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https://www.readbyqxmd.com/read/28101605/surviving-sepsis-campaign-international-guidelines-for-management-of-sepsis-and-septic-shock-2016
#1
Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger
OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015...
January 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28098591/surviving-sepsis-campaign-international-guidelines-for-management-of-sepsis-and-septic-shock-2016
#2
Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger
OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012." DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015...
January 17, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28090077/clinical-and-biological-insights-from-viral-genome-sequencing
#3
Charlotte J Houldcroft, Mathew A Beale, Judith Breuer
Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not only for basic research but also for clinical science and practice. In virology, WGS is important for the development of novel treatments and vaccines, and for increasing the power of molecular epidemiology and evolutionary genomics. In this Opinion article, we suggest that WGS of viruses in a clinical setting will become increasingly important for patient care. We give an overview of different WGS methods that are used in virology and summarize their advantages and disadvantages...
January 16, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28087883/defining-genetic-and-chemical-diversity-in-wheat-grain-by-1h-nmr-spectroscopy-of-polar-metabolites
#4
Peter R Shewry, Delia I Corol, Huw D Jones, Michael H Beale, Jane L Ward
SCOPE: The application of high throughput 1H-NMR of unpurified extracts to determine to determine genetic diversity and the contents of polar components in grain of wheat. METHODS AND RESULTS: milled whole wheat grain was extracted with 80:20 D2O:CD3OD containing 0.05% d4- trimethylsilylpropionate (TSP). 1H-NMR spectra were acquired under automation at 300 °K using an Avance Spectrometer operating at 600.0528 MHz. Regions for individual metabolites were identified by comparison to a library of known standards run under identical conditions...
January 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28073100/investigating-the-use-of-appropriation-in-the-writing-of-a-child-with-autism-a-case-study
#5
Jamie Maxwell, Christine Weill, Jack Damico
This case study investigated how a 10year old child with ASD (Autism Spectrum Disorder), Kameron (pseudonym), utilized appropriation as a writing strategy in the context of group therapy. Using the same questions as Lensmire and Beals (1994) in their study of a typically developing third-grader, written products were collected over the course of one semester and analyzed, along with video, audio, and participant observation data, to consider the following questions: 1) Where did the material come from? 2) What was taken? and 3) How was it used? Analysis of the process of Kameron's writing revealed utilization of appropriation as a strategy for 2 of the 4 written products...
December 24, 2016: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28065170/multistate-outbreak-of-listeria-monocytogenes-infections-linked-to-whole-apples-used-in-commercially-produced-prepackaged-caramel-apples-united-states-2014-2015
#6
K M Angelo, A R Conrad, A Saupe, H Dragoo, N West, A Sorenson, A Barnes, M Doyle, J Beal, K A Jackson, S Stroika, C Tarr, Z Kucerova, S Lance, L H Gould, M Wise, B R Jackson
Whole apples have not been previously implicated in outbreaks of foodborne bacterial illness. We investigated a nationwide listeriosis outbreak associated with caramel apples. We defined an outbreak-associated case as an infection with one or both of two outbreak strains of Listeria monocytogenes highly related by whole-genome multilocus sequence typing (wgMLST) from 1 October 2014 to 1 February 2015. Single-interviewer open-ended interviews identified the source. Outbreak-associated cases were compared with non-outbreak-associated cases and traceback and environmental investigations were performed...
January 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28055970/genomic-analysis-of-exceptional-responders-to-radiotherapy-reveals-somatic-mutations-in-atm
#7
Jennifer Ma, Jeremy Setton, Luc Morris, Pedro Blecua Carrillo Albornoz, Christopher Barker, Benjamin H Lok, Eric Sherman, Nora Katabi, Kathryn Beal, Ian Ganly, Simon N Powell, Nancy Lee, Timothy A Chan, Nadeem Riaz
Radiation therapy is a mainstay of cancer treatment, yet the molecular determinants of clinical response are poorly understood. We identified exceptional responders to radiotherapy based on clinical response, and investigated the associated tumor sequencing data in order to identify additional patients with similar mutations. Among head and neck squamous cell cancer patients receiving palliative radiotherapy at our institution, we identified one patient with documented complete metabolic response. Targeted sequencing analysis of the tumor identified a somatic frame-shift mutation in ATM, a gene known to be associated with radio-sensitivity in the germline...
