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Robert Lederman

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https://www.readbyqxmd.com/read/27631028/real-time-magnetic-resonance-imaging-guidance-improves-the-diagnostic-yield-of-endomyocardial-biopsy
#1
Toby Rogers, Kanishka Ratnayaka, Parag Karmarkar, Adrienne E Campbell-Washburn, William H Schenke, Jonathan R Mazal, Ozgur Kocaturk, Anthony Z Faranesh, Robert J Lederman
BACKGROUND: Diagnostic yield of endomyocardial biopsy is low, particularly in disease that affects the myocardium in a non-uniform distribution. We hypothesized that real-time MRI guidance could improve the yield through targeted biopsy of focal myocardial pathology. METHODS: An animal model of focal myocardial pathology was created by infusing 3mL of fluorescent microspheres (NuFlow Hydrocoat, 15μm diameter, 5 million spheres/mL) followed by 2mL of 100% ethanol to a branch coronary artery...
August 2016: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/27609260/intentional-laceration-of-the-anterior-mitral-valve-leaflet-to-prevent-left-ventricular-outflow-tract-obstruction-during-transcatheter-mitral%C3%A2-valve-replacement-pre-clinical-findings
#2
Jaffar M Khan, Toby Rogers, William H Schenke, Jonathan R Mazal, Anthony Z Faranesh, Adam B Greenbaum, Vasilis C Babaliaros, Marcus Y Chen, Robert J Lederman
OBJECTIVES: The authors propose a novel transcatheter transection of the anterior mitral leaflet to prevent iatrogenic left ventricular outflow tract (LVOT) obstruction during transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a life-threatening complication of TMVR caused by septal displacement of the anterior mitral leaflet. METHODS: In vivo procedures in swine were guided by biplane x-ray fluoroscopy and intracardiac echocardiography...
September 12, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27390230/x-ray-fused-with-magnetic-resonance-imaging-to-guide-endomyocardial-biopsy-of-a-right-ventricular-mass
#3
Delaney McGuirt, Jonathan Mazal, Toby Rogers, Anthony Z Faranesh, William Schenke, Annette Stine, Laurie Grant, Robert J Lederman
BACKGROUND: A patient with a history of cancer in remission and congestive heart failure with no acute symptoms presented for a follow-up echocardiogram. The scan revealed a new echodense mass filling his right ventricular apex. An endomyocardial biopsy guided by x-ray fused with magnetic resonance (MR) imaging (XFM) was performed. This case report outlines the steps of XFM image preparation involving MR image acquisition, processing, and coregistration with x-ray fluoroscopy. DISCUSSION: In cases of focal pathology or cardiac masses, endomyocardial biopsy can be challenging because x-ray fluoroscopy guidance offers limited visualization of soft-tissue structures...
July 2016: Radiologic Technology
https://www.readbyqxmd.com/read/27322062/il-15-promotes-activation-and-expansion-of-cd8-t-cells-in-hiv-1-infection
#4
Souheil-Antoine Younes, Michael L Freeman, Joseph C Mudd, Carey L Shive, Arnold Reynaldi, Soumya Panigrahi, Jacob D Estes, Claire Deleage, Carissa Lucero, Jodi Anderson, Timothy W Schacker, Miles P Davenport, Joseph M McCune, Peter W Hunt, Sulggi A Lee, Sergio Serrano-Villar, Robert L Debernardo, Jeffrey M Jacobson, David H Canaday, Rafick-Pierre Sekaly, Benigno Rodriguez, Scott F Sieg, Michael M Lederman
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased risk of morbidity and mortality. Here, we identified a bystander mechanism that promotes CD8 T cell activation and expansion in untreated HIV-1-infected patients. Compared with healthy controls, untreated HIV-1-infected patients have an increased population of proliferating, granzyme B+, CD8+ T cells in circulation. Vβ expression and deep sequencing of CDR3 revealed that in untreated HIV-1 infection, cycling memory CD8 T cells possess a broad T cell repertoire that reflects the repertoire of the resting population...
