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https://www.readbyqxmd.com/read/28078368/time-dependent-toxicity-responses-in-daphnia-magna-exposed-to-cuo-and-zno-nanoparticles
#1
Soyoun Kim, Palas Samanta, Jisu Yoo, Woo-Keun Kim, Jinho Jung
Aggregation and dissolution of CuO and ZnO nanoparticles (NPs) increased with increasing exposure time (24, 48, and 72 h). Acute toxicity of CuO NPs to Daphnia magna also increased significantly with increasing exposure time (p < 0.05), whereas exposure time did not significantly affect acute toxicity of ZnO NPs. The dissolved Cu concentration of CuO NPs was much lower than the median effective concentration (EC50) value (44 μg L(-1) at 72 h), implying that the increase in acute toxicity was caused by particles rather than by dissolved ions...
January 11, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28059128/c-terminus-of-hsc70-interacting-protein-chip-inhibits-adipocyte-differentiation-via-ubiquitin-and-proteasome-mediated-degradation-of-ppar%C3%AE
#2
Jung-Hoon Kim, Soyeon Shin, Jinho Seo, Eun-Woo Lee, Manhyung Jeong, Min-Sik Lee, Hyun-Ji Han, Jaewhan Song
PPARγ (Peroxisome proliferator-activated receptor γ) is a nuclear receptor involved in lipid homeostasis and related metabolic diseases. Acting as a transcription factor, PPARγ is a master regulator for adipocyte differentiation. Here, we reveal that CHIP (C-terminus of HSC70-interacting protein) suppresses adipocyte differentiation by functioning as an E3 ligase of PPARγ. CHIP directly binds to and induces ubiquitylation of the PPARγ protein, leading to proteasome-dependent degradation. Stable overexpression or knockdown of CHIP inhibited or promoted adipogenesis, respectively, in 3T3-L1 cells...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056846/biological-age-as-a-useful-index-to-predict-seventeen-year-survival-and-mortality-in-koreans
#3
Jinho Yoo, Yangseok Kim, Eo Rin Cho, Sun Ha Jee
BACKGROUND: Many studies have been conducted to quantitatively estimate biological age using measurable biomarkers. Biological age should function as a valid proxy for aging, which is closely related with future work ability, frailty, physical fitness, and/or mortality. A validation study using cohort data found biological age to be a superior index for disease-related mortality than chronological age. The purpose of this study is to demonstrate the validity of biological age as a useful index to predict a person's risk of death in the future...
January 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28052880/impact-of-visit-to-visit-variability-in-systolic-blood-pressure-on-cardiovascular-outcomes-in-korean-national-health-insurance-service-national-sample-cohort
#4
SeongIl Choi, Jinho Shin, Sung Yong Choi, Ki Chul Sung, Sang Hyun Ihm, Kwang-Il Kim, Yu-Mi Kim
BACKGROUND: Despite an association between visit-to-visit blood pressure (BP) variability (VV-BPV) and cardiovascular (CV) outcomes, many studies performed during the past 4 years have shown conflicting results. This study investigated the impact of VV-BPV on CV outcomes in the Korean National Health Insurance Service (NHIS) database-National Sample Cohort. METHODS: From the 2002 Korean NHIS database (n = 47,851,928), sample subjects with 3 or more BP measurements (n = 51,811) were divided into 2 groups according to a 10 mm Hg cutoff in the SD of systolic BP (SD-SBP)...
January 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28035833/correction-to-cu-catalyzed-aerobic-oxidation-of-di-tert-butyl-hydrazodicarboxylate-to-di-tert-butyl-azodicarboxylate-and-its-application-on-dehydrogenation-of-1-2-3-4-tetrahydroquinolines-under-mild-conditions
#5
https://www.readbyqxmd.com/read/28025981/brake-and-gas-pedals-in-motor-cortex
#6
Jinho Kim, S Andrew Hires
No abstract text is available yet for this article.
