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Judy A Beal
No abstract text is available yet for this article.
November 2016: MCN. the American Journal of Maternal Child Nursing
Christopher M Celano, Eleanor E Beale, Scott R Beach, Arianna M Belcher, Laura Suarez, Shweta R Motiwala, Parul U Gandhi, Hanna Gaggin, James L Januzzi, Brian C Healy, Jeff C Huffman
OBJECTIVE: Psychological constructs are associated with cardiovascular health, but the biological mechanisms mediating these relationships are unknown. We examined relationships between psychological constructs and markers of inflammation, endothelial function, and myocardial strain in a cohort of post-acute coronary syndrome (ACS) patients. METHODS: Participants (N = 164) attended study visits 2 weeks and 6 months after ACS. During these visits, they completed self-report measures of depressive symptoms, anxiety, optimism, and gratitude; and blood samples were collected for measurement of biomarkers reflecting inflammation, endothelial function, and myocardial strain...
September 30, 2016: Psychosomatic Medicine
Emilia Ip, Adrian M J Pokorny, Stephen Della-Fiorentina, Philip Beale, Victoria Bray, Belinda E Kiely, Prunella Blinman
BACKGROUND: Octogenarians represent a growing population reviewed in medical oncology clinics, yet there is a paucity of data on how chemotherapy is tolerated in this age group. AIM: To describe the use of palliative first-line chemotherapy in patients 80 years and over, and factors associated with its use. METHODS: We identified all new patients aged 80 years or older diagnosed with incurable advanced solid organ cancer, and seen in one of three Sydney medical oncology outpatient clinics between January 2009 and December 2013...
October 17, 2016: Internal Medicine Journal
Emily F Law, Jessica L Fales, Sarah E Beals-Erickson, Alessandro Failo, Deirdre Logan, Edin Randall, Karen Weiss, Lindsay Durkin, Tonya M Palermo
OBJECTIVE : To adapt problem-solving skills training (PSST) for parents of children receiving intensive pain rehabilitation and evaluate treatment feasibility, acceptability, and satisfaction. METHODS : Using a prospective single-arm case series design, we evaluated the feasibility of delivering PSST to 26 parents (84.6% female) from one of three pediatric pain rehabilitation programs. Parents completed four to six sessions of PSST delivered during a 2-4-week period. A mixed-methods approach was used to assess treatment acceptability and satisfaction...
October 15, 2016: Journal of Pediatric Psychology
Motasem Melhem, Mohamed Abu-Farha, Dinu Antony, Ashraf Al Madhoun, Chiara Bacchelli, Fadi Alkayal, Irina AlKhairi, Sumi John, Mohamad Alomari, Phillip L Beales, Osama Alsmadi
OBJECTIVE: To characterize the underlying genetic and molecular defects in a consanguineous family with life-long blood disorder manifested with thrombocytopenia (low platelets count) and anemia. METHODS: Genetic linkage analysis, exome sequencing and functional genomics were carried out to identify and characterize the defective gene. RESULTS: We identification of a novel truncation mutation (p.C108*) in Chromosome 6 Open Reading Frame 25 (C6orf25) gene in this family...
October 15, 2016: European Journal of Haematology
Matthew D Beal, Dimitri Delagrammaticas, David Fitz
No abstract text is available yet for this article.
October 14, 2016: Journal of Orthopaedic Surgery and Research
Emre A Eren, Nicholas Latchana, Eliza Beal, Don Hayes, Bryan Whitson, Sylvester M Black
The supply of liver grafts for treatment of end-stage liver disease continues to fall short of ongoing demands. Currently, most liver transplants originate from donations after brain death. Enhanced utilization of the present resources is prudent to address the needs of the population. Donation after circulatory or cardiac death is a mechanism whereby the availability of organs can be expanded. Donations after circulatory death pose unique challenges given their exposure to warm ischemia. Technical principles of donations after circulatory death procurement and pertinent studies investigating patient outcomes, graft outcomes, and complications are highlighted in this review...
October 2016: Experimental and Clinical Transplantation
Rachel Anne Valenzuela, Kazumitsu Onizuka, Alexi Ball-Jones, Tiannan Hu, Scott Ryan Suter, Peter A Beal
Short interfering RNA (siRNA)-triggered gene knockdown via the RNA interference (RNAi) pathway is widely used to study gene function and siRNA-based therapeutics are in development.However, since the guide strand of an siRNA can function like a natural microRNA (miRNA), siRNAs often repress hundreds of off-target transcripts with complementary only to the seed region (nucleotides 2-8) of the guide strand. Here we describe novel guide strand 3' end modifications derived from 1-ethynylribose and copper-catalyzed azide/alkyne cycloaddition reactions and evaluate their impact on target vs miRNA-like off-target knockdown...
