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Jian-Xin Zhou

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https://www.readbyqxmd.com/read/28525480/a-new-entrance-technique-for-c2-pedicle-screw-placement-and-the-use-in-patients-with-atlantoaxial-instability
#1
Jia-Ming Liu, Jian Jiang, Zhi-Li Liu, Xin-Hua Long, Wen-Zhao Chen, Yang Zhou, Song Gao, Lai-Chang He, Shan-Hu Huang
STUDY DESIGN: A prospective study and a technique note. OBJECTIVES: To introduce a new entrance technique for C2 pedicle screw placement and to measure the related linear and angular parameters about the entrance point on computed tomography (CT) images. The safety of this technique for patients with atlantoaxial instability was also evaluated. BACKGROUND DATA: Although earlier studies have introduced different methods for C2 pedicle screw placement, the entry points and the angular parameters may be variable...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28524826/prognostic-analysis-of-102-patients-with-synchronous-colorectal-cancer-and-liver-metastases-treated-with-simultaneous-resection
#2
Ye-Fan Zhang, Rui Mao, Xiao Chen, Jian-Jun Zhao, Xin-Yu Bi, Zhi-Yu Li, Jian-Guo Zhou, Hong Zhao, Zhen Huang, Yong-Kun Sun, Jian-Qiang Cai
BACKGROUND: The liver is the most common site for colorectal cancer (CRC) metastases. Their removal is a critical and challenging aspect of CRC treatment. We investigated the prognosis and risk factors of patients with CRC and liver metastases (CRCLM) who underwent simultaneous resections for both lesions. METHODS: From January 2009 to August 2016, 102 patients with CRCLM received simultaneous resections of CRCLM at our hospital. We retrospectively analyzed their clinical data and analyzed their outcomes...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28514724/sirna-mediated-inactivation-of-her3-improves-the-antitumour-activity-and-sensitivity-of-gefitinib-in-gastric-cancer-cells
#3
Heng-Heng Yuan, Ying-Nan Yang, Jian-Hua Zhou, Yan-Jing Li, Li-Ying Wang, Jun-Wei Qin, Tao Liu, Zhen-Zhen Li, Qing-Xin Zhou, Xiao-Li Wei, Ting-Ting Zhang, Peng Huang, Wen-Jie Zhang, Lei Liu, Xiao-Xue Du, Yu Han
The human EGFR family consists of four type-1 transmembrane tyrosine kinase receptors: HER1 (EGFR, ErbB1), HER2 (Neu, ErbB2), HER3 (ErbB3), and HER4 (ErbB4). HER3 can dimerize with EGFR, HER2 and even c-Met and likely plays a central role in the response to EGFR-targeted therapy. Because HER3 lacks significant kinase activity and cannot be inhibited by tyrosine kinase inhibitors, neutralizing antibodies and alternative inhibitors of HER3 have been sought as cancer therapeutics. Here, we describe the stable suppression of HER3 mRNA and protein using siRNA...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512499/neuroprotective-effect-of-fagopyrum-dibotrys-extract-against-alzheimer-s-disease
#4
Chen Liang, Jian-Ping Yuan, Tao Ding, Lv Yan, Lu Ling, Xin-Fu Zhou, Yue-Qin Zeng
Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. Fagopyrum dibotrys is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of Fagopyrum dibotrys extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of Aβ peptide were evaluated in vitro...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28508666/biotransformation-of-total-coumarins-of-radix-glehniae-by-lecanicillium-attenuatum-w-1-9
#5
Qi Dong, Ye Yuan, Yue Zhou, Yi-Xin Zhang, Jian-Peng Zhang, Hao-Bing Yu, Bing-Hua Jiao, Xiao-Yu Liu, Xiao-Ling Lu
The biotransformation of total coumarins of Radix Glehniae by Lecanicillium attenuatum W-1-9 yielded three new products, lecaniside A (1), lecaniside B (2), and lecaniside C (3). The chemical structures of these metabolites were elucidated based on extensive spectral data, including 2D NMR and HRMS. The hydrogenation, dealkylation, glycosylation, and O-methylation reactions of these metabolites were observed in the present study. In the in vitro assays, compound 1 displayed a little PTP1B inhibitory activity...
