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Robert Lederman

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https://www.readbyqxmd.com/read/28874164/radiation-free-cmr-diagnostic-heart-catheterization-in-children
#1
Kanishka Ratnayaka, Joshua P Kanter, Anthony Z Faranesh, Elena K Grant, Laura J Olivieri, Russell R Cross, Ileen F Cronin, Karin S Hamann, Adrienne E Campbell-Washburn, Kendall J O'Brien, Toby Rogers, Michael S Hansen, Robert J Lederman
BACKGROUND: Children with heart disease may require repeated X-Ray cardiac catheterization procedures, are more radiosensitive, and more likely to survive to experience oncologic risks of medical radiation. Cardiovascular magnetic resonance (CMR) is radiation-free and offers information about structure, function, and perfusion but not hemodynamics. We intend to perform complete radiation-free diagnostic right heart catheterization entirely using CMR fluoroscopy guidance in an unselected cohort of pediatric patients; we report the feasibility and safety...
September 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28805039/unnatural-milieu-thrombus-after-transcatheter-mitral-valve-replacement
#2
EDITORIAL
Jaffar M Khan, Robert J Lederman
What the article teaches Transcatheter heart valve thrombosis in the mitral position causes increased valve gradients, valve dysfunction, and symptoms, and may be associated with lack of therapeutic anticoagulation. How it will impact practice Anticoagulation with a vitamin K antagonist should be considered in all patients undergoing transcatheter mitral valve replacement. What new research/study would help answer the question posed Efficacy, optimal duration, and safety of anticoagulation therapy, balancing reduced thrombosis against increased bleeding risk, needs to be assessed in larger cohort studies and prospective trials...
August 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28774381/first-in-human-closed-chest-transcatheter-superior-cavopulmonary-anastomosis
#3
Kanishka Ratnayaka, John W Moore, Rodrigo Rios, Robert J Lederman, Sanjeet R Hegde, Howaida G El-Said
BACKGROUND: In the care of patients with congenital heart disease, percutaneous interventional treatments have supplanted many surgical approaches for simple lesions, such as atrial septal defect. By contrast, complex congenital heart defects continue to require open-heart surgery. In single-ventricle patients, a staged approach is employed, which requires multiple open-heart surgeries and significant attendant morbidity and mortality. A nonsurgical transcatheter alternative would be attractive...
August 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28750642/cmr-fluoroscopy-right-heart-catheterization-for-cardiac-output-and-pulmonary-vascular-resistance-results-in-102-patients
#4
Toby Rogers, Kanishka Ratnayaka, Jaffar M Khan, Annette Stine, William H Schenke, Laurie P Grant, Jonathan R Mazal, Elena K Grant, Adrienne Campbell-Washburn, Michael S Hansen, Rajiv Ramasawmy, Daniel A Herzka, Hui Xue, Peter Kellman, Anthony Z Faranesh, Robert J Lederman
BACKGROUND: Quantification of cardiac output and pulmonary vascular resistance (PVR) are critical components of invasive hemodynamic assessment, and can be measured concurrently with pressures using phase contrast CMR flow during real-time CMR guided cardiac catheterization. METHODS: One hundred two consecutive patients underwent CMR fluoroscopy guided right heart catheterization (RHC) with simultaneous measurement of pressure, cardiac output and pulmonary vascular resistance using CMR flow and the Fick principle for comparison...
July 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28734716/short-term-clinical-outcome-of-an-anatomic-short-stem-humeral-component-in-total-shoulder-arthroplasty
#5
Anthony A Romeo, Robert J Thorsness, Shelby A Sumner, Reuben Gobezie, Evan S Lederman, Patrick J Denard
BACKGROUND: Short-stem press-fit humeral components have recently been developed in an effort to preserve bone in total shoulder arthroplasty (TSA), but few studies have reported outcomes of these devices. The purpose of this study was to evaluate the short-term clinical outcomes of an anatomic short-stem humeral component in TSA. We hypothesized that the implant would lead to significant functional improvement with low rates of radiographic loosening. METHODS: A multicenter retrospective review was performed of TSAs using an anatomic short-stem humeral component (Apex; Arthrex, Inc...
