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Crossed hypersensitivity

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https://www.readbyqxmd.com/read/28096358/repair-shielding-of-platinum-dna-lesions-in-testicular-germ-cell-tumors-by-high-mobility-group-box-protein-4-imparts-cisplatin-hypersensitivity
#1
Samuel G Awuah, Imogen A Riddell, Stephen J Lippard
Cisplatin is the most commonly used anticancer drug for the treatment of testicular germ cell tumors (TGCTs). The hypersensitivity of TGCTs to cisplatin is a subject of widespread interest. Here, we show that high-mobility group box protein 4 (HMGB4), a protein preferentially expressed in testes, uniquely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastrand cross-links, to potentiate the sensitivity of TGCTs to cisplatin therapy. We used CRISPR/Cas9-mediated gene editing to knockout the HMGB4 gene in a testicular human embryonic carcinoma and examined cellular responses...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28081290/membrane-microdomains-and-the-cytoskeleton-constrain-athir1-dynamics-and-facilitate-the-formation-of-an-athir1-associated-immune-complex
#2
Xueqin Lv, Yanping Jing, Jianwei Xiao, Yongdeng Zhang, Yingfang Zhu, Russell Julian, Jinxing Lin
Arabidopsis hypersensitive induced reaction (AtHIR) proteins function in plant innate immunity. However, the underlying mechanisms by which AtHIRs participate in plant immunity remain elusive. Here, using VA-TIRFM and FLIM-FRET, we revealed that AtHIR1 is present in membrane microdomains and co-localizes with the membrane microdomain marker REM1.3. Single-particle tracking analysis revealed that membrane microdomains and the cytoskeleton, especially microtubules, restrict the lateral mobility of AtHIR1 at the plasma membrane and facilitate its oligomerization...
January 12, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28074390/anti-allergic-triterpenes-isolated-from-olive-milled-waste
#3
Asuka Kishikawa, Yhiya Amen, Kuniyoshi Shimizu
The degranulation of basophils stimulated by antigen is one of the allergic mechanisms of immediate hypersensitivity reactions. In a previous study, the β-hexosaminidase release of rat basophilic leukemia (RBL-2H3) cells stimulated by IgE cross-linking was specifically inhibited by ethanol extract of olive milled waste (OMW). OMW is a potential source of triterpenes, which show several biological activities. However, little is known about the effect of triterpenes in OMW on β-hexosaminidase release. Here we investigated anti-allergic triterpenes from the ethanol extract of OMW, and we discuss the structure-activity relationship...
January 10, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28059686/the-role-of-spinal-thrombin-through-protease-activated-receptor-1-in-hyperalgesia-after-neural-injury
#4
Jenell R Smith, Beth A Winkelstein
OBJECTIVE Painful neuropathic injuries induce blood-spinal cord barrier (BSCB) breakdown, allowing pro-inflammatory serum molecules to cross the BSCB, which contributes to nociception. The goal of these studies was to determine whether the blood-borne serine protease thrombin also crosses a permeable BSCB, contributing to nociception through its activation of protease-activated receptor-1 (PAR1). METHODS A 15-minute C-7 nerve root compression, which induces BSCB breakdown and painful behaviors by Day 1, was administered in the rat (n = 10); sham operation (n = 11) and a 3-minute compression (n = 10) that does not induce sensitivity were administered as controls...
January 6, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28049195/immediate-type-hypersensitivity-to-heparins-two-case-reports-and-a-review-of-the-literature
#5
Philipp Cesana, Kathrin Scherer, Andreas J Bircher
Immediate type hypersensitivity reactions due to heparins are rare, and the exact immunologic pathomechanism has not been identified so far. In our 2 case reports, we describe first a 50-year-old female who received dalteparin (Fragmin®) and developed signs of an immediate type hypersensitivity reaction. The personal history revealed a previous application of dalteparin (Fragmin®). Evaluation with a skin prick test showed positive results for dalteparin. The second case deals with a 73-year-old female with a suspected immediate type reaction after the administration of dalteparin (Fragmin®)...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28032637/nitrogen-limitation-adaptation-nla-is-involved-in-source-to-sink-remobilization-of-nitrate-by-mediating-the-degradation-of-nrt1-7-in-arabidopsis
#6
Wenwen Liu, Qing Sun, Kai Wang, Qingguo Du, Wen-Xue Li
Recent studies on nitrate transporters (NRTs) have greatly increased our knowledge of the mechanisms regulating nitrogen (N) homeostasis in plants. However, an understanding of how these NRTs are regulated is still lacking. The nitrogen limitation adaptation (nla) mutant is hypersensitive to N limitation. In the nla mutant, (15) N-nitrate spotted on old leaves preferentially accumulated in the youngest leaves. Analysis of leaf cross-sections indicated that NLA expression was expressed in the sieve element and companion cell system...
