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Lu Chen

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https://www.readbyqxmd.com/read/28545280/-impacts-of-early-metoprolol-intervention-on-connexin-43-and-phosphorylated-connexin-43-expression-in-rabbits-with-experimental-myocardial-infarction
#1
M Zhou, Q Lu, J Q Jiang, Z N Chen, Z G Gong, Z G Li, W W Fu, S F Ding
Objective: To investigate the early intervention effects of metoprolol on connexin 43(Cx43) and phosphorylated Cx43 (p-Cx43) expression in rabbits with post myocardial infarction. Methods: A total of 24 adult male New Zealand white rabbits were divided into sham group (n=6), early treatment group(n=6), routine treatment group(n=6), and myocardial infarction group(n=6) with a randomized block design blocked by weight. Myocardial infarction was induced by left anterior descending coronary artery (LAD) ligation...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28545133/survey-of-health-literacy-level-and-related-influencing-factors-in-military-college-students-in-chongqing-china-a-cross-sectional-analysis
#2
Honghui Rong, Xin Cheng, Jose M Garcia, Ling Zhang, Lu Lu, Jian Fang, Mingshan Le, Peng Hu, Xinlu Dong, Junli Yang, Ya Wang, Ting Luo, Jun Liu, Ji-An Chen
Health literacy (HL) has become an important public health issue and is receiving growing attention. However, the HL levels of military college students in China have never been analyzed. This study aimed to investigate the HL and related associate factors in military college students in Chongqing, China. Data was obtained with the "Chinese Citizen Health Literacy Questionnaire (2012 edition)" from 3183 military college students aged 16-28 years at Chongqing in December 2015. A total score of ≥80 points determined adequate HL, and HL level was defined as the proportion of students who had adequate HL out of the total number of participants...
2017: PloS One
https://www.readbyqxmd.com/read/28544453/black-tungsten-nitride-as-metallic-photocatalyst-for-overall-water-splitting-operable-at-up-to-765-nm
#3
Yu Lei Wang, Ting Nie, Yu Hang Li, Xue Lu Wang, Li Rong Zheng, Ai Ping Chen, Xue Qing Gong, Huagui Yang
Semiconductor photocatalysts are hardly to be employed for overall water splitting beyond 700 nm, owing to both thermodynamic aspects and activation barriers. Metallic materials as photocatalysts are known to overcome this limitation through interband transitions for creating electron-hole pairs, however, the application of metallic photocatalysts for overall water splitting has never been fulfilled. Here we report, for the first time, that the black tungsten nitride can be employed as metallic photocatalyst for overall water splitting at wavelengths of up to 765 nm...
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544087/a-tunable-ionic-diode-based-on-biomimetic-structure-tailorable-nanochannel
#4
Kai Xiao, Lu Chen, Zhen Zhang, Ganhua Xie, Pei Li, Xiang-Yu Kong, Liping Wen, Lei Jiang
In this work, we reported a tunable ionic diode based on biomimetic structure-tailorable nanochannels, with the precise ions transport characteristics from ohmic behaviour to bidirectional rectification as well as the gating properties. The forward/reverse directions of the ionic diode and the degree of rectification can be well regulated by combining the patterned surface charge and the sophisticated structure. This system creates an ideal platform for precise transportation of ions and molecules, and anticipates to have potential applications in analytical sciences...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544069/cd38-enhances-the-proliferation-and-inhibits-the-apoptosis-of-cervical-cancer-cells-by-affecting-the-mitochondria-functions
#5
Shan Liao, Songshu Xiao, Hongxiang Chen, Manying Zhang, Zhifang Chen, Yuehua Long, Lu Gao, Guangchao Zhu, Junyu He, Shuping Peng, Wei Xiong, Zhaoyang Zeng, Zheng Li, Ming Zhou, Xiaoling Li, Jian Ma, Minghua Wu, Juanjuan Xiang, Guiyuan Li, Yanhong Zhou
Cervical cancer is one of the most common malignant tumors in women all over the world. The exact mechanism of occurrence and development of cervical cancer has not been fully elucidated. CD38 is a type II transmembrane glycoprotein, which was found to mediate diverse activities, including signal transduction, cell adhesion, and cyclic ADP-ribose synthesis. Here, we reported that CD38 promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells by affecting the mitochondria functions. We established stable cervical cancer cell lines with CD38 over-expressed...