July 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27209112/predicting-lvot-obstruction-after-tmvr
#5
Dee Dee Wang, Marvin Eng, Adam Greenbaum, Eric Myers, Michael Forbes, Milan Pantelic, Thomas Song, Christina Nelson, George Divine, Andrew Taylor, Janet Wyman, Mayra Guerrero, Robert J Lederman, Gaetano Paone, William O'Neill
No abstract text is available yet for this article.
November 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27191978/responsiveness-to-il-7-but-not-to-ifn-%C3%AE-is-diminished-in-cd4-t-cells-from-treated-hiv-infected-patients-who-experience-poor-cd4-t-cell-recovery
#6
Thao P Nguyen, Supriya Shukla, Robert Asaad, Michael L Freeman, Michael M Lederman, Clifford V Harding, Scott F Sieg
OBJECTIVE: To assess CD4 T-cell responsiveness to IL-7 and IFN-α in HIV-infected patients who experience poor recovery of CD4 T-cell counts during therapy (immune failure patients). DESIGN: Responses to IL-7 and IFN-α were compared between HIV-infected immune failure (CD4 cell counts <379 cells/μl) patients and immune success (CD4 cell counts >500 cells/μl) as well as healthy control patients. METHODS: Flow cytometry was used to assess peripheral blood mononuclear cells for IL-7-induced proliferation, CD25 expression, and signaling (signal transducer and activator of transcription 5 phosphorylation and Akt phosphorylation) in CD4 T cells...
August 24, 2016: AIDS
https://www.readbyqxmd.com/read/27130784/a-prospective-multicenter-study-to-evaluate-clinical-and-radiographic-outcomes-in-primary-rotator-cuff-repair-reinforced-with-a-xenograft-dermal-matrix
#7
Evan S Lederman, Alison P Toth, Gregory P Nicholson, Robert J Nowinski, George K Bal, Gerald R Williams, Joseph P Iannotti
BACKGROUND: Minimal information is currently available on the outcome of rotator cuff repair reinforced with an extracellular matrix (ECM) graft. Therefore, the purpose of this study was to determine the clinical and radiographic outcome of repair of large rotator cuff tears with ECM graft reinforcement. METHODS: This was a prospective study of 61 shoulders with large repairable rotator cuff tears (3 to 5 cm). The rotator cuff tears were surgically repaired and reinforced with a xenograft ECM graft...
April 26, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27085581/magnetic-resonance-imaging-guided-transcatheter-cavopulmonary-shunt
#8
Kanishka Ratnayaka, Toby Rogers, William H Schenke, Jonathan R Mazal, Marcus Y Chen, Merdim Sonmez, Michael S Hansen, Ozgur Kocaturk, Anthony Z Faranesh, Robert J Lederman
OBJECTIVES: The aim of this study was to test the hypothesis that real-time magnetic resonance imaging (MRI) would enable closed-chest percutaneous cavopulmonary anastomosis and shunt by facilitating needle guidance along a curvilinear trajectory, around critical structures, and between a superior vena cava "donor" vessel and a pulmonary artery "target." BACKGROUND: Children with single-ventricle physiology require multiple open heart operations for palliation, including sternotomies and cardiopulmonary bypass...
May 9, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27053637/transcatheter-myocardial-needle-chemoablation-during-real-time-magnetic-resonance-imaging-a-new-approach-to-ablation-therapy-for-rhythm-disorders
#9
Toby Rogers, Srijoy Mahapatra, Steven Kim, Michael A Eckhaus, William H Schenke, Jonathan R Mazal, Adrienne Campbell-Washburn, Merdim Sonmez, Anthony Z Faranesh, Kanishka Ratnayaka, Robert J Lederman
BACKGROUND: Radiofrequency ablation for ventricular arrhythmias is limited by inability to visualize tissue destruction, by reversible conduction block resulting from edema surrounding lesions, and by insufficient lesion depth. We hypothesized that transcatheter needle injection of caustic agents doped with gadolinium contrast under real-time magnetic resonance imaging (MRI) could achieve deep, targeted, and irreversible myocardial ablation, which would be immediately visible. METHODS AND RESULTS: Under real-time MRI guidance, ethanol or acetic acid was injected into the myocardium of 8 swine using MRI-conspicuous needle catheters...
