV inhibitors...
November 27, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29149068/a-new-uplc-ms-ms-method-for-the-characterization-and-discrimination-of-polysaccharides-from-genus-ephedra-based-on-enzymatic-digestions
#6
Yong-Gang Xia, Tian-Long Wang, Li-Ming Sun, Jun Liang, Bing-You Yang, Hai-Xue Kuang
Ephedra sinica polysaccharides have been reported to possess important activities, so quality evaluation of polysaccharides from the genus Ephedra is urgent. In this study, enzymatic digestions were performed to establish multiple saccharide fingerprints by ultra-performance liquid chromatography with electrospray ionization triple quadrupole linear ion trap mass spectrometry (UPLC-ESI-TQ-MS/MS) based on a multiple-reaction monitoring in negative mode. Under optimum UPLC-ESI⁻-TQ-MS/MS conditions, excellent separation and quantification of 21 constituents were achieved within 20 min on a solid core column with a 1...
November 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29071870/-medication-rules-of-famous-veteran-traditional-chinese-medicine-doctor-in-treatment-of-chronic-bronchitis-based-on-implicit-structure-model
#7
Li-Ping Chen, Yong-Min Cai, Jian-Sheng Li
To explore the medication rules of famous veteran traditional Chinese medicine (TCM) doctors in treatment of chronic bronchitis, a structured medical record database for famous veteran TCM doctors in modern clinical books was established. First, Lantern 3.1.2(Kongmin light) implicit structure analysis software was used to build an implicit structure model and make an implicit interpretation. Then, SAS 9.1 was adopted to mine herb-herb, herb-symptom and herb-syndrome association rules. Through the mining, 1 274 commonly used herbs for chronic bronchitis were found, including liquorice, bitter almond, pinellia, dried tangerine or orange peel, poria cocos...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28994520/-establish-quality-evaluation-system-for-standard-ephedrae-herba-decoction
#8
Jia-Yu Tong, Jung Chao, Yun-Tao Dai, Zi-Quan Fan, Dan-Dan Wang, Xue-Mei Qin, Shi-Lin Chen
To establish the quality control methods for the standard decoction of Ephedrae Herba, and provide the reference for quality evaluation method of all Chinese herbal medicine decoction.Standard decoction of Ephedrae Herba was prepared, and UPLC-UV fingerprint was established to determine the total contents of ephedrine and pseudoephedrine. Then UPLC-QTOF/MS was used to confirm the major common peaks in the fingerprint to clarify the main chemical constituents in the decoction. In addition, the stability of the process was evaluated by calculating the parameters such as the extraction ratio, transfer rate of the index components and the pH values...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28981338/heart-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-4-of-5
#9
Amy C Brown
BACKGROUND: The purpose of this review was to create an online research summary table of heart toxicity case reports related to dietary supplements (DS; includes herbs). METHODS: Documented PubMed case reports of DS appearing to contribute to heart-related problems were used to create a "Toxic Table" that summarized the research (1966 to April, 2016, and cross-referencing). Keywords included "herb," "dietary supplement," and cardiac terms. Case reports were excluded if they were herb combinations (some exceptions), Chinese herb mixtures, teas of mixed herb contents, mushrooms, poisonous plants, self-harm (e...
October 5, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28966259/phylogenic-analysis-and-evaluation-of-ephedra-plants-and-aconites-for-medicinal-use
#10
Nobuko Kakiuchi
Although Kampo medicine is now fully integrated into the modern Japanese healthcare system, most Kampo formulations depend on imported crude drugs from limited foreign areas. To prepare for possible shortages of crude drugs in the future, a wider scope for the supply of medicinal plants is necessary. We conducted field research and collaborated with international laboratories for phylogenic analysis and evaluation of medicinal plant resources. Our research on ephedra plants from a wide region of Eurasia has, for example, confirmed their phylogenic structure: based on DNA sequencing analysis of nuclear ribosomal internal transcribed spacer region 1 (ITS1) as well as the chloroplast intergenic spacer between trnL and trnF (trnL-F), the 8 major Chinese species and related plants grown on the continent could be divided into 3 groups...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28947729/chemical-composition-and-antioxidant-anti-inflammatory-and-antiproliferative-activities-of-lebanese-ephedra-campylopoda-plant
#11
Hany Kallassy, Mohammad Fayyad-Kazan, Rawan Makki, Yolla El-Makhour, Hasan Rammal, David Y Leger, Vincent Sol, Hussein Fayyad-Kazan, Bertrand Liagre, Bassam Badran
No abstract text is available yet for this article.
