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https://www.readbyqxmd.com/read/27912969/triterpenoid-saponins-with-anti-inflammatory-activities-from-ilex-pubescens-roots
#1
Peng Wu, Hui Gao, Jian-Xin Liu, Liang Liu, Hua Zhou, Zhong-Qiu Liu
Seven triterpenoid saponins, named ilexsaponin I-O, along with twelve known ones, were isolated from the roots of Ilex pubescens. The structures of all compounds were elucidated by use of extensive spectroscopic methods (IR, HR-ESI-MS, and 1D and 2D NMR). Sugar residues obtained after acid hydrolysis were identified by TLC and HPLC. The in vitro anti-inflammatory effects of the triterpenoid saponins were also evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264...
November 29, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27906388/correction-molecular-stacking-dependent-phosphorescence-fluorescence-dual-emission-in-a-single-luminophore-for-self-recoverable-mechanoconversion-of-multicolor-luminescence
#2
Hongwei Wu, Cheng Hang, Xin Li, Liyuan Yin, Mingjie Zhu, Jian Zhang, Yunyun Zhou, Hans Ågren, Qing Zhang, Liangliang Zhu
Correction for 'Molecular stacking dependent phosphorescence-fluorescence dual emission in a single luminophore for self-recoverable mechanoconversion of multicolor luminescence', Chem. Commun., 2016, DOI: .
December 1, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27894156/mitral-valve-repair-using-an-autologous-pericardial-strip-in-infants-and-young-children
#3
Li-Xin Liu, Jian-Feng Zhang, Wei-Xian Xu, Xiao-Bo Zhao, Wei-Li Zhou, Lei Xi, Guo-Wei He
We have modified the mitral repair technique in infants and small children by using autologous pericardial strips to treat mitral regurgitation resulting from a dilated mitral annulus. Our results demonstrate that this technique maintains stability and flexibility of the mitral annulus and decreases the risk of mitral stenosis.
November 28, 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27889799/a-polymorphism-in-the-promoter-region-of-pd-l1-serves-as-a-binding-site-for-sp1-and-is-associated-with-pd-l1-overexpression-and-increased-occurrence-of-gastric-cancer
#4
Li-Hua Tao, Xin-Ru Zhou, Fu-Chao Li, Qi Chen, Fan-Yi Meng, Yong Mao, Rui Li, Dong Hua, Hong-Jian Zhang, Wei-Peng Wang, Wei-Chang Chen
PD-L1 is a member of the B7 family co-inhibitory molecules and plays a critical role in tumor immune escape. In this study, we found a polymorphism rs10815225 in the PD-L1 promoter region was significantly associated with the occurrence of gastric cancer. The GG homozygous frequency was higher in the cancer patients than that in the precancerous lesions, which was higher than that in the health controls. This polymorphism locates in the binding-site of Sp1 transcription factor (SP1). The expression level of PD-L1 mRNA in the GG homozygous cancer patients was apparently higher than that in the GC heterozygotes...
November 26, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27885760/haploidentical-hematopoietic-stem-cell-transplantation-for-a-case-with-x-linked-chronic-granulomatous-disease
#5
Ling Zhou, Lu-Jia Dong, Zhi-Yong Gao, Xin-Jian Yu, Dao-Pei Lu
CGD is a rare primary immunodeficiency with high mortality rates when treated conventionally, especially for the X-chromosome-linked form. HSCT is the only curative therapy for CGD; however, haploidentical transplantation in CGD is rare. Here, we report a case of X-linked CGD treated successfully by haploidentical HSCT. The patient showed a positive result with full donor chimerism, good quality of life, and the absence of recurrent infectious diseases at follow-up (68 months). Thus, haploidentical HSCT may serve as an acceptable treatment approach for patients who have CGD, but no HLA-matched related or unrelated donor...
