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https://www.readbyqxmd.com/read/27271718/-total-mesorectal-excision-in-rectal-cancer-management-laparoscopic-or-transanal
#1
RANDOMIZED CONTROLLED TRIAL
A O Rasulov, Z Z Mamedli, Kh E Dzhumabaev, V M Kulushev, N A Kozlov
AIM: To evaluate and compare intraoperative features, early surgical outcomes, quality of excised specimen after laparoscopic and transanal total mesorectal excision (LA-TME and TA-TME). MATERIAL AND METHODS: Prospective randomized study included 45 patients with confirmed rectal adenocarcinoma (cT2-4N0-2M0) since October 2013. LA-TME and TA-TME groups consisted of 23 and 22 patients respectively. Inclusion criteria were patients with primary-operable rectal cancer and satisfactory response after neoadjuvant chemo- and radiotherapy...
2016: Khirurgiia
https://www.readbyqxmd.com/read/26943036/depletion-of-fap-cells-reduces-immunosuppressive-cells-and-improves-metabolism-and-functions-cd8-t-cells-within-tumors
#2
Ying Zhang, Hildegund C J Ertl
The tumor stroma, which is essential to support growth and metastasis of malignant cells, provides targets for active immunotherapy of cancer. Previous studies have shown that depleting fibroblast activation protein (FAP)-expressing stromal cells reduces tumor progression and concomitantly increases tumor antigen (TA)-specific T cell responses. However the underlying pathways remain ill defined. Here we identify that immunosuppressive cells (ISCs) from tumor-bearing mice impose metabolic stress on CD8+T cells, which is associated with increased expression of the co-inhibitor PD-1...
April 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/26497544/transanal-total-mesorectal-excision-for-rectal-cancer-a-single-center-experience-and-systematic-review-of-the-literature
#3
Nicola de'Angelis, Luca Portigliotti, Daniel Azoulay, Francesco Brunetti
PURPOSE: The present study aimed to compare the operative and oncologic results of transanal total mesorectum excision (Ta-TME) ("down-to-up") vs. laparoscopic TME (L-TME, "up-to-down") for low rectal cancer. Additionally, a systematic review of the literature was performed to assess the quality of the current body of evidence on Ta-TME. METHODS: The study population included 32 consecutive patients who underwent Ta-TME between January 2011 and December 2014 that were compared with a matched group of patients undergoing L-TME between January 2008 and December 2010...
December 2015: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/25566992/emt-transition-alters-interstitial-fluid-flow-induced-signaling-in-erbb2-positive-breast-cancer-cells
#4
Alimatou M Tchafa, Mi Ta, Mauricio J Reginato, Adrian C Shieh
UNLABELLED: A variety of biophysical forces are altered in the tumor microenvironment (TME) and these forces can influence cancer progression. One such force is interstitial fluid flow (IFF)-the movement of fluid through the tissue matrix. IFF was previously shown to induce invasion of cancer cells, but the activated signaling cascades remain poorly understood. Here, it is demonstrated that IFF induces invasion of ERBB2/HER2-expressing breast cancer cells via activation of phosphoinositide-3-kinase (PI3K)...
April 2015: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/23555168/routine-defunctioning-stoma-after-chemoradiation-and-total-mesorectal-excision-a-single-surgeon-experience
#5
Shao-Chieh Lin, Po-Chuan Chen, Chung-Ta Lee, Hong-Ming Tsai, Peng-Chan Lin, Helen H W Chen, Yuan-Hwa Wu, Bo-Wen Lin, Wen-Pin Su, Jenq-Chang Lee
AIM: To investigate the 10-year results of treating low rectal cancer by a single surgeon in one institution. METHODS: From Oct 1998 to Feb 2009, we prospectively followed a total of 62 patients with cT2-4 low rectal cancer with lower tumor margins measuring at 3 to 6 cm above the anal verge. All patients received neoadjuvant chemoradiation (CRT) for 6 wk. Among them, 85% of the patients received 225 mg/m(2)/d 5-fluorouracil using a portable infusion pump. The whole pelvis received a total dose of 45 Gy of irradiation in 25 fractions over 5 wk...
March 21, 2013: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/12005712/response-to-tilted-magnetic-fields-in-bi-2-sr-2-cacu-2-o-8-with-columnar-defects-evidence-for-transverse-meissner-effect
#6
V Ta Phuoc, E Olive, R De Sousa, A Ruyter, L Ammor, J C Soret
The transverse Meissner effect (TME) in the highly layered superconductor Bi(2)Sr(2)CaCu(2)O(8+y) with columnar defects is investigated by transport measurements. We present evidence for the persistence of the Bose glass phase for H(perpendicular)<H(perpendicular c): (i) the variable-range vortex hopping process crosses over to the half-loop regime; (ii) near H(perpendicular c) the energy barriers vanish linearly with H(perpendicular); (iii) the transition temperature is governed by T(BG)(H(parallel),0)-T(BG)(H(parallel),H(perpendicular)) approximately /H( perpendicular)/(1/nu(perpendicular)) with nu(perpendicular) = 1...
May 6, 2002: Physical Review Letters
https://www.readbyqxmd.com/read/10579410/effects-of-ambient-temperature-on-heat-increment-of-feeding-and-energy-retention-in-growing-broilers-maintained-at-different-food-intakes
#7
K Koh, M G MacLeod
Zero-activity heat production (HP), body temperature (Tb) and energy retention were measured in growing broilers maintained at 5 ambient temperatures (Ta) (14 degrees , 17 degrees , 22 degrees , 27 degrees and 32 degrees C) and at 5 feeding rates (ad libitum intake and 75%, 50%, 25% and 0% (fasting) of ad libitum). Zero-activity HP increased with decreasing Ta and increasing food intake. However, at 14 degrees C, zero-activity HP in birds fed ad libitum and 75% did not show further increase, but those in birds fed less than 75% of ad libitum increased rapidly...
September 1999: British Poultry Science
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