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Nsaids hypersensibility

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https://www.readbyqxmd.com/read/19585860/multiple-drug-hypersensivity-insight-into-the-underlying-mechanism-and-correlation-with-autoimmune-diseases
#1
G Colombo, M R Yacoub, S E Burastero, E Garattini, S Girlanda, N Saporiti, F Salvo, M G Sabbadini
BACKGROUND: Subjects with drug hypersensitivity are sometimes simultaneously reactive to several drugs. This nosological entity is defined as multiple drug hypersensivity (MDH). Urticaria and angioedema are the commonest clinical manifestations of hypersensitivity drug reactions (HDR). These clinical signs are also pathognomonic of chronic idiopathic urticaria (CIU), whose pathogenetic mechanisms are still largely unknown. The diagnostic algorithm of CIU includes autologous serum skin test (ASST) and autologous plasma skin test (APST), which demonstrated a high positive and negative predictive value, in multiple nonsteroidal anti-inflammatory drugs (NSAIDs) intolerance...
April 2009: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/12705061/-pharmacology-of-cyclooxygenase-2-inhibition
#2
COMPARATIVE STUDY
Eckhard Beubler
Prostaglandins are important modulators of pain and inflammation. Both, pain and inflammation can be inhibited either at the level of the phospholipase A2 by corticosteroids or at the level of the cyclooxygenase (COX) by non steroidal anti-inflammatory drugs (NSAIDs). Formally, "cyclooxygenase" in general was thought to be responsible for the synthesis of prostaglandins involved in pain, inflammation and fever as well as cytoprotection in the stomach, hemostasis and blood flow in the kidneys. Later, two isoenzymes, cyclooxygenase-1 and cyclooxygenase-2 were discovered...
2003: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/10925522/-therapeutics-for-future-treatment-of-uveitis
#3
J Deschênes
The increased knowledge in immunology and the progresses of pharmacology have improved our treatment of autoimmune diseases. The main anti-inflammatory effects of corticosteroids are an attenuation of the hypersensibility reactions, a sequestration of intravascular lymphocytes and an inhibition of the production of cytokines and eicosanoids. The non-steroidal anti-inflammatory drugs (NSAID's) form another group of medications particularly useful for the treatment of chronic uveitis. Several Cox-2 inhibitory medications are at the moment under clinical investigation and some are commercially available...
2000: Bulletin de la Société Belge D'ophtalmologie
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