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https://www.readbyqxmd.com/read/28088000/efficient-degradation-of-butylparaben-by-gamma-radiolysis
#1
Jhimli Paul Guin, Y K Bhardwaj, Lalit Varshney
Gamma radiolysis and ozonolysis are two competitive advanced oxidation processes for degradation of organic pollutants present in the ground water. In this paper, the gamma radiolytic degradation of an emerging organic pollutant Butylparaben (BP) in aqueous solution has been investigated for the first time at different absorbed doses. The effect of the absorbed dose rate in the degradation and mineralization of BP has been investigated. About 65% mineralization of BP was observed at absorbed dose of 70kGy and dose rate of 0...
December 24, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28087974/application-of-z-sinapinic-matrix-in-peptide-maldi-ms-analysis
#2
María L Salum, Silvana L Giudicessi, Tobías Schmidt De León, Silvia A Camperi, Rosa Erra-Balsells
Since introduction of sinapinic acid (SA) and α-cyano-4-hydroxycinnamic acid as matrices successful application of matrix assisted laser desorption/ionization mass spectrometry started for protein/polypeptides. Both show some limitations in short peptide analysis because matrix clusters are quite abundant. Cinnamics currently used are E-cinnamics. Here Z-SA as matrix for peptides is studied and compared with E-SA and CHCA. Minor number of clusters are always observed in the low m/z region allowing the detection of short peptides...
January 14, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28087621/the-hook-region-of-voltage-gated-ca2-channel-%C3%AE-subunits-senses-and-transmits-pip2-signals-to-the-gate
#3
Cheon-Gyu Park, Yongsoo Park, Byung-Chang Suh
The β subunit of voltage-gated Ca(2+) (CaV) channels plays an important role in regulating gating of the α1 pore-forming subunit and its regulation by phosphatidylinositol 4,5-bisphosphate (PIP2). Subcellular localization of the CaV β subunit is critical for this effect; N-terminal-dependent membrane targeting of the β subunit slows inactivation and decreases PIP2 sensitivity. Here, we provide evidence that the HOOK region of the β subunit plays an important role in the regulation of CaV biophysics. Based on amino acid composition, we broadly divide the HOOK region into three domains: S (polyserine), A (polyacidic), and B (polybasic)...
January 13, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28087526/rapid-enrichment-of-dehalococcoides-like-bacteria-by-partial-hydrophobic-separation
#4
Hanna R Temme, Kipp Sande, Tao Yan, Paige J Novak
: Organohalide respiring bacteria can be difficult to enrich and isolate, which can limit research on these important organisms. The goal of this research was to develop a method to rapidly (minutes to days) enrich these organisms from a mixed community. The method presented is based on the hypothesis that organohalide respiring bacteria would be more hydrophobic than other bacteria as they dehalogenate hydrophobic compounds. The developed method tests this hypothesis by separating a portion of putative organohalide respiring bacteria, those phylogenetically related to Dehalococcoides mccartyi, at the interface between a hydrophobic organic solvent and aqueous media...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28087380/polymeric-mixed-micelles-as-nanomedicines-achievements-and-perspectives
#5
REVIEW
Maximiliano Cagel, Fiorella C Tesan, Ezequiel Bernabeu, Maria J Salgueiro, Marcela B Zubillaga, Marcela A Moretton, Diego A Chiappetta
During the past few decades, polymeric micelles have raised special attention as novel nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous diseases. These nanocarriers exhibit several in vitro and in vivo advantages as well as increased stability and solubility to hydrophobic drugs. An interesting approach for optimizing these properties and overcoming some of their disadvantages is the combination of two or more polymers in order to assemble polymeric mixed micelles. This review article gives an overview on the current state of the art of several mixed micellar formulations as nanocarriers for drugs and imaging probes, evaluating their ongoing status (preclinical or clinical stage), with special emphasis on type of copolymers, physicochemical properties, in vivo progress achieved so far and toxicity profiles...
