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https://www.readbyqxmd.com/read/29343895/why-borrow-from-peter-when-paul-can-afford-it-reverse-homodigital-artery-flap-for-fingertip-reconstruction
#1
Narayanamurthy Sundaramurthy, Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj
Background: Fingertip injuries that are complicated by pulp loss, bone or tendon exposure will need a flap cover. Cross finger flap is commonly used to cover such defects. However, patients are apprehensive about injuring the uninjured finger as a donor site. Reverse homodigital artery flap (RHAF) can provide reliable vascularised cover to such defects. Aims: This study aims to assess the functional and aesthetic outcomes along with the patient satisfaction of RHAFs done for fingertip defects...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29341373/antibiotic-allergy-labels-the-impact-of-taking-a-clinical-history
#2
Adrienne Torda, Victor Chan
BACKGROUND: Many patients admitted to hospital have an antibiotic allergy (AAL) documented in their medical record. In many of these, the reaction is not a hypersensitivity reaction or may no longer be relevant. Despite this, the label adversely affects patient care directly in terms of antibiotic selection, and indirectly in terms of patient costs and the development of antimicrobial resistance. AIMS: To estimate the prevalence of AALs in a cohort of hospitalised patients, to investigate the feasibility of de-labelling through re-challenge based solely upon clinical grounds...
January 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29336544/identification-of-collateral-sensitivity-to-dihydroorotate-dehydrogenase-inhibitors-in-i-plasmodium-falciparum-i
#3
Leila Saxby Ross, Maria Jose Lafuente-Monasterio, Tomoyo Sakata-Kato, Rebecca E K Mandt, Francisco-Javier Gamo, Dyann F Wirth, Amanda K Lukens
Drug resistance has been reported for every antimalarial in use highlighting the need for new strategies to protect the efficacy of therapeutics in development. We have previously shown that resistance can be suppressed with a population biology trap: by identifying situations where resistance to one compound confers hypersensitivity to another (collateral sensitivity), we can design combination therapies that not only kill the parasite, but also guide its evolution away from resistance. We applied this concept to the Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) enzyme, a well validated antimalarial target with inhibitors in the development pipeline...
January 16, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29327216/dental-erosion-prevalence-and-risk-factors-among-a-group-of-adolescents-in-stockholm-county
#4
M Skalsky Jarkander, M Grindefjord, K Carlstedt
AIMS: To investigate the prevalence and risk factors of dental erosion (DE) among a group of adolescents in Stockholm County. MATERIALS AND METHODS: This cross sectional cohort study was conducted at three clinics of the Public Dental Service in Stockholm County. Fifteen and 17 year old adolescents (1335) who scheduled their regular dental health examination were asked to participate. After drop-outs a sample of 1071 individuals, 547 males and 524 females were enrolled in the study...
January 11, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29310700/a-cross-sectional-study-of-the-filarial-and-leishmania-co-endemicity-in-two-ecologically-distinct-settings-in-mali
#5
Moussa Brema Sangare, Yaya Ibrahim Coulibaly, Siaka Yamoussa Coulibaly, Michel Emmanuel Coulibaly, Bourama Traore, Ilo Dicko, Ibrahim Moussa Sissoko, Sibiry Samake, Sekou Fantamady Traore, Thomas Bruce Nutman, Jesus Gilberto Valenzuela, Ousmane Faye, Shaden Kamhawi, Fabiano Oliveira, Roshanak Tolouei Semnani, Seydou Doumbia
BACKGROUND: Filariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Mansonella perstans) and Leishmania major parasites in two ecologically distinct areas of Mali, the Kolokani district (villages of Tieneguebougou and Bougoudiana) in North Sudan Savanna area, and the district of Kolondieba (village of Boundioba) in the South Sudan Savanna area...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29303955/reward-dysfunction-in-the-manic-spectrum-unable-to-win-the-use-of-biographical-information-to-refine-neurobiological-modeling
#6
David A Kahn
OBJECTIVE: The manic spectrum is thought to be characterized by a hypersensitive biobehavioral reward system, the behavioral activation system. Evidence for this framework comes from questionnaire-based, self-report data collected in cross-sectional and prospective studies of mania, mania in remission, and proneness to hypomania, and from functional neuroimaging investigations of brain reward circuit activity during incentivized choice protocols. Although heightened reward anticipation is consistently documented, the status of later goal attainment activity, hedonic responses, and satiety reactions is less clear...
