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Palliative gastrectomy

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https://www.readbyqxmd.com/read/29150634/incomplete-resection-and-linitis-plastica-are-factors-for-poor-survival-after-extended-multiorgan-resection-in-gastric-cancer-patients
#1
Hua Xiao, Min Ma, Yanping Xiao, Yongzhong Ouyang, Ming Tang, Kunyan Zhou, Yuan Hong, Bo Tang, Chaohui Zuo
The aim of this retrospective study was to analyze the morbidity, mortality, and survival rates of extended multiorgan resection (EMR) for locally advanced gastric cancer patients compared to gastrectomy alone and a palliative operation. 893 locally advanced gastric cancer patients without distant metastasis had surgery including gastrectomy alone (GA group, n = 798), EMR resection (EMR group, n = 75), and palliative operation (palliative gastrectomy or gastrojejunostomy (PO group, n = 20)). Postoperative mortality and complication rates in the EMR group were significantly higher than in the GA group (2...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29124550/gastrectomy-with-extended-lymphadenectomy-a-north-american-perspective
#2
Alexandre Gosselin-Tardif, Jessica Lie, Ioana Nicolau, Juan Carlos Molina, Jonathan Cools-Lartigue, Liane Feldman, Jonathan Spicer, Carmen Mueller, Lorenzo Ferri
PURPOSE: Despite evidence of oncologic benefits from extended (D2) lymphadenectomy in gastric cancer from many East Asian studies, there is persistent debate over its use in the West, mainly due to perceived high rates of morbidity and mortality. This study evaluates the safety and efficacy of D2 dissection in a high-volume North American center. METHODS: A prospectively entered database of all patients undergoing gastrectomy for cancer at a North American referral center from 2005 to 2016 was reviewed...
November 9, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29050356/negative-lymph-node-count-is-a-significant-prognostic-factor-in-patient-with-stage-iv-gastric-cancer-after-palliative-gastrectomy
#3
Changhua Zhuo, Mingang Ying, Ruirong Lin, Xianyi Wu, Shen Guan, Chunkang Yang
Negative lymph node (NLN) count has been validated as a protective predictor in various cancers after radical resection. However, the prognostic value of NLN count in the setting of stage IV gastric cancer patients who have received palliative resection has not been investigated. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Kaplan-Meier survival curves and multivariate Cox proportional hazards model were used to assess the risk factors for patients' survivals...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977910/evaluation-of-hepatectomy-and-palliative-local-treatments-for-gastric-cancer-patients-with-liver-metastases-a-propensity-score-matching-analysis
#4
Jiyang Li, Kecheng Zhang, Yunhe Gao, Hongqing Xi, Jianxin Cui, Wenquan Liang, Aizhen Cai, Bo Wei, Lin Chen
BACKGROUND: The optimal treatments for gastric cancer with liver metastases (GCLM) remain controversial. This study aimed to evaluate the efficacy of hepatectomy, RFA and TACE as local treatments for GCLM. METHODS: From 2001 to 2015, 119 consecutive patients who received multidisciplinary treatments based on curative gastrectomy and local treatments (hepatectomy, RFA and TACE) for liver metastases were enrolled in this retrospective cohort study. Patients were divided into Group A (46, hepatectomy) and Group B (73, either or both RFA and TACE)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976226/selecting-patients-for-gastrectomy-in-metastatic-esophago-gastric-cancer-clinics-and-pathology-are-not-enough
#5
Lorenzo Fornaro, Valentina Fanotto, Gianna Musettini, Mario Uccello, Lorenza Rimassa, Caterina Vivaldi, Caterina Fontanella, Francesco Leone, Riccardo Giampieri, Gerardo Rosati, Monica Lencioni, Daniele Santini, Samantha Di Donato, Gianluca Tomasello, Oronzo Brunetti, Filippo Pietrantonio, Francesca Bergamo, Mario Scartozzi, Antonio Avallone, Stefania Eufemia Lutrino, Davide Melisi, Lorenzo Antonuzzo, Antonio Pellegrino, Lorenzo Gerratana, Stefano Cordio, Enrico Vasile, Giuseppe Aprile
AIM: To evaluate the impact on overall survival (OS) of gastrectomy in asymptomatic metastatic esophago-gastric cancer. PATIENTS & METHODS:  Five hundred and thirteen patients were included. The role of surgery and other clinico-pathological factors was evaluated by univariate and Cox regression analyses. OS was the primary end point. RESULTS: Multivariate analysis confirmed that gastrectomy was a predictor of longer OS (p < 0.001), as well as preserved performance status and benefit from first-line chemotherapy...