January 10, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28081456/robust-tough-and-anti-fatigue-cationic-latex-composite-hydrogels-based-on-dual-physically-cross-linked-networks
#6
Song Gu, Lijie Duan, Xiuyan Ren, Guang Hui Gao
Dual physically cross-linked hydrogels, which are triggered by cationic latexes as hydrophobic association and ionic crosslinking centers, were easily fabricated via a one-pot in situ polymerization method. First, the hydrophobic alkyl chains of hydrophobic monomers are adsorbed on the surface of latex microspheres and stabilized in the presence of surfactants, forming hydrophobic association centers as the first physical crosslinking points. Meanwhile, the anionic sulfate radicals dissociated by persulphate are attracted towards the cationic molecular chains of latex microspheres through ionic interactions, forming the secondary physical crosslinking centers, and initiate the copolymerization between acrylamide and hydrophobic vinyl monomers...
January 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28081368/smart-metal-organic-framework-coatings-triggered-anti-biofilm-compound-release
#7
Birgit Claes, Tom Boudewijns, Laurens Muchez, Geert Hooyberghs, Erik V Van der Eycken, Jozef Vanderleyden, Hans P Steenackers, Dirk E De Vos
Metal-organic frameworks (MOFs) have a large potential for delivery of active molecules. Here, a MOF coating is investigated as a smart host matrix for triggered release of anti-biofilm compounds. Besides a coating consisting of the regular Fe-terephthalate MIL-88B(Fe), a new hydrophobic MIL-88B(Fe) coating is synthesized in hydrothermal conditions using palmitic acid as a lattice terminating group. These porous materials are used as a host matrix for the anti-biofilm compound 5-(4-chlorophenyl)-N-(2-isobutyl)-2-aminoimidazole, which has a specific biofilm inhibiting effect at concentrations at which no activity against planktonic cells is detected...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28081197/morphine-withdrawal-modifies-prion-protein-expression-in-rat-hippocampus
#8
Vincenzo Mattei, Stefano Martellucci, Francesca Santilli, Valeria Manganelli, Tina Garofalo, Niccolò Candelise, Alessandra Caruso, Maurizio Sorice, Sergio Scaccianoce, Roberta Misasi
The hippocampus is a vulnerable brain structure susceptible to damage during aging and chronic stress. Repeated exposure to opioids may alter the brain so that it functions normally when the drugs are present, thus, a prolonged withdrawal might lead to homeostatic changes headed for the restoration of the physiological state. Abuse of morphine may lead to Reacting Oxygen Species-induced neurodegeneration and apoptosis. It has been proposed that during morphine withdrawal, stress responses might be responsible, at least in part, for long-term changes of hippocampal plasticity...
2017: PloS One
https://www.readbyqxmd.com/read/28080057/identification-of-binding-modes-for-amino-naphthalene-2-cyanoacrylate-anca-probes-to-amyloid-fibrils-from-molecular-dynamics-simulations
#9
Huan He, Juan Xu, Dan-Yang Cheng, Li Fu, Yu-Shu Ge, Feng-Lei Jiang, Yi Liu
Amino naphthalene 2-Cyanoacrylate (ANCA) probe is a kind of fluorescent amyloid binding probe that can report a different fluorescence emission when bound to different types of amyloid deposits in tissue, while their interactions with amyloid fibrils remain unclear due to the insoluble nature of amyloid fibrils. Here, all atom molecular dynamics simulations were used to investigate the interaction between ANCA probes with three different amyloid fibrils. Two common binding modes of ANCA probes on Aβ40 amyloid fibrils were identified by cluster analysis of multiple simulations...
January 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28080053/lipid-drug-conjugate-for-enhancing-drug-delivery
#10
Danielle Irby, Chengan Du, Feng Li
Lipid-drug conjugates (LDCs) are drug molecules that have been covalently modified with lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes other properties of drugs. The conjugates demonstrate several advantages including improved oral bioavailability, improved targeting to the lymphatic system, enhanced tumor targeting, and reduced toxicity. Based on the chemical nature of drugs and lipids, various conjugation strategies and chemical linkers can be utilized to synthesize LDCs...
