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https://www.readbyqxmd.com/read/28434835/use-of-a-bicortical-button-to-safely-repair-the-distal-biceps-in-a-two-incision-approach-a-cadaveric-analysis
#1
Jonathan D Barlow, Ryan J McNeilan, Amy Speeckaert, Corey T Beals, Hisham M Awan
PURPOSE: No consensus has been reached on the most effective anatomic approach or fixation method for distal biceps repair. It is our hypothesis that, using a cortical biceps button through a 2-incision technique, the distal biceps can be safely and anatomically repaired. METHODS: A 2-incision biceps button distal biceps repair was completed on 10 fresh-frozen cadavers. The proximity of the guide pin to the critical structures of the forearm, including the posterior interosseous nerve and recurrent radial artery, was measured...
April 20, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28428600/water-fluoridation-there-is-no-evidence
#2
J F Beal, M Lennon
No abstract text is available yet for this article.
April 21, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28422998/reducing-dna-context-dependence-in-bacterial-promoters
#3
Swati B Carr, Jacob Beal, Douglas M Densmore
Variation in the DNA sequence upstream of bacterial promoters is known to affect the expression levels of the products they regulate, sometimes dramatically. While neutral synthetic insulator sequences have been found to buffer promoters from upstream DNA context, there are no established methods for designing effective insulator sequences with predictable effects on expression levels. We address this problem with Degenerate Insulation Screening (DIS), a novel method based on a randomized 36-nucleotide insulator library and a simple, high-throughput, flow-cytometry-based screen that randomly samples from a library of 436 potential insulated promoters...
2017: PloS One
https://www.readbyqxmd.com/read/28399168/global-trends-in-dietary-micronutrient-supplies-and-estimated-prevalence-of-inadequate-intakes
#4
Ty Beal, Eric Massiot, Joanne E Arsenault, Matthew R Smith, Robert J Hijmans
Understanding dietary patterns is vital to reducing the number of people experiencing hunger (about 795 million), micronutrient deficiencies (2 billion), and overweight or obesity (2.1 billion). We characterize global trends in dietary quality by estimating micronutrient density of the food supply, prevalence of inadequate intake of 14 micronutrients, and average prevalence of inadequate intake of these micronutrients for all countries between 1961 and 2011. Over this 50-year period, the estimated prevalence of inadequate intakes of micronutrients has declined in all regions due to increased total production of food and/or micronutrient density...
2017: PloS One
https://www.readbyqxmd.com/read/28397999/scalp-eeg-ictal-gamma-and-beta-activity-during-infantile-spasms-evidence-of-focality
#5
Hiroki Nariai, Jules Beal, Aristea S Galanopoulou, Wenzhu B Mowrey, Stephan Bickel, Yoshimi Sogawa, Rana Jehle, Shlomo Shinnar, Solomon L Moshé
OBJECTIVE: We investigated temporal and spatial characteristics of ictal gamma and beta activity on scalp EEG during spasms in patients with West syndrome (WS) to evaluate potential focal cortical onset. METHODS: A total of 1,033 spasms from 34 patients with WS of various etiologies were analyzed on video-electroencephalography (EEG) using time-frequency analysis. Ictal gamma (35-90 Hz) and beta (15-30 Hz) activities were correlated with visual symmetry of spasms, objective EMG (electromyography) analysis, and etiology of WS...
April 11, 2017: Epilepsia
https://www.readbyqxmd.com/read/28394459/ergogenic-properties-of-metformin-in-simulated-high-altitude
#6
Rebecca L Scalzo, Hunter L Paris, Scott E Binns, Janelle L Davis, Joseph W Beals, Christopher L Melby, Gary J Luckasen, Matthew S Hickey, Benjamin F Miller, Karyn L Hamilton, Christopher Bell
Metformin augments glucose/glycogen regulation and may acutely promote fatigue resistance during high-intensity exercise. In hypobaric environments, such as high altitude, the important contribution of carbohydrates to physiological function is accentuated as glucose/glycogen dependence is increased. Because hypoxia/hypobaria decreases insulin sensitivity, replenishing skeletal muscle glycogen in high altitude becomes challenging and subsequent physical performance may be compromised. We hypothesized that in conditions where glycogen repletion was critical to physical outcomes, metformin would attenuate hypoxia-mediated decrements in exercise performance...
