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Lu Chen

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https://www.readbyqxmd.com/read/29786888/injectable-bioresponsive-gel-depot-for-enhanced-immune-checkpoint-blockade
#1
Shuangjiang Yu, Chao Wang, Jicheng Yu, Jinqiang Wang, Yue Lu, Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He, Xuesi Chen, Zhen Gu
Although cancer immunotherapy based on immune checkpoint inhibitors holds great promise toward many types of cancers, several challenges still remain, associated with low objective response of patient rate as well as systemic side effects. Here, a combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species (ROS)-responsive polypeptide gel for sustained release of anti-programmed cell death-ligand 1 antibody and dextro-1-methyl tryptophan, inhibitor of indoleamine-2,3-dioxygenase with leveraging the ROS level in the tumor microenvironment...
May 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29786076/c-myc-inhibits-myoblast-differentiation-and-promotes-myoblast-proliferation-and-muscle-fibre-hypertrophy-by-regulating-the-expression-of-its-target-genes-mirnas-and-lincrnas
#2
Wen Luo, Jiahui Chen, Limin Li, Xueyi Ren, Tian Cheng, Shiyi Lu, Raman Akinyanju Lawal, Qinghua Nie, Xiquan Zhang, Olivier Hanotte
The transcription factor c-Myc is an important regulator of cellular proliferation, differentiation and embryogenesis. While c-Myc can inhibit myoblast differentiation, the underlying mechanisms remain poorly understood. Here, we found that c-Myc does not only inhibits myoblast differentiation but also promotes myoblast proliferation and muscle fibre hypertrophy. By performing chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq), we identified the genome-wide binding profile of c-Myc in skeletal muscle cells...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29785600/performance-and-microbial-community-of-cic-anaerobic-reactor-treating-food-waste-under-different-grease-contents-and-inner-circulation-ratio
#3
Chengyuan Su, Lijian Zhao, Liming Liao, Jingjing Qin, Yuxiang Lu, Menglin Chen, Mei Huang, Zhi Huang
High concentrations of grease easily inhibit anaerobic digestion. The stability of the process and microbial responses in the controlling internal circulation (CIC) reactor used for treating food waste were investigated under different grease contents and inner circulation ratios. Results showed that at the grease content of 1 g/L, the removal rates of 94% and 86-93% were achieved for chemical oxygen demand (COD) and NH3 -N, respectively. In contrast, when the grease content increased to 7 g/L, removal rates for COD and NH3 -N significantly decreased to 42...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785057/computational-redesign-of-enzymes-for-regio-and-enantioselective-hydroamination
#4
Ruifeng Li, Hein J Wijma, Lu Song, Yinglu Cui, Marleen Otzen, Yu'e Tian, Jiawei Du, Tao Li, Dingding Niu, Yanchun Chen, Jing Feng, Jian Han, Hao Chen, Yong Tao, Dick B Janssen, Bian Wu
Introduction of innovative biocatalytic processes offers great promise for applications in green chemistry. However, owing to limited catalytic performance, the enzymes harvested from nature's biodiversity often need to be improved for their desired functions by time-consuming iterative rounds of laboratory evolution. Here we describe the use of structure-based computational enzyme design to convert Bacillus sp. YM55-1 aspartase, an enzyme with a very narrow substrate scope, to a set of complementary hydroamination biocatalysts...
May 21, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29785051/hyaluronan-negatively-regulates-vascular-calcification-involving-bmp2-signaling
#5
Yonglun Kong, Qingchun Liang, Yanting Chen, Pingzhen Yang, Xiaoyu Liu, Yining Li, Siyuan Feng, Ji Wu, Wantao Liu, Jingyi Tang, Huimin Yu, Jing-Song Ou, Lihe Lu, Jianyun Yan
Vascular calcification is a highly regulated biological process similar to bone formation involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Hyaluronan (HA), a major structural component of the extracellular matrix in cartilage, has been shown to inhibit osteoblast differentiation. However, whether HA affects osteogenic differentiation and calcification of VSMCs remains unclear. In the present study, we used in vitro and ex vivo models of vascular calcification to investigate the role of HA in vascular calcification...