May 16, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28504707/regulation-of-mitochondrial-biogenesis-in-erythropoiesis-by-mtorc1-mediated-protein%C3%A2-translation
#6
Xin Liu, Yuannyu Zhang, Min Ni, Hui Cao, Robert A J Signer, Dan Li, Mushan Li, Zhimin Gu, Zeping Hu, Kathryn E Dickerson, Samuel E Weinberg, Navdeep S Chandel, Ralph J DeBerardinis, Feng Zhou, Zhen Shao, Jian Xu
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here we compare the genome-scale proteomic and transcriptomic changes in human primary haematopoietic stem/progenitor cells and erythroid progenitors, and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation. Mitochondrial factors including TFAM and PHB2 are selectively regulated through protein translation during erythroid specification...
May 15, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28502159/lpl-gene-pvu-ii-polymorphism-and-hypertriglyceridemia-a-meta-analysis-involving-1-640-subjects
#7
Yan-Yan Li, Yan-Hong Zhou, Ge Gong, Hong-Yu Geng, Xin-Xing Yang, Xiang-Ming Wang, Chuan-Wei Zhou, Jian Xu, Yun Qian
Background/Aims: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. Methods: A meta-analysis of 1,640 subjects from six individual studies was conducted to better elucidate the potential relationship between the LPL gene Pvu II polymorphism and HT within the Chinese population. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed effect models...
May 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28485318/a-national-multicenter-survey-on-management-of-pain-agitation-and-delirium-in-intensive-care-units-in-china
#8
Jing Wang, Zhi-Yong Peng, Wen-Hai Zhou, Bo Hu, Xin Rao, Jian-Guo Li
BACKGROUND: The management of pain, agitation, and delirium (PAD) in Intensive Care Unit (ICU) is beneficial for patients and makes it widely applied in clinical practice. Previous studies showed that the clinical practice of PAD in ICU was improving; yet relatively little information is available in China. This study aimed to investigate the practice of PAD in ICUs in China. METHODS: A multicenter, nationwide survey was conducted using a clinician-directed questionnaire from September 19 to December 18, 2016...
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28484240/paternal-spatial-training-enhances-offspring-s-cognitive-performance-and-synaptic-plasticity-in-wild-type-but-not-improve-memory-deficit-in-alzheimer-s-mice
#9
Shujuan Zhang, Xiaoguang Li, Zhouyi Wang, Yanchao Liu, Yuan Gao, Lu Tan, Enjie Liu, Qiuzhi Zhou, Cheng Xu, Xin Wang, Gongping Liu, Haote Chen, Jian-Zhi Wang
Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spatial training for one week and assessed the transgenerational effects in the F1 offspring when they were grown to 7-m old. We found that the paternal spatial training significantly enhanced progeny's spatial cognitive performance and synaptic transmission in wild-type mice...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28483616/endovascular-treatment-of-an-unusual-membranous-obstruction-of-the-inferior-vena-cava-in-budd-chiari-syndrome-complicated-by-mural-portal-vein-thrombosis
#10
Wen-Guang Zhang, Dong-Mei Liu, Xin-Wei Han, Jian-Zhuang Ren, Peng-Li Zhou, Zhong-Gao Wang
No abstract text is available yet for this article.
May 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28483578/mhc-ii-but-not-mhc-ii-hepatic-stellate-cells-contribute-to-liver-fibrosis-of-mice-in-infection-with-schistosoma-japonicum
#11
Chun-Lei Zhou, De-Long Kong, Jin-Feng Liu, Zhong-Kui Lu, Hong-Fei Guo, Wei Wang, Jing-Fan Qiu, Xin-Jian Liu, Yong Wang
Hepatic stellate cells (HSCs) are considered as the main effector cells in vitamin A metabolism and liver fibrosis, as well as in hepatic immune regulation. Recently, researches have revealed that HSCs have plasticity and heterogeneity, which depend on their lobular location and whether liver is normal or injured. This research aimed to explore the biological characteristics and heterogeneity of HSCs in mice with Schistosoma japonicum (S. japonicum) infection, and determine the subpopulation of HSCs in pathogenesis of hepatic fibrosis caused by S...
