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https://www.readbyqxmd.com/read/29036227/evolution-of-hepatitis-a-virus-seroprevalence-among-hiv-positive-adults-in-taiwan
#1
Yu-Lin Lee, Kuan-Yin Lin, Chien-Yu Cheng, Chia-Wen Li, Chia-Jui Yang, Mao-Song Tsai, Hung-Jen Tang, Te-Yu Lin, Ning-Chi Wang, Yi-Chien Lee, Shih-Ping Lin, Yu-Shan Huang, Hsin-Yun Sun, Jun-Yu Zhang, Wen-Chien Ko, Shu-Hsing Cheng, Yuan-Ti Lee, Chun-Eng Liu, Chien-Ching Hung
OBJECTIVES: The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016. METHODS: Clinical information and data of anti-HAV antibody results were collected from 2,860 antiretroviral-naïve HIV-positive Taiwanese aged 18 years or older who initiated combination antiretroviral therapy at 11 hospitals around Taiwan between 2012 and 2016 (2012-2016 cohort)...
2017: PloS One
https://www.readbyqxmd.com/read/29035546/the-gradient-adaptive-decomposition-grad-method-optimized-refinement-along-macrostate-borders-in-markov-state-models
#2
Pablo G Romano, Marina Giuseppina Guenza
Markov State Models (MSM) are used to model the kinetics of processes sampled by Molecular Dynamics (MD) simulations. MSM reduce the high dimensionality inherent to MD simulations as they partition the free energy landscape into discrete states, generating a kinetic model as a series of uncorrelated jumps between states. Here, we detail a new method, called GRadient Adaptive Decomposition, which optimizes coarse-grained MSM by refining borders with respect to the gradient along the free energy surface. The proposed method requires only a small number of initial microstates because it corrects for errors produced by limited sampling...
October 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29031090/recreational-drug-use-and-risk-of-hiv-infection-among-men-who-have-sex-with-men-a-cross-sectional-study-in-shenzhen-china
#3
Chenlin Duan, Lan Wei, Yitian Cai, Lin Chen, Zhengrong Yang, Wei Tan, Yongxia Gan, William W Au, Jin Zhao
BACKGROUND: Recreational drug use has increased in recent years, especially among MSM, and has been found to be associated with higher risk of HIV infection. However, there is limited information about current recreational drug use among MSM in Shenzhen which is an international gateway city to China with a rapidly expanding MSM population. METHODS: A cross-sectional survey among MSM in Shenzhen was conducted and was used to collected information on demographics, sexual behavior and drug use via questionnaires...
October 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29029344/the-clinical-and-economic-impact-of-attaining-national-hiv-aids-strategy-treatment-targets-in-the-united-states
#4
Ethan D Borre, Emily P Hyle, A David Paltiel, Anne M Neilan, Paul E Sax, Kenneth A Freedberg, Milton C Weinstein, Rochelle P Walensky
Background: The US National HIV/AIDS Strategy (NHAS) aims for 72% (90% diagnosed times 80% of those virally suppressed) viral suppression among persons with human immunodeficiency virus (HIV) by 2020. We examined the clinical and economic impact of reaching this target, in the general US population and among black men who have sex with men (MSM), the group with the highest HIV prevalence. Methods: Using a mathematical simulation, we project the 5- and 20-year clinical outcomes, costs, and incremental cost-effectiveness ratios for (1) Current Pace of detection, linkage, retention, and virologic suppression and (2) NHAS investments in expanded testing ($24-$74 per test) and adherence ($400 per person-year), calibrated to achieve 72% suppression by 2020...
September 28, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028966/high-rates-of-subsequent-asymptomatic-stis-and-risky-sexual-behavior-in-patients-initially-presenting-with-primary-hiv-1-infection
#5
Dominique L Braun, Alex Marzel, Daniela Steffens, Peter W Schreiber, Christina Grube, Alexandra U Scherrer, Roger D Kouyos, Huldrych F Günthard
Introduction: Knowledge of the characteristics and risk factors of individuals with an asymptomatic sexually transmitted infection (STI) is essential for implementation of targeted STI screening strategies. Methods: Between June 2015 and January 2017 an STI screening was offered to all participants in the Zurich Primary HIV-1 Infection Study. Patients were tested for gonorrhea, chlamydia, syphilis, and hepatitis C virus. Determinants of STI prevalence and incidence were assessed using mixed-model logistic regression and survival analysis...
