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https://www.readbyqxmd.com/read/28638872/hemorheology-index-changes-in-a-rat-acute-blood-stasis-model-a-systematic-review-and-meta-analysis
#1
Jun-Xiu Zhang, Yu Feng, Yin Zhang, Yi Liu, Shao-Dan Li, Ming-Hui Yang
BACKGROUND: Blood stasis has received increasing attention in research related to traditional Chinese medicine (TCM) and integrative Chinese and Western medicine. More than 90% of research studies use hemorheology indexes to evaluate the establishment of animal blood stasis models rather than pathological methods, as hemorheology index evaluations of blood stasis were short of the consolidated standard. The aim of this study was to evaluate the accuracy of hemorheology indexes in rat models of acute blood stasis (ABS) based on studies in which the ABS model had been confirmed by pathological methods...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28637781/detecting-optic-nerve-head-swelling-on-ultrasound-and-optical-coherence-tomography-in-children-and-young-people-an-observational-study
#2
Annegret Hella Dahlmann-Noor, Gillian W Adams, Moritz Claudius Daniel, Alison Davis, Joanne Hancox, Melanie Hingorani, Patricia Ibanez, Becky McPhee, Himanshu Patel, Marie Restori, Clare Roberts, Maria Theodorou, James Acheson
BACKGROUND: Following high-profile cases, referrals for evaluation of 'suspicious optic discs' to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch's membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available...
June 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28625905/the-influence-of-mri-features-on-surgical-decision-making-in-degenerative-cervical-myelopathy-results-from-a-global-survey-of-aospine-international-members
#3
Aria Nouri, Allan R Martin, Anick Nater, Christopher D Witiw, So Kato, Lindsay Tetreault, Hamed Reihani-Kermani, Carlo Santaguida, Michael G Fehlings
OBJECTIVE: We conducted a survey to understand how specific pathologic features on MRI influence surgeons toward an anterior or posterior surgical approach in Degenerative Cervical Myelopathy (DCM) . METHODS: A questionnaire was sent out to 6,179 AOSpine International members via email. This included 18 questions on a 7-point Likert scale regarding how MRI features influence the respondent's decision to perform an anterior or posterior surgical approach. Influence was classified based on the mean and mode...
June 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28623897/altered-somatosensory-profile-according-to-quantitative-sensory-testing-in-patients-with-degenerative-lumbar-spine-disorders-scheduled-for-surgery
#4
Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott, Birgitta Öberg
BACKGROUND: Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes, in patients with degenerative lumbar spine disorders pre-surgery. The aim was to describe somatosensory profiles in patients with degenerative lumbar spine disorders, to identify the proportion with altered somatosensory profile, and to analyze demographic characteristics, self-reported function, pain, and health pre- and 3 months post-surgery...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28620118/role-of-p38-mapk-pathway-in-the-effects-of-high-magnitude-compression-on-nucleus-pulposus-cell-senescence-in-a-disc-perfusion%C3%A2-culture
#5
Pei Li, Ruijie Zhang, Yuan Xu, Lei Song, Qiang Zhou
Nucleus pulposus (NP) cell senescence is a typical pathological feature within the degenerative intervertebral disc. As a potential inducing and aggregating factor of disc degeneration, mechanical overloading affects disc biology in multiple ways. This study was to investigate the NP cell senescence-associated phenotype under intermittent high compression in an ex vivo disc bioreactor culture, and the role of the p38-MAPK pathway in this regulatory process. Porcine discs were cultured in culture chambers of a self-developed mechanically active bioreactor and subjected to different magnitudes of dynamic compression (low-magnitude and high-magnitude: 0...
June 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28615013/short-term-poor-glycemic-control-and-retinal-microvascular-changes-in-pediatric-type-1-diabetes-patients-in-singapore-a-pilot-study
#6
Ling-Jun Li, Ecosse Lamoureux, Tien Yin Wong, Ngee Lek
BACKGROUND: Poor glycemic control in Type 1 Diabetes (T1D) patients is strongly associated with an increased risk of diabetes-related microvascular complications later in life, but it is unclear whether short period of poor glycemic control in children with T1D can cause evident microvascular morphological changes long before any pathological manifestation. Our study aimed to investigate the longitudinal association between poor glycemic control and subsequent changes in retinal microvasculature, in a pilot study of 55 pediatric T1D patients from Singapore after a one-year follow-up...
