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COMMENT
Ewan C Goligher, Patrick R Lawler, Ryan Zarychanski
No abstract text is available yet for this article.
August 1, 2023: JAMA
#22
LETTER
Ewan C Goligher, James J McNamee, Jose Dianti, Eddy Fan, Niall D Ferguson, Arthur S Slutsky, Daniel F McAuley
No abstract text is available yet for this article.
September 15, 2023: American Journal of Respiratory and Critical Care Medicine
#23
JOURNAL ARTICLE
Ricardo Teijeiro-Paradis, Jasmine Grenier, Martin Urner, Ghislaine Douflé, Andrew Steel, Marcelo Cypel, Shaf Keshavjee, Margaret Herridge, Ewan Goligher, John Granton, Niall Ferguson, Eddy Fan, Lorenzo Del Sorbo
PURPOSE: Descriptive information on referral patterns and short-term outcomes of patients with respiratory failure declined for extracorporeal membrane oxygenation (ECMO) is lacking. METHODS: We conducted a prospective single-centre observational cohort study of ECMO referrals to Toronto General Hospital (receiving hospital) for severe respiratory failure (COVID-19 and non-COVID-19), between 1 December 2019 and 30 November 2020. Data related to the referral, the referral decision, and reasons for refusal were collected...
July 2023: Canadian Journal of Anaesthesia
#24
EDITORIAL
Ewan C Goligher, Anna Heath
No abstract text is available yet for this article.
June 2023: Annals of the American Thoracic Society
#25
JOURNAL ARTICLE
Oriol Roca, Ewan C Goligher, Marcelo B P Amato
No abstract text is available yet for this article.
August 2023: Intensive Care Medicine
#26
JOURNAL ARTICLE
Jose Dianti, Idunn S Morris, Ewan C Goligher
No abstract text is available yet for this article.
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#27
MULTICENTER STUDY
Annemijn H Jonkman, Glasiele C Alcala, Bertrand Pavlovsky, Oriol Roca, Savino Spadaro, Gaetano Scaramuzzo, Lu Chen, Jose Dianti, Mayson L de A Sousa, Michael C Sklar, Thomas Piraino, Huiqing Ge, Guang-Qiang Chen, Jian-Xin Zhou, Jie Li, Ewan C Goligher, Eduardo Costa, Jordi Mancebo, Tommaso Mauri, Marcelo Amato, Laurent J Brochard
Rationale: Defining lung recruitability is needed for safe positive end-expiratory pressure (PEEP) selection in mechanically ventilated patients. However, there is no simple bedside method including both assessment of recruitability and risks of overdistension as well as personalized PEEP titration. Objectives: To describe the range of recruitability using electrical impedance tomography (EIT), effects of PEEP on recruitability, respiratory mechanics and gas exchange, and a method to select optimal EIT-based PEEP...
July 1, 2023: American Journal of Respiratory and Critical Care Medicine
#28
JOURNAL ARTICLE
Gregory R De Meyer, Loïc Flamey, Ine Adriaensens, Marjan Van der Aerschot, Hanne Van de Walle, Ignace Vanmarsenille, Philippe G Jorens, Ewan C Goligher, Vera Saldien, Tom Schepens
OBJECTIVES: Diaphragm ultrasound is a novel alternative to esophageal pressure measurements in the evaluation of diaphragm function and activity, but data about its reliability in a pediatric setting are lacking. We aimed to compare the esophageal pressure swing (∆P es , gold standard) with the diaphragmatic thickening fraction (DTF) as a measure of inspiratory effort in sedated children. Additionally, we studied the effect of positive end-expiratory pressure (PEEP) on the end-expiratory thickness of the diaphragm (DT ee )...
August 1, 2023: Pediatric Critical Care Medicine
#29
JOURNAL ARTICLE
Karen J Bosma, Claudio M Martin, Karen E A Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji, Gaëtan Beduneau, Francois Beloncle, Guillaume Carteaux, Emmanuel Charbonney, Alexandre Demoule, Martin Dres, Vito Fanelli, Anna Geagea, Ewan Goligher, François Lellouche, Tommaso Maraffi, Alain Mercat, Pablo O Rodriguez, Jason Shahin, Stephanie Sibley, Savino Spadaro, Katerina Vaporidi, M Elizabeth Wilcox, Laurent Brochard
BACKGROUND: Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mechanical ventilation mode that delivers assistance to breathe in proportion to the patient's effort. The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload within a normal range. Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better patient-ventilator synchrony and a more physiological response to changes in ventilatory demand...
