keyword
https://read.qxmd.com/read/38474689/biodegradable-metal-complex-gated-organosilica-for-dually-enhanced-chemodynamic-therapy-through-gsh-depletions-and-nir-light-triggered-photothermal-effects
#1
JOURNAL ARTICLE
Lin Kong, Jian Li, Yunxiu Zhang, Jian Wang, Ke Liang, Xiaokuang Xue, Tiejin Chen, Yongliang Hao, Haohui Ren, Pengfei Wang, Jiechao Ge
Hollow silica spheres have been widely studied for drug delivery because of their excellent biosecurity and high porosity. However, difficulties with degradation in the tumor microenvironment (TME) and premature leaking during drug delivery limit their clinical applications. To alleviate these problems, herein, hollow organosilica spheres (HOS) were initially prepared using a "selective etching strategy" and loaded with a photothermal drug: new indocyanine green (IR820). Then, the Cu2+ -tannic acid complex (Cu-TA) was deposited on the surface of the HOS, and a new nanoplatform named HOS@IR820@Cu-TA (HICT) was finally obtained...
March 6, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38396962/glioblastoma-associated-mesenchymal-stem-stromal-cells-and-cancer-associated-fibroblasts-partners-in-crime
#2
REVIEW
Thibault Lootens, Bart I Roman, Christian V Stevens, Olivier De Wever, Robrecht Raedt
Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as attractive therapeutic targets in several cancer types, due to their ability to enhance tumor growth and angiogenesis and their contribution to an immunosuppressive tumor microenvironment (TME). In glioblastoma (GB), mesenchymal stem cells (MSCs) seem to be recruited to the tumor site, where they differentiate into glioblastoma-associated mesenchymal stem/stromal cells (GA-MSCs) under the influence of tumor cells and the TME. GA-MSCs are reported to exert important protumoral functions, such as promoting tumor growth and invasion, increasing angiogenesis, stimulating glioblastoma stem cell (GSC) proliferation and stemness, mediating resistance to therapy and contributing to an immunosuppressive TME...
February 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38312128/mechanisms-and-therapeutic-strategies-to-combat-the-recurrence-and-progression-of-hepatocellular-carcinoma-after-thermal-ablation
#3
JOURNAL ARTICLE
Feilong Ye, Lulu Xie, Licong Liang, Zhimei Zhou, Siqin He, Rui Li, Liteng Lin, Kangshun Zhu
Thermal ablation (TA), including radiofrequency ablation (RFA) and microwave ablation (MWA), has become the main treatment for early-stage hepatocellular carcinoma (HCC) due to advantages such as safety and minimal invasiveness. However, HCC is prone to local recurrence, with more aggressive malignancies after TA closely related to TA-induced changes in epithelial-mesenchymal transition (EMT) and remodeling of the tumor microenvironment (TME). According to many studies, various components of the TME undergo complex changes after TA, such as the recruitment of innate and adaptive immune cells, the release of tumor-associated antigens (TAAs) and various cytokines, the formation of a hypoxic microenvironment, and tumor angiogenesis...
November 2023: J Interv Med
https://read.qxmd.com/read/38256571/incidence-and-risk-factors-for-low-anterior-resection-syndrome-following-trans-anal-total-mesorectal-excision
#4
JOURNAL ARTICLE
Shani Y Parnasa, Ido Mizrahi, Brigitte Helou, Adiel Cohen, Mahmoud Abu Gazala, Alon J Pikarsky, Noam Shussman
BACKGROUND: Trans-anal total mesorectal excision (Ta-TME) is a novel approach for the resection of rectal cancer. Low anterior resection syndrome (LARS) is a frequent functional disorder that might follow restorative proctectomy. Data regarding bowel function after Ta-TME are scarce. The aim of this study was to evaluate the incidence and risk factors for the development of LARS following Ta-TME. METHODS: A prospectively maintained database of all patients who underwent Ta-TME for rectal cancer at our institution was reviewed...
January 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38142082/injectable-alginate-hydrogel-promotes-antitumor-immunity-through-glucose-oxidase-and-fe-3-amplified-rsl3-induced-ferroptosis
#5
JOURNAL ARTICLE
Kai Chen, Lei Gu, Qianfeng Zhang, Qiang Luo, Shiwei Guo, Bing Wang, Qiyong Gong, Kui Luo
Ferroptosis induced by RAS-selective lethal small molecule 3 (RSL3) can trigger anti-tumor immune responses by reversing the immunosuppressive tumor microenvironment (TME). However, it is challenging to achieve sufficient ferroptosis in the tumor via RSL3 alone. Because of the excellent reactive oxygen species (ROS) production capacity of glucose oxidase (GOx) and Fe3+ , we hypothesized that GOx and Fe3+ could increase intracellular lipid peroxidation (LPO) accumulation, and strengthen RSL3-induced ferroptosis in tumor cells...
