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Navin Kapur

Navin K Kapur, Michele Esposito
No abstract text is available yet for this article.
October 2016: Catheterization and Cardiovascular Interventions
Kevin J Morine, Vikram Paruchuri, Xiaoying Qiao, Mark Aronovitz, Gordon S Huggins, David DeNofrio, Michael S Kiernan, Richard H Karas, Navin K Kapur
INTRODUCTION: Transient receptor potential (TRP) channels are broadly expressed cation channels that mediate diverse physiological stimuli and include canonical (TRPC), melastatin (TRPM), and vanilloid (TRPV) subtypes. Recent studies have implicated a role for TRPC6 channels as an important component of signaling via the cytokine, transforming growth factor beta 1 (TGFβ1) in right (RV) or left ventricular (LV) failure. Endoglin (Eng) is a transmembrane glycoprotein that promotes TRPC6 expression and TGFβ1 activity...
August 21, 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Natalia Briceno, Navin K Kapur, Divaka Perera
No abstract text is available yet for this article.
September 15, 2016: Heart: Official Journal of the British Cardiac Society
Michele L Esposito, Nimish Shah, Sam Dow, Sandra Kang, Vikram Paruchuri, Richard H Karas, Navin K Kapur
BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and the TandemHeart left ventricular (LV) assist device are increasingly employed as mechanical circulatory support devices during acute LV injury. METHODS: We examined the effects of right atrial to femoral artery (RA-FA; VA-ECMO) bypass versus left atrial to femoral artery (LA-FA; TandemHeart) bypass using a centrifugal pump (Cardiac Assist Inc) on LV hemodynamics in a swine model of acute LV injury...
July 20, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Navin C Nanda, K K Kapur, Poonam Malhotra Kapoor
Simulation allows interactive transthoracic echocardiography (TTE) learning using a virtual three-dimensional model of the heart and may aid in the acquisition of the cognitive and technical skills needed to perform TTE. The ability to link probe manipulation, cardiac anatomy, and echocardiographic images using a simulator has been shown to be an effective model for training anesthesiology residents in transesophageal echocardiography. A proposed alternative to real-time reality patient-based learning is simulation-based training that allows anesthesiologists to learn complex concepts and procedures, especially for specific structures such as aortic valve...
July 2016: Annals of Cardiac Anaesthesia
Nima Aghili, Yousef Bader, Amanda R Vest, Michael S Kiernan, Carey Kimmelstiel, David DeNofrio, Navin K Kapur
No abstract text is available yet for this article.
June 2016: Circulation. Cardiovascular Interventions
Navin K Kapur, David C Zisa
No abstract text is available yet for this article.
March 2016: EuroIntervention
Michael S Kiernan, Kartik S Sundareswaran, Duc Thinh Pham, Navin K Kapur, Naveen L Pereira, Martin Strueber, David J Farrar, David DeNofrio, Joseph G Rogers
BACKGROUND: Left ventricular assist devices (LVADs) improve survival, quality of life (QOL), and functional capacity (FC) among patients with end-stage heart failure. Few data are available regarding characteristics associated with QOL and FC response. METHODS AND RESULTS: Patients enrolled in the Heartmate II clinical trials that were alive with ongoing LVAD support at 6 months were included. QOL response criteria included scoring above the lowest quartile on either the Minnesota Living With Heart Failure Questionnaire or the Kansas City Cardiomyopathy Questionnaire...
October 2016: Journal of Cardiac Failure
Kevin J Morine, Navin K Kapur
The use of percutaneous, non-durable mechanical circulatory support (MCS) for cardiogenic shock (CS) is growing; however, large, randomized clinical trials confirming benefit in this population do not exist. Guidelines and recommendations regarding optimal timing for MCS implementation, patient selection, device selection, and post-implantation management are beginning to emerge. A better understanding of (1) the distinct hemodynamic effects of each device option, (2) the need for early implementation of the appropriate device option for a particular clinical scenario, (3) the definition of non-salvageable CS to help clinicians know when to say "no" to non-durable MCS, and (4) best practices to monitor, wean, and optimize metabolic parameters while using non-durable MCS are required to continue improving clinical outcomes for patients with CS...
January 2016: Current Treatment Options in Cardiovascular Medicine
Lokien X van Nunen, Marko Noc, Navin K Kapur, Manesh R Patel, Divaka Perera, Nico H J Pijls
Intra-aortic balloon pump (IABP) counterpulsation is the most widely used mechanical circulatory support device because of its ease of use, low complication rate, and fast manner of insertion. Its benefit is still subject of debate, and a considerable gap exists between guidelines and clinical practice. Retrospective nonrandomized studies and animal experiments show benefits of IABP therapy. However, recent large randomized trials do not show benefit of IABP therapy, which has led to a downgrading in the guidelines...
February 1, 2016: American Journal of Cardiology
Mark B Anderson, James Goldstein, Carmelo Milano, Lynn D Morris, Robert L Kormos, Jay Bhama, Navin K Kapur, Aditya Bansal, Jose Garcia, Joshua N Baker, Scott Silvestry, William L Holman, Pamela S Douglas, William O'Neill
BACKGROUND: Right ventricular failure (RVF) increases morbidity and mortality. The RECOVER RIGHT study evaluated the safety and efficacy of a novel percutaneous right ventricular assist device, the Impella RP (Abiomed, Danvers, MA), in a prospective, multicenter trial. METHODS: Thirty patients with RVF refractory to medical treatment received the Impella RP device at 15 United States institutions. The study population included 2 cohorts: 18 patients with RVF after left ventricular assist device (LVAD) implantation (Cohort A) and 12 patients with RVF after cardiotomy or myocardial infarction (Cohort B)...
