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https://www.readbyqxmd.com/read/28513862/liver-transplantation-for-unresectable-colorectal-liver-metastases-a-systematic-review
#1
REVIEW
Dimitrios Moris, Diamantis I Tsilimigras, Jeffery Chakedis, Eliza W Beal, Evangelos Felekouras, Spiridon Vernadakis, Dimitrios Schizas, John J Fung, Timothy M Pawlik
The use of liver transplantation (LT) for liver metastases attempted in the early 1990's was associated with poor perioperative outcomes and unacceptably low overall survival. Recently, there has been renewed interest in LT as a treatment option for colorectal liver metastases (CLM) in countries where organ supply is high. To date, no meticulous analysis about the efficacy, safety and outcomes of LT in CLM patients has been published. We present the first systematic review on the subject.
May 17, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28511632/mislabeling-of-study-design-and-overstatement-of-findings-in-rechallenging-statin-therapy-in-veterans-with-statin-induced-myopathy-post-vitamin-d-replenishment
#2
https://www.readbyqxmd.com/read/28498256/paragon-anzgog-0903-phase-2-study-of-anastrozole-in-women-with-estrogen-or-progesterone-receptor-positive-platinum-resistant-or-refractory-recurrent-ovarian-cancer
#3
Anthony Bonaventura, Rachel L OʼConnell, Cristina Mapagu, Philip J Beale, Orla M McNally, Linda R Mileshkin, Peter T Grant, Alison M Hadley, Jeffery C H Goh, Katrin M Sjoquist, Julie Martyn, Anna DeFazio, James Scurry, Michael L Friedlander
BACKGROUND: There is some evidence that a subset of patients with recurrent ovarian cancer may benefit from antiestrogen therapy. The Paragon study is a basket protocol that includes a series of phase 2 trials investigating the activity of anastrozole in patients with estrogen or progesterone receptor-positive recurrent gynecological cancers. We report the results of treatment in patients with platinum-resistant or -refractory recurrent epithelial ovarian cancer. METHODS: Postmenopausal women who had estrogen and/or progesterone receptor-positive platinum-resistant or platinum-refractory recurrent ovarian cancer and disease measurable by Response Evaluation Criteria In Solid Tumors (RECIST) version 1...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28497252/gallbladder-cancer-presenting-with-jaundice-uniformly-fatal-or-still-potentially-curable
#4
Thuy B Tran, Jeffrey A Norton, Cecilia G Ethun, Timothy M Pawlik, Stefan Buettner, Carl Schmidt, Eliza W Beal, William G Hawkins, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Kamran Idrees, Chelsea A Isom, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, George A Poultsides
BACKGROUND: Jaundice as a presenting symptom of gallbladder cancer has traditionally been considered to be a sign of advanced disease, inoperability, and poor outcome. However, recent studies have demonstrated that a small subset of these patients can undergo resection with curative intent. METHODS: Patients with gallbladder cancer managed surgically from 2000 to 2014 in 10 US academic institutions were stratified based on the presence of jaundice at presentation (defined as bilirubin ≥4 mg/ml or requiring preoperative biliary drainage)...
May 11, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28492819/inappropriate-comparator-group-in-study-of-selective-serotonin-reuptake-inhibitors-and-risk-for-intracranial-hemorrhage
#5
David Jeffrey Beale
No abstract text is available yet for this article.
May 8, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28491476/increased-intracranial-pressure-in-the-setting-of-enterovirus-and-other-viral-meningitides
#6
Jules C Beal
Increased intracranial pressure due to viral meningitis has not been widely discussed in the literature, although associations with Varicella and rarely Enterovirus have been described. Patients with increased intracranial pressure and cerebrospinal fluid analysis suggestive of a viral process are sometimes classified as having atypical idiopathic intracranial hypertension (IIH). However, a diagnosis of IIH requires normal cerebrospinal fluid, and therefore in these cases an infection with secondary intracranial hypertension may be a more likely diagnosis...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28489815/common-genetic-variation-drives-molecular-heterogeneity-in-human-ipscs
#7
Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver J Culley, Petr Danecek, Adam Faulconbridge, Peter W Harrison, Annie Kathuria, Davis McCarthy, Shane A McCarthy, Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal Patel, Alistair White, Sharad R Patel, Laura Clarke, Reena Halai, Christopher M Kirton, Anja Kolb-Kokocinski, Philip Beales, Ewan Birney, Davide Danovi, Angus I Lamond, Willem H Ouwehand, Ludovic Vallier, Fiona M Watt, Richard Durbin, Oliver Stegle, Daniel J Gaffney
Induced pluripotent stem cell (iPSC) technology has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterisation of many existing iPSC lines limits their potential use for research and therapy. Here, we describe the systematic generation, genotyping and phenotyping of 711 iPSC lines derived from 301 healthy individuals by the Human Induced Pluripotent Stem Cells Initiative (HipSci: http://www.hipsci.org). Our study outlines the major sources of genetic and phenotypic variation in iPSCs and establishes their suitability as models of complex human traits and cancer...
