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https://www.readbyqxmd.com/read/29667850/a-survey-of-fellowship-trained-upper-extremity-surgeons-on-treatment-of-lateral-epicondylitis
#1
Steven R Niedermeier, Nisha Crouser, Amy Speeckaert, Kanu S Goyal
BACKGROUND: The aim of the study is to investigate current management strategies for lateral epicondylitis by fellowship-trained upper extremity surgeons. METHODS: A 17-question survey of treatment approaches and outcomes related to lateral epicondylitis was sent to 3354 surgeons using the American Society for Surgery of the Hand and American Shoulder and Elbow Surgeons member databases. RESULTS: Six hundred twelve upper extremity surgeons completed the survey...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29667573/molecular-epidemiology-of-extraintestinal-pathogenic-escherichia-coli
#2
James R Johnson, Thomas A Russo
Extraintestinal pathogenic Escherichia coli (ExPEC) are important pathogens in humans and certain animals. Molecular epidemiological analyses of ExPEC are based on structured observations of E. coli strains as they occur in the wild. By assessing real-world phenomena as they occur in authentic contexts and hosts, they provide an important complement to experimental assessment. Fundamental to the success of molecular epidemiological studies are the careful selection of subjects and the use of appropriate typing methods and statistical analysis...
April 2018: EcoSal Plus
https://www.readbyqxmd.com/read/29667566/us-emergency-medical-services-fellows
#3
Brian Clemency, Christian Martin-Gill, Nicole Rall, Dipesh Patel, Jeffery Myers
IntroductionThe 2015-2016 academic year was the fourth year since the Accreditation Council for Graduate Medical Education (ACGME; Chicago, Illinois USA) accredited Emergency Medical Services (EMS) fellowships, and the first year an in-training examination was given. Soon, ACGME-accredited fellowship education will be the sole path to EMS board certification when the practice pathway closes after 2019. This project aimed to describe the current class of EMS fellows at ACGME-accredited programs and their current educational opportunities to better understand current and future needs in EMS fellowship education...
April 18, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29667552/harvesting-isolation-and-differentiation-of-rat-adipose-derived-stem-cells
#4
Panayiotis D Megaloikonomos, Georgios N Panagopoulos, Myrto Bami, Vasileios G Igoumenou, Leonidas Dimopoulos, Adamantia Milonaki, Maria Kyriakidou, Evanthia Mitsiokapa, Jane Anastassopoulou, Andreas F Mavrogenis
BACKGROUND: Adipose tissue is one of the most attractive source of stem cells because it can be easily harvested and yields a greater stromal cell density. The multi-lineage potential of adipose-derived stem cells (ADSCs) demonstrates their significant impact within the field of tissue engineering, with studies successfully demonstrating the ability to produce a range of tissue types. However, although, a broad spectrum of applications has already been suggested, many important scientific and medical questions remain unanswered before the clinical application of ADSCs in humans...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29667543/assessment-of-parents-guardians-initial-comprehension-and-1-day-recall-of-elements-of-informed-consent-within-a-mozambican-study-of-pediatric-bacteremia
#5
Ezequiel B Ossemane, Troy D Moon, Jahit Sacarlal, Esperança Sevene, Darlene Kenga, Wu Gong, Elizabeth Heitman
Participants' understanding of key elements of a research protocol is essential to their ethical enrollment in the study. Ongoing participation should be based on continued comprehension and consent, which presumes a high degree of recall. Many obstacles can prevent full understanding of information about the research protocol. This study's aim was to evaluate the comprehension and 1-day recall of the elements of informed consent by the parents/guardians of children enrolled in a clinical study in Mozambique...
April 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29667443/implications-of-structural-and-functional-brain-changes-in-amyotrophic-lateral-sclerosis
#6
Thanuja Dharmadasa, William Huynh, Jun Tsugawa, Yoshimitsu Shimatani, Yan Ma, Matthew C Kiernan
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive muscle weakness and disability, eventually leading to death. Heterogeneity of disease has become a major barrier to understanding key clinical questions such as prognosis and disease spread, and has disadvantaged clinical trials in search of therapeutic intervention. Patterns of disease have been explored through recent advances in neuroimaging, elucidating structural, molecular and functional changes. Unique brain signatures have emerged that have lent a greater understanding of critical disease mechanisms, offering opportunities to improve diagnosis, guide prognosis, and establish candidate biomarkers to direct future therapeutic strategies...
