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https://www.readbyqxmd.com/read/27885700/heterogeneous-monolithic-integration-of-single-crystal-organic-materials
#1
Kyung Sun Park, Jangmi Baek, Yoonkyung Park, Lynn Lee, Jinho Hyon, Yong-Eun Koo Lee, Nabeen K Shrestha, Youngjong Kang, Myung Mo Sung
Manufacturing high-performance organic electronic circuits requires the effective heterogeneous integration of different nanoscale organic materials with uniform morphology and high crystallinity in a desired arrangement. In particular, the development of high-performance organic electronic and optoelectronic devices relies on high-quality single crystals that show optimal intrinsic charge-transport properties and electrical performance. Moreover, the heterogeneous integration of organic materials on a single substrate in a monolithic way is highly demanded for the production of fundamental organic electronic components as well as complex integrated circuits...
November 25, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27884133/recovering-disrupted-social-capital-insights-from-lao-dpr-rural-villagers-perceptions-of-local-leadership
#2
Jinho Kim, Ji-Hye Kim, Vanphanom Sychareun, Minah Kang
BACKGROUND: Social capital is often believed to be one of the key prerequisites for successful implementation of community-based health programs. In less-developed countries, local leaders are positioned as major players in broad community health strategies and interventions, and their capacities and roles are expected to increase in prominence in future community-health-care promotions. In this study, we examined how local leaders' capacities could be related to social capital in rural villages in Lao PDR, and thus to villagers' willingness to participate in community-based health efforts...
November 25, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27884090/aloe-qdm-complex-enhances-specific-cytotoxic-t-lymphocyte-killing-in-vivo-in-metabolic-disease-mice
#3
Youngjoo Lee, Jiyeon Kim, Jinho An, Heetae Lee, Hyunseok Kong, Youngcheon Song, Eunju Shin, Seon-Gil Do, Chong-Kil Lee, Kyungjae Kim
We developed spontaneous diet-induced metabolic disease in mice by feeding them a high-fat diet for 23 weeks and administered Aloe QDM complex for 16 weeks to examine its restorative effect on immune disorders and metabolic syndrome. A series of immune functional assays indicated Aloe QDM complex enhanced lymphocyte proliferation and antigen-specific immunity as determined by the restored functions of cytotoxic T lymphocytes (CTL) and IgG production. The elevated serum TNF-α level was also regulated by Aloe QDM complex treatment, which suggested its complex therapeutic potential...
November 25, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27867930/a-case-of-primary-central-nervous-system-lymphoma-located-at-brain-stem-in-a-child
#4
Jinho Kim, Young Zoon Kim
Primary central nervous system lymphoma (PCNSL) is an extranodal Non-Hodgkin's lymphoma that is confined to the brain, eyes, and/or leptomeninges without evidence of a systemic primary tumor. Although the tumor can affect all age groups, it is rare in childhood; thus, its incidence and prognosis in children have not been well defined and the best treatment strategy remains unclear. A nine-year old presented at our department with complaints of diplopia, dizziness, dysarthria, and right side hemiparesis. Magnetic resonance image suggested a diffuse brain stem glioma with infiltration into the right cerebellar peduncle...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27817011/genetic-characterization-of-theileria-orientalis-from-cattle-in-the-republic-of-korea
#5
Jinho Park, Yu-Jung Han, Du-Gyeong Han, Jeong-Byoung Chae, Joon-Seok Chae, Do-Hyeon Yu, Young-Sung Lee, Bae-Keun Park, Hyeon-Cheol Kim, Kyoung-Seong Choi
Theileria orientalis is the causative agent of benign theileriosis, which is distributed mainly in Asian countries, and causes serious economic losses in the livestock industry. The present study was performed to investigate the epidemiology of T. orientalis infections in cattle in the Republic of Korea (ROK) and to characterize the genetic diversity of T. orientalis based on the major piroplasm surface protein (MPSP) genes. In 2015, between July and August, blood samples were collected from 138 asymptomatic cattle in four different geographical regions (Hoengseong, Jeongeup, Namwon, and Jeju island) in the ROK...