April 10, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28390657/clinical-outcomes-of-patients-with-limited-brain-metastases-treated-with-hypofractionated-5%C3%A3-6gy-conformal-radiotherapy
#7
Natalie A Lockney, Diana G Wang, Philip H Gutin, Cameron Brennan, Viviane Tabar, Ase Ballangrud, Xin Pei, Timothy A Chan, Yoshiya Yamada, T Jonathan Yang, Kathryn Beal
BACKGROUND AND PURPOSE: Hypofractionated conformal radiotherapy (hfCRT) is used for larger brain metastases or metastases near critical structures. We investigated hfCRT outcomes for newly diagnosed brain metastases. MATERIALS AND METHODS: We identified 195 patients with 1-3 brain metastases who underwent 5×6Gy hfCRT for 231 lesions from 2007 to 2013. Associations among clinical factors, local control (LC), distant brain control (DC) and overall survival (OS) were tested using univariate and multivariate (MVA) Cox regression analysis and Kaplan-Meier method...
April 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28389798/total-robotic-pancreaticoduodenectomy-a-systematic-review-of-the-literature
#8
Michail Kornaropoulos, Demetrios Moris, Eliza W Beal, Marinos C Makris, Apostolos Mitrousias, Athanasios Petrou, Evangelos Felekouras, Adamantios Michalinos, Michail Vailas, Dimitrios Schizas, Alexandros Papalampros
BACKGROUND: Pancreaticoduodenectomy (PD) is a complex operation with high perioperative morbidity and mortality, even in the highest volume centers. Since the development of the robotic platform, the number of reports on robotic-assisted pancreatic surgery has been on the rise. This article reviews the current state of completely robotic PD. MATERIALS AND METHODS: A systematic literature search was performed including studies published between January 2000 and July 2016 reporting PDs in which all procedural steps (dissection, resection and reconstruction) were performed robotically...
April 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28380634/the-radiosurgery-fractionation-quandary-single-fraction-or-hypofractionation
#9
John P Kirkpatrick, Scott G Soltys, Simon S Lo, Kathryn Beal, Dennis C Shrieve, Paul D Brown
Stereotactic radiosurgery (SRS), typically administered in a single session, is widely employed to safely, efficiently, and effectively treat small intracranial lesions. However, for large lesions or those in close proximity to critical structures, it can be difficult to obtain an acceptable balance of tumor control while avoiding damage to normal tissue when single-fraction SRS is utilized. Treating a lesion in 2 to 5 fractions of SRS (termed "hypofractionated SRS" [HF-SRS]) potentially provides the ability to treat a lesion with a total dose of radiation that provides both adequate tumor control and acceptable toxicity...
April 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28372506/substitution-of-medical-cannabis-for-pharmaceutical-agents-for-pain-anxiety-and-sleep
#10
Brian J Piper, Rebecca M DeKeuster, Monica L Beals, Catherine M Cobb, Corey A Burchman, Leah Perkinson, Shayne T Lynn, Stephanie D Nichols, Alexander T Abess
A prior epidemiological study identified a reduction in opioid overdose deaths in US states that legalized medical cannabis (MC). One theory to explain this phenomenon is a potential substitution effect of MC for opioids. This study evaluated whether this substitution effect of MC for opioids also applies to other psychoactive medications. New England dispensary members ( n = 1,513) completed an online survey about their medical history and MC experiences. Among respondents that regularly used opioids, over three-quarters (76...
March 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28369783/utilization-of-sequence-variants-as-biomarkers-to-analyze-population-dynamics-in-cloned-cell-lines
#11
T Jennifer Lin, Kathryn M Beal, Heather S DeGruttola, Steven J Brennan, Lisa A Marzilli, Karin Anderson
The inherent nature of cloned CHO cell lines includes the presence of genetic and phenotypic drift that leads to heterogeneous populations. The genetic heterogeneity exhibited by these cells can be exploited to understand the population dynamics of cloned cell lines. Understanding the interplay between heterogeneity, cell culture conditions and population dynamics will allow for critical assessment of overarching cell line development methods and strategies in terms of population and monoclonality. Sequence variants (SVs) are protein isoforms of the gene-of-interest that contain unintended amino acid substitutions, extensions or truncations that may contribute to heterogeneity...
March 28, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28364930/improving-isc-performance-through-outsourcing-considerations-for-using-third-party-service-providers-to-increase-innovation-capacity-and-efficiency
#12
Martin Wright, Gary Forster, John Beale
Development partners and donors have encouraged and incentivized governments in developing countries to explore ways of working with third-party service suppliers to reduce costs and increase service delivery capacity. The distribution of vaccines and medicines has for a long time shown demand for outsourcing but public health systems have struggled to develop the expertise and capital assets necessary to manage such ventures. Existing transport and logistics capacity within public health systems, in particular, is well documented as being insufficient to support existing, let alone future immunization needs...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28364820/autoimmune-hepatitis-in-the-liver-transplant-graft
#13
REVIEW
Eliza W Beal, Sylvester M Black, Anthony Michaels
Recurrent autoimmune hepatitis (AIH) and de novo AIH are 2 important causes of late graft failure after liver transplantation (LT). Recurrent AIH occurs in patients who undergo LT for AIH. De novo AIH occurs in patients who are transplanted for etiologies other than AIH. Although typically treated with standard treatment for AIH, including corticosteroids and azathioprine, both recurrent and de novo AIH may progress to end-stage liver disease requiring retransplantation.
