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https://www.readbyqxmd.com/read/29205494/acral-accentuated-exanthem-in-an-infant-with-parechovirus-meningitis
#1
Dawn Lee, Sin Wee Loh, Juliet Tan, Jinho Chong
We report a case of an infant who had presented with fever and an acral-accentuated rash, for which his cerebrospinal fluid returned positive for parechovirus. He was treated symptomatically and discharged well, with no long-term complications.
December 4, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29186040/silver-nanoparticle-modified-electrode-covered-by-graphene-oxide-for-the-enhanced-electrochemical-detection-of-dopamine
#2
Jae-Wook Shin, Kyeong-Jun Kim, Jinho Yoon, Jinhee Jo, Waleed Ahmed El-Said, Jeong-Woo Choi
Several neurological disorders such as Alzheimer's disease and Parkinson's disease have become a serious impediment to aging people nowadays. One of the efficient methods used to monitor these neurological disorders is the detection of neurotransmitters such as dopamine. Metal materials, such as gold and platinum, are widely used in this electrochemical detection method; however, low sensitivity and linearity at low dopamine concentrations limit the use of these materials. To overcome these limitations, a silver nanoparticle (SNP) modified electrode covered by graphene oxide for the detection of dopamine was newly developed in this study...
November 29, 2017: Sensors
https://www.readbyqxmd.com/read/29161804/importance-of-biological-ultrafine-particles-in-indoor-dust-as-a-pathogenesis-of-chronic-inflammatory-lung-diseases
#3
Young-Koo Jee, Jinho Yang, Yoon-Keun Kim, You-Young Kim, Tae Soo Kang
The role of infectious agents in the etiology of inflammatory diseases once believed to be non-infectious is increasingly being recognized. Many bacterial components in the indoor dust can evoke inflammatory lung diseases. Bacteria secrete nanometer-sized vesicles into the extracellular milieu, so-called extracellular vesicles (EVs). which are pathophysiologically related to inflammatory diseases. Microbiota compositions in the indoor dust revealed the presence of both gram-negative and gram-positive bacteria...
November 17, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29157127/modulation-of-the-gut-microbiota-by-metformin-improves-metabolic-profiles-in-aged-obese-mice
#4
Heetae Lee, Youngjoo Lee, Jiyeon Kim, Jinho An, Sungwon Lee, Hyunseok Kong, Youngcheon Song, Chong-Kil Lee, Kyungjae Kim
The gut microbiota is a contributing factor in obesity-related metabolic disorders. The effect of metformin on the gut microbiota has been reported; however, the relationship between the gut microbiota and the mechanism of action of metformin in elderly individuals is unclear. In this study, the effect of metformin on the gut microbiota was investigated in aged obese mice. The abundance of the genera Akkermansia, Bacteroides, Butyricimonas, and Parabacteroides was significantly increased by metformin in mice fed a high-fat diet...
November 20, 2017: Gut Microbes
https://www.readbyqxmd.com/read/29145327/current-practice-and-usual-care-of-major-cervical-disorders-in-korea-a-cross-sectional-study-of-korean-health-insurance-review-and-assessment-service-national-patient-sample-data
#5
A Ryeon Choi, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Min-Seok Oh, Eun-Jung Lee, Sungchul Kim, Mia Kim, In-Hyuk Ha
Neck pain is a highly common condition and is the 4th major cause of years lived with disability. Previous literature has focused on the effect of specific treatments, and observations of actual practice are lacking to date. This study examined Korean health insurance review and assessment service (HIRA) claims data to the aim of assessing prevalence and comparing current medical practice and costs of cervical disorders in Korea.Current practice trends were determined through assessment of prevalence, total expenses, per-patient expense, average days in care, average days of visits, sociodemographic characteristics, distribution of medical costs, and frequency of treatment types of high frequency cervical disorders (cervical sprain/strain, cervical intervertebral disc displacement [IDD], and cervicalgia)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29126382/analysis-of-medical-service-use-of-knee-osteoarthritis-and-knee-meniscal-and-ligament-injuries-in-korea-a-cross-sectional-study-of-national-patient-sample-data
#6
Chang Yong Suh, Yoon Jae Lee, Joon-Shik Shin, Jinho Lee, Me-Riong Kim, Wonil Koh, Yun-Yeop Cha, Byung-Cheul Shin, Eui-Hyoung Hwang, Kristin Suhr, Mia Kim, In-Hyuk Ha
BACKGROUND: Osteoarthritis (OA) and meniscal and ligament injuries of the knee are the two most common knee disorders in Korea. The aim of this study was to analyze the demographic characteristics, medical service use and related costs for these disorders, and the results are expected to help inform practitioners, researchers, and policy-makers. METHODS: The present study aimed to evaluate incidence and patient characteristics, and to assess current medical service use, usual care, and medical expenses of knee disorders by analyzing 2014 national patient sample data from the Korean Health Insurance Review and Assessment Service...
