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https://www.readbyqxmd.com/read/29245182/an-efficient-parallel-simulation-of-unsteady-blood-flows-in-patient-specific-pulmonary-artery
#1
Fande Kong, Vitaly Kheyfets, Ender Finol, Xiao-Chuan Cai
Simulation of blood flows in the pulmonary artery provides some insight into certain diseases by examining the relationship between some continuum metrics, e.g. the wall shear stress acting on the vascular endothelium, which responds to flow-induced mechanical forces by releasing vasodilators/constrictors. In [?kheyfets2015patient], V. Kheyfets studies numerically a patient-specific pulmonary circulation to show that decreasing wall shear stress is correlated with increasing pulmonary vascular impedance. In this paper, we develop a scalable parallel algorithm based on domain decomposition methods to investigate an unsteady model with patient specific pulsatile waveforms as the inlet boundary condition...
December 15, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29245144/the-myorobot-a-novel-automated-biomechatronics-system-to-assess-voltage-ca2-biosensors-and-active-passive-biomechanics-in-muscle-and-biomaterials
#2
M Haug, B Reischl, G Prölß, C Pollmann, T Buckert, C Keidel, S Schürmann, M Hock, S Rupitsch, M Heckel, T Pöschel, T Scheibel, C Haynl, L Kiriaev, S I Head, O Friedrich
We engineered an automated biomechatronics system, MyoRobot, for robust objective and versatile assessment of muscle or polymer materials (bio-)mechanics. It covers multiple levels of muscle biosensor assessment, e.g. membrane voltage or contractile apparatus Ca2+ ion responses (force resolution 1µN, 0-10mN for the given sensor; [Ca2+] range ~ 100nM-25µM). It replaces previously tedious manual protocols to obtain exhaustive information on active/passive biomechanical properties across various morphological tissue levels...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29245032/atomic-force-microscopy-capable-of-vibration-isolation-with-low-stiffness-z-axis-actuation
#3
Shingo Ito, Georg Schitter
For high-resolution imaging without bulky external vibration isolation, this paper presents an atomic force microscope (AFM) capable of vibration isolation with its internal Z-axis (vertical) actuators moving the AFM probe. Lorentz actuators (voice coil actuators) are used for the Z-axis actuation, and flexures guiding the motion are designed to have a low stiffness between the mover and the base. The low stiffness enables a large Z-axis actuation of more than 700 µm and mechanically isolates the probe from floor vibrations at high frequencies...
December 5, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29244892/alterations-in-the-masticatory-system-in-patients-with-amyotrophic-lateral-sclerosis
#4
Nina Riera-Punet, Jordi Martinez-Gomis, Andrés Paipa, Monica Povedano, Maria Peraire
AIMS: To determine the effect of amyotrophic lateral sclerosis (ALS) on aspects of masticatory function and to assess the relationship between ALS and the prevalence of traumatic mucosal lesions caused by oral self-injury. METHODS: A total of 153 ALS patients and 23 control subjects participated in this cross-sectional study. Clinical characteristics including site of onset, medication, type of feeding, and use of noninvasive mechanical ventilation were recorded...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244838/muscle-function-in-glenohumeral-joint-stability-during-lifting-task
#5
Yoann Blache, Mickaël Begon, Benjamin Michaud, Landry Desmoulins, Paul Allard, Fabien Dal Maso
Ensuring glenohumeral stability during repetitive lifting tasks is a key factor to reduce the risk of shoulder injuries. Nevertheless, the literature reveals some lack concerning the assessment of the muscles that ensure glenohumeral stability during specific lifting tasks. Therefore, the purpose of this study was to assess the stabilization function of shoulder muscles during a lifting task. Kinematics and muscle electromyograms (n = 9) were recorded from 13 healthy adults during a bi-manual lifting task performed from the hip to the shoulder level...
2017: PloS One
https://www.readbyqxmd.com/read/29244819/climbing-ability-of-teneral-and-sclerotized-adult-bed-bugs-and-assessment-of-adhesive-properties-of-the-exoskeletal-fluid-using-atomic-force-microscopy
#6
Kevin R Hinson, Vladimir Reukov, Eric P Benson, Patricia A Zungoli, William C Bridges, Brittany R Ellis, Jinbo Song
We observed that teneral adults (<1 h post-molt) of Cimex lectularius L. appeared more adept at climbing a smooth surface compared to sclerotized adults. Differences in climbing ability on a smooth surface based on sclerotization status were quantified by measuring the height to which bed bugs climbed when confined within a glass vial. The average maximum height climbed by teneral (T) bed bugs (n = 30, height climbed = 4.69 cm) differed significantly (P< 0.01) from recently sclerotized (RS) bed bugs (n = 30, height climbed = 1...
2017: PloS One
https://www.readbyqxmd.com/read/29244818/postural-control-during-quiet-bipedal-standing-in-rats
#7
Tetsuro Funato, Yota Sato, Soichiro Fujiki, Yamato Sato, Shinya Aoi, Kazuo Tsuchiya, Dai Yanagihara
The control of bipedal posture in humans is subject to non-ideal conditions such as delayed sensation and heartbeat noise. However, the controller achieves a high level of functionality by utilizing body dynamics dexterously. In order to elucidate the neural mechanism responsible for postural control, the present study made use of an experimental setup involving rats because they have more accessible neural structures. The experimental design requires rats to stand bipedally in order to obtain a water reward placed in a water supplier above them...
