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https://www.readbyqxmd.com/read/29031036/-the-role-of-chemotherapy-in-the-treatment-of-low-grade-gliomas
#1
R Lakomý, T Kazda, A Poprach, P Pospíšil, R Jančálek, P Šlampa
BACKGROUND: The standard postsurgical options for low-grade gliomas include watchful waiting or radiotherapy depending on the risk factors for recurrence. The use of chemotherapy for the treatment of this disease is generally controversial, although the recently published results of the first of two large randomized phase III clinical trials (RTOG 9802 a EORTC 22033-26033), focusing on the evaluation of chemotherapy for the upfront treatment of newly diagnosed low-grade gliomas, are reassuring in this respect...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031035/-controversy-in-the-postoperative-treatment-of-low-grade-gliomas
#2
T Kazda, R Lakomý, A Poprach, P Pospíšil, R Jančálek, P Šlampa
BACKGROUND: The optimal treatment for low-grade gliomas remains controversial. Neurosurgery, radiotherapy, and chemotherapy are the main treatment options. Despite advances in oncology, there are still a lot of uncertainties, and the optimal sequences, combinations, and timings of these procedures have not yet been optimized. It is still unclear whether temozolomide can replace effective, but toxic PCV chemotherapy (procarbazine, lomustine, vincristine) and whether temozolomide can be used upfront alone instead of radiotherapy alone...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29029354/cost-analysis-of-sending-routine-pathology-specimens-following-total-joint-arthroplasty-in-the-age-of-bundled-payments
#3
Hayden S Holbrook, Johannes F Plate, Maxwell K Langfitt, Jason E Lang, John S Shields
Bundled payment plans are being developed as a means to curb healthcare spending. Routine histology following total hip arthroplasties (THA) and total knee arthroplasties (TKA) is standard practice at many institutions. Recently, the value of this practice has been questioned as histologic diagnoses in THA and TKA rarely differ from the clinical diagnoses. The goal of this study is to identify discrepant and discordant diagnoses following THA and TKA at an academic medical center and to calculate the cost-saving potential in the setting of a bundled payment plan...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29029132/general-practitioners-strategies-in-consultations-with-immigrants-in-norway-practice-based-shared-reflections-among-participants-in-focus-groups
#4
Stefán Hjörleifsson, Elise Hammer, Esperanza Díaz
Background: Immigrants comprise 16.8% of the population in Norway and meet General Practitioners (GPs) as their first point of contact with most health care services as do others in Norway. While Norwegian GPs are not trained in cultural competence, little is known about the extent to which they see good care for immigrants as relying on specific strategies. Objectives: To explore the thoughts of GPs in Norway about strategies they might use with immigrant patients...
September 28, 2017: Family Practice
https://www.readbyqxmd.com/read/29028874/impaired-self-awareness-of-motor-disturbances-in-parkinson-s-disease
#5
Franziska Maier, George P Prigatano
Traditionally, anosognosia for cognitive or motor impairments in patients with Parkinson's disease (PD) was viewed as unlikely unless the patient was demented. More recent research has suggested that a portion of non-demented PD patients (30%-50%) in fact have impaired subjective awareness (ISA) of their motor impairments (ISAm). This empirical finding has implications for the clinical neuropsychological examination of PD patients and raises theoretical questions relevant to the broader study of anosognosia seen in other patient groups...
September 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028791/is-diacerein-an-alternative-for-the-treatment-of-osteoarthritis
#6
Anselmo Alegría, Sebastián Irarrázaval
INTRODUCTION: Among the possibilities for the management of osteoarthritis, different pharmacological alternatives have been proposed, being diacerein one of them due to its anti-inflammatory effect. However, diacerein clinical utility is not clear. METHODS: To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
October 12, 2017: Medwave
https://www.readbyqxmd.com/read/29028741/fundamental-epidemiology-terminology-and-measures-it-really-is-all-in-the-name
#7
Thomas R Vetter, Christine A Jesser
Epidemiology is the study of how disease is distributed in populations and the factors that influence or determine this distribution. Clinical epidemiology denotes the application of epidemiologic methods to questions relevant to patient care and provides a highly useful set of principles and methods for the design and conduct of quantitative clinical research. Validly analyzing, correctly reporting, and successfully interpreting the findings of a clinical research study often require an understanding of the epidemiologic terms and measures that describe the patterns of association between the exposure of interest (treatment or intervention) and a health outcome (disease)...