November 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29303954/reward-dysfunction-in-the-manic-spectrum-unable-to-win-the-use-of-biographical-information-to-refine-neurobiological-modeling
#7
John F Gottlieb
OBJECTIVE: The manic spectrum is thought to be characterized by a hypersensitive biobehavioral reward system, the behavioral activation system. Evidence for this framework comes from questionnaire-based, self-report data collected in cross-sectional and prospective studies of mania, mania in remission, and proneness to hypomania, and from functional neuroimaging investigations of brain reward circuit activity during incentivized choice protocols. Although heightened reward anticipation is consistently documented, the status of later goal attainment activity, hedonic responses, and satiety reactions is less clear...
November 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29285568/characterization-of-migraineurs-presenting-interictal-widespread-pressure-hyperalgesia-identified-using-a-tender-point-count-a-cross-sectional-study
#8
Toshihide Toriyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo
BACKGROUND: Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressure hyperalgesia determined by a tender point. This study was performed to examine whether: 1) there is a subgroup of episodic migraineurs with widespread pressure hyperalgesia during and between attacks; 2) if such a subgroup exists, what is the prevalence and what is the difference between groups with interictal widespread hyperalgesia and acute allodynia regarding the demographic and clinical characteristics of migraine...
December 28, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29249113/-delayed-allergic-reaction-to-amlodipine-with-a-positive-lymphocyte-transformation-test
#9
Olga Patricia Monge-Ortega, Javier Domínguez-Ortega, Miguel González-Muñoz, Rosario Cabañas, Magdalena Lluch-Bernal, Ana Fiandor, Luz Yadira Bravo-Gallego, Santiago Quirce
BACKGROUND: Amlodipine is one of the third generation dihydropyridine calcium channel blockers used for hypertension. Mild, moderate and severe reactions have been reported with calcium channel blockers. Cross-reactivity among these drugs has not been established. CLINICAL REPORT: We have presented the case of a patient who developed a delayed pruritic, and erythematous maculopapular skin exanthema after the intake of amlodipine. A positive lymphocyte transformation test (LTT) confirmed the implication of amlodipine in the reaction and showed positivity to another calcium channel blocker, nifedipine, demonstrating cross reactivity...
October 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29207607/cyclin-a2-regulates-homologous-recombination-dna-repair-and-sensitivity-to-dna-damaging-agents-and-poly-adp-ribose-polymerase-parp-inhibitors-in-human-breast-cancer-cells
#10
Wei Wei Gu, Jie Lin, Xing Yu Hong
Defects in homologous recombination (HR) repair are found in breast cancers. Intriguingly, breast cancers with defective HR show increased sensitivity to DNA crosslinking agents and poly(ADP-ribose) polymerase (PARP) inhibitors. As such, genes that can affect HR functions have been of high interest in studies aiming to develop biomarkers for predicting response to treatment with these agents. Cyclin A2 is a key component of the core cell cycle machinery. However, whether cyclin A2 dysfunctions could cause HR defect and mediate sensitivity to DNA damaging agents remain unclear...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29202250/systemic-granulomatous-disease-in-dairy-cattle-during-a-dicyandiamide-feeding-trial
#11
J Cayzer, K N Buckle, J S Munday, S F Ledgard, A Heiser, A Thatcher
CASE HISTORY: Mature, in-calf, non-lactating, Friesian or Friesian-cross cows were fed dicyandiamide (DCD) at daily doses of 0.15 g/kg (Group 1; n=31), 0.45 g/kg (Group 2; n=21) and 0.75 g/kg (Group 3; n=12), as part of a safety trial, which also included a control group (n=15). Daily health observations were carried out on each cow until Day 86 of the study. On Day 28 one cow from Group 3 was observed with signs of disease, and subsequently in other cows. CLINICAL FINDINGS: Clinical signs in the first case included depression, pyrexia (40...
