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https://www.readbyqxmd.com/read/29236711/magnetic-resonance-imaging-of-the-hand-and-wrist-in-a-randomized-double-blind-multicenter-placebo-controlled-trial-of-infliximab-for-rheumatoid-arthritis-comparison-of-dynamic-contrast-enhanced-assessments-with-semi-quantitative-scoring
#1
Chan Beals, Richard Baumgartner, Charles Peterfy, Andra Balanescu, Gavrila Mirea, Alexandru Harabagiu, Serghei Popa, Amy Cheng, Dai Feng, Edward Ashton, Julie DiCarlo, Marie-Helene Vallee, Bernard J Dardzinski
The objective of this study was to compare the scope and the discriminative power of Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) to those of semi-quantitative MRI scoring for evaluating treatments for rheumatoid arthritis (RA) in multicenter randomized clinical trials (RCTs). Sixty-one patients with active RA participated in a double-blind, parallel group, randomized, multicenter methodology study receiving infliximab or placebo through 14 weeks. The most symptomatic wrist and metacarpophalangeal joints (MCPs) were imaged using MRI...
2017: PloS One
https://www.readbyqxmd.com/read/29232001/novel-sequence-variants-in-the-mkks-gene-cause-bardet-biedl-syndrome-with-intra-and-inter-familial-variable-phenotypes
#2
Asmat Ullah, Maryam Khalid, Muhammad Umair, Sher Alam Khan, Muhammad Bilal, Saadullah Khan, Wasim Ahmad
Bardet-Biedl Syndrome (BBS) is a multisystem disorder involving retina, kidney, limbs and nervous system. Additional features associated with BBS include dental anomalies, cardiovascular defects, hearing loss and speech impairment (Beales et al. 199; Ullah and Umair et al. 2017). Diagnosis of BBS is based on the presence of four out of six primary or three primary and two secondary phenotypes.
December 12, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/29227730/physical-and-performance-characteristics-related-to-unintentional-musculoskeletal-injury-in-special-forces-operators-a-prospective-analysis
#3
Nicholas R Heebner, John P Abt, Mita Lovalekar, Kim Beals, Timothy C Sell, Jeffery Morgan, Shawn Kane, Scott Lephart
CONTEXT:   Seventy-seven percent of musculoskeletal injuries sustained by United States Army Special Forces Operators are preventable. Identification of predictive characteristics will promote the development of screening methods to augment injury-prevention programs. OBJECTIVE:   To determine physical and performance characteristics that predict musculoskeletal injuries. SETTING:   Clinical laboratory. PATIENTS OR OTHER PARTICIPANTS:   A total of 95 Operators (age = 32...
December 11, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29218105/systemic-inflammation-is-associated-with-myocardial-fibrosis-diastolic-dysfunction-and-cardiac-hypertrophy-in-patients-with-hypertrophic-cardiomyopathy
#4
Lu Fang, Andris H Ellims, Anna L Beale, Andrew J Taylor, Andrew Murphy, Anthony M Dart
BACKGROUND: Regional or diffuse fibrosis is an early feature of hypertrophic cardiomyopathy (HCM) and is related to poor prognosis. Previous studies have documented low-grade inflammation in HCM. The aim of this study was to examine the relationships between circulating inflammatory markers and myocardial fibrosis, systolic and diastolic dysfunction, and the degree of cardiac hypertrophy in HCM patients. METHODS AND RESULTS: Fifty HCM patients were recruited while 20 healthy subjects served as the control group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215427/13-reasons-why-a-trigger-for-teen-suicide
#5
Judy A Beal
No abstract text is available yet for this article.