May 21, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29784977/cryptococcus-neoformans-sexual-reproduction-is-controlled-by-a-quorum-sensing-peptide
#6
Xiuyun Tian, Guang-Jun He, Pengjie Hu, Lei Chen, Changyu Tao, Ying-Lu Cui, Lan Shen, Weixin Ke, Haijiao Xu, Youbao Zhao, Qijiang Xu, Fengyan Bai, Bian Wu, Ence Yang, Xiaorong Lin, Linqi Wang
Bacterial quorum sensing is a well-characterized communication system that governs a large variety of collective behaviours. By comparison, quorum sensing regulation in eukaryotic microbes remains poorly understood, especially its functional role in eukaryote-specific behaviours, such as sexual reproduction. Cryptococcus neoformans is a prevalent fungal pathogen that has two defined sexual cycles (bisexual and unisexual) and is a model organism for studying sexual reproduction in fungi. Here, we show that the quorum sensing peptide Qsp1 serves as an important signalling molecule for both forms of sexual reproduction...
May 21, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29784821/characterization-of-gossypol-biosynthetic-pathway
#7
Xiu Tian, Ju-Xin Ruan, Jin-Quan Huang, Chang-Qing Yang, Xin Fang, Zhi-Wen Chen, Hui Hong, Ling-Jian Wang, Ying-Bo Mao, Shan Lu, Tian-Zhen Zhang, Xiao-Ya Chen
Gossypol and related sesquiterpene aldehydes in cotton function as defense compounds but are antinutritional in cottonseed products. By transcriptome comparison and coexpression analyses, we identified 146 candidates linked to gossypol biosynthesis. Analysis of metabolites accumulated in plants subjected to virus-induced gene silencing (VIGS) led to the identification of four enzymes and their supposed substrates. In vitro enzymatic assay and reconstitution in tobacco leaves elucidated a series of oxidative reactions of the gossypol biosynthesis pathway...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29784544/classifying-alzheimer-s-disease-with-brain-imaging-and-genetic-data-using-a-neural-network-framework
#8
Kaida Ning, Bo Chen, Fengzhu Sun, Zachary Hobel, Lu Zhao, Will Matloff, Arthur W Toga
A long-standing question is how to best use brain morphometric and genetic data to distinguish Alzheimer's disease (AD) patients from cognitively normal (CN) subjects and to predict those who will progress from mild cognitive impairment (MCI) to AD. Here, we use a neural network (NN) framework on both magnetic resonance imaging-derived quantitative structural brain measures and genetic data to address this question. We tested the effectiveness of NN models in classifying and predicting AD. We further performed a novel analysis of the NN model to gain insight into the most predictive imaging and genetics features and to identify possible interactions between features that affect AD risk...
April 24, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29784392/simultaneous-detection-of-multiple-inherited-metabolic-diseases-using-gc-ms-urinary-metabolomics-by-chemometrics-multi-class-classification-strategies
#9
Qin Yang, Lu Xu, Li-Juan Tang, Jiang-Tao Yang, Ben-Qing Wu, Nan Chen, Jian-Hui Jiang, Ru-Qin Yu
Metabonomics has been widely used in disease diagnosis and clinically practical methods often require the detection of multi-class bio-samples. In this work, multi-class classification methods were investigated to simultaneously discriminate among 6 inherited metabolic diseases (IMDs) and the normal instances using gas chromatography-mass spectrometry (GC-MS) of urine samples. Two common multi-class classification strategies, one-against-all (OAA) and one-against-one (OAO) were compared and enhanced using a novel ensemble classification strategy (ECS), which developed a set of sequential sub-classifiers by fusion of OAA and OAO and made the final classification decisions using softmax function...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784386/fabrication-of-powdery-polymer-aerogel-as-the-stationary-phase-for-high-resolution-gas-chromatographic-separation
#10
Juan Zheng, Cuiming Lu, Junlong Huang, Luyi Chen, Chuyi Ni, Xintong Xie, Fang Zhu, Dingcai Wu, Gangfeng Ouyang