November 25, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27880930/lactate-dehydrogenase-is-a-prognostic-indicator-in-patients-with-hepatocellular-carcinoma-treated-by-sorafenib-results-from-the-real-life-practice-in-hbv-endemic-area
#6
Mu-Xing Li, Hong Zhao, Xin-Yu Bi, Zhi-Yu Li, Xue-Song Yao, Huai Li, Zhen Huang, Yue Han, Jian-Guo Zhou, Jian-Jun Zhao, Ye-Fan Zhang, Dong-Bin Zhao, Jian-Qiang Cai
PURPOSE: Lactate dehydrogenase (LDH), which was an indirect marker of hypoxia, was a potentially prognostic factor in several malignancies. There is a lack of evidence about the prognostic value of serum LDH level in patients with hepatocellular carcinoma (HCC) receiving sorafenib treatment from hepatitis B virus endemic areas. MATERIALS AND METHODS: A total of 119 HBV-related HCC patients treated by sorafenib from a Chinese center were included into the study. They were categorized into 2 groups according to the cut-off value of pre-treatment LDH, which was determined by the time dependent receiver operating characteristics (ROC) curve for the overall survival...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27871309/draft-genome-of-the-living-fossil-ginkgo-biloba
#7
Rui Guan, Yunpeng Zhao, He Zhang, Guangyi Fan, Xin Liu, Wenbin Zhou, Chengcheng Shi, Jiahao Wang, Weiqing Liu, Xinming Liang, Yuanyuan Fu, Kailong Ma, Lijun Zhao, Fumin Zhang, Zuhong Lu, Simon Ming-Yuen Lee, Xun Xu, Jian Wang, Huanming Yang, Chengxin Fu, Song Ge, Wenbin Chen
BACKGROUND: Ginkgo biloba L. (Ginkgoaceae) is one of the most distinctive plants. It possesses a suite of fascinating characteristics including a large genome, outstanding resistance/tolerance to abiotic and biotic stresses, and dioecious reproduction, making it an ideal model species for biological studies. However, the lack of a high-quality genome sequence has been an impediment to our understanding of its biology and evolution. FINDINGS: The 10.61 Gb genome sequence containing 41,840 annotated genes was assembled in the present study...
November 21, 2016: GigaScience
https://www.readbyqxmd.com/read/27867545/an-evaluation-study-of-research-efficiency-of-the-guangzhou-institute-of-respiratory-diseases-based-on-malmquist-index
#8
Jian-Feng Liao, Juan Wang, Liang Liang, Yong-Ding Wu, Mei-Juan Huang, Tian-Qiang Liu, Lin Zhou, Xin-Wang Wang
BACKGROUND: This study aimed to analyze the dynamic changes of the scientific research innovation efficiency of Guangzhou Institute of Respiratory Diseases (GIRD) during the year 2009-2013 to explore the reason for these changes and give some suggestions on how to improve the overall efficiency of the Institute. METHODS: The panel data used in this study were taken from 19 research teams of GIRD during 2009 to 2013. Data envelopment analysis (DEA) based on Malmquist index (MI) was used to analyze the performance of each research team in terms of productivity changes over time...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27858011/modulation-of-the-relaxation-dynamics-of-linear-shaped-tetranuclear-rare-earth-clusters-through-utilizing-different-solvents
#9
Ru-Xia Zhang, Yi-Xin Chang, Hai-Yun Shen, Wen-Min Wang, Xiao-Pu Zhou, Ni-Ni Wang, Jian-Zhong Cui, Hong-Ling Gao
Nine new tetranuclear centrosymmetric linear complexes, [RE4(dbm)8L2(DMF)2]·nCH2Cl2·mC2H3N (RE = Y (1), Tb (2), Dy (3), Ho (4), Er (5), Lu (6)) and [RE4(dbm)8L2(C2H5OH)2]·nCH3CN (RE = Tb (7), Dy (8), Ho (9)) (HL = 2-[(2-(hydroxyimino)propanehydrazide)methyl]-8-hydroxyquinoline and dbm = 1,3-diphenyl-1,3-propanedione) have been synthesized. Complexes 1-9 are tetranuclear complexes. Magnetic studies reveal that both Dy(III)-based complexes (3 and 8) exhibit single-molecule magnet (SMM) behavior under a zero dc field...
November 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27852713/effects-of-increased-positive-end-expiratory-pressure-on-intracranial-pressure-in-acute-respiratory-distress-syndrome-a-protocol-of-a-prospective-physiological-study
#10
Han Chen, Ming Xu, Yan-Lin Yang, Kai Chen, Jing-Qing Xu, Ying-Rui Zhang, Rong-Guo Yu, Jian-Xin Zhou
INTRODUCTION: There are concerns that the use of positive end-expiratory pressure (PEEP) in patients with brain injury may potentially elevate intracranial pressure (ICP). However, the transmission of PEEP into the thoracic cavity depends on the properties of the lungs and the chest wall. When chest wall elastance is high, PEEP can significantly increase pleural pressure. In the present study, we investigate the different effects of PEEP on the pleural pressure and ICP in different respiratory mechanics...