January 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29212317/targeted-measurements-of-o-and-n-glycopeptides-show-that-proteins-in-hdl-particles-are-enriched-with-specific-glycosylation-compared-to-plasma
#6
Muchena J Kailemia, Wanghui Wei, Khoa Nguyen, Elizabeth Beals, Lisa Sawrey-Kubicek, Christopher Rhodes, Chenghao Zhu, Romina Sacchi, Angela M Zivkovic, Carlito B Lebrilla
High density lipoprotein (HDL) particles are believed to be protective due to their inverse correlation with the prevalence of cardiovascular diseases. However, recent studies show that in some conditions such as heart disease and diabetes, HDL particles can become dysfunctional. Great attention has been directed toward HDL particle composition because the relative abundances of HDL constituents determine HDL's functional properties. A key factor to consider when studying the structure and composition of plasma particles is the protein glycosylation...
December 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29205351/oncologic-effects-of-preoperative-biliary-drainage-in-resectable-hilar-cholangiocarcinoma-percutaneous-biliary-drainage-has-no-adverse-effects-on-survival
#7
Xu-Feng Zhang, Eliza W Beal, Katiuscha Merath, Cecilia G Ethun, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Matthew Weiss, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: The objective of the current study was to define long-term survival of patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic biliary drainage (EBD). METHODS: Between 2000 and 2014, 240 patients who underwent curative-intent resection for HCCA were identified at 10 major hepatobiliary centers. Postoperative morbidity and mortality, as well as disease-specific survival (DSS) and recurrence-free survival (RFS) were analyzed among patients...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29202501/assessment-of-t2-relaxation-times-for-normal-canine-knee-articular-cartilage-by-t2-mapping-using-1-5-t-magnetic-resonance-imaging
#8
Asami Matsui, Miki Shimizu, Brian Beale, Fumitaka Takahashi, Sinya Yamaguchi
Objectives This study aims to assess and compare the T2 relaxation times for articular cartilage of normal canine stifle joints in four regions by T2 mapping using a 1.5-T magnetic resonance imaging (MRI). Methods In vivo prospective study: 20 hindlimbs (left and right) from 10 normal healthy beagle dogs (n = 20). The region of interest (ROI) was subdivided into medial and lateral condyles of femoral cartilage (MF and LF, respectively) and medial and lateral condyles of tibial cartilage (MT and LT, respectively)...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29198365/update-on-current-problems-in-colorectal-liver-metastasis
#9
Jeffrey Chakedis, Malcolm H Squires, Eliza W Beal, Tasha Hughes, Heather Lewis, Anghela Paredes, Mazen Al-Mansour, Steven Sun, Jordan M Cloyd, Timothy M Pawlik
No abstract text is available yet for this article.
November 2017: Current Problems in Surgery
https://www.readbyqxmd.com/read/29193532/future-orientation-in-adolescent-and-young-adult-cancer-survivors-and-unaffected-peers
#10
Sarah J Beal, Rachel Tillery, Yelena P Wu, Aimee N Thompson, Ahna Pai
No abstract text is available yet for this article.
November 28, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29193010/early-versus-late-recurrence-of-intrahepatic-cholangiocarcinoma-after-resection-with-curative-intent
#11
X-F Zhang, E W Beal, F Bagante, J Chakedis, M Weiss, I Popescu, H P Marques, L Aldrighetti, S K Maithel, C Pulitano, T W Bauer, F Shen, G A Poultsides, O Soubrane, G Martel, B G Koerkamp, E Itaru, T M Pawlik
BACKGROUND: The objective of this study was to investigate the characteristics, treatment and prognosis of early versus late recurrence of intrahepatic cholangiocarcinoma (ICC) after hepatic resection. METHODS: Patients who underwent resection with curative intent for ICC were identified from a multi-institutional database. Data on clinicopathological characteristics, initial operative details, timing and sites of recurrence, recurrence management and long-term outcomes were analysed...
