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Jian-Xin Zhou

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https://www.readbyqxmd.com/read/29448851/salvage-tigecycline-in-high-risk-febrile-neutropenic-patients-with-hematological-malignancies-a-prospective-multicenter-study
#1
Xin-Ping Zhou, Xiu-Jin Ye, Jian-Ping Shen, Jian-Ping Lan, Hui-Fang Jiang, Jin Zhang, Xue-Jin Zhang, Li Li, Shen-Xian Qian, Hong-Yan Tong
The purpose of this prospective, multi-center study was to examine the efficacy and safety of tigecycline as empirical treatment in neutropenic patients with hematological malignancies who failed to respond to first-line antibiotics. A total of 125 patients with persistent fever (>72 h) despite first-line antibiotics received empirical treatment with tigecycline (loading dose of 100 mg, followed by 50 mg every 12 h). The use of other antimicrobial agents was not restricted. Treatment success rate was 68...
February 16, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29445125/pin1-impairs-microrna-biogenesis-by-mediating-conformation-change-of-xpo5-in-hepatocellular-carcinoma
#2
Jiao Li, Wenchen Pu, Hui-Lung Sun, Jian-Kang Zhou, Xin Fan, Yuanyuan Zheng, Juan He, Xuesha Liu, Zhichu Xia, Lunxu Liu, Yu-Quan Wei, Yong Peng
MicroRNA (miRNA) dysregulation is associated with the tumorigenesis and development of numerous human cancers. The defect in miRNA biogenesis is the main cause of miRNA dysregulation. We previously demonstrated that ERK-induced phosphorylation of XPO5 followed by peptidyl-prolyl cis/trans isomerase Pin1-mediated isomerization downregulates miRNA expression and contributes to hepatocellular carcinoma (HCC) development. However, how Pin1 precisely regulates miRNA biogenesis in HCC remains elusive. Here we reveal that Pin1 has a pivotal role in the miRNA maturation process by modulating phosphorylated Serine-Proline (pS-P) motif of XPO5 in a phosphorylation-dependent manner...
February 14, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29444644/use-of-esophageal-balloon-pressure-volume-curve-analysis-to-determine-esophageal-wall-elastance-and-calibrate-raw-esophageal-pressure-a-bench-experiment-and-clinical-study
#3
Xiu-Mei Sun, Guang-Qiang Chen, Hua-Wei Huang, Xuan He, Yan-Lin Yang, Zhong-Hua Shi, Ming Xu, Jian-Xin Zhou
BACKGROUND: Accurate measurement of esophageal pressure (Pes) depends on proper filling of the balloon. Esophageal wall elastance (Ees) may also influence the measurement. We examined the estimation of balloon-surrounding elastance in a bench model and investigated a simplified calibrating procedure of Pes in a balloon with relatively small volume. METHODS: The Cooper balloon catheter (geometric volume of 2.8 ml) was used in the present study. The balloon was progressively inflated in different gas-tight glass chambers with different inner volumes...
February 14, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29433675/plant-natural-product-plumbagin-presents-potent-inhibitory-effect-on-human-cytochrome-p450-2j2-enzyme
#4
Jian Lu, Daozhi Liu, Xiaojing Zhou, Ang Chen, Zhenran Jiang, Xiyun Ye, Mingyao Liu, Xin Wang
BACKGROUND: Cytochrome P450 2J2 (CYP2J2) is not only highly expressed in many kinds of human tumors, but also promotes tumor cell growth via regulating the metabolism of arachidonic acids. CYP2J2 inhibitors can significantly reduce proliferation, migration and promote apoptosis of tumor cells by inhibiting epoxyeicosatrienoic acids (EETs) biosynthesis. Therefore screening CYP2J2 inhibitors is a significant way for the development of anti-cancer drug. PURPOSE: The aim of this study was to identify a new CYP2J2 inhibitor from fifty natural compounds obtained from plants...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29424259/increased-oxidative-damage-of-rna-in-liver-injury-caused-by%C3%A2-hepatitis-b-virus-hbv-infection
#5
Xin-Min Xu, Xiao-Yang Zhou, Xiang-Yu Li, Jie Guo, Hui-Zhu Wang, Yue Li, Cheng-Cheng Yang, Teng-Hui Liu, Jian-Ping Cai
To evaluate the urinary levels of 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) in liver injury patients with hepatitis B virus (HBV) infection and to explore the relationship between urinary 8-oxo-dGsn or 8-oxo-Gsn and degree of liver damage. We enrolled 138 liver injury patients with HBV infection and 169 age and sex matched healthy controls in this study. A sensitive and accurate isotope-diluted LC-MS/MS method was used to measure the urinary levels of 8-oxo-Gsn and 8-oxo-dGsn...