November 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852284/prognostic-value-and-predictive-threshold-of-tumor-volume-for-patients-with-locally-advanced-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy
#11
Yu-Xiang He, Ying Wang, Peng-Fei Cao, Lin Shen, Ya-Jie Zhao, Zi-Jian Zhang, Deng-Ming Chen, Tu-Bao Yang, Xin-Qiong Huang, Zhou Qin, You-Yi Dai, Liang-Fang Shen
BACKGROUND: Gross target volume of primary tumor (GTV-P) is very important for the prognosis prediction of patients with nasopharyngeal carcinoma (NPC), but it is unknown whether the same is true for locally advanced NPC patients treated with intensity-modulated radiotherapy (IMRT). This study aimed to clarify the prognostic value of tumor volume for patient with locally advanced NPC receiving IMRT and to find a suitable cut-off value of GTV-P for prognosis prediction. METHODS: Clinical data of 358 patients with locally advanced NPC who received IMRT were reviewed...
November 16, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27845572/post-craniotomy-intracranial-infection-in-patients-with-brain-tumors-a-retrospective-analysis-of-5723-consecutive-patients
#12
Zhong-Hua Shi, Ming Xu, Yong-Zhi Wang, Xu-Ying Luo, Guang-Qiang Chen, Xin Wang, Tao Wang, Ming-Zhong Tang, Jian-Xin Zhou
AIM: To determine the risk factors for and the incidence, outcomes, and causative pathogens of post-craniotomy intracranial infection (PCII) in patients with brain tumors. METHODS: A retrospective study was performed of 5723 patients with brain tumors who were surgically treated between January 2012 and December 2013 in Beijing Tiantan Hospital. The patients' demographics, pathohistological diagnoses, surgical procedures, postoperative variables, causative pathogens, and outcomes were evaluated...
November 15, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27835671/an-anti-parkinson-s-disease-drug-via-targeting-adenosine-a2a-receptor-enhances-amyloid-%C3%AE-generation-and-%C3%AE-secretase-activity
#13
Jing Lu, Jin Cui, Xiaohang Li, Xin Wang, Yue Zhou, Wenjuan Yang, Ming Chen, Jian Zhao, Gang Pei
γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer's disease (AD). Here we identified that an anti-Parkinson's disease drug, Istradefylline, could enhance Aβ generation in various cell lines and primary neuronal cells of APP/PS1 mouse. Moreover, the increased generation of Aβ42 was detected in the cortex of APP/PS1 mouse after chronic treatment with Istradefylline. Istradefylline promoted the activity of γ-secretase which could lead to increased Aβ production...
2016: PloS One
https://www.readbyqxmd.com/read/27825411/clinical-features-of-patients-with-castleman-s-disease-complicated-by-br-systemic-lupus-erythematosus
#14
Lu Zhang, Xin-Xin Cao, Shu-Jie Wang, Dao-Bin Zhou, Jian Li
Objective To investigate the clinical features of patients with Castleman's disease (CD) and systemic lupus erythematosus (SLE). Methods According to the diagnostic information between 1994 to 2014 extracted from the database of the Medical Record Department of Peking Union Medical College Hospital (PUMCH),patients with CD and SLE were included. A thorough literature review utilizing the key words of "Castleman's disease","systemic lupus erythematosus","SLE",and "lupus" was performed in PubMed during the same period...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27824671/early-changes-of-irradiated-parotid-glands-evaluated-by-t1rho-weighted-imaging-a-pilot-study
#15
Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Tingting Guo, Lijing Zhu, Baorui Liu, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
OBJECTIVE: The aim of the study was to confirm the feasibility of T1rho-weighted imaging to evaluate the dynamic changes of parotid glands in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiation therapy. METHODS: Twenty-six NPC patients (19 men; 7 women; mean [SD] age, 48.9 [13.4] years) underwent the following 3 serial T1rho-weighted imaging: within 2 weeks before radiotherapy (RT, pre-RT), 5 weeks after the beginning of RT (mid-RT), and 4 weeks after RT (post-RT)...