January 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28079979/a-general-strategy-to-enhance-the-performance-of-dye-sensitized-solar-cells-by-incorporating-light-harvesting-dye-with-hydrophobic-polydiacetylene-electrolyte-blocking-layer
#11
Shih-Sheng Sun, Mekonnen Abebayehu Desta, Chia-Wei Liao
A unique strategy for effectively suppressing charge recombination and enhancing light harvesting in dye-sensitized solar cells (DSSCs) is demonstrated by designing a new dipolar organic dye functionalized with a diacetylene unit, which is capable of undergoing photoinduced cross-linking reaction to generate a hydrophobic polydiacetylene layer. The polydiacetylene layer serves as not only an electrolyte-blocking layer to effectively block the approaching of the oxidized redox mediator and supress the dark current but also light-harvesting role by efficient energy transfer to the dipolar dyes...
January 12, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28079890/structural-insight-into-an-evolutionarily-ancient-programmed-cell-death-regulator-the-crystal-structure-of-marine-sponge-bhp2-bound-to-lb-bak-2
#12
Sofia Caria, Mark G Hinds, Marc Kvansakul
Sponges of the porifera family harbor some of the evolutionary most ancient orthologs of the B-cell lymphoma-2 (Bcl-2) family, a protein family critical to regulation of apoptosis. The genome of the sponge Geodia cydonium contains the putative pro-survival Bcl-2 homolog BHP2, which protects sponge tissue as well as mammalian Hek-293 and NIH-3T3 cells against diverse apoptotic stimuli. The Lake Baikal demosponge Lubomirskia baicalensis has been shown to encode both putative pro-survival Bcl-2 (LB-Bcl-2) and pro-apoptotic Bcl-2 members (LB-Bak-2), which have been implied in axis formation (branches) in L...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28079358/cellulose-nanofibril-aerogels-synergistic-improvement-of-hydrophobicity-strength-and-thermal-stability-via-cross-linking-with-diisocyanate
#13
Feng Jiang, You-Lo Hsieh
A facile gelation cross-linking approach was devised to fabricate meso- and macroporous cellulose nanofibril (CNF) aerogels with multiple improved properties. CNF hydrogels made using a freezing-thawing method with a 94 kPa modulus were solvent exchanged with acetone and then cross-linked with methylene diphenyl diisocyanate (MDI) to produce aerogels with significantly improved compressive properties that follow a power law increment against aerogel density with impressive 1.69, 2.49, and 1.43 scaling factors for Young's modulus, yield stress, and ultimate stress, respectively...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28079355/self-assembled-architectures-of-alkynylplatinum-ii-amphiphiles-and-their-structural-optimization-a-balance-of-the-interplay-among-pt%C3%A2-%C3%A2-%C3%A2-pt-%C3%AF-%C3%AF-stacking-and-hydrophobic-hydrophobic-interactions
#14
Heidi Li-Ki Fu, Charlotte Po, Sammual Yu-Lut Leung, Vivian Wing-Wah Yam
A series of alkynylplatinum(II) terpyridine complexes with triethylene glycol units was synthesized, and their self-assembly properties were investigated in solution by UV-vis absorption, emission, and (1)H NMR spectroscopy. The aggregation behaviors of several water-soluble complexes were investigated in aqueous media. Some of them were found to give rise to uniform fibers, suggesting the important role that triethylene glycol units has in regulating their self-assembly properties. Further modifications of these structures through the incorporation of alkyl chains and changes in counter-anions have rendered the complexes more amphiphilic in nature, and the effect of their alkyl chain lengths was studied and optimized...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28079287/triarylmethane-dyes-for-artificial-repellent-cotton-fibers
#15
Adelina Vallribera, Ana Maria Montagut, Erik Gálvez, Rosa María Sebastián, Alexandr Shafir
Families of new hydrophobic and/or oleophobic triarylmethane dyes possessing long hydrocarbon or polyfluorinated chains have been prepared. When covalently grafted upon cotton fabric, these dyes give rise to a new type of colored superhydrophobic fibers.