October 12, 2016: Chembiochem: a European Journal of Chemical Biology
S J Jacober, M J Prince, J M Beals, M L Hartman, Y Qu, H Linnebjerg, P Garhyan, A Haupt
Basal insulin peglispro (BIL) is a novel basal insulin with a flat, prolonged activity profile. BIL has been demonstrated in a dog model, in healthy men and in patients with type 1 diabetes (T1D) to have significant hepato-preferential action resulting from reduced peripheral activity. In the IMAGINE-Phase 3 clinical trial program, more than 6000 patients were included, of whom ~3900 received BIL. Of the 7 pivotal IMAGINE trials, 3 studies were double-blinded and 3 were in T1D patients. BIL consistently demonstrated a greater HbA1c reduction, less glycaemic variability and a clinically relevant reduction in the rates of nocturnal hypoglycaemia across comparator [glargine and isophane insulin (NPH)] studies...
October 2016: Diabetes, Obesity & Metabolism
Judy A Beal
No abstract text is available yet for this article.
July 2016: MCN. the American Journal of Maternal Child Nursing
Maleeha Maria, Ideke J C Lamers, Miriam Schmidts, Muhammad Ajmal, Sulman Jaffar, Ehsan Ullah, Bilal Mustafa, Shakeel Ahmad, Katia Nazmutdinova, Bethan Hoskins, Erwin van Wijk, Linda Koster-Kamphuis, Muhammad Imran Khan, Phil L Beales, Frans P M Cremers, Ronald Roepman, Maleeha Azam, Heleen H Arts, Raheel Qamar
Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder that is both genetically and clinically heterogeneous. To date 19 genes have been associated with BBS, which encode proteins active at the primary cilium, an antenna-like organelle that acts as the cell's signaling hub. In the current study, a combination of mutation screening, targeted sequencing of ciliopathy genes associated with BBS, and whole-exome sequencing was used for the genetic characterization of five families including four with classic BBS symptoms and one BBS-like syndrome...
October 6, 2016: Scientific Reports
Ursula Running Bear, Janette Beals, Douglas K Novins, Spero M Manson
BACKGROUND: Little is known about factors associated with detoxification treatment completion and the transition to substance abuse treatment following detoxification among Alaska Native people. This study examined 3 critical points on the substance abuse continuum of care (alcohol detoxification completion, acceptance of referral to substance abuse treatment, entry into substance abuse treatment following detoxification). METHODS: The retrospective cohort included 383 adult Alaska Native patients admitted to a tribally owned and managed inpatient detoxification unit...
September 24, 2016: Addictive Behaviors
Eliza W Beal, Dmitry Tumin, Lanla F Conteh, A James Hanje, Anthony J Michaels, Don Hayes, Sylvester M Black, Khalid Mumtaz
There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes. The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013. Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and length of stay were compared between nonobese recipients receiving a graft from nonobese donors and obese recipient-obese donor, obese recipient-nonobese donor, and nonobese recipient-obese donor pairs...
2016: Journal of Transplantation
Kourtney L Beale
No abstract text is available yet for this article.
October 2016: American Journal of Nursing
Eliza W Beal, Lai Wei, Cecilia G Ethun, Sylvester M Black, Mary Dillhoff, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Stefan Buettner, Timothy M Pawlik, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt
BACKGROUND: Gallbladder and extrahepatic biliary malignancies are aggressive tumors with high risk of recurrence and death. We hypothesize that elevated preoperative Neutrophil-Lymphocyte Ratios (NLR) are associated with poor prognosis among patients undergoing resection of gallbladder or extrahepatic biliary cancers. METHODS: Patients who underwent complete surgical resection between 2000-2014 were identified from 10 academic centers (n=525). Overall (OS) and recurrence-free survival (RFS) were analyzed by stratifying patients with normal (<5) versus elevated (>5) NLR...
September 24, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
J Ma, J Setton, P Blecua Carrillo Albornoz, C A Barker, B H Lok, K Beal, S N Powell, N Lee, T A Chan, N Riaz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Z A Kohutek, R G Blasberg, J Humm, L E Blumberg, C W Brennan, V Tabar, P H Gutin, B Beattie, M Rosenblum, J T Huse, H Schoder, K Beal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
P W Sperduto, W Jiang, P D Brown, S E Braunstein, P K Sneed, D A Wattson, H A Shih, A Bangdiwala, R Shanley, N A Lockney, K Beal, E Lou, T Amatruda, W A Sperduto, J P Kirkpatrick, N Yeh, L E Gaspar, J K Molitoris, L Masucci, D Roberge, J B Yu, V L Chiang, M P Mehta
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
N A Lockney, X Pei, L E Blumberg, T A Chan, Y Yamada, T J Yang, K Beal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
E S Anderson, M A Postow, R Young, T A Chan, Y Yamada, K Beal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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