keyword
https://read.qxmd.com/read/38535779/screening-tlr4-binding-peptide-from-naja-atra-venom-glands-based-on-phage-display
#21
JOURNAL ARTICLE
Runhan Li, Yezhong Tang, Zening Chen, Yang Liu
Toll-like receptor 4 (TLR4) is a crucial inflammatory signaling pathway that can serve as a potential treatment target for various disorders. A number of inhibitors have been developed for the TLR4 pathway, and although no inhibitors have been approved for clinical use, most have been screened against the TLR4-MD2 conformation. The venom gland is the organ of venomous snakes that secretes substances that are toxic to other animals. The level of gene transcription in venom glands is different from that in other tissues, includes a large number of biologically active ingredients, and is an important natural resource for the development of new drugs...
February 24, 2024: Toxins
https://read.qxmd.com/read/38535599/alterations-in-n-glycosylation-of-hcv-e2-protein-in-children-patients-with-ifn-rbv-therapy-failure
#22
JOURNAL ARTICLE
Karolina Zimmer, Alicja M Chmielewska, Paulina Jackowiak, Marek Figlerowicz, Krystyna Bienkowska-Szewczyk
The glycosylation of viral envelope proteins plays an important role in virus biology and the immune response of the host to infection. Hepatitis C virus (HCV) envelope proteins E1 and E2, key players in virus entry and spread, are highly N-glycosylated and possess 4 (5 in certain genotypes) to 11 conserved glycosylation sites, respectively. Many published results based on recombinant proteins indicate that the glycan shield can mask the epitopes targeted by neutralizing antibodies. Glycan shifting within the conserved linear E2 region (412-423) could be one of the escape strategies used by HCV...
March 15, 2024: Pathogens
https://read.qxmd.com/read/38535531/the-intricate-interplay-between-apobec3-proteins-and-dna-tumour-viruses
#23
REVIEW
Nika Lovšin, Bhavani Gangupam, Martina Bergant Marušič
APOBEC3 proteins are cytidine deaminases that play a crucial role in the innate immune response against viruses, including DNA viruses. Their main mechanism for restricting viral replication is the deamination of cytosine to uracil in viral DNA during replication. This process leads to hypermutation of the viral genome, resulting in loss of viral fitness and, in many cases, inactivation of the virus. APOBEC3 proteins inhibit the replication of a number of DNA tumour viruses, including herpesviruses, papillomaviruses and hepadnaviruses...
February 20, 2024: Pathogens
https://read.qxmd.com/read/38535468/induction-of-autophagy-by-extract-from-corydalis-heterocarpa-for-skin-anti-aging
#24
JOURNAL ARTICLE
Kyeong Eun Yang, Soo-Bin Nam, Ga-Eun Lee, Gabsik Yang, Mee-Hyun Lee, Geul Bang, Jung Hoon Choi, Yong-Yeon Cho, Cheol-Jung Lee
The extracts of Corydalis heterocarpa , a salt-tolerant plant, exhibit diverse physiological properties, including anti-inflammatory, anticancer, and antiadipogenic effects. However, the anti-aging effects of C. heterocarpa extract (CHE) on human skin cells have not yet been investigated. In the present study, we determined that CHE inhibited senescence-associated β-galactosidase (SA-β-gal)-stained senescent human dermal fibroblasts (HDFs). Furthermore, CHE markedly suppressed the expression of major regulatory proteins involved in senescence, including p53, p21, and caveolin-1...
March 8, 2024: Marine Drugs
https://read.qxmd.com/read/38535466/effects-of-polymannuronic-acid-on-the-intestinal-microbiota-in-mice-after-long-term-intragastric-administration
#25
JOURNAL ARTICLE
E Zhang, Qiang Wei, Xia Li, Shuliang Song
Polymannuronic acid (PM) is an alginate oligosaccharide derived from brown algae with a characterized structure and excellent biological activities. Herein, mice were given different doses of PM through 30-day-long-term intragastric administration, and the contents of the jejunum, ileum, and colon were analyzed by 16S rRNA gene sequencing technology for microbial diversity, and relevant experiments were verified according to the analysis results so as to comprehensively evaluate the effects of PM on the intestinal flora...
