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https://www.readbyqxmd.com/read/29055285/delayed-spontaneous-resorption-of-lumbar-intervertebral-disc-herniation-a-case-report
#1
You Jin Jung, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, In-Hyuk Ha
Background • Large intervertebral disc herniation is often managed with surgery, but it is not uncommon for spontaneous resorption of herniated disc material to occur. Although the majority of spontaneous disc resorption occurs in the acute phase, an unusual case of delayed intervertebral disc regression at 18 mo postonset is presented. Case Presentation • A 32-y-old female patient presented with acute low-back pain and pain in both legs a Korean medicine hospital specializing in spinal disorders. Massive intervertebral disc herniation was found on lumbar magnetic resonance imaging (MRI), and inguinal and genital pain and numbness was suggestive of risk of cauda equina syndrome...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29053682/implantation-of-chronic-silicon-probes-and-recording-of-hippocampal-place-cells-in-an-enriched-treadmill-apparatus
#2
Anvar Sariev, Jinho Chung, Dajung Jung, Farnaz Sharif, Ju-Young Lee, Soyoun Kim, Sebastien Royer
An important requisite for understanding brain function is the identification of behavior and cell activity correlates. Silicon probes are advanced electrodes for large-scale electrophysiological recording of neuronal activity, but the procedures for their chronic implantation are still underdeveloped. The activity of hippocampal place cells is known to correlate with an animal's position in the environment, but the underlying mechanisms are still unclear. To investigate place cells, here we describe a set of techniques which range from the fabrication of devices for chronic silicon probe implants to the monitoring of place field activity in a cue-enriched treadmill apparatus...
October 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29032097/comparative-assessment-of-the-adverse-outcome-of-wastewater-effluents-by-integrating-oxidative-stress-and-histopathological-alterations-in-endemic-fish
#3
Palas Samanta, Hyungjoon Im, Jisu Yoo, Hwanggoo Lee, Nan-Young Kim, Wonky Kim, Soon-Jin Hwang, Woo-Keun Kim, Jinho Jung
This study evaluated the adverse effect of wastewater effluents on three fish species, Carassius auratus, Zacco platypus, and Zacco koreanus, collected in the Eungcheon, Mihocheon, and Busocheon streams, respectively. Fish gills, liver, and kidneys from the mixing zone (MZ) and sites upstream (US) and downstream (DS) of the MZ were analyzed for oxidative stress responses and histology. Catalase and glutathione S-transferase activity was significantly higher at MZ and DS than from US (p<0.05), indicating induction of antioxidant defense mechanisms...
October 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29026127/controlled-delivery-and-minimally-invasive-imaging-of-stem-cells-in-the-lung
#4
Jinho Kim, Brandon Guenthart, John D O'Neill, N Valerio Dorrello, Matthew Bacchetta, Gordana Vunjak-Novakovic
Intratracheal delivery of stem cells into injured or diseased lungs can provide a variety of therapeutic and immunomodulatory effects for the treatment of acute lung injury and chronic lung disease. While the efficacy of this approach depends on delivering the proper cell dosage into the target region of the airway, tracking and analysis of the cells have been challenging, largely due to the limited understanding of cell transport and lack of suitable cell monitoring techniques. We report on the transport and deposition of intratracheally delivered stem cells as well as strategies to modulate the number of cells (e...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992674/is-helicobacter-pylori-associated-functional-dyspepsia-correlated-with-dysbiosis
#5
REVIEW
Yeon-Ji Kim, Woo Chul Chung, Byung Wook Kim, Sung Soo Kim, Jin Il Kim, Na Jin Kim, Jinho Yoo, Soo Hwan Kim
Background/Aims: To assess the long-term effect of Helicobacter pylori eradication on symptomatic improvement according to the type of antibiotic and the duration of treatment in H. pylori-associated functional dyspepsia. Methods: We searched Pubmed, Embase, CINAHL, and the Cochrane library databases for randomized controlled trials written in English and undertaken up to August 2016 that met our eligibility criteria. The search methodology used combinations of the following keywords: Helicobacter pylori OR H...
October 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28963874/predictors-of-longitudinal-aba-treatment-outcomes-for-children-with-autism-a-growth-curve-analysis
#6
Michael Tiura, Jinho Kim, Deanne Detmers, Hilary Baldi
BACKGROUND: Autism spectrum disorder (ASD) is a developmental disorder that causes lifelong disability. Applied Behavior Analysis (ABA) is one of the most empirically studied and validated approaches for treating children diagnosed with ASD. Due to the heterogeneity of ASD, it is important to ascertain who will most benefit from treatment. METHODS: In this study, 35 participants, with a mean entry age of 3 years, received ABA therapy. Children were assessed at intake and every 6 months thereafter using the Developmental Profile-3 (DP-3) to measure their communication, social-emotional, adaptive behavior, and physical development (2-6 measures per participant)...
