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https://www.readbyqxmd.com/read/28730354/early-recurrence-of-neuroendocrine-liver-metastasis-after-curative-hepatectomy-risk-factors-prognosis-and-treatment
#1
Xu-Feng Zhang, Eliza W Beal, Jeffery Chakedis, Yi Lv, Fabio Bagante, Luca Aldrighetti, George A Poultsides, Todd W Bauer, Ryan C Fields, Shishir Kumar Maithel, Hugo P Marques, Matthew Weiss, Timothy M Pawlik
BACKGROUND: Early tumor recurrence after curative resection typically indicates a poor prognosis. The objective of the current study was to investigate the risk factors, treatment, and prognosis of early recurrence of neuroendocrine tumor (NET) liver metastasis (NELM) after hepatic resection. METHODS: A total of 481 patients who underwent curative-intent resection for NELM were identified from a multi-institutional database. Data on clinicopathological characteristics, intraoperative details, and outcomes were documented...
July 20, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28729547/antarctic-sea-ice-region-as-a-source-of-biogenic-organic-nitrogen-in-aerosols
#2
Manuel Dall'Osto, Jurgita Ovadnevaite, Marco Paglione, David C S Beddows, Darius Ceburnis, Charlotte Cree, Pau Cortés, Marina Zamanillo, Sdena O Nunes, Gonzalo L Pérez, Eva Ortega-Retuerta, Mikhail Emelianov, Dolors Vaqué, Cèlia Marrasé, Marta Estrada, M Montserrat Sala, Montserrat Vidal, Mark F Fitzsimons, Rachael Beale, Ruth Airs, Matteo Rinaldi, Stefano Decesari, Maria Cristina Facchini, Roy M Harrison, Colin O'Dowd, Rafel Simó
Climate warming affects the development and distribution of sea ice, but at present the evidence of polar ecosystem feedbacks on climate through changes in the atmosphere is sparse. By means of synergistic atmospheric and oceanic measurements in the Southern Ocean near Antarctica, we present evidence that the microbiota of sea ice and sea ice-influenced ocean are a previously unknown significant source of atmospheric organic nitrogen, including low molecular weight alkyl-amines. Given the keystone role of nitrogen compounds in aerosol formation, growth and neutralization, our findings call for greater chemical and source diversity in the modelling efforts linking the marine ecosystem to aerosol-mediated climate effects in the Southern Ocean...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28725788/pathology-residents-comprise-inspection-team-for-a-cap-self-inspection
#3
Stacy G Beal, Jesse L Kresak, Anthony T Yachnis
We report our experience at the University of Florida in which residents and fellows served as the inspection team for a College of American Pathologists (CAP) self-inspection. We aimed to determine whether the CAP self-inspection could serve as a learning opportunity for pathology residents and fellows. To prepare for the inspection, we provided a series of 4 lunchtime seminars covering numerous laboratory management topics relating to inspections and laboratory quality. Preparation for the inspection began approximately 4 months prior to the date of the inspection...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28721890/the-prognostic-value-of-braf-c-kit-and-nras-mutations-in-melanoma-patients-with-brain-metastases
#4
Paul W Sperduto, Wen Jiang, Paul D Brown, Steve Braunstein, Penny Sneed, Daniel A Wattson, Helen A Shih, Ananta Bangdiwala, Ryan Shanley, Natalie A Lockney, Kathryn Beal, Emil Lou, Thomas Amatruda, William A Sperduto, John P Kirkpatrick, Norman Yeh, Laurie E Gaspar, Jason K Molitoris, Laura Masucci, David Roberge, James Yu, Veronica Chiang, Minesh Mehta
PURPOSE: Brain metastases are a common problem in patients with melanoma, but little is known about the effect of gene mutations on survival in these patients. METHODS AND MATERIALS: We created a retrospective multi-institutional database of 823 patients with melanoma and brain metastases diagnosed between 2006 and 2015. Clinical parameters, gene mutation status (BRAF, C-KIT, NRAS), and treatment were correlated with survival. Treatment patterns and outcomes were compared with a prior era (1985-2005)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28720787/comparison-between-an-african-town-and-a-neighbouring-village-shows-delayed-but-not-decreased-sleep-during-the-early-stages-of-urbanisation
#5