June 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28604460/intention-to-treat-analysis-of-radical-trachelectomy-for-early-stage-cervical-cancer-with-special-reference-to-oncologic-failures-single-institutional-experience-in-hungary
#7
Robert Póka, Szabolcs Molnár, Péter Daragó, János Lukács, Rudolf Lampé, Zoárd Krasznai, Zoltán Hernádi
OBJECTIVE: The aim of our study was to evaluate clinical and pathological data in order to draw eligibility criteria for oncologically sufficient radical trachelectomy (RT) in early-stage cervical cancer. Reviewing all cases of attempted RT performed at our unit, we focused attention on prognostic indicators of the need for additional oncologic treatment following RT. The analysis was extended by extensive literature review to include previously published cases of oncologic failures. METHODS: The authors retrospectively analyzed data of patients who underwent RT at the Department of Obstetrics and Gynecology, University of Debrecen...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28598142/arthroscopic-eminoplasty-a-new-choice-of-treatment-for-tmj-internal-derangement
#8
Blas Garcia Medina, Paolo Cariati, Pablo Galvez, Almudena Cabello Serrano, Miguel Garcia Martin
BACKGROUND: Temporomandibular joint (TMJ) internal derangement is a common disabling disorder that is often underestimated by society. The main goal of our study is to show the clinic improvement experienced by patients that underwent arthroscopic eminoplasty as a treatment for TMJ in our center. METHODS: 19 patients (1 male, 18 females) agreed to participate voluntarily in our study. These patients presented signs and symptoms of TMJ internal derangement and pathological MRI images, and underwent arthroscopic eminoplasty in our center...
June 9, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28588715/aurka-mrna-expression-is-an-independent-predictor-of-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#9
Ahmed S K Al-Khafaji, Michael W Marcus, Michael P A Davies, Janet M Risk, Richard J Shaw, John K Field, Triantafillos Liloglou
Deregulation of mitotic spindle genes has been reported to contribute to the development and progression of malignant tumours. The aim of the present study was to explore the association between the expression profiles of Aurora kinases (AURKA, AURKB and AURKC), cytoskeleton-associated protein 5 (CKAP5), discs large-associated protein 5 (DLGAP5), kinesin-like protein 11 (KIF11), microtubule nucleation factor (TPX2), monopolar spindle 1 kinase (TTK), and β-tubulins (TUBB) and (TUBB3) genes and clinicopathological characteristics in human non-small cell lung carcinoma (NSCLC)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28587986/angle-ply-biomaterial-scaffold-for-annulus-fibrosus-repair-replicates-native-tissue-mechanical-properties-restores-spinal-kinematics-and-supports-cell-viability
#10
Ryan Borem, Allison Madeline, Joshua Walters, Henry Mayo, Sanjitpal Gill, Jeremy Mercuri
Annulus fibrosus (AF) damage commonly occurs due to intervertebral disc (IVD) degeneration/herniation. The dynamic mechanical role of the AF is essential for proper IVD function and thus it is imperative that biomaterials developed to repair the AF withstand the mechanical rigors of the native tissue. Furthermore, these biomaterials must resist accelerated degradation within the proteolytic environment of degenerate IVDs while supporting integration with host tissue. We have previously reported a novel approach for developing collagen-based, multi-laminate AF repair patches (AFRPs) that mimic the angle-ply architecture and basic tensile properties of the human AF...
June 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28586059/identification-of-critical-genes-in-nucleus-pulposus-cells-isolated-from-degenerated-intervertebral-discs-using-bioinformatics-analysis
#11
Zhuangchen Zhu, Guang Chen, Wei Jiao, Defeng Wang, Yan Cao, Qingfu Zhang, Junqin Wang
Intervertebral disc (IVD) degeneration is a pathological process, which may lead to lower back pain. The present study aimed to investigate the pathogenesis of IVD degeneration. GSE42611 was downloaded from Gene Expression Omnibus, including 4 nucleus pulposus samples isolated from degenerated IVDs and 4 nucleus pulposus samples separated from normal IVDs. The differentially expressed genes (DEGs) between the degenerated and normal samples were screened using the limma package in R. Functional and pathway enrichment analyses were conducted separately for the upregulated and downregulated genes, using Database for Annotation, Visualization and Integrated Discovery software...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28583914/association-between-col11a1-rs1337185-and-adamts5-rs162509-gene-polymorphisms-and-lumbar-spine-pathologies-in-chinese-han-population-an-observational-study
#12
Hua Jiang, Qinghua Yang, Jie Jiang, Xinli Zhan, Zengming Xiao
OBJECTIVES: A previous study identified a significant association between several single nucleotide polymorphisms (SNPs) and lumbar disc degeneration (LDD) in Indians. To validate the association between these SNPs and specific lumbar spine pathologies, we performed a case-control study in Chinese Han population. DESIGN: An observational study. SETTING: University Hospital in Nanning, China. PARTICIPANTS: This study included 428 patients with LDD and 400 normal controls...
