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https://www.readbyqxmd.com/read/29691125/perioperative-complications-and-the-cost-of-rescue-or-failure-to-rescue-in-hepato-pancreato-biliary-surgery
#1
Qinyu Chen, Eliza W Beal, Charles W Kimbrough, Fabio Bagante, Katiuscha Merath, Mary Dillhoff, Carl Schmidt, Susan White, Jordan Cloyd, Timothy M Pawlik
BACKGROUND: It is unclear how either the successful or failed rescue of hepato-pancreato-biliary (HPB) patients from complications impacts costs. METHODS: A retrospective cohort study of HPB surgical patients was performed using claims data from 2013 to 2015 in the Medicare Provider Analysis and Review (MEDPAR) database. Patient demographics, characteristics, outcomes and risk-adjusted Medicare payments were compared. RESULTS: 11,596 patients were identified...
April 21, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29687005/medium-long-term-radiographic-and-clinical-outcomes-after-surgical-treatment-of-intra-articular-tibial-pilon-fractures-by-three-different-techniques
#2
Carlo Biz, Andrea Angelini, Marco Zamperetti, Filippo Marzotto, Silvano Pierluigi Sperotto, Diego Carniel, Claudio Iacobellis, Pietro Ruggieri
Introduction: The goal of this retrospective, observational, case series study was to evaluate the medium-long-term clinical and radiographic results of the three most common surgical osteosynthesis techniques used for the treatment of articular tibial pilon fractures: ORIF, MIPO, and EF. Materials and Methods: A consecutive series of patients with articular pilon fractures who underwent surgery at our institution were enrolled in this study. Fractures were classified according to the Müller AO classification system...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29683790/multicenter-phase-ib-trial-of-carboxyamidotriazole-orotate-and-temozolomide-for-recurrent-and-newly-diagnosed-glioblastoma-and-other-anaplastic-gliomas
#3
Antonio Omuro, Kathryn Beal, Katharine McNeill, Robert J Young, Alissa Thomas, Xuling Lin, Robert Terziev, Thomas J Kaley, Lisa M DeAngelis, Mariza Daras, Igor T Gavrilovic, Ingo Mellinghoff, Eli L Diamond, Andrew McKeown, Malbora Manne, Andrew Caterfino, Krishna Patel, Linda Bavisotto, Greg Gorman, Michael Lamson, Philip Gutin, Viviane Tabar, Debyani Chakravarty, Timothy A Chan, Cameron W Brennan, Elizabeth Garrett-Mayer, Rashida A Karmali, Elena Pentsova
Purpose Carboxyamidotriazole orotate (CTO) is a novel oral inhibitor of non-voltage-dependent calcium channels with modulatory effects in multiple cell-signaling pathways and synergistic effects with temozolomide (TMZ) in glioblastoma (GBM) models. We conducted a phase IB study combining CTO with two standard TMZ schedules in GBM. Methods In cohort 1, patients with recurrent anaplastic gliomas or GBM received escalating doses of CTO (219 to 812.5 mg/m2 once daily or 600 mg fixed once-daily dose) combined with TMZ (150 mg/m2 5 days during each 28-day cycle)...