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27821130/early-evaluation-of-irradiated-parotid-glands-with-intravoxel-incoherent-motion-mr-imaging-correlation-with-dynamic-contrast-enhanced-mr-imaging
#16
Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Lijing Zhu, Baorui Liu, Tingting Guo, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang, Tian Liu
BACKGROUND: Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM perfusion-related parameters in irradiated parotid glands have not been confirmed by conventional perfusion measurements obtained from dynamic contrast-enhanced (DCE) MR imaging...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27810342/interleukin-12-activated-cd8-t-cells-induces-apoptosis-in-breast-cancer-cells-and-reduces-tumor-growth
#17
Shi-Xin Yang, Wen-Song Wei, Qian-Wen Ouyan, Qi-Hua Jiang, Yu-Feng Zou, Wei Qu, Jian-Hong Tu, Zhi-Bing Zhou, Hao-Long Ding, Chun-Wei Xie, Qiu-Mo Lei, Cheng-Ren Zhong
During the past two decades, cytokines have emerged as key molecules to modulate innate and adaptive immunity and mediate anti-tumor activity. Although multiple cytokine types are implicated for such anti-tumor activity in several cancer types, it remains largely unknown in breast cancer. In this study, cytokines that are prior known for antitumor activity in different cancer types were examined against breast cancer using a 4T1 cells based xenograft-model. Our results showed Interleukin-12 (IL-12) (500ng/mouse) significantly suppressed the growth of tumors, while other cytokines showed minimal suppression...
October 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27796324/myocyte-specific-enhancer-factor-2c-a-novel-target-gene-of-mir-214-3p-in-suppressing-angiotensin-ii-induced-cardiomyocyte-hypertrophy
#18
Chun-Mei Tang, Fang-Zhou Liu, Jie-Ning Zhu, Yong-Heng Fu, Qiu-Xiong Lin, Chun-Yu Deng, Zhi-Qin Hu, Hui Yang, Xi-Long Zheng, Jian-Ding Cheng, Shu-Lin Wu, Zhi-Xin Shan
The role of microRNA-214-3p (miR-214-3p) in cardiac hypertrophy was not well illustrated. The present study aimed to investigate the expression and potential target of miR-214-3p in angiotensin II (Ang-II)-induced mouse cardiac hypertrophy. In mice with either Ang-II infusion or transverse aortic constriction (TAC) model, miR-214-3p expression was markedly decreased in the hypertrophic myocardium. Down-regulation of miR-214-3p was observed in the myocardium of patients with cardiac hypertrophy. Expression of miR-214-3p was upregulated in Ang-II-induced hypertrophic neonatal mouse ventricular cardiomyocytes...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789960/prognostic-value-of-fever-grade-combined-with-neutrophil-percentage-in-hepatocellular-carcinoma-patients-presenting-fever-as-the-initial-manifestation
#19
Zi-Jun Gong, Wei Guo, Yun-Fan Sun, Xin Zhang, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Xin-Rong Yang
BACKGROUND: Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS: The clinical features were analyzed in a retrospective study of 63 HCC patients with fever as the first manifestation and 300 HCC patients without fever as the control group. RESULTS: HCC patients with fever had a higher neutrophil percentage, larger tumor size, worse tumor differentiation, advanced Barcelona Clinic Liver Cancer stage, and more hilar lymph node metastasis than HCC patients without fever (all P<0...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27787719/salvianolate-reduces-murine-myocardial-ischemia-and-reperfusion-injury-via-erk1-2-signaling-pathways-in-vivo
#20
Jian-Yong Qi, Juan Yu, Dong-Hui Huang, Li-Heng Guo, Lei Wang, Xin Huang, Hai-Ding Huang, Miao Zhou, Min-Zhou Zhang, Jia-Xing Wu
OBJECTIVE: To analyze the effects of salvianolate on myocardial infarction in a murine in vivo model of ischemia and reperfusion (I/R) injury. METHODS: Myocardial I/R injury model was constructed in mice by 30 min of coronary occlusion followed by 24 h of reperfusion and pretreated with salvianolate 30 min before I/R (SAL group). The SAL group was compared with SHAM (no I/R and no salvianolate), I/R (no salvianolate), and ischemia preconditioning (IPC) groups. Furthermore, an ERK1/2 inhibitor PD98059 (1 mg/kg), and a phosphatidylinositol-3-kinase (PI3-K) inhibitor, LY294002 (7...
October 27, 2016: Chinese Journal of Integrative Medicine
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