October 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028656/costs-and-benefits-of-on-demand-hiv-pre-exposure-prophylaxis-in-men-who-have-sex-with-men-analysis-of-the-anrs-ipergay-study-with-a-one-year-follow-up
#6
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial which showed the efficacy of on-demand pre-exposure prophylaxis (PrEP) with tenofovir-disoproxil-fumarate (TDF-FTC) in preventing HIV infection among high risk men-who have-sex-with-men (MSM). DESIGN & METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits and hospital admissions were valued based on in-trial use...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29025414/hiv-infected-men-who-have-sex-with-men-in-israel-knowledge-attitudes-and-sexual-behavior
#7
Zohar Mor, Dan Turner, Yuval Livnat, Itzchak Levy
BACKGROUND: HIV-infected (HIVI) men who have sex with men (MSM) may transmit HIV to their sero-discordant sex partner/s. This study assesses the knowledge, attitudes and sex-practices of Israeli HIVI-MSM. METHODS: This cross-sectional study compared HIVI-MSM to self-reported HIV-uninfected (HIVU) MSM by using anonymous questionnaires that were distributed in AIDS-treatment centers and gay-related internet-sites in 2015. Unprotected anal intercourse (UAI) in the last 6 months was the outcome variable...
October 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29023062/biodegradation-of-quinalphos-by-a-soil-bacterium-bacillus-subtilis
#8
Venkata Subba Reddy Gangireddygari, DileepKumar Kanderi, Ramanjaneyulu Golla, Manjunatha Bangeppagari, Vijay Anand Kumar Babu Gundi, Khayalethu Ntushelo, Rajasekhar Reddy Bontha
BACKGROUND AND OBJECTIVE: A widely used pesticide quinalphos (O, O-diethyl O-quinoxalin-2-yl phosphorothioate) may be an undesirable and persistent pollutant to non-target environments like rivers and other ecosystems. The objective of this study was to isolate a potential degradant bacterium of quinalphos from polluted soils and test its fitness under various culture conditions. MATERIALS AND METHODS: A soil bacterium strain, capable of utilizing quinalphos as its sole source of carbon and energy was isolated from soil by enrichment method on a minimal salts medium (MSM)...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022569/syphilis
#9
REVIEW
Rosanna W Peeling, David Mabey, Mary L Kamb, Xiang-Sheng Chen, Justin D Radolf, Adele S Benzaken
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. T. pallidum is renowned for its invasiveness and immune-evasiveness; its clinical manifestations result from local inflammatory responses to replicating spirochaetes and often imitate those of other diseases. The spirochaete has a long latent period during which individuals have no signs or symptoms but can remain infectious. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries...
October 12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29022544/lymphogranuloma-venereum-rates-increased-and-chlamydia-trachomatis-genotypes-changed-among-men-who-have-sex-with-men-in-sweden-2004-2016
#10
Jenny Isaksson, Ola Carlsson, Åsa Airell, Susanne Strömdahl, Göran Bratt, Björn Herrmann
This study aimed to determine the incidence of lymphogranuloma venereum (LGV) in Sweden since 2004 and to study in detail a consecutive number of Chlamydia trachomatis cases in men who have sex with men (MSM) during a 10 month period (September 2014 to July 2015). LGV increased from sporadic import cases in 2004 to comprise a spread within Sweden in 2016. Initially, only the L2b ompA genotype was detected, but in 2015 half of the genotyped LGV cases were L2 genotype. The changing genotype distribution in Sweden is linked to increased LGV spread in Europe...
