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https://www.readbyqxmd.com/read/28717105/ephedrine-induced-mitophagy-via-oxidative-stress-in-human-hepatic-stellate-cells
#1
Ah Young Lee, Yoonjeong Jang, Seong-Ho Hong, Seung-Hee Chang, Sungjin Park, Sanghwa Kim, Kyung-Sun Kang, Ji-Eun Kim, Myung-Haing Cho
The herb Ephedra sinica (also known as Chinese ephedra or Ma Huang), used in traditional Chinese medicine, contains alkaloids identical to ephedrine and pseudoephedrine as its principal active constituents. Recent studies have reported that ephedrine has various side effects in the cardiovascular and nervous systems. In addition, herbal Ephedra, a plant containing many pharmacologically active alkaloids, principally ephedrine, has been reported to cause acute hepatitis. Many studies reported clinical cases, however, the cellular mechanism of liver toxicity by ephedrine remains unknown...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28706557/comparative-pharmacokinetics-and-bioavailability-of-three-ephedrines-in-rat-after-oral-administration-of-unprocessed-and-honey-fried-ephedra-extract-by-response-surface-experimental-design
#2
Yezhe Cheng, Yu Zhang, Hang Xing, Kun Qian, Longshan Zhao, Xiaohui Chen
Ephedra have been used as a common traditional Chinese medicine for thousands of years. However, the perspiration effect of the unprocessed ephedra was too strong. Clinical trials have shown that processing methods play a critical role in moderating the perspiration property of ephedra according to the needs. A LC-MS/MS method was developed and validated to compare the pharmacokinetic properties of the three ephedrines after oral administration of unprocessed and honey-fried ephedra extract. The contents of honey, frying temperature, and frying time were set at 20%, 116°C, and 7 min by the Box-Behnken response surface method, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28602867/effect-of-gangjihwan-on-hepatic-steatosis-and-inflammation-in-high-fat-diet-fed-mice
#3
Jong Seong Roh, Haerim Lee, Jonghoon Lim, Jeongjun Kim, Heejung Yang, Yooshik Yoon, Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Gangjihwan (DF), a polyherbal drug composed of Ephedra intermedia Schrenk et C. A. Mayer (Ephedraceae), Lithospermum erythrorhizon Siebold et Zuccarini (Borraginaceae), and Rheum palmatum L. (Polygonaceae), is used to treat obesity in local Korean clinics. The constituents of DF have traditionally been reported to exert anti-obesity and anti-nonalcoholic fatty liver disease (NAFLD) effects. Thus, we investigated the effects of DF on obesity and NAFLD and the underlying mechanisms...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28573229/analysis-of-phenolic-and-flavonoids-of-wild-ephedra-alata-plant-extracts-by-lc-pda-and-lc-ms-and-their-antioxidant-activity
#4
Fuad Al-Rimawi, Saleh Abu-Lafi, Jehad Abbadi, Ayman A A Alamarneh, Raneen A Sawahreh, Imad Odeh
BACKGROUND: Ephedra is among Palestinian medicinal plants that are traditionally used in folkloric medicine for treating many diseases. Ephedra is known to have antibacterial and antioxidant effects. The goal of this study is to evaluate the antioxidant activity of different extracts from the Ephedra alata plant growing wild in Palestine, and to analyze their phenolic and flavonoid constituents by HPLC/PDA and HPLC/MS. MATERIALS AND METHODS: Samples of the Ephedra alata plant grown wild in Palestine were extracted with three different solvents namely, 100% water, 80% ethanol, and 100% ethanol...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28545666/mahuannin-b-an-adenylate-cyclase-inhibitor-attenuates-hyperhidrosis-via-suppressing-%C3%AE-2-adrenoceptor-camp-signaling-pathway
#5
Zengyong Wang, Yu Cui, Guoyu Ding, Mengge Zhou, Xiaoyao Ma, Yuanyuan Hou, Min Jiang, Dailin Liu, Gang Bai
