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https://www.readbyqxmd.com/read/28337334/correction-to-chiral-cyclohexane-1-3-diones-as-inhibitors-of-mutant-sod1-dependent-protein-aggregation-for-the-treatment-of-als
#1
Yinan Zhang, Radhia Benmohamed, Wei Zhang, Jinho Kim, Christina K Edgerly, Yaoqiu Zhu, Richard I Morimoto, Robert J Ferrante, Donald R Kirsch, Richard B Silverman
[This corrects the article DOI: 10.1021/ml3000963.].
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28317979/fluorescent-bioimaging-of-ph-from-design-to-applications
#2
Ji-Ting Hou, Wen Xiu Ren, Kun Li, Jinho Seo, Amit Sharma, Xiao-Qi Yu, Jong Seung Kim
Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable...
March 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28290161/corticosteroids-for-tuberculous-pleurisy
#3
REVIEW
Hannah Ryan, Jinho Yoo, Padmapriya Darsini
BACKGROUND: Corticosteroids used in addition to antituberculous therapy have been reported to benefit people with tuberculous pleurisy. However, research findings are inconsistent and raise doubt as to whether such treatment is worthwhile. There is also concern regarding the potential adverse effects of corticosteroids, especially in HIV-positive people. OBJECTIVES: To evaluate the effects of adding corticosteroids to drug regimens for tuberculous pleural effusion...
March 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28282797/relief-of-knee-flexion-contracture-and-gait-improvement-following-adaptive-training-for-an-assist-device-in-a-transtibial-amputee-a-case-study
#4
Sol-Bi Kim, Chang-Yong Ko, Jinho Son, Sungjae Kang, Jeicheong Ryu, Museong Mun
BACKGROUND: Management of a knee contracture is important for regaining gait ability in transtibial amputees. However, there has been little study of prosthesis training for enhancing mobility and improving range of motion in cases of restricted knee extension. OBJECTIVE: This study aimed to evaluate the effects of adaptive training for an assist device (ATAD) for a transtibial amputee with a knee flexion contracture (KFC). A male transtibial amputee with KFC performed 4 months of ATAD with a multidisciplinary team...
2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28278133/flat-panel-shaped-hybrid-piezo-triboelectric-nanogenerator-for-ambient-energy-harvesting
#5
Gul Hassan, Fasihullah Khan, Arshad Hassan, Shawkat Ali, Jinho Bae, Chong Hyun Lee
Recently, many researchers are paying attention to nanogenerators (NGs) as energy source in self-powered mirco-nano system, and studying how to achieve their higher power generation. Hence, we propose a hybrid type NG harvesting both piezoelectric and triboelectric effect at the same time. In the proposed hybrid NG, the piezoelectric NG (PNG) and triboelectric NG (TENG) are fabricated by Polydimethylsiloxane (PDMS) and perovskite Zinc stannite (ZnSnO<sub>3</sub>) nano cubes with a high charge polarization of 59 uC/cm<sup>2</sup> composite (PDMS+ZnSnO<sub>3</sub>) and UV surface treated PDMS, respectively...
March 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28266665/a-self-assembled-ni-cyclam-btc-network-on-ito-for-an-oxygen-evolution-catalyst-in-alkaline-solution
#6
Yun Jin Leem, Keumnam Cho, Kyung Hee Oh, Sung-Hwan Han, Ki Min Nam, Jinho Chang
A self-assembled Ni(cyclam)-BTC film was formed on ITO in an acidic solution. Ni(cyclam)-BTC exhibited an enhanced electro-catalytic property for the oxygen evolution reaction (OER), which was strongly relevant to the Ni(iii)/Ni(iv) redox reaction activated by the potential dynamic process. A possible formation mechanism of Ni(cyclam)-BTC by self-assembly on ITO was also proposed.