February 9, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29422068/early-evaluation-of-radiation-induced-parotid-damage-in-patients-with-nasopharyngeal-carcinoma-by-t2-mapping-and-mdixon-quant-imaging-initial-findings
#6
Nan Zhou, Chen Chu, Xin Dou, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
BACKGROUND: Radiation-induced parotid damage is a common complication in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy to head and neck region, which severely reduce the life quality of those patients. The aim of this study was to early evaluate the changes of irradiated parotid glands with T2 mapping and mDIXON Quant imaging. METHODS: Forty-one patients with NPC underwent conventional magnetic resonance imaging for nasopharynx and neck, and T2 mapping and mDIXON Quant imaging for bilateral parotid glands within 2 weeks before radiotherapy (pre-RT), 5 weeks after the beginning of radiotherapy (mid-RT), and 4 weeks after radiotherapy (post-RT)...
February 8, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29420593/preconception-paternal-bisphenol-a-exposure-induces-sex-specific-anxiety-and-depression-behaviors-in-adult-rats
#7
Ying Fan, Chong Tian, Qilin Liu, Xianyue Zhen, Hui Zhang, Liangneng Zhou, Taibiao Li, Yun Zhang, Shibin Ding, Dongliang He, Xin Jin, Jian Liu, Beibei Zhang, Nannan Wu, Anne Manyande, Maoshu Zhu
Bisphenol A (BPA), an environmental endocrine-disrupting compound, has drawn a great attention for its adverse effect on behavioral development. Maternal exposure to this compound has been reported to induce anxiety and depression in offspring, but the effect of its paternal exposure is rarely discussed. This study investigated whether preconception paternal BPA exposure can affect the emotions of male rats and their offspring. Eighteen adult male rats (F0) received either a vehicle or 50 μg/kg/day BPA diet for 21 weeks and were then mated with non-exposed females to produce offspring (F1)...
2018: PloS One
https://www.readbyqxmd.com/read/29420221/adjuvant-transarterial-chemoembolization-for-hbv-related-hepatocellular-carcinoma-after-resection-a-randomized-controlled-study
#8
Jian Zhou, Zheng Wang, Zhenggang Ren, Yi Chen, Jie Hu, Guo-Huan Yang, Lei Yu, Xin-Rong Yang, Ao Huang, Xin Zhang, Shao Lai Zhou, Hui-Chuan Sun, Yan Hong Wang, Ning Ling Ge, Xiao-Yu Xu, Zhaoyou Tang, Wan Yee Lau, Jia Fan, Jiping Wang
PURPOSE: The survival of patients with hepatocellular carcinoma (HCC) recurrence after curative resection are usually poor. We sought to evaluate the safety and efficacy of adjuvant transarterial chemoembolization (TACE) in HBV-related HCC patients with an intermediate (a single tumor larger than 5 cm without microvascular invasion) or high risk (a single tumor with microvascular invasion, or two or three tumors) of recurrence. EXPERIMENTAL DESIGN: In this randomized phase 3 trial, 280 eligible patients were assigned to adjuvant TACE (n=140) or no adjuvant treatment (control; n = 140) groups...