October 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29021406/whole-genome-sequencing-of-neisseria-gonorrhoeae-reveals-transmission-clusters-involving-patients-of-mixed-hiv-serostatus
#11
Joanna Peters, Fiona Cresswell, Lauren Amor, Kevin Cole, Gillian Dean, Xavier Didelot, Dilrini De Silva, David W Eyre, John Paul
OBJECTIVES: Prevention and control of gonorrhoea depends on understanding the nature of sexual networks and risk factors for infection. We aimed to use high-resolution typing (whole genome sequencing (WGS)) of Neisseria gonorrhoeae isolates plus patient questionnaire data to gain insights into transmission patterns in a high prevalence setting. METHODS: During a 9-month period (July 2014-March 2015), patients diagnosed with gonorrhoea attending sexual health service in Brighton, UK, were invited to provide anonymised detailed information by questionnaire about risk factors for infection...
October 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29021132/willingness-to-use-mobile-phone-apps-for-hiv-prevention-among-men-who-have-sex-with-men-in-london-web-based-survey
#12
William C Goedel, Jason W Mitchell, Paul Krebs, Dustin T Duncan
BACKGROUND: Many men who have sex with men (MSM) use apps to connect with and meet other MSM. Given that these apps are often used to arrange sexual encounters, it is possible that apps may be suitable venues for messages and initiatives related to HIV prevention such as those to increase HIV testing rates among this population. OBJECTIVE: The purpose of this study was to assess willingness to use a new app for reminders of when to be tested for HIV infection among a sample of MSM in London who use apps to arrange sexual encounters...
October 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29020929/a-scoping-review-of-prevalence-incidence-and-risk-factors-for-hiv-infection-amongst-young-people-in-brazil
#13
Igor Pedrosa Saffier, Hélia Kawa, Guy Harling
BACKGROUND: Despite young people being a key population for HIV prevention, the HIV epidemic amongst young Brazilians is perceived to be growing. We therefore reviewed all published literature on HIV prevalence and risk factors for HIV infection amongst 10-25 year olds in Brazil. METHODS: We searched Embase, LILACS, Proquest, PsycINFO, PubMed, Scopus and Web of Science for studies published up to March 2017 and analyzed reference lists of relevant studies. We included published studies from any time in the HIV epidemic which provided estimates specific to ages 10-25 (or some subset of this age range) for Brazilians on either: (a) HIV prevalence or incidence; or (b) the association between HIV and socio-demographic or behavioral risk factors...
October 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29020194/comparison-of-measures-of-adherence-to-hiv-preexposure-prophylaxis-among-adolescent-and-young-men-who-have-sex-with-men-in-the-united-states
#14
Catherine A Koss, Sybil G Hosek, Peter Bacchetti, Peter L Anderson, Albert Y Liu, Howard Horng, Leslie Z Benet, Karen Kuncze, Alexander Louie, Parya Saberi, Craig M Wilson, Monica Gandhi
Background: Young men who have sex with men (MSM) are disproportionately impacted by HIV. Preexposure prophylaxis (PrEP) could reduce HIV acquisition among youth, but sub-optimal adherence threatens effectiveness. Optimal metrics of PrEP adherence among adolescents have not been defined. Methods: The ATN 110 and 113 studies provided daily oral PrEP with tenofovir (TFV) disoproxil fumarate/emtricitabine over 48 weeks to a diverse population of MSM (15-22 years). Self-reported adherence was assessed and PrEP drug concentrations measured from hair and dried blood spot (DBS) samples; 23% of participants received Wisepill electronic monitoring devices...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017610/hiv-among-people-who-inject-drugs-in-hungary
#15
András Ortutay, V Anna Gyarmathy, Zsuzsa Marjanek, Károly Nagy, József Rácz, István Barcs
BACKGROUND: Before 2014 (the year of closure of the two largest needle exchange programs in Hungary, which halved the number of available syringes in the country despite increased injecting risk practices) no HIV was reportedly acquired in Hungary among people who inject drugs (PWIDs) who were not also men who had sex with other men (MSM). In 2014, one and in 2015 two non-MSM PWIDs were newly diagnosed with HIV who supposedly became infected in Hungary, and both incident HIV cases in 2015 were diagnosed in the AIDS stage...
