keyword
MENU ▼
Read by QxMD icon Read
search

Blood brain barrier and liposomes

keyword
https://www.readbyqxmd.com/read/28993773/targeting-malignant-brain-tumors-with-antibodies
#1
REVIEW
Rok Razpotnik, Neža Novak, Vladka Čurin Šerbec, Uros Rajcevic
Antibodies have been shown to be a potent therapeutic tool. However, their use for targeting brain diseases, including neurodegenerative diseases and brain cancers, has been limited, particularly because the blood-brain barrier (BBB) makes brain tissue hard to access by conventional antibody-targeting strategies. In this review, we summarize new antibody therapeutic approaches to target brain tumors, especially malignant gliomas, as well as their potential drawbacks. Many different brain delivery platforms for antibodies have been studied such as liposomes, nanoparticle-based systems, cell-penetrating peptides (CPPs), and cell-based approaches...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28988704/fungal-infections-of-the-central-nervous-system-in-small-animals-clinical-features-diagnosis-and-management
#2
REVIEW
R Timothy Bentley, Amanda R Taylor, Stephanie A Thomovsky
Small animal mycoses vary geographically. Different clinical presentations are seen in animals with infection of the central nervous system (CNS), including multifocal meningoencephalomyelitis, intracranial lesions that accompany sinonasal lesions, rapidly progressive ventriculitis, or solitary granuloma of the brain or spinal cord. Systemic, nasal, or extraneural clinical signs are common but, especially in granuloma cases, do not always occur. Surgery may have a diagnostic and therapeutic role in CNS granuloma...
October 5, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28978003/multifunctional-targeted-liposomal-drug-delivery-for-efficient-glioblastoma-treatment
#3
Zakia Belhadj, Changyou Zhan, Man Ying, Xiaoli Wei, Cao Xie, Zhiqiang Yan, Weiyue Lu
Glioblastoma multiforme (GBM) has been considered to be the most malignant brain tumors. Due to the existence of various barriers including the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) greatly hinder the accumulation and deep penetration of chemotherapeutics, the treatment of glioma remains to be the most challenging task in clinic. In order to circumvent these hurdles, we developed a multifunctional liposomal glioma-targeted drug delivery system (c(RGDyK)/pHA-LS) modified with cyclic RGD (c(RGDyK)) and p-hydroxybenzoic acid (pHA) in which c(RGDyK) could target integrin αvβ3 overexpressed on the BBTB and glioma cells and pHA could target dopamine receptors on the BBB...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976512/enhanced-blood-brain-barrier-permeability-and-glioblastoma-cell-targeting-via-thermoresponsive-lipid-nanoparticles
#4
M Rehman, A Madni, D Shi, A Ihsan, N Tahir, K R Chang, I Javed, T J Webster
Thermoresponsive targeting is used to deliver therapeutic agents at hyperthermic conditions (39-45 °C). However, available thermoresponsive drug delivery systems (TDDS), including liposomes, have a complex method of preparation involving toxic solvents and reagents. The objective of this in vitro study was to prepare and characterize thermoresponsive lipid nanoparticles (TLN) for treating glioblastoma, the most aggressive brain tumor whose treatment is limited by a low blood brain barrier (BBB) permeability of drugs...