September 27, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28953247/anti-adipogenic-effects-on-3t3-l1-cells-and-zebrafish-by-tanshinone-iia
#7
Yu-Kyoung Park, Brice Wilfried Obiang-Obounou, Jinho Lee, Tae-Yun Lee, Myung-Ae Bae, Kyu-Seok Hwang, Kyung-Bok Lee, Jong-Soon Choi, Byeong-Churl Jang
Tanshinone IIA is a diterpene quinone isolated from the roots of Salviamiltiorrhiza bunge that has traditionally been used in China for the treatment of cardiovascular and cerebrovascular disorders. Although there is recent evidence showing that tanshinone IIA has an anti-obesity effect, its underlying mechanism of anti-obesity effect is poorly understood. Here, we investigated the effect of tanshinone IIA on lipid accumulation in 3T3-L1 preadipocytes and zebrafish. Notably, tanshinone IIA at 10 μM concentration greatly reduced lipid accumulation and triglyceride (TG) contents during 3T3-L1 preadipocyte differentiation, suggesting its anti-adipogenic effect...
September 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28952735/strong-proximity-josephson-coupling-in-vertically-stacked-nbse2-graphene-nbse2-van-der-waals-junctions
#8
Minsoo Kim, Geon-Hyoung Park, Jongyun Lee, Jae Hyeong Lee, Jinho Park, Hyunwoo Lee, Gil-Ho Lee, Hu-Jong Lee
A layered two-dimensional superconducting material 2H-NbSe2 is used to build a van der Waals heterostructure, where a proximity-coupled superconducting order can be induced in the interfacing materials. Vertically stacked NbSe2-graphene-NbSe2 is fabricated using van der Waals interlayer coupling, producing defect-free contacts with a high interfacial transparency. The atomically thin graphene layer allows the formation of a highly coherent proximity Josephson coupling between the two NbSe2 flakes. The temperature dependence of the junction critical current (Ic) reveals short and ballistic Josephson coupling characteristics that agree with theoretical prediction...
October 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28939741/tumor-heterogeneity-predicts-metastatic-potential-in-colorectal-cancer
#9
Je-Gun Joung, Bo Young Oh, Hye Kyung Hong, Hisham AlKhalidi, Faisal Al-Alem, Hae-Ock Lee, Joon Seol Bae, Jinho Kim, Hong-Ui Cha, Maram Alotaibi, Yong Beom Cho, Mazen Hassanain, Woo Yong Lee, Woong-Yang Park
PURPOSE: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer (CRC) tumor samples to determine whether tumor heterogeneity can predict tumor metastasis. EXPERIMENTAL DESIGN: Somatic variations in 46 pairs of matched primary-liver metastatic tumors and 42 primary tumors without metastasis were analyzed by whole exome sequencing...
September 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28928789/the-long-term-course-of-outcomes-for-lumbar-intervertebral-disc-herniation-following-integrated-complementary-and-alternative-medicine-inpatient-treatment-a-prospective-observational-study
#10
Moon-Hwi Kim, Yoon Jae Lee, Joon-Shik Shin, Jinho Lee, Haechan Jeong, Me-Riong Kim, Sam-Min Park, Ung Go, Sung-Moon Kim, Jae-Yeong Kim, Dong-Gyu Hwang, In-Hyuk Ha
A prospective observational study was conducted in 524 lumbar intervertebral disc herniation (LDH) inpatients to report the long-term effects of complementary and alternative medicine (CAM) treatment. Participants received integrative CAM treatment during hospitalization, from June 2012 to May 2013, and long-term outcomes were assessed from July to August 2016. Numerical rating scales (NRSs) of back and leg pain, the Oswestry disability index (ODI), satisfaction, surgery, recurrence, and current care status were investigated...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28906432/total-power-radiometer-for-medical-sensor-applications-using-matched-and-mismatched-noise-sources
#11
Woojin Park, Jinho Jeong
This paper presents a simple total power radiometer to noninvasively measure the temperature of the human body. The proposed 3-GHz radiometer consists of an antenna collecting the noise power generated by a target, a low-noise and high-gain receiver amplifying the noise power, and a detector converting the noise power to voltage. A single-pole-triple-throw (SP3T) switch is placed between the antenna and the receiver, while a personal computer is used to control the SP3T switch, collect and process the data such as detector output voltages and physical temperatures of the reference noise sources and the target...