March 27, 2023: Trials
#30
JOURNAL ARTICLE
Ewan C Goligher, Patrick R Lawler, Thomas P Jensen, Victor Talisa, Lindsay R Berry, Elizabeth Lorenzi, Bryan J McVerry, Chung-Chou Ho Chang, Eric Leifer, Charlotte Bradbury, Jeffrey Berger, Beverly J Hunt, Lana A Castellucci, Lucy Z Kornblith, Anthony C Gordon, Colin McArthur, Steven Webb, Judith Hochman, Matthew D Neal, Ryan Zarychanski, Scott Berry, Derek C Angus
IMPORTANCE: Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding of HTE could facilitate individualized clinical decision-making. OBJECTIVE: To evaluate HTE of therapeutic-dose heparin for patients hospitalized for COVID-19 and to compare approaches to assessing HTE. DESIGN, SETTING, AND PARTICIPANTS: Exploratory analysis of a multiplatform adaptive RCT of therapeutic-dose heparin vs usual care pharmacologic thromboprophylaxis in 3320 patients hospitalized for COVID-19 enrolled in North America, South America, Europe, Asia, and Australia between April 2020 and January 2021...
March 21, 2023: JAMA
#31
JOURNAL ARTICLE
Dmitry Rozenberg, Noor Al Kaabi, Encarna Camacho Perez, Sahar Nourouzpour, Laura Lopez-Hernandez, Laura McGillis, Ewan Goligher, W Darlene Reid, Chung-Wai Chow, Clodagh M Ryan, Dinesh Kumbhare, Ella Huszti, Kateri Champagne, Satish Raj, Susanna Mak, Daniel Santa Mina, Hance Clarke, Nimish Mittal
BACKGROUND: Dyspnea is a prevalent symptom in individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and generalized hypermobility spectrum disorder (G-HSD), yet its contributors have not been identified. One known contributor to dyspnea is respiratory muscle weakness. The feasibility and effectiveness of inspiratory muscle training (IMT) in combination with standard-of-care rehabilitation (aerobic, resistance, neuromuscular stabilization, and balance and proprioception exercises) in improving respiratory muscle strength and patient-reported outcomes in patients with hEDS or G-HSD have not been evaluated...
March 20, 2023: JMIR Research Protocols
#32
JOURNAL ARTICLE
Shaurya Taran, Benjamin Coiffard, Ella Huszti, Qixuan Li, Leslie Chu, Claire Thomas, Stacey Burns, Priscila Robles, Margaret S Herridge, Ewan C Goligher
IMPORTANCE: Many conventional end points in randomized clinical trials of interventions for critically ill patients do not account for patient-centered concerns such as time at home, physical function, and quality of life after critical illness. OBJECTIVE: To establish whether days alive and at home at day 90 (DAAH90) is associated with long-term survival and functional outcomes in mechanically ventilated patients. DESIGN, SETTING, AND PARTICIPANTS: The RECOVER prospective cohort study was conducted from February 2007 to March 2014, using data from 10 intensive care units (ICUs) in Canada...
March 1, 2023: JAMA Network Open
#33
REVIEW
Harry Etienne, Idunn S Morris, Greet Hermans, Leo Heunks, Ewan C Goligher, Samir Jaber, Capucine Morelot-Panzini, Jalal Assouad, Jésus Gonzalez-Bermejo, Laurent Papazian, Thomas Similowski, Alexandre Demoule, Martin Dres
Diaphragm neurostimulation consists of placing electrodes directly on or in proximity to the phrenic nerve(s) to elicit diaphragmatic contractions. Since its initial description in the 18th century, indications have shifted from cardiopulmonary resuscitation to long-term ventilatory support. Recently, the technical development of devices for temporary diaphragm neurostimulation has opened up the possibility of a new era for the management of mechanically ventilated patients. Combining positive pressure ventilation with diaphragm neurostimulation offers a potentially promising new approach to the delivery of mechanical ventilation which may benefit multiple organ systems...
