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Microbiota inflammatory bowel disease

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https://www.readbyqxmd.com/read/28217370/tryptophan-a-gut-microbiota-derived-metabolites-regulating-inflammation
#1
REVIEW
Lucie Etienne-Mesmin, Benoit Chassaing, Andrew T Gewirtz
Inflammatory bowel diseases (IBD), which comprise Crohn's disease and ulcerative colitis, are chronic intestinal disorders with an increased prevalence and incidence over the last decade in many different regions over the world. The etiology of IBD is still not well defined, but evidence suggest that it results from perturbation of the homeostasis between the intestinal microbiota and the mucosal immune system, with the involvement of both genetic and environmental factors. Genome wide association studies, which involve large-scale genome-wide screening of potential polymorphism, have identified several mutations associated with IBD...
February 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28215168/contributions-of-the-interaction-between-dietary-protein-and-gut-microbiota-to-intestinal-health
#2
Ning Ma, Yanan Tian, Yi Wu, Xi Ma
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which give rise to the view that function between the microbiota and protein can proceed in both directions...
February 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28215162/gut-brain-axis-role-of-lipids-in-the-regulation-of-inflammation-pain-and-cns-diseases
#3
Roberto Russo, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli, Antonio Calignano
The human gut is a composite anaerobic environment with a large, diverse and dynamic enteric microbiota, represented by more than 100 trillion microorganisms, including at least 1000 distinct species. The discovery that a different microbial composition can influence behavior and cognition, and in turn the nervous system can indirectly influence enteric microbiota composition, has significantly contributed to establish the well-accepted concept of gut-brain axis. This hypothesis is supported by several evidence showing mutual mechanisms, which involve the vague nerve, the immune system, the hypothalamic-pituitary-adrenal (HPA) axis modulation and the bacteria-derived metabolites...
February 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28211537/ambient-ultrafine-particle-ingestion-alters-gut-microbiota-in-association-with-increased-atherogenic-lipid-metabolites
#4
Rongsong Li, Jieping Yang, Arian Saffari, Jonathan Jacobs, Kyung In Baek, Greg Hough, Muriel H Larauche, Jianguo Ma, Nelson Jen, Nabila Moussaoui, Bill Zhou, Hanul Kang, Srinivasa Reddy, Susanne M Henning, Matthew J Campen, Joseph Pisegna, Zhaoping Li, Alan M Fogelman, Constantinos Sioutas, Mohamad Navab, Tzung K Hsiai
Ambient particulate matter (PM) exposure is associated with atherosclerosis and inflammatory bowel disease. Ultrafine particles (UFP, dp < 0.1-0.2 μm) are redox active components of PM. We hypothesized that orally ingested UFP promoted atherogenic lipid metabolites in both the intestine and plasma via altered gut microbiota composition. Low density lipoprotein receptor-null (Ldlr(-/-)) mice on a high-fat diet were orally administered with vehicle control or UFP (40 μg/mouse/day) for 3 days a week...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197336/embracing-the-gut-microbiota-the-new-frontier-for-inflammatory-and-infectious-diseases
#5
REVIEW
Lieke Wj van den Elsen, Hazel C Poyntz, Laura S Weyrich, Wayne Young, Elizabeth E Forbes-Blom
The gut microbiota provides essential signals for the development and appropriate function of the immune system. Through this critical contribution to immune fitness, the gut microbiota has a key role in health and disease. Recent advances in the technological applications to study microbial communities and their functions have contributed to a rapid increase in host-microbiota research. Although it still remains difficult to define a so-called 'normal' or 'healthy' microbial composition, alterations in the gut microbiota have been shown to influence the susceptibility of the host to different diseases...
