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https://www.readbyqxmd.com/read/29666662/prediction-of-gpcr-ligand-binding-using-machine-learning-algorithms
#1
Sangmin Seo, Jonghwan Choi, Soon Kil Ahn, Kil Won Kim, Jaekwang Kim, Jaehyuck Choi, Jinho Kim, Jaegyoon Ahn
We propose a novel method that predicts binding of G-protein coupled receptors (GPCRs) and ligands. The proposed method uses hub and cycle structures of ligands and amino acid motif sequences of GPCRs, rather than the 3D structure of a receptor or similarity of receptors or ligands. The experimental results show that these new features can be effective in predicting GPCR-ligand binding (average area under the curve [AUC] of 0.944), because they are thought to include hidden properties of good ligand-receptor binding...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29660331/biophysical-characterization-of-actin-bundles-generated-by-the-chlamydia-trachomatis-tarp-effector
#2
Susmita Ghosh, Jinho Park, Mitchell Thomas, Edgar Cruz, Omar Cardona, Hyeran Kang, Travis Jewett
Chlamydia trachomatis entry into host cells is mediated by pathogen-directed remodeling of the actin cytoskeleton. The chlamydial type III secreted effector, translocated actin recruiting phosphoprotein (Tarp), has been implicated in the recruitment of actin to the site of internalization. Tarp harbors G-actin binding and proline rich domains required for Tarp-mediated actin nucleation as well as unique F-actin binding domains implicated in the formation of actin bundles. Little is known about the mechanical properties of actin bundles generated by Tarp or the mechanism by which Tarp mediates actin bundle formation...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29651022/disposable-all-printed-electronic-biosensor-for-instantaneous-detection-and-classification-of-pathogens
#3
Shawkat Ali, Arshad Hassan, Gul Hassan, Chang-Ho Eun, Jinho Bae, Chong Hyun Lee, In-Jung Kim
A novel disposable all-printed electronic biosensor is proposed for a fast detection and classification of bacteria. This biosensor is applied to classify three types of popular pathogens: Salmonella typhimurium, and the Escherichia coli strains JM109 and DH5-α. The proposed sensor consists of inter-digital silver electrodes fabricated through an inkjet material printer and silver nanowires uniformly decorated on the electrodes through the electrohydrodynamic technique on a polyamide based polyethylene terephthalate substrate...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29625626/characteristics-and-status-of-korean-medicine-use-in-whiplash-associated-disorder-patients
#4
Nohyeon Kim, Byung-Cheul Shin, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Eui-Hyoung Hwang, Chan Yung Jung, Diana Ruan, In-Hyuk Ha
BACKGROUND: Patients are free to choose conventional or Korean medicine treatment under the dual medical system in Korea, and the prevalence of patients who choose Korean medicine treatment for whiplash-associated disorders (WADs) is high. This study analyzed the sociodemographic characteristics and medical service use in this population to provide healthcare providers with basic usage information of complementary and alternative medicine for WAD. METHODS: A total of 8291 outpatients who registered under automobile insurance coverage and visited the main branch of Jaseng Hospital of Korean Medicine from April 1, 2014 to August 10, 2016 were included...
April 6, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29623290/focusing-light-inside-scattering-media-with-magnetic-particle-guided-wavefront-shaping
#5
Haowen Ruan, Tom Haber, Yan Liu, Joshua Brake, Jinho Kim, Jacob M Berlin, Changhuei Yang
Optical scattering has traditionally limited the ability to focus light inside scattering media such as biological tissue. Recently developed wavefront shaping techniques promise to overcome this limit by tailoring an optical wavefront to constructively interfere at a target location deep inside scattering media. To find such a wavefront solution, a "guide-star" mechanism is required to identify the target location. However, developing guidestars of practical usefulness is challenging, especially in biological tissue, which hinders the translation of wavefront shaping techniques...
