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Navin Kapur

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https://www.readbyqxmd.com/read/28600099/integrating-interventional-cardiology-and-heart-failure-management-for-cardiogenic-shock
#1
REVIEW
Navin K Kapur, Carlos D Davila, Marwan F Jumean
Cardiogenic shock remains one of the most common causes of in-hospital death. Recent data have identified an overall increase in patient complexity, with cardiogenic shock in the setting of acute myocardial infarction. The use of percutaneous acute mechanical circulatory support (AMCS) has steadily grown in the past decade. Guidelines and consensus statements addressing proper patient selection, timing of AMCS implantation, device choice, and postimplantation protocol are appearing. The emerging role of interventional heart failure specialists within the heart team includes integration and understanding of advanced hemodynamic and cathether-based therapies, with the goal of improving outcomes...
July 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28580136/acute-mechanical-circulatory-support-for-cardiogenic-shock-the-door-to-support-time
#2
REVIEW
Michele L Esposito, Navin K Kapur
Cardiogenic shock (CS) remains a major cause of in-hospital mortality in the setting of acute myocardial infarction. CS begins as a hemodynamic problem with impaired cardiac output leading to reduced systemic perfusion, increased residual volume within the left and right ventricles, and increased cardiac filling pressures. A critical step towards the development of future algorithms is a clear understanding of the treatment objectives for CS. In this review, we introduce the "door to support" time as an emerging target of therapy to improve outcomes associated with CS, define four key treatment objectives in the management of CS, discuss the importance of early hemodynamic assessment and appropriate selection of acute mechanical circulatory support (AMCS) devices for CS, and introduce a classification scheme that identifies subtypes of CS based on cardiac filling pressures...
2017: F1000Research
https://www.readbyqxmd.com/read/28554716/acute-hemodynamic-effects-of-intra-aortic-balloon-counterpulsation-pumps-in-advanced-heart-failure
#3
Shiva K Annamalai, Lyanne Buiten, Michele L Esposito, Vikram Paruchuri, Andrew Mullin, Catalina Breton, Robert Pedicini, Ryan O'Kelly, Kevin Morine, Benjamin Wessler, Ayan R Patel, Michael S Kiernan, Richard H Karas, Navin K Kapur
BACKGROUND: The utility of intra-aortic balloon counterpulsation pumps (IABPs) in low cardiac output states is unknown and no studies have explored the impact of IABP therapy on ventricular workload in patients with advanced HF. For these reasons, we explored the acute hemodynamic effects of IABP therapy in patients with advanced HF. METHODS: We prospectively studied 10 consecutive patients with Stage D HF referred for IABP placement prior to LVAD surgery and compared to five control patients with preserved left ventricular (LV) ejection fraction (EF) who did not receive IABP therapy...
May 26, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28489331/scai-hfsa-clinical-expert-consensus-document-on-the-use-of-invasive-hemodynamics-for-the-diagnosis-and-management-of-cardiovascular-disease
#4
EDITORIAL
Paul Sorajja, Barry A Borlaug, Vasiliki V Dimas, James C Fang, Paul R Forfia, Michael M Givertz, Navin K Kapur, Morton J Kern, Srihari S Naidu
No abstract text is available yet for this article.
May 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28489324/executive-summary-of-the-scai-hfsa-clinical-expert-consensus-document-on-the-use-of-invasive-hemodynamics-for-the-diagnosis-and-management-of-cardiovascular-disease
#5
Paul Sorajja, Barry A Borlaug, Vivian Dimas, James C Fang, Paul R Forfia, Michael M Givertz, Navin K Kapur, Morton J Kern, Srihari S Naidu
No abstract text is available yet for this article.
May 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28454731/executive-summary-of-the-scai-hfsa-clinical-expert-consensus-document-on-the-use-of-invasive-hemodynamics-for-the-diagnosis-and-management-of-cardiovascular-disease
#6
Michael M Givertz, James C Fang, Paul Sorajja, Vivian Dimas, Paul R Forfia, Navin K Kapur, Morton J Kern, Srihari S Naidu, Barry A Borlaug
No abstract text is available yet for this article.