Andrew D Beale, Mario Pedrazzoli, Bruno da Silva B Gonçalves, Felipe Beijamini, Núbia E Duarte, Kieren J Egan, Kristen L Knutson, Malcolm von Schantz, Laura C Roden
The well-established negative health outcomes of sleep deprivation, and the suggestion that availability of electricity may enable later bed times without compensating sleep extension in the morning, have stimulated interest in studying communities whose sleep pattern may resemble a pre-industrial state. Here, we describe sleep and activity in two neighbouring communities, one urban (Milange) and one rural (Tengua), in a region of Mozambique where urbanisation is an ongoing process. The two communities differ in the amount and timing of daily activity and of light exposure, with later bedtimes (≈1 h) associated with more evening and less daytime light exposure seen in the town of Milange...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709460/semi-quantitative-influenza-a-population-averages-from-a-multiplex-respiratory-viral-panel-rvp-potential-for-reflecting-target-sequence-changes-affecting-the-assay
#6
Kenneth H Rand, Maura Pieretti, Rodney Arcenas, Stacy G Beal, Herbert Houck, Emma Boslet, John A Lednicky
BACKGROUND: Yearly influenza virus mutations potentially affect the performance of molecular assays, if nucleic acid changes involve the sequences in the assay. Because individual patient viral loads depend on variables such as duration of illness, specimen type, age, and immunosuppression, we examined seasonal population averages of positive tests to smooth inherent variability. METHODS: We studied the population seasonal averages of the semi-quantitative nAMPs for the influenza matrix and hemagglutinin genes in the GenMark (Carlsbad, CA) Respiratory Viral Panel assay between 3 institutions over 3 Influenza seasons...
July 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28709358/analytic-solutions-throughout-a-period-doubling-route-to-chaos
#7
Marko S Milosavljevic, Jonathan N Blakely, Aubrey N Beal, Ned J Corron
We show examples of dynamical systems that can be solved analytically at any point along a period doubling route to chaos. Each system consists of a linear part oscillating about a set point and a nonlinear rule for regularly updating that set point. Previously it has been shown that such systems can be solved analytically even when the oscillations are chaotic. However, these solvable systems show few bifurcations, transitioning directly from a steady state to chaos. Here we show that a simple change to the rule for updating the set point allows for a greater variety of nonlinear dynamical phenomena, such as period doubling, while maintaining solvability...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28704288/the-effectiveness-of-medical-simulation-in-teaching-medical-students-critical-care-medicine-a-systematic-review-and-meta-analysis
#8
Matthew David Beal, John Kinnear, Caroline Rachael Anderson, Thomas David Martin, Rachel Wamboldt, Lee Hooper
We aimed to assess effectiveness of simulation for teaching medical students critical care medicine and to assess which simulation methods were most useful. We searched AMED, EMBASE, MEDLINE, Education Resources Information Centre, British Education Index, Australian Education Index, and bibliographies and citations, in July 2013. Randomized controlled trials comparing effectiveness of simulation with another educational intervention, or no teaching, for teaching medical students critical care medicine were included...
April 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28695154/the-role-of-minority-stressors-in-lesbian-relationship-commitment-and-persistence-over-time
#9
Renzo J Barrantes, Asia A Eaton, Cindy B Veldhuis, Tonda L Hughes
The Investment Model of relationship commitment uses interpersonal investment, relationship satisfaction, quality of alternatives, and commitment to predict relationship longevity (Rusbult, 1980, 1983). Although ample support for the Investment Model has been found in heterosexual couples, it appears to be less powerful in predicting stability in same-sex relationships (Beals, Impett, & Peplau, 2002), potentially because the model does not account for factors unique to same-sex relationships, such as anti-gay discrimination...
