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Cross reactive nsaids

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https://www.readbyqxmd.com/read/27041368/fixed-drug-eruption-due-to-selective-hypersensitivity-to-naproxen-with-tolerance-to-other-propionic-acid-nsaids
#1
Blanca Noguerado-Mellado, Abdonias Rodriguez Gamboa, Patricia Rojas Perez-Ezquerra, Cristina Morales Cabeza, Roberto Pelta Fernandez, Manuel De Barrio Fernandez
BACKGROUND: Naproxen is a non-steroidal anti-inflammatory drug (NSAID), belonging to propionic acid group, and its chemical structure is a 6-metoxi-metil-2-naftalenoacetic acid. Fixed drug eruptions (FDE) have been rarely reported. OBJECTIVE: A 38-year-old woman referred that after 2 hours of taking 2 tablets of naproxen for a headache, she developed several edematous and dusky-red macules, one on right forearm and the other two in both thighs and she was diagnosed with FDE probably due to naproxen...
April 4, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27030979/what-we-know-about-nonsteroidal-anti-inflammatory-drug-hypersensitivity
#2
REVIEW
Duy Le Pham, Ji-Hye Kim, Tu Hoang Kim Trinh, Hae-Sim Park
Nonsteroidal anti-inf lammatory drugs (NSAIDs) are widely prescribed for the treatment of inflammatory diseases, but their use is frequently related to hypersensitivity reactions. This review outlines our current knowledge of NSAID hypersensitivity (NHS) with regard to its pathogenic, molecular, and genetic mechanisms, as well as diagnosis and treatment. The presentation of NHS varies from a local (skin and/or airways) reaction to systemic reactions, including anaphylaxis. At the molecular level, NHS reactions can be classified as cross-reactive (mediated by cyclooxygenase inhibition) or selective (specific activation of immunoglobulin E antibodies or T cells)...
May 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26841325/immediate-hypersensitivity-reactions-to-ibuprofen-and-other-arylpropionic-acid-derivatives
#3
N Blanca-López, D Pérez-Alzate, I Andreu, I Doña, J A Agúndez, E García-Martín, M Salas, M Á Miranda, M J Torres, J A Cornejo-García, M Blanca, G Canto
BACKGROUND: Although ibuprofen and other arylpropionic acid derivatives (APs) are the most common medicines involved in hypersensitivity drug reactions (HDRs) to NSAIDs, no patient series studies have been performed regarding immediate selective reactions (SRs) to these drugs. OBJECTIVE: To characterize patients with immediate selective HDRs to ibuprofen and other APs through clinical history and challenge. METHODS: Subjects who developed an HDR to APs less than 1 h after drug intake were included...
July 2016: Allergy
https://www.readbyqxmd.com/read/26681230/associations-between-spondyloarthritis-features-and-magnetic-resonance-imaging-findings-a-cross-sectional-analysis-of-1-020-patients-with-persistent-low-back-pain
#4
Bodil Arnbak, Anne Grethe Jurik, Kim Hørslev-Petersen, Oliver Hendricks, Louise Thuesen Hermansen, Anne Gitte Loft, Mikkel Østergaard, Susanne Juhl Pedersen, Anna Zejden, Niels Egund, René Holst, Claus Manniche, Tue Secher Jensen
OBJECTIVE: The Assessment of SpondyloArthritis international Society (ASAS) has previously published criteria for spondyloarthritis (SpA). In the Spines of Southern Denmark cohort, which included patients with persistent low back pain and an unknown proportion of patients with SpA, our objectives were 1) to estimate the prevalence of magnetic resonance imaging (MRI) findings and clinical features included in the ASAS criteria for SpA and 2) to explore the associations between MRI findings and clinical features...
April 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26439474/rapid-analysis-of-diclofenac-in-freshwater-and-wastewater-by-a-monoclonal-antibody-based-highly-sensitive-elisa
#5
Maria Huebner, Ekkehard Weber, Reinhard Niessner, Souhir Boujday, Dietmar Knopp
The non-steroidal anti-inflammatory drug (NSAID) diclofenac (DCF) is found worldwide in the aqueous environment. Therefore, it has raised increased public concern on potential long-term impact on human health and wildlife. The importance of DCF has been emphasized by the European Union recently by including this pharmaceutical in the first watch list of priority hazardous substances in order to gather Union-wide monitoring data. Rapid and cheap methods of analysis are therefore required for fresh and wastewater monitoring with high sample load...