September 14, 2017: Sensors
https://www.readbyqxmd.com/read/28888284/long-term-consequences-of-youth-volunteering-voluntary-versus-involuntary-service
#12
Jinho Kim, Kerem Morgül
Despite the renewed interest in youth volunteering in recent years, there remain major gaps in our knowledge of its consequences. Drawing data from the National Longitudinal Study of Adolescent to Adult Health, we examine the long-term effects of youth volunteering on the civic and personal aspects of volunteers' lives. Our results suggest that youth volunteering has a positive return on adult volunteering only when it is voluntary, and that net of contextual factors neither voluntary nor involuntary youth service has a significant effect on adult voting...
September 2017: Social Science Research
https://www.readbyqxmd.com/read/28886539/exposure-to-lead-and-mercury-through-breastfeeding-during-the-first-month-of-life-a-check-cohort-study
#13
Yelim Park, Aram Lee, Kyungho Choi, Hai-Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sungjoo Kim, Su Young Kim, Geum Joon Cho, Eunsook Suh, Sung Koo Kim, So-Hee Eun, Soyong Eom, Seunghyo Kim, Gun-Ha Kim, Hyo-Bang Moon, Sungkyoon Kim, Sooran Choi, Young Don Kim, Jinho Kim, Jeongim Park
Mercury and lead are naturally occurring toxicants and are responsible for various health issues including neurobehavioral and developmental disorders. Because of crucial synchronized developmental processes occurring at the early stage of life, infancy and childhood are considered as among the most susceptible windows to the exposure to these metals. Breastmilk is often the only source of nutrition during the first months of life. As breastmilk can be contaminated with these metals, breastfeeding may serve as a significant route of heavy metal exposure among infants...
September 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28886511/electrochemical-nitric-oxide-biosensor-based-on-amine-modified-mos2-graphene-oxide-myoglobin-hybrid
#14
Jinho Yoon, Jae-Wook Shin, Joungpyo Lim, Mohsen Mohammadniaei, G Bharate Bapurao, Taek Lee, Jeong-Woo Choi
Nitric oxide (NO) is one of the most important molecules in living things due to its role as a signaling molecule in influencing pathological and physiological mechanisms including neurotransmission. In this study, the electrochemical biosensor based on the amine-modified molybdenum disulfide nanoparticles (MoS2), graphene oxide (GO) and myoglobin (Mb) hybrid material (amine-modified MoS2/GO/Mb hybrid) is developed to achieve the accurate detection of NO with electrochemical signal improvement. For the first time, the synthesis of MoS2 accompanying the amine-modification of the surface of MoS2 is done to hybridize with GO efficiently through the short linkage...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28879040/comparison-of-effects-between-calcium-channel-blocker-and-diuretics-in-combination-with-angiotensin-ii-receptor-blocker-on-24-h-central-blood-pressure-and-vascular-hemodynamic-parameters-in-hypertensive-patients-study-design-for-a-multicenter-double-blinded
#15
Gyu Chul Oh, Hae-Young Lee, Wook Jin Chung, Ho-Joong Youn, Eun-Joo Cho, Ki-Chul Sung, Shung Chull Chae, Byung-Su Yoo, Chang Gyu Park, Soon Jun Hong, Young Kwon Kim, Taek-Jong Hong, Dong-Ju Choi, Min Su Hyun, Jong Won Ha, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Soon-Gil Kim, Jinho Shin, Sungha Park, Il-Suk Sohn, Chong-Jin Kim
BACKGROUND: Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only half of them receive adequate treatment. Current guidelines on antihypertensive treatment recommend combination therapy for patients not responding to monotherapy, but as the number of pills increase, patient compliance tends to decrease. As a result, fixed-dose combination drugs with different antihypertensive agents have been developed and widely used in recent years...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28875163/functional-vascularized-lung-grafts-for-lung-bioengineering
#16
N Valerio Dorrello, Brandon A Guenthart, John D O'Neill, Jinho Kim, Katherine Cunningham, Ya-Wen Chen, Mauer Biscotti, Theresa Swayne, Holly M Wobma, Sarah X L Huang, Hans-Willem Snoeck, Matthew Bacchetta, Gordana Vunjak-Novakovic