May 15, 2023: American Journal of Respiratory and Critical Care Medicine
#34
JOURNAL ARTICLE
Tyler Pitre, Samantha Cheng, Ellen Cusano, Nadia Khan, David Mikhail, Gareth Leung, Robin W M Vernooij, Christopher J Yarnell, Ewan Goligher, Srinivas Murthy, Anna Heath, Jasmine Mah, Bram Rochwerg, Dena Zeraatkar
OBJECTIVES: Adaptive platforms allow for the evaluation of multiple interventions at a lower cost and have been growing in popularity, especially during the COVID-19 pandemic. The objective of this review is to summarize published platform trials, examine specific methodological design features among these studies, and hopefully aid readers in the evaluation and interpretation of platform trial results. METHODS: We performed a systematic review of EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials...
March 8, 2023: Journal of Clinical Epidemiology
#35
EDITORIAL
Jose Dianti, Ewan C Goligher
No abstract text is available yet for this article.
March 1, 2023: Anesthesiology
#36
JOURNAL ARTICLE
Jose Dianti, Idunn S Morris, Martin Urner, Marcello Schmidt, George Tomlinson, Marcelo B P Amato, Lluis Blanch, Gordon Rubenfeld, Ewan C Goligher
ICU clinicians rely on bedside physiological measurements to inform many routine clinical decisions. Because deranged physiology is usually associated with poor clinical outcomes, it is tempting to hypothesize that manipulating and intervening on physiological parameters might improve outcomes for patients. However, testing these hypotheses through mathematical models of the relationship between physiology and outcomes presents a number of important methodological challenges. These models reflect the theories of the researcher and can therefore be heavily influenced by one's assumptions and background beliefs...
June 1, 2023: American Journal of Respiratory and Critical Care Medicine
#37
MULTICENTER STUDY
Tài Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, Gaëtan Beduneau, Ewan C Goligher, Giacomo Grasselli, Jon Henrik Laake, Jordi Mancebo, Oscar Peñuelas, Lise Piquilloud, Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G Laffey
BACKGROUND: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. METHODS: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer...
May 2023: Lancet Respiratory Medicine
#38
JOURNAL ARTICLE
Alisa M Higgins, Lindsay R Berry, Elizabeth Lorenzi, Srinivas Murthy, Zoe McQuilten, Paul R Mouncey, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Abi Beane, Wilma van Bentum-Puijk, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Aidan Burrell, Adrian Buzgau, Meredith Buxton, Walton N Charles, Matthew Cove, Michelle A Detry, Lise J Estcourt, Elizabeth O Fagbodun, Mark Fitzgerald, Timothy D Girard, Ewan C Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, Christopher M Horvat, David T Huang, Nao Ichihara, Francois Lamontagne, John C Marshall, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Matthew D Neal, Alistair D Nichol, Rachael L Parke, Jane C Parker, Karen Parry-Billings, Sam E C Peters, Luis F Reyes, Kathryn M Rowan, Hiroki Saito, Marlene S Santos, Christina T Saunders, Ary Serpa-Neto, Christopher W Seymour, Manu Shankar-Hari, Lucy M Stronach, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Lennie P G Derde, Anthony C Gordon, Steve A Webb, Patrick R Lawler
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. DESIGN, SETTING, AND PARTICIPANTS: Prespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries...
January 3, 2023: JAMA
#39
JOURNAL ARTICLE
John Tambakis, Lauris Kaldijian, Ewan C Goligher
Contemporary bioethics generally stipulates that public moral deliberation must avoid allowing religious beliefs to influence or justify health policy and law. Secular premises and arguments are assumed to maintain the neutral, common ground required for moral deliberation in the public square of a pluralistic society. However, a careful examination of non-theistic arguments used to justify euthanasia (regarding contested notions of human dignity, individual autonomy, and death as annihilation) reveals a dependence on metaethical and metaphysical beliefs that are not universally accepted in a pluralistic society...
November 30, 2022: Theoretical Medicine and Bioethics
#40
EDITORIAL
Idunn S Morris, Ewan C Goligher
No abstract text is available yet for this article.
November 2022: Respiratory Care
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