April 19, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#7
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667175/first-line-drugs-for-hypertension
#8
REVIEW
James M Wright, Vijaya M Musini, Rupam Gill
BACKGROUND: This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that question. OBJECTIVES: To quantify the mortality and morbidity effects from different first-line antihypertensive drug classes: thiazides (low-dose and high-dose), beta-blockers, calcium channel blockers, ACE inhibitors, angiotensin II receptor blockers (ARB), and alpha-blockers, compared to placebo or no treatment...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667126/treatment-of-submassive-and-massive-pulmonary-embolism-a-clinical-practice-survey-from-the-second-annual-meeting-of-the-pulmonary-embolism-response-team-consortium
#9
Thomas M Todoran, Jay Giri, Geoffrey D Barnes, Rachel P Rosovsky, Yuchiao Chang, Michael R Jaff, Kenneth Rosenfield, Christopher Kabrhel
There is a paucity of robust clinical trial data to guide the treatment of acute pulmonary embolism (PE) thus the clinical guidelines rely heavily on expert opinion. Pulmonary Embolism Response Teams (PERT) have been developed to streamline the care of patients with acute PE. We conducted a survey among 100 experts in the field of PE during the second annual meeting of the PERT Consortium. Respondents were queried with respect to their demographic information, clinical practice questions and clinical vignettes...
April 17, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29666813/ground-glass-opacities-management-in-the-lung-cancer-screening-era
#10
REVIEW
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Paolo Vigneri, Marco Nardini, Joel Dunning
Pulmonary ground glass opacity (GGO) is becoming an important clinical dilemma in oncology as its diagnosis in clinical practice is increasing due to the introduction of low dose computed tomography (CT) scan and screening. The incidence of cancer in GGO has been reported as high as 63%. The purpose of this manuscript is to review best available evidence papers on management of GGO in lung cancer to address the following questions: (I) how to correlate CT findings with malignancy; (II) when and who operate? (III) how to perform intraoperative detection of intrapulmonary GGO? (IV) wedge, segmentectomy or lobectomy? Taking a cue from a clinical scenario, a review on PubMed was conducted...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666682/knowledge-and-attitudes-towards-clinical-trial-participation-in-oman-a-cross-sectional-study
#11
Hussain Al-Lawati, Khalid Al-Baimani, Mahra Al-Zadjali, Nasra Al-Obaidani, Ziyana Al-Kiyumi, Murtadha K Al-Khabori
Objectives: Clinical trials are prospective studies on human subjects designed to answer various clinical questions. However, only a limited number of clinical trials have been conducted in Oman. This study aimed to assess the knowledge and attitudes of Omani patients and their relatives towards participating in clinical trials. Methods: This cross-sectional study was conducted between October 2015 and March 2016 among 174 patients and relatives attending the Haematology and Oncology Outpatient Clinics and Day Care Unit of the Sultan Qaboos University Hospital, Muscat, Oman...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666649/oral-cancer-knowledge-assessment-newly-graduated-versus-senior-dental-clinicians
#12
Gisele Pavão Spaulonci, Ricardo Salgado de Souza, Vanessa Gallego Arias Pecorari, Luciano Lauria Dib
The present study assessed the level of dentists' knowledge regarding oral cancer in the city of São Paulo, Brazil. A questionnaire was used to compare the level of knowledge among newly graduated and senior clinicians. A total of 20,154 e-mails were correctly delivered to the dentists registered in the database of the Regional Dentistry Council of São Paulo, and 477 (2.36%) responses were received. This sample consisted of 84 newly graduated clinicians and 105 senior clinicians. For the statistical analysis, the chi-square test and the logistic regression analysis were performed with α  = 0...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/29666176/registry-based-randomised-clinical-trial-efficient-evaluation-of-generic-pharmacotherapies-in-the-contemporary-era
#13
REVIEW
Troels Yndigegn, Robin Hofmann, Tomas Jernberg, Chris P Gale
Randomised clinical trials are the gold standard for testing the effectiveness of clinical interventions. However, increasing complexity and associated costs may limit their application in the investigation of key cardiovascular knowledge gaps such as the re-evaluation of generic pharmacotherapies. The registry-based randomised clinical trial (RRCT) leverages data sampling from nationwide quality registries to facilitate high participant inclusion rates at comparably low costs and, therefore, may offer a mechanism by which such clinical questions may be answered...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29666140/understanding-students-and-clinicians-experiences-of-informal-interprofessional-workplace-learning-an-australian-qualitative-study
#14
Charlotte E Rees, Paul Crampton, Fiona Kent, Ted Brown, Kerry Hood, Michelle Leech, Jennifer Newton, Michael Storr, Brett Williams
OBJECTIVES: While postgraduate studies have begun to shed light on informal interprofessional workplace learning, studies with preregistration learners have typically focused on formal and structured work-based learning. The current study investigated preregistration students' informal interprofessional workplace learning by exploring students' and clinicians' experiences of interprofessional student-clinician (IPSC) interactions. DESIGN: A qualitative interview study using narrative techniques was conducted...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665993/the-road-less-traveled-should-we-omit-prophylactic-cranial-irradiation-for-patients-with-small-cell-lung-cancer
#15
Terence T Sio, Anussara Prayongrat, Yun Zhang, Qin Lin, Ting Xu, Zhongxing Liao, Jinbo Yue
New randomized data from Japan have raised questions regarding the use of prophylactic cranial irradiation for patients with extensive-stage small-cell lung cancer but without detectable brain metastases on magnetic resonance imaging. In the present focused review, we examine the general role of prophylactic cranial irradiation in the management of small-cell lung cancer and present relevant controversies from both sides of the discussion. Future directions for clinical investigation and research are also highlighted...