December 27, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/28024536/nanocellulose-based-asymmetric-composite-membrane-for-the-multiple-functions-in-cell-encapsulation
#7
Minsung Park, Sungchul Shin, Jie Cheng, Jinho Hyun
We describe the nanocomposite membrane for cell encapsulation using nanocelluose hydrogels. One of the surfaces of bacterial cellulose (BC) pellicles was coated with collagen to enhance cell adhesion and the opposite side of the BC pellicles was coated with alginate to protect transplanted cells from immune rejection by the reduced pore size of the composite membrane. The morphology of nanocomposite membrane was observed by scanning electron microscopy and the permeability of the membrane was estimated by the release test using different molecular weights of polymer solution...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27978631/cu-catalyzed-aerobic-oxidation-of-di-tert-butyl-hydrazodicarboxylate-to-di-tert-butyl-azodicarboxylate-and-its-application-on-dehydrogenation-of-1-2-3-4-tetrahydroquinolines-under-mild-conditions
#8
Dahyeon Jung, Min Hye Kim, Jinho Kim
A new class of co-catalytic system was developed with homogeneous CuI and di-tert-butyl azodicarboxylate for aerobic dehydrogenation of 1,2,3,4-tetrahydroquinolines under mild conditions. The developed co-catalytic system is consisting of di-tert-butyl azodicarboxylate-mediated dehydrogenation of 1,2,3,4-tetrahydroquinoline and aerobic oxidative regeneration of di-tert-butyl azodicarboxylate from di-tert-butyl hydrazodicarboxylate using molecular oxygen as a terminal oxidant. A variety of quinolines were efficiently synthesized by the developed Cu and di-tert-butyl azodicarboxylate co-catalytic system...
December 16, 2016: Organic Letters
https://www.readbyqxmd.com/read/27955988/electrochemical-h2o2-biosensor-composed-of-myoglobin-on-mos2-nanoparticle-graphene-oxide-hybrid-structure
#9
Jinho Yoon, Taek Lee, Bharate Bapurao G, Jinhee Jo, Byung-Keun Oh, Jeong-Woo Choi
In this research, the electrochemical biosensor composed of myoglobin (Mb) on molybdenum disulfide nanoparticles (MoS2 NP) encapsulated with graphene oxide (GO) was fabricated for the detection of hydrogen peroxide (H2O2). Hybrid structure composed of MoS2 NP and GO (GO@MoS2) was fabricated for the first time to enhance the electrochemical signal of the biosensor. As a sensing material, Mb was introduced to fabricate the biosensor for H2O2 detection. Formation and immobilization of GO@MoS2 was confirmed by transmission electron microscopy, ultraviolet-visible spectroscopy, scanning electron microscopy, and scanning tunneling microscopy...
December 7, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27930719/in-vitro-and-in-vivo-anti-allergic-and-anti-inflammatory-effects-of-ebv-a-newly-developed-derivative-of-bee-venom-through-modulation-of-irf3-signaling-pathway-in-a-carrageenan-induced-edema-model
#10
Hwa-Jin Chung, Jinho Lee, Joon-Shik Shin, Me-Riong Kim, Wonil Koh, Min-Jeong Kim, Jae-Woong Lee, Eun Jee Kim, In-Hee Lee, Won Kyung Kim, Yoon Jae Lee, Sang Kook Lee, In-Hyuk Ha
BACKGROUND: Bee venom (BV), a type of toxin extracted from honeybees (Apis mellifera), has been empirically and widely used to treat inflammatory diseases throughout Asia. Essential BV (eBV) was developed by removing phospholipase A2 (PLA2) and histamine to lower occurrence of allergic reaction. This study investigated the anti-allergic and anti-inflammatory activities of eBV in vitro and in vivo and its underlying mechanism of action. METHODS: The anti-inflammatory potential of eBV was assessed in vivo using a carrageenan-induced paw edema model...