November 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29188764/assessing-the-performance-of-methodological-search-filters-to-improve-the-efficiency-of-evidence-information-retrieval-five-literature-reviews-and-a-qualitative-study
#12
Carol Lefebvre, Julie Glanville, Sophie Beale, Charles Boachie, Steven Duffy, Cynthia Fraser, Jenny Harbour, Rachael McCool, Lynne Smith
BACKGROUND: Effective study identification is essential for conducting health research, developing clinical guidance and health policy and supporting health-care decision-making. Methodological search filters (combinations of search terms to capture a specific study design) can assist in searching to achieve this. OBJECTIVES: This project investigated the methods used to assess the performance of methodological search filters, the information that searchers require when choosing search filters and how that information could be better provided...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29179554/a-comparison-between-experimental-and-broken-symmetry-density-functional-theory-bs-dft-calculated-electron-paramagnetic-resonance-epr-parameters-of-the-s2-state-of-the-oxygen-evolving-complex-of-photosystem-ii-in-its-native-calcium-and-strontium-substituted
#13
Nathan J Beal, Thomas A Corry, Patrick J O'Malley
A comparison between experimental and Broken Symmetry Density Functional Theory (BS-DFT) calculated hyperfine couplings for the S2 state of the oxygen evolving complex (OEC) has been performed. The effect of Ca substitution by Sr combined with the protonation state of two terminal hydroxo or water ligands, W1 and W2, on the calculated hyperfine couplings of 55Mn, 13C, 14N, 17O and 1H nuclei has been investigated. Our findings show best agreement for OEC models which contain a hydroxo group at the W2 position and a water molecule at W1...
November 27, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29178025/pegylated-liposomal-irinotecan-hydrochloride-trihydrate-for-treating-pancreatic-cancer-after-gemcitabine-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#14
REVIEW
Nigel Fleeman, Ahmed Abdulla, Adrian Bagust, Sophie Beale, Marty Richardson, Angela Stainthorpe, Angela Boland, Eleanor Kotas, Joanne McEntee, Daniel Palmer
The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Shire Pharmaceuticals) of pegylated liposomal irinotecan hydrochloride trihydrate (liposomal irinotecan) to submit clinical and cost-effectiveness evidence for its use in combination with 5-fluorouracil (5-FU) and folic acid/leucovorin (LV) for treating patients with pancreatic cancer following prior treatment with gemcitabine as part of the institute's Single Technology Appraisal process. The Liverpool Reviews and Implementation Group at the University of Liverpool was commissioned to act as the Evidence Review Group (ERG)...
November 24, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29177774/surgical-treatment-of-periprosthetic-femoral-fractures-a-retrospective-study-with-functional-and-radiological-outcomes-from-2010-to-2016
#15
Gaetano Caruso, Lorenzo Milani, Tedi Marko, Vincenzo Lorusso, Mattia Andreotti, Leo Massari
BACKGROUND: The treatment of periprosthetic femoral fractures is a great challenge for the orthopedic surgeon and requires a knowledge of bone fracture fixation as well as skills and experience in revision surgery. The aim of this retrospective study was to evaluate the functional and radiological outcomes of periprosthetic femoral fractures surgically treated in our department from 2010 to 2016. MATERIALS AND METHODS: This study involved 73 patients with a periprosthetic femoral fracture after total hip arthroplasty or hemiarthroplasty...
November 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29176591/identifying-metabolites-by-integrating-metabolome-databases-with-mass-spectrometry-cheminformatics
#16
Zijuan Lai, Hiroshi Tsugawa, Gert Wohlgemuth, Sajjan Mehta, Matthew Mueller, Yuxuan Zheng, Atsushi Ogiwara, John Meissen, Megan Showalter, Kohei Takeuchi, Tobias Kind, Peter Beal, Masanori Arita, Oliver Fiehn
Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with biological metadata across over 110,000 samples; MS-DIAL 2.0, a software tool for chromatographic deconvolution of high-resolution GC-MS or liquid chromatography-mass spectrometry (LC-MS); and MS-FINDER 2.0, a structure-elucidation program that uses a combination of 14 metabolome databases in addition to an enzyme promiscuity library...
