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Disc pathology

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https://www.readbyqxmd.com/read/28927213/ten-step-minimally-invasive-spine-lumbar-decompression-and-dural-repair-through-tubular-retractors
#1
Mohamed Abdelatif Boukebir, Connor David Berlin, Rodrigo Navarro-Ramirez, Tim Heiland, Karsten Schöller, Cameron Rawanduzy, Sertaç Kirnaz, Ajit Jada, Roger Härtl
BACKGROUND: Minimally invasive spine (MIS) surgery utilizing tubular retractors has become an increasingly popular approach for decompression in the lumbar spine. However, a better understanding of appropriate indications, efficacious surgical techniques, limitations, and complication management is required to effectively teach the procedure and to facilitate the learning curve. OBJECTIVE: To describe our experience and recommendations regarding tubular surgery for lumbar disc herniations, foraminal compression with unilateral radiculopathy, lumbar spinal stenosis, synovial cysts, and dural repair...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28924440/swollen-optic-disc-and-sinusitis
#2
Chiara Del Noce, Filippo Marchi, Giacomo Sollini, Michele Iester
PURPOSE: To present a case of optic disc swelling caused by sinusitis. METHODS: Ocular symptoms were investigated using computed tomography imaging of the facial bones to detect the relationship between the sinus inflammation and the optic nerve. RESULTS: A particular configuration of the optic nerve was detected. Optic nerve course through the inflamed sphenoidal sinus is a condition associated with a greater risk of inflammation. CONCLUSION: Sinusitis is a rare but treatable cause of optic neuritis...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28915718/the-pi3k-akt-pathway-a-critical-player-in-intervertebral-disc-degeneration
#3
REVIEW
Zhi-Hua Ouyang, Wen-Jun Wang, Yi-Guo Yan, Bing Wang, Guo-Hua Lv
Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912514/retinal-changes-following-rapid-ascent-to-a-high-altitude-environment
#4
X Tian, B Zhang, Y Jia, C Wang, Q Li
PurposeTo determine what impact rapid ascension to a high-altitude environment has on the retina with the aim of preventing and treating high-altitude oculopathy.Patients and methodsParticipants in the study were members of the Chinese military assigned to the high-altitude environment of the Tibetan plateau. Ninety-one participants were enrolled in the study. Optical coherence tomography was used to measure the thickness of retina-related indicators. Measurements were taken before and after exposure to the high-altitude environment and upon return to the baseline altitude...
September 15, 2017: Eye
https://www.readbyqxmd.com/read/28888674/geographical-variations-in-clinical-presentation-and-outcomes-of-decompressive-surgery-in-patients-with-symptomatic-degenerative-cervical-myelopathy-analysis-of-a-prospective-international-multicenter-cohort-study-of-757-patients
#5
Michael G Fehlings, Branko Kopjar, Ahmed Ibrahim, Lindsay A Tetreault, Paul M Arnold, Helton Defino, Shashank Sharad Kale, S Tim Yoon, Giuseppe M Barbagallo, Ronald H M Bartels, Qiang Zhou, Alexander R Vaccaro, Mehmet Zileli, Gamaliel Tan, Yasutsugu Yukawa, Darrel S Brodke, Christopher I Shaffrey, Osmar Santos de Moraes, Eric J Woodard, Massimo Scerrati, Masato Tanaka, Tomoaki Toyone, Rick C Sasso, Michael E Janssen, Ziya L Gokaslan, Manuel Alvarado, Ciaran Bolger, Christopher M Bono, Mark B Dekutoski
BACKGROUND CONTEXT: Degenerative cervical myelopathy (DCM) is a progressive degenerative spine disease and the most common cause of spinal cord impairment in adults worldwide. There is a paucity of studies reporting on regional variations in demographics, clinical presentation, disease causation and surgical effectiveness. PURPOSE: To evaluate differences in demographics, causative pathology, management strategies, surgical outcomes, length of hospital stay and complications across four geographic regions...
September 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28881110/endoscopic-spine-surgery
#6
REVIEW
Gun Choi, Chetan S Pophale, Bhupesh Patel, Priyank Uniyal
Surgical treatment of the degenerative disc disease has evolved from traditional open spine surgery to minimally invasive spine surgery including endoscopic spine surgery. Constant improvement in the imaging modality especially with introduction of the magnetic resonance imaging, it is possible to identify culprit degenerated disc segment and again with the discography it is possible to diagnose the pain generator and pathological degenerated disc very precisely and its treatment with minimally invasive approach...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28870505/tgf-%C3%AE-1-affects-cell-cell-adhesion-in-the-heart-in-an-ncam1-dependent-mechanism
#7
Maegen A Ackermann, Jennifer M Petrosino, Heather R Manring, Patrick Wright, Vikram Shettigar, Ahmet Kilic, Paul M L Janssen, Mark T Ziolo, Federica Accornero
The contractile property of the myocardium is maintained by cell-cell junctions enabling cardiomyocytes to work as a syncytium. Alterations in cell-cell junctions are observed in heart failure, a disease characterized by the activation of Transforming Growth Factor beta 1 (TGFβ1). While TGFβ1 has been implicated in diverse biologic responses, its molecular function in controlling cell-cell adhesion in the heart has never been investigated. Cardiac-specific transgenic mice expressing active TGFβ1 were generated to model the observed increase in activity in the failing heart...