June 2017: Psychology of Sexual Orientation and Gender Diversity
https://www.readbyqxmd.com/read/28693305/comparison-the-characteristics-of-canine-adipose-tissue-derived-mesenchymal-stem-cells-extracted-from-different-sites-and-at-different-passage-numbers
#10
Kevin M Yaneselli, Cristiana Palma Kuhl, Paula Barros Terraciano, Fernanda de Los Santos de Oliveira, Sabrina Beal Pizzato, Kamila Pazza, Alessandra Bileski Magrisso, Vanessa Torman, Analía Rial, María Moreno, Silvia Llambí, Elizabeth Cirne Lima, Jacqueline Maisonnave
Mesenchymal Stem Cells (MSCs) have attractive characteristics for therapy in animal models and veterinary medicine, due to the capacity of inducing tissue regeneration and immunomodulation. The objective of this study was to evaluate the differences between canine adipose tissue-derived MSCs (AD-MSCs) extracted from subcutaneous (Sc) and visceral (Vs) sites. Surface antigenic markers, in vitro differentiation and mineralized matrix quantification of AD-MSCs in different passages (P4, P6 and P8) were studied...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28691139/systematic-review-and-meta-analysis-use-of-statins-is-associated-with-a-reduced-incidence-of-oesophageal-adenocarcinoma
#11
Tom Thomas, Yoon Loke, Ian L P Beales
PURPOSE: Laboratory studies have suggested that statins may have useful anti-cancer effects against Barrett's epithelial cancer lines. A variety of effects have been reported in clinical studies. METHODS: We performed a systematic review and meta-analysis of the association between statin use and the development of oesophageal cancer. Multiple databases were searched for studies reporting the association of statin use and oesophageal cancer. Meta-analysis on the relationship between statin use and cancer incidence was performed...
July 10, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28685387/postoperative-abdominal-adhesions-clinical-significance-and-advances-in-prevention-and-management
#12
Demetrios Moris, Jeffery Chakedis, Amir A Rahnemai-Azar, Ana Wilson, Mairead Marion Hennessy, Antonios Athanasiou, Eliza W Beal, Chrysoula Argyrou, Evangelos Felekouras, Timothy M Pawlik
Postoperative adhesions remain one of the more challenging issues in surgical practice. Although peritoneal adhesions occur after every abdominal operation, the density, time interval to develop symptoms, and clinical presentation are highly variable with no predictable patterns. Numerous studies have investigated the pathophysiology of postoperative adhesions both in vitro and in vivo. Factors such as type and location of adhesions, as well as timing and recurrence of adhesive obstruction remain unpredictable and poorly understood...
July 6, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28682640/the-growth-of-peer-support-an-international-charter
#13
Anthony C Stratford, Matt Halpin, Keely Phillips, Frances Skerritt, Anne Beales, Vincent Cheng, Magdel Hammond, Mary O'Hagan, Catherine Loreto, Kim Tiengtom, Benon Kobe, Steve Harrington, Dan Fisher, Larry Davidson
OBJECTIVE: While mental health peer support originated in its contemporary form in English-speaking countries, it is now spreading rapidly across the globe. This rapid growth presents two major challenges. The first pertains to "role integrity" and the second to the possible culture-bound nature of peer support; a concern which has attended the emergence of peer support in countries that have significantly different worldviews. METHOD: Recognizing the growth of peer support and the resulting challenges, this report results from the convening of an international consortium of peer leaders from six continents (all but Antarctica)...
July 6, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28679543/tracing-genetic-exchange-and-biogeography-of-cryptococcus-neoformans-var-grubii-at-the-global-population-level
#14
Johanna Rhodes, Christopher A Desjardins, Sean M Sykes, Mathew A Beale, Mathieu Vanhove, Sharadha Sakthikumar, Yuan Chen, Sharvari Gujja, Sakina Saif, Anuradha Chowdhary, Daniel John Lawson, Vinicius Ponzio, Arnaldo Lopes Colombo, Wieland Meyer, David M Engelthaler, Ferry Hagen, Maria Teresa Illnait-Zaragozi, Alexandre Alanio, Jo-Marie Vreulink, Joseph Heitman, John R Perfect, Anastasia Litvintseva, Tihana Bicanic, Thomas S Harrison, Matthew C Fisher, Christina A Cuomo
Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals, typically HIV/AIDS patients from developing countries. Despite the worldwide emergence of this ubiquitous infection, little is known about the global molecular epidemiology of this fungal pathogen. Here we sequence the genomes of 188 diverse isolates and characterized the major subdivisions, their relative diversity and the level of genetic exchange between them...