March 6, 2024: Marine Drugs
https://read.qxmd.com/read/38535317/integrative-multiomics-approach-to-skin-the-sinergy-between-individualised-medicine-and-futuristic-precision-skin-care
#26
REVIEW
Angelica Dessì, Roberta Pintus, Vassilios Fanos, Alice Bosco
The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that of the gastrointestinal tract. Moreover, there is an important communication pathway along the gut-brain-skin axis, especially associated with the modulation of neurotransmitters by the microbiota...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38535233/the-effect-of-green-extraction-technologies-on-the-chemical-composition-of-medicinal-chaga-mushroom-extracts
#27
JOURNAL ARTICLE
Vesna Lazić, Anita Klaus, Maja Kozarski, Ana Doroški, Tomislav Tosti, Siniša Simić, Jovana Vunduk
The mushroom industry should implement green extraction technologies; however, there is not enough information on the differences between these techniques expressed as the chemical composition of the resulting extract. In this study, selected types of green extraction techniques (GETs) were used on Chaga ( Inonotus obliquus ) (Fr.) Pilát from Serbia (IS) and Mongolia (IM) to examine the differences that would enable the composition-based technology choices in the mushroom supplement industry. Subcritical water extraction (SWE), microwave-assisted (MW) extraction, and ultrasonic-assisted extraction (VAE) were used to prepare the extracts...
March 19, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535230/hsp90-mediated-multi-drug-resistance-in-dna-polymerase-defective-strains-of-candida-albicans
#28
JOURNAL ARTICLE
Bhabasha Gyanadeep Utkalaja, Satya Ranjan Sahu, Sushree Subhashree Parida, Narottam Acharya
The incidence of infections caused by Candida species, specifically by drug-resistant isolates, is a major health concern as they can disseminate to and colonize most vital organs, enhancing morbidity and mortality. Several molecular mechanisms have been reported to be involved in drug resistance. These are mostly drug- and isolate-specific. Here, we characterized three different genetically modified strains of C. albicans that were multi-drug-resistant (MDR) and deciphered a uniform mechanism responsible for resistance...
March 19, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535229/the-oxidative-stress-response-highly-depends-on-glucose-and-iron-availability-in-aspergillus-fumigatus
#29
JOURNAL ARTICLE
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H2 O2 treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions...
March 18, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535219/chromosome-level-assembly-and-comparative-genomic-analysis-of-suillus-bovinus-provides-insights-into-the-mechanism-of-mycorrhizal-symbiosis
#30
JOURNAL ARTICLE
Jinhua Zhang, Mengya An, Yanliu Chen, Shengkun Wang, Junfeng Liang
Suillus bovinus is a wild edible ectomycorrhizal fungus with important economic and ecological value, which often forms an ectomycorrhiza with pine trees. We know little about the mechanisms associated with the metabolism and symbiosis of S. bovinus and its effects on the nutritional value. In this study, the whole-genome sequencing of S. bovinus was performed using Illumina, HiFi, and Hi-C technologies, and the sequencing data were subjected to genome assembly, gene prediction, and functional annotation to obtain a high-quality chromosome-level genome of S...
March 13, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535218/importance-of-the-aspergillus-fumigatus-mismatch-repair-protein-msh6-in-antifungal-resistance-development
#31
JOURNAL ARTICLE
Jose Lucio, Irene Gonzalez-Jimenez, Alejandra Roldan, Jorge Amich, Laura Alcazar-Fuoli, Emilia Mellado
One of the systems responsible for the recognition and repair of mistakes occurring during cell replication is the DNA mismatch repair (MMR) system. Two major protein complexes constitute the MMR pathway: MutS and MutL. Here, we investigated the possible relation of four A. fumigatus MMR genes ( msh 2, msh 6, pms 1, and mlh 1) with the development of azole resistance related to the phenomenon of multi-drug resistance. We examined the MMR gene variations in 163 Aspergillus fumigatus genomes. Our analysis showed that genes msh 2, pms 1, and mlh 1 have low genetic variability and do not seem to correlate with drug resistance...
March 12, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535216/-fggmtb-plays-an-important-role-in-growth-reproduction-virulence-and-deoxynivalenol-biosynthesis-of-fusarium-graminearum
#32
JOURNAL ARTICLE
Chenming Zhao, Xiaoyue Yang, Wenqiang Jiang, Guifen Zhang, Dongfang Ma
GDP-mannose transporters (GMTs) have been implicated in the virulence of some important pathogenic fungi, and guanosine diphosphate (GDP) mannose transporters transport GDP-mannose from the cytosol to the Golgi lumen prior to mannosylation, where mannose attaches to the modified protein. GMTs could be potential targets for new antifungal drugs, as disruption of any step in GDP-mannose biosynthesis can affect fungal viability, growth, or virulence. To date, the GDP-mannose transporter has been extensively studied in yeast, but its biological function in fungi, particularly F...
March 11, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535187/comparative-transcriptome-profiles-of-the-response-of-mycelia-of-the-genus-morchella-to-temperature-stress-an-examination-of-potential-resistance-mechanisms
#33
JOURNAL ARTICLE
Yihong Yue, Haibo Hao, Qian Wang, Tingting Xiao, Yuchen Zhang, Hui Chen, Jinjing Zhang
Temperature and moisture belong to the most important environmental factors affecting the growth and development of fungi. However, the effect of temperature on the mycelia of the edible Morchella mushrooms has not been determined. Here, a comprehensive analysis was performed to determine the influence of culture temperature on 13 strains of mycelia of three Morchella species ( Morchella sextelata , Morchella septimelata , and Morchella importuna ) at 5 °C, 10 °C, 15 °C, 20 °C, 25 °C, and 30 °C...