November 2015: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26351533/acute-anterior-uveitis-and-other-extra-articular-manifestations-of-spondyloarthritis
#6
T C Mitulescu, C Popescu, A Naie, D Predeţeanu, V Popescu, C Alexandrescu, L M Voinea
BACKGROUND: Spondyloarthritis (SpA) is associated with an array of peripheral manifestations. Our study aims to evaluate extra-articular manifestations of SpA in a Romanian academic clinical setting and to observe their associations with different disease measures. METHODS: The study was designed to note the extra-articular manifestations of SpA patients in a cross-sectional and retrospective manner. Records included demographics, inflammation markers, SpA clinical characteristics, treatment regimes, associated osteoporosis and cardiovascular morbidity...
July 2015: Journal of Medicine and Life
https://www.readbyqxmd.com/read/26315297/different-phenotypes-of-non-steroidal-anti-inflammatory-drug-hypersensitivity-during-childhood
#7
Ozlem Cavkaytar, Ebru Arik Yilmaz, Betul Karaatmaca, Betul Buyuktiryaki, Cansın Sackesen, Bulent E Sekerel, Ozge Soyer
BACKGROUND: Although non-steroidal anti-inflammatory drug hypersensitivity (NSAID-H) has been widely studied in adults, there is still a lack of data regarding the features and phenotypes of NSAID-H in children. Our aim was to define risk factors and different phenotypes according to clinical patterns. METHODS: Patients with a history of reaction to any NSAIDs referred between January 2012 and October 2014 were included. After completing a European Network for Drug Allergy (ENDA) questionnaire, initial skin and/or oral provocation tests (OPTs) were performed for the offending drug...
2015: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/26314820/nonsteroidal-anti-inflammatory-drug-hypersensitivity-among-children
#8
Hakan Guvenir, Emine Dibek Misirlioglu, Emine Vezir, Muge Toyran, Tayfur Ginis, Ersoy Civelek, Can N Kocabas
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) are the second-most frequent drugs that cause hypersensitivity reactions among children. Studies related to NSAIDs hypersensitivity in children are limited. In this study, we aimed to evaluate children admitted with suspicion of NSAIDs reaction. METHOD: Between January 1, 2011, and November 30, 2014, we included patients with suspicion of NSAIDs hypersensitivity in our clinic. For evaluation, skin tests and oral provocation tests with the drug (suspected or alternative) were proposed...
September 2015: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/26254051/approaches-to-the-diagnosis-and-management-of-patients-with-a-history-of-nonsteroidal-anti-inflammatory-drug-related-urticaria-and-angioedema
#9
REVIEW
Marek L Kowalski, Katharine Woessner, Marek Sanak
Nonsteroidal anti-inflammatory drug (NSAID)-induced urticarial and angioedema reactions are among the most commonly encountered drug hypersensitivity reactions in clinical practice. Three major clinical phenotypes of NSAID-induced acute skin reactions manifesting with angioedema, urticaria, or both have been distinguished: NSAID-exacerbated cutaneous disease, nonsteroidal anti-inflammatory drug-induced urticaria/angioedema (NIUA), and single NSAID-induced urticaria and angioedema. In some patients clinical history alone might be sufficient to establish the diagnosis of a specific type of NSAID hypersensitivity, whereas in other cases oral provocation challenges are necessary to confirm the diagnosis...
August 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26211456/evaluation-of-bone-mass-in-children-and-young-adults-with-juvenile-idiopathic-arthritis
#10
Tingting Tang, Xuemei Tang, Li Xu, Yingbo Huang, Jie Zeng, Qiu Li
OBJECTIVES: To examine bone mineral density (BMD) in the spines of patients with juvenile idiopathic arthritis (JIA), and to identify the main predictors of spine BMD. METHODS: 160 patients with JIA (82 female, 78 male; median age, 8.7±3.9 years (range, 2.2-18.2 years)) who fulfilled the International League of Associations for Rheumatology (ILAR) criteria were enrolled. All subjects underwent an initial dual energy x-ray absorptiometry (DXA) scan of the lumbar spine, while 114 and 87 patients underwent a second and third scan, respectively...
