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Blood brain barrier and liposomes

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https://www.readbyqxmd.com/read/29800759/synergistic-tumor-microenvironment-targeting-and-blood-brain-barrier-penetration-via-a-ph-responsive-dual-ligand-strategy-for-enhanced-breast-cancer-and-brain-metastasis-therapy
#1
Man Li, Kairong Shi, Xian Tang, Jiaojie Wei, Xingli Cun, Yang Long, Zhirong Zhang, Qin He
Cancer associated fibroblasts (CAFs) which shape the tumor microenvironment (TME) and the presence of blood brain barrier (BBB) remain great challenges in targeting breast cancer and its brain metastasis. Herein, we reported a strategy using PTX-loaded liposome co-modified with acid-cleavable folic acid (FA) and BBB transmigrating cell penetrating peptide dNP2 peptide (cFd-Lip/PTX) for enhanced delivery to orthotopic breast cancer and its brain metastasis. Compared with single ligand or non-cleavable Fd modified liposomes, cFd-Lip exhibited synergistic TME targeting and BBB transmigration...
May 22, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29790744/myristic-acid-modified-da7r-peptide-for-whole-process-glioma-targeted-drug-delivery
#2
Man Ying, Songli Wang, Mingfei Zhang, Ruifeng Wang, Hangchang Zhu, Huitong Ruan, Danni Ran, Zhilan Chai, Xiaoyi Wang, Weiyue Lu
Clinical treatment of aggressive glioma has been a great challenge, mainly due to the complexity of glioma microenvironment and the existence of blood-brain tumor barrier (BBTB)/blood-brain barrier (BBB), which severely hamper the effective accumulation of most therapeutic agents in glioma region. Additionally, vasculogenic mimicry (VM), angiogenesis and glioma stem cells (GSC) in malignant glioma also lead to the failure of clinical therapy. To address the aforementioned issues, a whole-process glioma targeted drug delivery strategy was proposed...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29721078/localized-delivery-of-curcumin-into-brain-with-polysorbate-80-modified-cerasomes-by-ultrasound-targeted-microbubble-destruction-for-improved-parkinson-s-disease-therapy
#3
Nisi Zhang, Fei Yan, Xiaolong Liang, Manxiang Wu, Yuanyuan Shen, Min Chen, Yunxue Xu, Guangyang Zou, Peng Jiang, Caiyun Tang, Hairong Zheng, Zhifei Dai
Rationale: Treatment for Parkinson's disease (PD) is challenged by the presence of the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a patient's brain for therapeutic response throughout various stages of PD. Curcumin holds the potential for α-synuclein clearance to treat PD; however, its applications are still limited due to its low bioavailability and poor permeability through the BBB in a free form. Methods: Herein, this paper fabricated curcumin-loaded polysorbate 80-modified cerasome (CPC) nanoparticles (NPs) with a mean diameter of ~110 nm for enhancing the localized curcumin delivery into the targeted brain nuclei via effective BBB opening in combination with ultrasound-targeted microbubble destruction (UTMD)...
2018: Theranostics
https://www.readbyqxmd.com/read/29719787/liposomes-and-lipid-disks-traverse-the-bbb-and-bbtb-as-intact-forms-as-revealed-by-two-step-f%C3%A3-rster-resonance-energy-transfer-imaging
#4
Tongcheng Dai, Kuan Jiang, Weiyue Lu
The blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB) prevent drug and nano-drug delivery systems from entering the brain. However, ligand-mediated nano-drug delivery systems have significantly enhanced the therapeutic treatment of glioma. In this study we investigated the mechanism especially the integrity of liposomes and lipid disks while traversing the BBB and BBTB both in vitro and in vivo . Fluorophores (DiO, DiI and DiD) were loaded into liposomes and lipid disks to form Förster resonance energy transfer (FRET) nano-drug delivery systems...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29704642/verapamil-and-riluzole-cocktail-liposomes-overcome-pharmacoresistance-by-inhibiting-p-glycoprotein-in-brain-endothelial-and-astrocyte-cells-a-potent-approach-to-treat-amyotrophic-lateral-sclerosis
#5
Tianzhi Yang, Laine Ferrill, Leanne Gallant, Sarah McGillicuddy, Tatiana Fernandes, Nicole Schields, Shuhua Bai
Riluzole is currently one of two approved medications for the treatment of amyotrophic lateral sclerosis (ALS). However, brain disposition of riluzole, as a substrate of P-glycoprotein (P-gp), is limited by the efflux transporters at the blood-brain barrier (BBB). We propose to develop a liposomal co-delivery system that could effectively transport riluzole to brain cells by reducing efflux pumps with a P-gp inhibitor, verapamil. Riluzole and verapamil cocktail liposomes were prepared by lipid film hydration...