April 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29682609/prolonged-cannabidiol-treatment-effects-on-hippocampal-subfield-volumes-in-current-cannabis-users
#4
Camilla Beale, Samantha J Broyd, Yann Chye, Chao Suo, Mark Schira, Peter Galettis, Jennifer H Martin, Murat Yücel, Nadia Solowij
Introduction: Chronic cannabis use is associated with neuroanatomical alterations in the hippocampus. While adverse impacts of cannabis use are generally attributed to Δ9 -tetrahydrocannabinol, emerging naturalistic evidence suggests cannabidiol (CBD) is neuroprotective and may ameliorate brain harms associated with cannabis use, including protection from hippocampal volume loss. This study examined whether prolonged administration of CBD to regular cannabis users within the community could reverse or reduce the characteristic hippocampal harms associated with chronic cannabis use...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29682159/age-dependent-protective-effect-of-selenium-against-uva-irradiation-in-primary-human-keratinocytes-and-the-associated-dna-repair-signature
#5
C Favrot, D Beal, E Blouin, M T Leccia, A M Roussel, W Rachidi
Few studies have focused on the protective role of selenium (Se) against skin aging and photoaging even though selenoproteins are essential for keratinocyte function and skin development. To the best of our knowledge, the impact of Se supplementation on skin cells from elderly and young donors has not been reported. Therefore, the main objective of our study was to evaluate the effects of Se supplementation on skin keratinocytes at baseline and after exposure to ultraviolet A (UVA) irradiation. Low doses of Se (30 nM) were very potently protective against UVA-induced cytotoxicity in young keratinocytes, whereas the protection efficiency of Se in old keratinocytes required higher concentrations (240 nM)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29681529/variation-in-tibial-tuberosity-lateralization-and-distance-from-the-tibiofemoral-joint-line-an-anatomic-study
#6
John H Sojka, Joshua S Everhart, James C Kirven, Matthew D Beal, David C Flanigan
BACKGROUND: To describe variation in tibial tuberosity position in a normal adult population and inter-rater reliability of measurements of tibial tuberosity position. METHODS: Surface models of 161 proximal tibia specimens (83 female, 78 male; 80 black, 81 white; age 28.7years, SD 7.5) were created with a three-dimensional laser scanner. Percent lateralization, tuberosity-eminence angle, and distance from joint surface were measured for each specimen. Variation in tuberosity position by sex, race, age, height, and BMI was calculated...
April 19, 2018: Knee
https://www.readbyqxmd.com/read/29681247/food-choices-and-distress-in-reservation-based-american-indians-and-alaska-natives-with-type-2-diabetes
#7
Nicolette I Teufel-Shone, Luohua Jiang, Jennifer Rockell, Jennifer Chang, Janette Beals, Ann Bullock, Spero M Manson
OBJECTIVE: To examine the association between food choice and distress in a large national sample of American Indians/Alaska Natives (AI/AN) with type 2 diabetes. DESIGN: Participants completed a sociodemographic survey, an FFQ and the Kessler-6 Distress Scale. Foods were identified as 'healthy' or 'unhealthy' using a classification grounded in the health education provided by the programme case managers; healthy and unhealthy food scores were calculated using reported intake frequencies...
April 23, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29659823/a-hyperactivating-proinflammatory-ripk2-allele-associated-with-early-onset-osteoarthritis
#8
Michael J Jurynec, Allen D Sawitzke, Timothy C Beals, Michael J Redd, Jeff Stevens, Brith Otterud, Mark H Leppert, David Jonah Grunwald
Osteoarthritis (OA) is a common debilitating disease characterized by abnormal remodeling of the cartilage and bone of the articular joint. Ameliorating therapeutics are lacking due to limited understanding of the molecular pathways affecting disease initiation and progression. Notably, although a link between inflammation and overt OA is well established, the role of inflammation as a driver of disease occurrence is highly disputed. We analyzed a family with dominant inheritance of early-onset OA and found that affected individuals harbored a rare variant allele encoding a significant amino acid change (p...
April 12, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29657030/rewiring-of-glutamine-metabolism-is-a-bioenergetic-adaptation-of-human-cells-with-mitochondrial-dna-mutations
#9
Qiuying Chen, Kathryne Kirk, Yevgeniya I Shurubor, Dazhi Zhao, Andrea J Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L Calder, Valerio Carelli, Travis T Denton, M Flint Beal, Steven S Gross, Giovanni Manfredi, Marilena D'Aurelio
Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defects. Stimulating this flux with αKG supplementation enables the survival of diverse mtDNA mutant cells under otherwise lethal obligatory oxidative conditions. Strikingly, we demonstrate that when residual mitochondrial respiration in mtDNA mutant cells exceeds 45% of control levels, αKG oxidative flux prevails over reductive carboxylation...
April 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29656380/trends-in-use-of-lymphadenectomy-in-surgery-with-curative-intent-for-intrahepatic-cholangiocarcinoma
#10
X-F Zhang, J Chakedis, F Bagante, Q Chen, E W Beal, Y Lv, M Weiss, I Popescu, H P Marques, L Aldrighetti, S K Maithel, C Pulitano, T W Bauer, F Shen, G A Poultsides, O Soubrane, G Martel, B Groot Koerkamp, A Guglielmi, E Itaru, T M Pawlik
BACKGROUND: The role of routine lymph node dissection (LND) in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) remains controversial. The objective of this study was to investigate the trends of LND use in the surgical treatment of ICC. METHODS: Patients undergoing curative intent resection for ICC in 2000-2015 were identified from an international multi-institutional database. Use of lymphadenectomy was evaluated over time and by geographical region (West versus East); LND use and final nodal status were analysed relative to AJCC T categories...