December 2015: Journal of Heart and Lung Transplantation
Kevin J Morine, Vikram Paruchuri, Xiaoying Qiao, Najwa Mohammad, Adam Mcgraw, Adil Yunis, Iris Jaffe, Navin K Kapur
BACKGROUND: Heart failure (HF) involves myocardial fibrosis and dysregulated angiogenesis. OBJECTIVE: We explored whether biomarkers of fibrosis and angiogenesis correlate with HF severity. METHODS: Biomarkers of fibrosis [procollagen types I and III (PIP and P3NP), carboxyterminal-telopeptide of type I collagen (ICTP), matrix metalloproteases (MMP2 and MMP9), tissue inhibitor of MMP1 (TIMP1)]; and angiogenesis [placental growth factor (PGF), vascular endothelial growth factor (VEGF), soluble Fms-like tyrosine kinase-1 (sFlt1)] were measured in 52 HF patients and 19 controls...
2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Kevin J Morine, Michael S Kiernan, Duc Thinh Pham, Vikram Paruchuri, David Denofrio, Navin K Kapur
BACKGROUND: Right ventricular failure (RVF) is a major cause of morbidity and mortality after CF-LVAD implantation. We explored the association of pulmonary artery compliance (PAC), pulmonary artery elastance (PAE), and pulmonary artery pulsatility index (PAPi) in addition to established parameters as preoperative determinants of postoperative RVF after CF-LVAD surgery. METHODS AND RESULTS: We retrospectively reviewed 132 consecutive CF-LVAD implantations at Tufts Medical Center from 2008 to 2013...
February 2016: Journal of Cardiac Failure
Navin K Kapur, Amanda R Vest, Jennifer Cook, Michael S Kiernan
For the majority of patients with heart failure (HF) the management is non-surgical, but for the most advanced subgroup of patients with heart failure and reduced ejection fraction, mechanical circulatory support (MCS) is becoming a more viable treatment option. Heart transplantation is the 'gold standard' for advanced HF therapy, but is limited by donor organ availability. In contrast, MCS utilization has risen exponentially over the past decade. Pump thrombosis is a rare but increasingly recognized cause of morbidity and mortality in this population...
December 2015: Current Problems in Cardiology
Navin K Kapur, Xiaoying Qiao, Vikram Paruchuri, Kevin J Morine, Wajih Syed, Sam Dow, Nimish Shah, Natesa Pandian, Richard H Karas
OBJECTIVES: This study tested the hypothesis that first reducing myocardial work by unloading the left ventricle (LV) with a novel intracorporeal axial flow catheter while delaying coronary reperfusion activates a myocardial protection program and reduces infarct size. BACKGROUND: Ischemic heart disease is a major cause of morbidity and mortality worldwide. Primary myocardial reperfusion remains the gold standard for the treatment of an acute myocardial infarction (AMI); however, ischemia-reperfusion injury contributes to residual myocardial damage and subsequent heart failure...
November 2015: JACC. Heart Failure
Jacob A Doll, E Magnus Ohman, Manesh R Patel, Carmelo A Milano, Joseph G Rogers, David H Wohns, Navin K Kapur, Sunil V Rao
Cardiogenic shock is a common clinical condition with high in-hospital mortality. Early application of appropriate interventions for cardiogenic shock-including medical therapies, revascularization, temporary hemodynamic support devices, and durable mechanical circulatory support-may improve outcomes. The number and complexity of therapies for cardiogenic shock are increasing, making time-dependent decision-making more challenging. A multidisciplinary cardiogenic shock team is recommended to guide the rapid and efficient use of these available treatments...
September 2016: Catheterization and Cardiovascular Interventions
Jenica N Upshaw, Michael S Kiernan, Kevin J Morine, Navin K Kapur, David DeNofrio
Left ventricular assist device (LVAD) thrombosis is associated with high morbidity and mortality because of device malfunction, embolic events, and hemolysis. There remains uncertainty as to whether immediate device exchange versus an initial trial of anticoagulant and antiplatelet therapy is most appropriate in hemodynamically stable patients. We conducted a retrospective analysis of all LVAD implantations at a single center between January 2009 and June 2013 with follow-up through December 2013. Suspected LVAD thrombosis occurred in 20% of patients (N = 25) over a median follow-up of 275 days...
January 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Navin K Kapur, Marwan Jumean, Adel Ghuloom, Nima Aghili, Caitlin Vassallo, Michael S Kiernan, David DeNofrio, Duc Thinh Pham
No abstract text is available yet for this article.
September 2015: Circulation. Heart Failure
Navin K Kapur, Richard H Karas
No abstract text is available yet for this article.
November 21, 2015: European Heart Journal
Charanjit S Rihal, Srihari S Naidu, Michael M Givertz, Wilson Y Szeto, James A Burke, Navin K Kapur, Morton Kern, Kirk N Garratt, James A Goldstein, Vivian Dimas, Thomas Tu
Although historically the intra-aortic balloon pump has been the only mechanical circulatory support device available to clinicians, a number of new devices have become commercially available and have entered clinical practice. These include axial flow pumps, such as Impella(®); left atrial to femoral artery bypass pumps, specifically the TandemHeart; and new devices for institution of extracorporeal membrane oxygenation. These devices differ significantly in their hemodynamic effects, insertion, monitoring, and clinical applicability...
June 2015: Journal of Cardiac Failure
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