May 10, 2017: Nature
https://www.readbyqxmd.com/read/28488403/drug-eluting-stents-for-very-long-lesions-go-long-but-know-the-risks
#8
EDITORIAL
Charles E Beale, J Dawn Abbott
Long coronary artery lesions are increasingly treated with new technologies including current generation drug eluting stents (DES) despite a lack of robust data on outcomes. In the current study, patients receiving Xience V DES for very long lesions (>35 mm) compared to lesions 25-35 mm had similar outcomes. Future research should address late outcomes, stent thrombosis rates, as well as investigation of lesions greater than 60 mm.
May 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28481571/examination-of-real-time-fluctuations-in-suicidal-ideation-and-its-risk-factors-results-from-two-ecological-momentary-assessment-studies
#9
Evan M Kleiman, Brianna J Turner, Szymon Fedor, Eleanor E Beale, Jeff C Huffman, Matthew K Nock
Two studies examined 2 important but previously unanswered questions about the experience of suicidal ideation: (a) How does suicidal ideation vary over short periods of time?, and (b) To what degree do risk factors for suicidal ideation vary over short periods and are such changes associated with changes in suicidal ideation? Participants in Study 1 were 54 adults who had attempted suicide in the previous year and completed 28 days of ecological momentary assessment (EMA; average of 2.51 assessments per day; 2,891 unique assessments)...
May 8, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28452274/an-innovative-approach-to-hydration-for-a-patient-with-dementia
#10
Adam Beales
Nursing older people in acute settings involves the provision of complex care, including the maintenance of good hydration. Dehydration is a serious condition that may contribute to the development of pressure ulcers, urinary tract infections, acute kidney injury and venous thromboembolism. If oral hydration methods are not successful, the alternatives are intravenous (IV) or subcutaneous fluid hydration therapy. These are invasive methods and may not be tolerated by all patients. This article uses a case study to explore an innovative approach to oral hydration...
April 28, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28449982/cerebral-developmental-venous-anomaly-does-it-prevent-stroke-in-acute-sinus-thrombosis
#11
Ajay Goenka, William Gomes, Jules C Beal
No abstract text is available yet for this article.
March 31, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28448335/cry-it-out-what-is-it-and-is-it-appropriate
#12
Judy A Beal
No abstract text is available yet for this article.
May 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28447976/method-of-direct-segmental-intra-hepatic-delivery-using-a-rat-liver-hilar-clamp-model
#13
Eliza W Beal, Curtis Dumond, Jung-Lye Kim, Khalid Mumtaz, Don Hayes, Ken Washburn, Bryan A Whitson, Sylvester M Black
Major hepatic surgery with inflow occlusion, and liver transplantation, necessitate a period of warm ischemia, and a period of reperfusion leading to ischemia/reperfusion (I/R) injury with myriad negative consequences. Potential I/R injury in marginal organs destined for liver transplantation contributes to the current donor shortage secondary to a decreased organ utilization rate. A significant need exists to explore hepatic I/R injury in order to mediate its impact on graft function in transplantation. Rat liver hilar clamp models are used to investigate the impact of different molecules on hepatic I/R injury...
April 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28439593/reversible-restructuring-of-supported-au-nanoparticles-during-butadiene-hydrogenation-revealed-by-operando-gisaxs-giwaxs
#14
David James Martin, Donato Decarolis, Yaroslav I Odarchenko, Jennifer J Herbert, Thomas Arnold, Jonathan Rawle, Chris Nicklin, Hans-Gerd Boyen, Andrew M Beale
Periodically arranged, monodisperse gold nanoparticles supported on flat silicon substrates were studied for the hydrogenation of 1,3-butadiene under operando conditions using Grazing Incidence Small- and Wide-Angle X-ray Scattering (GISAXS/GIWAXS). It was found that the composition and shape of the nanoparticles depends very much on the chemical environment; the particles are shown to be dynamic, undergoing reversible size and shape change particularly during catalytic reaction, highlighting a dynamism often not observed in traditional studies...