February 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38115305/pan-cancer-analysis-reveals-the-characteristics-and-roles-of-tooth-agenesis-mutant-genes
#6
JOURNAL ARTICLE
Yating Liu, Jie Yang, Xinyu Li, Shanshan Chen, Changyu Zhu, Yijun Shi, Shoutao Dang, Weitao Zhang, Wei Li
Tooth development is regulated by numerous genes and signaling pathways. Some studies suggest that mutations in these genes may be associated with several cancer types. However, the tooth agenesis mutated genes role in the prognosis and their clinical therapeutic potentials in pan-cancer have not been elaborately explored. Moreover, the intrinsic correlation between tooth agenesis and cancers also needs to be further verified. We preliminarily analyzed expression levels and prognostic values of causative genes of tooth agenesis, and explored the correlation between the expression of tooth agenesis mutated genes and TME, Stemness score, clinical characteristic, immune subtype, and drug sensitivity in pan-cancer, which based on updated public databases and integrated some bioinformatics analysis methods...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37950749/chimeric-antigen-receptor-based-immunotherapy-in-breast-cancer-recent-progress-in-china
#7
REVIEW
Tianze Yu, Yuexin Lu, Jianwen Fang, Xiaocong Jiang, Yue Lu, Jingyan Zheng, Xi Shang, Haixing Shen, Peifen Fu
Breast cancer (BC) is the fourth most prevalent cancer in China. Despite conventional treatment strategies, BC patients often have poor therapeutic outcomes, leading to significant global cancer mortality rates. Chimeric antigen receptor (CAR)-based immunotherapy is a promising and innovative approach for cancer treatment that redirects immune cells to attack tumor cells expressing selected tumor antigens (TAs). T cells, natural killer (NK) cells, and macrophages, key components of the immune system, are used in CAR-based immunotherapies...
November 11, 2023: Cancer
https://read.qxmd.com/read/37777573/high-endothelial-venules-predict-response-to-pd-1-inhibitors-combined-with-anti-angiogenesis-therapy-in-nsclc
#8
JOURNAL ARTICLE
Dafu Ye, Yao Jin, Yiming Weng, Xue Cui, Jinsong Wang, Min Peng, Qibin Song
Tumor-associated high endothelial venules (TA-HEVs) mediate lymphocyte entry into tumors. Therefore, combined anti-angiogenesis therapy and programmed death-1 (PD-1) inhibitors might stimulate tumor immunity. This study will explore the TA-HEVs and real-world data of the combination therapy in non-small cell lung cancer (NSCLC). Firstly, we found a certain relationship between HEVs and immune effector cells by multiple immunofluorescence staining. We then analyzed the efficacy of immunotherapy combined with anti-angiogenesis therapy in advanced NSCLC patients by collecting real-world clinical data...
September 30, 2023: Scientific Reports
https://read.qxmd.com/read/37660642/role-of-cancer-educated-mesenchymal-stromal-cells-on-tumor-progression
#9
REVIEW
Ting Liu, Shuwei Guo, Yong Ji, Wei Zhu
The malignant tumor is the main cause of human deaths worldwide. Current therapies focusing on the tumor itself have achieved unprecedented benefits. Various pro-tumorigenic factors in the tumor microenvironment (TME) could abolish the effect of cancer therapy. Mesenchymal stromal cells (MSCs) are one of the substantial components in the tumor microenvironment, contributing to tumor progression. However, MSCs are not inherently tumor-promoting. Indeed, they acquire pro-tumorigenic properties under the education of the TME...
September 1, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37615117/the-multifunction-role-of-tumor-associated-mesenchymal-stem-cells-and-their-interaction-with-immune-cells-in-breast-cancer
#10
REVIEW
Anita Chauhan, Sonam Agarwal, Marilyn Masih, Pramod Kumar Gautam
Mesenchymal stem cells (MSCs) are a heterogeneous group of progenitor cells that play a multifunctional role including tissue regeneration, self-renewal properties, and differentiate into cells of mesodermal lineage such as adipocytes, osteoblasts, and chondrocytes. MSCs come into contact with tumor microenvironment (TME) and differentiate into tumor-associated MSCs (TA-MSCs). Various substances such as chemokines, cytokines, growth factors, and others are released by tumor cells to recruit MSCs. TA-MSCs induced epithelial-mesenchymal transition (EMT) program which mediates tumor growth progression, migration, and invasion...
