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Cronhs disease

Shivaji S Pandit, Mahesh R Kulkarni, Yashwant B Pandit, Nitin P Lad, Vijay M Khedkar
Tumor necrosis factor-α is an important pro-inflammatory cytokine having a key role in hosts defensive process of immune systems and its over expression led to a diverse range of inflammatory diseases such as Rheumatoid arthritis, Cronh's disease, psoriasis, etc. This paper describes our medicinal chemistry efforts on imidazo[1,2-b]pyridazine scaffold: design, synthesis and biological evaluation. By the introducing sulfonamide functionality at 3 positions and substituting 6 positions with (hetero)-aryl groups', a small library of compounds was prepared...
January 1, 2018: Bioorganic & Medicinal Chemistry Letters
Farid Imanzadeh, Peiman Nasri, Somayeh Sadeghi, Aliakbar Sayyari, Naghi Dara, Karimi Abdollah, Yalda Nilipoor, Mahbubeh Mansuri, Katayoon Khatami, Pejman Rouhani, Beheshteh Olang
BACKGROUND: Evidence has shown a link between allergic disease and inflammatory bowel diseases (IBDs). We investigated food allergy in Iranian pediatric IBD patients. MATERIALS AND METHODS: A cross-sectional study was conducted on a consecutive sample of children with newly diagnosed IBD referring to Mofid Children's University Hospital in Tehran (Iran) between November 2013 and March 2015. Data on age, gender, history of cow's milk allergy (CMA), IBD type, routine laboratory tests, and colonoscopic and histopathological findings were gathered...
September 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Maria Angeles Rosillo, Marina Sánchez-Hidalgo, Ana Cárdeno, Marina Aparicio-Soto, Susana Sánchez-Fidalgo, Isabel Villegas, Catalina Alarcón de la Lastra
Dietary polyphenols present in Punica granatum (pomegranate), such as ellagitannins and ellagic acid (EA) have shown to exert anti-inflammatory and antioxidant properties. This study was designed to evaluate the effects of a dietary EA-enriched pomegranate extract (PE) in a murine chronic model of Cronh's disease (CD). Colonic injury was induced by intracolonic instillation of trinitrobenzensulfonic acid (TNBS). Rats were fed with different diets during 30 days before TNBS instillation and 2 weeks before killing: (i) standard, (ii) PE 250 mg/kg/day, (iii) PE 500 mg/kg/day, (iv) EA 10 mg/kg/day and (v) EA 10 mg/kg/day enriched-PE 250 mg/kg/day...
September 2012: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Seong Joo Kang, Won Moon, Moo In Park, Kyu Jong Kim, Jong Bin Kim, Mi Jung Park, Seun Ja Park, Hee Kyung Chang
Erythema nodosum is the most common form of septal panniculitis and the most frequent skin manifestation associated with inflammatory bowel disease, affecting up to 15% of Crohn's disease patients. Since the development of erythema nodosum is closely related with a variety of disorders and condition, it can serve as an important early sign of systemic disease. Here, we present the occurrence of erythema nodosum as an early sign of Cronh's disease in a 16-year-old woman.
December 2011: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Eduardo Redondo-Cerezo
Capsule endoscopy (CE) offers state-of-the-art imaging of the small bowel. In Crohn's disease its clinical role is still uncertain. This report analyses the usefulness of CE in patients with suspected Cronh's disease, in patients with established Crohn's disease (when assessing severity, occult gastrointestinal bleeding and/or as a guide to therapy), in patients with inflammatory bowel disease unclassified (IBDU), and in individuals with ulcerative colitis. The first item in this group is the most important although there is no strong evidence to establish the position of CE in the diagnostic workup...
May 16, 2010: World Journal of Gastrointestinal Endoscopy
M R Lozyns'ka
Cytogenetical study ofcolorectal polyps of different histological structures from 54 patients has been carried out. Domination of diploid karyotypes was shown. Abnormal karyotypes were found in 17 (31,5%) polyps: the most frequent anomalies were in adenoma while in hamartomatous polyps they were absent. The typical features of the karyotypes were numeric changes, such as additional copies of chromosomes 13, 7, 20, 18, 16 in some combinations. The polyps with high-grade dysplasia in all cases had abnormal karyotypes...
November 2008: T︠S︡itologii︠a︡ i Genetika
Hye Jeong Park, Yong Cheol Jeon, Kyeonga Lee, Tae Jun Byun, Tae Yeob Kim, Chang Soo Eun, Dong Soo Han, Joo Hyun Sohn
A psoas abscess (PA) is a rare clinical entity but is potentially serious condition which presents diagnostic and therapeutic challenges. The diagnosis is frequently delayed due to its variable and nonspecific features and occult clinical course. The delay in diagnosis and treatment of PA is the major poor prognostic factor. We describe herein a case of the sterile psoas abscess complicating Cronh's disease which presented as hip flexion contracture. A 29-year-old man, at remission stage of CD involving ileocolic segment, was admitted due to pain from hip contracture...
September 2008: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
D Carrera, A Domenech, J Mora, R Ballester, M Roca, R I Jiménez, B Verdura, C Baliellas, J Guardiola, J Martín-Comín
OBJECTIVE: The inflammatory bowel disease (EII) has a chronic evolution with a frequent relapses. There is no specific diagnosis method to detect the patients with a high risk to relapse. The aim of the work was to analyse the prognostic value of 99mTc-HMPAO leukocyte scintigraphy (LS) performed during an acute attack of EII. MATERIAL AND METHODS: 18 patients (mean age 32 +/- 10 years) admitted for an acute attack of EII has been prospectively studied (5 ulcerative colitis [UC] and 13 Cronh's disease [CD]), excluding patient with prior steroids or immunosuppressive therapy during the last year...
November 2006: Revista Española de Medicina Nuclear
N Iu Petukhova
The paper deals with the capacities of X-ray diagnosis of Cronh's disease involving the small bowel, using the barium contract agent Entero-VU specially designed to examine the bowel. It describes 3 cases of Crohn's disease presented by its different stages and localization in the small bowel. In the author's opinion, the barium contrast agent Entero-VU designed to examine the small bowel has two basic advantages: it is easy-to-use and highly diagnostically effective.
September 2005: Vestnik Rentgenologii i Radiologii
R W Ammann, J Müller-Schoop, M Knoblauch
9 patients with acute exacerbations of Crohn's disease were treated over 2.5 months or longer with ornidazole (nitroimidazole). While 3 patients showed no response at all to 5 cycles of ornidazole treatment, 6 patients improved markedly within 2-3 months. In all but 1 patient, the improvement lasted during long-term therapy (average 9 months). Therapy was discontinued in 5 of these patients after 2.5-14 months; 2 patients had severe recurrences within 2-10 weeks, while 3 patients remained well during the follow-up (average 4...
July 15, 1978: Schweizerische Medizinische Wochenschrift
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