May 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28363889/hip-revision-arthroplasty-for-failed-osteosynthesis-in-periprosthetic-vancouver-type-b1-fractures-using-a-cementless-modular-tapered-revision-stem
#14
B Fink, D Oremek
AIMS: To evaluate the hypothesis that failed osteosynthesis of periprosthetic Vancouver type B1 fractures can be treated successfully with stem revision using a transfemoral approach and a cementless, modular, tapered revision stem with reproducible rates of fracture healing, stability of the revision stem, and clinically good results. PATIENTS AND METHODS: A total of 14 patients (11 women, three men) with a mean age of 72.4 years (65 to 90) undergoing revision hip arthroplasty after failed osteosynthesis of periprosthetic fractures of Vancouver type B1 were treated using a transfemoral approach to remove the well-fixed stem before insertion of a modular, fluted titanium stem which obtained distal fixation...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28353516/a-day-in-the-life-of-a-medicare-provider-outreach-education-manager
#15
Tramecya Monique Beale
No abstract text is available yet for this article.
April 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28345057/chemical-imaging-of-fischer-tropsch-catalysts-under-operating-conditions
#16
Stephen W T Price, David J Martin, Aaron D Parsons, Wojciech A Sławiński, Antonios Vamvakeros, Stephen J Keylock, Andrew M Beale, J Frederick W Mosselmans
Although we often understand empirically what constitutes an active catalyst, there is still much to be understood fundamentally about how catalytic performance is influenced by formulation. Catalysts are often designed to have a microstructure and nanostructure that can influence performance but that is rarely considered when correlating structure with function. Fischer-Tropsch synthesis (FTS) is a well-known and potentially sustainable technology for converting synthetic natural gas ("syngas": CO + H2) into functional hydrocarbons, such as sulfur- and aromatic-free fuel and high-value wax products...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28335448/a-community-multi-omics-approach-towards-the-assessment-of-surface-water-quality-in-an-urban-river-system
#17
David J Beale, Avinash V Karpe, Warish Ahmed, Stephen Cook, Paul D Morrison, Christopher Staley, Michael J Sadowsky, Enzo A Palombo
A multi-omics approach was applied to an urban river system (the Brisbane River (BR), Queensland, Australia) in order to investigate surface water quality and characterize the bacterial population with respect to water contaminants. To do this, bacterial metagenomic amplicon-sequencing using Illumina next-generation sequencing (NGS) of the V5-V6 hypervariable regions of the 16S rRNA gene and untargeted community metabolomics using gas chromatography coupled with mass spectrometry (GC-MS) were utilized. The multi-omics data, in combination with fecal indicator bacteria (FIB) counts, trace metal concentrations (by inductively coupled plasma mass spectrometry (ICP-MS)) and in-situ water quality measurements collected from various locations along the BR were then used to assess the health of the river ecosystem...
March 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28328576/chronic-pain-patients-perspectives-of-medical-cannabis
#18
Brian J Piper, Monica L Beals, Alexander T Abess, Stephanie D Nichols, Maurice W Martin, Catherine M Cobb, Rebecca M DeKeuster
Medical cannabis (MC) is used for a variety of conditions including chronic pain. The goal of this report was to provide an in-depth qualitative exploration of patient perspectives on the strengths and limitations of MC. Members of MC dispensaries (N = 984) in New England including two-thirds with a history of chronic pain completed an online survey. In response to "How effective is medical cannabis in treating your symptoms or conditions?," with options of 0% "no relief" to 100% "complete relief," the average was 74...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28319614/biophysics-a-toehold-in-cell-surface-dynamics
#19
Paul A Beales
No abstract text is available yet for this article.
March 20, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28316007/talimogene-laherparepvec-for-treating-metastatic-melanoma-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#20
REVIEW
Nigel Fleeman, Adrian Bagust, Angela Boland, Sophie Beale, Marty Richardson, Ashma Krishan, Angela Stainthorpe, Ahmed Abdulla, Eleanor Kotas, Lindsay Banks, Miranda Payne
The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Amgen) of talimogene laherparepvec (T-VEC) to submit clinical and cost-effectiveness evidence for previously untreated advanced (unresectable or metastatic) melanoma as part of the Institute's Single Technology Appraisal process. The Liverpool Reviews and Implementation Group (LRiG) at the University of Liverpool was commissioned to act as the Evidence Review Group (ERG). This article presents a summary of the company's submission of T-VEC, the ERG review and the resulting NICE guidance (TA410), issued in September 2016...
March 18, 2017: PharmacoEconomics
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