November 20, 2017: Optica
https://www.readbyqxmd.com/read/29618732/kovariome-korean-national-standard-reference-variome-database-of-whole-genomes-with-comprehensive-snv-indel-cnv-and-sv-analyses
#6
Jungeun Kim, Jessica A Weber, Sungwoong Jho, Jinho Jang, JeHoon Jun, Yun Sung Cho, Hak-Min Kim, Hyunho Kim, Yumi Kim, OkSung Chung, Chang Geun Kim, HyeJin Lee, Byung Chul Kim, Kyudong Han, InSong Koh, Kyun Shik Chae, Semin Lee, Jeremy S Edwards, Jong Bhak
High-coverage whole-genome sequencing data of a single ethnicity can provide a useful catalogue of population-specific genetic variations, and provides a critical resource that can be used to more accurately identify pathogenic genetic variants. We report a comprehensive analysis of the Korean population, and present the Korean National Standard Reference Variome (KoVariome). As a part of the Korean Personal Genome Project (KPGP), we constructed the KoVariome database using 5.5 terabases of whole genome sequence data from 50 healthy Korean individuals in order to characterize the benign ethnicity-relevant genetic variation present in the Korean population...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29607170/prognostic-factors-for-surgically-resected-non-small-cell-lung-cancer-with-cavity-formation
#7
Shunsuke Shigefuku, Yujin Kudo, Daisuke Yunaiyama, Jun Matsubayashi, Jinho Park, Toshitaka Nagao, Yoshihisa Shimada, Hisashi Saji, Masaru Hagiwara, Tetsuya Okano, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
Background: Small pulmonary nodules have been detected frequently by computed tomography (CT). Lung cancers with cavity formation are also easily detected. There are a few reports focused on the cavity wall, although cancer cells exist along the cavity wall, not inside. We evaluated the impact of cavity wall thickness on prognosis and assessed the clinicopathological features in non-small cell lung cancer (NSCLC) with cavity formation. Methods: Between 2005 and 2011, 1,313 patients underwent complete resection for NSCLC...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29588181/spectroelectrochemical-detection-of-microrna-155-based-on-functional-rna-immobilization-onto-ito-gnp-nanopattern
#8
Mohsen Mohammadniaei, Jinho Yoon, Taek Lee, Jeong-Woo Choi
We fabricated a microRNA biosensor using the combination of surface enhanced Raman spectroscopy (SERS) and electrochemical (EC) techniques. For the first time, the weaknesses of each techniques for microRNA detection was compensated by the other ones to give rise to the specific and wide-range detection of miR-155. A single stranded 3' methylene blue (MB) and 5' thiol-modified RNA (MB-ssRNA-SH) was designed to detect the target miR-155 and immobilized onto the gold nanoparticle-modified ITO (ITO/GNP). Upon the invasion of target strand, the double-stranded RNA transformed rapidly to an upright structure resulting in a notable decrease in SERS and redox signals of the MB...
March 24, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29573539/electrochemical-biosensor-composed-of-silver-ion-mediated-dsdna-on-au-encapsulated-bi-2-se-3-nanoparticles-for-the-detection-of-h-2-o-2-released-from-breast-cancer-cells
#9
Mohsen Mohammadniaei, Jinho Yoon, Taek Lee, Bapurao G Bharate, Jinhee Jo, Donghyun Lee, Jeong-Woo Choi
A newly developed electrochemical biosensor composed of a topological insulator (TI) and metallic DNA (mDNA) is fabricated. The bismuth selenide nanoparticle (Bi2 Se3 NP) is synthesized and sandwiched between the gold electrode and another Au-deposited thin layer (Bi2 Se3 @Au). Then, eight-silver-ion mediated double-stranded DNA (mDNA) is immobilized onto the substrate (Bi2 Se3 @Au-mDNA) for the further detection of hydrogen peroxide. The Bi2 Se3 NP acts as the electrochemical-signal booster, while unprecedentedly its encapsulation by the Au thin layer keeps the TI surface states protected, improves its electrochemical-signal stability and provides an excellent platform for the subsequent covalent immobilization of the mDNA through Au-thiol interaction...
March 24, 2018: Small
https://www.readbyqxmd.com/read/29565306/growth-and-brilliant-photo-emission-of-crystalline-hexagonal-column-of-alq%C3%A2-microwires
#10
Seokho Kim, Do Hyoung Kim, Jinho Choi, Hojin Lee, Sun-Young Kim, Jung Woon Park, Dong Hyuk Park
We report the growth and nanoscale luminescence characteristics of 8-hydroxyquinolinato aluminum (Alq₃) with a crystalline hexagonal column morphology. Pristine Alq₃ nanoparticles (NPs) were prepared using a conventional reprecipitation method. Crystal hexagonal columns of Alq₃ were grown by using a surfactant-assisted self-assembly technique as an adjunct to the aforementioned reprecipitation method. The formation and structural properties of the crystalline and non-crystalline Alq₃ NPs were analyzed with scanning electron microscopy and X-ray diffraction...
