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https://www.readbyqxmd.com/read/29236293/real-time-pcr-to-evaluate-hsv-2-shedding-from-anal-and-genital-samples-among-men-who-have-sex-with-men-living-with-hiv
#1
Dayana Nicté Vergara-Ortega, Edgar Enrique Sevilla-Reyes, Antonia Herrera-Ortiz, Leticia Torres-Ibarra, Jorge Salmerón, Eduardo Lazcano-Ponce, Miguel Angel Sánchez-Alemán
This study shows the relative quantification of HSV-2 by qPCR, using the MIQE Guidelines. The reaction efficiency was evaluated, and the relative quantification used the R=2-ΔCq method. The relative quantification of HSV-2 was conducted with anal and genital samples from men who have sex with men (MSM), living with HIV. The presence of a single amplification product was validated with a dissociation curves profile and the determination of the melting temperature. The limit of detection for β-globin was determined as 3...
December 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29235934/learning-from-guidelines-on-the-sexual-healthcare-of-men-who-have-sex-with-men
#2
Dan Clutterbuck
The British Association for Sexual Health and HIV (BASHH) United Kingdom national guideline on the sexual health care of men who have sex with men (MSM) was published in electronic format in this journal in 2017. In common with other BASHH guidelines, the document fulfils the dual role of scrutinising and evaluating the available evidence according to the accredited Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, as well as the often more challenging job of codifying and summarising expert opinion in areas where the evidence base is incomplete or lacking...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29229528/palmitoyl-ceramide-promotes-milk-sphingomyelin-gel-phase-domains-formation-and-affects-the-mechanical-properties-of-the-fluid-phase-in-milk-sm-dopc-supported-membranes
#3
Appala Venkata Ramana Murthy, Fanny Guyomarc'h, Christelle Lopez
Ceramides are minor structural components of membranes involved in biological functions. In the milk fat globule membrane (MFGM), ceramides are susceptible to affect the lateral packing of polar lipids, especially the milk sphingomyelin (MSM). To investigate this, palmitoylceramide (PCer) was added to MSM/DOPC (dioleoylphosphatidylcholine) in order to form hydrated lipid bilayers. Differential scanning calorimetry evidenced interactions of PCer with the MSM in the solid-ordered phase to form MSM/PCer structures with a higher thermostability than MSM...
December 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29227887/-there-is-not-a-safe-space-where-they-can-find-themselves-to-be-free-un-safe-spaces-and-the-promotion-of-queer-visibilities-among-township-males-who-have-sex-with-males-msm-in-cape-town-south-africa
#4
N R Hassan, L Swartz, A Kagee, A De Wet, A Lesch, Z Kafaar, P A Newman
Males who have sex with males (MSM) are prioritised in the global fight against HIV/AIDS, as a key affected population to receive HIV prevention, treatment, and HIV-related care and support (WHO, 2016). There is, however, limited empirical research conducted on how to engage communities of South African MSM in clinical HIV prevention research programs. The development of LGBTIQ safe spaces may potentially be a viable option to promote community-based engagement by bridging the divides between HIV-prevention researchers, marginalised queer populations, and other HIV-prevention stakeholders located in heteronormative spaces (Molyneux et al...
December 8, 2017: Health & Place
https://www.readbyqxmd.com/read/29226692/identification-of-a-novel-hiv-1-unique-recombinant-form-between-b-crf01_ae-and-crf07_bc-in-men-who-have-sex-with-men-in-guangxi-china
#5
Desheng Kong, Yan Wang, Chen Wang, Shujia Liang, Yi Feng, Yiming Shao, Liying Ma
B, CRF01_AE and CRF07_BC are three major HIV-1 subtypes circulating in China. Here we detected a novel CCR5-tropic HIV-1 recombinant virus (GX2014EU23), which was isolated from an HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of the near full-length genome (NFLG) showed that GX2014EU23 was consisted of at least 7 segments, including two B, two CRF01_AE and three CRF07_BC segments. Recombinant breakpoints of GX2014EU23 were observed in the gag, pol, rev and env regions...
December 10, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29224176/validation-of-a-method-for-estimating-energy-expenditure-during-walking-in-middle-aged-adults
#6
Nathan Caron, Teddy Caderby, Nicolas Peyrot, Chantal Verkindt, Georges Dalleau
PURPOSE: The aim of this study was to test the validity of a method using an inertial measurement unit for estimating activity-related energy expenditure (AEE) during walking in middle-aged adults. METHODS: Twenty healthy middle-aged participants completed different treadmill walking trials with an inertial measurement unit adhered to their lower back. Gas exchange was monitored with indirect calorimetry. Mechanical data were used to estimate AEE from an algorithm developed by Bouten et al...