November 27, 2017: Nature Methods
https://www.readbyqxmd.com/read/29176034/selenium-preserves-keratinocyte-stemness-and-delays-senescence-by-maintaining-epidermal-adhesion
#17
Lara Jobeili, Patricia Rousselle, David Béal, Eric Blouin, Anne-Marie Roussel, Odile Damour, Walid Rachidi
Skin is constantly exposed to environmental factors such as pollutants, chemicals and ultra violet radiation (UV), which can induce premature skin aging and increase the risk of skin cancer. One strategy to reduce the effect of oxidative stress produced by environmental exposure is the application of antioxidant molecules. Among the endogenous antioxidants, selenoproteins play a key role in antioxidant defense and in maintaining a reduced cellular environment. Selenium, essential for the activity of selenoproteins, is a trace element that is not synthesized by organisms and must be supplied by diet or supplementation...
November 25, 2017: Aging
https://www.readbyqxmd.com/read/29175905/x-ray-physico-chemical-imaging-during-activation-of-cobalt-based-fischer-tropsch-synthesis-catalysts
#18
Andrew M Beale, Simon D M Jacques, Marco Di Michiel, J Frederick W Mosselmans, Stephen W T Price, Pierre Senecal, Antonios Vamvakeros, James Paterson
The imaging of catalysts and other functional materials under reaction conditions has advanced significantly in recent years. The combination of the computed tomography (CT) approach with methods such as X-ray diffraction (XRD), X-ray fluorescence (XRF) and X-ray absorption near-edge spectroscopy (XANES) now enables local chemical and physical state information to be extracted from within the interiors of intact materials which are, by accident or design, inhomogeneous. In this work, we follow the phase evolution during the initial reduction step(s) to form Co metal, for Co-containing particles employed as Fischer-Tropsch synthesis (FTS) catalysts; firstly, working at small length scales (approx...
January 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29175303/egfr-kras-braf-and-her2-testing-in-metastatic-lung-adenocarcinoma-value-of-testing-on-samples-with-poor-specimen-adequacy-and-analysis-of-discrepancies
#19
Fabien Forest, Marie-Laure Stachowicz, François Casteillo, Georgia Karpathiou, Fabienne Gouzy-Grosjean, Colette Guilaubey, Michèle Cottier, Julie Beal, Alix Clemenson, Michel Péoc'h
Molecular testing on metastatic lung adenocarcinoma or on non-small cell non-squamous lung carcinoma often relies on small specimen. In this group of patient with poor specimen adequacy, we analyzed the rate of EGFR, KRAS, BRAF and HER2 mutations compared to their rate in optimal specimen. We analyzed discrepancies in molecular testing results in patients with iterative analysis on several samples. We performed a retrospective study of 1538 samples consecutively analyzed. 263/665 (39,5%) biopsies and 37/708 (5,2%) surgical specimens were considered as samples with poor specimen adequacy (p<0,0001)...
November 22, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29174509/tlr8-activation-and-inhibition-by-guanosine-analogs-in-rna-importance-of-functional-groups-and-chain-length
#20
Tiannan Hu, Scott R Suter, Madeline M Mumbleau, Peter A Beal
Toll-like receptor 8 (TLR8) is an important component of the human innate immune system that recognizes single stranded RNA (ssRNA). Recent X-ray crystal structures of TLR8 bound to ssRNA revealed a previously unrecognized binding site for a 5'-UpG-3' dinucleotide. Here we use an atomic mutagenesis strategy coupled with a cellular TLR8 activation assay to probe the importance of specific functional groups present on the guanine base in RNA-mediated receptor agonism and antagonism. Results from RNA analogs containing 7-deazaguanosine, 2-aminopurine and inosine confirm the importance of guanine N7, O6 and N2, respectively, in TLR8 activation...
November 11, 2017: Bioorganic & Medicinal Chemistry
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