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REVIEW
Toby Rogers, Adrienne E Campbell-Washburn, Rajiv Ramasawmy, D Korel Yildirim, Christopher G Bruce, Laurie P Grant, Annette M Stine, Aravindan Kolandaivelu, Daniel A Herzka, Kanishka Ratnayaka, Robert J Lederman
Transcatheter cardiovascular interventions increasingly rely on advanced imaging. X-ray fluoroscopy provides excellent visualization of catheters and devices, but poor visualization of anatomy. In contrast, magnetic resonance imaging (MRI) provides excellent visualization of anatomy and can generate real-time imaging with frame rates similar to X-ray fluoroscopy. Realization of MRI as a primary imaging modality for cardiovascular interventions has been slow, largely because existing guidewires, catheters and other devices create imaging artifacts and can heat dangerously...
August 14, 2023: Journal of Cardiovascular Magnetic Resonance
#22
JOURNAL ARTICLE
Giorgio A Medranda, Toby Rogers, Brian C Case, Cheng Zhang, Matteo Cellamare, Corey Shea, Hank Rappaport, Jeffrey E Cohen, Christian C Shults, Itsik Ben-Dor, Lowell F Satler, Ron Waksman
BACKGROUND/PURPOSE: The cusp overlap technique has standardized implantation for self-expanding valves with the goal of achieving more consistent implantation depths and lowering permanent pacemaker (PPM) implantation rates. We retrospectively compared short-term outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) with a self-expanding valve implanted using the cusp overlap technique vs. the traditional coplanar technique in a large tertiary referral center. METHODS: We conducted a retrospective study among PPM-naïve patients who underwent TAVR using the CoreValve Evolut PRO/PRO+...
July 29, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#23
JOURNAL ARTICLE
Toby Rogers, Christopher G Bruce
No abstract text is available yet for this article.
August 7, 2023: EuroIntervention
#24
JOURNAL ARTICLE
Max Eriksson, Mohammad Safeeq, Lace Padilla, Tapan Pathak, Toby O'Geen, Benis Egoh, Jaquelyn Lugg, Roger Bales
The social impacts of natural resource management are challenging to evaluate because their perceived benefits and costs vary across stakeholder groups. Nevertheless, ensuring social acceptance is essential to building public support for adaptive measures required for the sustainable management of ecosystems in a warming climate. Based on surveys with both members of the public and natural-resource professionals in California, we applied structural-equation modeling to examine how psychological factors impact individuals' attitudes toward management's capacity to reduce the impacts of disturbance events, including wildfires, smoke from wildfires, drought, water shortages, tree mortality, and utility failure...
July 21, 2023: Journal of Environmental Management
#25
JOURNAL ARTICLE
Sukhdeep Bhogal, Toby Rogers, Ilan Merdler, Pavan Reddy, Syed Ali, Corey Shea, Cheng Zhang, Itsik Ben-Dor, Lowell F Satler, Ron Waksman
BACKGROUND: The self-expanding CoreValve Evolut PRO/PRO+ transcatheter aortic valve was designed to overcome the limitations of its forerunner, Evolut R. Evolut PRO/PRO+ offers the lowest delivery profile for 23-29 mm valves, with an external tissue wrap on all valve sizes. We compared safety and efficacy of Evolut PRO/PRO+ and Evolut R. METHODS: We analyzed 300 patients enrolled in the EPROMPT Registry against a historical control cohort of 242 patients who received Evolut R...
July 19, 2023: International Journal of Cardiology
#26
JOURNAL ARTICLE
Ilan Merdler, Brian Case, Sukhdeep Bhogal, Pavan K Reddy, Vaishnavi Sawant, Cheng Zhang, Syed Ali, Itsik Ben-Dor, Lowell F Satler, Toby Rogers, Ron Waksman
BACKGROUND: The Evolut FX system is the most recent generation of self-expandable transcatheter heart valve (THV) technology. This study aims to report the early experience and outcomes associated with this system. METHODS: Our analysis included 200 consecutive patients who underwent transcatheter aortic valve replacement at our center from 2022 to 2023. The first cohort comprised the last 100 patients who received the Evolut PRO+ THV, while the second cohort included the first 100 patients who received the Evolut FX THV...