May 23, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28543175/microrna-141-3p-targets-dapk1-and-inhibits-apoptosis-in-rat-ovarian-granulosa-cells
#6
Dandan Li, Duo Xu, Ying Xu, Lu Chen, Chunjin Li, Xiaowei Dai, Lili Zhang, Lianwen Zheng
The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disorder. MicroRNAs negatively regulate the expression of target genes at posttranscriptional level by binding to the 3' untranslated region of target genes. Our previous study showed that miR-141-3p was dramatically decreased in the ovaries of rat PCOS models. In this study, we aimed to characterize the target of miR-141-3p in rat ovarian granulosa cells. 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay showed that cell viability was dramatically increased when miR-141-3p was overexpressed but was decreased when miR-141-3p was interfered...
May 22, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28542591/molecular-characterization-of-mudskipper-boleophthalmus-pectinirostris-hypoxia-inducible-factor-1%C3%AE-hif-1%C3%AE-and-analysis-of-its-function-in-monocytes-macrophages
#7
Feng Guan, Xin-Jiang Lu, Chang-Hong Li, Jiong Chen
Hypoxia-inducible factor-1α (HIF-1α) plays a critical role in immune and inflammatory responses and is important in controlling a variety of processes in monocytes and macrophages. However, very little information is available about the functions of HIF-1α in fish monocytes/macrophages (MO/MФ). In this study, the cDNA sequence of the mudskipper (Boleophthalmus pectinirostris) HIF-1α gene (BpHIF-1α) was determined. Sequence comparison and phylogenetic tree analysis showed that BpHIF-1α is clustered in the fish HIF-1α tree...
2017: PloS One
https://www.readbyqxmd.com/read/28542515/a-novel-frameshift-mutation-of-smpx-causes-a-rare-form-of-x-linked-nonsyndromic-hearing-loss-in-a-chinese-family
#8
Zhijie Niu, Yong Feng, Lingyun Mei, Jie Sun, Xueping Wang, Juncheng Wang, Zhengmao Hu, Yunpeng Dong, Hongsheng Chen, Chufeng He, Yalan Liu, Xinzhang Cai, Xuezhong Liu, Lu Jiang
X-linked hearing impairment is the rarest form of genetic hearing loss (HL) and represents only a minor fraction of all cases. The aim of this study was to investigate the cause of X-linked inherited sensorineural HL in a four-generation Chinese family. A novel duplication variant (c.217dupA, p.Ile73Asnfs*5) in SMPX was identified by whole-exome sequencing. The frameshift mutation predicted to result in the premature truncation of the SMPX protein was co-segregated with the HL phenotype and was absent in 295 normal controls...
2017: PloS One
https://www.readbyqxmd.com/read/28542400/intracellular-ca2-homeostasis-and-jak1-stat3-pathway-are-involved-in-the-protective-effect-of-propofol-on-bv2-microglia-against-hypoxia-induced-inflammation-and-apoptosis
#9
Yan Lu, Yuechao Gu, Xiaowei Ding, Jiaqiang Wang, Jiawei Chen, Changhong Miao
BACKGROUND: Perioperative hypoxia may induce microglial inflammation and apoptosis, resulting in brain injury. The neuroprotective effect of propofol against hypoxia has been reported, but the underlying mechanisms are far from clear. In this study, we explored whether and how propofol could attenuate microglia BV2 cells from CoCl2-induced hypoxic injury. METHODS: Mouse microglia BV2 cells were pretreated with propofol, and then stimulated with CoCl2. TNF-α level in the culture medium was measured by ELISA kit...
2017: PloS One
https://www.readbyqxmd.com/read/28542312/comparative-transcriptome-profiling-of-a-thermal-resistant-vs-sensitive-silkworm-strain-in-response-to-high-temperature-under-stressful-humidity-condition
#10
Wenfu Xiao, Peng Chen, Jinshu Xiao, La Wang, Taihang Liu, Yunfei Wu, Feifan Dong, Yaming Jiang, Minhui Pan, Youhong Zhang, Cheng Lu
Thermotolerance is important particularly for poikilotherms such as insects. Understanding the mechanisms by which insects respond to high temperatures can provide insights into their adaptation to the environment. Therefore, in this study, we performed a transcriptome analysis of two silkworm strains with significantly different resistance to heat as well as humidity; the thermo-resistant strain 7532 and the thermos-sensitive strain Knobbed. We identified in total 4,944 differentially expressed genes (DEGs) using RNA-Seq...