BACKGROUND: Based on the traditional application of traditional Chinese Medicines (TCMs), Ephedra Herba (EH) is used to cure cold fever by inducing sweating, whereas Ephedra Radix (ER) is used to treat hyperhidrosis. Although they come from the same plant, Ephedra sinica Stapf, but have play opposing roles in clinical applications. EH is known to contain ephedrine alkaloids, which is the driver of the physiological changes in sweating, heart rate and blood pressure. However, the active pharmacological ingredients (APIs) of ER and the mechanisms by which it restricts sweating remain unknown...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545248/ephedra-treated-donor-derived-gut-microbiota-transplantation-ameliorates-high-fat-diet-induced-obesity-in-rats
#6
Jing-Hua Wang, Bong-Soo Kim, Kyungsun Han, Hojun Kim
Changes in gut microbiota (GM) are closely associated with metabolic syndrome, obesity, type 2 diabetes and so on. Several medicinal herbs, including Ephedra sinica (Es), have anti-obesity effects that ameliorate metabolic disorders. Therefore, in this study we evaluated whether Es maintains its anti-obesity effect through Es-altered gut microbiota (EsM) transplantation. GM was isolated from cecal contents of Es treated and untreated rats following repeated transplants into obese rats via oral gavage over three weeks...
May 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28528483/fossil-record-of-ephedra-in-the-lower-cretaceous-aptian-argentina
#7
Gabriela G Puebla, Ari Iglesias, María A Gómez, Mercedes B Prámparo
Fossil plants from the Lower Cretaceous (upper Aptian) of the La Cantera Formation, Argentina, are described. The fossils studied represent a leafy shooting system with several orders of articulated and striated axes and attached leaves with unequivocal ephedroid affinity. We also found associated remains of ovulate cones with four whorls of sterile bracts, which contain two female reproductive units (FRU). Ovulate cone characters fit well within the genus Ephedra. Special characters in the ovulate cones including an outer seed envelope with two types of trichomes, allowed us to consider our remains as a new Ephedra species...
May 20, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28491106/in-vitro-antioxidant-and-antimicrobial-activities-of-ephedra-gerardiana-root-and-stem-crude-extract-and-fractions
#8
Aman Khan, Gul Jan, Afsar Khan, Farzana Gul Jan, Ali Bahadur, Muhammad Danish
The utilization of medicinal plants to treat infectious disease is a common practice in developing countries worldwide. The present study was aimed at evaluating the crude extracts of Ephedra gerardiana (root and stem) with different chemicals for antioxidant and antimicrobial (fungal and bacterial) potential. The results revealed that the ethyl acetate fractions of E. gerardiana (root and stem) have significant free radical scavenging potential with values 2.96 ± 0.39 and 2.73 ± 0.84 while n-butanol and aqueous fractions showed IC502...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28444836/ephedra-alkaloid-contents-of-chinese-herbal-formulae-sold-in-taiwan
#9
Chih-Wei Chang, Szu-Yun Hu, Guan-Qian Huang, Mei-Chich Hsu
Consumption of Ephedra alkaloids has been prohibited in-competition by the World Anti-Doping Agency (WADA). In Taiwan, colds are often treated with Chinese herbal formulae containing Herba Ephedrae. We screened the products sold in Taiwan and preliminarily assessed their relationships with WADA threshold violations. Fifty-six concentrated powder products, including 19 Chinese herbal formulae that contained Herba Ephedrae, were collected. The content of Ephedra alkaloids, namely ephedrine (E), methylephedrine (ME), norpseudoephedrine (NPE; cathine), pseudoephedrine (PE), and norephedrine (NE; phenylpropanolamine), was determined using a validated high-performance liquid chromatography method...