June 5, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#27
JOURNAL ARTICLE
Amer I Aladin, Tareq Arar, Fnu Lubaina, Sukhdeep Bhogal, Cheng Zhang, Jason P Wermers, Itsik Ben-Dor, Lowell F Satler, Toby Rogers, Michael Slack, Ron Waksman
PURPOSE: Explore gender disparities in patients undergoing transseptal puncture (TSP) for selected transcatheter cardiac intervention procedures. METHODS: Patients who underwent TSP from January 2015 through September 2021 were reviewed. Primary outcomes were procedural and in-hospital major adverse events. Secondary endpoints were procedural success and hospitalization length of stay (LOS) >1 day. Unadjusted and multivariable-adjusted logistic regression analyses were performed to assess gender differences for in-hospital adverse events...
June 24, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#28
JOURNAL ARTICLE
Christopher G Bruce, D Korel Yildirim, Aravindan Kolandaivelu, Jaffar M Khan, Toby Rogers, Dogangun Uzun, Andrea E Jaimes, Rim N Halaby, Daniel A Herzka, Vasilis C Babaliaros, Adam B Greenbaum, Robert J Lederman
BACKGROUND: Intramyocardial guidewire navigation is a novel technique that allows free transcatheter movement within ventricular muscle. Guidewire radial depth, between endocardial and epicardial surfaces, is ambiguous by x-ray and echocardiography. OBJECTIVES: The aim of this study was to develop a simple tool, EDEN (Electrocardiographic Radial Depth Navigation), to indicate radial depth during intramyocardial guidewire navigation. Combined with routine imaging, EDEN facilitates a new family of intramyocardial catheter procedures to slice, reshape, pace, and ablate the heart...
May 20, 2023: JACC. Clinical Electrophysiology
#29
JOURNAL ARTICLE
Michael J Roy, Minglyanna G Surudoi, Ashleigh Kropp, Jianmei Hou, Weiwen Dai, Joshua M Hardy, Lung-Yu Liang, Thomas R Cotton, Bernhard C Lechtenberg, Toby A Dite, Xiuquan Ma, Roger J Daly, Onisha Patel, Isabelle S Lucet
PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. Here, we elucidate the molecular details of key PEAK signaling interactions with the adapter proteins CrkII and Grb2 and the scaffold protein 14-3-3. Our findings rationalize why the dimerization of PEAK proteins has a crucial function in signal transduction and provide biophysical and structural data to unravel binding specificity within the PEAK interactome...
June 19, 2023: Nature Communications
#30
Mark Blaxill, Toby Rogers, Cynthia Nevison
No abstract text is available yet for this article.
June 5, 2023: Journal of Autism and Developmental Disorders
#31
REVIEW
César E Soria Jiménez, Alexander I Papolos, Benjamin B Kenigsberg, Itsik Ben-Dor, Lowell F Satler, Ron Waksman, Jeffrey E Cohen, Toby Rogers
Mechanical prosthetic heart valves, though more durable than bioprostheses, are more thrombogenic and require lifelong anticoagulation. Mechanical valve dysfunction can be caused by 4 main phenomena: 1) thrombosis; 2) fibrotic pannus ingrowth; 3) degeneration; and 4) endocarditis. Mechanical valve thrombosis (MVT) is a known complication with clinical presentation ranging from incidental imaging finding to cardiogenic shock. Thus, a high index of suspicion and expedited evaluation are essential. Multimodality imaging, including echocardiography, cine-fluoroscopy, and computed tomography, is commonly used to diagnose MVT and follow treatment response...
May 30, 2023: Journal of the American College of Cardiology
#32
MULTICENTER STUDY
Ron Waksman, Sukhdeep Bhogal, Paul Gordon, Afshin Ehsan, Sean R Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Nicholas Hanna, Maurice Buchbinder, Federico M Asch, Francis Y Kim, Gaby Weissman, Itsik Ben-Dor, Christian C Shults, Syed Ali, Joseph A Sutton, Corey Shea, Cheng Zhang, Hector M Garcia-Garcia, Lowell F Satler, Toby Rogers
BACKGROUND: The LRT trial (Low-Risk Transcatheter Aortic Valve Replacement [TAVR]) demonstrated the safety and feasibility of TAVR in low-risk patients, with excellent 1- and 2-year outcomes. The objective of the current study is to provide the overall clinical outcomes and the impact of 30-day hypoattenuated leaflet thickening (HALT) on structural valve deterioration at 4 years. METHODS: The prospective, multicenter LRT trial was the first Food and Drug Administration-approved investigational device exemption study to evaluate feasibility and safety of TAVR in low-risk patients with symptomatic severe tricuspid aortic stenosis...