Novel powdery polymer aerogel (PPA) prepared via the (micro)emulsion polymerization and the following hyper crosslinking reaction was fabricated as stationary phase of capillary column for the first time. Due to its powdery morphology, unique 3D nano-network structure, high surface area and good thermostability, the PPA-coated capillary column demonstrated high-resolution chromatographic separation towards nonpolar and weakly polar organic compounds, including benzene series, n-alkanes, ketone mixtures and trichlorobenzenes...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784365/rapid-detection-of-four-mycotoxins-in-corn-using-a-microfluidics-and-microarray-based-immunoassay-system
#11
Yiqi Chen, Xiangrui Meng, Yunzeng Zhu, Minjie Shen, Ying Lu, Jing Cheng, Youchun Xu
Mycotoxins threaten human health seriously because they usually exist in food, fodder and commodities. In this study, a rapid and sensitive immunoassay system for commonly encountered mycotoxins was established based on microfluidics and protein microarrays. Four mycotoxins (T-2 toxin, aflatoxin B1, ochratoxin A, and zearalenone) can be automatically detected in a custom-made microdevice within 30 min under the assistance of a prototype of the instrument with a fluid control system and an imaging system. Once the microdevices are fabricated, they are small-sized and user-friendly...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784058/fat-suppressed-gadolinium-enhanced-isotropic-high-resolution-3d-gre-t1wi-for-predicting-small-node-metastases-in-patients-with-rectal-cancer
#12
Yan Chen, Xinyue Yang, Ziqiang Wen, Baolan Lu, Xiaojuan Xiao, Bingqi Shen, Shenping Yu
BACKGROUND: To investigate the application value of fat-suppressed gadolinium-enhanced isotropic high-resolution 3D-GRE-T1WI in regional nodes with different short-axis diameter ranges in rectal cancer, especially in nodes ≤5 mm. METHODS: Patients with rectal adenocarcinoma confirmed by postoperative histopathology were included, and all the patients underwent preoperative 3.0 T rectal magnetic resonance imaging (MRI) and total mesorectal excision (TME) within 2 weeks after an MR scan...
May 21, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29784042/neoadjuvant-oxaliplatin-and-capecitabine-combined-with-bevacizumab-plus-radiotherapy-for-locally-advanced-rectal-cancer-results-of-a-single-institute-phase-ii-study
#13
Xin Yu, Qiao-Xuan Wang, Wei-Wei Xiao, Hui Chang, Zhi-Fan Zeng, Zhen-Hai Lu, Xiao-Jun Wu, Gong Chen, Zhi-Zhong Pan, De-Sen Wan, Pei-Rong Ding, Yuan-Hong Gao
BACKGROUND: Neoadjuvant chemoradiotherapy followed by surgery is recommended as the standard of care for locally advanced rectal cancer, reducing local recurrence but not distant metastasis. Intensified systemic therapy is warranted to reduce the risk of distant metastasis. The present study aimed to evaluate the safety and efficacy of neoadjuvant oxaliplatin and capecitabine (XELOX) combined with bevacizumab plus radiotherapy for locally advanced rectal cancer. METHODS: Patients with stages II to III rectal cancer received one cycle of induction chemotherapy and concurrent chemoradiotherapy with XELOX plus bevacizumab...
May 21, 2018: Cancer communications
https://www.readbyqxmd.com/read/29784005/cd8-t-cells-mediate-the-antitumor-activity-of-frankincense-and-myrrh-in-hepatocellular-carcinoma
#14
Chun Xu, Xian Lu, Wei Liu, Anxian Chen, Gang Meng, Hailin Zhang, Binghua Li, Yonghui Zhang, Junhua Wu, Jiwu Wei
BACKGROUND: Tumor-promoting inflammation is an emerging hallmark of cancer, which participates in both cancer progression and immune escape. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer with an extremely poor prognosis. Frankincense and myrrh are anti-inflammation agents commonly used in clinic. The purpose of this study is to investigate whether extract of frankincense and myrrh (FM) downregulates inflammatory microenvironment of HCC and thereby restores antitumor immune responses...
