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Blood brain barrier and liposomes

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https://www.readbyqxmd.com/read/29210401/hybrid-magneto-plasmonic-liposomes-for-multimodal-image-guided-and-brain-targeted-hiv-treatment
#1
Asahi Tomitaka, Hamed Arami, Zaohua Huang, Andrea Raymond, Elizette Rodriguez, Yong Cai, Marcelo Febo, Yasushi Takemura, Madhavan Nair
Image-guided drug delivery is an emerging strategy in the field of nanomedicine. The addition of image guidance to a traditional drug delivery system is expected to achieve highly efficient treatment by tracking the drug carriers in the body and monitoring their effective accumulation in the targeted tissues. In this study, we developed multifunctional magneto-plasmonic liposomes (MPLs), a hybrid system combining liposomes and magneto-plasmonic nanoparticles for a triple-modality image-guided drug delivery...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29189138/intranasal-lipid-nanoparticles-for-the-treatment-of-neurodegenerative-diseases
#2
S Cunha, H Almeida, M H Amaral, J M Sousa Lobo, A C Silva
BACKGROUND: Current treatments for neurodegenerative diseases are challenging, due to the absence of full effective medicines. One of the major problems associated to these is the occurrence of non-targeting events, which leads to adverse effects and requires frequent dose administration. METHODS: Researches have been performed to develop new drug delivery systems administrated by alternative routes. For example, the direct nose-to-brain delivery of drugs by means of lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), have been showing promising results...
November 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29166813/the-efficacy-of-rgd-modified-liposomes-loaded-with-vinorelbine-plus-tetrandrine-in-treating-resistant-brain-glioma
#3
Xue-Tao Li, Wei Tang, Hong-Jun Xie, Shuang Liu, Xiao-Li Song, Yao Xiao, Xin Wang, Lan Cheng, Gui-Rong Chen
Brain glioma is one of the most common and devastating intracranial malignancies with a high mortality. Chemotherapy for brain glioma is not ideal due to blood brain barrier (BBB) and multidrug resistance (MDR). The objectives of the present study were to develop a kind of RGD (Arg-Gly-Asp) tripeptide modified vinorelbine plus tetrandrine liposomes to achieve BBB transportation, MDR reversion and glioma cell targeting simultaneously. The studies were performed on glioma cells, resistant glioma cells and glioma-bearing mice...
November 22, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29163138/perspective-insights-into-disease-progression-diagnostics-and-therapeutic-approaches-in-alzheimer-s-disease-a-judicious-update
#4
REVIEW
Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M S Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Choi
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons. Representing a common form of dementia, aggravation of AD with age increases the morbidity rate among the elderly. Although, mutations in the ApoE4 act as potent risk factors for sporadic AD, familial AD arises through malfunctioning of APP, PSEN-1, and-2 genes. AD progresses through accumulation of amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) in brain, which interfere with neuronal communication...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29162480/dual-targeting-immunoliposomes-using-angiopep-2-and-cd133-antibody-for-glioblastoma-stem-cells
#5
Jung Seok Kim, Dae Hwan Shin, Jin-Seok Kim
Glioblastoma stem cells (GSCs), which are identified as subpopulation of CD133(+)/ALDH1(+), are known to show resistance to the most of chemotherapy and radiation therapy, leading to the recurrence of tumor in glioblastoma multiforme (GBM) patients. Also, delivery of temozolomide (TMZ), a mainline treatment of GBM, to the GBM site is hampered by various barriers including the blood-brain barrier (BBB). A dual-targeting immunoliposome encapsulating TMZ (Dual-LP-TMZ) was developed by using angiopep-2 (An2) and anti-CD133 monoclonal antibody (CD133 mAb) for BBB transcytosis and specific delivery to GSCs, respectively...
November 18, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29161215/recent-advances-in-nanomedicine-and-survivin-targeting-in-brain-cancers
#6
Jake Mazur, Kislay Roy, Jagat R Kanwar
Brain cancer is a highly lethal disease, especially devastating toward both the elderly and children. This cancer has no therapeutics available to combat it, predominately due to the blood-brain barrier (BBB) preventing treatments from maintaining therapeutic levels within the brain. Recently, nanoparticle technology has entered the forefront of cancer therapy due to its ability to deliver therapeutic effects while potentially passing physiological barriers. Key nanoparticles for brain cancer treatment include glutathione targeted PEGylated liposomes, gold nanoparticles, superparamagnetic iron oxide nanoparticles and nanoparticle-albumin bound drugs, with these being discussed throughout this review...