September 1, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28866262/groin-pain-associated-with-sacroiliac-joint-dysfunction-and-lumbar-disorders
#8
Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa
OBJECTIVE: We investigated the prevalence of groin pain in patients with sacroiliac joint (SIJ) dysfunction, lumbar spinal canal stenosis (LSS), and lumbar disc herniation (LDH) who did not have hip disorders, and evaluated the clinical features that distinguished SIJ dysfunction from LSS and LDH. PATIENT AND METHODS: We evaluated 127 patients (57 men, 70 women, average age 55 years) with SIJ dysfunction, 146 (98 men, 48 women, average age 71 years) with LSS, and 124 (83 men, 41 women, average age 50 years) with LDH...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28865227/pathological-findings-in-low-field-magnetic-resonance-imaging-of-the-canine-spine-a-study-of-112-patients
#9
P Holak, J Głodek, M Mieszkowska, M Jałyński, Y Zhalniarovich, Z Adamiak
Magnetic resonance imaging (MRI) is a method of choice in diagnosing nervous system disorders. This paper presents the results of a study where selected segments of the canine spine were examined by low-field MRI in 112 patients. Images of pathological changes were obtained in spin echo (SE), fast spin echo (FSE) and hybrid contrast enhancement (3D HYCE) sequences. The cervical region of the spinal cord (C1-C5) was examined in 32 patients, the cervicothoracic region (C6-Th2)- in 14 patients, the thoracolumbar region (Th3-L3) - in 23 patients, and the lumbosacral region (L4-S3) - in 43 patients...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28865203/pharmacological-and-phytochemical-screening-of-palestinian-traditional-medicinal-plants-erodium-laciniatum-and-lactuca-orientalis
#10
Nidal Jaradat, Motasem AlMasri, Abdel Naser Zaid, Dua'a Ghazi Othman
BACKGROUND: Various epidemiological studies showed that herbal remedies containing polyphenols may protect against various diseases such as cancers, vascular diseases and inflammatory pathologies. Currently, such groups of bioactive compounds have become a subject of many antimicrobials and antioxidant investigations. Accordingly, the current study aimed to conduct biological and phytochemical screening for two Palestinian traditional medicinal plants, Erodium laciniatum and Lactuca orientalis...
September 1, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28842234/t1-t2-herniated-disc-presenting-with-horner-s-syndrome
#11
Joaquim C Teixeira, Maria M Santos, João L Melancia
BACKGROUND: The incidence of thoracic disc herniation (TDH) is estimated to be 1,000 to 1,000,000. Upper thoracic disc herniation is an exceedingly rare pathology with unique neurological features. We report a case of a young patient who presented with Horner's Syndrome causedd by a T1-T2 disc herniation CASE DESCRIPTION: A 34-year-old female patient was admitted to the emergency department presenting a sudden onset history of ptosis and miosis on the left eye (Horner's Syndrome). She reported a 2-month history of neck, scapular and medial left arm and forearm pain and numbness...
August 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28839319/spinal-cord-injury-without-radiographic-abnormality-sciwora-in-adults-a-report-of-two-cases
#12
Adil Aziz Khan, Shafaq Mahmood, Tayyaba Saif, Aleesha Gul
Spinal cord injury without any radiographic abnormality (SCIWORA) is rare in adults. We describe here two case reports of adult patients, who presented to us with quadriplegia, following a road traffic accident. Plain radiography and computed tomography (CT) of cervical spine were normal. Hence the patients were diagnosed as cases of adult SCIWORA. However, subsequent magnetic resonance imaging (MRI) of the two patients revealed cervical cord injury in the form of cord contusion and disc protrusion, respectively...
August 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28836092/four-symptoms-define-the-piriformis-syndrome-an-updated-systematic-review-of-its-clinical-features
#13
REVIEW
Kevork Hopayian, Armine Danielyan
PURPOSE: To update the evidence on the clinical features of the piriformis syndrome since the first systematic review published in 2010. METHOD: A systematic review of all case, cross-sectional and prevalence studies. RESULTS: The commonest features reported were: buttock pain, pain aggravated on sitting, external tenderness near the greater sciatic notch and pain on any maneuver that increases piriformis muscle tension, and limitation of straight leg raising...
August 23, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28817389/congenital-anomalies-of-the-optic-disc-insights-from-optical-coherence-tomography-imaging
#14
Karen W Jeng-Miller, Dean M Cestari, Eric D Gaier
PURPOSE OF REVIEW: Congenital anomalies of the optic nerve are rare but significant causes of visual dysfunction in children and adults. Accurate diagnosis is dependent on a thorough funduscopic examination, but can be enhanced by imaging information garnered from optical coherence tomography (OCT). We review common congenital optic nerve anomalies, including optic disc pit, optic nerve coloboma, morning glory disc anomaly, and hypoplasia of the optic nerve, review their systemic associations, and discuss insights from OCT imaging...