November 6, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27793846/molecular-chaperone-hsp90-is-necessary-to-prevent-cellular-senescence-via-lysosomal-degradation-of-p14arf
#6
Su Yeon Han, Aram Ko, Haruhisa Kitano, Chel Hun Choi, Min-Sik Lee, Jinho Seo, Junya Fukuoka, Soo-Youl Kim, Stephen M Hewitt, Joon-Yong Chung, Jaewhan Song
The tumor suppressor function of p14ARF is regulated at a post-translational level via mechanisms yet to be fully understood. Here we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase CHIP. The ternary complex of HSP90, CHIP and p14ARF was required to induce the lysosomal degradation of p14ARF by a ubiquitination-independent but LAMP2A-dependent mechanism. Depletion of HSP90 or CHIP induced p14ARF-dependent senescence in human fibroblasts...
October 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27792107/minimum-clinically-important-difference-and-substantial-clinical-benefit-in-pain-functional-and-quality-of-life-scales-in-failed-back-surgery-syndrome-patients
#7
Ki Byung Park, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jun-Hwan Lee, Kyung-Min Shin, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha
STUDY DESIGN: Prospective observational 1-year study OBJECTIVE.: To determine minimum clinically important difference (MCID) and substantial clinical benefit (SCB) of outcome measures in failed back surgery syndrome (FBSS) patients, as these metrics enable assessment of whether and when an intervention produces clinically meaningful effects in a patient SUMMARY OF BACKGROUND DATA.: Several methods have been devised to quantify clinically important difference, but MCID and SCB for FBSS patients has yet to be determined...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27769887/a-drug-delivery-strategy-for-overcoming-drug-resistance-in-breast-cancer-through-targeting-of-oncofetal-fibronectin
#8
Phei Er Saw, Jinho Park, Sangyong Jon, Omid C Farokhzad
A major problem with cancer chemotherapy begins when cells acquire resistance. Drug-resistant cancer cells typically upregulate multi-drug resistance proteins such as P-glycoprotein (P-gp). However, the lack of overexpressed surface biomarkers has limited the targeted therapy of drug-resistant cancers. Here we report a drug-delivery carrier decorated with a targeting ligand for a surface marker protein Extra-domain B(EDB) specific to drug-resistant breast cancer cells as a new therapeutic option for the aggressive cancers...
October 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27764239/association-between-knee-osteoarthritis-cardiovascular-risk-factors-and-the-framingham-risk-score-in-south-koreans-a-cross-sectional-study
#9
Ho Sun Kim, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Young-Hyeon Bae, Ki Byung Park, Eun-Jung Lee, Joo-Hee Kim, In-Hyuk Ha
BACKGROUND: Osteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS), which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors. METHODS: A total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173) released by the Korean Centers for Disease Control and Prevention was included for analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27754298/lbos-01-05-24-hour-central-blood-pressure-reduction-efficacy-of-calcium-channel-blocker-combination-is-superior-to-diuretics-combination-with-angiotensin-ii-receptor-blocker-especially-in-male-hypertensive-patients
#10
Eun Joo Cho, Hae Young Lee, Ki Chul Sung, Sungha Park, Chang Gyu Park, Dong-Ju Choi, Jong Won Ha, Young Keun Ahn, Jinho Shin, Soon-Jun Hong, Soon Kil Kim, Wook-Jin Chung, Byung Su Yoo, Taek Jong Hong, Ho Joong Youn, Myeong-Chan Cho, Shung Chull Chae, Young Jo Kim, Chong-Jin Kim
BACKGROUND: The aim of this study was to compare 24-hour central blood pressure (24 hr c-BP) reduction efficacy between angiotensin II receptor blocker (ARB) combined with calcium channel blocker and with diuretics. METHODS: We conducted a prospective, randomized, double-blind trial in 220 hypertensive patients [mean age = 59.6 ± 12.3 years, men = 154(70%)]. Patients received losartan 50 mg monotherapy for 4 weeks, followed by additional use of amlodipine 5 mg (L/A group) or hydrochlorothiazide 12...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754195/br-06-1-clinical-applications-of-visit-to-visit-blood-pressure-variability
#11
Jinho Shin