November 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29133392/closed-loop-control-of-targeted-ultrasound-drug-delivery-across-the-blood-brain-tumor-barriers-in-a-rat-glioma-model
#7
Tao Sun, Yongzhi Zhang, Chanikarn Power, Phillip M Alexander, Jonathan T Sutton, Muna Aryal, Natalia Vykhodtseva, Eric L Miller, Nathan J McDannold
Cavitation-facilitated microbubble-mediated focused ultrasound therapy is a promising method of drug delivery across the blood-brain barrier (BBB) for treating many neurological disorders. Unlike ultrasound thermal therapies, during which magnetic resonance thermometry can serve as a reliable treatment control modality, real-time control of modulated BBB disruption with undetectable vascular damage remains a challenge. Here a closed-loop cavitation controlling paradigm that sustains stable cavitation while suppressing inertial cavitation behavior was designed and validated using a dual-transducer system operating at the clinically relevant ultrasound frequency of 274...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29128836/characterization-of-liposome-containing-spions-conjugated-with-anti-cd20-developed-as-a-novel-theranostic-agent-for-central-nervous-system-lymphoma
#8
S Saesoo, S Sathornsumetee, P Anekwiang, C Treetidnipa, P Thuwajit, S Bunthot, W Maneeprakorn, L Maurizi, H Hofmann, Ruktanonchai Uracha Rungsardthong, N Saengkrit
Despite advances in neuroscience cancer research during the past decades, the survival of cancer patients has only marginally improved and the cure remains unlikely. The blood-brain barrier (BBB) is a major obstacle protecting the entry of therapeutic agents to central nervous system, especially for primary central nervous system lymphoma (PCNSL). Thus, the use of small nanoparticle as a drug carrier may be new strategies to overcome this problem. In this study, we fabricated liposome consisting of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with anti-CD20 (Rituximab; RTX)...
November 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29046146/phospholipid-based-immobilized-artificial-membrane-iam-chromatography-a-powerful-tool-to-model-drug-distribution-processes
#9
Anna W Sobańska, Elżbieta Brzezińska
A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented...
October 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28993773/targeting-malignant-brain-tumors-with-antibodies
#10
REVIEW
Rok Razpotnik, Neža Novak, Vladka Čurin Šerbec, Uros Rajcevic
Antibodies have been shown to be a potent therapeutic tool. However, their use for targeting brain diseases, including neurodegenerative diseases and brain cancers, has been limited, particularly because the blood-brain barrier (BBB) makes brain tissue hard to access by conventional antibody-targeting strategies. In this review, we summarize new antibody therapeutic approaches to target brain tumors, especially malignant gliomas, as well as their potential drawbacks. Many different brain delivery platforms for antibodies have been studied such as liposomes, nanoparticle-based systems, cell-penetrating peptides (CPPs), and cell-based approaches...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28988704/fungal-infections-of-the-central-nervous-system-in-small-animals-clinical-features-diagnosis-and-management
#11
REVIEW
R Timothy Bentley, Amanda R Taylor, Stephanie A Thomovsky
Small animal mycoses vary geographically. Different clinical presentations are seen in animals with infection of the central nervous system (CNS), including multifocal meningoencephalomyelitis, intracranial lesions that accompany sinonasal lesions, rapidly progressive ventriculitis, or solitary granuloma of the brain or spinal cord. Systemic, nasal, or extraneural clinical signs are common but, especially in granuloma cases, do not always occur. Surgery may have a diagnostic and therapeutic role in CNS granuloma...
October 5, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28978003/multifunctional-targeted-liposomal-drug-delivery-for-efficient-glioblastoma-treatment
#12
Zakia Belhadj, Changyou Zhan, Man Ying, Xiaoli Wei, Cao Xie, Zhiqiang Yan, Weiyue Lu
Glioblastoma multiforme (GBM) has been considered to be the most malignant brain tumors. Due to the existence of various barriers including the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) greatly hinder the accumulation and deep penetration of chemotherapeutics, the treatment of glioma remains to be the most challenging task in clinic. In order to circumvent these hurdles, we developed a multifunctional liposomal glioma-targeted drug delivery system (c(RGDyK)/pHA-LS) modified with cyclic RGD (c(RGDyK)) and p-hydroxybenzoic acid (pHA) in which c(RGDyK) could target integrin αvβ3 overexpressed on the BBTB and glioma cells and pHA could target dopamine receptors on the BBB...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976512/enhanced-blood-brain-barrier-permeability-and-glioblastoma-cell-targeting-via-thermoresponsive-lipid-nanoparticles
#13
M Rehman, A Madni, D Shi, A Ihsan, N Tahir, K R Chang, I Javed, T J Webster