April 25, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28213819/conditional-knockout-of-activin-like-kinase-1-alk-1-leads-to-heart-failure-without-maladaptive-remodeling
#7
Kevin J Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J Aronovitz, Emily E Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M Blanton, Richard H Karas, S Paul Oh, Navin K Kapur
Activin like kinase-1 (AlK-1) mediates signaling via the transforming growth factor beta (TGFβ) family of ligands. AlK-1 activity promotes endothelial proliferation and migration. Reduced AlK-1 activity is associated with arteriovenous malformations. No studies have examined the effect of global AlK-1 deletion on indices of cardiac remodeling. We hypothesized that reduced levels of AlK-1 promote maladaptive cardiac remodeling. To test this hypothesis, we employed AlK-1 conditional knockout mice (cKO) harboring the ROSA26-CreER knock-in allele, whereby a single dose of intraperitoneal tamoxifen triggered ubiquitous Cre recombinase-mediated excision of floxed AlK-1 alleles...
May 2017: Heart and Vessels
https://www.readbyqxmd.com/read/27970368/tct-196-from-door-to-balloon-to-door-to-unload-a-transcriptomic-analysis-identifies-that-primary-unloading-globally-shifts-gene-expression-and-preserves-mitochondrial-integrity-within-the-infarct-zone-during-the-acute-phase-of-ami
#8
Michele Esposito, Yali Zhang, Gavin Schnitzler, Vikram Paruchuri, Xiaoying Qiao, Shiva Annamalai, Emily Mackey, Kevin Morine, Andrew Mullin, Tobias Rheude, Catalina Breton, Richard Karas, Noam Josephy, Navin Kapur
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970301/tct-135-increased-circulating-plasma-free-hemoglobin-levels-not-lactate-dehydrogenase-levels-identify-hemolysis-among-patients-with-cardiogenic-shock-treated-with-an-impella-micro-axial-flow-catheter
#9
Michele Esposito, Ryan O'Kelly, Nima Aghili, Shiva Annamalai, Anas Hamadeh, Michael Kiernan, Amanda Vest, David DeNofrio, Navin Kapur
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970296/tct-132-utility-of-the-save-score-as-a-predictor-of-survival-in-cardiogenic-shock-requiring-va-ecmo-or-impella-for-acute-mechanical-circulatory-support
#10
Sudeep Kuchibhotla, Michele Esposito, David Zisa, Ryan O'Kelly, Shiva Annamalai, Adel Ghuloom, Leslie Lussier, Catalina Breton, Tobias Rheude, Andrew Mullin, Carey Kimmelstiel, Michael Kiernan, Amanda Vest, Navin Kapur
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970291/tct-126-simultaneous-not-staged-deployment-of-biventricular-micro-axial-flow-impella-catheters-bipella-is-associated-with-improved-survival-for-cardiogenic-shock-involving-biventricular-failure
#11
Navin Kapur, Catalina Breton, Ryan O'Kelly, Michele Esposito, Tobias Rheude, Andrew Mullin, Shiva Annamalai, Mark Grise, Michael Kiernan, Duc Thinh Pham, Mark Anderson, D Lynn Morris
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970284/tct-122-use-of-the-impella-5-0-circulatory-support-device-for-bridge-to-decision-during-acute-decompensation-of-advanced-heart-failure
#12
Shelley Hall, Nir Uriel, Sandra Carey, Michelle Edens, Michele Esposito, Ryan O'Kelly, Shiva Annamalai, Nima Aghili, Sirtaz Adatya, Navin Kapur
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970276/tct-114-comparing-hemodynamic-profiles-and-outcomes-in-cardiogenic-shock-requiring-va-ecmo-or-impella-for-circulatory-support
#13
Michele Esposito, Sudeep Kuchibhotla, David Zisa, Ryan O'Kelly, Shiva Annamalai, Adel Ghuloom, Leslie Lussier, Catalina Breton, Tobias Rheude, Andrew Mullin, Carey Kimmelstiel, Michael Kiernan, Amanda Vest, Navin Kapur
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969583/tct-23-contemporary-trends-in-utilization-of-mechanical-circulatory-support-in-patients-hospitalized-after-out-of-hospital-cardiac-arrest
#14
Nileshkumar Patel, Nish Patel, Gabriel Hernandez, Shilpkumar Arora, Apurva Badheka, Abhishek Deshmukh, Eduardo DeMarchena, Mauricio Cohen, Carlos Alfonso, Deepak Bhatt, Navin Kapur
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27865069/investing-in-our-future-update-on-the-scai-emerging-leader-mentorship-elm-program
#15
Dmitriy N Feldman, Herbert D Aronow, Rajesh V Swaminathan, J Dawn Abbott, Jennifer A Tremmel, Navin K Kapur, John P Breinholt, Anita W Asgar, Duane S Pinto, Thomas M Tu, Kenneth M Rosenfield, Srihari S Naidu
No abstract text is available yet for this article.
