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https://www.readbyqxmd.com/read/29897073/novel-single-component-tri-rare-earth-emitting-mof-for-warm-white-light-leds
#1
Hui Li, Hong-Bin Liu, Xiao-Min Tao, Jian Su, Ping-Fan Ning, Xiu-Fang Xu, Yu Zhou, Wen Gu, Xin Liu
Single-phase white phosphors could overcome many drawbacks of traditional phosphors, and warm white light phosphors have been considered suitable for indoor illumination applications. Thus, synthesizing new single-phase warm white phosphors is significant for the production of LEDs. Based on the above considerations, a novel single component warm white light phosphor SmxTbyDy0.2-x-y-metal organic frameworks (MOFs) has been prepared successfully in this study. The compound Sm0.1Tb0.04Dy0.06-MOF shows ideal warm white light emission with CIE coordinates (0...
June 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29891381/activity-of-the-dinitroaniline-fungicide-fluazinam-against-bipolaris-maydis
#2
Ya-Li Chen, Xue-Wei Mao, Jian-Xin Wang, Luo-Yu Wu, Ming-Guo Zhou, Yi-Ping Hou
Fluazinam is a dinitroaniline fungicide with broad-spectrum activities. However, the activity of fluazinam against Bipolaris maydis which is the causal agent of southern corn leaf blight is unknown yet. In this study, baseline sensitivity of B. maydis to fluazinam was determined using 92 isolates collected during 2015 and 2016 from different geographical regions in Jiangsu Province of China, and the EC50 values ranged from 0.0396 to 0.9808 μg/ml with average value of 0.3853 ± 0.2297 μg/ml, and 0...
June 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29883579/endothelial-colony-forming-cell-derived-exosomes-restore-blood-brain-barrier-continuity-in-mice-subjected-to-traumatic-brain-injury
#3
Weiwei Gao, Fei Li, Li Liu, Xin Xu, Baoliang Zhang, Yingang Wu, Dongpei Yin, Shuai Zhou, Dongdong Sun, Ying Huang, Jianning Zhang
Traumatic brain injury (TBI) tends to cause disruption of the blood-brain barrier (BBB). Previous studies have shown that intravenously or intracerebroventricularly infused human umbilical cord blood-derived endothelial colony-forming cells (ECFCs) can home to injury sites and improve outcomes in mice subjected to experimental TBI. Several reports have demonstrated that these cells did not incorporate directly into newly formed vasculature but instead stimulated the proliferation and migration of tissue-resident endothelial cells (ECs) via paracrine mechanisms...
June 5, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29880839/parasitic-insect-derived-mirnas-modulate-host-development
#4
Zhi-Zhi Wang, Xi-Qian Ye, Min Shi, Fei Li, Ze-Hua Wang, Yue-Nan Zhou, Qi-Juan Gu, Xiao-Tong Wu, Chuan-Lin Yin, Dian-Hao Guo, Rong-Min Hu, Na-Na Hu, Ting Chen, Bo-Ying Zheng, Jia-Ni Zou, Le-Qing Zhan, Shu-Jun Wei, Yan-Ping Wang, Jian-Hua Huang, Xiao-Dong Fang, Michael R Strand, Xue-Xin Chen
Parasitic wasps produce several factors including venom, polydnaviruses (PDVs) and specialized wasp cells named teratocytes that benefit the survival of offspring by altering the physiology of hosts. However, the underlying molecular mechanisms for the alterations remain unclear. Here we find that the teratocytes of Cotesia vestalis, an endoparasitoid of the diamondback moth Plutella xylostella, and its associated bracovirus (CvBV) can produce miRNAs and deliver the products into the host via different ways...
June 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/29879956/with-a-new-clip-technique-surgically-inducing-varicocele-in-sprague-dawley-rats
#5
Wen-Bin Guo, Cheng Yang, Jun Bian, Hui Xia, Jian-Kun Yang, Qi-Zhao Zhou, Ming-Kun Chen, Kang-Yi Xue, Wan-Song Zhang, Peng Wang, Xin Li, Cun-Dong Liu
BACKGROUND: We introduced and recreated a more consistent and effective experimental varicocele rat model by a new clip technique. METHODS: A total of 40 rats were numbered and randomly assigned to 5 groups of 8 each, including sham surgery (Group I), conventional (Group II) and clip groups with 0.7, 0.8, 0.9 mm gap widths, respectively (Group III, IV, V). All of the rats in each group were sacrificed at 8 weeks after initial surgery, and the rats forming out with less than 1 mm diameter of left spermatic vein or no presence of the pampiniform plexus dilation were excluded from the experimental groups...