Since the introduction of visit to visit blood pressure variability (VVBPV) for cardiovascular outcome, it has long been awaited for prospective intervention trial to reduce VVBPV for evidence based medicine. But because of several hurdles, most importantly, pending measure to reduce VVBPV, such trial may not be available in the near future. It means that current understanding on the VVBPV is not casual but related to the cardiovascular outcome.Waiting for more sound evidence, which can be remained in a clinician's mind struggling not to be indifferent for potential benefit? Firstly, the most important potential confounder in spite of the strict statistical analyses to be published may be the mean blood pressure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754183/hw-02-1-is-it-the-end-of-a-long-and-productive-era-the-future-of-the-mercury-sphygmomanometer-and-the-stethoscope
#12
Jinho Shin
Arterial pulsation which had long been studied for estimation of blood pressure or mean blood pressure was replaced by the measurement of systolic and diastolic blood pressure using Korotkoff sound detected by stethoscope in the beginning of the previous century. In the meantime, vast of modern knowledge of human hypertension from epidemiology to randomized clinical trial had been built on the Korotkoff sound and stethoscope methodology. Hypertension is very special clinical entity in terms of the diagnosis is solely dependent on the manual blood pressure measurement by a physician or nurse...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753943/os-06-08-the-impact-of-visit-to-visit-variability-in-blood-pressure-on-the-development-of-metabolic-syndrome-in-the-healthy-population-a-population-based-prospective-cohort-study-in-korea
#13
Hyung Tak Lee, Jinho Shin Shin, Jin-Kyu Park, Young-Hyo Lim
OBJECTIVE: The aim of this study is to evaluate the effect of visit-to-visit variability (VVV) of blood pressure (BP) on development of metabolic syndrome (Mets) in general population without cardiovascular disease, diabetes mellitus, MetS, and BP medication. DESIGN AND METHOD: We used data from the Korean Genome Epidemiology Study (KoGES) conducted by the Korean Centers for Disease Control and Prevention (KCDC). All cohorts who were followed first 3 periods without omission, formed the basis of the study sample, which consisted of 7195 people...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753911/os-03-03-possible-detection-of-individual-salt-sensitive-blood-pressure-elevation-by-24-hour-urinary-sodium-excretion-and-nighttime-heart-rate
#14
Yukio Yamori, Mari Mori, Miki Sagara, Fnshi Xu, Young Hyo Lim, Bo Youl Choi, Bee Keun Kim, Yong Gu Lee, Mi Kyung Kim, Jinho Shin
OBJECTIVE: Detection of individual difference in salt-induced blood pressure (BP) elevation is important to know who should reduce salt intake for preventing hypertension, but the diagnosis of salt sensitivity requires a time-consuming protocol for testing BP changes in response to salt loading and depletion. Since WHO-CARDIAC Study indicated BP was higher in the people excreting more 24-hour urinary (24U) salt with higher heart rate (HR), ambulatory BP was monitored in a Korean population to investigate the association of nighttime BP and HR with 24-hour urinary salt excretion for detecting salt sensitivity...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753909/os-03-01-higher-salt-intake-attenuates-nocturnal-dipping-in-blood-pressure-and-heart-rate
#15
Mari Mori, Miki Sagara, Fnshi Xu, Young Hyo Lim, Bo Youl Choi, Bee Keun Kim, Yong Gu Lee, Mi Kyung Kim, Yukio Yamori, Jinho Shin
OBJECTIVE: Objective: It is now established that "dippers" whose blood pressure (BP) falls at night have lower cardiovascular risks than nondippers without nocturnal BP fall. Our previous study on the middle-aged general population in Korea indicated increased 24-hour urinary (24U) sodium excretion was associated with increased nighttime BPs. Therefore, we further analyzed the association of salt intakes estimated by 24U analysis with dipping in nocturnal BP and heart rate. DESIGN AND METHOD: Design and method: In the rural area in South Korea 218 subjects aged 30 to 59 years were measured with casual and ambulatory BP monitoring (ABPM) (TM2430, A&D, Tokyo, Japan) and their 24U samples collected by aliquot cups were analyzed...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27743492/respiratory-reactance-in-children-aged-3-5-years-with-post-infectious-bronchiolitis-obliterans-is-higher-than-in-those-with-asthma
#16
Eun Lee, Jisun Yoon, Soo-Jong Hong, Jinho Yu
AIM: We investigated airway function in preschoolers with post-infectious bronchiolitis obliterans (PIBO) using impulse oscillometry (IOS). METHODS: This study enrolled 182 children aged 3-5 years: 12 with PIBO, 135 asthma with asthma and 35 non-atopic controls. Respiratory resistance and reactance were assessed using IOS. RESULTS: The percentage predicted (% predicted) of pre-bronchodilator respiratory resistance at 5Hz was significantly higher in children with PIBO (177...