April 14, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29623102/novel-signal-noise-reduction-method-through-cluster-analysis-applied-to-photoplethysmography
#11
William Waugh, John Allen, James Wightman, Andrew J Sims, Thomas A W Beale
Physiological signals can often become contaminated by noise from a variety of origins. In this paper, an algorithm is described for the reduction of sporadic noise from a continuous periodic signal. The design can be used where a sample of a periodic signal is required, for example, when an average pulse is needed for pulse wave analysis and characterization. The algorithm is based on cluster analysis for selecting similar repetitions or pulses from a periodic single. This method selects individual pulses without noise, returns a clean pulse signal, and terminates when a sufficiently clean and representative signal is received...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29622708/epidermoid-cyst-within-an-intrapancreatic-accessory-spleen
#12
Anghela Paredes, Eliza Wright Beal, Mary E Dillhoff
This is a case of an epidermoid cyst in an intrapancreatic accessory spleen at the tail of the pancreas. Concurrent epidermoid cyst within the accessory spleen is an exceedingly rare entity. The patient initially presented with abdominal pain, nausea and vomiting. Imaging studies revealed a 3.6 cm cystic mass in the tail of the pancreas that was concerning for a mucinous cystic neoplasm (MCN). The patient underwent a robotic distal pancreatectomy for a suspected diagnosis of MCN, which following histologically examination was found to be an epidermoid cyst of an intrapancreatic accessory spleen...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29621642/adipose-derived-stem-cells-improve-full-thickness-skin-grafts-in-a-rat-model
#13
Silvana Bellini Vidor, Paula Barros Terraciano, Fernanda Soldatelli Valente, Verônica Machado Rolim, Cristiana Palma Kuhl, Laura Silveira Ayres, Tuane Nerissa Alves Garcez, Natália Emerim Lemos, Cristiano Ely Kipper, Sabrina Beal Pizzato, David Driemeier, Elizabeth Obino Cirne-Lima, Emerson Antonio Contesini
To investigate the effects of heterologous adipose-derived stem cells (ADSCs) on autologous full-thickness skin grafts, we designed a first-intention healing model using Wistar rats. We harvested and sutured two full-thickness skin grafts in the dorsal recipient beds of 15 rats, randomized into three groups. In the treatment group, 1 × 106 ADSCs resuspended in saline solution (200 μL) were administered subcutaneously to the skin graft. The control group received only saline solution subcutaneously, whereas the negative control group did not receive any treatment...
March 28, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29620940/validation-and-generalizability-of-preoperative-promis-scores-to-predict-postoperative-success-in-foot-and-ankle-patients
#14
Michael R Anderson, Jeff R Houck, Charles L Saltzman, Man Hung, Florian Nickisch, Alexej Barg, Timothy Beals, Judith F Baumhauer
BACKGROUND: A recent publication reported preoperative Patient-Reported Outcomes Measurement Instrumentation System (PROMIS) scores to be highly predictive in identifying patients who would and would not benefit from foot and ankle surgery. Their applicability to other patient populations is unknown. The aim of this study was to assess the validation and generalizability of previously published preoperative PROMIS physical function (PF) and pain interference (PI) threshold t scores as predictors of postoperative clinically meaningful improvement in foot and ankle patients from a geographically unique patient population...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29614862/nanomaterial-interactions-with-biomembranes-bridging-the-gap-between-soft-matter-models-and-biological-context
#15
Marco Werner, Thorsten Auth, Paul A Beales, Jean Baptiste Fleury, Fredrik Höök, Holger Kress, Reid C Van Lehn, Marcus Müller, Eugene P Petrov, Lev Sarkisov, Jens-Uwe Sommer, Vladimir A Baulin
Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors' current understanding of the biological world...