November 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29121797/effectiveness-of-acupuncture-and-electroacupuncture-for-chronic-neck-pain-a-systematic-review-and-meta-analysis
#7
See Yoon Seo, Ki-Beom Lee, Joon-Shik Shin, Jinho Lee, Me-Riong Kim, In-Hyuk Ha, Youme Ko, Yoon Jae Lee
The aim of this systematic review was to assess evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture and electroacupuncture in patients with chronic neck pain. We searched nine databases including Chinese, Japanese and Korean databases through 30 July 2016. The participants were adults with chronic neck pain and were treated with acupuncture or electroacupuncture. Eligible trials were those with intervention groups receiving acupuncture and electroacupuncture with or without active control, and control groups receiving other conventional treatments such as physical therapy or medication...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29115094/the-first-successful-lung-transplantation-in-a-korean-child-with-cystic-fibrosis
#8
Soo Ran Noh, Eun Lee, Jisun Yoon, Sungsu Jung, Song I Yang, Jinho Yu, Soo Jong Hong
Cystic fibrosis (CF) is an autosomal recessive inherited multisystem disorder caused by mutations of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Respiratory failure remains the most frequent cause of morbidity and mortality. Lung transplantation is the only option to treat end-stage lung disease. Very few cases of CF occur in Koreans. We report the case of a 12-year-old girl with respiratory failure due to CF who underwent lung transplantation. She had been diagnosed with CF 8 years previously after being treated for recurrent Pseudomonas aeruginosa pneumonia and malnutrition based on sweat chloride concentrations and the CFTR protein gene mutation test...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29111150/small-molecule-delivery-to-solid-tumors-with-chitosan-coated-plga-particles-a-lesson-learned-from-comparative-imaging
#9
Jinho Park, Yihua Pei, Hyesun Hyun, Mark A Castanares, David S Collins, Yoon Yeo
For polymeric nanoparticles (NPs) to deliver more drugs to tumors than free drug solution, it is critical that the NPs establish interactions with tumor cells and avoid removal from the tumors. Since traditional polyethylene glycol (PEG) surface layer interferes with the cell-NP interaction in tumors, we used a water-soluble and blood-compatible chitosan derivative called zwitterionic chitosan (ZWC) as an alternative surface coating for poly(lactic-co-glycolic acid) (PLGA) NPs. The ZWC-coated PLGA NPs showed pH-dependent surface charge profiles and differential cellular interactions according to the pH of the medium...
October 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29103263/hematological-changes-associated-with-theileria-orientalis-infection-in-korean-indigenous-cattle
#10
Suhee Kim, Do-Hyeon Yu, Sung-Woo Kang, Jeong-Byoung Chae, Kyoung-Seong Choi, Hyeon-Cheol Kim, Bae-Keun Park, Joon-Seok Chae, Jinho Park
Tick-borne pathogens can cause serious problems in grazing cattle. However, little information is available on tick-mediated diseases in cattle grazing on mountains. Thus, this study aimed to understand the potential problems related to tick-borne diseases in grazing cattle through the investigation of prevalent tick-transmitted infections, and their associated hematological changes, in terms of season and grazing type in Korean indigenous cattle (=Hanwoo). Hanwoo cattle from 3 regions of the Republic of Korea (=Korea) were either maintained indoors or placed on grassy mountains from spring to fall of 2014 and 2015...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29100180/ecological-risk-assessment-of-a-contaminated-stream-using-multi-level-integrated-biomarker-response-in-carassius-auratus
#11
Palas Samanta, Hyungjoon Im, Joorim Na, Jinho Jung
The goal of this study was to evaluate the adverse effects of wastewater effluents on freshwater crucian carp, Carassius auratus, inhabiting Sincheon stream using the integrated biomarker response (IBR) at the genotoxic (micronucleus [MN] test), oxidative stress (activity of catalase [CAT] and glutathione S-transferase [GST], and level of lipid peroxidation [LPO]), histopathological (degree of tissue changes [DTC]), and physiological (condition factor [CF] and liver somatic index [LSI]) levels. The CF and LSI were significantly (p < 0...