July 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28692969/an-mr-based-model-for-cardio-respiratory-motion-compensation-of-overlays-in-x-ray-fluoroscopy
#6
Peter Fischer, Anthony Faranesh, Thomas Pohl, Andreas Maier, Toby Rogers, Kanishka Ratnayaka, Robert Lederman, Joachim Hornegger
In X-ray fluoroscopy, static overlays are used to visualize soft tissue. We propose a system for cardiac and respiratory motion compensation of these overlays. It consists of a 3-D motion model created from real-time MR imaging. Multiple sagittal slices are acquired and retrospectively stacked to consistent 3-D volumes. Slice stacking considers cardiac information derived from the ECG and respiratory information extracted from the images. Additionally, temporal smoothness of the stacking is enhanced. Motion is estimated from the MR volumes using deformable 3-D/3-D registration...
July 4, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28645230/implementation-in-action-how-australian-exercise-physiologists-approach-exercise-prescription-for-people-with-mental-illness
#7
Robert Stanton, Simon Rosenbaum, Oscar Lederman, Brenda Happell
BACKGROUND: Accredited Exercise Physiologists (AEPs) are trained to deliver exercise and physical activity interventions for people with chronic and complex health conditions including those with mental illness. However, their views on exercise for mental illness, their exercise prescription practices, and need for further training are unknown. AIMS: To examine the way in which Australian AEPs prescribe exercise for people with mental illness. METHODS: Eighty-one AEPs (33...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28618274/the-relationship-between-birth-and-placental-weights-changes-with-placental-size
#8
Carolyn M Salafia, Beata Dygulska, Gabriela Perez-Avilan, Rebecca Schmitt, Drucilla J Roberts, Xilu Ma, Dawn P Misra, Alana Devine Dunn, Sam Ngu, Hussam Inany, Nayaab Khawar, Giashuddin Shah, Pramod Narula, Sanford Lederman
No abstract text is available yet for this article.
June 12, 2017: Early Human Development
https://www.readbyqxmd.com/read/28585448/embedding-exercise-interventions-as-routine-mental-health-care-implementation-strategies-in-residential-inpatient-and-community-settings
#9
Oscar Lederman, Shuichi Suetani, Robert Stanton, Justin Chapman, Nicole Korman, Simon Rosenbaum, Philip B Ward, Dan Siskind
OBJECTIVES: Evaluation of physical activity (PA) programs among populations with severe mental illness (SMI) has predominately focused on efficacy and therapeutic benefits. There is now strong evidence to support the benefits of PA in people with SMI. What remains is a gap in the implementation of pragmatic and sustainable PA interventions in mental-health settings. The current paper provides examples of interventions that have been successfully implemented in Australian settings, identifies key components of successful PA interventions and outlines practical strategies that can assist with widespread implementation of PA interventions in mental-health settings...