March 22, 2018: Materials
https://www.readbyqxmd.com/read/29542963/short-ballistic-josephson-coupling-in-planar-graphene-junctions-with-inhomogeneous-carrier-doping
#11
Jinho Park, Jae Hyeong Lee, Gil-Ho Lee, Yositake Takane, Ken-Ichiro Imura, Takashi Taniguchi, Kenji Watanabe, Hu-Jong Lee
We report on short ballistic (SB) Josephson coupling in junctions embedded in a planar heterostructure of graphene. Ballistic Josephson coupling is confirmed by the Fabry-Perot-type interference of the junction critical current I_{c}. The product of I_{c} and the normal-state junction resistance R_{N}, normalized by the zero-temperature gap energy Δ_{0} of the superconducting electrodes, turns out to be exceptionally large close to 2, an indication of strong Josephson coupling in the SB junction limit. However, I_{c} shows a temperature dependence that is inconsistent with the conventional short-junction-like behavior based on the standard Kulik-Omel'yanchuk prediction...
February 16, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29542777/thickness-dependent-and-anisotropic-thermal-conductivity-of-black-phosphorus-nanosheets
#12
Seong Gi Jeon, Hosun Shin, Yun Hwan Jaung, Jinho Ahn, Jae Yong Song
Thickness effects on thermal conductivities of black phosphorus nanosheets, which are anisotropic in the zigzag and armchair planar directions, are experimentally and theoretically investigated in the thickness range of 13 to 48 nm. The thermal conductivities decrease with the thickness, decreasing from 13 to 8 W m-1 K-1 in the zigzag direction and from 10 to 6 W m-1 K-1 in the armchair direction at 300 K, respectively. The anisotropic thermal conductivities, regardless of the thickness, might result from the anisotropic phonon velocity arising from the hinge-like structure...
March 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29538719/assessment-of-emphysema-severity-as-measured-on-three-dimensional-computed-tomography-images-for-predicting-respiratory-complications-after-lung-surgery
#13
Yojiro Makino, Yoshihisa Shimada, Masaru Hagiwara, Masatoshi Kakihana, Jinho Park, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
OBJECTIVES: Emphysema is one of the main causes of respiratory complications in patients operated on for lung cancer. We have used three-dimensional computed tomography (3D CT) for surgical simulations, as well as for depicting emphysematous areas as low attenuation areas (LAAs) and visual scores based on the Goddard classification (Goddard score), which is a visual scale of the area of vascular disruption and LAA for each lung field. This study aimed to investigate the effectiveness of the 3D CT function for assessing emphysema severity and its association with respiratory complications...
March 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29531020/implementation-of-a-multiplex-and-quantitative-proteomics-platform-for-assessing-protein-lysates-using-dna-barcoded-antibodies
#14
Jinho Lee, Gary K Geiss, Gokhan Demirkan, Christopher P Vellano, Brian Filanoski, Yiling Lu, Zhenlin Ju, Shuangxing Yu, Huifang Guo, Lisa Y Bogatzki, Warren E Carter, Rhonda K Meredith, Savitri Krishnamurthy, Zhiyong Ding, Joseph M Beechem, Gordon Mills
Molecular analysis of tumors forms the basis for personalized cancer medicine and increasingly guides patient selection for targeted therapy.  Future opportunities for personalized medicine are highlighted by the measurement of protein expression levels via immunohistochemistry, protein arrays, and other approaches; however, sample type, sample quantity, batch effects, and "time to result" are limiting factors for clinical application.  Here, we present a development pipeline for a novel multiplexed DNA-labeled antibody platform which digitally quantifies protein expression from lysate samples...
March 12, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29530058/molecular-detection-of-anaplasma-bovis-in-holstein-cattle-in-the-republic-of-korea
#15
Jinho Park, Du-Gyeong Han, Ji-Hyoung Ryu, Jeong-Byoung Chae, Joon-Seok Chae, Do-Hyeon Yu, Bae-Keun Park, Hyeon-Cheol Kim, Kyoung-Seong Choi
Anaplasmosis is a tick-borne infectious disease that affects both human and animal health. This study was performed to characterize and investigate the prevalence of infection with Anaplasma bovis in Holstein cattle originating from two regions in the Republic of Korea (ROK). Blood samples (n = 151; 80 from Namwon and 71 from Jeju Island) were analyzed by polymerase chain reaction, and the prevalence of A. bovis infection was compared before and after grazing. In Namwon, A. bovis infection was not detected, while in the Jeju Island, A...