July 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29694498/production-characterization-and-toxicology-assay-of-creatine-pegylated-nanoliposome-with-polysorbate-80-for-brain-delivery
#6
Diego B Borin, Nathana J Mezzomo, Rodrigo A Vaucher, Guilherme DO Carmo, Luiz C Rodrigues Junior, Fernando B Sulczewski, Claiton I Schwertz, Ricardo E Mendes, Adriani P Damiani, Vanessa M DE Andrade, Virgínia C Rech, Carina R Boeck
Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nanoliposomes were produced, characterized and assayed in models of toxicity in vitro and in vivo. Particles showed negative zeta potential (-12,5 mV), polydispersity index 0...
April 23, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29688083/localized-delivery-of-therapeutic-doxorubicin-dose-across-the-canine-blood-brain-barrier-with-hyperthermia-and-temperature-sensitive-liposomes
#7
Amy Lee Bredlau, Anjan Motamarry, Chao Chen, M A McCrackin, Kris Helke, Kent E Armeson, Katrina Bynum, Ann-Marie Broome, Dieter Haemmerich
Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transiently opens the BBB, we hypothesized that localized hyperthermia can achieve drug delivery across the BBB when combined with TSL. TSL-encapsulated doxorubicin (TSL-Dox) was infused intravenously over 30 min at a dose of 0...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29655691/functionalized-liposomes-and-phytosomes-loading-annona-muricata-l-aqueous-extract-potential-nanoshuttles-for-brain-delivery-of-phenolic-compounds
#8
Simona Mancini, Luca Nardo, Maria Gregori, Inês Ribeiro, Francesco Mantegazza, Cristina Delerue-Matos, Massimo Masserini, Clara Grosso
BACKGROUND: Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2 O2 ) scavenger. PURPOSE: In order to protect this extract from gastrointestinal biotransformation and to improve its permeability across the blood-brain barrier (BBB), four phospholipid nanoformulations of liposomes and phytosomes functionalized with a peptide ligand promoting BBB crossing were produced...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29588159/a-brain-targeting-functionalized-liposomes-of-the-dopamine-derivative-n-3-4-bis-pivaloyloxy-dopamine-for-treatment-of-parkinson-s-disease
#9
Mengke Qu, Qing Lin, Shanshan He, Luyao Wang, Yao Fu, Zhirong Zhang, Ling Zhang
Parkinson's disease (PD) remains one of the most common neurodegenerative movement disorders with limited treatment options available. A dopamine derivative N-3,4-bis(pivaloyloxy)-dopamine (BPD) previously developed in our group has demonstrated superior therapeutic outcome compared to levodopa in a PD mice model. To further improve the therapeutic performance of BPD, a brain targeted drug delivery system was designed using a 29 amino-acid peptide (RVG29) derived from rabies virus glycoprotein as the targeting ligand...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29558440/transferrin-functionalized-liposomes-loading-dopamine-hcl-development-and-permeability-studies-across-an-in-vitro-model-of-human-blood-brain-barrier
#10
Antonio Lopalco, Annalisa Cutrignelli, Nunzio Denora, Angela Lopedota, Massimo Franco, Valentino Laquintana
The transport of dopamine across the blood brain barrier represents a challenge for the management of Parkinson's disease. The employment of central nervous system targeted ligands functionalized nanocarriers could be a valid tactic to overcome this obstacle and avoid undesirable side effects. In this work, transferrin functionalized dopamine-loaded liposomes were made by a modified dehydration-rehydration technique from hydrogenated soy phosphatidylcoline, cholesterol and 1,2-stearoyl- sn -glycero-3-phosphoethanolamine- N -[carboxy(poly(ethylene glycol)-2000)]...