November 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27759925/small-acute-mechanical-circulatory-support-pumps-for-small-people
#16
COMMENT
Navin K Kapur, Michele Esposito
No abstract text is available yet for this article.
October 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27614169/endoglin-selectively-modulates-transient-receptor-potential-channel-expression-in-left-and-right-heart-failure
#17
Kevin J Morine, Vikram Paruchuri, Xiaoying Qiao, Mark Aronovitz, Gordon S Huggins, David DeNofrio, Michael S Kiernan, Richard H Karas, Navin K Kapur
INTRODUCTION: Transient receptor potential (TRP) channels are broadly expressed cation channels that mediate diverse physiological stimuli and include canonical (TRPC), melastatin (TRPM), and vanilloid (TRPV) subtypes. Recent studies have implicated a role for TRPC6 channels as an important component of signaling via the cytokine, transforming growth factor beta 1 (TGFβ1) in right (RV) or left ventricular (LV) failure. Endoglin (Eng) is a transmembrane glycoprotein that promotes TRPC6 expression and TGFβ1 activity...
November 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27503999/percutaneous-mechanical-circulatory-support-current-concepts-and-future-directions
#18
Natalia Briceno, Navin K Kapur, Divaka Perera
No abstract text is available yet for this article.
September 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27442859/distinct-effects-of-left-or-right-atrial-cannulation-on-left-ventricular-hemodynamics-in-a-swine-model-of-acute-myocardial-injury
#19
Michele L Esposito, Nimish Shah, Sam Dow, Sandra Kang, Vikram Paruchuri, Richard H Karas, Navin K Kapur
BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and the TandemHeart left ventricular (LV) assist device are increasingly employed as mechanical circulatory support devices during acute LV injury. METHODS: We examined the effects of right atrial to femoral artery (RA-FA; VA-ECMO) bypass versus left atrial to femoral artery (LA-FA; TandemHeart) bypass using a centrifugal pump (Cardiac Assist Inc) on LV hemodynamics in a swine model of acute LV injury...
July 20, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27397455/simulation-for-transthoracic-echocardiography-of-aortic-valve
#20
REVIEW
Navin C Nanda, K K Kapur, Poonam Malhotra Kapoor
Simulation allows interactive transthoracic echocardiography (TTE) learning using a virtual three-dimensional model of the heart and may aid in the acquisition of the cognitive and technical skills needed to perform TTE. The ability to link probe manipulation, cardiac anatomy, and echocardiographic images using a simulator has been shown to be an effective model for training anesthesiology residents in transesophageal echocardiography. A proposed alternative to real-time reality patient-based learning is simulation-based training that allows anesthesiologists to learn complex concepts and procedures, especially for specific structures such as aortic valve...
July 2016: Annals of Cardiac Anaesthesia
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