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Nonsteroidal hypersensitivity

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https://www.readbyqxmd.com/read/29590651/the-frequency-of-nonsteroidal-anti-inflammatory-drug-hypersensitivity-in-children-with-asthma
#1
Hakan Guvenir, Emine Dibek Misirlioglu, Murat Capanoglu, Betul Buyuktiryaki, Zeynep Reyhan Onay, Tayfur Ginis, Muge Toyran, Ersoy Civelek, Can Naci Kocabas
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the second-most frequent drug type to cause hypersensitivity reactions in children. Asthma is one of the risk factors for NSAID hypersensitivity (NSAID-H) in adult patients. There are limited number of studies evaluating NSAID-H among children with asthma. Our aim was to assess the frequency of confirmed NSAID-H and evaluate the classification of NSAID-H in children with asthma. METHODS: Patients followed with a diagnosis of asthma in our Pediatric Allergy Clinic were evaluated for NSAID-H...
March 28, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29569284/low-frequency-of-acetyl-salicylic-acid-hypersensitivity-in-mastocytosis-the-results-of-a-double-blind-placebo-controlled-challenge-study
#2
M A W Hermans, S Q A van der Vet, P M van Hagen, R Gerth van Wijk, P L A van Daele
BACKGROUND: Patients with mastocytosis are at increased risk of anaphylaxis. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is often discouraged because of this reason. However, the actual prevalence and severity of NSAID-related hypersensitivity among patients with mastocytosis is unknown. METHODS: A double-blind, placebo-controlled acetylsalicylic acid (ASA) challenge up to a cumulative dose of 520 mg was performed among adult patients with mastocytosis...
March 22, 2018: Allergy
https://www.readbyqxmd.com/read/29568997/-severe-skin-reactions-due-to-new-medications
#3
REVIEW
M Mockenhaupt, M Paulmann
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and a specific form of hypersensitivity syndrome which is nowadays called "drug reaction with eosinophilia and systemic symptoms" (DRESS) are severe, mainly drug-induced skin reactions. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as drug reaction, in total only about three quarters of the cases are actually caused by drugs...
April 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29553115/-a-case-of-a-child-diagnosed-as-hypersensitivity-reactions-to-nonsteroidal-anti-inflammatory-drugs-after-onset-of-oral-mite-anaphylaxis
#4
Machiko Usui, Masayuki Akashi
Oral mite anaphylaxis (OMA) caused by mite-containing food that was initially reported in 1993 has become commonly known after accumulating the case reports. Although it has been pointed out as being related to aspirin intolerance overseas, there are only a few cases reported in Japan so far, particularly no case for children. We report a child case which is seemingly related to OMA and aspirin intolerance. The case is for a boy at the age of 10. After eating Takoyaki with the ingredient of mite-containing flour, he was diagnosed as OMA due to the occurrence of anaphylaxis with respiratory discomfort, abdominal pain, and vomiting...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29515006/nonsteroidal-anti-inflammatory-drug-hypersensitivity-not-always-an-allergy
#5
M A W Hermans, R Otten, A F Karim, M S van Maaren
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a major cause of hypersensitivity reactions. Several distinct clinical syndromes are described regarding NSAID hypersensitivity. Such a reaction is generally caused by a non-immunological mechanism. In susceptible patients, COX-1 inhibition leads to an imbalance in lipid mediators such as leukotrienes and prostaglandins. It is essential to distinguish multiple nonspecific NSAID hypersensitivity from single NSAID hypersensitivity, since the management of these respective syndromes is essentially different...
March 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29496464/bronchiectasis-in-severe-asthma-clinical-features-and-outcomes
#6
Isabel Coman, Beatriz Pola-Bibián, Pilar Barranco, Gemma Vila-Nadal, Javier Dominguez-Ortega, David Romero, Carlos Villasante, Santiago Quirce
BACKGROUND: Bronchiectasis are increasingly identified in subjects with severe asthma and could contribute to disease severity. OBJECTIVE: We aimed to determine the prevalence of bronchiectasis in our population of subjects with severe asthma and to better characterize the clinical features of these patients and their outcomes. METHODS: We retrospectively reviewed the medical files of 184 subjects with confirmed severe asthma who had undergone a high resolution thoracic computed tomography and compared the characteristics and outcomes of subjects with and without bronchiectasis...
February 26, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29414455/aspirin-exacerbated-respiratory-disease-current-topics-and-trends
#7
REVIEW
José Carlos Rodríguez-Jiménez, Fernanda Judith Moreno-Paz, Luis Manuel Terán, Eduardo Guaní-Guerra
Aspirin-exacerbated respiratory disease is a chronic and treatment-resistant disease, characterized by the presence of eosinophilic rhinosinusitis, nasal polyposis, bronchial asthma, and nonsteroidal anti-inflammatory drugs hypersensitivity. Alterations in arachidonic acid metabolism may induce an imbalance between pro-inflammatory and anti-inflammatory substances, expressed as an overproduction of cysteinyl leukotrienes and an underproduction of prostaglandin E2. Although eosinophils play a key role, recent studies have shown the importance of other cells and molecules in the development of the disease like mast cells, basophils, lymphocytes, platelets, neutrophils, macrophages, epithelial respiratory cells, IL-33 and thymic stromal lymphopoietin, making each of them promissory diagnostic and treatment targets...