December 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/28048514/su-f-t-613-multi-lesion-cranial-srs-vmat-plan-quality
#8
A Ballangrud, L Kuo, L Happersett, S Lim, X Li, K Beal, Y Yamada, T LoSasso, J Mechalakos
PURPOSE: Cranial SRS VMAT plans must have steep dose gradient around each target to reduce dose to normal brain. This study reports on the correlation between gradient index (GI=V50%/V100%), target size and target dose heterogeneity index (HI=PTV Dmax/prescription dose) for multi-lesion cranial SRS VMAT plans. METHODS: VMAT plans for 10 cranial cases with 3 to 6 lesions (total 39 lesions) generated in Varian Eclipse V11.0.47 with a fine-tuned AAA beam model and 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040732/mutant-profilin1-transgenic-mice-recapitulate-cardinal-features-of-motor-neuron-disease
#9
Daniel Fil, Abigail DeLoach, Shilpi Yadav, Duah Alkam, Melanie MacNicol, Awantika Singh, Cesar M Compadre, Joseph J Goellner, Charles A O'Brien, Tariq Fahmi, Alexei G Basnakian, Noel Y Calingasan, Jodi L Klessner, M Flint Beal, Owen M Peters, Jake Metterville, Robert H Brown, Karen K Y Ling, Frank Rigo, P Hande Ozdinler, Mahmoud Kiaei
The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological role of mutant profilin1 in motor neuron disease, we generated transgenic lines of mice expressing human profilin1 with a mutation at position 118 (hPFN1(G118V)). One of the mouse lines expressing high levels of mutant human PFN1 protein in the brain and spinal cord exhibited many key clinical and pathological features consistent with human ALS disease...
December 30, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28033026/reliability-of-oronasal-fistula-classification
#10
Thomas J Sitzman, Alexander C Allori, Damir B Matic, Stephen P Beals, David M Fisher, Thomas D Samson, Jeffrey R Marcus, Raymond Tse, The Americleft Task Force Surgeon Subgroup
OBJECTIVE:   Oronasal fistula is an important complication of cleft palate repair that is frequently used to evaluate surgical quality, yet reliability of fistula classification has never been examined. The objective of this study was to determine the reliability of oronasal fistula classification both within individual surgeons and between multiple surgeons. DESIGN:   Using intraoral photographs of children with repaired cleft palate, surgeons rated the location of palatal fistulae using the Pittsburgh Fistula Classification System...
December 29, 2016: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28025547/a-review-of-analytical-techniques-and-their-application-in-disease-diagnosis-in-breathomics-and-salivaomics-research
#11
REVIEW
David J Beale, Oliver A H Jones, Avinash V Karpe, Saravanan Dayalan, Ding Yuan Oh, Konstantinos A Kouremenos, Warish Ahmed, Enzo A Palombo
The application of metabolomics to biological samples has been a key focus in systems biology research, which is aimed at the development of rapid diagnostic methods and the creation of personalized medicine. More recently, there has been a strong focus towards this approach applied to non-invasively acquired samples, such as saliva and exhaled breath. The analysis of these biological samples, in conjunction with other sample types and traditional diagnostic tests, has resulted in faster and more reliable characterization of a range of health disorders and diseases...
December 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28009564/automatic-processing-of-multimodal-tomography-datasets
#12
Aaron D Parsons, Stephen W T Price, Nicola Wadeson, Mark Basham, Andrew M Beale, Alun W Ashton, J Frederick W Mosselmans, Paul D Quinn
With the development of fourth-generation high-brightness synchrotrons on the horizon, the already large volume of data that will be collected on imaging and mapping beamlines is set to increase by orders of magnitude. As such, an easy and accessible way of dealing with such large datasets as quickly as possible is required in order to be able to address the core scientific problems during the experimental data collection. Savu is an accessible and flexible big data processing framework that is able to deal with both the variety and the volume of data of multimodal and multidimensional scientific datasets output such as those from chemical tomography experiments on the I18 microfocus scanning beamline at Diamond Light Source...