May 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29783823/-phenotypic-and-genotypic-spectra-of-patients-with-glucose-6-phosphate-dehydrogenase-deficiency-gene-known-pathogenic-variants-a-single-center-study
#15
X Chen, L Yang, H J Wang, B B Wu, Y L Lu, X R Dong, W H Zhou
Objective: To analyze the hotspots of known pathogenic disease-causing variants of glucose-6-phosphate dehydrogenase (G6PD) and the phenotype spectrum of neonatal patients with known pathogenic disease-causing variants of G6PD. Methods: The known pathogenic disease-causing variants of G6PD were collected from Human Gene Mutation Database. Screening was performed for these variants among the 7 966 cases (2 357 neonatal, 5 609 non-neonatal) in the database of sequencing at Molecular Diagnosis Center, Children's Hospital of Fudan University...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783675/diffusibility-enhancement-of-rejuvenator-by-epoxidized-soybean-oil-and-its-influence-on-the-performance-of-recycled-hot-mix-asphalt-mixtures
#16
Dongliang Kuang, Yuan Jiao, Zhou Ye, Zaihong Lu, Huaxin Chen, Jianying Yu, Ning Liu
Epoxidized soybean oil (ESO) was employed as a novel penetrant cooperating with a conventional rejuvenator (CR) for the recycling of reclaimed asphalt pavement (RAP). The influence of ESO on the diffusibility and the regenerating effects of CR on RAP were investigated. The diffusibility testing result shows that the diffusibility of CR is enhanced by the addition of ESO because the epoxy group in ESO can facilitate asphaltene dispersion due to its high polarity, which simultaneously reduces the viscosity and improves the fluidity of aged bitumen so as to allow diffusion of the rejuvenator into the aged bitumen...
May 18, 2018: Materials
https://www.readbyqxmd.com/read/29783272/tendon-healing-in-bone-tunnel-after-human-anterior-cruciate-ligament-reconstruction-a-systematic-review-of-histological-results
#17
Hongbin Lu, Can Chen, Shanshan Xie, Yifu Tang, Jin Qu
Most studies concerning to tendon healing and incorporation into bone are mainly based on animal studies due to the invasive nature of the biopsy procedure. The evidence considering tendon graft healing to bone in humans is limited in several case series or case reports, and therefore, it is difficult to understand the healing process. A computerized search using relevant search terms was performed in the PubMed, EMBASE, Scopus, and Cochrane Library databases, as well as a manual search of reference lists. Searches were limited to studies that investigated tendon graft healing to bone by histologic examination after anterior cruciate ligament (ACL) reconstruction with hamstring...
May 21, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29783150/electrophoretic-deposition-of-dexamethasone-loaded-gelatin-nanospheres-chitosan-coating-and-its-dual-function-in-anti-inflammation-and-osteogenesis
#18
Hongfei Qi, Qiang Chen, Hailong Ren, Xianglong Wu, Xianhu Liu, Tingli Lu
Surface modification of metallic implants with bioactive and biodegradable coatings could be a promising approach for bone regeneration. The objective of this study was to prepare chitosan/gelatin nanospheres (GNs) composite coating for the delivery of dexamethasone (DEX). GNs with narrow size distribution and negative surface charge were firstly prepared by a two-step desolvation method. Homogeneous and stable gelatin nanospheres/chitosan (GNs/CTS) composite coatings were formed by electrophoretic deposition (EPD)...
May 18, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29783127/free-acetic-acid-as-the-key-factor-for-the-inhibition-of-hydrogenotrophic-methanogenesis-in-mesophilic-mixed-culture-fermentation
#19
Wei Zhang, Kun Dai, Xiu-Yang Xia, Hua-Jie Wang, Yun Chen, Yong-Ze Lu, Fang Zhang, Raymond Jianxiong Zeng
The inhibition of acetate under acidic pH is an ideal way to reduce methanogenesis in mesophilic mixed culture fermentation (MCF). However, the effects of acetate concentration and acidic pH on methanogenesis remain unclear. Besides, although hydrogenotrophic methanogens can be suitable targets in MCF, they are generally ignored. Therefore, we intentionally enriched hydrogenotrophic methanogens and found that free acetic acid (FAA, x) concentration and specific methanogenic activity (SMA, y) were correlated according to the equation: y = 0...
May 18, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29783115/long-term-trends-in-no-2-columns-related-to-economic-developments-and-air-quality-policies-from-1997-to-2016-in-china
#20
Xiuying Zhang, Wuting Zhang, Xuehe Lu, Xuejun Liu, Dongmei Chen, Lei Liu, Xianjin Huang
This study detected the long-term trends in NO2 concentrations in China from 1997 to 2016 based on the NO2 columns from GOME, SCIAMACHY, and GOME-2A. Both differences in the time-overlapped NO2 columns from GOME vs. SCIAMACHAY and SCIAMACHAY vs. GOME-2A showed seasonal variations, and the annual NO2 columns from GOME were 0.9% higher than those from SCIAMACHY, which exceeded that from GOME-2A by 14%. The long-term trends of the NO2 columns on a provincial scale could be simulated by cubic models (0.60 < R2  < 0...
May 18, 2018: Science of the Total Environment
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