May 4, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28434835/use-of-a-bicortical-button-to-safely-repair-the-distal-biceps-in-a-two-incision-approach-a-cadaveric-analysis
#15
Jonathan D Barlow, Ryan J McNeilan, Amy Speeckaert, Corey T Beals, Hisham M Awan
PURPOSE: No consensus has been reached on the most effective anatomic approach or fixation method for distal biceps repair. It is our hypothesis that, using a cortical biceps button through a 2-incision technique, the distal biceps can be safely and anatomically repaired. METHODS: A 2-incision biceps button distal biceps repair was completed on 10 fresh-frozen cadavers. The proximity of the guide pin to the critical structures of the forearm, including the posterior interosseous nerve and recurrent radial artery, was measured...
April 20, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28428600/water-fluoridation-there-is-no-evidence
#16
J F Beal, M Lennon
No abstract text is available yet for this article.
April 21, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28422998/reducing-dna-context-dependence-in-bacterial-promoters
#17
Swati B Carr, Jacob Beal, Douglas M Densmore
Variation in the DNA sequence upstream of bacterial promoters is known to affect the expression levels of the products they regulate, sometimes dramatically. While neutral synthetic insulator sequences have been found to buffer promoters from upstream DNA context, there are no established methods for designing effective insulator sequences with predictable effects on expression levels. We address this problem with Degenerate Insulation Screening (DIS), a novel method based on a randomized 36-nucleotide insulator library and a simple, high-throughput, flow-cytometry-based screen that randomly samples from a library of 436 potential insulated promoters...
2017: PloS One
https://www.readbyqxmd.com/read/28399168/global-trends-in-dietary-micronutrient-supplies-and-estimated-prevalence-of-inadequate-intakes
#18
Ty Beal, Eric Massiot, Joanne E Arsenault, Matthew R Smith, Robert J Hijmans
Understanding dietary patterns is vital to reducing the number of people experiencing hunger (about 795 million), micronutrient deficiencies (2 billion), and overweight or obesity (2.1 billion). We characterize global trends in dietary quality by estimating micronutrient density of the food supply, prevalence of inadequate intake of 14 micronutrients, and average prevalence of inadequate intake of these micronutrients for all countries between 1961 and 2011. Over this 50-year period, the estimated prevalence of inadequate intakes of micronutrients has declined in all regions due to increased total production of food and/or micronutrient density...
2017: PloS One
https://www.readbyqxmd.com/read/28397999/scalp-eeg-ictal-gamma-and-beta-activity-during-infantile-spasms-evidence-of-focality
#19
Hiroki Nariai, Jules Beal, Aristea S Galanopoulou, Wenzhu B Mowrey, Stephan Bickel, Yoshimi Sogawa, Rana Jehle, Shlomo Shinnar, Solomon L Moshé
OBJECTIVE: We investigated temporal and spatial characteristics of ictal gamma and beta activity on scalp EEG during spasms in patients with West syndrome (WS) to evaluate potential focal cortical onset. METHODS: A total of 1,033 spasms from 34 patients with WS of various etiologies were analyzed on video-electroencephalography (EEG) using time-frequency analysis. Ictal gamma (35-90 Hz) and beta (15-30 Hz) activities were correlated with visual symmetry of spasms, objective EMG (electromyography) analysis, and etiology of WS...
May 2017: Epilepsia
https://www.readbyqxmd.com/read/28394459/ergogenic-properties-of-metformin-in-simulated-high-altitude
#20
Rebecca L Scalzo, Hunter L Paris, Scott E Binns, Janelle L Davis, Joseph W Beals, Christopher L Melby, Gary J Luckasen, Matthew S Hickey, Benjamin F Miller, Karyn L Hamilton, Christopher Bell
Metformin augments glucose/glycogen regulation and may acutely promote fatigue resistance during high-intensity exercise. In hypobaric environments, such as high altitude, the important contribution of carbohydrates to physiological function is accentuated as glucose/glycogen dependence is increased. Because hypoxia/hypobaria decreases insulin sensitivity, replenishing skeletal muscle glycogen in high altitude becomes challenging and subsequent physical performance may be compromised. We hypothesized that in conditions where glycogen repletion was critical to physical outcomes, metformin would attenuate hypoxia-mediated decrements in exercise performance...
April 10, 2017: Clinical and Experimental Pharmacology & Physiology
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