June 7, 2018: BMC Urology
https://www.readbyqxmd.com/read/29870004/a-new-polymorph-of-the-gastrokinetic-drug-cisapride-monohydrate
#6
Xin Bo Zhou, Jian Rong Zhu, Jian Ming Gu, Xiu Rong Hu
Cisapride monohydrate (systematic name: 4-amino-5-chloro-N-{(3RS,4SR)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide monohydrate), C23 H29 ClFN3 O4 ·H2 O, is a nondopamine-blocking gastrokinetic drug. A new polymorph of cisapride monohydrate has been reported nearly three decades after the report of its first known crystal structure [Collin et al. (1989). J. Mol. Struct. 214, 159-175]. The second polymorph is also monoclinic, but with different unit-cell parameters. A comparison of both polymorphic forms shows that the difference is thus not in the molecular conformation but in the arrangements of molecules in the crystal packing...
June 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29867225/ripk4-promotes-bladder-urothelial-carcinoma-cell-aggressiveness-by-upregulating-vegf-a-through-the-nf-%C3%AE%C2%BAb-pathway
#7
Jian-Ye Liu, Qing-Hai Zeng, Pei-Guo Cao, Dan Xie, Xin Chen, Fei Yang, Le-Ye He, Ying-Bo Dai, Jing-Jing Li, Xiao-Ming Liu, Hong-Liang Zeng, Yi-Xin Zhu, Lian Gong, Yan Cheng, Jian-Da Zhou, Jun Hu, Hao Bo, Zhen-Zhou Xu, Ke Cao
BACKGROUND: Constitutively activated nuclear factor kappa B (NF-κB) signalling plays vital roles in bladder urothelial carcinoma (BC) progression. We investigate the effect of receptor-interacting protein kinase 4 (RIPK4) on NF-κB activation and BC progression. METHODS: The expression of RIPK4 was examined in 25 cryopreserved paired bladder samples and 112 paraffin BC specimens. In vivo and in vitro assays were performed to validate effect of RIPK4 on NF-κB pathway-mediated BC progression...
June 5, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29863012/dexmedetomidine-attenuates-traumatic-brain-injury-action-pathway-and-mechanisms
#8
Dong Wang, Xin Xu, Yin-Gang Wu, Li Lyu, Zi-Wei Zhou, Jian-Ning Zhang
Traumatic brain injury induces potent inflammatory responses that can exacerbate secondary blood-brain barrier (BBB) disruption, neuronal injury, and neurological dysfunction. Dexmedetomidine is a novel α2-adrenergic receptor agonist that exert protective effects in various central nervous system diseases. The present study was designed to investigate the neuroprotective action of dexmedetomidine in a mouse traumatic brain injury model, and to explore the possible mechanisms. Adult male C57BL/6J mice were subjected to controlled cortical impact...
May 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29862177/diagnostic-ability-of-ganglion-cell-complex-thickness-to-detect-glaucoma-in-high-myopia-eyes-by-fourier-domain-optical-coherence-tomography
#9
Wei-Wei Wang, Huai-Zhou Wang, Jian-Rong Liu, Xi-Fang Zhang, Meng Li, Yan-Jiao Huo, Xin-Guang Yang
AIM: To evaluate the ability of macular ganglion cell complex (GCC) thickness using Fourier domain optical coherence tomography (FD-OCT) to detect glaucoma in highly myopic eyes. METHODS: Cross-sectional study. A total of 114 participants, consecutively were enrolled. Macular GCC thickness and peripapillary retinal nerve fiber layer (RNFL) thickness were obtained with RTVue FD-OCT. Receiver operating characteristics curves were constructed for each measurement parameter, and areas under the curves (AUCs) were compared...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29859317/selective-nlrp3-inflammasome-inhibitor-reduces-neuroinflammation-and-improves-long-term-neurological-outcomes-in-a-murine-model-of-traumatic-brain-injury
#10
Xin Xu, Dongpei Yin, Honglei Ren, Weiwei Gao, Fei Li, Dongdong Sun, Yingang Wu, Shuai Zhou, Li Lyu, Mengchen Yang, Jianhua Xiong, Lulu Han, Rongcai Jiang, Jianning Zhang
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a prominent contributor to the pathophysiological processes of traumatic brain injury (TBI). Recently, a potent, selective, small-molecule NLRP3 inflammasome inhibitor, MCC950, was described. Here, we investigated the effect of MCC950 on inflammatory brain injury and long-term neurological outcomes in a mouse model of TBI. Male C57/BL6 mice were subjected to TBI using the controlled cortical impact injury (CCI) system...