March 12, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29495392/impact-of-genetic-variants-on-the-individual-potential-for-body-fat-loss
#16
Soyeon Cha, Joon Ho Kang, Jae-Hak Lee, Jinki Kim, Heewon Kim, Yoon Jung Yang, Woong-Yang Park, Jinho Kim
The past decade has witnessed the discovery of obesity-related genetic variants and their functions through genome-wide association studies. Combinations of risk alleles can influence obesity phenotypes with different degrees of effectiveness across various individuals by interacting with environmental factors. We examined the interaction between genetic variation and changes in dietary habits or exercise that influences body fat loss from a large Korean cohort ( n = 8840). Out of 673 obesity-related SNPs, a total of 100 SNPs (37 for carbohydrate intake; 19 for fat intake; 44 for total calories intake; 25 for exercise onset) identified to have gene-environment interaction effect in generalized linear model were used to calculate genetic risk scores (GRS)...
February 26, 2018: Nutrients
https://www.readbyqxmd.com/read/29488744/magnetic-oleosome-as-a-functional-lipophilic-drug-carrier-for-cancer-therapy
#17
Hyeon-Yeol Cho, Taek Lee, Jinho Yoon, Zhenlin Han, Hudifah Rabie, Ki Bum Lee, Wei Wen Su, Jeong-Woo Choi
In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs for cancer treatment. The bioengineered oleosome is composed of neutral lipids surrounded by a phospholipid monolayer with embedded oleosin fusion proteins. The oleosin was genetically fused to a nanobody of a green fluorescent protein (GFP). A recombinant protein consisting of immunoglobulin-binding protein LG fused to GFP was used to couple the oleosome to an antibody for targeted delivery to breast cancer cells...
February 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29482302/clinical-and-radiological-results-with-second-look-arthroscopic-findings-after-open-wedge-high-tibial-osteotomy-without-arthroscopic-procedures-for-medial-meniscal-root-tears
#18
Hyun Il Lee, Dongjun Park, Jinho Cho
Purpose: To identify the structural integrity of the healing site after medial open wedge high tibial osteotomy (MOWHTO) in patients with a posterior root tear of the medial meniscus (PRTMM) and chondral lesion by second-look arthroscopy and to determine the clinical and radiological findings. Materials and Methods: From August 2010 to June 2016, 52 consecutive patients underwent MOWHTO and arthroscopic examination without a chondral resurfacing procedure and meniscal treatment for PRTMM...
March 1, 2018: Knee Surgery & related Research
https://www.readbyqxmd.com/read/29479995/effect-of-acute-intradialytic-aerobic-and-resistance-exercise-on-one-day-blood-pressure-in-patients-undergoing-hemodialysis-a-pilot-study
#19
Joon-Sik Kim, Joo-Hark Yi, Jinho Shin, Yeon-Soo Kim, Sang-Woong Han
BACKGROUND: Hypertension and intradialytic hypotension are independent risk factors for mortality in hemodialysis patients. We hypothesized that intradialytic exercise would increase blood pressure (BP) during dialysis and decrease it during the postdialytic period. The present study aimed to investigate the effect of acute intradialytic exercise on BP both during dialysis and for 20 hours post-dialysis, and to detect any differences in effects of aerobic exercise (AE), resistance exercise (RE), and usual care (UC-the control condition)...
February 26, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29457970/synthesis-of-pd-nanoscale-octahedra-through-a-one-pot-dual-reductant-route-and-the-kinetic-analysis
#20
Younan Xia, Legna Figueroa-Cosme, Kyle D Gilroy, Tung-Han Yang, Madeline Vara, Jinho Park, Shixiong Bao, Anderson G M da Silva
Shape-controlled synthesis of colloidal metal nanocrystals has traditionally relied on the use of an approach that involves the reduction of a metal precursor by a single reductant. Once the concentration of the atoms surpasses supersaturation, they will undergo homogeneous nucleation to generate nuclei and then seeds, followed by further growth into nanocrystals. In general, it is a grand challenge to optimize such an approach because the kinetic requirement for nucleation tends to be drastically different from what is needed for guiding the growth process...
February 19, 2018: Chemistry: a European Journal
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