December 29, 2016: New Phytologist
https://www.readbyqxmd.com/read/28004308/cutaneous-side-effects-and-transepidermal-water-loss-to-gefitinib-a-study-of-11-patients
#7
Franky Chandra, Dendi Sandiono, Unwati Sugiri, Oki Suwarsa, Hendra Gunawan
INTRODUCTION: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor. METHODS: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016...
December 21, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/28002236/patch-test-reactions-to-corticosteroids-retrospective-analysis-from-the-north-american-contact-dermatitis-group-2007-2014
#8
Melanie D Pratt, Asfandyar Mufti, Jennifer Lipson, Erin M Warshaw, Howard I Maibach, James S Taylor, Denis Sasseville, Joel G DeKoven, Matthew J Zirwas, Anthony F Fransway, C G Toby Mathias, Kathryn A Zug, Vincent A DeLeo, Joseph F Fowler, James G Marks, Frances J Storrs, Donald V Belsito
INTRODUCTION: Corticosteroids may cause delayed hypersensitivity. On the basis of structure, the following 4 groups of corticosteroids are recognized: A, B, C, and D (subdivided into D1 and D2). More recently, a newer classification system subdivides corticosteroids into groups 1, 2, and 3. Cross-reactions are unpredictable. The objective of this study was to describe positive patch test and co-reaction patterns to corticosteroids. METHODS AND RESULTS: A retrospective analysis of 17,978 patients patch tested by the North American Contact Dermatitis Group between 2007 and 2014 was performed...
January 2017: Dermatitis
https://www.readbyqxmd.com/read/27997083/acute-sacral-nerve-stimulation-reduces-visceral-mechanosensitivity-in-a-cross-organ-sensitization-model
#9
L D Langlois, E Le Long, M Meleine, M Antor, K Atmani, P Dechelotte, A M Leroi, G Gourcerol
BACKGROUND: Sacral nerve stimulation (SNS) is a surgical treatment of fecal and urinary incontinence that consists of inserting a stimulating electrode into one of the s3 or s4 sacral holes. In addition to the benefit of SNS in the treatment of incontinence, recent studies showed that SNS is effective in the treatment of irritable bowel syndrome as well as bladder pain syndrome. The aim of this study was to evaluate the effect of SNS on visceral mechanosensitivity in a cross-organ sensitization rat model...
November 7, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27996942/ige-reactivity-to-polcalcins-varies-according-to-pollen-source
#10
R Asero, G Mistrello, S Amato
BACKGROUND: Polcalcins are highly cross-reactive pollen panallergens. Less than 10% of allergic patients are sensitized to polcalcins. All pollen species are considered able to sensitize patients to this panallergen. OBJECTIVE: We aimed to assess the presence of polcalcins in various pollen extracts used in allergen immunotherapy. METHODS: ELISA inhibition experiments were performed with sera from patients sensitized to polcalcin and rPhl p 7 and rBet v 4...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27992990/papular-urticaria-a-review-of-causal-agents-in-colombia
#11
Ana Milena Lozano, Juan Felipe López, Josefina Zakzuk, Elizabeth García
Papular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. The objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in Latin American countries.We conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms.Several reports from medical centers suggest that papular urticaria is common in Latin America...
December 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27992542/self-reported-food-hypersensitivity-prevalence-characteristics-and-comorbidities-in-the-norwegian-women-and-cancer-study
#12
Monika Dybdahl Jakobsen, Tonje Braaten, Aud Obstfelder, Birgit Abelsen
BACKGROUND: This study aims to investigate the prevalence of self-reported food hypersensitivity, (SFH), the characteristics of women with SFH, and whether SFH is associated with multiple health complaints among the participants of the Norwegian Women and Cancer study (NOWAC). METHODS: We conducted a cross-sectional study among 64,316 women aged 41-76 years. The women were randomly selected from the Norwegian Central Person Register. Information on SFH and all covariates except age and place of residence was collected by questionnaires in 2002-2005...
2016: PloS One
https://www.readbyqxmd.com/read/27986566/a-flavanone-derivative-from-the-asian-medicinal-herb-perilla-frutescens-potently-suppresses-ige-mediated-immediate-hypersensitivity-reactions
#13
Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto
Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P...