October 4, 2017: Nanoscale
https://www.readbyqxmd.com/read/28969057/the-construction-of-the-multifunctional-targeting-ursolic-acids-liposomes-and-its-apoptosis-effects-to-c6-glioma-stem-cells
#5
Xue Ying, Yahua Wang, Haolun Xu, Xia Li, Helu Yan, Hui Tang, Chen Wen, Yingchun Li
Brain gliomas, one of the most fatal tumors to human, severely threat the health and life of human. They are capable of extremely strong invasion ability. And invasive glioma cells could rapidly penetrate into normal brain tissues and break them. We prepared a kind of functional liposomes, which could be transported acrossing the blood-brain barrier (BBB) and afterwards induce the apoptosis of glioma stem cells. In this research, we chose ursolic acids (UA) as an anti-cancer drug to inhibit the growth of C6 glioma cells, while epigallocatechin 3-gallate(EGCG) as the agent that could induce the apoptosis of C6 glioma stem cells...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28958145/large-aminoacid-transporter-1-selective-liposomes-of-l-dopa-functionalized-amphiphile-for-combating-glioblastoma
#6
Sukanya Bhunia, Venugopal Vangala, Dwaipayan Bhattacharya, Halley Gora Ravuri, Madhusudana Kuncha, Sumana Chakravarty, Ramakrishna Sistla, Arabinda Chaudhuri
Despite significant progresses in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. Scope of systemic chemotherapy is greatly limited by poor drug transport across blood brain barrier (BBB), and thereby, sub-optimal drug accumulation in glioma tissue. To this end, use of large amino acid transporter-1 (LAT1) over expressed both on brain capillary endothelial cells (BCECs) and glioma cells have begun. Prior reports on the use of LAT1 mediated delivery of model drugs showed their brain accumulations...
September 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28887220/enhanced-glioma-therapy-by-synergistic-inhibition-of-autophagy-and-tyrosine-kinase-activity
#7
Xuhui Wang, Yue Qiu, Qianwen Yu, Hui Li, Xiaoxiao Chen, Man Li, Yang Long, Yayuan Liu, Libao Lu, Jiajing Tang, Zhirong Zhang, Qin He
Autophagy is a lysosomal degradation pathway that acts as a cytoprotective mechanism causing treatment resistance in various cancer cells. Recent studies showed that hydroxychloroquine can inhibit the latter step of autophagy and therefore enhance the anti-glioma efficiency of ZD6474, a tyrosine kinase inhibitor. However, the nonselective distribution of ZD6474 in vivo and the low penetrating ability of hydroxychloroquine when crossing the blood-brain barrier restrict their clinical use in glioma therapy. Here we coencapsulated ZD6474 and hydroxychloroquine into R6dGR peptide-modified liposomes (R6dGR-Lip) which can specifically recognize both integrin αvβ3 and neuropilin-1 receptors that are highly expressed on the endothelial cells and glioma cells...
September 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28887135/progress-in-brain-targeting-drug-delivery-system-by-nasal-route
#8
REVIEW
Abdur Rauf Khan, Mengrui Liu, Muhammad Wasim Khan, Guangxi Zhai
The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the BBB has gained an important consideration for delivery of wide range of therapeutics to brain. Intranasal route of transportation directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route...
September 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#9
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28756093/noninvasive-nanoparticle-strategies-for-brain-tumor-targeting
#10
REVIEW
Chunmeng Sun, Yang Ding, Li Zhou, Di Shi, Linlin Sun, Thomas J Webster, Yan Shen
The blood-brain barrier (BBB) maintains the integrity and homeostasis of the central nervous system (CNS) yet represents an intimidating hurdle for efficient drug delivery to brain tumors. This up-to-date review summarizes strategies that have been employed to cross the BBB with a focus on non-invasive nanoparticles that could pass the BBB after systemic administration. Recent advances in liposomes, polymeric nanoparticles, micelles, and inorganic nanoparticles are scrutinized mechanistically with an emphasis on design principles...
July 27, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28699828/glioma-targeted-delivery-strategy-of-doxorubicin-loaded-liposomes-by-dual-ligand-modification
#11
Wei Han, Guangfu Yin, Ximing Pu, Xianchun Chen, Xiaoming Liao, Zhongbing Huang
The blood-brain barrier (BBB) is the protective parclose of brain safety, but it is also the main obstacle of the drug delivery to cerebral parenchyma, which hamper therapy for brain diseases. In this work, a glioma targeted drug delivery system was developed through loading doxorubicin into Angiopep-2 and TAT peptide dual-modified liposomes (DOX-TAT-Ang-LIP). Low-density lipoprotein receptor-related protein-1 (LRP1) was one receptor overexpressed on both BBB and glioma cytomembranes. Angiopep-2, a specific ligand of LRP1, exhibited high LRP1 binding efficiency...