March 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28155879/synergistic-effect-of-indium-and-gallium-co-doping-on-growth-behavior-and-physical-properties-of-hydrothermally-grown-zno-nanorods
#7
Jun Hyung Lim, Seung Muk Lee, Hyun-Suk Kim, Hyun You Kim, Jozeph Park, Seung-Boo Jung, Geun Chul Park, Jungho Kim, Jinho Joo
We synthesized ZnO nanorods (NRs) using simple hydrothermal method, with the simultaneous incorporation of gallium (Ga) and indium (In), in addition, investigated the co-doping effect on the morphology, microstructure, electronic structure, and electrical/optical properties. The growth behavior of the doped NRs was affected by the nuclei density and polarity of the (001) plane. The c-axis parameter of the co-doped NRs was similar to that of undoped NRs due to the compensated lattice distortion caused by the presence of dopants that are both larger (In(3+)) and smaller (Ga(3+)) than the host Zn(2+) cations...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129399/long-term-course-of-failed-back-surgery-syndrome-fbss-patients-receiving-integrative-korean-medicine-treatment-a-1-year-prospective-observational-multicenter-study
#8
Jinho Lee, Joon-Shik Shin, Yoon Jae Lee, Me-Riong Kim, Areum Choi, Jun-Hwan Lee, Kyung-Min Shin, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha
BACKGROUND: With increase of spine surgeries, failed back surgery syndrome (FBSS) prevalence is also rising. While complementary and alternative medicine (CAM) is commonly used for low back pain (LBP), there are no studies reporting use of integrative Korean medicine in FBSS patients. METHODS: Patients with pain continuing after back surgery or recurring within 1 year and visual analogue scale (VAS) of LBP or leg pain of ≥6 (total n = 120) were recruited at 2 hospital sites from November 2011 to September 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28106392/anti-osteoporotic-activity-of-harpagoside-by-upregulation-of-the-bmp2-and-wnt-signaling-pathways-in-osteoblasts-and-suppression-of-differentiation-in-osteoclasts
#9
Hwa-Jin Chung, Won Kyung Kim, Jedo Oh, Me-Riong Kim, Joon-Shik Shin, Jinho Lee, In-Hyuk Ha, Sang Kook Lee
Harpagoside (1) is an iridoid glycoside isolated from the radix of Harpagophytum procumbens var. sublobatum, commonly called Devil's claw. The anti-osteoporotic effect of 1 was investigated in both in vitro cell cultures and in vivo using an ovariectomized (OVX) mouse model. Compound 1 induced bone formation by stimulating osteoblast proliferation, alkaline phosphatase activity, and mineralization in osteoblastic MC3T3-E1 cells. Treatment with 1 increased the mRNA and protein expression of bone formation biomarkers through regulation of the BMP2 and Wnt signaling pathway in MC3T3-E1 cells...
February 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28078368/time-dependent-toxicity-responses-in-daphnia-magna-exposed-to-cuo-and-zno-nanoparticles
#10
Soyoun Kim, Palas Samanta, Jisu Yoo, Woo-Keun Kim, Jinho Jung
Aggregation and dissolution of CuO and ZnO nanoparticles (NPs) increased with increasing exposure time (24, 48, and 72 h). Acute toxicity of CuO NPs to Daphnia magna also increased significantly with increasing exposure time (p < 0.05), whereas exposure time did not significantly affect acute toxicity of ZnO NPs. The dissolved Cu concentration of CuO NPs was much lower than the median effective concentration (EC50) value (44 μg L(-1) at 72 h), implying that the increase in acute toxicity was caused by particles rather than by dissolved ions...
April 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28059128/c-terminus-of-hsc70-interacting-protein-chip-inhibits-adipocyte-differentiation-via-ubiquitin-and-proteasome-mediated-degradation-of-ppar%C3%AE
#11
Jung-Hoon Kim, Soyeon Shin, Jinho Seo, Eun-Woo Lee, Manhyung Jeong, Min-Sik Lee, Hyun-Ji Han, Jaewhan Song
PPARγ (Peroxisome proliferator-activated receptor γ) is a nuclear receptor involved in lipid homeostasis and related metabolic diseases. Acting as a transcription factor, PPARγ is a master regulator for adipocyte differentiation. Here, we reveal that CHIP (C-terminus of HSC70-interacting protein) suppresses adipocyte differentiation by functioning as an E3 ligase of PPARγ. CHIP directly binds to and induces ubiquitylation of the PPARγ protein, leading to proteasome-dependent degradation. Stable overexpression or knockdown of CHIP inhibited or promoted adipogenesis, respectively, in 3T3-L1 cells...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056846/biological-age-as-a-useful-index-to-predict-seventeen-year-survival-and-mortality-in-koreans
#12
Jinho Yoo, Yangseok Kim, Eo Rin Cho, Sun Ha Jee
BACKGROUND: Many studies have been conducted to quantitatively estimate biological age using measurable biomarkers. Biological age should function as a valid proxy for aging, which is closely related with future work ability, frailty, physical fitness, and/or mortality. A validation study using cohort data found biological age to be a superior index for disease-related mortality than chronological age. The purpose of this study is to demonstrate the validity of biological age as a useful index to predict a person's risk of death in the future...
January 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28052880/impact-of-visit-to-visit-variability-in-systolic-blood-pressure-on-cardiovascular-outcomes-in-korean-national-health-insurance-service-national-sample-cohort
#13
SeongIl Choi, Jinho Shin, Sung Yong Choi, Ki Chul Sung, Sang Hyun Ihm, Kwang-Il Kim, Yu-Mi Kim
BACKGROUND: Despite an association between visit-to-visit blood pressure (BP) variability (VV-BPV) and cardiovascular (CV) outcomes, many studies performed during the past 4 years have shown conflicting results. This study investigated the impact of VV-BPV on CV outcomes in the Korean National Health Insurance Service (NHIS) database-National Sample Cohort. METHODS: From the 2002 Korean NHIS database (n = 47,851,928), sample subjects with 3 or more BP measurements (n = 51,811) were divided into 2 groups according to a 10 mm Hg cutoff in the SD of systolic BP (SD-SBP)...