End-stage lung disease is the third leading cause of death worldwide, accounting for 400,000 deaths per year in the United States alone. To reduce the morbidity and mortality associated with lung disease, new therapeutic strategies aimed at promoting lung repair and increasing the number of donor lungs available for transplantation are being explored. Because of the extreme complexity of this organ, previous attempts at bioengineering functional lungs from fully decellularized or synthetic scaffolds lacking functional vasculature have been largely unsuccessful...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28874589/dual-role-of-mitochondria-in-producing-melatonin-and-driving-gpcr-signaling-to-block-cytochrome-c-release
#17
Yalikun Suofu, Wei Li, Frédéric G Jean-Alphonse, Jiaoying Jia, Nicolas K Khattar, Jiatong Li, Sergei V Baranov, Daniela Leronni, Amanda C Mihalik, Yanqing He, Erika Cecon, Vanessa L Wehbi, JinHo Kim, Brianna E Heath, Oxana V Baranova, Xiaomin Wang, Matthew J Gable, Eric S Kretz, Giulietta Di Benedetto, Timothy R Lezon, Lisa M Ferrando, Timothy M Larkin, Mara Sullivan, Svitlana Yablonska, Jingjing Wang, M Beth Minnigh, Gérald Guillaumet, Franck Suzenet, R Mark Richardson, Samuel M Poloyac, Donna B Stolz, Ralf Jockers, Paula A Witt-Enderby, Diane L Carlisle, Jean-Pierre Vilardaga, Robert M Friedlander
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT1), its associated G protein, and β-arrestins are on and within neuronal mitochondria. We discovered that the ligand melatonin is exclusively synthesized in the mitochondrial matrix and released by the organelle activating the mitochondrial MT1 signal-transduction pathway inhibiting stress-mediated cytochrome c release and caspase activation...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28867687/rapid-exacerbation-of-renal-function-after-administration-of-hydroxyethyl-starch-in-a-dog
#18
Junwoo Bae, Mahmoud Soliman, Hyunwoo Kim, Seongwoo Kang, Woosun Kim, Soomin Ahn, Kyoungoh Cho, Jihye Choi, Suhee Kim, Jinho Park, Sangki Kim, Yoonjung DO, Jaegyu Yoo, Dohyeon Yu
Hydroxyethyl starches (HES) are commonly used synthetic colloidal solution in veterinary medicine. Despite of possible adverse effect to kidney injury in human, there is no report about nephrotoxic effects of HES in dogs. HES was administered to a Golden retriever (4-year-old, intact male) with ascites in order to increase plasma osmolality. Initially, the dog was mild azotemic, however, kidney function was rapidly deteriorated after several days of HES administration. Finally, histopathological examination revealed remarkable osmotic nephrosis...
September 29, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28860956/diagnosis-of-lymphoid-malignancy-by-pcr-for-analysis-of-antigen-receptor-rearrangement-after-blood-transfusion-in-a-dog-with-acute-lymphocytic-leukemia
#19
Suhee Kim, Hyunwoo Kim, Soo-Hyeon Lee, Ilhan Cho, Seongwoo Kang, Junwoo Bae, Woosun Kim, Soomin Ahn, Jihye Choi, Sang-Ki Kim, Yoonjung Do, Jae Gyu Yoo, Jinho Park, DoHyeon Yu
Acute lymphocytic leukemia (ALL) is uncommon lymphoid malignancy in dogs, and its diagnosis is challenging. A 14-year-old spayed female mixed breed dog was transferred to a veterinary medical teaching hospital for an immediate blood transfusion. The dog showed lethargy, pale mucous membranes, and a weak femoral pulse. Complete blood count revealed non-regenerative anemia and severe leukopenia with thrombocytopenia. ALL was tentatively diagnosed based on the predominance of immature lymphoblasts on blood film examination...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28857559/rational-design-of-in-vivo-tau-tangle-selective-near-infrared-fluorophores-expanding-the-bodipy-universe
#20
Peter Verwilst, Hye-Ri Kim, Jinho Seo, Nak-Won Sohn, Seung-Yun Cha, Yeongmin Kim, Sungho Maeng, Jung-Won Shin, Jong Hwan Kwak, Chulhun Kang, Jong Seung Kim
The elucidation of the cause of Alzheimer's disease remains one of the greatest questions in neurodegenerative research. The lack of highly reliable low-cost sensors to study the structural changes in key proteins during the progression of the disease is a contributing factor to this lack of insight. In the current work, we describe the rational design and synthesis of two fluorescent BODIPY-based probes, named Tau 1 and Tau 2. The probes were evaluated on the molecular surface formed by a fibril of the PHF6 ((306)VQIVYK(311)) tau fragment using molecular docking studies to provide a potential molecular model to rationalize the selectivity of the new probes as compared to a homologous Aβ-selective probe...
September 15, 2017: Journal of the American Chemical Society
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