May 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28471059/long-or-redundant-leaflet-complicating-transcatheter-mitral-valve-replacement-case-vignettes-that-advocate-for-removal-or-reduction-of-the-anterior-mitral-leaflet
#10
Adam B Greenbaum, Jose F Condado, Marvin Eng, Stamatios Lerakis, Dee Dee Wang, Dennis W Kim, Robert J Lederman, Gaetano Paone, William W O Neill, Vinod H Thourani, Vasilis C Babaliaros
Transcatheter mitral valve replacement (TMVR) procedures can be an alternative to surgical valve replacement for high surgical risk patients with bioprosthetic mitral valves, annuloplasty rings, or severe mitral annular calcification (MAC). TMVR can trigger acute left ventricular outflow tract (LVOT) obstruction from permanent displacement of the native anterior mitral leaflet toward the left ventricular septum, more often among patients undergoing valve-in-ring and valve-in-MAC procedures. Although acute LVOT obstruction is well described in the literature, there are important additional complications of TMVR related to the length and/or redundancy of the anterior mitral valve that have been recognized after mitral valve surgery and have not been previously reported in the setting of TMVR...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28427597/intentional-percutaneous-laceration-of%C3%A2-the%C3%A2-anterior-mitral-leaflet-to-prevent%C3%A2-outflow%C3%A2-obstruction-during-transcatheter-mitral-valve-replacement-first-in-human%C3%A2-experience
#11
Vasilis C Babaliaros, Adam B Greenbaum, Jaffar M Khan, Toby Rogers, Dee Dee Wang, Marvin H Eng, William W O'Neill, Gaetano Paone, Vinod H Thourani, Stamatios Lerakis, Dennis W Kim, Marcus Y Chen, Robert J Lederman
OBJECTIVES: This study sought to use a new catheter technique to split the anterior mitral valve leaflet (AML) and prevent iatrogenic left ventricular outflow tract (LVOT) obstruction immediately before transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a life-threatening complication of TMVR, caused by septal displacement of the AML. METHODS: The procedure was used in patients with severe mitral valve disease and prohibitive surgical risk...
April 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28335897/mitral-loop-cerclage-annuloplasty-for-secondary-mitral-regurgitation-first-human-results
#12
Yong-Hyun Park, Min-Ku Chon, Robert J Lederman, Si-Chan Sung, Hyung-Gon Je, Ki-Seok Choo, Sang-Hyun Lee, Eun-Seok Shin, Jeong-Su Kim, Ki-Won Hwang, Soo-Yong Lee, Kook-Jin Chun, Cheol-Min Kim, June-Hong Kim
OBJECTIVES: This is an early feasibility clinical test of mitral loop cerclage annuloplasty to treat secondary mitral valve regurgitation. BACKGROUND: Secondary mitral regurgitation is characterized by cardiomyopathy, mitral annular enlargement, and leaflet traction contributing to malcoaptation. Transcatheter mitral loop cerclage applies circumferential compression to the mitral annulus by creating a loop through the coronary sinus across the interventricular septum, protecting entrapped coronary arteries from compression, and interactive annular reduction under echocardiographic guidance...
March 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28331526/impaired-human-immunodeficiency-virus-type-1-replicative-fitness-in-atypical-viremic-non-progressor-individuals
#13
Jan Weber, Richard M Gibson, Lenka Sácká, Dmytro Strunin, Jan Hodek, Jitka Weberová, Marcela Pávová, David J Alouani, Robert Asaad, Benigno Rodriguez, Michael M Lederman, Miguel E Quiñones-Mateu
BACKGROUND: Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals-termed viremic non-progressors (VNP) or controllers-do not seem to progress to AIDS, maintaining high CD4(+) T cell counts despite high levels of viremia for many years. Several studies have evaluated multiple host factors, including immune activation, trying to elucidate the atypical HIV-1 disease progression in these patients; however, limited work has been done to characterize viral factors in viremic controllers...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28320417/impaired-human-immunodeficiency-virus-type-1-replicative-fitness-in-atypical-viremic-non-progressor-individuals
#14
Jan Weber, Richard M Gibson, Lenka Sácká, Dmytro Strunin, Jan Hodek, Jitka Weberová, Marcela Pávová, David J Alouani, Robert Asaad, Benigno Rodriguez, Michael M Lederman, Miguel E Quiñones-Mateu
BACKGROUND: Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals-termed viremic non-progressors (VNP) or controllers-do not seem to progress to AIDS, maintaining high CD4(+) T cell counts despite high levels of viremia for many years. Several studies have evaluated multiple host factors, including immune activation, trying to elucidate the atypical HIV-1 disease progression in these patients; however, limited work has been done to characterize viral factors in viremic controllers...