2017: PloS One
https://www.readbyqxmd.com/read/28542293/identification-and-expression-analysis-of-starch-branching-enzymes-involved-in-starch-synthesis-during-the-development-of-chestnut-castanea-mollissima-blume-cotyledons
#11
Liangke Chen, Dan Lu, Teng Wang, Zhi Li, Yanyan Zhao, Yichen Jiang, Qing Zhang, Qingqin Cao, Kefeng Fang, Yu Xing, Ling Qin
Chinese chestnut (Castanea mollissima Blume) is native to China and distributes widely in arid and semi-arid mountain area with barren soil. As a perennial crop, chestnut is an alternative food source and acts as an important commercial nut tree in China. Starch is the major metabolite in nuts, accounting for 46 ~ 64% of the chestnut dry weight. The accumulation of total starch and amylopectin showed a similar increasing trend during the development of nut. Amylopectin contributed up to 76% of the total starch content at 80 days after pollination (DAP)...
2017: PloS One
https://www.readbyqxmd.com/read/28542282/expression-patterns-of-members-of-the-ethylene-signaling-related-gene-families-in-response-to-dehydration-stresses-in-cassava
#12
Meng Yun Ren, Ren Jun Feng, Hou Rui Shi, Li Fang Lu, Tian Yan Yun, Ming Peng, Xiao Guan, Heng Zhang, Jing Yi Wang, Xi Yan Zhang, Cheng Liang Li, Yan Jun Chen, Peng He, Yin Dong Zhang, Jiang Hui Xie
Drought is the one of the most important environment stresses that restricts crop yield worldwide. Cassava (Manihot esculenta Crantz) is an important food and energy crop that has many desirable traits such as drought, heat and low nutrients tolerance. However, the mechanisms underlying drought tolerance in cassava are unclear. Ethylene signaling pathway, from the upstream receptors to the downstream transcription factors, plays important roles in environmental stress responses during plant growth and development...
2017: PloS One
https://www.readbyqxmd.com/read/28541709/two-dimensional-holey-co3o4-nanosheets-for-high-rate-alkali-ion-batteries-from-rational-synthesis-to-in-situ-probing
#13
Dahong Chen, Lele Peng, Yifei Yuan, Yue Zhu, Zhiwei Fang, Chunshuang Yan, Gang Chen, Reza Shahbazian-Yassar, Jun Lu, Khalil Amine, Guihua Yu
A general template-directed strategy is developed for the controlled synthesis of two-dimensional (2D) Co3O4 nanosheets with unique holey architecture and tunable hole sizes that enable greatly improved alkali-ion storage properties (demonstrated for both Li and Na ion storage). The as-synthesized holey Co3O4 nanosheets with 10 nm holes exhibit excellent reversible capacities of 1324 mAh/g at 0.4 A/g and 566 mAh/g at 0.1 A/g, for Li and Na ion storage, respectively. The improved alkali-ion storage properties are attributed to the unique interconnected holey framework that enables efficient charge/mass transport as well as accommodates volume expansion...
May 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28541024/the-clinical-significance-of-neoadjuvant-chemotherapy-in-improving-the-drug-resistance-of-osteosarcoma
#14
Yongxian Wan, Lili Xu, Naiqiang Zhuo, Jianhua Ge, Ge Chen, Xiao-Bo Lu
No abstract text is available yet for this article.