October 15, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27737523/restoration-of-declined-immune-responses-and-hyperlipidemia-by-rubus-occidenalis-in-diet-induced-obese-mice
#17
Youngjoo Lee, Jiyeon Kim, Jinho An, Sungwon Lee, Heetae Lee, Hyunseok Kong, Youngcheon Song, Hye Ran Choi, Ji-Wung Kwon, Daekeun Shin, Chong-Kil Lee, Kyungjae Kim
Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical, and an immunological view has been suggested as a novel strategy, because hyperlipidemia is closely associated with inflammation and immune dysfunction. In this study, the effects of an aqueous extract of Rubus occidentalis (RO) in obese mice were investigated using immunological indexes. The mice were fed a high-fat diet (HFD) to induce hyperlipidemia, which was confirmed by biochemical analysis and examination of the mouse physiology...
October 17, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27722341/a-facile-room-temperature-chemical-transformation-approach-for-binder-free-thin-film-formation-of-ag2te-and-lithiation-delithiation-chemistry-of-the-film
#18
Eun-Kyung Kim, Dasom Park, Nabeen K Shrestha, Jinho Chang, Cheol-Woo Yi, Sung-Hwan Han
The present work demonstrates a highly controllable, facile and environmentally friendly aqueous solution based synthetic method for oxide contamination-free Ag2Te thin films on desired substrates at room temperature using ion exchange induced chemical transformation of Ag/AgxO thin films. The films before and after chemical transformation reaction are characterized using an energy dispersive X-ray analyzer, field emission scanning electron microscopy, X-ray photoelectron spectroscopy, thin film X-ray diffraction technique, high resolution transmission electron microscopy, and the selected area electron diffraction analysis technique...
October 10, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27718582/all-printed-differential-temperature-sensor-for-compensation-of-bending-effects
#19
Shawkat Ali, Arshad Hassan, Jinho Bae, Chong Hyun Lee, Juho Kim
Since printed resistance temperature detectors (RTDs) is affected by tension and compression of metallic pattern on flexible or curved surfaces, a significant temperature sensing error is occurred in general. Hence, we propose differential temperature sensor (DTS) to compensate the bending effect of the printed RTDs, which is composed of two serially connected similar meander patterns fabricated back-to-back on the polyimide polyethyleneterephthalate (PET) substrate through inkjet printer Dimatix DMP-3000 by using silver nanoparticles...
October 8, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27643338/os-06-08-the-impact-of-visit-to-visit-variability-in-blood-pressure-on-the-development-of-metabolic-syndrome-in-the-healthy-population-a-population-based-prospective-cohort-study-in-korea
#20
Hyung Tak Lee, Jinho Shin Shin, Jin-Kyu Park, Young-Hyo Lim
OBJECTIVE: The aim of this study is to evaluate the effect of visit-to-visit variability (VVV) of blood pressure (BP) on development of metabolic syndrome (Mets) in general population without cardiovascular disease, diabetes mellitus, MetS, and BP medication. DESIGN AND METHOD: We used data from the Korean Genome Epidemiology Study (KoGES) conducted by the Korean Centers for Disease Control and Prevention (KCDC). All cohorts who were followed first 3 periods without omission, formed the basis of the study sample, which consisted of 7195 people...
September 2016: Journal of Hypertension
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