Xiaoxiao Sun, Xiaoye Liang, YuKai Wang, Pengcheng Ma, Weiwei Xiong, Shiyu Qian, Yu Cui, Haiyang Zhang, Xiang Chen, Fang Tian, Yang Shi, Fenfen Zheng, Lingling Li
The in-situ generation of therapeutic agents in targeted lesions is promising for revolutionizing oncotherapy but is limited by the low production efficiency. Given the specific tumor microenvironment (TME) of colorectal cancer (CRC), i.e., mild acidity, overexpressed H2 O2 , glutathione (GSH) and H2 S, we develop phycocyanin (PC) encapsulated PZTC/SS/HA nanocapsules (NCs) for TME-responsive, protein-assisted "turn-on'' therapy of CRC. The NCs are prepared by sequentially assembling Cu2+ -tannic acid (TA) coordination shell, disulfide bond-bearing cross-linker, and hyaluronic acid (HA) on the sacrificial template ZIF-8, thus achieving pH-, GSH-responsiveness, and tumor targeting capability, respectively...
July 31, 2023: Biomaterials