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Preterm, very low birth weight, apnea, patent ductus arteriosus

Mehmet Deliktaş, Hacer Ergin, Aydın Demiray, Hakan Akça, Özmert M A Özdemir, Mehmet Bülent Özdemir
OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain. Caffeine used in the treatment of apnea of prematurity was reported to decrease mechanical ventilation requirement, the frequencies of bronchopulmonary dysplasia, patent ductus arteriosus, cerebral palsy and neurodevelopmental disorders in very low birth weight infants. However, the effect of caffeine on hyperbilirubinemia was not yet clarified...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
Fakhri Navaei, Banafsheh Aliabady, Javad Moghtaderi, Masoud Moghtaderi, Roya Kelishadi
BACKGROUND: The outcome of preterm neonates has been varied in different hospitals and regions in developing countries. This study aimed to determine the mortality, morbidity and survival of neonates weighing 1500 g or less and with gestational age of 30 weeks or less who were admitted to referral neonatal intensive care units (NICUs) of two hospitals in Isfahan city, Iran and to investigate the effect of birth weight, gestational age and Apgar score on infant mortality. METHODS: We studied retrospectively the morbidity, mortality and survival of 194 newborns with a birth weight of </=1500 g and a gestational age of </=30 weeks who had been hospitalized during a 15-month period in NICUs of the two referral hospitals...
August 2010: World Journal of Pediatrics: WJP
Edward F Bell, Ronald G Strauss, John A Widness, Larry T Mahoney, Donald M Mock, Victoria J Seward, Gretchen A Cress, Karen J Johnson, Irma J Kromer, M Bridget Zimmerman
OBJECTIVE: Although many centers have introduced more restrictive transfusion policies for preterm infants in recent years, the benefits and adverse consequences of allowing lower hematocrit levels have not been systematically evaluated. The objective of this study was to determine if restrictive guidelines for red blood cell (RBC) transfusions for preterm infants can reduce the number of transfusions without adverse consequences. DESIGN, SETTING, AND PATIENTS: We enrolled 100 hospitalized preterm infants with birth weights of 500 to 1300 g into a randomized clinical trial comparing 2 levels of hematocrit threshold for RBC transfusion...
June 2005: Pediatrics
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