February 27, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535173/the-dynamic-interaction-between-oil-palm-and-phytophthora-palmivora-in-bud-rot-disease-insights-from-transcriptomic-analysis-and-network-modelling
#34
JOURNAL ARTICLE
Mariandrea García-Gaona, David Botero-Rozo, Leonardo Araque, Hernán Mauricio Romero
Bud Rot, caused by Phytophthora palmivora , is considered one of the main diseases affecting African oil palm ( Elaeis guineensis ). In this study, we investigated the in vitro molecular dynamics of the pathogen-host interaction by analyzing gene expression profiles from oil palm genotypes that were either susceptible or resistant to the disease. We observed distinct interactions of P. palmivora with resistant and susceptible oil palms through co-expression network analysis. When interacting with susceptible genotypes, P...
February 20, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535111/rna-binding-proteins-in-cardiomyopathies
#35
REVIEW
De-Li Shi
The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction. Dysfunctions of RNA-binding proteins impair heart development and cause the main types of cardiomyopathies, which represent a heterogenous group of abnormalities that severely affect heart structure and function...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534984/clinical-research-into-central-nervous-system-inflammatory-demyelinating-diseases-related-to-covid-19-vaccines
#36
JOURNAL ARTICLE
Mei-Yun Cheng, Hsuan-Chen Ho, Jung-Lung Hsu, Yi Wang, Linyi Chen, Siew-Na Lim, Ming-Feng Liao, Long-Sun Ro
Various vaccines have been developed in response to the SARS-CoV-2 pandemic, and the safety of vaccines has become an important issue. COVID-19 vaccine-related central nervous system inflammatory demyelinating diseases (CNS IDDs) have been reported recently. We present one case of AstraZeneca vaccine-related myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease and a literature review of another 78 patients published from January 2020 to October 2022. Patients were divided into three vaccine types (viral vector, mRNA, and inactivated vaccines) for further analyses...
March 20, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534932/itgav-promotes-the-progression-of-head-and-neck-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
Lingyi Xu, Jeremy G Barrett, Jiayi Peng, Suk Li, Diana Messadi, Shen Hu
Head and neck squamous cell carcinoma (HNSCC) refers to the malignancy of squamous cells in the head and neck region. Ranked as the seventh most common cancer worldwide, HNSCC has a very low survival rate, highlighting the importance of finding therapeutic targets for the disease. Integrins are cell surface receptors that play a crucial role in mediating cellular interactions with the extracellular matrix (ECM). Within this protein family, Integrin αV (ITGAV) has received attention for its important functional role in cancer progression...
March 1, 2024: Current Oncology
https://read.qxmd.com/read/38534877/effect-of-fibrillin-2-on-differentiation-into-periodontal-ligament-stem-cell-like-cells-derived-from-human-induced-pluripotent-stem-cells
#38
JOURNAL ARTICLE
Sayuri Hamano, Daiki Yamashita, Daigaku Hasegawa, Hideki Sugii, Tomohiro Itoyama, Hidefumi Maeda
Periodontal tissue regeneration is important for preserving teeth. Periodontal ligament stem cells (PDLSCs) are useful in periodontal tissue regeneration, however tooth extraction is required to obtain these cells. Therefore, we focused on induced pluripotent stem (iPS) cells and established a method to obtain PDLSC-like cells from iPS cells. Specifically, we first differentiated iPS cells into neural crest-like cells (iNCs). Next, we obtained PDLSC-like cells (iPDLSCs) by culturing iNCs on extracellular matrix (ECM) derived from human primary periodontal ligament cells (HPDLCs)...
March 27, 2024: Stem Cells and Development
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#39
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
https://read.qxmd.com/read/38534847/application-of-machine-learning-in-the-quantitative-analysis-of-the-surface-characteristics-of-highly-abundant-cytoplasmic-proteins-toward-ai-based-biomimetics
#40
JOURNAL ARTICLE
Jooa Moon, Guanghao Hu, Tomohiro Hayashi
Proteins in the crowded environment of human cells have often been studied regarding nonspecific interactions, misfolding, and aggregation, which may cause cellular malfunction and disease. Specifically, proteins with high abundance are more susceptible to these issues due to the law of mass action. Therefore, the surfaces of highly abundant cytoplasmic (HAC) proteins directly exposed to the environment can exhibit specific physicochemical, structural, and geometrical characteristics that reduce nonspecific interactions and adapt to the environment...
March 6, 2024: Biomimetics
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