April 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/26912471/consensus-statement-on-the-role-of-accredited-exercise-physiologists-within-the-treatment-of-mental-disorders-a-guide-for-mental-health-professionals
#10
Oscar Lederman, Kristine Grainger, Robert Stanton, Angela Douglas, Kirrily Gould, Amy Perram, Rishi Baldeo, Theodora Fokas, Fiona Nauman, Amanda Semaan, Jude Hewavasam, Louise Pontin, Simon Rosenbaum
OBJECTIVE: The aim is to identify the role and scope of Accredited Exercise Physiologist (AEP) services in the mental health sector and to provide insight as to how AEPs can contribute to the multidisciplinary mental health team. METHODS: A modified Delphi approach was utilised. Thirteen AEPs with experience in mental health contributed to the iterative development of a national consensus statement. Six mental health professionals with expertise in psychiatry, mental health nursing, general practice and mental health research participated in the review process...
August 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/26721838/interventional-cardiovascular-mr-role-of-the-interventional-mr-technologist
#11
Jonathan R Mazal, Toby Rogers, William H Schenke, Anthony Z Faranesh, Michael Hansen, Kendall O'Brien, Kanishka Ratnayaka, Robert J Lederman
Interventional-cardiovascular magnetic resonance (iCMR) is a promising clinical tool for adults and children who need a comprehensive hemodynamic catheterization of the heart. Magnetic resonance (MR) imaging-guided cardiac catheterization offers radiation-free examination with increased soft tissue contrast and unconstrained imaging planes for catheter guidance. The interventional MR technologist plays an important role in the care of patients undergoing such procedures. It is therefore helpful for technologists to understand the unique iCMR preprocedural preparation, procedural and imaging workflows, and management of emergencies...
January 2016: Radiologic Technology
https://www.readbyqxmd.com/read/26695490/positive-contrast-spiral-imaging-for-visualization-of-commercial-nitinol-guidewires-with-reduced-heating
#12
Adrienne E Campbell-Washburn, Toby Rogers, Burcu Basar, Merdim Sonmez, Ozgur Kocaturk, Robert J Lederman, Michael S Hansen, Anthony Z Faranesh
BACKGROUND: CMR-guidance has the potential to improve tissue visualization during cardiovascular catheterization procedures and to reduce ionizing radiation exposure, but a lack of commercially available CMR guidewires limits widespread adoption. Standard metallic guidewires are considered to be unsafe in CMR due to risks of RF-induced heating. Here, we propose the use of RF-efficient gradient echo (GRE) spiral imaging for reduced guidewire heating (low flip angle, long readout), in combination with positive contrast for guidewire visualization...
December 22, 2015: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/26663396/altered-maturation-status-and-possible-immune-exhaustion-of-cd8-t-lymphocytes-in-the-peripheral-blood-of-patients-presenting-with-acute-coronary-syndromes
#13
David A Zidar, Joseph C Mudd, Steven Juchnowski, Joao P Lopes, Sara Sparks, Samantha S Park, Masakazu Ishikawa, Robyn Osborne, Jeffrey B Washam, Cliburn Chan, Nicholas T Funderburg, Adeyinka Owoyele, Mohamad A Alaiti, Myttle Mayuga, Carl Orringer, Marco A Costa, Daniel I Simon, Curtis Tatsuoka, Robert M Califf, L Kristin Newby, Michael M Lederman, Kent J Weinhold
OBJECTIVE: Inflammation in response to oxidized lipoproteins is thought to play a key role in acute coronary syndromes (ACS), but the pattern of immune activation has not been fully characterized. We sought to perform detailed phenotypic and functional analysis of CD8 T lymphocytes from patients presenting with ACS to determine activation patterns and potential immunologic correlates of ACS. APPROACH AND RESULTS: We used polychromatic flow cytometry to analyze the cytokine production profiles of naïve, effector, and memory CD8 T cells in patients with ACS compared with control subjects with stable coronary artery disease...