December 13, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27979022/association-of-severity-of-chronic-rhinosinusitis-with-degree-of-comorbid-asthma-control
#14
Katie M Phillips, Lloyd P Hoehle, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
BACKGROUND: Comorbid chronic rhinosinusitis (CRS) is associated with worse asthma control. However, no study has investigated whether CRS severity affects the degree of asthma control. OBJECTIVE: To determine the effect size of an association between CRS severity and asthma control. METHODS: A pilot study with a prospective cross-sectional design. Adult patients with CRS and asthma were recruited. CRS severity was measured using the 22-item Sinonasal Outcomes Test (SNOT-22), and asthma control was measured using the Asthma Control Test (ACT)...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27966656/neonatal-repetitive-pain-in-rats-leads-to-impaired-spatial-learning-and-dysregulated-hypothalamic-pituitary-adrenal-axis-function-in-later-life
#15
Mengying Chen, Dongqing Xia, Cuiting Min, Xiaoke Zhao, Yinhua Chen, Li Liu, Xiaonan Li
Preterm birth is a major health issue. As part of their life-saving care, most preterm infants require hospitalization and are inevitably exposed to repetitive skin-breaking procedures. The long-term effects of neonatal repetitive pain on cognitive and emotional behaviors involving hypothalamic-pituitary-adrenal (HPA) axis function in young and adult rats are unknown. From P8 to P85, mechanical hypersensitivity of the bilateral hindpaws was observed in the Needle group (P < 0.001). Compared with the Tactile group, the Needle group took longer to find the platform on P30 than on P29 (P = 0...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27960170/classification-of-drug-hypersensitivity-into-allergic-p-i-and-pseudo-allergic-forms
#16
Werner J Pichler, Oliver Hausmann
Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive factor in understanding and managing DHR. Three mechanisms can be delineated: (a) some drugs have or gain the ability to bind covalently to proteins, form new antigens, and thus elicit immune reactions to hapten-carrier complexes (allergic/immune reaction); (b) a substantial part of immune-mediated DHR is due to a typical off-target activity of drugs on immune receptors like HLA and TCR (pharmacological interaction with immune receptors, p-i reactions); such p-i reactions are linked to severe DHR; and (c) symptoms of DHR can also appear if the drug stimulates or inhibits receptors or enzymes of inflammatory cells (pseudo-allergy)...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27936971/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-incidence-pathogenesis-and-management
#17
Tetsuo Shiohara, Yoko Kano
Drug-induced hypersensitivity syndrome(DiHS), often referred to as drug reaction with eosinophilia and systemic symptoms (DRESS), is a life-threatening multi-organ system reaction induced by drugs and associated with sequential reactivations of herpesviruses. This syndrome has several unique features, creating uncertainty over whether it represents true drug eruption. Areas covered: A literature review of all the cases was made by a Pub Med search. The delayed onset, paradoxical worsening of clinical symptoms after withdrawal of the causative drug and unexplained cross-reactivity to multiple drugs are unique features of this syndrome, which could prompt infection to be an initial consideration...
December 21, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27934618/cross-reactivity-of-cephalosporins-allergic-immediate-hypersensitivity-to-ceftriaxone-in-a-cefcapene-pivoxil-sensitized-patient
#18
Tokiko Deguchi, Yutaka Shimomura, Ryota Hayashi, Mari Orime, Katsuhiro Tomiyama, Riichiro Abe
No abstract text is available yet for this article.
December 8, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27924166/dental-erosion-and-dentin-hypersensitivity-among-adult-asthmatics-and-non-asthmatics-hospital-based-a-preliminary-study
#19
Zahra Hassan Abdelaziz Farag, Elhadi Mohieldin Awooda
BACKGROUND: Asthma is a chronic inflammatory condition affecting the airways leading to spasm and swelling of the airways. The medications taken for the treatment of asthma can result in dental erosion and dentin hypersensitivity. OBJECTIVES: The aims of this study were to investigate the severity of dental erosion amongst adult asthmatics according to: gender, type and duration of medication taken and to compare dental erosion and dentin hypersensitivity between asthmatics and non-asthmatics...
2016: Open Dentistry Journal
https://www.readbyqxmd.com/read/27919024/trigger-points-are-associated-with-widespread-pressure-pain-sensitivity-in-people-with-tension-type-headache
#20
María Palacios-Ceña, Kelun Wang, Matteo Castaldo, Amparo Guillem-Mesado, Carlos Ordás-Bandera, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate the association between trigger points (TrPs) and widespread pressure pain sensitivity in people with tension-type headache (TTH) and to determine if this association is different between frequent episodic (FETTH) or chronic (CTTH) headache. DESIGN: A cross-sectional study. METHODS: One hundred and fifty-seven individuals (29% male) with TTH participated. Clinical features of headache, i.e., intensity, duration, and frequency, were recorded in a headache diary...
November 14, 2016: Cephalalgia: An International Journal of Headache
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