October 31, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29094741/a-disposable-microfluidic-device-with-a-reusable-magnetophoretic-functional-substrate-for-isolation-of-circulating-tumor-cells
#12
Hyungseok Cho, Jinho Kim, Chang-Wan Jeon, Ki-Ho Han
We describe an assembly-disposable microfluidic device based on a silicone-coated release polymer thin film. It consists of a disposable polymeric superstrate and a reusable functional substrate and they are assembled simply using vacuum pressure. The disposable polymeric superstrate is manufactured by bonding a silicone-coated release polymer thin film and a microstructured polydimethylsiloxane (PDMS) replica, containing only a simple structured microchannel. The reusable functional substrate generates an intricate energy field that can penetrate the micrometer-thick polymer film into the microchannel and control microfluids...
November 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29093639/rapid-assessment-of-microbiota-changes-in-individuals-with-autism-spectrum-disorder-using-bacteria-derived-membrane-vesicles-in-urine
#13
Yunjin Lee, Jin-Young Park, Eun-Hwa Lee, Jinho Yang, Bo-Ri Jeong, Yoon-Keun Kim, Ju-Young Seoh, SoHyun Lee, Pyung-Lim Han, Eui-Jung Kim
Individuals with autism spectrum disorder (ASD) have altered gut microbiota, which appears to regulate ASD symptoms via gut microbiota-brain interactions. Rapid assessment of gut microbiota profiles in ASD individuals in varying physiological contexts is important to understanding the role of the microbiota in regulating ASD symptoms. Microbiomes secrete extracellular membrane vesicles (EVs) to communicate with host cells and secreted EVs are widely distributed throughout the body including the blood and urine...
October 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29079844/genetic-and-phenotypic-characterization-of-the-novel-mouse-substrain-c57bl-6n-korl-with-increased-body-weight
#14
Kyung-Min Choi, Jaehoon Jung, Young Min Cho, Kwondo Kim, Mi-Gyeong Kim, Jinho Kim, Huibae Kim, Hee Jung Shin, Hae Deun Kim, Seung-Tae Chung, Seoae Cho, Myeon-Woo Chung
In inbred mouse lines, there is generally little genetic difference between individuals. This small genetic variability facilitates carrying out research on minute changes of various traits and the gene pool. Also, characterizing the diversity and detecting selective genetic and phenotypic signatures are crucial to understanding the genomic basis of a population and to identify specific patterns of evolutionary change. In this study, we investigated the underlying genetic profiles of a newly developed mouse strain, C57BL/6NKorl (Korl), established through sibling mating over 30 generations...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29055285/delayed-spontaneous-resorption-of-lumbar-intervertebral-disc-herniation-a-case-report
#15
You Jin Jung, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, In-Hyuk Ha
Background • Large intervertebral disc herniation is often managed with surgery, but it is not uncommon for spontaneous resorption of herniated disc material to occur. Although the majority of spontaneous disc resorption occurs in the acute phase, an unusual case of delayed intervertebral disc regression at 18 mo postonset is presented. Case Presentation • A 32-y-old female patient presented with acute low-back pain and pain in both legs a Korean medicine hospital specializing in spinal disorders. Massive intervertebral disc herniation was found on lumbar magnetic resonance imaging (MRI), and inguinal and genital pain and numbness was suggestive of risk of cauda equina syndrome...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29053682/implantation-of-chronic-silicon-probes-and-recording-of-hippocampal-place-cells-in-an-enriched-treadmill-apparatus
#16
Anvar Sariev, Jinho Chung, Dajung Jung, Farnaz Sharif, Ju-Young Lee, Soyoun Kim, Sebastien Royer
An important requisite for understanding brain function is the identification of behavior and cell activity correlates. Silicon probes are advanced electrodes for large-scale electrophysiological recording of neuronal activity, but the procedures for their chronic implantation are still underdeveloped. The activity of hippocampal place cells is known to correlate with an animal's position in the environment, but the underlying mechanisms are still unclear. To investigate place cells, here we describe a set of techniques which range from the fabrication of devices for chronic silicon probe implants to the monitoring of place field activity in a cue-enriched treadmill apparatus...