January 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28035833/correction-to-cu-catalyzed-aerobic-oxidation-of-di-tert-butyl-hydrazodicarboxylate-to-di-tert-butyl-azodicarboxylate-and-its-application-on-dehydrogenation-of-1-2-3-4-tetrahydroquinolines-under-mild-conditions
#14
https://www.readbyqxmd.com/read/28025981/brake-and-gas-pedals-in-motor-cortex
#15
Jinho Kim, S Andrew Hires
No abstract text is available yet for this article.
December 27, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/28024536/nanocellulose-based-asymmetric-composite-membrane-for-the-multiple-functions-in-cell-encapsulation
#16
Minsung Park, Sungchul Shin, Jie Cheng, Jinho Hyun
We describe the nanocomposite membrane for cell encapsulation using nanocelluose hydrogels. One of the surfaces of bacterial cellulose (BC) pellicles was coated with collagen to enhance cell adhesion and the opposite side of the BC pellicles was coated with alginate to protect transplanted cells from immune rejection by the reduced pore size of the composite membrane. The morphology of nanocomposite membrane was observed by scanning electron microscopy and the permeability of the membrane was estimated by the release test using different molecular weights of polymer solution...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27978631/cu-catalyzed-aerobic-oxidation-of-di-tert-butyl-hydrazodicarboxylate-to-di-tert-butyl-azodicarboxylate-and-its-application-on-dehydrogenation-of-1-2-3-4-tetrahydroquinolines-under-mild-conditions
#17
Dahyeon Jung, Min Hye Kim, Jinho Kim
A new class of co-catalytic system was developed with homogeneous CuI and di-tert-butyl azodicarboxylate for aerobic dehydrogenation of 1,2,3,4-tetrahydroquinolines under mild conditions. The developed co-catalytic system is consisting of di-tert-butyl azodicarboxylate-mediated dehydrogenation of 1,2,3,4-tetrahydroquinoline and aerobic oxidative regeneration of di-tert-butyl azodicarboxylate from di-tert-butyl hydrazodicarboxylate using molecular oxygen as a terminal oxidant. A variety of quinolines were efficiently synthesized by the developed Cu and di-tert-butyl azodicarboxylate co-catalytic system...
December 16, 2016: Organic Letters
https://www.readbyqxmd.com/read/27955988/electrochemical-h2o2-biosensor-composed-of-myoglobin-on-mos2-nanoparticle-graphene-oxide-hybrid-structure
#18
Jinho Yoon, Taek Lee, Bharate Bapurao G, Jinhee Jo, Byung-Keun Oh, Jeong-Woo Choi
In this research, the electrochemical biosensor composed of myoglobin (Mb) on molybdenum disulfide nanoparticles (MoS2 NP) encapsulated with graphene oxide (GO) was fabricated for the detection of hydrogen peroxide (H2O2). Hybrid structure composed of MoS2 NP and GO (GO@MoS2) was fabricated for the first time to enhance the electrochemical signal of the biosensor. As a sensing material, Mb was introduced to fabricate the biosensor for H2O2 detection. Formation and immobilization of GO@MoS2 was confirmed by transmission electron microscopy, ultraviolet-visible spectroscopy, scanning electron microscopy, and scanning tunneling microscopy...
July 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27930719/in-vitro-and-in-vivo-anti-allergic-and-anti-inflammatory-effects-of-ebv-a-newly-developed-derivative-of-bee-venom-through-modulation-of-irf3-signaling-pathway-in-a-carrageenan-induced-edema-model
#19
Hwa-Jin Chung, Jinho Lee, Joon-Shik Shin, Me-Riong Kim, Wonil Koh, Min-Jeong Kim, Jae-Woong Lee, Eun Jee Kim, In-Hee Lee, Won Kyung Kim, Yoon Jae Lee, Sang Kook Lee, In-Hyuk Ha
BACKGROUND: Bee venom (BV), a type of toxin extracted from honeybees (Apis mellifera), has been empirically and widely used to treat inflammatory diseases throughout Asia. Essential BV (eBV) was developed by removing phospholipase A2 (PLA2) and histamine to lower occurrence of allergic reaction. This study investigated the anti-allergic and anti-inflammatory activities of eBV in vitro and in vivo and its underlying mechanism of action. METHODS: The anti-inflammatory potential of eBV was assessed in vivo using a carrageenan-induced paw edema model...
2016: PloS One
https://www.readbyqxmd.com/read/27885700/heterogeneous-monolithic-integration-of-single-crystal-organic-materials
#20
Kyung Sun Park, Jangmi Baek, Yoonkyung Park, Lynn Lee, Jinho Hyon, Yong-Eun Koo Lee, Nabeen K Shrestha, Youngjong Kang, Myung Mo Sung
Manufacturing high-performance organic electronic circuits requires the effective heterogeneous integration of different nanoscale organic materials with uniform morphology and high crystallinity in a desired arrangement. In particular, the development of high-performance organic electronic and optoelectronic devices relies on high-quality single crystals that show optimal intrinsic charge-transport properties and electrical performance. Moreover, the heterogeneous integration of organic materials on a single substrate in a monolithic way is highly demanded for the production of fundamental organic electronic components as well as complex integrated circuits...
November 25, 2016: Advanced Materials
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