February 2, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29409972/inhibition-of-dipeptidyl-peptidase-iv-prevents-high-fat-diet-induced-liver-cancer-angiogenesis-by-downregulating-chemokine-ligand-2
#9
Chen-Jie Qin, Ling-Hao Zhao, Xu Zhou, Hui-Lu Zhang, Wen Wen, Liang Tang, Min Zeng, Ming-Da Wang, Gong-Bo Fu, Shuai Huang, Wei-Jian Huang, Yuan Yang, Zhi-Jun Bao, Wei-Ping Zhou, Hong-Yang Wang, He-Xin Yan
Obesity is a major risk factor for hepatocellular carcinoma (HCC) and is typically accompanied by higher levels of serum dipeptidyl peptidase 4 (DPP4). However, the role of DPP4 in obesity-promoted HCC is unclear. Here, we found that consumption of a high-fat diet (HFD) promoted HCC cell proliferation and metastasis and led to poor survival in a carcinogen-induced model of HCC in rats. Notably, genetic ablation of DPP4 or treatment with a DPP4 inhibitor (vildagliptin) prevented HFD-induced HCC. Moreover, HFD-induced DPP4 activity facilitated angiogenesis and cancer cell metastasis in vitro and in vivo, and vildagliptin prevented tumor progression by mediating the pro-angiogenic role of chemokine ligand 2 (CCL2)...
January 31, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29395708/successful-treatment-of-type-1-cryoglobulinemic-vasculitis-with-cardiac-involvement
#10
Xin-Xin Cao, Zhuang Tian, Lu Lin, Jian Sun, Wei Su, Dao-Bin Zhou, Jian Li
Cryoglobulinemic vasculitis is a rare and frequently fatal type of myocarditis. Cardiac manifestations in type 1 cryoglobulinemic vasculitis have never been reported to our knowledge. We report a rare case of type 1 cryoglobulinemic vasculitis with cardiac involvement in a patient who experienced progressive heart failure during the diagnosis. The diagnosis was made by the presence of cryoglobulins and endomyocardial biopsy results. After bortezomib-containing treatments, plasma cryoglobulin levels returned to normal, and the patient's clinical condition gradually improved...
December 28, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29383189/clinicopathological-analysis-of-hoxd4-expression-in-diffuse-gliomas-and-its-correlation-with-idh-mutations-and-1p-19q-co-deletion
#11
Xin-Wei Zhao, Yun-Bo Zhan, Jian-Ji Bao, Jin-Qiao Zhou, Feng-Jiang Zhang, Yu Bin, Ya-Hui Bai, Yan-Min Wang, Zhen-Yu Zhang, Xian-Zhi Liu
Backgrounds: HOX (homologous box) is known as the dominant gene of vertebrate growth and cell differentiation. Abnormal expression of HOX gene in various tumors has attracted the attention of scholars. As a component of HOX clusters, HOXD4 plays a controversial role in the tumorigenesis of central nervous system. Results: The data demonstrated that and the results demonstrated that HOXD4 was overexpressed in glioma tissues compared to that of normal brain tissues...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29381806/targeting-pin1-by-inhibitor-api-1-regulates-microrna-biogenesis-and-suppresses-hepatocellular-carcinoma-development
#12
Wenchen Pu, Jiao Li, Yuanyuan Zheng, Xianyan Shen, Xin Fan, Jian-Kang Zhou, Juan He, Yulan Deng, Xuesha Liu, Chun Wang, Shengyong Yang, Qiang Chen, Lunxu Liu, Guolin Zhang, Yu-Quan Wei, Yong Peng
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, but there are few effective treatments. Aberrant microRNA (miRNA) biogenesis is correlated with HCC development. We previously demonstrated that prolyl isomerase Pin1 participates in miRNA biogenesis and is a potential HCC treatment target. However, how Pin1 modulates miRNA biogenesis remains obscure. Here, we present in vivo evidence that Pin1 overexpression is directly linked to the development of HCC. Administration with Pin1 inhibitor API-1, a novel and specific small molecule targeting Pin1 PPIase domain and inhibiting Pin1 cis-trans isomerizing activity, suppresses in vitro cell proliferation and migration of HCC cells...