May 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28470483/two-new-compounds-from-schisandra-propinqua-var-propinqua
#12
Miao Liu, Zheng-Xi Hu, Yuan-Qing Luo, Min Zhou, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Jian-Xin Pu, Han-Dong Sun
Schisanpropinoic acid (1), a new bergamotane sesquiterpenoid, and schisanpropinin (2), a new tetrahydrofuran lignan with a rare epoxyethane unit, were identified from the stems and leaves of Schisandra propinqua var. propinqua. Their structures were determined based on comprehensive spectroscopic and mass spectrometric analysis. The absolute configuration of 1 was determined by X-ray analysis. Compounds 1 and 2 were tested for their cytotoxic activity against five human tumor cell lines.
May 3, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28460292/efficient-simultaneous-partial-nitrification-anammox-and-denitrification-snad-system-equipped-with-a-real-time-dissolved-oxygen-do-intelligent-control-system-and-microbial-community-shifts-of-different-substrate-concentrations
#13
Xin Wen, Benzhou Gong, Jian Zhou, Qiang He, Xiaoxia Qing
Simultaneous partial nitrification, anammox and denitrification (SNAD) process was studied in a sequencing batch biofilm reactor (SBBR) fed with synthetic wastewater in a range of 2200 mgN/L ∼ 50 mgN/L. Important was an external real-time precision dissolved oxygen (DO) intelligent control system that consisted of feed forward control system and feedback control system. This DO control system permitted close control of oxygen supply according to influent concentration, effluent quality and other environmental factors in the reactor...
April 21, 2017: Water Research
https://www.readbyqxmd.com/read/28459064/comparison-of-dna-methylation-in-schwann-cells-before-and-after-peripheral-nerve-injury-in-rats
#14
Xian-Hu Zhou, Wei Lin, Yi-Ming Ren, Shen Liu, Bao-You Fan, Zhi-Jian Wei, Gui-Dong Shi, Xin Cheng, Yan Hao, Shi-Qing Feng
This study aims to find the difference of genomewide DNA methylation in Schwann cells (SCs) before and after peripheral nerve system (PNS) injury by Methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq) and seek meaningful differentially methylated genes related to repairment of injured PNS. SCs harvested from sciatic nerve were named as activated Schwann cells (ASCs), and the ones harvested from brachial plexus were named as normal Schwann cells (NSCs). Genomic DNA of ASCs and NSCs were isolated and MeDIP-Seq was conducted...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28455982/comparisons-of-short-term-and-survival-outcomes-of-laparoscopy-assisted-versus-open-total-gastrectomy-for-gastric-cancer-patients
#15
Xin-Zu Chen, Shao-Yong Wang, Yin-Su Wang, Zi-Han Jiang, Wei-Han Zhang, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Meng Qiu, Hong-Feng Gou, Zong-Guang Zhou, Jian-Kun Hu
OBJECTIVES: The safety and surgical oncology of laparoscopy-assisted total gastrectomy (LATG) remain inconclusive and challenging. This study aimed to compare the short-term and long-term outcomes between LATG and open total gastrectomy (OTG) procedures. RESULTS: In the all-included analyses, there were 69 patients in the LATG group and 268 in the OTG group. LATG was as safe as OTG without increasing postoperative morbidity and mortality. Stage imbalance might introduce differences in the numbers of harvested lymph nodes in LATG (34...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454595/expenditure-and-financial-burden-for-the-diagnosis-and-treatment-of-colorectal-cancer-in-china-a-hospital-based-multicenter-cross-sectional-survey
#16
Hui-Yao Huang, Ju-Fang Shi, Lan-Wei Guo, Ya-Na Bai, Xian-Zhen Liao, Guo-Xiang Liu, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Xin-Yu Zhu, Le Wang, Bing-Bing Song, Ling-Bin Du, Lin Zhu, Ji-Yong Gong, Qi Zhou, Yu-Qin Liu, Rong Cao, Ling Mai, Li Lan, Xiao-Hua Sun, Ying Ren, Jin-Yi Zhou, Yuan-Zheng Wang, Xiao Qi, Pei-An Lou, Dian Shi, Ni Li, Kai Zhang, Jie He, Min Dai
BACKGROUND: The increasing prevalence of colorectal cancer (CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China. METHODS: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014...