Thermoresponsive targeting is used to deliver therapeutic agents at hyperthermic conditions (39-45 °C). However, available thermoresponsive drug delivery systems (TDDS), including liposomes, have a complex method of preparation involving toxic solvents and reagents. The objective of this in vitro study was to prepare and characterize thermoresponsive lipid nanoparticles (TLN) for treating glioblastoma, the most aggressive brain tumor whose treatment is limited by a low blood brain barrier (BBB) permeability of drugs...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28969057/the-construction-of-the-multifunctional-targeting-ursolic-acids-liposomes-and-its-apoptosis-effects-to-c6-glioma-stem-cells
#14
Xue Ying, Yahua Wang, Haolun Xu, Xia Li, Helu Yan, Hui Tang, Chen Wen, Yingchun Li
Brain gliomas, one of the most fatal tumors to human, severely threat the health and life of human. They are capable of extremely strong invasion ability. And invasive glioma cells could rapidly penetrate into normal brain tissues and break them. We prepared a kind of functional liposomes, which could be transported acrossing the blood-brain barrier (BBB) and afterwards induce the apoptosis of glioma stem cells. In this research, we chose ursolic acids (UA) as an anti-cancer drug to inhibit the growth of C6 glioma cells, while epigallocatechin 3-gallate(EGCG) as the agent that could induce the apoptosis of C6 glioma stem cells...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28958145/large-amino-acid-transporter-1-selective-liposomes-of-l-dopa-functionalized-amphiphile-for-combating-glioblastoma
#15
Sukanya Bhunia, Venugopal Vangala, Dwaipayan Bhattacharya, Halley Gora Ravuri, Madhusudana Kuncha, Sumana Chakravarty, Ramakrishna Sistla, Arabinda Chaudhuri
Despite significant progress in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. The scope of systemic chemotherapy is greatly limited by poor drug transport across the blood brain barrier (BBB) and, thereby, suboptimal drug accumulation in glioma tissue. To this end, use of large amino acid transporter-1 (LAT1) overexpressed both on brain capillary endothelial cells (BCECs) and glioma cells has begun. Prior reports on the use of LAT1 mediated delivery of model drugs showed their brain accumulations...
November 6, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28887220/enhanced-glioma-therapy-by-synergistic-inhibition-of-autophagy-and-tyrosine-kinase-activity
#16
Xuhui Wang, Yue Qiu, Qianwen Yu, Hui Li, Xiaoxiao Chen, Man Li, Yang Long, Yayuan Liu, Libao Lu, Jiajing Tang, Zhirong Zhang, Qin He
Autophagy is a lysosomal degradation pathway that acts as a cytoprotective mechanism causing treatment resistance in various cancer cells. Recent studies showed that hydroxychloroquine can inhibit the latter step of autophagy and therefore enhance the anti-glioma efficiency of ZD6474, a tyrosine kinase inhibitor. However, the nonselective distribution of ZD6474 in vivo and the low penetrating ability of hydroxychloroquine when crossing the blood-brain barrier restrict their clinical use in glioma therapy. Here we coencapsulated ZD6474 and hydroxychloroquine into R6dGR peptide-modified liposomes (R6dGR-Lip) which can specifically recognize both integrin αvβ3 and neuropilin-1 receptors that are highly expressed on the endothelial cells and glioma cells...
September 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28887135/progress-in-brain-targeting-drug-delivery-system-by-nasal-route
#17
REVIEW
Abdur Rauf Khan, Mengrui Liu, Muhammad Wasim Khan, Guangxi Zhai
The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the BBB has gained an important consideration for delivery of wide range of therapeutics to brain. Intranasal route of transportation directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route...
September 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#18
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
October 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28756093/noninvasive-nanoparticle-strategies-for-brain-tumor-targeting
#19
REVIEW
Chunmeng Sun, Yang Ding, Li Zhou, Di Shi, Linlin Sun, Thomas J Webster, Yan Shen
The blood-brain barrier (BBB) maintains the integrity and homeostasis of the central nervous system (CNS) yet represents an intimidating hurdle for efficient drug delivery to brain tumors. This up-to-date review summarizes strategies that have been employed to cross the BBB with a focus on non-invasive nanoparticles that could pass the BBB after systemic administration. Recent advances in liposomes, polymeric nanoparticles, micelles, and inorganic nanoparticles are scrutinized mechanistically with an emphasis on design principles...
July 27, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28699828/glioma-targeted-delivery-strategy-of-doxorubicin-loaded-liposomes-by-dual-ligand-modification
#20
Wei Han, Guangfu Yin, Ximing Pu, Xianchun Chen, Xiaoming Liao, Zhongbing Huang
The blood-brain barrier (BBB) is the protective parclose of brain safety, but it is also the main obstacle of the drug delivery to cerebral parenchyma, which hamper therapy for brain diseases. In this work, a glioma targeted drug delivery system was developed through loading doxorubicin into Angiopep-2 and TAT peptide dual-modified liposomes (DOX-TAT-Ang-LIP). Low-density lipoprotein receptor-related protein-1 (LRP1) was one receptor overexpressed on both BBB and glioma cytomembranes. Angiopep-2, a specific ligand of LRP1, exhibited high LRP1 binding efficiency...
July 12, 2017: Journal of Biomaterials Science. Polymer Edition
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