April 3, 2018: Biointerphases
https://www.readbyqxmd.com/read/29614526/changes-in-scoring-of-direct-observation-of-procedural-skills-dops-forms-and-the-impact-on-competence-assessment
#16
Keith Siau, Paul Dunckley, Roland Valori, Mark Feeney, Neil D Hawkes, John T Anderson, Ian L P Beales, Christopher Wells, Siwan Thomas-Gibson, Gavin Johnson
BACKGROUND: Direct Observation of Procedural Skills (DOPS) is an established competence assessment tool in endoscopy. In July 2016, the DOPS scoring format changed from a performance-based scale to a supervision-based scale. We aimed to evaluate the impact of changes to the DOPS scale format on the distribution of scores in novice trainees and on competence assessment. METHODS: We performed a prospective, multicenter (n = 276), observational study of formative DOPS assessments in endoscopy trainees with ≤ 100 lifetime procedures...
April 3, 2018: Endoscopy
https://www.readbyqxmd.com/read/29607408/therapeutic-effects-of-prolonged-cannabidiol-treatment-on-psychological-symptoms-and-cognitive-function-in-regular-cannabis-users-a-pragmatic-open-label-clinical-trial
#17
Nadia Solowij, Samantha J Broyd, Camilla Beale, Julie-Anne Prick, Lisa-Marie Greenwood, Hendrika van Hell, Chao Suo, Peter Galettis, Nagesh Pai, Shanlin Fu, Rodney J Croft, Jennifer H Martin, Murat Yücel
Introduction: Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences. While Δ9 -tetrahydrocannabinol (THC) is thought to be primarily responsible for these deleterious effects, cannabidiol (CBD) is purported to have antipsychotic properties and to ameliorate cognitive, symptomatic, and brain harms in cannabis users. However, this has never been tested in a prolonged administration trial in otherwise healthy cannabis users...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29605823/synthetic-biology-open-language-sbol-version-2-2-0
#18
Robert Sidney Cox, Curtis Madsen, James Alastair McLaughlin, Tramy Nguyen, Nicholas Roehner, Bryan Bartley, Jacob Beal, Michael Bissell, Kiri Choi, Kevin Clancy, Raik Grünberg, Chris Macklin, Goksel Misirli, Ernst Oberortner, Matthew Pocock, Meher Samineni, Michael Zhang, Zhen Zhang, Zach Zundel, John H Gennari, Chris Myers, Herbert Sauro, Anil Wipat
Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems would be to improve the exchange of information about designed systems between laboratories. The synthetic biology open language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards...
April 2, 2018: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/29602747/the-predictive-ability-of-the-start-back-tool-was-limited-in-people-with-chronic-low-back-pain-a-prospective-cohort-study
#19
Michelle Kendell, Darren Beales, Peter O'Sullivan, Martin Rabey, Jonathan Hill, Anne Smith
QUESTIONS: In people with chronic non-specific low back pain (LBP), what is the predictive and discriminative validity of the STarT Back Tool (SBT) for pain intensity, self-reported LBP-related disability, and global self-perceived change at 1-year follow-up? What is the profile of the SBT risk subgroups with respect to demographic variables, pain intensity, self-reported LBP-related disability, and psychological measures? DESIGN: Prospective cohort study. PARTICIPANTS: A total of 290 adults with dominant axial LBP of≥3months' duration recruited from the general community, and private physiotherapy, psychology, and pain-management clinics in Western Australia...
March 27, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29600384/paclitaxel-as-albumin-bound-nanoparticles-with-gemcitabine-for-untreated-metastatic-pancreatic-cancer-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#20
REVIEW
Angela Stainthorpe, Janette Greenhalgh, Adrian Bagust, Marty Richardson, Angela Boland, Sophie Beale, Rui Duarte, Eleanor Kotas, Lindsay Banks, Daniel Palmer
As part of the single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited Celgene Ltd to submit clinical and cost-effectiveness evidence for paclitaxel as albumin-bound nanoparticles (Nab-Pac) in combination with gemcitabine (Nab-Pac + Gem) for patients with untreated metastatic pancreatic cancer. The STA was a review of NICE's 2015 guidance (TA360) in which Nab-Pac + Gem was not recommended for patients with untreated metastatic pancreatic cancer...
March 29, 2018: PharmacoEconomics
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