2016: PloS One
https://www.readbyqxmd.com/read/27885700/heterogeneous-monolithic-integration-of-single-crystal-organic-materials
#11
Kyung Sun Park, Jangmi Baek, Yoonkyung Park, Lynn Lee, Jinho Hyon, Yong-Eun Koo Lee, Nabeen K Shrestha, Youngjong Kang, Myung Mo Sung
Manufacturing high-performance organic electronic circuits requires the effective heterogeneous integration of different nanoscale organic materials with uniform morphology and high crystallinity in a desired arrangement. In particular, the development of high-performance organic electronic and optoelectronic devices relies on high-quality single crystals that show optimal intrinsic charge-transport properties and electrical performance. Moreover, the heterogeneous integration of organic materials on a single substrate in a monolithic way is highly demanded for the production of fundamental organic electronic components as well as complex integrated circuits...
November 25, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27884133/recovering-disrupted-social-capital-insights-from-lao-dpr-rural-villagers-perceptions-of-local-leadership
#12
Jinho Kim, Ji-Hye Kim, Vanphanom Sychareun, Minah Kang
BACKGROUND: Social capital is often believed to be one of the key prerequisites for successful implementation of community-based health programs. In less-developed countries, local leaders are positioned as major players in broad community health strategies and interventions, and their capacities and roles are expected to increase in prominence in future community-health-care promotions. In this study, we examined how local leaders' capacities could be related to social capital in rural villages in Lao PDR, and thus to villagers' willingness to participate in community-based health efforts...
November 25, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27884090/aloe-qdm-complex-enhances-specific-cytotoxic-t-lymphocyte-killing-in-vivo-in-metabolic-disease-mice
#13
Youngjoo Lee, Jiyeon Kim, Jinho An, Heetae Lee, Hyunseok Kong, Youngcheon Song, Eunju Shin, Seon-Gil Do, Chong-Kil Lee, Kyungjae Kim
We developed spontaneous diet-induced metabolic disease in mice by feeding them a high-fat diet for 23 weeks and administered Aloe QDM complex for 16 weeks to examine its restorative effect on immune disorders and metabolic syndrome. A series of immune functional assays indicated Aloe QDM complex enhanced lymphocyte proliferation and antigen-specific immunity as determined by the restored functions of cytotoxic T lymphocytes (CTL) and IgG production. The elevated serum TNF-α level was also regulated by Aloe QDM complex treatment, which suggested its complex therapeutic potential...
November 25, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27867930/a-case-of-primary-central-nervous-system-lymphoma-located-at-brain-stem-in-a-child
#14
Jinho Kim, Young Zoon Kim
Primary central nervous system lymphoma (PCNSL) is an extranodal Non-Hodgkin's lymphoma that is confined to the brain, eyes, and/or leptomeninges without evidence of a systemic primary tumor. Although the tumor can affect all age groups, it is rare in childhood; thus, its incidence and prognosis in children have not been well defined and the best treatment strategy remains unclear. A nine-year old presented at our department with complaints of diplopia, dizziness, dysarthria, and right side hemiparesis. Magnetic resonance image suggested a diffuse brain stem glioma with infiltration into the right cerebellar peduncle...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27817011/genetic-characterization-of-theileria-orientalis-from-cattle-in-the-republic-of-korea
#15
Jinho Park, Yu-Jung Han, Du-Gyeong Han, Jeong-Byoung Chae, Joon-Seok Chae, Do-Hyeon Yu, Young-Sung Lee, Bae-Keun Park, Hyeon-Cheol Kim, Kyoung-Seong Choi
Theileria orientalis is the causative agent of benign theileriosis, which is distributed mainly in Asian countries, and causes serious economic losses in the livestock industry. The present study was performed to investigate the epidemiology of T. orientalis infections in cattle in the Republic of Korea (ROK) and to characterize the genetic diversity of T. orientalis based on the major piroplasm surface protein (MPSP) genes. In 2015, between July and August, blood samples were collected from 138 asymptomatic cattle in four different geographical regions (Hoengseong, Jeongeup, Namwon, and Jeju island) in the ROK...