July 5, 2017: Genetics
https://www.readbyqxmd.com/read/28671223/differential-proteomics-highlights-macrophage-specific-responses-to-amorphous-silica-nanoparticles
#15
Bastien Dalzon, Catherine Aude-Garcia, Véronique Collin-Faure, Hélène Diemer, David Béal, Fanny Dussert, Daphna Fenel, Guy Schoehn, Sarah Cianférani, Marie Carrière, Thierry Rabilloud
The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms. One of the highly produced nanomaterials under such scrutiny is amorphous silica nanoparticles, which are known to have an appreciable, although reversible, inflammatory potential. This is due to their selective toxicity toward macrophages, and it is thus important to study the cellular responses of this cell type to silica nanoparticles to better understand the direct or indirect adverse effects of nanosilica...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28671030/continuous-in-vitro-exposure-of-intestinal-epithelial-cells-to-e171-food-additive-causes-oxidative-stress-inducing-oxidation-of-dna-bases-but-no-endoplasmic-reticulum-stress
#16
Marie Dorier, David Béal, Caroline Marie-Desvergne, Muriel Dubosson, Frédérick Barreau, Eric Houdeau, Nathalie Herlin-Boime, Marie Carriere
The whitening and opacifying properties of titanium dioxide (TiO2) are commonly exploited when it is used as a food additive (E171). However, the safety of this additive can be questioned as TiO2 nanoparticles (TiO2-NPs) have been classed at potentially toxic. This study aimed to shed some light on the mechanisms behind the potential toxicity of E171 on epithelial intestinal cells, using two in vitro models: (i) a monoculture of differentiated Caco-2 cells and (ii) a coculture of Caco-2 with HT29-MTX mucus-secreting cells...
July 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28661943/internet-stroke-preparedness-for-african-american-women
#17
Claudia C Beal
BACKGROUND: African American women exhibit low stroke awareness and may benefit from experiential and lay language description of stroke symptoms. OBJECTIVES: The purpose of this pilot study was to examine the effect of an online stroke preparedness intervention for identification of stroke symptoms and appropriate action in response to suspected stroke and estimate effect sizes for a larger study. METHODS: A quasi-experimental nonequivalent comparison group design was used to randomized 44 women to intervention (n = 23) or wait-list control group (n = 21)...
August 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28660715/climate-change-vulnerability-for-species-assessing-the-assessments
#18
Christopher J Wheatley, Colin M Beale, Richard B Bradbury, James W Pearce-Higgins, Rob Critchlow, Chris D Thomas
Climate change vulnerability assessments are commonly used to identify species at risk from global climate change, but the wide range of methodologies available makes it difficult for end users, such as conservation practitioners or policymakers, to decide which method to use as a basis for decision-making. In this study, we evaluate whether different assessments consistently assign species to the same risk categories and whether any of the existing methodologies perform well at identifying climate-threatened species...
June 29, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28660558/morphometric-changes-in-the-spinal-cord-during-prenatal-life-a-stereological-study-in-sheep
#19
Javad Sadeghinezhad, Narges Zadsar, Beal Hasanzadeh
This study describes the volumetric changes in the spinal cord during prenatal life in sheep using quantitative stereological methods. Twenty healthy sheep fetuses were included in the present study, divided into four groups representing 9-11, 12-14, 15-17, and 18-20 weeks of gestation. In each group, the spinal cord was dissected out and sampled according to the unbiased systematic random sampling method then used for stereological estimations. The total volume of spinal cord, volume of gray matter (GM), volume of white matter (WM), ratio of GM volume to WM volume, and volume of central canal (CC) were estimated in the whole spinal cord and its various regions using Cavalieri's principle...
June 28, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28654449/neonatal-male-circumcision-still-a-controversy
#20
Judy A Beal
No abstract text is available yet for this article.
July 2017: MCN. the American Journal of Maternal Child Nursing
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