October 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29028552/risk-reducing-salpingo-oophorectomy-in-brca1-and-brca2-mutated-patients-an-evidence-based-approach-on-what-women-should-know
#8
REVIEW
F De Felice, C Marchetti, S M Boccia, A Romito, C M Sassu, M G Porpora, L Muzii, V Tombolini, P Benedetti Panici
This review is focused on the ovarian cancer risk reduction management in BRCA mutation carriers and is intended to assist with clinical decision-making. Obviously, treatment decisions must be based on the available evidence. Despite risk-reducing salpingo-oophorectomy is firmly recommended, several separate questions can be raised to address the variety of intense controversy of this approach. A special emphasis lies in the effective preventive surgical measure against ovarian cancer risk, in an attempt to detect the optimal timing and mitigate the impact on patients...
September 28, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29028466/is-acute-care-oriented-research-ethical-in-resource-limited-settings
#9
Anwar D Jackson, Harold W Neighbors
In this case scenario, a medical student, Jenny, is conducting congenital heart disease research in a resource-limited setting faced with water insecurity. She has concerns about how ethical it is for her to conduct advanced clinical research in a region with more basic health needs. The first commentary argues that advanced clinical research in resource-limited settings follows the ethical principle of beneficence and interactional justice but violates the principle of distributive justice. The second commentary questions whether beneficence is enough, since the Belmont Report states that beneficence is the obligation to simultaneously reduce harm and increase benefit...
October 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29028442/the-use-of-mobile-applications-among-adults-with-type-1-and-type-2-diabetes-results-from-the-second-miles-australia-miles-2-study
#10
Steven Trawley, Shaira Baptista, Jessica L Browne, Frans Pouwer, Jane Speight
BACKGROUND: While the number of diabetes-specific mobile applications (apps) continues to grow, there is a lack of knowledge about their actual use. METHODS: The second MILES (Management and Impact for Long-term Empowerment and Success)-Australia study was a national cross-sectional survey of the psychological, behavioral, and social aspects of diabetes for adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Associations between diabetes-specific app usage and demographic, clinical, and psychosocial variables were examined...
October 13, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29028375/health-disparities-in-patients-with-pulmonary-arterial-hypertension-a-blueprint-for-action-an-official-american-thoracic-society-statement
#11
Arunabh Talwar, Joe G N Garcia, Halley Tsai, Matthew Moreno, Tim Lahm, Roham T Zamanian, Roberto Machado, Steven M Kawut, Mona Selej, Stephen Mathai, Laura Hoyt D'Anna, Sonu Sahni, Erik J Rodriquez, Richard Channick, Karen Fagan, Michael Gray, Jessica Armstrong, Josanna Rodriguez Lopez, Vinicio de Jesus Perez
BACKGROUND: Health disparities have a major impact in the quality of life and clinical care received by minorities in the United States. Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder that affects children and adults and that, if untreated, results in premature death. The impact of health disparities in the diagnosis, treatment, and clinical outcome of patients with PAH has not been systematically investigated. OBJECTIVES: The specific goals of this research statement were to conduct a critical review of the literature concerning health disparities in PAH, identify major research gaps and prioritize direction for future research...
October 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#12
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
October 13, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29027894/editorial-the-clinical-and-economic-costs-of-treating-cervical-radiculopathy-the-age-old-question-of-the-anterior-versus-posterior-approach
#13
Anthony C Lau, Michael Y Wang
No abstract text is available yet for this article.
