keyword
MENU ▼
Read by QxMD icon Read
search

Disc pathology

keyword
https://www.readbyqxmd.com/read/29784673/formation-of-the-sacrum-requires-down-regulation-of-sonic-hedgehog-signaling-in-the-sacral-intervertebral-discs
#1
Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae during childhood, and their fusion to form a single bone. We show that collapse of the sacral discs in the mouse is associated with the down-regulation of sonic hedgehog (SHH) signaling in the nucleus pulposus (NP) of the disc, and many aspects of this phenotype can be reversed by experimental postnatal activation of HH signaling...
May 21, 2018: Biology Open
https://www.readbyqxmd.com/read/29784013/vegf-vascularization-pathway-in-human-intervertebral-disc-does-not-change-during-the-disc-degeneration-process
#2
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V Stoyanov
OBJECTIVE: During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth factor receptor 1, while shorter soluble forms of this receptor can inhibit vascularization. We hypothesized that membrane and soluble receptor forms might change between stages of intervertebral disc degeneration. RESULTS: Expression of soluble and membrane forms of vascular endothelial growth factor receptor 1 in human degenerated intervertebral discs and healthy bovine caudal discs was assessed by qRT-PCR and immunoblot...
May 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29780936/clinical-and-pathological-correlation-of-cotton-wool-spots-in-secondary-angle-closure-glaucoma
#3
Anand Bhatt, Christine Nguyen, Sameh Mosaed, Don Minckler
Purpose: Cotton Wool Spots (CWS) are a commonly described retinal finding in the posterior segment associated with an extensive number of systemic diseases. The appearance of a CWS in the setting of glaucoma has rarely been reported and has not been correlated with pathology to localized loss of the nerve fiber layer previously. In this case report, we augment a previous report of an 18 year old female with a diagnosis of low grade ciliary body melanoma. This patient experienced eventual mechanical angle closure with a CWS appearing in the posterior pole in the setting of acute elevation of intraocular pressure (IOP)...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29764480/a-stepped-approach-for-the-management-of-symptomatic-internal-derangement-of-the-temporomandibular-joint
#4
Candan Efeoglu, Aylin Sipahi Calis, Huseyin Koca, Esra Yuksel
BACKGROUND: Internal derangement is the clinical and pathological condition of disc displacement of the temporomandibular joint. Management of these cases involve conservative and surgical treatment options. Minimally invasive surgical procedures namely arthrocentesis and arthroscopy are promising techniques in the management of internal derangement. However patient selection algorithms, indications for minimally invasive procedures and details of the techniques should be further studied for safe and cost effective management of these cases...
May 15, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29755274/nut-carcinoma-of-the-sinonasal-tract-infiltrating-the-orbit-in-a-man-with-birdshot-chorioretinitis
#5
Wesley Chan, Martin J Bullock, Arif F Samad, Curtis W Archibald, J Godfrey Heathcote
A 48-year-old man with a history of birdshot chorioretinitis presented with blurry vision, retro-bulbar pain and sinusitis. Though visual acuity was unaffected, he had left optic disc oedema and mild restriction of left eye abduction. His symptoms progressed quickly, with diplopia in primary gaze, epistaxis from his left nostril, and a left relative afferent pupillary defect (RAPD). On computed tomography, there was a mass in the nasal cavity that extended through the left cribriform plate and lamina papyracea and posteriorly into the optic canal...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29752339/resveratrol-enhances-matrix-biosynthesis-of-nucleus-pulposus-cells-through-activating-autophagy-via-the-pi3k-akt-pathway-under-oxidative-damage
#6
Jinlou Gao, Qingyun Zhang, Lin Song
BACKGROUND: The decrease in nucleus pulposus (NP) matrix production is a classic  feature during disc degeneration. Resveratrol (RSV) is reported to play protective effects under many pathological factors. OBJECTIVE: This study aims to study the effects of RSV on NP matrix homeostasis under oxidative damage and the potential mechanism. METHODS: Rat NP cells were exposed to H2 O2 solution to create an oxidative damage. RSV and the 3‑Methyladenine (3-MA) was added along with the culture medium to respectively investigate the role of RSV and cellular autophagy...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29745733/anterior-cervical-approach-for-the-treatment-of-axial-or-high-thoracic-levels
#7
Ran Harel, Maya Nulman, Zvi R Cohen, Nachshon Knoller
PURPOSE: Application of the anterior sub-axial cervical approach to the axial spine or the high thoracic spine has been previously described. Evaluation methods to determine the feasibility of these approaches were also described but alternative method was utilized in the current study. We describe our experience expanding the boundaries of anterior cervical approach utilizing a novel algorithm for approach selection. MATERIALS AND METHODS: A retrospective analysis of patients' files and imaging data of all anterior cervical approach to treat pathologies above C2-3 disc space or below C7-D1 disc space...