December 4, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29198933/dimensionality-and-reliability-of-the-central-sensitization-inventory-csi-in-a-pooled-multi-country-sample
#12
Antonio I Cuesta-Vargas, Randy Neblett, Alessandro Chiarotto, Jeroen Kregel, Jo Nijs, C P van Wilgen, Laurent Pitance, Aleksandar Knezevic, Robert J Gatchel, Tom G Mayer, Carlotta Viti, Cristina Roldan-Jiménez, Marco Testa, Wolnei Caumo, Milica Jeremic-Knezevic, Juan V Luciano
Central Sensitization (CS) involves the amplification of neural signaling within the central nervous system, which evokes pain hypersensitivity. The Central Sensitization Inventory (CSI) assesses 25 overlapping health-related symptom dimensions that have been found to be associated with CS-related disorders. Previous studies have found satisfactory test-retest reliability and internal consistency, but factor analyses have exhibited conflicting results in different language versions. The purpose of this cross-sectional study was to thoroughly examine the dimensionality and reliability of the CSI, with pooled data from 1,987 individuals, collected in several countries...
November 30, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29187897/glycan-and-peptide-ige-epitopes-of-the-tnf-alpha-blockers-infliximab-and-adalimumab-precision-diagnostics-by-cross-reactivity-immune-profiling-of-patient-sera
#13
Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey, Thomas A Platts-Mills, Uta Jappe
Biological drugs like therapeutic antibodies are widely used for the treatment of various diseases like inflammatory disorders and cancer. A drawback of these novel treatments is the substantial proportion of patients experiencing adverse reactions such as loss-of-drug effect or hypersensitivity reactions. These reactions are associated with pre-existing and/or developing anti-drug antibodies. Especially IgE development is a risk factor for life-threatening systemic anaphylaxis. METHODS: In order to characterize the individual drug-specific serum IgE, an IgE cross-reactivity immune profiling (ICRIP) assay was developed...
2017: Theranostics
https://www.readbyqxmd.com/read/29182455/isolation-of-blood-brain-barrier-crossing-antibodies-from-a-phage-display-library-by-competitive-elution-and-their-ability-to-penetrate-the-central-nervous-system
#14
George Thom, Jon Hatcher, Arron Hearn, Judy Paterson, Natalia Rodrigo, Arthur Beljeana Ian Gurrell, Carl Webster
The blood-brain barrier (BBB) is a formidable obstacle for delivery of biologic therapeutics to central nervous system (CNS) targets. Whilst the BBB prevents passage of the vast majority of molecules, it also selectively transports a wide variety of molecules required to maintain brain homeostasis. Receptor-mediated transcytosis is one example of a macromolecule transport system that is employed by cells of the BBB to supply essential proteins to the brain and which can be utilized to deliver biologic payloads, such as antibodies, across the BBB...
November 28, 2017: MAbs
https://www.readbyqxmd.com/read/29161206/a-hypersensitivity-like-response-to-meloidogyne-graminicola-in-rice-oryza-sativa-l
#15
Ngan Thi Phan, Dirk De Waele, Mathias Lorieux, Lizhong Xiong, Stephane Bellafiore
Meloidogyne graminicola (M. graminicola) is a major plant-parasitic nematode affecting rice cultivation in Asia. Resistance to this nematode was found in the African rice genotypes Oryza glaberrima and O. longistaminata, however, due to interspecific hybrid sterility, the introgression of resistance genes in the widely consumed O. sativa varieties remains challenging. Recently, resistance was found in O. sativa and here we report for the first time the histological and genetic characterization of the resistance to M...
November 21, 2017: Phytopathology
https://www.readbyqxmd.com/read/29159565/a-comprehensive-review-on-mustard-induced-allergy-and-implications-for-human-health
#16
REVIEW
Akanksha Sharma, Alok K Verma, Rinkesh Kumar Gupta, Neelabh, Premendra D Dwivedi
Mustard is widely used in a variety of foods/food products to enhance the flavor and nutritional value that subsequently raise the risk of hypersensitivity reactions. Mustard allergy has been reported for many years and is increasing gradually especially in the areas where its consumption is comparatively higher, and it may be considered among the most important food allergies. A number of relevant clinical studies focused on mustard-induced allergic manifestations are summarized in the current review. In addition, the knowledge regarding the immunological as well as biochemical characteristics of mustard allergens that have been known till date and their cross-reactivity with other food allergens have also been discussed here...