February 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29404165/clinical-and-serological-features-of-eosinophilic-and-vasculitic-phases-of-eosinophilic-granulomatosis-with-poliangiitis-a-case-series-of-15-patients
#8
İnsu Yılmaz, Nuri Tutar, Zuhal Özer Şimşek, Fatma Sema Oymak, İnci Gülmez
OBJECTIVES: Eosinophilic granulomatosis with poliangiitis (EGPA) which was previously called Churg-Strauss Syndrome, is classified into eosinophilic and vasculitic phases. To characterize the eosinophilic and vasculitic phases of the disease in terms of clinical findings, serology, and treatment. MATERIALS AND METHODS: We included 15 EGPA patients in the study. The clinical, serological, and therapeutic characteristics and the treatment responses of the patients were recorded...
July 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29393216/establishing-a-safe-administration-of-asa-in-cardiovascular-patients-with-nonsteroidal-anti-inflammatory-drug-hypersensitivity-with-skin-and-or-respiratory-involvement
#9
Mona Al-Ahmad, Tito Rodriguez-Bouza, Midhat Nurkic
BACKGROUND: A history of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with cross-intolerance to several drugs is common in some patients with coronary artery disease. We present a series of patients with acute coronary syndrome undergoing ASA desensitization prior to a possible stent to evaluate the short- and long-term efficacy and safety. The aim was to evaluate the outcomes of an ASA desensitization protocol developed by our center based on the guidelines proposed by the EAACI drug allergy expert recommendations...
January 26, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29384107/restoration-of-aspirin-tolerance-following-omalizumab-treatment-in-a-patient-with-chronic-spontaneous-urticaria
#10
R Asero
Up to 30% of cases of chronic spontaneous urticaria (CSU) are exacerbated by COX-1 inhibit-ing nonsteroidal anti-inflammatory drugs (NSAID); this clinical picture is termed NECD (NSAID-exacerbated cutaneous disease). On the other hand, multiple NSAID hypersensitivity may occur in the absence of an underlying CSU also, a situation that is termed NIUA (NSAID-induced urticaria / angioedema). The present study reports a case of multiple NSAID hypersensitivity that occurred in a man much before he developed severe CSU...
November 30, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29199960/update-on-the-genetic-basis-of-drug-hypersensitivity-reactions
#11
REVIEW
R Jurado-Escobar, J R Perkins, E García-Martín, M Isidoro-García, I Doña, M J Torres, J A Cornejo-García
Drug hypersensitivity reactions (DHRs) are unpredictable, complex responses to medicines in predisposed individuals. They represent a major health problem owing to the number of patients affected and the severity of the clinical conditions they can induce. In addition to environmental factors, the underlying mechanisms of DHRs are also influenced by genetic factors, although considerable gaps remain in our knowledge. Therefore, further study of the genetics of DHRs is necessary to shed light on their underlying mechanisms...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29066931/the-safety-profile-of-parecoxib-for-the-treatment-of-postoperative-pain-a-pooled-analysis-of-28-randomized-double-blind-placebo-controlled-clinical-trials-and-a-review-of-over-10-years-of-postauthorization-data
#12
Stephan A Schug, Bruce Parsons, Chunming Li, Feng Xia
BACKGROUND: Nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors are associated with safety issues including cardiovascular, renal, and gastrointestinal (GI) events. OBJECTIVE: To examine the safety of parecoxib, a COX-2 inhibitor, for the management of postoperative pain. DESIGN: Pooled analysis of 28 placebo-controlled trials of parecoxib and review of postauthorization safety data...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28986120/acetyl-salicylic-acid-challenge-in-children-with-hypersensitivity-reactions-to-nonsteroidal-anti-inflammatory-drugs-differentiates-between-cross-intolerant-and-selective-responders
#13
Natalia Blanca-López, Elisa Haroun-Diaz, Francisco Javier Ruano, Diana Pérez-Alzate, María Luisa Somoza, María Vázquez de la Torre Gaspar, Francisco Rivas-Ruiz, Elena García-Martin, Miguel Blanca, Gabriela Canto
BACKGROUND: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in children are becoming a great concern. Most studies have focused on adults, with noted discrepancies observed in the classification of hypersensitivity reactions to NSAIDs in children when compared with adults. OBJECTIVE: To phenotype a group of children with hypersensitivity reactions to NSAIDs, including paracetamol, and analyze the degree of agreement with the entities reported in adults and how they fit the proposed classifications...