May 10, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29740745/a-novel-method-for-retinal-optic-disc-detection-using-bat-meta-heuristic-algorithm
#8
Ahmad S Abdullah, Yasa Ekşioğlu Özok, Javad Rahebi
Normally, the optic disc detection of retinal images is useful during the treatment of glaucoma and diabetic retinopathy. In this paper, the novel preprocessing of a retinal image with a bat algorithm (BA) optimization is proposed to detect the optic disc of the retinal image. As the optic disk is a bright area and the vessels that emerge from it are dark, these facts lead to the selected segments being regions with a great diversity of intensity, which does not usually happen in pathological regions. First, in the preprocessing stage, the image is fully converted into a gray image using a gray scale conversion, and then morphological operations are implemented in order to remove dark elements such as blood vessels, from the images...
May 9, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29732419/complications-following-single-level-interbody-fusion-procedures-an-acs-nsqip-study
#9
Jamal N Shillingford, Joseph L Laratta, Joseph M Lombardi, John D Mueller, Meghan Cerpa, Hemant P Reddy, Comron Saifi, Charla R Fischer, Ronald A Lehman
Background: Controversy exists over the ability of various lumbar interbody fusion techniques to realign global and regional balance and their effect on patient outcomes. This is a retrospective cohort study to compare thirty-day postoperative outcomes between anterior and posterior interbody fusion techniques within a large national database. Methods: A retrospective cohort study utilizing the National Surgical Quality Improvement Program (NSQIP) database included 2,372 (29...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29731814/morphology-of-the-lumbar-multifidus-muscle-in-lumbar-disc-herniation-at-different-durations-and-at-different-ages
#10
Zhi-Neng Chen, Xin-Miao Yao, Yi Lv, Bang-Jiang He, Jun-Cai Ye, Rong-Xue Shao, Huang-Wei Jiang
The aim of the present study was to evaluate the relative functional volume of bilateral lumbar multifidus (LM) muscles across different stages and ages of patients with lumbar disc herniation (LDH). The relative functional volumes of LM muscles in both non-affected and affected sides in the L4-L5 and L5-S1 segmental level were measured in a resting prone position, and visual analogue score (VAS) for pain and Japanese Orthopedic Association (JOA) scores were recorded. The correlation between changes in the relative net volume of LM muscles and times of onset, ages, VAS and JOA scores were analyzed...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29731282/rethinking-reverse-cholesterol-transport-and-dysfunctional-high-density-lipoproteins
#11
REVIEW
Baiba K Gillard, Corina Rosales, Bingqing Xu, Antonio M Gotto, Henry J Pownall
Human plasma high-density lipoprotein cholesterol concentrations are a negative risk factor for atherosclerosis-linked cardiovascular disease. Pharmacological attempts to reduce atherosclerotic cardiovascular disease by increasing plasma high-density lipoprotein cholesterol have been disappointing so that recent research has shifted from HDL quantity to HDL quality, that is, functional vs dysfunctional HDL. HDL has varying degrees of dysfunction reflected in impaired reverse cholesterol transport (RCT). In the context of atheroprotection, RCT occurs by 2 mechanisms: one is the well-known trans-hepatic pathway comprising macrophage free cholesterol (FC) efflux, which produces early forms of FC-rich nascent HDL (nHDL)...
April 12, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29729280/molecular-dynamics-simulations-of-lipid-nanodiscs
#12
Mohsen Pourmousa, Richard W Pastor
A lipid nanodisc is a discoidal lipid bilayer stabilized by proteins, peptides, or polymers on its edge. Nanodiscs have two important connections to structural biology. The first is associated with high-density lipoprotein (HDL), a particle with a variety of functionalities including lipid transport. Nascent HDL (nHDL) is a nanodisc stabilized by Apolipoprotein A-I (APOA1). Determining the structure of APOA1 and its mimetic peptides in nanodiscs is crucial to understanding pathologies related to HDL maturation and designing effective therapies...
May 2, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29729161/antimicrobial-susceptibility-patterns-of-escherichia-coli-in-children-and-adults-with-urinary-tract-infections
#13
Yaroslav O Mykhalko
OBJECTIVE: Introduction: Urinary tract infections (UTIs) are common pathology in children and adults that is caused mainly by Gram-negative bacteria among which Escherichia coli plays an outstanding role. UTIs treatment demands empiric antibiotic therapy and knowing of antimicrobial local susceptibility and resistance patterns is crucial for making a decision about an agent for the first line therapy. The aim of this study was to evaluate the local susceptibility patterns of uropathogenic E...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29721455/full-field-in-vitro-investigation-of-hard-and-soft-tissue-strain-in-the-spine-by-means-of-digital-image-correlation
#14
REVIEW
Maria Luisa Ruspi, Marco Palanca, Cesare Faldini, Luca Cristofolini
Introduction: The spine deserves careful biomechanical investigation, because of the different types of degeneration deriving from daily stress, trauma, and hard and soft tissue pathologies. Many biomechanical studies evaluated the range of motion, structural stiffness of spine segments under different loading conditions, without addressing the strain distribution. Strain gauges have been used to measure strain in the vertebral body, in a pointwise way.What is currently missing is a method to measure the distribution of strain in the soft tissues (intervertebral discs and ligaments), and an integration between measurements in the hard and soft tissues...