January 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28005532/designing-a-text-messaging-intervention-to-improve-physical-activity-behavior-among-low-income-latino-patients-with-diabetes-a-discrete-choice-experiment-los-angeles-2014-2015
#13
Magaly Ramirez, Shinyi Wu, Elizabeth Beale
INTRODUCTION: Automated text messaging can deliver self-management education to activate self-care behaviors among people with diabetes. We demonstrated how a discrete-choice experiment was used to determine the features of a text-messaging intervention that are important to urban, low-income Latino patients with diabetes and that could support improvement in their physical activity behavior. METHODS: In a discrete-choice experiment from December 2014 through August 2015 we conducted a survey to elicit information on patient preferences for 5 features of a text-messaging intervention...
December 22, 2016: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28001098/pre-eclampsia-and-risk-of-subsequent-hypertension-in-an-american-indian-population
#14
Lyle G Best, Laramie Lunday, Elisha Webster, Gilbert R Falcon, James R Beal
BACKGROUND AND OBJECTIVES: Pre-eclampsia (PE) shares a number of proposed pathophysiologic mechanisms related to those implicated in cardiovascular disease (CVD), such as endothelial dysfunction, inflammation, insulin resistance, and impaired renal regulation. PE has also been associated with subsequent hypertension, CVD, and related mortality in later life. METHODS: At follow-up, the four most recent blood pressures, body mass index (BMI), and use of hypertensive medications were recorded from clinic visits of 130 PE cases and 289 normal pregnancies...
December 21, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27992851/sepsis-as-2-problems-identifying-sepsis-at-admission-and-predicting-onset-in-the-hospital-using-an-electronic-medical-record-based-acuity-score
#15
Michael Rothman, Mitchell Levy, R Philip Dellinger, Stephen L Jones, Robert L Fogerty, Kirk G Voelker, Barry Gross, Albert Marchetti, Joseph Beals
PURPOSE: Early identification and treatment improve outcomes for patients with sepsis. Current screening tools are limited. We present a new approach, recognizing that sepsis patients comprise 2 distinct and unequal populations: patients with sepsis present on admission (85%) and patients who develop sepsis in the hospital (15%) with mortality rates of 12% and 35%, respectively. METHODS: Models are developed and tested based on 258 836 adult inpatient records from 4 hospitals...
December 3, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27986264/imaging-of-palatal-lumps
#16
REVIEW
C von Stempel, S Morley, T Beale, S Otero
Palatal tumours are relatively rare and of variable aetiology, rendering radiological evaluation a daunting process for many. A systematic approach to the imaging of a palatal lump is therefore essential. The hard and soft palates are oral cavity and oropharyngeal structures, respectively. They have different tissue compositions, and therefore, lesions occur with different frequencies at each site. The hard palate has the highest concentration of minor salivary glands in the upper aerodigestive tract and most tumours here are salivary in origin, whereas most tumours at the soft palate are epithelial in origin, i...
February 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27983674/current-and-future-perspectives-on-the-structural-identification-of-small-molecules-in-biological-systems
#17
REVIEW
Daniel A Dias, Oliver A H Jones, David J Beale, Berin A Boughton, Devin Benheim, Konstantinos A Kouremenos, Jean-Luc Wolfender, David S Wishart
Although significant advances have been made in recent years, the structural elucidation of small molecules continues to remain a challenging issue for metabolite profiling. Many metabolomic studies feature unknown compounds; sometimes even in the list of features identified as "statistically significant" in the study. Such metabolic "dark matter" means that much of the potential information collected by metabolomics studies is lost. Accurate structure elucidation allows researchers to identify these compounds...
December 15, 2016: Metabolites
https://www.readbyqxmd.com/read/27972276/cost-of-ebola-virus-disease-diagnosis-using-rapid-point-of-care-diagnostics-in-sierra-leone
#18
J S Evans, N C Hearmon, R C Beale, W Marsh
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972004/pharmacological-interventions-for-familial-hypercholesterolaemia-in-children-and-adolescents-a-systematic-literature-review
#19
R M Wickstead, J S Evans, B E Langford, R C Beale, W Marsh, J Kusel, M Griffiths
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971011/do-scottish-formulary-decisions-match-recommendations-made-by-the-smc
#20
R C Beale, J Kusel
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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