May 25, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28540953/a-novel-anion-doping-strategy-to-enhance-upconversion-luminescence-in-nagd-moo4-2-yb-3-er-3-nanophosphors
#15
Anming Li, Dekang Xu, Hao Lin, Lu Yao, Shenghong Yang, Yuanzhi Shao, Yueli Zhang, Zhenqiang Chen
We propose a novel and efficient F(-) anion doping strategy for enhancing upconversion luminescence in upconversion nanophosphors. NaGd(MoO4)2:Yb(3+)/Er(3+) nanophosphors doped with different F(-) contents are synthesized hydrothermally. Rietveld refinement results obtained from X-ray diffraction data indicate that the Gd-O bond length decreases and the O-Gd-O bond angle varies with increasing F(-) content, resulting in augmented local crystal field strength and distorted local site symmetry of the dopant lanthanide sites...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28539961/yiqi-huayu-jiedu-decoction-inhibits-the-invasion-and-metastasis-of-gastric-cancer-cells-through-tgf-%C3%AE-smad-pathway
#16
Ting-Ting Wu, Jun Lu, Pei-Qiu Zheng, Shen-Lin Liu, Jian Wu, Wei Sun, Qing-Min Sun, Nai-Xia Ma, Xue-Lian Ding, Min Chen, Xi Zou
Background. Yiqi Huayu Jiedu Decoction (YHJD) can obviously improve the quality of life of those patients with gastric cancer and prolong their survival. Methods. In vitro experiments, we observe YHJD's effect on the cells' proliferation by MTT assay. Cell adhesion assay, wound-healing assay, and Transwell invasion assay serve to detect its influence on cells' adhesion, migration, and invasion, respectively. Inhibitor (10 μM/L of SB431542) and activator (10 ng/mL of TGF-β) of TGF-β/Smad pathway were used to estimate whether YHJD's impact on the biological behavior of gastric cancer cells was related to TGF-β/Smad pathway...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28539884/the-analysis-of-two-bdnf-polymorphisms-g196a-c270t-in-chinese-sporadic-amyotrophic-lateral-sclerosis
#17
Lianping Xu, Danyang Tian, Jiao Li, Lu Chen, Lu Tang, Dongsheng Fan
Amyotrophic lateral sclerosis (ALS) is an ethnically heterogeneous motor neuron disease that results from the selective death of motor neurons in the brain and spinal cord. Brain-derived neurotrophic factor (BDNF) is widely distributed across the central and peripheral nervous systems and plays neurotrophic and other physiological roles in various brain regions. Alterations of neurotrophin availability have been proposed as a pathogenic mechanism underlying ALS neurodegeneration. Several genetic studies have shown a significant association between schizophrenia, Alzheimer's disease, and Parkinson's disease and certain BDNF polymorphisms, specifically G196A (rs6265) and C270T (rs56164415)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28539600/superb-electromagnetic-wave-absorbing-composites-based-on-large-scale-graphene-and-carbon-nanotube-films
#18
Jinsong Li, Weibang Lu, Jonghwan Suhr, Hang Chen, John Q Xiao, Tsu-Wei Chou
Graphene has sparked extensive research interest for its excellent physical properties and its unique potential for application in absorption of electromagnetic waves. However, the processing of stable large-scale graphene and magnetic particles on a micrometer-thick conductive support is a formidable challenge for achieving high reflection loss and impedance matching between the absorber and free space. Herein, a novel and simple approach for the processing of a CNT film-Fe3O4-large scale graphene composite is studied...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539438/discovery-of-a-prefusion-rsv-f-specific-monoclonal-antibody-that-provides-greater-in-vivo-protection-than-the-murine-precursor-of-palivizumab
#19
Min Zhao, Zi-Zheng Zheng, Man Chen, Kayvon Modjarrad, Wei Zhang, Lu-Ting Zhan, Jian-Li Cao, Yong-Peng Sun, Jason S McLellan, Barney S Graham, Ning-Shao Xia
Palivizumab, a humanized murine monoclonal antibody that recognizes antigenic site II on both the prefusion (pre-F) and postfusion (post-F) conformations of the RSV F glycoprotein, is the only prophylactic agent approved for RSV. However, its relatively low neutralizing potency and high cost has limited its use to a restricted population of infants at high risk of severe disease. Previously, we isolated a high potency neutralizing antibody, 5C4, that specifically recognizes antigenic site Ø at the apex of the pre-F trimer...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28539300/-clinical-outcomes-of-intravascular-ultrasound-in-guiding-the-treatment-of-non-left-main-intermediate-coronary-lesions-for-patients-with-acute-coronary-syndrome
#20
Hong-Bin Liang, Qian Guo, Xin-Lu Zhang, Xue-Wei Liu, Yong-Zhen Tang, Wei-Yu Chen, Yu-Qing Hou, Jian-Cheng Xiu
OBJECTIVE: To evaluate the long-term clinical outcomes of intravascular ultrasound(IVUS) in guiding the treatment of non-left main intermediate coronary lesions for patients of acute coronary syndrome (ACS). METHODS: A total of 25 patients with intermediate coronary lesions(stenosis of 40%-70%) confirmed by coronary angiography were performed with IVUS. When MLA≥4 mm(2), we deferred the PCI treatment and performed optimal medical treatment (OMT). The patient were followed up for 12 month...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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