January 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28194152/hsp65-producing-lactococcus-lactis-prevents-inflammatory-intestinal-disease-in-mice-by-il-10-and-tlr2-dependent-pathways
#6
Ana Cristina Gomes-Santos, Rafael Pires de Oliveira, Thaís Garcias Moreira, Archimedes Barbosa Castro-Junior, Bernardo Coelho Horta, Luísa Lemos, Leonardo Augusto de Almeida, Rafael Machado Rezende, Denise Carmona Cara, Sérgio Costa Oliveira, Vasco Ariston Carvalho Azevedo, Anderson Miyoshi, Ana Maria Caetano Faria
Heat shock proteins (Hsps) are highly expressed at all sites of inflammation. As they are ubiquitous and immunodominant antigens, these molecules represent good candidates for the therapeutic use of oral tolerance in autoimmune and chronic inflammatory diseases. Evidences from human and animal studies indicate that inflammatory bowel disease (IBD) results from uncontrolled inflammatory responses to intestinal microbiota. Hsps are immunodominant proteins expressed by several immune cells and by commensal bacteria...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28179906/canonical-and-non-canonical-activation-of-nlrp3-inflammasome-at-the-crossroad-between-immune-tolerance-and-intestinal-inflammation
#7
REVIEW
Carolina Pellegrini, Luca Antonioli, Gloria Lopez-Castejon, Corrado Blandizzi, Matteo Fornai
Several lines of evidence point out the relevance of nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome as a pivotal player in regulating the integrity of intestinal homeostasis and shaping innate immune responses during bowel inflammation. Intensive research efforts are being made to achieve an integrated view about the protective/detrimental role of canonical and non-canonical NLRP3 inflammasome activation in the maintenance of intestinal microenvironment integrity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28179509/iga-coated-e-coli-enriched-in-crohn-s-disease-spondyloarthritis-promote-th17-dependent-inflammation
#8
Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G Castellanos, Viola Woo, Fei Teng, Nhan L Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E Diehl, Nadim J Ajami, Joseph F Petrosino, Xi K Zhou, Sergio Schwartzman, Lisa A Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J Scherl, Hsin-Jung Joyce Wu, Kenneth W Simpson, Randy S Longman
Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with active inflammatory bowel disease (IBD) characterized by inflammatory enthesitis, dactylitis, or synovitis of nonaxial joints. However, a mechanistic understanding of the link between intestinal inflammation and SpA has yet to emerge. We evaluated and functionally characterized the fecal microbiome of IBD patients with or without peripheral SpA. Coupling the sorting of immunoglobulin A (IgA)-coated microbiota with 16S ribosomal RNA-based analysis (IgA-seq) revealed a selective enrichment in IgA-coated Escherichia coli in patients with Crohn's disease-associated SpA (CD-SpA) compared to CD alone...
February 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28179109/mechanisms-of-defense-against-products-of-cysteine-catabolism-in-the-nematode-caenorhabditis-elegans
#9
Leonid Livshits, Arijit Kumar Chatterjee, Netanel Karbian, Rachel Abergel, Zohar Abergel, Einav Gross
Cysteine catabolism presents cells with a double-edged sword. On the one hand, cysteine degradation provides cells with essential molecules such as taurine and sulfide. The formation of sulfide in cells is thought to regulate important and diverse physiological processes including blood circulation, synaptic activity and inflammation. On the other hand, the catabolism of cysteine by gut microbiota can release high levels of sulfide that may underlie the development or relapse of ulcerative colitis, an inflammatory bowel disease affecting millions of people worldwide...
February 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28178876/designing-fecal-microbiota-transplant-trials-that-account-for-differences-in-donor-stool-efficacy
#10
Scott W Olesen, Thomas Gurry, Eric J Alm
Fecal microbiota transplantation is a highly effective intervention for patients suffering from recurrent Clostridium difficile, a common hospital-acquired infection. Fecal microbiota transplantation's success as a therapy for C. difficile has inspired interest in performing clinical trials that experiment with fecal microbiota transplantation as a therapy for other conditions like inflammatory bowel disease, obesity, diabetes, and Parkinson's disease. Results from clinical trials that use fecal microbiota transplantation to treat inflammatory bowel disease suggest that, for at least one condition beyond C...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28176667/gut-microbiota-modulation-and-anti-inflammatory-properties-of-dietary-polyphenols-in-ibd-new-and-consolidated-perspectives
#11
Angelo Santino, Aurelia Scarano, Stefania De Santis, Maria De Benedictis, Giovanna Giovinazzo, Marcello Chieppa
BACKGROUND: Polyphenols represent a great variety of compounds occurring in fruits, vegetables and plant-derived products. Dietary polyphenols have been found displaying several biological properties, such as anti-inflammatory, antioxidant and anti-aging activities, cardiovascular and neuro-protection, and reduction of the risk of intestinal diseases. The bio-efficacy of polyphenols is tightly linked to their bioavailability, to structural complexity and composition of food matrix in which they are present...
February 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28176664/role-of-lactic-acid-probiotic-bacteria-in-ibd
#12
Ravichandra Vemuri, Rohit Gundamaraju, Rajaraman Eri
BACKGROUND: IBD is considered as one of the major public health concerns worldwide. The pathophysiology and gut microbial alteration during inflammatory bowel disease (IBD) are still not completely understood. Gut microbiota is implicated in most of the gastro-intestinal (GI) diseases including IBD. From the time of gut microbiota establishment and through aging, it undergoes a lot of changes in the composition. METHODS: In a healthy state, the composition of beneficial microbes in the gut is comparatively higher and due to factors such as malnutrition, use of antibiotics and any underlying diseases allow the colonization and invasion of pathogens...