May 2023: Circulation. Cardiovascular Interventions
#33
JOURNAL ARTICLE
Kendra J Grubb, Nikoloz Shekiladze, Julianne Spencer, Emily Perdoncin, Gilbert H L Tang, Joe Xie, John Lisko, Jorge Zhingre Sanchez, Lindsay M Lucas, Janarthanan Sathananthan, Toby Rogers, G Michael Deeb, Shinichi Fukuhara, Philipp Blanke, Jonathon A Leipsic, John K Forrest, Michael J Reardon, Patrick Gleason
BACKGROUND: Transcatheter aortic valve implantation in an existing transcatheter valve (redo-TAVI) pins the index valve leaflets in the open position (neoskirt), which can cause coronary flow compromise and limit access. Whether anatomy may preclude redo-TAVI in self-expanding Evolut valves is unknown. AIMS: We aimed to evaluate the anatomical feasibility of redo-TAVI by simulating implantation of a balloon-expandable SAPIEN 3 (S3) within an Evolut or an Evolut within an Evolut...
April 17, 2023: EuroIntervention
#34
JOURNAL ARTICLE
Vinay Udyawer, Charlie Huveneers, Fabrice Jaine, Russell C Babcock, Stephanie Brodie, Marie-Jeanne Buscot, Hamish A Campbell, Robert G Harcourt, Xavier Hoenner, Elodie J I Lédée, Colin A Simpfendorfer, Matthew D Taylor, Asia Armstrong, Adam Barnett, Culum Brown, Barry Bruce, Paul A Butcher, Gwenael Cadiou, Lydie I E Couturier, Leanne Currey-Randall, Michael Drew, Christine L Dudgeon, Ross G Dwyer, Mario Espinoza, Luciana C Ferreira, Anthony Fowler, David Harasti, Alastair R Harborne, Nathan A Knott, Kate Lee, Matt Lloyd, Michael Lowry, Teagan Marzullo, Jordan Matley, Jaime D McAllister, Rory McAuley, Frazer McGregor, Mark Meekan, Kade Mills, Bradley M Norman, Beverly Oh, Nicholas L Payne, Vic Peddemors, Toby Piddocke, Richard D Pillans, Richard D Reina, Paul Rogers, Jayson M Semmens, Amy Smoothey, Conrad W Speed, Dylan van der Meulen, Michelle R Heupel
AbstractUnifying models have shown that the amount of space used by animals (e.g., activity space, home range) scales allometrically with body mass for terrestrial taxa; however, such relationships are far less clear for marine species. We compiled movement data from 1,596 individuals across 79 taxa collected using a continental passive acoustic telemetry network of acoustic receivers to assess allometric scaling of activity space. We found that ectothermic marine taxa do exhibit allometric scaling for activity space, with an overall scaling exponent of 0...
April 2023: American Naturalist
#35
JOURNAL ARTICLE
Jaffar M Khan, Norihiko Kamioka, John C Lisko, Emily Perdoncin, Cheng Zhang, Aneel Maini, Mao Chen, Yijian Li, Sebastian Ludwig, Dirk Westermann, Ignacio J Amat Santos, Łukasz Kalińczuk, Jan-Malte Sinning, Tomohiro Kawaguchi, Yasushi Fuku, Asim N Cheema, Afonso Félix-Oliveira, Masanori Yamamoto, Ai Kagase, Pablo Codner, Raquel Del Valle, Vijay S Iyer, Hyo-Soo Kim, Mao-Shin Lin, Brijeshwar Maini, Roberto Rodriguez, Matteo Montorfano, Marco B Ancona, Norio Tada, Masaki Miyasaka, Hasan Ahmad, Nicholas J Ruggiero, Rebecca Torguson, Itsik Ben-Dor, Christian C Shults, Gaby Weissman, Robert J Lederman, Adam B Greenbaum, Vasilis C Babaliaros, Ron Waksman, Toby Rogers
BACKGROUND: Transcatheter aortic valve replacement (TAVR)-related coronary artery obstruction prediction remains unsatisfactory despite high mortality and novel preventive therapies. OBJECTIVES: This study sought to develop a predictive model for TAVR-related coronary obstruction in native aortic stenosis. METHODS: Preprocedure computed tomography and fluoroscopy images of patients in whom TAVR caused coronary artery obstruction were collected...