October 11, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29017552/syphilis-in-the-americas-a-protocol-for-a-systematic-review-of-syphilis-prevalence-and-incidence-in-four-high-risk-groups-1980-2016
#16
Ken Kitayama, Eddy R Segura, Jordan E Lake, Amaya G Perez-Brumer, Catherine E Oldenburg, Bethany A Myers, Paria Pourjavaheri, Chinomnso N Okorie, Robinson L Cabello, Jesse L Clark
BACKGROUND: Syphilis infection has recently resurfaced as a significant public health problem. Although there has been a tremendous amount of research on the epidemiology of syphilis, there has been limited work done to synthesize the extensive body of research and systematically estimate patterns of disease within high-risk groups in the Americas. The purpose of this systematic review and meta-analysis is to (1) summarize recent patterns of syphilis infection in North and South America among four high-risk groups (MSM, transgender women, sex workers, and incarcerated individuals) from 1980 to 2016, (2) identify and differentiate regional geographic epidemiologic characteristics, and (3) compare the epidemics of the economically developed countries of North America from the developing countries and public health systems of Latin America and the Caribbean...
October 10, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28993068/indicator-condition-based-hiv-testing-missed-opportunities-for-earlier-diagnosis-in-men-who-have-sex-with-men
#17
Marco Espinel, María José Belza, Cristina Cabeza-de-Vaca, Beatriz Arranz, Juan Miguel Guerras, Jennifer Garcia-Soltero, Juan Hoyos
INTRODUCTION: Contact with the healthcare system by a sample of seropositive men who have sex with men (MSM) prior to their HIV diagnosis are analysed, and missed opportunities (MO) for an earlier HIV diagnosis are identified. METHODOLOGY: Between 2012-2013, an online survey was conducted among HIV-positive MSM, mainly recruited from gay websites. Those who were diagnosed with HIV between 2010-2013 were analysed. MO were defined as episodes prior to the HIV diagnosis in which the healthcare system was contacted due to an indicator condition of HIV infection and the test was not suggested...
October 7, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28991027/risk-factors-for-anal-high-grade-squamous-intraepithelial-lesions-in-hiv-positive-msm-is-targeted-screening-possible
#18
Matthijs L Siegenbeek van Heukelom, Elske Marra, Henry J C de Vries, Maarten F Schim van der Loeff, Jan M Prins
OBJECTIVE: HIV-positive MSM are at increased risk for developing anal squamous cell carcinoma. Detection of precursor lesions of anal cancer [anal high-grade squamous intraepithelial lesions (HSIL)] is cumbersome and expensive. Our objective was to identify potential risk factors for anal HSIL in HIV-positive MSM to develop more stringent screening criteria. DESIGN: We studied a cohort of MSM screened by high-resolution anoscopy at three HIV clinics in Amsterdam, the Netherlands...
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28991023/pre-exposure-prophylaxis-for-msm-and-transgender-persons-in-early-adopting-countries
#19
Elske Hoornenborg, Douglas S Krakower, Maria Prins, Kenneth H Mayer
: Pre-exposure prophylaxis (PrEP) is a potent and underutilized HIV prevention tool. In this paper we review the state of knowledge regarding PrEP implementation for men who have sex with men and transgender persons in early adopting countries. We focus on implementation of PrEP in demonstration projects and clinical care, and describe the status of PrEP availability and uptake. We report on approaches to identifying appropriate PrEP candidates in real-world settings and on best practices for clinical monitoring...
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28988180/are-there-any-differences-between-different-testing-sites-a-cross-sectional-study-of-a-norwegian-low-threshold-hiv-testing-service-for-men-who-have-sex-with-men
#20
Bera Ulstein Moseng, Vegar Bjørnshagen
OBJECTIVE: To describe a Norwegian low-threshold HIV testing service targeting men who have sex with men (MSM). DESIGN AND SETTING: After the HIV testing consultation, all users of the HIV testing service were invited to answer the study questionnaire. The study setting included the sites where testing was performed, that is, the testing service's office in Oslo, cruising areas, bars/clubs and in hotels in other Norwegian cities. PARTICIPANTS: MSM users of the testing service...
October 6, 2017: BMJ Open
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