December 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29223963/field-evaluation-of-two-point-of-care-tests-for-syphilis-among-men-who-have-sex-with-men-verona-italy
#7
Antonella Zorzi, Maddalena Cordioli, Lorenzo Gios, Paola Del Bravo, Igor Toskin, Rosanna W Peeling, Karel Blondeel, Giuseppe Cornaglia, James Kiarie, Ronald Ballard, Massimo Mirandola
OBJECTIVES: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. METHODS: The study was undertaken in Verona, Italy. Asymptomatic MSM, potentially exposed to syphilis, were enrolled prospectively. The POCTs evaluated were SD Bioline Syphilis 3...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223761/chemsex-risk-behaviours-and-sexually-transmitted-infections-among-men-who-have-sex-with-men-in-dublin-ireland
#8
Ronan W Glynn, Niamh Byrne, Siobhan O'Dea, Adam Shanley, Mary Codd, Eamon Keenan, Mary Ward, Derval Igoe, Susan Clarke
BACKGROUND: Drug use for or during sex ('chemsex') among MSM has caused concern, because of the direct effects of the drugs themselves, and because of an increased risk of transmission of sexually transmitted infections (STIs). This study aimed to assess the prevalence of chemsex, associated behaviours and STIs among attendees at Ireland's only MSM-specific sexual health clinic in Dublin over a six week period in 2016. METHODS: The questionnaire collected demographic data, information on sexuality and sexual practice, self-reported history of treatment for STIs, and chemsex use...
December 7, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29220586/co-occurring-psychosocial-problems-and-multiple-sexual-partners-among-men-who-have-sex-with-men-in-shanghai-china-a-syndemic-approach
#9
Zezhou Wang, Xu Zhao, Zhan Zhang, Mengyun Luo, Qiuming Shen, Yuanyuan Dong, Ying Wang, Yong Cai
We aimed to apply syndemic theory to verify the association and reinforcing effects between psychosocial problems and multiple sexual partners (MSP) of men who have sex with men (MSM) in Shanghai, China. A cross-sectional study was conducted among 547 MSM in Shanghai, China using a face-to-face survey. Sociodemographic and psychosocial data were collected, as well as information on MSP and condomless anal sex. In the 6 months prior to the survey, 54.3% of the MSM sample had had MSP. Univariate analysis showed that self-esteem, depression, loneliness, sexual compulsivity, and involuntary subordination (IS) were associated with MSP...
December 8, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29218602/correlates-of-serosorting-and-knowledge-of-sexual-partner-s-hiv-status-among-men-who-have-sex-with-men-in-ukraine
#10
Olena Iakunchykova, Viktor Burlaka, Elizabeth J King
Ukraine has among the highest rates of newly diagnosed HIV infections in the WHO European region. Men who have sex with men (MSM) is the least studied group in the context of the HIV epidemics in Ukraine. The present paper aims to estimate the prevalence and correlates of knowledge of sexual partner's HIV status and potentially discordant anal intercourse (failure to serosort) among MSM. Data of the cross-sectional study among 8100 MSM in Ukraine in 2013 were used for this analysis. Less than half of the participants (42...
December 7, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29216355/prevalence-of-and-risk-factors-for-anal-hpv-among-a-sample-of-predominantly-black-men-who-have-sex-with-men-in-houston-texas
#11
Alan G Nyitray, Kayo Fujimoto, Jing Zhao, Anna R Giuliano, John A Schneider, Lu-Yu Hwang
Introduction: Young men who have sex with men (MSM) are at increased risk for human papillomavirus (HPV)-associated disease as a result of HPV infection. Our objective was to characterize high-risk anal HPV prevalence, and factors associated with prevalence, among a group of young, primarily black, MSM in Houston, Texas. Background: Young MSM, aged 18-29 years, were recruited using a respondent-driven sampling method to study HIV/STD transmission and risk. The current analysis estimated HPV prevalence among 135 primarily young black MSM who engaged in peer recruitment chains and who self-collected anal exfoliated cells...
December 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29214616/a-randomized-controlled-trial-evaluating-methylsulfonylmethane-versus-placebo-to-prevent-knee-pain-in-military-initial-entry-trainees
#12
David J Tennent, Christina M Hylden, Benjamin K Kocher, James K Aden, Anthony E Johnson
BACKGROUND: Methylsulfonylmethane (MSM) is a naturally occurring sulfur containing substance that has been shown to have anti-inflammatory and antioxidative properties. Previous studies using MSM as an oral supplement to improve pain in those patients with knee osteoarthritis have shown superiority compared to placebo. However, these studies are not translatable to active individuals performing high impact activities and have not evaluated MSM as a preventative measure. METHODS: A total of 180 subjects ranging in age from 18 to 40 years were enrolled...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29214409/strategies-to-implement-pre-exposure-prophylaxis-with-men-who-have-sex-with-men-in-ukraine
#13
Alex Dubov, Liana Fraenkel, Roman Yorick, Adedotun Ogunbajo, Frederick L Altice
Ukrainian men who have sex with men (MSM) remain highly stigmatized group with HIV prevalence as high as 23%. Despite documented effectiveness of pre-exposure prophylaxis (PrEP), PrEP remains unavailable in Ukraine. The aim of this study was to elicit MSM preferences in order to inform program development to facilitate successful delivery of PrEP to Ukrainian MSM. 1184 MSM were recruited through social networking applications to complete a stated preference (choice-based conjoint) survey. Respondents completed 14 choice tasks presenting experimentally-varied combinations of five attributes related to PrEP administration (dosing frequency, dispensing venue, prescription practices, adherence support, and costs)...