August 24, 2023: Immunological Investigations
https://read.qxmd.com/read/37549506/a-tumor-microenvironment-activatable-nanoplatform-with-phycocyanin-assisted-in-situ-nanoagent-generation-for-synergistic-treatment-of-colorectal-cancer
#11
JOURNAL ARTICLE
Xiaoxiao Sun, Xiaoye Liang, YuKai Wang, Pengcheng Ma, Weiwei Xiong, Shiyu Qian, Yu Cui, Haiyang Zhang, Xiang Chen, Fang Tian, Yang Shi, Fenfen Zheng, Lingling Li
The in-situ generation of therapeutic agents in targeted lesions is promising for revolutionizing oncotherapy but is limited by the low production efficiency. Given the specific tumor microenvironment (TME) of colorectal cancer (CRC), i.e., mild acidity, overexpressed H2 O2 , glutathione (GSH) and H2 S, we develop phycocyanin (PC) encapsulated PZTC/SS/HA nanocapsules (NCs) for TME-responsive, protein-assisted "turn-on'' therapy of CRC. The NCs are prepared by sequentially assembling Cu2+ -tannic acid (TA) coordination shell, disulfide bond-bearing cross-linker, and hyaluronic acid (HA) on the sacrificial template ZIF-8, thus achieving pH-, GSH-responsiveness, and tumor targeting capability, respectively...
July 31, 2023: Biomaterials
https://read.qxmd.com/read/37097660/transanal-total-mesorectal-excision-for-extended-surgery-in-the-early-stage-after-introduction
#12
JOURNAL ARTICLE
Shunjin Ryu, Takahiro Kitagawa, Keisuke Goto, Atsushi Nagashima, Takehiro Kobayashi, Junichi Shimada, Ryusuke Ito, Yukio Nakabayashi
BACKGROUND/AIM: The effectiveness of transanal total mesorectal excision (Ta-TME) in extended surgery (ES) has been discussed. This study examined the short-term outcomes of the first 31 patients who underwent Ta-TME after its introduction and verified the safety of Ta-TME in ES in the early stage following its introduction. PATIENTS AND METHODS: Thirty-one consecutive patients who underwent Ta-TME between December 2021 and January 2023 at our institution were included...
May 2023: Anticancer Research
https://read.qxmd.com/read/37075522/zn-2-interference-and-h-2-s-mediated-gas-therapy-based-on-zns-tannic-acid-nanoparticles-synergistic-enhancement-of-cell-apoptosis-for-specific-treatment-of-prostate-cancer
#13
JOURNAL ARTICLE
Bo Zhou, Ben-Xu Jia, Ming-Jin Zhang, Yan-Jun Tan, Wei-Yuan Liang, Xiang Gan, Hong-Tao Li, Xiaoli Yang, Xing-Can Shen
Zn2+ and H2 S are essential to maintain normal prostate function, and sometimes can evolve into weapons to attack and destroy prostate cancer (PCa) cells. Nevertheless, how to achieve the targeted and effective release of Zn2+ and H2 S, and reverse the concentration distribution within PCa tumor cells still highly challenging. Herein, combined with these pathological characteristics of prostate, we proposed a tumor microenvironment (TME) responsive Zn2+ -interference and H2 S-mediated gas synergistic therapy strategy based on a nanoplatform of tannic acid (TA) modified zinc sulfide nanoparticles (ZnS@TA) for the specific treatment of PCa...
April 12, 2023: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/36950394/utility-of-transversus-abdominis-plane-block-on-patients-undergoing-transanal-total-mesorectal-excision
#14
JOURNAL ARTICLE
Jun Ying, Chunhui Jiang, Chunjie Xu, Ye Liu, Lei Gu
OBJECTIVE: To evaluate the analgesic effect of transversus abdominis plane block (TAPB) on patients undergoing transanal total mesorectal excision (taTME). METHODS: Medical records of patients who were eligible to receive proctectomy surgery in Renji Hospital, Shanghai Jiao Tong University School of Medicine (From January 2019 to December 2021) were retrospectively reviewed. Propensity score matching (PSM) was applied to the included cases. A total of 120 cases were divided into three groups based on the different operation and anesthesia methods used...