November 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29156361/non-suicidal-self-injury-in-referred-adolescents-with-mood-disorders-and-its-association-with-cyclothymic-hypersensitive-temperament
#17
Gabriele Masi, Annarita Milone, Anna Rita Montesanto, Elena Valente, Simone Pisano
BACKGROUND: Non suicidal self-injuries (NSSIs) are deliberate self-harm behaviors without suicidal intent, usually starting in adolescence, with increasing rates of occurrence both in epidemiological and clinical samples. Several studies associated cyclothymic-hypersensitive temperament (CHT) with self-harm behaviors and suicidal risk. Aim of this study is to explore the association between NSSIs and CHT in a clinical sample of adolescents. We hypothesized that CHT may differentiate NSSI from non-NSSI adolescents with mood disorders, when other psychopathological features are controlled for...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154021/diagnosis-of-fanconi-anaemia-by-ionising-radiation-or-mitomycin-c-induced-micronuclei
#18
Flavia Zita Francies, Rosalind Wainwright, Janet Poole, Kim De Leeneer, Ilse Coene, Greet Wieme, Hélène A Poirel, Bénédicte Brichard, Stephanie Vermeulen, Anne Vral, Jacobus Slabbert, Kathleen Claes, Ans Baeyens
Fanconi Anaemia (FA) is an autosomal recessive disorder characterised by defects in DNA repair, associated with chromosomal instability and cellular hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC). The FA repair pathway involves complex DNA repair mechanisms crucial for genomic stability. Deficiencies in DNA repair genes give rise to chromosomal radiosensitivity. FA patients have shown increased clinical radiosensitivity by exhibiting adverse normal tissue side-effects. The study aimed to investigate chromosomal radiosensitivity of homozygous and heterozygous carriers of FA mutations using three micronucleus (MN) assays...
November 8, 2017: DNA Repair
https://www.readbyqxmd.com/read/29134656/long-term-dynamic-synaptic-reorganization-after-gabaergic-precursor-cell-transplantation-into-adult-mouse-spinal-cord
#19
Ida J Llewellyn-Smith, Allan I Basbaum, João M Bráz
Transplanting embryonic precursors of GABAergic neurons from the medial ganglionic eminence (MGE) into adult mouse spinal cord ameliorates mechanical and thermal hypersensitivity in peripheral nerve injury models of neuropathic pain. Although Fos and transneuronal tracing studies strongly suggest that integration of MGE-derived neurons into host spinal cord circuits underlies recovery of function, the extent to which there is synaptic integration of the transplanted cells has not been established. Here, we used electron microscopic immunocytochemistry to assess directly integration of GFP-expressing MGE-derived neuronal precursors into dorsal horn circuitry in intact, adult mice with short- (5-6 weeks) or long-term (4-6 months) transplants...
November 13, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29101366/identification-of-an-analgesic-lipopeptide-produced-by-the-probiotic-escherichia-coli-strain-nissle-1917
#20
Teresa Pérez-Berezo, Julien Pujo, Patricia Martin, Pauline Le Faouder, Jean-Marie Galano, Alexandre Guy, Claude Knauf, Jean Claude Tabet, Sophie Tronnet, Frederick Barreau, Maud Heuillet, Gilles Dietrich, Justine Bertrand-Michel, Thierry Durand, Eric Oswald, Nicolas Cenac
Administration of the probiotic Escherichia coli strain Nissle 1917 (EcN) decreases visceral pain associated with irritable bowel syndrome. Mutation of clbA, a gene involved in the biosynthesis of secondary metabolites, including colibactin, was previously shown to abrogate EcN probiotic activity. Here, we show that EcN, but not an isogenic clbA mutant, produces an analgesic lipopeptide. We characterize lipoamino acids and lipopeptides produced by EcN but not by the mutant by online liquid chromatography mass spectrometry...
November 3, 2017: Nature Communications
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