March 20, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29455370/incomplete-copolymer-degradation-of-in-situ-chemotherapy
#11
Pierre Bourdillon, Tanguy Boissenot, Lauriane Goldwirt, Julien Nicolas, Caroline Apra, Alexandre Carpentier
In situ carmustine wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) are commonly used for the treatment of recurrent glioblastoma to overcome the brain-blood barrier. In theory, this chemotherapy diffuses into the adjacent parenchyma and the excipient degrades in maximum 8 weeks but no clinical data confirms this evolution, because patients are rarely operated again. A 75-year-old patient was operated twice for recurrent glioblastoma, and a carmustine wafer was implanted during the second surgery...
February 17, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29424324/nano-medicine-as-a-newly-emerging-approach-to-combat-human-immunodeficiency-virus-hiv
#12
Muthupandian Saravanan, Tsehaye Asmalash, Atsebaha Gebrekidan, Dawit Gebreegziabiher, Tadele Araya, Haftamu Hilekiros, Hamed Barabadi, Kumaresan Ramanathan
BACKGROUND: Human Immuno deficiency Virus (HIV) infection has attained pandemic level due to its complexity on both the HIV infection cycle and on the targets for drug delivery. This limits medication and consequently requires prominent and promising drug delivery systems to be invented. Notably, various nanomaterial have been studied to enhance effective delivery of the antiretroviral drugs for HIV prevention, diagnosis and cure. Some of these nanomaterials are liposomes, dendrimers, inorganic nanoparticles (NPs), polymeric micelles, natural and synthetic polymers...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29385922/a-review-of-potential-applications-of-mr-guided-focused-ultrasound-for-targeting-brain-tumor-therapy
#13
Layton Lamsam, Eli Johnson, Ian D Connolly, Max Wintermark, Melanie Hayden Gephart
Magnetic resonance-guided focused ultrasound (MRgFUS) has been used extensively to ablate brain tissue in movement disorders, such as essential tremor. At a lower energy, MRgFUS can disrupt the blood-brain barrier (BBB) to allow passage of drugs. This focal disruption of the BBB can target systemic medications to specific portions of the brain, such as for brain tumors. Current methods to bypass the BBB are invasive, as the BBB is relatively impermeable to systemically delivered antineoplastic agents. Multiple healthy and brain tumor animal models have suggested that MRgFUS disrupts the BBB and focally increases the concentration of systemically delivered antitumor chemotherapy, immunotherapy, and gene therapy...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385087/optimization-of-the-preparation-conditions-of-borneol-modified-ginkgolide-liposomes-by-response-surface-methodology-and-study-of-their-blood-brain-barrier-permeability
#14
Zhiyang Lv, Yuwei Yang, Jie Wang, Jing Chen, Junsong Li, Liuqing Di
Ginkgolides (GG), containing ginkgolide A (GA), ginkgolide B (GB) and ginkgolide C (GC), are mainly prescribed for ischemic stroke and cerebral infarction. However, the ginkgolides can hardly pass the blood-brain barrier (BBB) into the brain. The purpose of this study was to prepare borneol-modified ginkgolides liposomes (GGB-LPs) to study whether borneol could enhance the transport of ginkgolides across the BBB. The preparation conditions of GGB-LPs were optimized by a response surface-central composite design...
January 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29378465/development-a-hyaluronic-acid-ion-pairing-liposomal-nanoparticle-for-enhancing-anti-glioma-efficacy-by-modulating-glioma-microenvironment
#15
Liuqing Yang, Xu Song, Ting Gong, Kejun Jiang, Yingying Hou, Tijia Chen, Xun Sun, Zhirong Zhang, Tao Gong
Glioma, one of the most common brain tumors, remains a challenge worldwide. Due to the specific biological barriers such as blood-brain barrier (BBB), cancer stem cells (CSCs), tumor associated macrophages (TAMs), and vasculogenic mimicry channels (VMs), a novel versatile targeting delivery for anti-glioma is in urgent need. Here, we designed a hyaluronic acid (HA) ion-pairing nanoparticle. Then, these nanoparticles were encapsulated in liposomes, termed as DOX-HA-LPs, which showed near-spherical morphology with an average size of 155...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29376461/the-ability-of-liposomes-tailored-for-blood-brain-barrier-targeting-to-reach-the-brain-is-dramatically-affected-by-the-disease-state
#16
Roberta Dal Magro, Alysia Cox, Vanessa Zambelli, Simona Mancini, Massimo Masserini, Francesca Re
AIM: To investigate if and how the ability of liposomes, previously designed for Alzheimer's therapy, to reach the brain changes in aging/pathological conditions with respect to the healthy state. METHODS: Biodistribution and pharmacokinetics of liposomes in young or aged healthy mice and in an Alzheimer's mouse model were measured by radiochemical techniques. The expression of brain receptors and structural proteins was evaluated by Western blot. RESULTS: At equal blood levels, the amount and integrity of liposomes in the brain were dramatically lower in Alzheimer's or aged mice, with respect to young animals...