January 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29379155/a-genome-for-gnetophytes-and-early-evolution-of-seed-plants
#13
Tao Wan, Zhi-Ming Liu, Ling-Fei Li, Andrew R Leitch, Ilia J Leitch, Rolf Lohaus, Zhong-Jian Liu, Hai-Ping Xin, Yan-Bing Gong, Yang Liu, Wen-Cai Wang, Ling-Yun Chen, Yong Yang, Laura J Kelly, Ji Yang, Jin-Ling Huang, Zhen Li, Ping Liu, Li Zhang, Hong-Mei Liu, Hui Wang, Shu-Han Deng, Meng Liu, Ji Li, Lu Ma, Yan Liu, Yang Lei, Wei Xu, Ling-Qing Wu, Fan Liu, Qian Ma, Xin-Ran Yu, Zhi Jiang, Guo-Qiang Zhang, Shao-Hua Li, Rui-Qiang Li, Shou-Zhou Zhang, Qing-Feng Wang, Yves Van de Peer, Jin-Bo Zhang, Xiao-Ming Wang
Gnetophytes are an enigmatic gymnosperm lineage comprising three genera, Gnetum, Welwitschia and Ephedra, which are morphologically distinct from all other seed plants. Their distinctiveness has triggered much debate as to their origin, evolution and phylogenetic placement among seed plants. To increase our understanding of the evolution of gnetophytes, and their relation to other seed plants, we report here a high-quality draft genome sequence for Gnetum montanum, the first for any gnetophyte. By using a novel genome assembly strategy to deal with high levels of heterozygosity, we assembled >4 Gb of sequence encoding 27,491 protein-coding genes...
January 29, 2018: Nature Plants
https://www.readbyqxmd.com/read/29374605/an-experimental-study-on-repeated-brief-ischemia-in-promoting-sciatic-nerve-repair-and-regeneration-in-rats
#14
Xiao-Bin Zhou, De-Xin Zou, Wei Gu, Dong Wang, Jian-Shu Feng, Jiang-Yong Wang, Jun-Lin Zhou
BACKGROUND: Researches have shown that ischemic preconditioning reduced the severity of ischemia-reperfusion injury in brain in rats, we have a hypothesis that repeated brief ischemia has positive effects on peripheral nerve damage. AIM: This study was conducted to investigate the potential protective effects of repeated brief ischemia on peripheral nerve regeneration using a rat model of experimental sciatic nerve transection injury. METHOD: Treatment groups (group A-D) received repeated brief ischemia every one day/two days/three days/7 days...
January 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29374055/circulating-tumor-cells-with-stem-like-phenotypes-for-diagnosis-prognosis-and-therapeutic-response-evaluation-in-hepatocellular-carcinoma
#15
Jia Fan, Wei Guo, Yun-Fan Sun, Minna Shen, Xiao-Lu Ma, Jiong Wu, Chunyan Zhang, Yan Zhou, Yang Xu, Bo Hu, Min Zhang, Gang Wang, Wei-Qin Chen, Lin Guo, Renquan Lu, Chao-Hui Zhou, Xin Zhang, Ying-Hong Shi, Shuang-Jian Qiu, Bai-Shen Pan, Ya Cao, Jian Zhou, Xin-Rong Yang
PURPOSE: In present study, we assessed the clinical value of circulating tumor cells (CTCs) with stem-like phenotypes for diagnosis, prognosis and surveillance in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) by an optimized QPCR-based detection platform. EXPERIMENTAL DESIGN: Differing subsets of CTCs were investigated, and a multimarker diagnostic CTC panel was constructed in a multicenter-patient study with independent validation (total n=1006), including healthy individuals, patients with chronic hepatitis B infection (CHB), liver cirrhosis (LC), benign hepatic lesion (BHL) and HBV-related HCC, with area under the receiver operating characteristic curve (AUC-ROC) reflecting diagnostic accuracy...