October 4, 2017: Future Oncology
https://www.readbyqxmd.com/read/28819425/selective-gastric-cancer-patients-with-peritoneal-seeding-benefit-from-gastrectomy-after-palliative-chemotherapy-a-propensity-score-matching-analysis
#6
Shu-Qiang Yuan, Run-Cong Nie, Shi Chen, Xiao-Jiang Chen, Yong-Ming Chen, Li-Pu Xu, Li-Fang Yang, Zhi-Wei Zhou, Jun-Sheng Peng, Ying-Bo Chen
Background: The present study aimed to explore whether gastric cancer patients with peritoneal seeding after receiving palliative chemotherapy could benefit from gastrectomy and to identify patients with peritoneal seeding who should be selected to receive gastrectomy. Methods: A total of 201 gastric cancer patients were diagnosed with peritoneal seeding and received palliative chemotherapy. Propensity score matching (PSM) was performed to balance the selection bias. Results: After PSM, compared with non-gastrectomy group, gastrectomy group had a longer median overall survival (OS) (23...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28759654/surgical-resection-of-metachronous-hepatic-metastases-from-gastric-cancer-improves-long-term-survival-a-population-based-study
#7
Szu-Chin Li, Cheng-Hung Lee, Chung-Lin Hung, Jin-Chia Wu, Jian-Han Chen
INTRODUCTION: Hepatic metastases are diagnosed synchronously in 3-14% of patients with gastric cancer, and metachronously in up to 37% of patients following ''curative" gastrectomy. Most patients who have gastric cancer and hepatic metastasis are traditionally treated with palliative chemotherapy. The impact of liver resection is still controversial. We attempted to assess whether liver resection can improve survival in cases of metachronous hepatic metastases from gastric cancer through a nationwide database...
2017: PloS One
https://www.readbyqxmd.com/read/28741200/short-and-long-term-outcomes-in-malnourished-patients-after-laparoscopic-or-open-radical-gastrectomy
#8
Hua-Long Zheng, Jun Lu, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
OBJECTIVE: The aim of this study was to compare the short- and long-term outcomes of malnourished gastric cancer patients who underwent laparoscopic or open radical gastrectomy. BACKGROUND: Preoperative malnutrition is an independent risk factor for postoperative mortality and morbidity in major gastrointestinal surgery. However, whether laparoscopic surgery can improve the short- and long-term outcomes of malnourished gastric cancer patients has not been determined...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28739709/utility-of-inflammatory-marker-and-nutritional-status-based-prognostic-factors-for-predicting-the-prognosis-of-stage-iv-gastric-cancer-patients-undergoing-non-curative-surgery
#9
Kenji Mimatsu, Nobutada Fukino, Yasuo Ogasawara, Yoko Saino, Takatsugu Oida
BACKGROUND/AIM: The present study aimed to compare the utility of various inflammatory marker- and nutritional status-based prognostic factors, including many previous established prognostic factors, for predicting the prognosis of stage IV gastric cancer patients undergoing non-curative surgery. PATIENTS AND METHODS: A total of 33 patients with stage IV gastric cancer who had undergone palliative gastrectomy and gastrojejunostomy were included in the study. Univariate and multivariate analyses were performed to evaluate the relationships between the mGPS, PNI, NLR, PLR, the CONUT, various clinicopathological factors and cancer-specific survival (CS)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28723627/evaluation-of-hepatectomy-and-palliative-local-treatments-for-gastric-cancer-patients-with-liver-metastases-a-propensity-score-matching-analysis
#10
Jiyang Li, Kecheng Zhang, Yunhe Gao, Hongqing Xi, Jianxin Cui, Wenquan Liang, Aizhen Cai, Bo Wei, Lin Chen