April 28, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28454092/hoxb7-promotes-tumor-progression-via-bfgf-induced-activation-of-mapk-erk-pathway-and-indicated-poor-prognosis-in-hepatocellular-carcinoma
#17
Wei-Min Wang, Yang Xu, Yao-Hui Wang, Hai-Xiang Sun, Yun-Fan Sun, Yi-Feng He, Qing-Feng Zhu, Bo Hu, Xin Zhang, Jing-Lin Xia, Shuang-Jian Qiu, Jian Zhou, Xin-Rong Yang, Jia Fan
The homeobox-containing gene HOXB7 plays an important role in the pathogenesis and progression of many cancers, yet its role in hepatocellular carcinoma (HCC) remains unclear. This study comprehensively analyzed the expression and clinical significance of HOXB7 in HCC and explored its potential mechanism in tumor progression. We found HOXB7 was highly expressed in HCC cell lines with highly metastatic potential and cancerous tissues from patients with tumor recurrence. The abilities of proliferation, migration, and invasion were notably decreased by depletion of HOXB7, and were enhanced by its enforced expression in vitro...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453574/social-defeat-stress-causes-depression-like-behavior-with-metabolite-changes-in-the-prefrontal-cortex-of-rats
#18
Yi-Yun Liu, Xin-Yu Zhou, Li-Ning Yang, Hai-Yang Wang, Yu-Qing Zhang, Jun-Cai Pu, Lan-Xiang Liu, Si-Wen Gui, Li Zeng, Jian-Jun Chen, Chan-Juan Zhou, Peng Xie
Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass spectrometry. Within the first week after the social defeat procedure, the sucrose preference test (SPT), open field test (OFT), elevated plus maze (EPM) and forced swim test (FST) were conducted to examine the depressive-like and anxiety-like behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/28451339/surface-engineering-to-achieve-organic-ternary-memory-with-a-high-device-yield-and-improved-performance
#19
Xiang Hou, Xin Xiao, Qian-Hao Zhou, Xue-Feng Cheng, Jing-Hui He, Qing-Feng Xu, Hua Li, Na-Jun Li, Dong-Yun Chen, Jian-Mei Lu
Squaraine molecules deposited on indium tin oxide (ITO) substrates modified with phosphonic acids crystalize more orderly than do those on untreated ITO. The as-fabricated electro-resistive memories show the highest ternary device yield observed to date (82%), a narrower switching voltage distribution, and better retention as well as resistance uniformity.
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28443566/atypical-chemokine-receptor-1-polymorphism-can-not-affect-susceptibility-to-hepatitis-c-virus
#20
Shu Ting Zhang, Ming Shi, Lin Nan Shao, Shi Hang Zhou, Wei Jian Yu, Mei Chen, Nan Xiao, Ying Duan, Ling Zi Pan, Ni Wang, Wen Qian Song, Yue Xin Xia, Li Zhang, Ning Qi, Ming Liu
BACKGROUND: Hepatitis C virus (HCV) has infected 130 to 150 million individuals globally. A significant number of chronically infected patients will develop liver cirrhosis, hepatocellular cancer and liver failure. Atypical Chemokine Receptor 1 (ACKR1) has become the focus because of its diverse roles in diseases. However, little is known regarding the association of ACKR1 polymorphism with the susceptibility to HCV. AIMS: The purpose of the present study is to determine the association of the ACKR1 polymorphisms (rs12075) with HCV susceptibility...
April 6, 2017: Balkan Medical Journal
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