October 13, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29027820/using-cost-effectiveness-analysis-to-quantify-the-value-of-genomic-based-diagnostic-tests-recommendations-for-practice-and-research
#14
Eldon Spackman, Sebastian Hinde, Laura Bojke, Katherine Payne, Mark Sculpher
AIMS: New sequencing technologies allow increased opportunities to use genomic-based diagnostic tests (genomic tests) in routine clinical practice, which will impact healthcare budgets and patients' outcomes. This article aims to generate a list of recommendations on how the principles and methods of cost-effectiveness analysis (CEA) can be used to quantify the costs and benefits of genomic tests. METHODS: A systematic literature search identified publications describing the use of CEA to evaluate genomic tests...
October 13, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29027759/greek-physiotherapists-perspectives-on-rehabilitation-following-total-knee-replacement-a-descriptive-survey
#15
Maria Moutzouri, Nigel Gleeson, Evdokia Billis, Elias Tsepis, John Gliatis
BACKGROUND AND PURPOSE: In Greece, as in many countries, there is a scarcity of evidence in the type of physiotherapy services offered for the rehabilitation of total knee replacement (TKR). Despite the number of TKRs annually performed in Greece (over 10,000), there are no available clinical guidelines as to the content of best physiotherapy practice. The aim of this nationwide survey undertaken by physiotherapists treating TKR patients post-operatively was to record standard practice and services available in Greece...
October 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/29027607/developing-a-patient-reported-outcome-measure-for-hiv-care-on-perceived-barriers-to-antiretroviral-adherence-assessing-the-needs-of-hiv-clinicians-through-qualitative-analysis
#16
Isabelle Toupin, Kim Engler, David Lessard, Leo Wong, Andràs Lènàrt, Bruno Spire, François Raffi, Bertrand Lebouché
PURPOSE: To identify HIV clinicians' needs for the clinical use of a new patient-reported outcome measure (PRO) on barriers to antiretroviral therapy (ART) adherence. METHODS: In 2015, five focus groups with 31 clinicians from France were transcribed, coded with Atlas.ti, and submitted to a typological analysis. RESULTS: The analysis identified seven patient profiles, each tied to distinct barriers to adherence and to specific needs for the PRO's content, data collection and transmission...
October 13, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29027125/a-survey-of-modulated-radiotherapy-use-in-australia-new-zealand-in-2015
#17
Jeffrey Barber, Philip Vial, Paul White, Nick Menzies, Shrikant Deshpande, Regina Bromley, Nick Bennie, Shan Yau, Kristie Harrison
A survey of radiation oncology medical physics departments across Australia and New Zealand was conducted to assess the usage, commissioning and quality assurance of modulated radiotherapy techniques such as IMRT and VMAT. Survey responses were collected in April-May 2015 to snapshot current practice and historical implementation. The survey asked 142 questions, and is the most detailed survey of its kind published to date. Analysis of results at overall department level, as well as sub-analysis for different equipment and techniques in use, was performed...
October 12, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29026947/pet-guided-clinical-trials-in-hodgkin-lymphoma-to-agree-or-not-to-agree-that-is-the-reviewer-s-question
#18
EDITORIAL
A Gallamini, M Meignan
No abstract text is available yet for this article.
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29026761/postherpetic-neuralgia-diabetic-neuropathy-and-trigeminal-neuralgia-chronic-peripheral-neuropathic-pain-in-58-480-rural-italian-primary-care-patients
#19
Nicola Buono, Hans Thulesius, Ferdinando Petrazzuoli, Elena Castelli, Marco Cambielli
INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care. AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy. MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026602/re-phrasing-the-question-a-simple-tool-for-evaluation-of-adherence-to-therapy-in-patients-with-inflammatory-bowel-disease
#20
T Engel, B Ungar, G Ben-Haim, N Levhar, R Eliakim, S Ben-Horin
BACKGROUND: Non-adherence to medication in patients with inflammatory bowel disease (IBD) is a challenging problem which is often overlooked or under-estimated by the physician or denied by the patient. We aimed to examine if re-phrasing the wording of the question used by the physician could help in revealing more patients who are non-adherent, and for whom appropriate counseling may be instituted. METHODS: A cross-sectional questionnaire-based study of IBD patients treated in a tertiary center was conducted...
October 2017: United European Gastroenterology Journal
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