October 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29032097/comparative-assessment-of-the-adverse-outcome-of-wastewater-effluents-by-integrating-oxidative-stress-and-histopathological-alterations-in-endemic-fish
#17
Palas Samanta, Hyungjoon Im, Jisu Yoo, Hwanggoo Lee, Nan-Young Kim, Wonky Kim, Soon-Jin Hwang, Woo-Keun Kim, Jinho Jung
This study evaluated the adverse effect of wastewater effluents on three fish species, Carassius auratus, Zacco platypus, and Zacco koreanus, collected in the Eungcheon, Mihocheon, and Busocheon streams, respectively. Fish gills, liver, and kidneys from the mixing zone (MZ) and sites upstream (US) and downstream (DS) of the MZ were analyzed for oxidative stress responses and histology. Catalase and glutathione S-transferase activity was significantly higher at MZ and DS than from US (p<0.05), indicating induction of antioxidant defense mechanisms...
October 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29026127/controlled-delivery-and-minimally-invasive-imaging-of-stem-cells-in-the-lung
#18
Jinho Kim, Brandon Guenthart, John D O'Neill, N Valerio Dorrello, Matthew Bacchetta, Gordana Vunjak-Novakovic
Intratracheal delivery of stem cells into injured or diseased lungs can provide a variety of therapeutic and immunomodulatory effects for the treatment of acute lung injury and chronic lung disease. While the efficacy of this approach depends on delivering the proper cell dosage into the target region of the airway, tracking and analysis of the cells have been challenging, largely due to the limited understanding of cell transport and lack of suitable cell monitoring techniques. We report on the transport and deposition of intratracheally delivered stem cells as well as strategies to modulate the number of cells (e...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992674/is-helicobacter-pylori-associated-functional-dyspepsia-correlated-with-dysbiosis
#19
REVIEW
Yeon-Ji Kim, Woo Chul Chung, Byung Wook Kim, Sung Soo Kim, Jin Il Kim, Na Jin Kim, Jinho Yoo, Soo Hwan Kim
Background/Aims: To assess the long-term effect of Helicobacter pylori eradication on symptomatic improvement according to the type of antibiotic and the duration of treatment in H. pylori-associated functional dyspepsia. Methods: We searched Pubmed, Embase, CINAHL, and the Cochrane library databases for randomized controlled trials written in English and undertaken up to August 2016 that met our eligibility criteria. The search methodology used combinations of the following keywords: Helicobacter pylori OR H...
October 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28963874/predictors-of-longitudinal-aba-treatment-outcomes-for-children-with-autism-a-growth-curve-analysis
#20
Michael Tiura, Jinho Kim, Deanne Detmers, Hilary Baldi
BACKGROUND: Autism spectrum disorder (ASD) is a developmental disorder that causes lifelong disability. Applied Behavior Analysis (ABA) is one of the most empirically studied and validated approaches for treating children diagnosed with ASD. Due to the heterogeneity of ASD, it is important to ascertain who will most benefit from treatment. METHODS: In this study, 35 participants, with a mean entry age of 3 years, received ABA therapy. Children were assessed at intake and every 6 months thereafter using the Developmental Profile-3 (DP-3) to measure their communication, social-emotional, adaptive behavior, and physical development (2-6 measures per participant)...
September 27, 2017: Research in Developmental Disabilities
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