March 16, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29665988/mild-suppression-of-hyperinsulinemia-to-treat-obesity-and-insulin-resistance
#16
REVIEW
Melissa M Page, James D Johnson
Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood glucose levels. Excessive circulating insulin is associated with adipose tissue expansion and obesity, yet a causal role for hyperinsulinemia in the development of mammalian obesity has proven controversial, with many researchers suggesting it as a consequence of insulin resistance. Recently, evidence that specifically reducing hyperinsulinemia can prevent and reverse obesity in animal models has been presented...
April 14, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29665558/prevalence-of-clostridium-difficile-infection-in-hospitalized-patients-with-diarrhoea-results-of-a-polish-multicenter-prospective-biannual-point-prevalence-study
#17
Hanna Pituch, Piotr Obuch-Woszczatyński, Dominika Lachowicz, Robert Kuthan, Katarzyna Dzierżanowska-Fangrat, Agnieszka Mikucka, Katarzyna Jermakow, Aleksandra Pituch-Zdanowska, Kerrie Davies
PURPOSE: We aimed to measure the underdiagnosis of Clostridium difficile infection across Poland and the distribution of PCR-ribotypes of C. difficile. MATERIAL AND METHODS: Twenty seven Polish healthcare facilities (HCFs) participated in this prospective study. Each HCF systematically sent all diarrhoeal stools received from inpatients at their laboratories on two days (one in January 2013 and one in July 2013), independently of CDI test request, to the National Coordinating Laboratory (NCL) for standardized testing of CDI...
April 13, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29665247/how-do-we-know-if-a-clinical-practice-guideline-is-good-a-response-to-djulbegovic-and-colleagues-use-of-fast-and-frugal-decision-trees-to-improve-clinical-care-strategies
#18
Mathew Mercuri
Clinical practice guidelines (CPGs) and clinical pathways have become important tools for improving the uptake of evidence-based care. Where CPGs are good, adherence to the recommendations within is thought to result in improved patient outcomes. However, the usefulness of such tools for improving patient important outcomes depends both on adherence to the guideline and whether or not the CPG in question is good. This begs the question of what it is that makes a CPG good? In this issue of the Journal, Djulbegovic and colleagues offer a theory to help guide the development of CPGs...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29665019/evidence-based-medicine-for-every-day-everyone-and-every-therapeutic-study
#19
REVIEW
Raghav Govindarajan, Pushpa Narayanaswami
The rapid growth in published medical literature makes it difficult for clinicians to keep up with advances in their fields. This may result in a cursory scan of the abstracts and conclusions of a study without critically evaluating study quality. The application of Evidence-Based Medicine (EBM) is the process of converting the abstract task of reading the literature into a practical method of using the literature to inform care in a specific clinical context while simultaneously expanding one's knowledge. EBM involves 4 steps: stating the clinical problem in a defined question; searching the literature for the evidence; critically appraising the evidence for its validity and applying the evidence in the context of the patient's situation, preferences and values...
April 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29664530/-clinical-practice-guidelines-for-smoking-cessation
#20
María Paz Corvalán B, Leonardo Véjar M, Claudia Bambs S, Juana Pavié G, Mónica Zagolin B, Jaime Cerda L
Considering that a high proportion of the Chilean general population smokes, the Chilean Society of Respiratory Diseases in collaboration with the Chilean Societies of Cardiology and, Endocrinology and Diabetes, formed an interdisciplinary group, who issued a set of recommendations for the treatment of the smoker, methodologically advised by experts. These interventions should be prioritized in high-risk groups. Methods The panel elaborated and graded the recommendations following the GRADE methodology. To assess the effect of each intervention, systematic reviews and randomized clinical trials were identified...
November 2017: Revista Médica de Chile
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