April 25, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28433637/inhibition-of-pro-inflammatory-enzymes-by-medicinal-plants-from-the-argentinean-highlands-puna
#10
Romina Torres-Carro, María Inés Isla, Samanta Thomas-Valdes, Felipe Jiménez-Aspee, Guillermo Schmeda-Hirschmann, María Rosa Alberto
ETHNOPHARMACOLOGICAL RELEVANCE: Human groups in the Argentinean Andes highlands (Puna) selected native plants as anti-inflammatory agents. The indications of use are mainly to relieve pain, in infusions, ethanolic extracts or plasters. AIM OF THE STUDY: The objective of the study was to assess the effect of hydroalcoholic extracts from native highland plants as anti-inflammatory according to the traditional indications of use. The chemical profile of the three most active species was analyzed by HPLC-ESI-MS to get in insight into the constituents and the effects observed, according to the ethnopharmacological information...
April 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28433183/corrigendum-to-comparative-tissue-distribution-and-excretion-study-of-alkaloids-from-herba-ephedrae-radix-aconiti-lateralis-extracts-in-rats-j-pharm-biomed-anal-134-2017-137-142
#11
Mengyue Ren, Shuai Song, Dedong Liang, Weiting Hou, Xiaomei Tan, Jiabo Luo
No abstract text is available yet for this article.
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28387961/chemical-profiling-combined-with-omics-technologies-cp-omics-a-strategy-to-understand-the-compatibility-mechanisms-and-simplify-herb-formulas-in-traditional-chinese-medicines
#12
Tengfei Xu, Zifeng Pi, Shu Liu, Fengrui Song, Zhiqiang Liu
INTRODUCTION: The compatibility mechanisms of formulas in traditional Chinese medicine (TCM) are indistinct. In order to better understand the compatibility mechanisms and the quality control of the formulas, it is necessary to simplify formulas in TCM research. OBJECTIVE: Developing a novel method by multi-analysing the contents of different compounds in formula and inferred simplified formula simultaneously. METHODOLOGY: Chemical profiling combined with "omics" technologies (CP-omics) was employed in the present study...
April 7, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28386582/preliminary-phytochemical-screening-quantitative-analysis-of-alkaloids-and-antioxidant-activity-of-crude-plant-extracts-from-ephedra-intermedia-indigenous-to-balochistan
#13
Rahman Gul, Syed Umer Jan, Syed Faridullah, Samiullah Sherani, Nusrat Jahan
The aim of this study was to evaluate the antioxidant activity, screening the phytogenic chemical compounds, and to assess the alkaloids present in the E. intermedia to prove its uses in Pakistani folk medicines for the treatment of asthma and bronchitis. Antioxidant activity was analyzed by using 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay. Standard methods were used for the identification of cardiac glycosides, phenolic compounds, flavonoids, anthraquinones, and alkaloids. High performance liquid chromatography (HPLC) was used for quantitative purpose of ephedrine alkaloids in E...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28337389/development-of-microsatellite-markers-using-illumina-miseq-sequencing-to-characterize-ephedra-gerardiana-ephedraceae
#14
Ji De, Weidong Zhu, Tianmeng Liu, Zhe Wang, Yang Zhong
PREMISE OF THE STUDY: Ephedragerardiana (Ephedraceae), occurring in the Himalayan ranges, is an important plant species used in Tibetan medicine. Due to the lack of molecular markers to characterize genetic diversity, knowledge for conservation and uses of E. gerardiana resources is limited; we therefore developed microsatellite markers for use in this species. METHODS AND RESULTS: Using Illumina MiSeq sequencing technology, we developed 29 polymorphic microsatellite loci suitable for E...