May 30, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29851854/use-of-the-critical-care-pain-observation-tool-and-the-bispectral-index-for-the-detection-of-pain-in-brain-injured-patients-undergoing-mechanical-ventilation-a-strobe-compliant-observational-study
#11
Kai Shan, Wei Cao, Yuan Yuan, Jing-Jing Hao, Xiu-Mei Sun, Xuan He, Gui-Yun Li, Yu-Mei Wang, Jian-Xin Zhou
The assessment of pain in patients with brain injury is challenging due to impaired ability to communicate. We aimed to test the reliability and validity of the critical-care pain observation tool (CPOT) and the bispectral index (BIS) for pain detection in critically brain-injured patients.This prospective observational study was conducted in a neurosurgical intensive care unit in a University-Affiliated Hospital. Adult brain-injured patients undergoing mechanical ventilation were enrolled. Nociceptive (endotracheal suctioning) and non-nociceptive (gentle touching) procedures were performed in a random crossover fashion...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29850142/the-diagnosis-of-coronary-plaque-stability-by-multi-slice-computed-tomography-coronary-angiography
#12
Feng-Xiang Song, Jun Zhou, Jian-Jun Zhou, Yu-Xin Shi, Meng-Su Zeng, Zhi-Yong Zhang, Peng Lv, Ruo-Fan Sheng
Background: Coronary computed tomographic angiography is a robust non-invasive method to assess coronary artery disease (CAD) and analyze coronary plaque stability, especially for the non-calcified plaques. The aim of this study was to investigate the differential characteristics between the unstable coronary plaques and the stable coronary plaques using multi-slice computed tomography (MSCT). Methods: Sixty patients with coronary heart disease (37 unstable plaques and 31 stable plaques) were included...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29842893/lethal-2-giant-larvae-regulates-pleural-mesothelial-cell-polarity-in-pleural-fibrosis
#13
Lin-Jie Song, Li-Ling Zhou, Meng Wang, Fei Liu, Liang Xiong, Fei Xiang, Fan Yu, Xin-Liang He, Juan-Juan Xu, Huan-Zhong Shi, Jian-Bao Xin, Wan-Li Ma, Hong Ye
Pleural fibrosis is barely reversible and the underlying mechanisms are poorly understood. Pleural mesothelial cells (PMCs) which have apical-basal polarity play a key role in pleural fibrosis. Loss of cell polarity is involved in the development of fibrotic diseases. Partition defective protein (PAR) complex is a key regulator of cell polarity. However, changes of PMC polarity and PAR complex in pleural fibrosis are still unknown. In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss...
May 26, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29842860/dexmedetomidine-attenuated-early-brain-injury-in-rats-with-subarachnoid-haemorrhage-by-suppressing-the-inflammatory-response-the-tlr4-nf-%C3%AE%C2%BAb-pathway-and-the-nlrp3-inflammasome-may-be-involved-in-the-mechanism
#14
Dongpei Yin, Shuai Zhou, Xin Xu, Weiwei Gao, Fei Li, Yuyang Ma, Dongdong Sun, Yingang Wu, Qi Guo, Huimin Liu, Lulu Han, Zengguang Wang, Yi Wang, Jianning Zhang
Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprotective functions in EBI after SAH, and to explore the possible mechanisms. The SAH model was established by an endovascular perforation in adult male Sprague-Dawley (SD) rats. DEX (25 µg/kg) or vehicle was administered intraperitoneally 2 hours after SAH...