February 6, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28176047/gastrointestinal-physiology-and-function
#13
Beverley Greenwood-Van Meerveld, Anthony C Johnson, David Grundy
The gastrointestinal (GI) system is responsible for the digestion and absorption of ingested food and liquids. Due to the complexity of the GI tract and the substantial volume of material that could be covered under the scope of GI physiology, this chapter briefly reviews the overall function of the GI tract, and discusses the major factors affecting GI physiology and function, including the intestinal microbiota, chronic stress, inflammation, and aging with a focus on the neural regulation of the GI tract and an emphasis on basic brain-gut interactions that serve to modulate the GI tract...
February 8, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28175257/p788-microbiota-related-disease-activity-and-distribution-in-subgroups-of-inflammatory-bowel-disease
#14
P Ricanek, K Rahul, Y Ber, S Vatn, L Finnby, T Lindahl, D Bergemalm, A Carsten, J Söderholm, J Jahnsen, F Gomollon, J Halfvarson, J Satsangi, C Casen, M H Vatn
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175188/p587-fermentation-capacity-of-gut-microbiota-in-patients-with-inflammatory-bowel-disease-compared-to-healthy-controls
#15
M McGowan, M Kokkorou, M Rebull, Y Koh, D R Gaya, R Hansen, R K Russell, K Gerasimidis
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174738/microgeographic-proteomic-networks-of-the-human-colonic-mucosa-and-their-association-with-inflammatory-bowel-disease
#16
Xiaoxiao Li, James LeBlanc, David Elashoff, Ian McHardy, Maomeng Tong, Bennett Roth, Andrew Ippoliti, Gildardo Barron, Dermot McGovern, Keely McDonald, Rodney Newberry, Thomas Graeber, Steve Horvath, Lee Goodglick, Jonathan Braun
BACKGROUND & AIMS: Interactions between mucosal cell types, environmental stressors, and intestinal microbiota contribute to pathogenesis in inflammatory bowel disease (IBD). Here, we applied metaproteomics of the mucosal-luminal interface to study the disease-related biology of the human colonic mucosa. METHODS: We recruited a discovery cohort of 51 IBD and non-IBD subjects endoscopically sampled by mucosal lavage at 6 colonic regions, and a validation cohort of 38 no-IBD subjects...
September 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28174737/metagenomic-characterization-of-microbial-communities-in-situ-within-the-deeper-layers-of-the-ileum-in-crohn-s-disease
#17
Chandra Sekhar Pedamallu, Ami S Bhatt, Susan Bullman, Sharyle Fowler, Samuel S Freeman, Jacqueline Durand, Joonil Jung, Fujiko Duke, Veronica Manzo, Diana Cai, Ashwin Ananthakrishnan, Akinyemi I Ojesina, Aruna Ramachandran, Dirk Gevers, Ramnik J Xavier, Atul K Bhan, Matthew Meyerson, Vijay Yajnik
BACKGROUND & AIMS: Microbial dysbiosis and aberrant host-microbe interactions in the gut are believed to contribute to the development and progression of Crohn's disease (CD). Microbiome studies in CD typically have focused on microbiota in feces or superficial mucosal layers of the colon because accessing DNA from deeper layers of the bowel is challenging. In this study, we analyzed the deep tissue microbiome in patients who underwent surgical resection of the small intestine. METHODS: Paraffin blocks were obtained from 12 CD patients undergoing ileocecal resection, and healthy ileum samples (inflammatory bowel disease-free controls) were obtained from 12 patients undergoing surgery for right-sided colon cancer...
September 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28174727/microbiota-alterations-in-inflammatory-bowel-diseases-from-correlation-to-causality
#18
EDITORIAL
Benoit Chassaing
No abstract text is available yet for this article.
July 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28172825/p093-dysregulation-of-cellular-vs-humoral-immunity-to-the-intestinal-microbiota-in-inflammatory-bowel-disease
#19
A Noble, L Durant, L Hoyles, A L McCartney, R Man, S P Costello, P Hendy, D Reddi, J Segal, D Lim, M Bolton, A L Hart, S R Carding, S C Knight
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172822/p589-faecal-microbiota-transplantation-for-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#20
S Paramsothy, R Paramsothy, M Kamm, N Kaakoush, H Mitchell, D Rubin, N Castaño-Rodríguez
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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