January 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28079209/dynamic-phase-change-and-local-structures-in-il-containing-mixtures-classical-md-simulations-and-experiments
#16
Yang Wu, Xia Wang, Qiaozhen Liu, Xiaoxue Ma, Dawei Fang, Xuefei Jiang, Wei Guan
The dynamic phase change between a homogeneous mixture and a liquid-liquid biphase and separation of phases are explored in three-component mixtures composed of 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim][PF6]), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]), and water through a classical simulation method and experiment. Different experimental and theoretical tools, including density measurement, dynamic light scattering study, radial distribution, mean square displacement, an interstice model, and statistical function, are used to describe the structural modifications of the ions as a function of solution concentration...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28079200/a-molecular-dynamics-study-of-the-interaction-of-water-with-the-external-surface-of-silicalite-1
#17
Konstantin S Smirnov
The interaction of water with the hydroxylated (010) surface of silicalite-1 was studied by classical molecular dynamics simulations. Interatomic interactions in the system were described using a set of effective potentials combining well-tested BKS and SPC models. The extended force field is shown to correctly reproduce the structural, energy, and dynamical characteristics of the silica surface OH groups. The interaction of water with the hydrophilic silanols leads to an ordering of H2O molecules in the vicinity of the surface...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28079195/a-ph-responsive-molecular-capsule-with-an-acridine-shell-catch-and-release-of-large-hydrophobic-compounds
#18
Mai Kishimoto, Kei Kondo, Munetaka Akita, Michito Yoshizawa
Unlike common polyaromatic hydrocarbons, acridine is a characteristic compound bearing both π-stackable large surfaces and a protonable nitrogen atom. Here we report the first synthesis of a supramolecular capsule with multiple acridine panels. In water, the assembly and disassembly of the capsule reversibly occur under neutral and acidic conditions, respectively (≥10 cycles). Notably, the pH-responsive capsule encapsulates a variety of large hydrophobic compounds (up to 1.6 nm in diameter) such as coumarins, metallophthalocyanines and subphthalocyanine in neutral water and subsequently releases them by simple addition of acid...
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28078525/chitosan-ceramide-coating-on-gold-nanorod-to-improve-its-physiological-stability-and-reduce-the-lipid-surface-related-toxicity
#19
Gantumur Battogtokh, Oyuntuya Gotov, Young Tag Ko
Gold nanoparticles are promising materials for many applications that include imaging, drug delivery, and photothermal therapy. However, AuNPs can be unstable and/or toxic. We purposed to improve the stability and reduce toxicity of gold nanorods (AuNR) upon coating with biocompatible polymer, chitosan-ceramide (CS-CE), without replacing the original layer, CTAB. CS-CE-coated AuNR was prepared by simple mixing for 24 h and purified by centrifugation. The coating was confirmed by UV-Vis absorption analysis and surface charge and size measurement...
January 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28078416/poly-ethylene-glycol-functionalization-of-monolithic-poly-divinyl-benzene-for-improved-miniaturized-solid-phase-extraction-of-protein-rich-samples
#20
Esme Candish, Aminreza Khodabandeh, Marianne Gaborieau, Thomas Rodemann, Robert A Shellie, Andrew A Gooley, Emily F Hilder
Non-specific protein adsorption on hydrophobic solid phase extraction (SPE) adsorbents can reduce the efficacy of purification. To improve sample clean-up, poly(divinyl benzene) (PDVB) monoliths grafted with hydrophilic polyethylene glycol methacrylate (PEGMA) were developed. Residual vinyl groups (RVGs) of the PDVB were employed as anchor points for PEGMA grafting. Two PEGMA monomers, M n 360 and 950, were compared for graft solutions containing 5-20% monomer. Protein binding was qualitatively screened using fluorescently labeled human serum albumin (HSA) to determine optimal PEGMA concentration...
January 11, 2017: Analytical and Bioanalytical Chemistry
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