May 26, 2018: Brain Research
https://www.readbyqxmd.com/read/29806024/defect-engineered-epitaxial-vo-2%C3%A2-%C3%AE-in-strain-engineering-of-heterogeneous-soft-crystals
#15
Yiping Wang, Xin Sun, Zhizhong Chen, Zhonghou Cai, Hua Zhou, Toh-Ming Lu, Jian Shi
The success of strain engineering has made a step further for the enhancement of material properties and the introduction of new physics, especially with the discovery of the critical roles of strain in the heterogeneous interface between two dissimilar materials (for example, FeSe/SrTiO3 ). On the other hand, the strain manipulation has been limited to chemical epitaxy and nanocomposites that, to a large extent, limit the possible material systems that can be explored. By defect engineering, we obtained, for the first time, dense three-dimensional strongly correlated VO2±δ epitaxial nanoforest arrays that can be used as a novel "substrate" for dynamic strain engineering, due to its metal-insulator transition...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29805574/significance-of-pivka-ii-levels-for-predicting-microvascular-invasion-and-tumor-cell-proliferation-in-chinese-patients-with-hepatitis-b-virus-associated-hepatocellular-carcinoma
#16
Xiao-Lu Ma, Jing Zhu, Jiong Wu, Lu Tian, Yao-Yi Gao, Chun-Yan Zhang, Yan Zhou, Qian Dai, Bei-Li Wang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
The present study aimed to determine the levels of prothrombin induced by vitamin K absence-II (PIVKA-II) according to the Barcelona Clinic Liver Cancer (BCLC) staging system, to develop an appropriate strategy for managing hepatocellular carcinoma (HCC), particularly early HCC, and to investigate the value of PIVKA-II for predicting prognosis-associated pathological parameters. Clinical information of 117 patients with hepatitis B-associated HCC was retrospectively collected. Preoperative serum PIVKA-II and α-fetoprotein (AFP) levels were measured using a chemiluminescence method...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29802174/effect-of-huaier-granule-on-recurrence-after-curative-resection-of-hcc-a-multicentre-randomised-clinical-trial
#17
Qian Chen, Chang Shu, Arian D Laurence, Yan Chen, Bao-Gang Peng, Zuo-Jun Zhen, Jian-Qiang Cai, Yi-Tao Ding, Le-Qun Li, Yu-Bao Zhang, Qi-Chang Zheng, Ge-Liang Xu, Bo Li, Wei-Ping Zhou, Shou-Wang Cai, Xi-Yan Wang, Hao Wen, Xin-Yu Peng, Xue-Wen Zhang, Chao-Liu Dai, Ping Bie, Bao-Cai Xing, Zhi-Ren Fu, Lian-Xin Liu, Yi Mu, Ling Zhang, Qi-Shun Zhang, Bin Jiang, Hai-Xin Qian, Yi-Jun Wang, Jing-Feng Liu, Xi-Hu Qin, Qiang Li, Ping Yin, Zhi-Wei Zhang, Xiao-Ping Chen
OBJECTIVE: There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall survival (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit of an aqueous extract of Trametes robinophila Murr (Huaier granule) to address this unmet need. DESIGN AND RESULTS: A total of 1044 patients were randomised in 2:1 ratio to receive either Huaier or no further treatment (controls) for a maximum of 96 weeks...
May 25, 2018: Gut
https://www.readbyqxmd.com/read/29801514/intrauterine-hyperglycemia-exposure-results-in-intergenerational-inheritance-via-dna-methylation-reprogramming-on-f1-pgcs
#18
Jun Ren, Yi Cheng, Zhen-Hua Ming, Xin-Yan Dong, Yu-Zhong Zhou, Guo-Lian Ding, Hai-Yan Pang, Tanzil Ur Rahman, Rubab Akbar, He-Feng Huang, Jian-Zhong Sheng
BACKGROUND: The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both intrauterine and postnatal metabolic exposure factors, while the impact of intrauterine hyperglycemia per se has not been assessed alone. A number of studies suggest DNA methylation reprogramming of gametes plays a crucial role in the metabolic inheritance, but it is unclear when and how DNA methylation patterns are altered when exposed to intrauterine hyperglycemia...
May 25, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29777452/revision-of-surgical-margin-under-frozen-section-to-achieve-r0-status-on-survival-in-patients-with-pancreatic-cancer
#19
Zi Yin, Yu Zhou, Baohua Hou, Tingting Ma, Min Yu, Chuanzhao Zhang, Xin Lu, Zhixiang Jian
OBJECTIVE: The aim is to investigate whether additional resection based on intraoperative frozen section (FS) to a secondary R0(s) status are associated with different long-term survivals in pancreatic cancer patients, comparing to those with R1 or primary R0(p) status. METHODS: A systematic literature search (PubMed, Embase, Science Citation Index, Springer-Link, and Cochrane Central Register of Controlled Trials) was performed to identify all studies published up to June 2017...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29774072/twist-promotes-tumor-metastasis-in-basal-like-breast-cancer-by-transcriptionally-upregulating-ror1
#20
Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P Zhou, Jian Shi, Tiebang Kang
Rationale: Twist is a key transcription factor for induction of epithelial-mesenchymal transition (EMT), which promotes cell migration, invasion, and cancer metastasis, confers cancer cells with stem cell-like characteristics, and provides therapeutic resistance. However, the functional roles and targeted genes of Twist in EMT and cancer progression remain elusive. Methods: The potential targeted genes of Twist were identified from the global transcriptomes of T47D/Twist cells by microarray analysis. EMT phenotype was detected by western blotting and immunofluorescence of marker proteins...
2018: Theranostics
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