March 2018: Nanomedicine
https://www.readbyqxmd.com/read/29368289/liposomal-irinotecan-accumulates-in-metastatic-lesions-crosses-the-blood-tumor-barrier-btb-and-prolongs-survival-in-an-experimental-model-of-brain-metastases-of-triple-negative-breast-cancer
#17
Afroz S Mohammad, Jessica I Griffith, Chris E Adkins, Neal Shah, Emily Sechrest, Emma L Dolan, Tori B Terrell-Hall, Bart S Hendriks, Helen Lee, Paul R Lockman
PURPOSE: The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive permeability we hypothesize that liposomal irinotecan would improve local exposure of irinotecan and its active metabolite SN-38 in brain metastases relative to conventional irinotecan due to enhanced-permeation and retention (EPR) effect. METHODS: Female nude mice were intracardially or intracranially implanted with human brain seeking breast cancer cells (brain metastases of breast cancer model)...
January 9, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29339208/targeted-shrna-loaded-liposome-complex-combined-with-focused-ultrasound-for-blood-brain-barrier-disruption-and-suppressing-glioma-growth
#18
Guanjian Zhao, Qin Huang, Feng Wang, Xiang Zhang, Jiangang Hu, Ying Tan, Ning Huang, Zhigang Wang, Zhibiao Wang, Yuan Cheng
Our previous studies have demonstrated that focused ultrasound (FUS) combined with DNA-loaded microbubbles (MBs) can induce noninvasive, reversible, local disruption of the blood brain barrier (BBB) and enable targeted exogenous gene transfer into the central nervous system. However, due to low gene loading or the absence of positive targeting, to date, there has been no therapeutic effect of MBs combined with FUS in tumor treatment. In the current study, we adopted a phospholipid complex that exhibited sufficient gene loading and peptide-mediated targeting to delay glioma growth...
April 1, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29243575/nanomedicine-strategies-for-sustained-controlled-and-targeted-treatment-of-alzheimer-s-disease
#19
Tian-Jun Ma, Jie Gao, Yan Liu, Jian-Hua Zhuang, Chuan Yin, Peng Li, Lei Mao, Jin Xu, Yi-Xin Xu, Yan-Peng Li, Zhong-Xin Zhao, You Yin
Background Alzheimer's disease (AD) is one of the most devastating diseases worldwide. The current drugs for AD can only ameliorate the symptoms rather than reverse or prevent the progress of AD. On the other hand, blood-brain barrier (BBB), as a natural barrier, significantly impedes drug delivery from the blood circulation into the brain. Nanomedicine can be a safe, effective and promising approach to treat AD. Objective This review summarizes the recent nanomedicine research in this area, including the use of liposomes and nanoparticles (NPs), to provide new approach for targeted treatment of AD...
December 15, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29210401/hybrid-magneto-plasmonic-liposomes-for-multimodal-image-guided-and-brain-targeted-hiv-treatment
#20
Asahi Tomitaka, Hamed Arami, Zaohua Huang, Andrea Raymond, Elizette Rodriguez, Yong Cai, Marcelo Febo, Yasushi Takemura, Madhavan Nair
Image-guided drug delivery is an emerging strategy in the field of nanomedicine. The addition of image guidance to a traditional drug delivery system is expected to achieve highly efficient treatment by tracking the drug carriers in the body and monitoring their effective accumulation in the targeted tissues. In this study, we developed multifunctional magneto-plasmonic liposomes (MPLs), a hybrid system combining liposomes and magneto-plasmonic nanoparticles for a triple-modality image-guided drug delivery...
December 21, 2017: Nanoscale
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