BACKGROUND: The optimal treatments for gastric cancer with liver metastases (GCLM) remain controversial. This study aimed to evaluate the efficacy of hepatectomy, RFA and TACE as local treatments for GCLM. METHODS: From 2001 to 2015, 119 consecutive patients who received multidisciplinary treatments based on curative gastrectomy and local treatments (hepatectomy, RFA and TACE) for liver metastases were enrolled in this retrospective cohort study. Patients were divided into Group A (46, hepatectomy) and Group B (73, either or both RFA and TACE)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28706156/time-to-local-recurrence-as-a-predictor-of-survival-in-unrecetable-gastric-cancer-patients-after-radical-gastrectomy
#11
Hui Li, Xiangyu Jin, Peng Liu, Wei Hong
Local recurrence is common after radical surgery. However, the factors that contribute to survival after local recurrence remain unclear. In this retrospective study we analyzed the relationship between time to recurrence and survival after recurrence in 74 patients with locally recurrent gastric cancer. All patients received palliative radiotherapy with or without chemotherapy. The patients were divided into two groups according to the time between gastrectomy and local recurrence: early local recurrence (ELR, < 12 months after primary surgery), and late local recurrence (LLR, ≥12 months after primary surgery)...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28705789/treatment-of-peritoneal-dissemination-in-stomach-cancer-patients-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-rationale-and-design-of-the-periscope-study
#12
Rosa T van der Kaaij, Hidde Jw Braam, Henk Boot, Maartje Los, Annemieke Cats, Cecile Grootscholten, Jan Hm Schellens, Arend Gj Aalbers, Alwin Dr Huitema, Catherijne Aj Knibbe, Djamila Boerma, Marinus J Wiezer, Bert van Ramshorst, Johanna W van Sandick
BACKGROUND: Patients with gastric cancer and peritoneal carcinomatosis have a very poor prognosis; median survival is 3 to 4 months. Palliative systemic chemotherapy is currently the only treatment available in the Netherlands. Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) has an established role in the treatment of peritoneal carcinomatosis originating from colorectal cancer, appendiceal cancer, and pseudomyxoma peritonei; its role in gastric cancer is uncertain. Currently, there is no consensus on the choice of chemotherapeutic agents used in HIPEC for gastric cancer...
July 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28685083/complete-response-to-second-line-chemotherapy-with-sunitinib-of-a-gastrointestinal-stromal-tumor-a-case-report
#13
Tsuyoshi Shirakawa, Tomoya Hirata, Kosuke Maemura, Toshiyuki Goto, Yoshiya Shimao, Kosuke Marutsuka, Yuji Ueda, Ikuo Kikuchi
Gastrointestinal stromal tumors (GISTs) are a type of sarcoma, and the most common mesenchymal tumor of the gastrointestinal tract. Systemic chemotherapy is recommended for unresectable or metastatic GISTs. Imatinib is an oral multitargeted receptor tyrosine kinase inhibitor that is effective as adjuvant chemotherapy for primary high-risk cases, and as palliative chemotherapy for unresectable or metastatic cases. For imatinib-resistant cases, second-line chemotherapy with sunitinib is recommended due to significantly longer median progression-free survival and higher response rates compared with a placebo...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28646258/selective-survival-advantage-associated-with-primary-tumor-resection-for-metastatic-gastric-cancer-in-a-western-population
#14
René Warschkow, Matthias Baechtold, Kenneth Leung, Bruno M Schmied, Daniel P Nussbaum, Beat Gloor, Dan G Blazer Iii, Mathias Worni
BACKGROUND: The prognosis of metastatic gastric cancer (GC) remains dismal, with a median survival of 10 months. Historically, primary tumor resection was not thought to confer any survival benefit. Although high-level data exist guiding treatment of metastatic GC for patients in the East, no such data exist for Western patients despite inherent ethnic differences in GC biology. METHODS: The 2006-2012 National Cancer Database was queried for adult patients with metastatic gastric adenocarcinoma...