October 3, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28965637/aspirin-and-nonsteroidal-antiinflammatory-drugs-hypersensitivity-and-management
#14
REVIEW
Brian Modena, Andrew A White, Katharine M Woessner
Aspirin and nonsteroidal antiinflammatory drugs (NSAIDs) are widely used in the United States and throughout the world for a variety of indications. Several unique hypersensitivity syndromes exist to this class of medications, making them one of the common reasons for consultation to the allergist. The lack of any laboratory-based diagnostic studies to assist in identifying the culprits in these reactions make evaluation of aspirin and NSAID hypersensitivity challenging. Identifying patients appropriate for oral challenge and/or desensitization protocols is the standard pragmatic approach to this issue when it arises...
November 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28814352/characteristics-of-drug-induced-anaphylaxis-in-children-and-adolescents
#15
Ozlem Cavkaytar, Betül Karaatmaca, Pınar Gur Cetinkaya, Saliha Esenboga, Ebru Arik Yilmaz, Umit M Sahiner, Bulent E Sekerel, Ozge Soyer
BACKGROUND: Although data on anaphylaxis in the general population exist for different allergens, there is still lack of detailed etiologic data on drug-induced anaphylaxis (DIA), particularly in children. OBJECTIVE: To define the etiology of DIA, to determine the accuracy of drug-related anaphylaxis histories, along with the severity and culprit drug associations among individuals <18 years old. METHODS: Patients with a history of drug hypersensitivity reaction (DHR) referred to our center between January 2012 and February 2016 were included...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28765820/self-report-prevalence-and-associated-factors-to-drug-hypersensitivity-in-mexican-young-adults
#16
Martín Bedolla-Barajas, Cecilia Puente-Fernández, Miriam V Flores-Merino, Jaime Morales-Romero, Ma Victoria Domínguez-García
BACKGROUND: Drug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system. Epidemiological data related to drug hypersensitivity reactions in our country are scarce. OBJECTIVE: To determine the prevalence of drug hypersensitivity in a group of young adults, as well as to identify associated factors. METHODS: A structured questionnaire was applied to young people aged 18 to 25 years...
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28750137/polymorphism-of-il10-il4-ctla4-and-dao-genes-in-cross-reactive-nonsteroidal-anti-inflammatory-drug-hypersensitivity
#17
Luciana Mabel Ferreira Vasconcelos, Raphael de Oliveira Rodrigues, Andressa Almeida Albuquerque, Gabrielle Dantheias Barroso, Greyce Luri Sasahara, Janaira Fernandes Severo Ferreira, Eudiana Vale Francelino, Cynthia Chester Cardoso, Silvia Helena Barem Rabenhorst, Thereza Lúcia Prata de Almeida, Aparecida Tiemi Nagao-Dias
Our aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (-1082 G>A), IL4 (-589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction fragment length polymorphism technique. With regard to the polymorphism at IL10 -1082, higher frequencies of the AG genotype (57% vs 39%) and G allele carriers (70% vs 48%) were found among the patients, indicating a risk effect (odds ratio [OR] = 2...
January 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28704185/phenotypes-determined-by-cluster-analysis-in-moderate-to-severe-bronchial-asthma
#18
Vania M Youroukova, Denitsa G Dimitrova, Anna D Valerieva, Spaska S Lesichkova, Tsvetelina V Velikova, Ekaterina I Ivanova-Todorova, Kalina D Tumangelova-Yuzeir
BACKGROUND: Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms. AIM: To identify phenotypes using cluster analysis in moderate to severe bronchial asthma and to compare differences in clinical, physiological, immunological and inflammatory data between the clusters. PATIENTS AND METHODS: Forty adult patients with moderate to severe bronchial asthma out of exacerbation were included...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28590311/aspirin-challenge-and-desensitization-how-when-and-why
#19
Gabriele Cortellini, Cristiano Caruso, Antonino Romano
PURPOSE OF REVIEW: To investigate the current approach to aspirin challenge (drug provocation) and/or desensitization in patients with histories of hypersensitivity reactions to it, particularly in those with cardiovascular diseases. RECENT FINDINGS: The literature indicates that patients with coronary artery disease (CAD), including those with an acute coronary syndrome, may safely undergo low-dose aspirin challenge and/or desensitization. Recently, flowcharts regarding challenge/desensitization procedures with aspirin in patients with CAD and histories of aspirin hypersensitivity reactions have become available...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28483309/current-knowledge-and-management-of-hypersensitivity-to-aspirin-and-nsaids
#20
Tanya M Laidlaw, Katherine N Cahill
Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most common culprits of drug-induced hypersensitivity reactions, and can lead to a wide array of adverse effects. The accurate and timely diagnosis of aspirin and NSAID-induced hypersensitivity reactions is important for both patient safety and for the initiation of appropriate disease-specific management and treatment. Because there are no reliably validated in vitro tests available, aspirin and NSAID challenges are considered to be the criterion standard for the diagnosis of these hypersensitivity reactions, though in some patients the diagnosis can be made on the basis of a clear clinical history...
May 2017: Journal of Allergy and Clinical Immunology in Practice
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