2023: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/36813307/t-cell-mediated-targeted-delivery-of-tadalafil-regulates-immunosuppression-and-polyamine-metabolism-to-overcome-immune-checkpoint-blockade-resistance-in-hepatocellular-carcinoma
#15
JOURNAL ARTICLE
Xiaobin Wang, Qiaoyun Zhang, Jingwen Zhou, Zecong Xiao, Jianxin Liu, Shaohui Deng, Xiaoyang Hong, Wensou Huang, Mingyue Cai, Yongjian Guo, Jingjun Huang, Yong Wang, Liteng Lin, Kangshun Zhu
BACKGROUND: Immune checkpoint blockade (ICB) monotherapy provides poor survival benefit in hepatocellular carcinoma (HCC) due to ICB resistance caused by immunosuppressive tumor microenvironment (TME) and drug discontinuation resulting from immune-related side effects. Thus, novel strategies that can simultaneously reshape immunosuppressive TME and ameliorate side effects are urgently needed. METHODS: Both in vitro and orthotopic HCC models were used to explore and demonstrate the new role of a conventional, clinically used drug, tadalafil (TA), in conquering immunosuppressive TME...
February 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/36651135/nir-activated-multimodal-therapeutics-based-on-metal-phenolic-networks-functionalized-nanoplatform-for-combating-against-multidrug-resistance-and-metastasis
#16
JOURNAL ARTICLE
Chen Cheng, Weixi Jiang, Yuanli Luo, Li Wan, Xun Guo, Zhuoyan Xie, Rui Tang, Tong Huang, Jingxue Wang, Chier Du, Zhigang Wang, Haitao Ran, Pan Li, Zhiyi Zhou, Jianli Ren
Multidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal-phenolic network-functionalized nanoparticles (t-P@TFP NPs) are designed to realize multiple therapeutic modalities and reshape the TME from insensitive to sensitive under multimodal imaging monitoring. After a single irradiation, a near-infrared laser-activated multistage reaction occurs...
January 18, 2023: Small
https://read.qxmd.com/read/36639681/repurposing-nitric-oxide-donating-drugs-in-cancer-therapy-through-immune-modulation
#17
JOURNAL ARTICLE
Chung-Yen Li, Gangga Anuraga, Chih-Peng Chang, Tzu-Yang Weng, Hui-Ping Hsu, Hoang Dang Khoa Ta, Pei-Fang Su, Pin-Hsuan Chiu, Shiang-Jie Yang, Feng-Wei Chen, Pei-Hsuan Ye, Chih-Yang Wang, Ming-Derg Lai
BACKGROUND: Nitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less clear. Therefore, this study explored the impact of nitric oxide donors on tumor progression in immune-competent mice. METHODS: The effects of three different nitric oxide-releasing compounds (SNAP, SNP, and ISMN) on tumor growth were studied in tumor-bearing mouse models. Three mouse tumor models were used: B16F1 melanoma and LL2 lung carcinoma in C57BL/6 mice, CT26 colon cancer in BALB/c mice, and LL2 lung carcinoma in NOD/SCID mice...
January 14, 2023: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/36413576/author-response-to-comment-on-transanal-versus-laparoscopic-total-mesorectal-excision-for-mid-and-low-rectal-cancer-ta-latme-study-multicentre-randomized-open-label-trial
#18
MULTICENTER STUDY
Xavier Serra-Aracil, Laura Mora-López
No abstract text is available yet for this article.
January 10, 2023: British Journal of Surgery
https://read.qxmd.com/read/36413569/comment-on-transanal-versus-laparoscopic-total-mesorectal-excision-for-mid-and-low-rectal-cancer-ta-latme-study-multicentre-randomized-open-label-trial
#19
JOURNAL ARTICLE
Song Zhao, Weidong Tong
No abstract text is available yet for this article.
November 22, 2022: British Journal of Surgery
https://read.qxmd.com/read/36362062/pd-l1-expression-in-high-risk-early-stage-colorectal-cancer-its-clinical-and-biological-significance-in-immune-microenvironment
#20
JOURNAL ARTICLE
Bing-Syuan Chung, I-Chuang Liao, Peng-Chan Lin, Shang-Yin Wu, Jui-Wen Kang, Bo-Wen Lin, Po-Chuan Chen, Ren-Hao Chan, Chung-Ta Lee, Meng-Ru Shen, Shang-Hung Chen, Yu-Min Yeh
Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that can regulate immune responses in the tumor microenvironment (TME); however, the clinical applications of PD-L1 in early-stage colorectal cancer (CRC) remain unclear. In this study, we aimed to investigate the relationship between PD-L1 expression and survival outcome and explore its relevant immune responses in CRC. PD-L1 expression was evaluated by immunohistochemical staining to determine the tumor proportion score and combined positive score (CPS) in a Taiwanese CRC cohort...
October 31, 2022: International Journal of Molecular Sciences
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