September 26, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28933082/-transcriptome-characterization-of-ephedra-sinica-with-454-ests
#12
Hai-Xia Yan, Hong-Mei Luo, Ying Li, Yong-Zhen Sun, Chao Sun, Zhong-Zhi Qian, Shi-Lin Chen
Using the latest 454 GS FLX platform and Titanium regent, a substantial expressed sequence tag (ESTs) dataset of Ephedra sinica was produced, and the profile of gene expression and function gene of which were investigated. A total of 48 389 reads with an average length of 373 bp were generated. These 454 reads were assembled into 18 801 unigenes, which were all 454 sequencing identified. A total number of 10 531 unigenes(56.0%) were annotated using BLAST searches (E-value≤1×10⁻⁵) against the Nr, Nt, TAIR, SwissProt and KEGG databases...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28842339/gangjihwan-a-polyherbal-composition-inhibits-fat-accumulation-through-the-modulation-of-lipogenic-transcription-factors-srebp1c-ppar%C3%AE-and-c-ebp%C3%AE
#13
Jaewoong Jang, Yoonju Jung, Seyeon Chae, Soo Hyun Cho, Michung Yoon, Heejung Yang, Soon Shik Shin, Yoosik Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Gangjihwan (DF) which is composed of Ephedra intermedia, Lithospermum erythrorhizon, and Rheum palmatum has been used for the treatment of obesity in traditional medical clinics in Korea. AIM OF THE STUDY: This study was conducted to standardize DF and elucidate its mechanism of action for inhibiting fat accumulation in adipocytes and adipose tissues. MATERIALS AND METHODS: The herbal ingredients of DF were extracted in water, 30% ethanol or 70% ethanol and freeze-dried followed by HPLC analyses...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28830773/polysaccharide-from-ephedra-sinica-stapf-inhibits-inflammation-expression-by-regulating-factor-%C3%AE-1-smad2-signaling
#14
Shanshan Liang, Xianqun Meng, Zhibin Wang, Jiali Liu, Haixue Kuang, Qiuhong Wang
Mahuang, a famous traditional Chinese medicine, is widely used for the treatment of common cold and inflammatory diseases in China. We investigated the protective effects of polysaccharide from Ephedra sinica Stapf (ESP-B4) against airway and pulmonary inflammation. Animal model was made in SD rats via intratracheal instillation of Lipopolysaccharides (LPS) on day1 and 14 and inhalation of Cigarette Smoke (CS) for 4 weeks. ESP-B4 was administered by oral gavage for 2 weeks. We studied the number of inflammatory cells in serum, production of TNF-α, IL-6, IL-8 and MMP-9 in lung homogenization buffer, and the expression of TGF-β1, P-Smad2 and P-Smad3 in lung tissue...
August 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28827820/strong-dependence-of-a-pioneer-shrub-on-seed-dispersal-services-provided-by-an-endemic-endangered-lizard-in-a-mediterranean-island-ecosystem
#15
Constanza Neghme, Luís Santamaría, María Calviño-Cancela
The accelerating rate of vertebrate extinctions and population declines threatens to disrupt important ecological interactions, altering key ecosystem processes such as animal seed dispersal. The study of highly specialized mutualistic interactions is crucial to predict the consequences of population declines and extinctions. Islands offer unique opportunities to study highly specialized interactions, as they often have naturally depauperated faunas and are experiencing high rates of human-driven extinctions...