February 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/26620420/segmented-nitinol-guidewires-with-stiffness-matched-connectors-for-cardiovascular-magnetic-resonance-catheterization-preserved-mechanical-performance-and-freedom-from-heating
#14
COMPARATIVE STUDY
Burcu Basar, Toby Rogers, Kanishka Ratnayaka, Adrienne E Campbell-Washburn, Jonathan R Mazal, William H Schenke, Merdim Sonmez, Anthony Z Faranesh, Robert J Lederman, Ozgur Kocaturk
BACKGROUND: Conventional guidewires are not suitable for use during cardiovascular magnetic resonance (CMR) catheterization. They employ metallic shafts for mechanical performance, but which are conductors subject to radiofrequency (RF) induced heating. To date, non-metallic CMR guidewire designs have provided inadequate mechanical support, trackability, and torquability. We propose a metallic guidewire for CMR that is by design intrinsically safe and that retains mechanical performance of commercial guidewires...
November 30, 2015: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/26618198/intentional-right-atrial-exit-and-carbon-dioxide-insufflation-to-facilitate-subxiphoid-needle-entry-into-the-empty-pericardial-space-first-human-experience
#15
Adam B Greenbaum, Toby Rogers, Gaetano Paone, Shawn E Flynn, Mayra E Guerrero, William W O'Neill, Robert J Lederman
OBJECTIVES: The purpose of this study was to test whether a microcatheter can safely be advanced across the right atrial appendage to access the pericardium and then withdrawn despite subsequent high-intensity anticoagulation. We also tested whether transatrial pericardial insufflation of carbon dioxide (CO2) would enhance the safety of subxiphoid needle access to the empty pericardium by separating the heart from the anterior pericardium. BACKGROUND: Subxiphoid needle access to the empty pericardium, required for left atrial suture ligation and epicardial ablation for rhythm disorders, risks myocardial or coronary laceration...
October 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26499283/magnetic-resonance-sequences-and-rapid-acquisition-for-mr-guided-interventions
#16
REVIEW
Adrienne E Campbell-Washburn, Anthony Z Faranesh, Robert J Lederman, Michael S Hansen
Interventional MR uses rapid imaging to guide diagnostic and therapeutic procedures. One of the attractions of MR-guidance is the abundance of inherent contrast mechanisms available. Dynamic procedural guidance with real-time imaging has pushed the limits of MR technology, demanding rapid acquisition and reconstruction paired with interactive control and device visualization. This article reviews the technical aspects of real-time MR sequences that enable MR-guided interventions.
November 2015: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/26438770/image-fusion-guided-device-closure-of-left-ventricle-to-right-atrium-shunt
#17
Elena K Grant, Anthony Z Faranesh, Russell R Cross, Laura J Olivieri, Karin S Hamann, Kendall J O'Brien, Michael S Hansen, Mary T Donofrio, Robert J Lederman, Kanishka Ratnayaka, Michael C Slack
No abstract text is available yet for this article.
October 6, 2015: Circulation
https://www.readbyqxmd.com/read/26408210/transcaval-aortic-access-for-percutaneous-thoracic-aortic-aneurysm-repair-initial-human-experience
#18
Andre Uflacker, Scott Lim, Michael Ragosta, Ziv J Haskal, Robert J Lederman, John Kern, Gilbert Upchurch, Timothy Huber, John F Angle, Gorav Ailawadi
Transcaval aortic access has been used for deployment of transcatheter aortic valves in patients in whom conventional arterial approaches are not feasible. The present report describes its use for thoracic endovascular aortic repair (TEVAR) in a 61-year-old man with a descending thoracic aneurysm. Transcaval access was performed in lieu of a surgical iliac conduit in view of small atherosclerotic pelvic arteries. TEVAR was successfully performed, followed by intervascular tract occlusion with the use of a ventricular septal occluder...
October 2015: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/26356244/how-to-perform-transcaval-access-and-closure-for-transcatheter-aortic-valve-implantation
#19
REVIEW
Robert J Lederman, Vasilis C Babaliaros, Adam B Greenbaum
Transcaval, or caval-aortic, access is a promising approach for fully percutaneous transcatheter aortic valve implantation in patients without good conventional access options. This tutorial review provides step-by-step guidance to planning and executing the procedure, along with approaches to remedy complications.
December 1, 2015: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/26205455/lost-in-translation
#20
EDITORIAL
Spencer B King, Robert J Lederman
No abstract text is available yet for this article.
July 2015: JACC. Cardiovascular Interventions
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