February 27, 2023: JACC. Cardiovascular Interventions
#36
REVIEW
Robert J Lederman, Adam B Greenbaum, Jaffar M Khan, Christopher G Bruce, Vasilis C Babaliaros, Toby Rogers
Transcaval aortic access is a versatile electrosurgical technique for large-bore arterial access through the wall of the abdominal aorta from the adjoining inferior vena cava. Although counterintuitive, its relative safety derives from the recognition that interstitial hydraulic pressure exceeds venous pressure, so arterial bleeding harmlessly decompresses into the nearby caval venous hole. Transcaval access has been performed in thousands of patients for transcatheter aortic valve replacement and endovascular thoracic aneurysm repair and to avoid limb ischemia in percutaneous mechanical circulatory support...
February 27, 2023: JACC. Cardiovascular Interventions
#37
REVIEW
Sukhdeep Bhogal, Toby Rogers, Amer Aladin, Itsik Ben-Dor, Jeffrey E Cohen, Christian C Shults, Jason P Wermers, Gaby Weissman, Lowell F Satler, Michael J Reardon, Steven J Yakubov, Ron Waksman
Since the first transcatheter delivery of an aortic valve prosthesis was performed by Cribier et al in 2002, the picture of aortic stenosis (AS) therapeutics has changed dramatically. Initiated from an indication of inoperable to high surgical risk, extending to intermediate and low risk, transcatheter aortic valve replacement (TAVR) is now an approved treatment for patients with severe, symptomatic AS across all the risk categories. The current evidence supports TAVR as a frontline therapy for treating severe AS...
April 15, 2023: American Journal of Cardiology
#38
REVIEW
Christopher G Bruce, Jaffar M Khan, Toby Rogers, D Korel Yildirim, Vasilis C Babaliaros, Adam B Greenbaum, Robert J Lederman
Transcatheter electrosurgery describes the ability to cut and traverse tissue, at a distance, without an open surgical field and is possible using either purpose-built or off-the-shelf devices. Tissue traversal requires focused delivery of radiofrequency energy to a guidewire tip. Initially employed to cross atretic pulmonary valves, tissue traversal has enabled transcaval aortic access, recanalization of arterial and venous occlusions, transseptal access, and many other techniques. To cut tissue, the selectively denuded inner curvature of a kinked guidewire (the Flying-V) or a single-loop snare is energized during traction...
March 2023: Circulation. Cardiovascular Interventions
#39
JOURNAL ARTICLE
Christopher G Bruce, Jaffar M Khan, Toby Rogers, D Korel Yildirim, Andrea E Jaimes, Felicia Seemann, Marcus Y Chen, Kendall O'Brien, Daniel A Herzka, William H Schenke, Michael A Eckhaus, Amanda G Potersnak, Adrienne Campbell-Washburn, Vasilis C Babaliaros, Adam B Greenbaum, Robert J Lederman
MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance...
January 2023: JACC. Basic to Translational Science
#40
JOURNAL ARTICLE
Giorgio A Medranda, Ezequiel J Molina, Toby Rogers, Ryan Kabir, Cheng Zhang, Hank Rappaport, Brian C Case, Itsik Ben-Dor, Christian C Shults, Lowell F Satler, Ron Waksman
Surgical aortic valve replacement (SAVR) remains the standard of care for patients with chronic severe aortic regurgitation (AR). The introduction of a dedicated transcatheter heart valve for AR has fueled interest in using transcatheter aortic valve replacement to treat patients with isolated AR. We aimed to characterize the profile and outcomes of patients with symptomatic severe AR who underwent isolated SAVR. We conducted a retrospective, observational study of patients who underwent isolated SAVR for symptomatic severe AR at our institution...
April 1, 2023: American Journal of Cardiology
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