September 2015: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26173603/evaluation-of-hypersensitivity-reactions-to-nonsteroidal-anti-inflammatory-drugs-according-to-the-latest-classification
#11
S Demir, M Olgac, D Unal, A Gelincik, B Colakoglu, S Buyukozturk
BACKGROUND/AIM: The consensus document for hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) proposed by the European Network for Drug Allergy (ENDA) interest group (2011) was revised in 2013. We aimed to evaluate the usability of the latest NSAID hypersensitivity classification of ENDA. METHOD: A total of 370 patients with a history of hypersensitivity reactions to NSAIDs among the 1250 outpatients referred for suspected drug allergy between July 2013 and June 2014 were evaluated, and 308 patients who were confirmed as having NSAID hypersensitivity were included in this study...
November 2015: Allergy
https://www.readbyqxmd.com/read/25774061/tenascin-c-levels-a-toll-like-receptor-4-ligand-in-enthesitis-related-arthritis-category-of-juvenile-idiopathic-arthritis-a-cross-sectional-and-longitudinal-study
#12
Anuj Shukla, Priyanka Gaur, Amita Aggarwal
OBJECTIVE: Monocytes of children with enthesitis-related arthritis (ERA) show Toll-like receptor 4 (TLR4) overexpression. Tenascin-C (TNC) is an extracellular matrix glycoprotein and acts as an endogenous TLR4 ligand. Thus, we studied the serum and synovial fluid (SF) levels of TNC in children with ERA. METHODS: TNC was measured in the serum of 80 children with ERA satisfying the International League of Associations for Rheumatology criteria. Fifteen children were followed up while being treated with regular nonsteroidal antiinflammatory drug (NSAID) therapy and levels were reassessed at 3 months...
May 2015: Journal of Rheumatology
https://www.readbyqxmd.com/read/25763179/hypersensitivity-to-non-steroidal-anti-inflammatory-drugs-nsaids-classification-of-a-danish-patient-cohort-according-to-eaaci-enda-guidelines
#13
Christoffer V Nissen, Carsten Bindslev-Jensen, Charlotte G Mortz
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA(2)LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system. METHODS: Patients with a clinical history of NSAID hypersensitivity referred to the Allergy Centre, Odense University Hospital between 2002 and 2011 and evaluated with oral provocation tests (OPTs) were included in the study...
2015: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/24634525/safety-of-5-aminosalicylic-acid-derivatives-in-patients-with-sensitivity-to-acetylsalicylic-acid-and-nonsteroidal-anti-inflammatory-drugs
#14
REVIEW
Jennifer Poh, Sandra Knowles
BACKGROUND: One of the cornerstones of the management of inflammatory bowel disease is the use of 5-aminosalicylic acid (5-ASA) compounds for treatment of flares and as maintenance therapy during remission. There are concerns about using 5-ASA in patients with a history of hypersensitivity to acetylsalicylic acid (ASA). OBJECTIVE: To assess the literature with respect to the safety of 5-ASA compounds in patients with documented sensitivity to ASA or nonsteroidal anti-inflammatory drugs (NSAIDs)...
January 2014: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/24587953/cross-reactivity-to-acetaminophen-and-celecoxib-according-to-the-type-of-nonsteroidal-anti-inflammatory-drug-hypersensitivity
#15
Yoon-Jeong Kim, Kyung-Hwan Lim, Mi-Young Kim, Eun-Jung Jo, Suh-Young Lee, Seung-Eun Lee, Min-Suk Yang, Woo-Jung Song, Hye-Ryun Kang, Heung-Woo Park, Yoon-Seok Chang, Sang-Heon Cho, Kyung-Up Min, Sae-Hoon Kim
PURPOSE: Identification of tolerable alternative analgesics is crucial for management in nonsteroidal anti-inflammatory drug (NSAID)-sensitive patients. We investigated cross-reactivity of acetaminophen and celecoxib according to the type of aspirin/NSAID hypersensitivity and aimed to determine the risk factors for cross-intolerance. METHODS: We retrospectively reviewed the medical records of patients intolerant to aspirin and NSAIDs who had undergone an acetaminophen and/or celecoxib oral provocation test...