July 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28687044/dual-modified-liposome-codelivery-of-doxorubicin-and-vincristine-improve-targeting-and-therapeutic-efficacy-of-glioma
#12
Yue Zhang, Meifang Zhai, Zhijiang Chen, Xiaoyang Han, Fanglin Yu, Zhiping Li, Xiangyang Xie, Cuiyan Han, Lian Yu, Yang Yang, Xingguo Mei
Therapeutic outcome for the treatment of glioma was often limited due to drug resistance and low permeability of drug across the multiple physiological barriers, including the blood-brain barrier (BBB), and the blood-tumor barrier (BTB). In order to overcome these hurdles, we designed T7 and (D)A7R dual peptides-modified liposomes (abbreviated as T7/(D)A7R-LS) to efficiently co-delivery doxorubicin (DOX) and vincristine (VCR) to glioma in this study. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28619756/alpha-particle-enhanced-blood-brain-tumor-barrier-permeabilization-in-glioblastomas-using-integrin-alpha-v-beta-3-targeted-liposomes
#13
Anirudh Sattiraju, Xiaobing Xiong, Darpan N Pandya, Thaddeus J Wadas, Ang Xuan, Yao Sun, Youngkyoo Jung, Kiran Kumar Solingapuram Sai, Jay F Dorsey, King C Li, Akiva Mintz
Glioblastoma (GBM) is the most common primary malignant astrocytoma characterized by extensive invasion, angiogenesis, hypoxia, and micrometastasis. Despite the relatively leaky nature of GBM blood vessels, effective delivery of antitumor therapeutics has been a major challenge due to the complications caused by the blood-brain barrier (BBB) and the highly torturous nature of newly formed tumor vasculature (blood tumor barrier-BTB). External beam radiotherapy was previously shown to be an effective means of permeabilizing central nervous system (CNS) barriers...
October 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28615716/lipid-vesicles-containing-transferrin-receptor-binding-peptide-tfr-t12-and-octa-arginine-conjugate-stearyl-r8-efficiently-treat-brain-glioma-along-with-glioma-stem-cells
#14
Li-Min Mu, Ying-Zi Bu, Lei Liu, Hong-Jun Xie, Rui-Jun Ju, Jia-Shuan Wu, Fan Zeng, Yao Zhao, Jing-Ying Zhang, Wan-Liang Lu
Surgery and radiotherapy cannot fully remove brain glioma; thus, chemotherapy continues to play an important role in treatment of this illness. However, because of the restriction of the blood-brain barrier (BBB) and the regeneration of glioma stem cells, post-chemotherapy relapse usually occurs. Here, we report a potential solution to these issues that involves a type of novel multifunctional vinblastine liposomes equipped with transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28591726/multifunctional-targeted-liposomal-drug-delivery-for-efficient-glioblastoma-treatment
#15
Zakia Belhadj, Changyou Zhan, Man Ying, Xiaoli Wei, Cao Xie, Zhiqiang Yan, Weiyue Lu
Glioblastoma multiforme (GBM) has been considered to be the most malignant brain tumors. Due to the existence of various barriers including the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) greatly hinder the accumulation and deep penetration of chemotherapeutics, the treatment of glioma remains to be the most challenging task in clinic. In order to circumvent these hurdles, we developed a multifunctional liposomal glioma-targeted drug delivery system (c(RGDyK)/pHA-LS) modified with cyclic RGD (c(RGDyK)) and p-hydroxybenzoic acid (pHA) in which c(RGDyK) could target integrin αvβ3 overexpressed on the BBTB and glioma cells and pHA could target dopamine receptors on the BBB...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28583810/antitumor-efficacy-of-lf-modified-daunorubicin-plus-honokiol-liposomes-in-treatment-of-brain-glioma
#16
Shuang Liu, Shi-Meng Zhang, Rui-Jun Ju, Yao Xiao, Xin Wang, Xiao-Li Song, Li-Yan Gu, Lan Cheng, Xue-Tao Li, Gui-Rong Chen