January 26, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29367041/clinicopathological-characteristics-and-prognostic-factors-of-remnant-gastric-cancer-a-single-center-retrospective-analysis-of-90-patients
#16
Xiao-Hai Song, Kai Liu, Li-Fei Sun, Xiao-Long Chen, Lin-Yong Zhao, Wei-Han Zhang, Xin-Zu Chen, Kun Yang, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou, Jian-Kun Hu
BACKGROUND: The prognosis of remnant gastric cancer (RGC) is significantly poor. However, the mechanism and some clinical features of RGC have not been fully understood and are still under debate. MATERIALS AND METHODS: From January 2000 to January 2014, 90 RGC patients were enrolled in this retrospective study. Patients were divided into two groups according to primary disease. Clinicopathological features and survival outcomes were compared between two groups...
January 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29355860/interface-engineered-in-situ-anchoring-of-co9s8-nanoparticles-into-a-multiple-doped-carbon-matrix-highly-efficient-zinc-air-batteries
#17
Yang Li, Wei Zhou, Juncai Dong, Yun Luo, Pengfei An, Juan Liu, Xin Wu, Guilan Xu, Huabin Zhang, Jian Zhang
Interface modification is an effective and promising route for developing functional electrocatalysts. However, researchers have not created a reliable method to optimize the interfaces of components existing in electrocatalysts, although it is very crucial for the technological development of high-performance electrodes. Here, we develop a strategy aiming at the in situ anchorage of Co9S8 nanoparticles into a nitrogen (N), sulfur (S) co-implanted three-dimensional carbon matrix (Co9S8@NSCM) as a highly active and durable nonprecious metal electrocatalyst for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in alkaline medium...
January 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29343834/newly-discovered-late-triassic-baqing-eclogite-in-central-tibet-indicates-an-anticlockwise-west-east-qiangtang-collision
#18
Yu-Xiu Zhang, Xin Jin, Kai-Jun Zhang, Wei-Dong Sun, Jian-Ming Liu, Xiao-Yao Zhou, Li-Long Yan
The Triassic eclogite-bearing central Qiangtang metamorphic belt (CQMB) in the northern Tibetan Plateau has been debated whether it is a metamorphic core complex underthrust from the Jinsha Paleo-Tethys or an in-situ Shuanghu suture. The CQMB is thus a key issue to elucidate the crustal architecture of the northern Tibetan Plateau, the tectonics of the eastern Tethys, and the petrogenesis of Cenozoic high-K magmatism. We here report the newly discovered Baqing eclogite along the eastern extension of the CQMB near the Baqing town, central Tibet...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338816/fabrication-of-isoniazid-rifampicin-poly-l-lactic-acid-donut-shaped-implants-via-three-dimensional-printing-technique
#19
Gui Wu, Wei Gang Wu, Jian Bo Zhou, Qi Xin Zheng
Objective To investigate the possibility of manufacturing dual-drug loaded isoniazid/rifampicin/poly L-lactic acid (PLLA) implant with donut-shaped structure via three-dimensional (3D) printing technique and study the drug release characteristic and biocompatibility of the implant in vitro.Methods PLLA was crushed into particles with diameters around 75-100 μm.Isoniazid and rifampicin bulk drugs were dissolved into the organic dissolvent respectively to be the binding liquid.The 3D printing machine fabricated the donut-shaped implant via binding the PLLA powder layer by layer...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29330507/uncovering-the-anticancer-mechanism-of-compound-kushen-injection-against-hcc-by-integrating-quantitative-analysis-network-analysis-and-experimental-validation
#20
Li Gao, Ke-Xin Wang, Yu-Zhi Zhou, Jian-Song Fang, Xue-Mei Qin, Guan-Hua Du
Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed that CKI can inhibit the proliferation of hepatocellular carcinoma (HCC) cell lines, the active compounds, potential targets and pathways involved in these effects have not been systematically investigated. Here, we proposed a novel idea of "main active compound-based network pharmacology" to explore the anti-cancer mechanism of CKI...
January 12, 2018: Scientific Reports
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