August 16, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28810627/carthamin-yellow-inhibits-matrix-degradation-and-inflammation-induced-by-lps-in-the-intervertebral-disc-via-suppression-of-mapk-pathway-activation
#15
Bin Chen, Han-Tao Wang, Bo Yu, Ji-Dong Zhang, Yu Feng
Carthamin yellow (CY), which is a flavonoid compound isolated from safflower, has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. CY is a herb used in Chinese traditional medicines. Intervertebral disc degeneration (IDD) is a common spinal disorder and degeneration of nucleus pulposus (NP) cells and inflammation are significant parts of the pathological cascade. The curative effect of CY on NP cells in association with degeneration and inflammation remains to be elucidated...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808602/high-lumbar-noninstrumented-fusion-rates-using-lamina-autograft-and-nanoss-bone-marrow-aspirate
#16
Nancy E Epstein
BACKGROUND: Patients with marked osteoporosis and/or obesity/morbid obesity and severe multilevel lumbar stenosis and other pathology often undergo multilevel laminectomies with non instrumented posterolateral fusions (PLF). The other pathology may include combinations of degenerative spondylolisthesis/lysis, foraminal/far lateral discs, and/or synovial cysts requiring more extensive facet resections. Presently, spine surgeons often use bone graft expanders to supplement the lamina autograft harvested in the course of laminectomy/decompressions for the PLF mass...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28796755/the-effect-of-lumbar-disc-herniation-on-musculoskeletal-loadings-in-the-spinal-region-during-level-walking-and-stair-climbing
#17
Shengzheng Kuai, Zhenhua Liao, Wenyu Zhou, Xinyu Guan, Run Ji, Rui Zhang, Daiqi Guo, Weiqiang Liu
BACKGROUND People with low back pain (LBP) alter their motion patterns during level walking and stair climbing due to pain or fear. However, the alternations of load sharing during the two activities are largely unknown. The objective of this study was to investigate the effect of LBP caused by lumbar disc herniation (LDH) on the muscle activities of 17 main trunk muscle groups and the intradiscal forces acting on the five lumbar discs. MATERIAL AND METHODS Twenty-six healthy adults and seven LDH patients were recruited to perform level walking and stair climbing in the Gait Analysis Laboratory...
August 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28796049/tophaceous-gout-causing-lumbar-stenosis-a-case-report
#18
Huigen Lu, Jianming Sheng, Jiaping Dai, Xuqi Hu
RATIONALE: Gout in the spine is very rare. The clinical symptoms of the spinal gout are various and lack of specificity. The authors report a case of spinal gout causing lumbar stenosis. We never find such wide-invasive spinal gouty lesion in the published studies. PATIENT CONCERNS: A 68-year-old male had low back pain radiating to bilateral lower limbs, accompanying with intermittent claudication that lasted for 3 months and aggravated 5 days ago. DIAGNOSES: Spinal gout, lumbar stenosis...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28793005/the-diagnostic-value-of-narrow-band-imaging-for-early-and-invasive-lung-cancer-a-meta-analysis
#19
Juanjuan Zhu, Wei Li, Jihong Zhou, Yuqing Chen, Chenling Zhao, Ting Zhang, Wenjia Peng, Xiaojing Wang
This study aimed to compare the ability of narrow-band imaging to detect early and invasive lung cancer with that of conventional pathological analysis and white-light bronchoscopy. We searched the PubMed, EMBASE, Sinomed, and China National Knowledge Infrastructure databases for relevant studies. Meta-disc software was used to perform data analysis, meta-regression analysis, sensitivity analysis, and heterogeneity testing, and STATA software was used to determine if publication bias was present, as well as to calculate the relative risks for the sensitivity and specificity of narrow-band imaging vs those of white-light bronchoscopy for the detection of early and invasive lung cancer...
July 2017: Clinics
https://www.readbyqxmd.com/read/28791354/collagen-type-ii-is-downregulated-in-the-degenerative-nucleus-pulposus-and-contributes-to-the-degeneration-and-apoptosis-of-human-nucleus-pulposus-cells
#20
Chengjie Lian, Bo Gao, Zizhao Wu, Xianjian Qiu, Yan Peng, Anjing Liang, Caixia Xu, Peiqiang Su, Dongsheng Huang
Degenerative disc disease (DDD) is a common degenerative condition initiated mainly within the nucleus pulposus (NP). To date, the etiopathogenesis of DDD remains unclear, and because no effective therapeutic strategies are available to target its pathological processes, DDD is still treated with symptomatic interventions that are far from adequate. Collagen type II is one of the major matrix components of the NP, and is considered to be essential to NP homeostasis. However, the specific mechanisms by which collagen type II influences NP cells remain unknown...
October 2017: Molecular Medicine Reports
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