January 2017: Parasitology Research
https://www.readbyqxmd.com/read/27793846/molecular-chaperone-hsp90-is-necessary-to-prevent-cellular-senescence-via-lysosomal-degradation-of-p14arf
#16
Su Yeon Han, Aram Ko, Haruhisa Kitano, Chel Hun Choi, Min-Sik Lee, Jinho Seo, Junya Fukuoka, Soo-Youl Kim, Stephen M Hewitt, Joon-Yong Chung, Jaewhan Song
The tumor suppressor function of p14ARF is regulated at a posttranslational level via mechanisms yet to be fully understood. Here, we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase C-terminus of HSP70-interacting protein (CHIP). The ternary complex of HSP90, CHIP, and p14ARF was required to induce the lysosomal degradation of p14ARF by an ubiquitination-independent but LAMP2A-dependent mechanism. Depletion of HSP90 or CHIP induced p14ARF-dependent senescence in human fibroblasts...
January 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/27792107/minimum-clinically-important-difference-and-substantial-clinical-benefit-in-pain-functional-and-quality-of-life-scales-in-failed-back-surgery-syndrome-patients
#17
Ki Byung Park, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jun-Hwan Lee, Kyung-Min Shin, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha
STUDY DESIGN: Prospective observational 1-year study OBJECTIVE.: To determine minimum clinically important difference (MCID) and substantial clinical benefit (SCB) of outcome measures in failed back surgery syndrome (FBSS) patients, as these metrics enable assessment of whether and when an intervention produces clinically meaningful effects in a patient SUMMARY OF BACKGROUND DATA.: Several methods have been devised to quantify clinically important difference, but MCID and SCB for FBSS patients has yet to be determined...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27769887/a-drug-delivery-strategy-for-overcoming-drug-resistance-in-breast-cancer-through-targeting-of-oncofetal-fibronectin
#18
Phei Er Saw, Jinho Park, Sangyong Jon, Omid C Farokhzad
A major problem with cancer chemotherapy begins when cells acquire resistance. Drug-resistant cancer cells typically upregulate multi-drug resistance proteins such as P-glycoprotein (P-gp). However, the lack of overexpressed surface biomarkers has limited the targeted therapy of drug-resistant cancers. Here we report a drug-delivery carrier decorated with a targeting ligand for a surface marker protein Extra-domain B(EDB) specific to drug-resistant breast cancer cells as a new therapeutic option for the aggressive cancers...
October 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27764239/association-between-knee-osteoarthritis-cardiovascular-risk-factors-and-the-framingham-risk-score-in-south-koreans-a-cross-sectional-study
#19
Ho Sun Kim, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Young-Hyeon Bae, Ki Byung Park, Eun-Jung Lee, Joo-Hee Kim, In-Hyuk Ha
BACKGROUND: Osteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS), which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors. METHODS: A total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173) released by the Korean Centers for Disease Control and Prevention was included for analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27754298/lbos-01-05-24-hour-central-blood-pressure-reduction-efficacy-of-calcium-channel-blocker-combination-is-superior-to-diuretics-combination-with-angiotensin-ii-receptor-blocker-especially-in-male-hypertensive-patients
#20
Eun Joo Cho, Hae Young Lee, Ki Chul Sung, Sungha Park, Chang Gyu Park, Dong-Ju Choi, Jong Won Ha, Young Keun Ahn, Jinho Shin, Soon-Jun Hong, Soon Kil Kim, Wook-Jin Chung, Byung Su Yoo, Taek Jong Hong, Ho Joong Youn, Myeong-Chan Cho, Shung Chull Chae, Young Jo Kim, Chong-Jin Kim
BACKGROUND: The aim of this study was to compare 24-hour central blood pressure (24 hr c-BP) reduction efficacy between angiotensin II receptor blocker (ARB) combined with calcium channel blocker and with diuretics. METHODS: We conducted a prospective, randomized, double-blind trial in 220 hypertensive patients [mean age = 59.6 ± 12.3 years, men = 154(70%)]. Patients received losartan 50 mg monotherapy for 4 weeks, followed by additional use of amlodipine 5 mg (L/A group) or hydrochlorothiazide 12...
September 2016: Journal of Hypertension
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