March 20, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28089873/patterns-of-immune-development-in-urban-preschoolers-with-recurrent-wheeze-and-or-atopy
#15
James E Gern, Agustin Calatroni, Katy F Jaffee, Henry Lynn, Amy Dresen, William W Cruikshank, Howard M Lederman, Hugh A Sampson, Wayne Shreffler, Leonard B Bacharier, Peter J Gergen, Diane R Gold, Meyer Kattan, George T O'Connor, Megan T Sandel, Robert A Wood, Gordon R Bloomberg
BACKGROUND: Disadvantaged urban children have high rates of allergic diseases and wheezing, which are diseases associated with type 2-biased immunity. OBJECTIVE: We sought to determine whether environmental exposures in early life influence cytokine responses that affect the development of recurrent wheezing illnesses and allergic sensitization. METHODS: A birth cohort of 560 urban families was recruited from neighborhoods with high rates of poverty, and 467 (83%) children were followed until 3 years of age...
September 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28057275/anatomic-suitability-for-transcaval-access%C3%A2-based-on-computed-tomography
#16
REVIEW
Robert J Lederman, Adam B Greenbaum, Toby Rogers, Jaffar M Khan, Melissa Fusari, Marcus Y Chen
Transcaval access has been used successfully for over 200 transcatheter aortic valve replacements, large-bore percutaneous left ventricular assist devices, and thoracic endovascular aortic aneurysm repairs. This review teaches how to plan transcaval access and closure based on computed tomography. The main planning goals are to: 1) identify calcium-free crossing targets in the abdominal aorta along with optimal fluoroscopic projection angles and level with respect to lumbar vertebrae; 2) identify obstacles such as interposed bowel or pedunculated aortic atheroma; 3) plan covered stent bailout; and 4) identify jeopardized vascular branches such as renal arteries that might be obstructed by bailout covered stents if employed...
January 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27989885/transcaval-access-and-closure-for-transcatheter-aortic-valve-replacement-a%C3%A2-prospective-investigation
#17
MULTICENTER STUDY
Adam B Greenbaum, Vasilis C Babaliaros, Marcus Y Chen, Annette M Stine, Toby Rogers, William W O'Neill, Gaetano Paone, Vinod H Thourani, Kamran I Muhammad, Robert A Leonardi, Stephen Ramee, James F Troendle, Robert J Lederman
BACKGROUND: Transcaval access may enable fully percutaneous transcatheter aortic valve replacement (TAVR) without the hazards and discomfort of transthoracic (transapical or transaortic) access. OBJECTIVES: The authors performed a prospective, independently adjudicated, multicenter, single-arm trial of transcaval access for TAVR in patients who were ineligible for femoral artery access and had high or prohibitive risk of complications from transthoracic access...
February 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970020/tct-642-intentional-laceration-of-the-anterior-mitral-valve-leaflet-to-prevent-left-ventricular-outflow-tract-obstruction-lampoon-during-transcatheter-mitral-valve-implantation-preclinical-findings
#18
Jaffar Khan, Toby Rogers, Anthony Faranesh, Adam Greenbaum, Vasilis Babaliaros, Marcus Chen, Robert Lederman
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27940959/exercise-magnetic-resonance-imaging-is-a-gas
#19
EDITORIAL
Toby Rogers, Robert J Lederman
No abstract text is available yet for this article.
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27631028/real-time-magnetic-resonance-imaging-guidance-improves-the-diagnostic-yield-of-endomyocardial-biopsy
#20
Toby Rogers, Kanishka Ratnayaka, Parag Karmarkar, Adrienne E Campbell-Washburn, William H Schenke, Jonathan R Mazal, Ozgur Kocaturk, Anthony Z Faranesh, Robert J Lederman
BACKGROUND: Diagnostic yield of endomyocardial biopsy is low, particularly in disease that affects the myocardium in a non-uniform distribution. We hypothesized that real-time MRI guidance could improve the yield through targeted biopsy of focal myocardial pathology. METHODS: An animal model of focal myocardial pathology was created by infusing 3mL of fluorescent microspheres (NuFlow Hydrocoat, 15μm diameter, 5 million spheres/mL) followed by 2mL of 100% ethanol to a branch coronary artery...
August 2016: JACC. Basic to Translational Science
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