March 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28238155/safety-of-herbal-medicine-use-during-chemotherapy-in-patients-with-ovarian-cancer-a-bedside-to-bench-approach
#15
Eran Ben-Arye, Ofer Lavie, Noah Samuels, Hazem Khamaisie, Elad Schiff, Orit Gressel Raz, Jamal Mahajna
In this study, we explored herbal supplements used by patients during chemotherapy and test for herb-drug interactions and response of cancer cells to treatment. Patients with gynecological cancer referred to a complementary and integrative medicine (CIM) service were asked about their use of herbal medicine during chemotherapy. The leading five clinically relevant herbs selected for cytotoxicity analysis included the following: wheatgrass (Triticum aestivum), European mistletoe (Viscum album), ginger (Zingiber officinale), Ephedra (Ephedra campylopoda), and Oriental mistletoe (Viscum cruciatum)...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28209447/topical-aqueous-extract-of-ephedra-alata-can-improve-wound-healing-in-an-animal-model
#16
Naim Kittana, Hanood Abu-Rass, Ruba Sabra, Lama Manasra, Hadeel Hanany, Nidal Jaradat, Fatima Hussein, Abdel Naser Zaid
PURPOSE: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. METHODS: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E...
April 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28157413/exploring-the-new-phenomena-of-home-made-extraction-and-injection-of-ephedra-plant-product-in-georgia
#17
David Otiashvili, Irma Kirtadze, Dessa Bergen-Cico
BACKGROUND: Since the end of 2015, reports by service providers have indicated a new trend in kitchen (homemade) production of an injection drug prepared from an ephedrine-containing conifer bush that is indigenous to the region. OBJECTIVE: The aim of this report is to describe an emerging new homemade psychoactive drug synthesized from the ephedra plant, and the drug consumption methods associated with its' use in the Eurasia. METHODS: Focus groups conducted with 16 people, self-identified as injection drug users (IDU's) who reported at least one incidence of ephedra preparation injection during the previous 30-days...
February 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28154331/clinical-research-testing-the-usefulness-of-ephedrine-alkaloids-free-ephedra-herb-extract
#18
REVIEW
Hiroshi Odaguchi
 We aimed to test the clinical usefulness of ephedrine alkaloids-free Ephedra Herb extract (EFE), which has been proven to be effective and safe in animal studies. First, we performed a safety trial with 7 healthy volunteers, and increased white blood cell counts were observed in 2. However, it was unknown whether this observation was a result of EFE administration. Then, we implemented a controlled, double-blind, randomized crossover trial as the second safety trial for EFE. The trial was conducted under strict conditions, and the participants were managed in the hospital and monitored using an increased number of endpoints...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28154330/analgesic-effects-and-side-effects-of-ephedra-herb-extract-and-ephedrine-alkaloids-free-ephedra-herb-extract
#19
REVIEW
Yoshinori Kobayashi
 Ephedra Herb is classified "pungent, slightly bitter, and warm" in tastes and natures, and is used to provide warmth to the body, dispel coldness, remove dampness, and reduce pain. Similar herbs are "pungent and hot" chili peppers, "pungent and hot" evodia fruit," "pungent and warm" ginger, "pungent and hot" processed ginger, "pungent and hot" Zanthoxylum fruit, etc. These herbs are prescribed to provide heat to the outer or inner body. Some pungent components such as capsaicin, evodiamine, gingerol, and shogaol are known to be activators of transient receptor potential vanilloid 1 (TRPV1)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28154329/the-pharmacological-actions-of-ephedrine-alkaloids-free-ephreda-herb-extract-and-preparation-for-clinical-application
#20
REVIEW
Sumiko Hyuga
 Ephedra Herb is defined in the 17th edition of the Japanese Pharmacopoeia as the terrestrial stem of Ephedra sinica STAPF., Ephedra intermedia SCHRENK et C.A. MEYER, or Ephedra equisetina BUNGE (Ephedraceae) which contains more than 0.7% ephedrine alkaloids (ephedrine and pseudoephedrine). The primary effects and adverse effects of Ephedra Herb are traditionally believed to be mediated by ephedrine alkaloids. We recently reported that Ephedra Herb extract (EHE) exhibits antimetastatic and antitumor effects by suppressing the hepatocyte growth factor-c-Met signaling pathway through the inhibition of c-Met tyrosine kinase activity...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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