June 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28579788/primary-angle-closure-glaucomas-disturb-regional-spontaneous-brain-activity-in-the-visual-pathway-an-fmri-study
#13
Wei Chen, Li Zhang, Yong-Gen Xu, Kai Zhu, Man Luo
OBJECTIVE: To explore the underlying regional brain activity deficits in the visual cortex in patients with primary angle-closure glaucoma (PACG) relative to normal controls (NCs) using regional homogeneity (ReHo) method, and its relationship with behavioral performances. PATIENTS: Twenty PACG patients (10 females, 10 males; mean age ± standard deviation [SD]: 54.42±9.46 years) and 20 age-, and sex status-matched NCs (10 females, 10 males; mean age ± SD: 53.75±9...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28573222/the-biological-activities-of-moltkia-aurea-boiss-an-endemic-species-to-turkey
#14
Neslihan Balpinar, Gulten Okmen
BACKGROUND: Staphylococcus aureus is the direct reason of mastitis. Mastitis is a disease characterized by pathological changes in mammary glands as well as physical, chemical, bacteriological changes in milk. This disease causes loses in milk yield and quality. In recent years, it is reported that mastitis pathogens have developed a resistance to antibiotics as a natural consequence of widespread use of it. Today's researches are focused on discovering and using new antibiotics against bacteria...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28565778/value-of-a-new-pathological-classification-of-lumbar-intervertebral-disc-herniation-based-on-transforaminal-endoscopic-observations
#15
Lin Yang, Hong-Hui Lu
Removal of herniated disc materials based on an imaging only method may not relieve symptoms in many patients. Therefore, the aim of the present study was to develop a transforaminal endoscopic method of classifying the pathological type of lumber intervertebral disc herniation and to compare the outcomes of surgery based on the pathological type with those of conventional endoscopic disc removal. The records of patients who received endoscopic transforaminal nucleotomy with foraminoplasty for symptomatic lumbar disc herniation between 2009 and 2013 were retrospectively reviewed...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28564701/the-impact-of-lens-opacity-on-sd-oct-retinal-nerve-fiber-layer-and-bruch-s-membrane-opening-measurements-using-the-anatomical-positioning-system-aps
#16
Matthias M Mauschitz, Felix Roth, Frank G Holz, Monique M B Breteler, Robert P Finger
Purpose: To evaluate the impact of lens opacity on retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening (BMO) measurements. Methods: Fifty-nine randomly selected patients without any other relevant ocular pathology undergoing elective routine cataract surgery in two specialized eye clinics were enrolled. RNFLT, BMO area, and BMO minimum rim width (BMO-MRW) were assessed with the Heidelberg Engineering Spectralis OCT using the anatomical positioning system (APS) prior to and 1 day after cataract surgery using a ring scan at different eccentricities of the disc (3...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28564667/rhode-island-hospital-s-contribution-to-the-field-of-endoscopic-spine-surgery
#17
Albert E Telfeian, Adetokunbo A Oyelese, Ziya L Gokaslan
The first academic program in endoscopic spine surgery in the United States opened its doors at Rhode Island Hospital in 2012. Published advances in the field since its inception have included treatments for a myriad of pathologies including lumbar and thoracic disc herniations, spondylolisthesis, spine tumors as well as treatments for complications of other spinal procedures including spinal fusion, kyphoplasty, and total disc replacement. In this issue of the Rhode Island Medical Journal we summarize the history of the procedure as well as some of the interesting progress going on in this field in Rhode Island...
June 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28562533/mirnas-as-biomarkers-for-diagnosis-of-heart-failure-a-systematic-review-and-meta-analysis
#18
Hualin Yan, Fan Ma, Yi Zhang, Chuan Wang, Dajian Qiu, Kaiyu Zhou, Yimin Hua, Yifei Li
BACKGROUND: With the rapid development of molecular biology, the kind of mircoRNA (miRNA) has been introduced into emerging role both in cardiac development and pathological procedure. Thus, we conduct this meta-analysis to find out the role of circulating miRNA as a biomarker in detecting heart failure. METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and World Health Organization clinical trials registry center to identify relevant studies up to August 2016...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28557967/-the-assessment-of-the-impact-of-rehabilitation-on-the-pain-intensity-level-in-patients-with-herniated-nucleus-pulposus-of-the-intervertebral-disc
#19
Kamil Koszela, Sylwia Krukowska, Marta Woldańska-Okońska
Back pain may be caused by many factors. In many cases it is difficult to unambiguously determine a cause of the pathology, which can involve various structures in the spine. In this paper we will discuss the symptoms associated with the degenerative changes of the intervertebral disc, which involve, among others, its bulging, dislocation and pressure on the surrounding structures. These problems require an adequate clinical and imaging diagnostics in order to implement an appropriate treatment. In the first place, it should be based on the conservative methods (such as: pharmacotherapy, rehabilitation and lifestyle changes)...
May 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28555457/-situs-inversus-of-the-optic-nerve-a-case-report
#20
I Lopez-Cuenca, R de Hoz, E Salobrar-Garcia, B Rojas, A I Ramirez, J J Salazar, A Trivino, J M Ramirez
INTRODUCTION: Situs inversus of the optic nerve is a congenital anomaly characterised by the emergence of the vessels in the retina towards the nose rather than in a temporal direction. It is caused by an anomalous insertion of the optic stalks into the optic vesicle that gives rise to dysversion of the head of the optic nerve. It is not an isolated condition and usually appears jointly with tilted disc syndrome and in patients with myopia. It is characterised by the presence of inferior conus atrophy, deficiencies in the temporal visual field, refraction defects and ambliopy...
June 1, 2017: Revista de Neurologia
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