2017: PloS One
https://www.readbyqxmd.com/read/28822149/-ecology-suitability-study-of-ephedra-intermedia
#16
Xiao-Hui Ma, You-Yuan Lu, De-Dong Huang, Tian-Tian Zhu, Pei-Lin Lv, Ling Jin
The study aims at predicting ecological suitability of Ephedra intermedia in China by using maximum entropy Maxent model combined with GIS, and finding the main ecological factors affecting the distribution of E. intermedia suitability in appropriate growth area. Thirty-eight collected samples of E. intermedia and E. intermedia and 116 distribution information from CVH information using ArcGIS technology were analyzed. MaxEnt model was applied to forecast the E. intermedia in our country's ecology. E. intermedia MaxEnt ROC curve model training data and testing data sets the AUC value was 0...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28783085/characterization-of-proanthocyanidin-oligomers-of-ephedra-sinica
#17
Joanna Orejola, Yosuke Matsuo, Yoshinori Saito, Takashi Tanaka
Ephedra sinica, an important plant in Chinese traditional medicine, contains a complex mixture of proanthocyanidin oligomers as major constituents; however, only the minor components have been chemically characterized. In this study, oligomers with relatively large molecular weights, which form the main body of the proanthocyanidin fractions, were separated by adsorption and size-exclusion chromatography. Acid-catalyzed degradation in the presence of mercaptoethanol or phloroglucinol led to the isolation of 18 fragments, the structures of which were elucidated from their experimental and TDDFT-calculated ECD spectra...
August 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28776291/two-flavone-c-glycosides-as-quality-control-markers-for-the-manufacturing-process-of-ephedrine-alkaloids-free-ephedra-herb-extract-efe-as-a-crude-drug-preparation
#18
Naohiro Oshima, Takuro Maruyama, Tadatoshi Yamashita, Nahoko Uchiyama, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga, Shunsuke Nakamori, Hiroaki Takemoto, Yoshinori Kobayashi, Takashi Hakamatsuka, Hiroshi Odaguchi, Toshihiko Hanawa, Yukihiro Goda
As part of our continuing study of ephedrine alkaloids-free Ephedra Herb extract (EFE) in pursuit of its approval as a crude drug preparation, we identified two quantitative markers for the quality control of the manufacturing process of EFE and sought to establish cost-effective and simple methods for quantitative analyses. We analysed Ephedra Herb extracts grown in different habitats and collection years by liquid chromatography/high-resolution mass spectrometry (LC/HRMS) and detected two notable peaks common to each extract...
August 3, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28755953/kidney-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-3-of-5-series
#19
REVIEW
Amy Christine Brown
BACKGROUND: No tabular summary of potentially life-threatening, kidney-toxic dietary supplements (DS; includes herbs) based on PubMed case reports is currently available online and continually updated to forewarn United States consumers, clinicians, and companies manufacturing DS. The purpose of this review was to create an online research summary table of kidney toxicity case reports related to DS. METHODS: Documented PubMed case reports (1966 to May 2016, and cross-referencing) of DS appearing to contribute to kidney toxicity were listed in "DS Toxic Tables...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28755076/comparative-pharmacokinetics-of-three-phenylpropanoids-in-rat-plasma-after-oral-administration-of-ramulus-cinnamomi-and-ramulus-cinnamomi-ephedrae-herba-herb-couple-extract
#20
Ping Wei, Qing-Fa Tang, Hui-Ling Huo, Fei-Long Chen, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the pharmacokinetic characteristics of three phenylpropanoids (cinnamic acid, cinnamic alcohol and coumarin) in Ramulus Cinnamomi (GZ) and Ramulus Cinnamomi-Ephedrae Herba (MH) herb-couple (GZMH). METHODS: Twelve male Sprague-Dawley rats were randomly and equally divided into the GZ and GZMH herb-couple groups. Blood samples were collected at 0, 0.08, 0.25, 0.5, 0.75, 1.5, 3, 4, 6, 8, 12, 24, 36 and 48 h after oral administration. The three phenylpropanoids in rat plasma were quantified using an ultra-performance liquid-chromatography with tandem mass spectrometry (UPLC-MS/MS) method for pharmacokinetic study...
July 28, 2017: Chinese Journal of Integrative Medicine
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