June 23, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28625333/liver-metastases-from-gastric-carcinoma-a-case-report-and-review-of-the-literature
#15
Beata Polkowska-Pruszyńska, Karol Rawicz-Pruszyński, Bogumiła Ciseł, Robert Sitarz, Grażyna Polkowska, Witold Krupski, Wojciech P Polkowski
Gastric carcinoma (GC) is the fifth most common malignancy worldwide but the third leading cause of cancer death, and surgery remains the only curative treatment option. Prognosis of patients with liver metastases from gastric carcinoma (LMGC) is poor, and the optimal treatment of metastatic gastric cancer remains a matter of debate. In 2002, a 53-year-old male patient with GC and synchronous oligometastatic lesion in liver VIII segment underwent a total gastrectomy combined with metastasectomy. The pathologic diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), which was treated with adjuvant chemotherapy (cisplatin, epirubicin, leucovorin, and 5-fluorouracil)...
May 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28588703/decreased-expression-of-insulin-like-growth-factor-binding-protein-6-is-associated-with-gastric-adenocarcinoma-prognosis
#16
Changqing Zeng, Xingyu Feng, Wei Wang, Lin Lv, Cheng Fang, Liangjie Chi, Liangxiang Huang, Zhiwei Zhou
The present study aimed to investigate the expression and prognostic significance of insulin-like growth factor binding protein 6 (IGFBP-6) in gastric adenocarcinoma. The expression of IGFBP-6 was examined in 263 specimens from gastric adenocarcinoma patients using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blotting and immunohistochemical (IHC) staining. The association between IGFBP-6 expression, clinicopathological factors and clinical outcomes was investigated. Akaike information criterion (AIC) and Harrell's concordance index (c-index) were used to evaluate the accuracy of the predictive prognosis...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28496008/negative-lymph-node-count-is-a-significant-prognostic-factor-in-patient-with-stage-iv-gastric-cancer-after-palliative-gastrectomy
#17
Changhua Zhuo, Mingang Ying, Ruirong Lin, Xianyi Wu, Shen Guan, Chunkang Yang
Negative lymph node (NLN) count has been validated as a protective predictor in various cancers after radical resection. However, the prognostic value of NLN count in the setting of stage IV gastric cancer patients who have received palliative resection has not been investigated. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Kaplan-Meier survival curves and multivariate Cox proportional hazards model were used to assess the risk factors for patients' survivals...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28480723/extrinsic-esophageal-compression-by-the-vertebral-body
#18
Laura Santos Santamaría, Mercedes Pérez Carreras, José Díaz-Tasende, Gregorio Castellano Tortajada
A 78-year-old woman with hypertension, diabetes, dyslipidemia, and revascularized ischemic heart disease was diagnosed with gastric adenocarcinoma in 2011, with suspected bilateral adrenal metastatic disease, and was treated with subtotal gastrectomy and palliative chemotherapy. A follow-up gastroscopy in 2015 identified a protruding, erosive mid-esophageal lesion suggestive of extrinsic compression or ulcerated submucosal lesion, which had not been described previously. Follow-up was advised, and the lesion persisted after three months...
May 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28413658/subcutaneous-metastasis-arising-from-gastric-cancer-a-case-report
#19
Tsutomu Namikawa, Eri Munekage, Masaya Munekage, Hiromichi Maeda, Tomoaki Yatabe, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
A 59-year-old man was referred to the Kochi Medical School Hospital due to left shoulder pain. Physical examination revealed a nodular, painful mass lesion in the subcutaneous tissue of the right chest wall, with a diameter of ~2 cm. Esophagogastroduodenoscopy revealed a large ulcerated tumor in the lower gastric body near the lesser curvature, and biopsy specimens of the gastric and humeral lesions revealed poorly differentiated adenocarcinoma. Abdominal computed tomography revealed multiple low-density lesions in the liver and a well-defined, 2...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28360977/endoscopic-retrograde-cholangiopancretography-in-modified-double-tracks-anastomosis-with-anastomotic-stenosis
#20
Xiao-Song Wang, Fei Wang, Quan-Peng Li, Lin Miao, Xiu-Hua Zhang
A 63-year-old man presented at our hospital with right upper abdomen pain and fever for 4 d. The patient's magnetic resonance cholangiopancreatography revealed dilated common bile duct and choledocholithiasis. In his past history, he received proximal gastrectomy and modified double tracks anastomosis. Endoscopic retrograde cholangiopancretography in modified double tracks anastomosis, especially accompanied with anastomotic stenosis, has been rarely reported. In the present case, the duodenoscope was successfully introduced over the guidewire and the stone taken out using a basket...
March 16, 2017: World Journal of Gastrointestinal Endoscopy
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