Malignant brain glioma is the most common and aggressive type of primary intracranial neoplasm. Regular chemotherapy cannot eradicate brain glioma cells and the residual glioma cells could form vasculogenic mimicry (VM) channels under hypoxic conditions to provide nutrients for tumor cell invasion. In addition, the existence of the blood-brain barrier (BBB) restricts most antitumor drugs into brain glioma. In this study, we developed a kind of lactoferrin (Lf) modified daunorubicin plus honokiol liposomes to transport antitumor drugs across BBB, eliminate the VM channels and block tumor cell invasion...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28578696/nasal-delivery-of-nanoliposome-encapsulated-ferric-ammonium-citrate-can-increase-the-iron-content-of-rat-brain
#17
Xueling Guo, Hong Zheng, Yuetong Guo, Yan Wang, Gregory J Anderson, Yunzhe Ci, Peng Yu, Lina Geng, Yan-Zhong Chang
BACKGROUND: Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow efficient iron delivery to the brain due to the presence of the blood-brain barrier. So an easily delivered iron formulation with high absorption efficiency potentially could find widespread application in iron deficient infants. RESULTS: In this study, we have developed and characterized a nanovesicular formulation of ferric ammonium citrate (ferric ammonium citrate nanoliposomes, FAC-LIP) and have shown that it can increase brain iron levels in rats following nasal administration...
June 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28577913/anticonvulsant-activity-of-resveratrol-loaded-liposomes-in-vivo
#18
M S Ethemoglu, F B Seker, H Akkaya, E Kilic, I Aslan, C S Erdogan, B Yilmaz
Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and chemopreventive, yet, there is limited information about its antiepileptic effects. Moreover, its poor solubility in water and low bioavailability are the challenging issues. In the present study, we aimed to investigate effects of free resveratrol and resveratrol delivered in amphipathic liposomal delivery system, which has a high blood-brain barrier crossing potential, on penicillin-induced epileptic seizure model...
June 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28558193/influence-of-size-and-shape-on-the-anatomical-distribution-of-endotoxin-free-gold-nanoparticles
#19
Laura Talamini, Martina B Violatto, Qi Cai, Marco P Monopoli, Karsten Kantner, Željka Krpetić, André Perez-Potti, Jennifer Cookman, David Garry, Camila P Silveira, Luca Boselli, Beatriz Pelaz, Tommaso Serchi, Sébastien Cambier, Arno C Gutleb, Neus Feliu, Yan Yan, Mario Salmona, Wolfgang J Parak, Kenneth A Dawson, Paolo Bigini
The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology. Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized. Although it is widely known that elementary properties of nanomaterials influence their in vivo kinetics, such interaction is often poorly investigated in many preclinical studies. The present study aims to evaluate the actual effect of size and shape on the biodistribution of a set of gold nanoparticles (GNPs) after intravenous administration in mice...
June 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28552267/recent-advances-in-ultrasound-based-diagnosis-and-therapy-with-micro-and-nanometer-sized-formulations
#20
REVIEW
Nihan Güvener, Lia Appold, Federica de Lorenzi, Susanne K Golombek, Larissa Y Rizzo, Twan Lammers, Fabian Kiessling
Ultrasound (US) is one of the most frequently used imaging methods in the clinic. The broad spectrum of its applications can be increased by the use of gas-filled microbubbles (MB) as ultrasound contrast agents (UCA). In recent years, also nanoscale UCA like nanobubbles (NB), echogenic liposomes (ELIP) and nanodroplets have been developed, which in contrast to MB, are able to extravasate from the vessels into the tissue. New disease-specific UCA have been designed for the assessment of tissue biomarkers and advanced US to a molecular imaging modality...
May 24, 2017: Methods: a Companion to Methods in Enzymology
keyword
keyword
106836
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"