October 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29717369/molecular-identification-of-trichodina-compacta-van-as-and-basson-1989-ciliophora-peritrichia-from-cultured-oreochromis-niloticus-in-egypt-and-its-impact-on-immune-responses-and-tissue-pathology
#15
Nevien K Abdelkhalek, Mohamed A El-Adl, Mohamed F Salama, Bassem Elmishmishy, Mayar O Ali, Ahmed El-Ashram, Mohamed F Hamed, Moustafa A Al-Araby
Trichodinids are peritrichous ciliated protozoa that affect both wild and cultured fishes. Several Trichodina species have low host specificity and are morphologically distinct, facilitating their identification based primarily on the presence of adhesive discs and the number of attached denticles. A trichodinid species named Trichodina compacta was first reported by Van As and Basson (1989) (Protozoa: Ciliophora: Peritrichia). However, in trichodinid infestations, morphological characteristics are insufficient for identifying the infesting species...
May 1, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29713407/the-incidence-of-adjacent-segment-degeneration-after-the-use-of-a-versatile-dynamic-hybrid-stabilization-device-in-lumbar-stenosis-results-of-a-5-8-year-follow-up
#16
Mauro Dobran, Davide Nasi, Domenico Paolo Esposito, Maurizio Gladi, Massimo Scerrati, Maurizio Iacoangeli
Study Design: Retrospective study with long-term follow-up. Purpose: To evaluate the long-term incidence of adjacent segment degeneration (ASD) and clinical outcomes in a consecutive series of patients who underwent spinal decompression associated with dynamic or hybrid stabilization with a Flex+TM stabilization system (SpineVision, Antony, France) for lumbar spinal stenosis. Overview of Literature: The incidence of ASD and clinical outcomes following dynamic or hybrid stabilization with the Flex+TM system used for lumbar spinal stenosis have not been well investigated...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29707555/lumbar-disc-reherniation-after-transforaminal-lumbar-endoscopic-discectomy
#17
Thomas A Kosztowski, David Choi, Jared Fridley, Michael Galgano, Ziya Gokaslan, Adetokunbo Oyelese, Albert Edward Telfeian
Background: Transforaminal lumbar endoscopic discectomy is a minimally invasive surgical procedure that can be performed in awake patients through an incision less than 1 cm. The procedure requires very little bony removal to access the herniated disc material because the approach is through the foramen, and only a small amount of the superior articulating process is removed to access Kambin's triangle. This study describes our experience with transforaminal endoscopic lumbar decompression (TELD) for the treatment of lumbar disc herniation...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29707549/percutaneous-endoscopic-cervical-discectomy-a-technical-review
#18
REVIEW
Javier Quillo-Olvera, Guang-Xun Lin, Jin-Sung Kim
The treatment of cervical disc herniations has evolved in the last 2 decades. While the anterior cervical discectomy and fusion continues being the gold standard for the treatment of radicular pain triggered by cervical disc herniation, other surgical approaches have been developed. Percutaneous endoscopic cervical discectomy has demonstrated the ability to decompress the exiting nerve root and dural sac correctly and encouraging clinical outcomes has been reported in the literature. One of the most important advantages offered by the endoscopic technique is the capability to resolve the patient's symptoms without the need for interbody fusion...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29697601/lordosis-re-creation-in-tlif-and-plif-a-cadaveric-study-of-the-influence-of-surgical-bone-resection-and-cage-angle
#19
Peter A Robertson, William A Armstrong, Daniel L Woods, Jeremy J Rawlinson
STUDY DESIGN: Controlled cadaveric study of surgical technique in Transforaminal and Posterior Lumbar Interbody Fusion (TLIF & PLIF) OBJECTIVE.: To evaluate the contribution of surgical techniques and cage variables in lordosis re-creation in posterior interbody fusion (TLIF/PLIF). SUMMARY OF BACKGROUND DATA: The major contributors to lumbar lordosis are the lordotic lower lumbar discs. The pathologies requiring treatment with segmental fusion are frequently hypolordotic or kyphotic...
April 24, 2018: Spine
https://www.readbyqxmd.com/read/29681489/video-diversion-improves-success-rate-of-fundoscopic-examination-in-children-a-prospective-randomized-controlled-trial
#20
Michael M H Yang, Ash Singhal, Alexander R Hengel, John M Kerr, Godefroy Hardy St-Pierre, Shawn George, Katherine Muir, Paul Thiessen, Paul Enarson
BACKGROUND: Fundoscopy is an important component of the neurological examination as it can detect pathologies such as high intracranial pressure. However, the examination can be challenging in young children. This study evaluated whether playing a video during eye examination improves the success, duration, and ease of pediatric fundoscopy. MATERIALS AND METHODS: This was a prospective, multipractitioner, multiclinic, randomized controlled trial. Patients aged one to four years were recruited in the emergency department, neurology clinic, spinal cord clinic, and general pediatric clinic...
September 14, 2017: Pediatric Neurology
keyword
keyword
106900
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"