March 2014: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/24472266/celecoxib-a-selective-cyclooxygenase-2-inhibitor-reduces-level-of-a-bone-resorption-marker-in-postmenopausal-women-with-rheumatoid-arthritis
#16
Shigeyoshi Tsuji, Tetsuya Tomita, Takanobu Nakase, Masayuki Hamada, Hideo Kawai, Hideki Yoshikawa
AIM: Celecoxib (CEL), a selective cyclooxygenase-2 (COX-2) inhibitor, has been reported to suppress osteoclastogenesis in vitro, reduce levels of bone resorption markers in ovariectomized (OVX) mice, and prevent bone destruction in rheumatoid arthritis (RA) model mice; however, no clinical data has been reported. Here, we prospectively evaluated the changes in bone turnover markers in RA patients who switched from nonsteroidal anti-inflammatory drugs (NSAIDs) to CEL, to examine the effects of selective COX-2 inhibitor on bone metabolism...
January 2014: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/24117618/challenge-proven-nonsteroidal-anti-inflammatory-drug-hypersensitivity-in-children
#17
O Yilmaz, I H Ertoy Karagol, A Bakirtas, E Topal, G E Celik, M S Demirsoy, I Turktas
BACKGROUND: Few studies investigated hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) in children. The objective was to determine the frequency of true NSAID hypersensitivity (NSAID-H) and whether there were any parameters in the history of children that would predict NSAID-H. Secondly, an investigation was conducted into whether NSAID-hypersensitive children could tolerate safe alternatives. Differing from previous studies, the researchers followed the recent diagnostic algorithm proposed for acute reactions in NSAID-H...
December 2013: Allergy
https://www.readbyqxmd.com/read/24000661/-coxibs-for-postoperative-analgesia
#18
REVIEW
A G Voloshin, V V Nikoda
Coxibs can be regarded as an effective way of postoperative pain treatment with proven analgesic and opioid-saving effects. When comparing the opioid-saving effect after the large surgical interventions, COX-2 inhibitors are not inferior to NSAIDs and surpass paracetamol. The combination of coxibs and opiate receptors antagonists, as well as epidural analgesia is effective in the frames of multimodal analgesia. The reasonability of coxibs and paracetamol combination is questionable. In patients at risk of gastrointestinal complications development, but with none cardiovascular risk, COX-2 inhibitors are more safe, than the combination of NSAIDs and proton pump inhibitors...
March 2013: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/23750456/time-resolved-spectroscopic-characterization-of-a-novel-photodecarboxylation-reaction-mediated-by-homolysis-of-a-carbon-%C3%AE-bond-in-flurbiprofen
#19
Tao Su, Jiani Ma, Naikei Wong, David Lee Phillips
Flurbiprofen (Fp), a nonsteroidal anti-inflammatory drug (NSAID) currently in use for arthritis pain relief and in clinical trials for metastatic prostate cancer, can induce photosensitization and phototoxicity upon exposure to sunlight. The mechanisms responsible for Fp phototoxicity are poorly understood and deserve investigation. In this study, the photodecarboxylation reaction of Fp, which has been assumed to underpin its photoinduced side effects, was explored by femtosecond transient absorption (fs-TA), nanosecond transient absorption (ns-TA), and nanosecond time-resolved resonance Raman (ns-TR(3)) spectroscopic techniques in pure acetonitrile (MeCN) solvent...
July 18, 2013: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/23491990/akutes-nierenversagen-%C3%A2-ein-geschenk-einer-freundin%C3%A2
#20
Buylaert, Schifferli
Acute allergic interstitial nephritis (AIN) due to non-steroidal anti-inflammatory drugs (NSAID) is a well known but rare adverse drug event. Here, we describe the case of a 70 year old woman with recurrent episodes of acute renal failure. A first episode of (AIN) occurred after the intake of mefenaminic acid tablets. A second episode of AIN occurred two years later, this time after transdermal application of diclofenac. Our case illustrates cross-reactivity between NSAIDs and shows that transdermally applicated medication can cause systemic adverse events as well...
December 1, 2004: Therapeutische Umschau. Revue Thérapeutique
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