December 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29211874/prevalence-incidence-and-clearance-of-anal-high-risk-human-papillomavirus-hpv-infection-among-hiv-infected-men-in-the-sun-study
#14
Pragna Patel, Tim Bush, Erna Milunka Kojic, Lois Conley, Elizabeth R Unger, Teresa M Darragh, Keith Henry, John Hammer, Gerome Escota, Joel M Palefsky, John T Brooks
Background: The natural history of anal HPV infection among HIV-infected men is unknown. Methods: We collected anal swabs for cytology, HPV detection, and genotyping at annual visits from 2004-2012. We examined baseline prevalence, incidence and clearance of anal HPV infection at 48 months, and associated factors among HIV-infected men. Results: We examined 403 men who have sex with men (MSM) and 96 men who have sex with women (MSW) (median age 42 years for both, 87 vs...
December 4, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29211514/hiv-care-providers-intentions-to-prescribe-and-actual-prescription-of-pre-exposure-prophylaxis-to-at-risk-adolescents-and-adults
#15
Tanya L Kowalczyk Mullins, Gregory Zimet, Michelle Lally, Jiahong Xu, Sarah Thornton, Jessica A Kahn
Pre-exposure prophylaxis (PrEP) is indicated for use in US adults, and little is known about clinician intentions to prescribe and actual prescription of PrEP to adolescents younger than 18. Fifty-six clinicians who care for HIV-infected and at-risk youth completed an anonymous online survey in 2014. Primary outcomes were (1) intentions to prescribe PrEP to adolescents and adults in four risk categories [men who have sex with men (MSM), transgender women, heterosexuals with multiple partners of unknown HIV status, heterosexuals with HIV-infected partners]; and (2) actual prescription of PrEP to adolescents and adults in these risk groups...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211513/facilitators-and-barriers-to-pre-exposure-prophylaxis-willingness-among-young-men-who-have-sex-with-men-who-use-geosocial-networking-applications-in-california
#16
Ian W Holloway, Diane Tan, Jennifer L Gildner, Sean C Beougher, Craig Pulsipher, Jorge A Montoya, Aaron Plant, Arleen Leibowitz
While correlates of pre-exposure prophylaxis (PrEP) uptake have been explored among older men who have sex with men (MSM), less is known about the facilitators and barriers that encourage uptake among younger MSM (YMSM). This study explores the association between willingness to take PrEP and demographic characteristics, sexual risk, and substance use, and attitudinal factors among YMSM in California who use geosocial networking applications (GSN apps). Based on survey data from YMSM recruited through GSN apps (n = 687), PrEP willingness was positively associated with Hispanic ethnicity [adjusted odds ratio (aOR): 1...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#17
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210826/high-acceptability-and-increased-hiv-testing-frequency-following-introduction-of-hiv-self-testing-and-network-distribution-among-south-african-msm
#18
Sheri A Lippman, Tim Lane, Oscar Rabede, Hailey Gilmore, Yea-Hung Chen, Nkuli Mlotshwa, Kabelo Maleke, Alexander Marr, James A McIntyre
BACKGROUND: South African men-who-have-sex-with-men (MSM) have a high burden of undiagnosed HIV infection and HIV-testing rates incommensurate with their risk. HIV self-testing (HIVST) may increase testing uptake, frequency, and earlier HIV detection and treatment. SETTING: Gert Sibande and Ehlanzeni districts, Mpumalanga Province, South Africa. METHODS: We conducted a longitudinal HIVST study among MSM between June 2015 - May 2017. Overall 127 HIV-negative MSM were provided with up to nine test kits of their choice - oral fluid or blood fingerstick - to use themselves and distribute to their networks...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210777/costs-and-benefits-of-on-demand-hiv-preexposure-prophylaxis-in-msm
#19
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer, Jean Michel Molina
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial, which showed the efficacy of on-demand preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-emtricitabine (FTC) in preventing HIV infection among high-risk MSM. DESIGN AND METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits, and hospital admissions were valued based on in-trial use...
January 2, 2018: AIDS
https://www.readbyqxmd.com/read/29208161/hepatitis-a-outbreak-in-hiv-infected-msm-and-in-prep-using-msm-despite-a-high-level-of-immunity-lyon-france-january-to-june-2017
#20
Caroline Charre, Christophe Ramière, Anne-Marie Roque-Afonso, Christian Chidiac, Fabien Zoulim, Matthieu Godinot, Joseph Koffi, Caroline Scholtès, Jean-Michel Livrozet, Hav Lyon Study Group, Laurent Cotte
Since 2016, an increase in the number of hepatitis A cases affecting mainly men who have sex with men (MSM) has been reported in low endemic countries in Europe. We calculated the attack rate in Lyon, France, in populations considered at high-risk: HIV-infected MSM and HIV-negative MSM receiving HIV pre-exposure prophylaxis (PrEP). In these populations, high level of immunity did not prevent the outbreak, indicating that vaccination should be reinforced, particularly in younger individuals.
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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