2017: PloS One
https://www.readbyqxmd.com/read/29244804/conditional-knockout-mice-for-the-distal-appendage-protein-cep164-reveal-its-essential-roles-in-airway-multiciliated-cell-differentiation
#8
Saul S Siller, Himanshu Sharma, Shuai Li, June Yang, Yong Zhang, Michael J Holtzman, Wipawee Winuthayanon, Holly Colognato, Bernadette C Holdener, Feng-Qian Li, Ken-Ichi Takemaru
Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport. Despite their clear importance to human biology and health, the molecular mechanisms underlying multiciliated cell differentiation are poorly understood. Prior studies implicate the distal appendage/transition fiber protein CEP164 as a central regulator of primary ciliogenesis; however, its role in multiciliogenesis remains unknown...
December 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29244782/efficacy-of-blunt-force-trauma-a-novel-mechanical-cervical-dislocation-device-and-a-non-penetrating-captive-bolt-device-for-on-farm-euthanasia-of-pre-weaned-kits-growers-and-adult-commercial-meat-rabbits
#9
Jessica L Walsh, Aaron Percival, Patricia V Turner
The commercial meat rabbit industry is without validated on-farm euthanasia methods, potentially resulting in inadequate euthanasia protocols. We evaluated blunt force trauma (BFT), a mechanical cervical dislocation device (MCD), and a non-penetrating captive bolt device (NPCB) for euthanasia of pre-weaned kits, growers, and adult rabbits. Trials were conducted on three commercial meat rabbit farms using 170 cull rabbits. Insensibility was assessed by evaluating absence of brainstem and spinal reflexes, rhythmic breathing, and vocalizations...
December 15, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29244769/effects-of-uv-ozone-treatment-on-sensing-behaviours-of-egfets-with-al%C3%A2-o%C3%A2-sensing-film
#10
Cuiling Sun, Ruixue Zeng, Junkai Zhang, Zhi-Jun Qiu, Dongping Wu
The effects of UV-ozone (UVO) treatment on the sensing behaviours of extended-gate field-effect transistors (EGFETs) that use Al₂O₃ as the sensing film have been investigated. The Al₂O₃ sensing films are UVO-treated with various duration times and the corresponding EGFET sensing behaviours, such as sensitivity, hysteresis, and long-term stability, are electrically evaluated under various measurement conditions. Physical analysis is also performed to characterize the surface conditions of the UVO-treated sensing films using X-ray photoelectron spectroscopy and atomic force microscopy...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244737/investigation-of-flat-clinching-process-combined-with-material-forming-technology-for-aluminum-alloy
#11
Chao Chen, Shengdun Zhao, Xiaolan Han, Yongfei Wang, Xuzhe Zhao
In recent years, the use of aluminum alloy has tended to increase for building lightweight automobiles to reduce their automotive weight, which is helpful to save energy and protect the environment. In order to join aluminum alloy, a flat-clinching process combined with material forming technology was investigated to join aluminum alloy sheets using an experimental and a numerical method. Al1060 was chosen as the material of the sheet, and DEFORM-2D software was used to build the numerical model. After the numerical model was validated by the experimental results, the influences of punch diameter and holder force on the materials deforming behavior of the clinched joint were analyzed using the numerical model...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244730/isolation-and-characterization-of-ftsz-genes-in-cassava
#12
Meng-Ting Geng, Yi Min, Yuan Yao, Xia Chen, Jie Fan, Shuai Yuan, Lei Wang, Chong Sun, Fan Zhang, Lu Shang, Yun-Lin Wang, Rui-Mei Li, Shao-Ping Fu, Rui-Jun Duan, Jiao Liu, Xin-Wen Hu, Jian-Chun Guo
The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFtsZ1 with a putative signal peptide at N-terminal, has six exons, and is classed to FtsZ1 clade. MeFtsZ2-1 and MeFtsZ2-2 without a putative signal peptide, have seven exons, and are classed to FtsZ2 clade...
December 15, 2017: Genes
https://www.readbyqxmd.com/read/29244694/failure-of-patellar-plating-with-mini-fragment-implants-a-case-report
#13
Daniel T Miles, Matthew L Graves, Clay A Spitler, Patrick F Bergin
CASE: A 40-year-old woman presented to the emergency department with a comminuted fracture of the patella with separation of the bone fragments. The patient underwent an open reduction and osteosynthesis using medial and lateral 2.0-mm nonlocking plates, which subsequently led to pain in the anterior and posterior aspects of the knee. CONCLUSION: In this patient, bicolumnar nonlocking plating was unable to adequately resist the tensile forces of the extensor mechanism...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244659/intra-articular-patellar-dislocation-a-technique-for-closed-reduction-a-case-report-and-review-of-the-literature
#14
Lachlan Wight, Dugal James
CASE: An 87-year-old man fell onto a flexed knee and sustained a closed intra-articular patellar dislocation. A closed reduction was performed under intravenous sedation by flexing the knee to 90°, applying an anterior drawer force to the tibia, and applying pressure to the inferior pole of the patella. The day after reduction, weight-bearing was begun in a hinged brace set at 0° to 90°. Full function was regained by 6 weeks postreduction. CONCLUSION: Intra-articular patellar dislocation may present as an unusual cause of a locked knee...
December 13, 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244535/whether-flexible-flatfoot-needs-the-treatment-an-observation-of-plantar-pressure-effects-on-adults-with-flexible-flatfoot-by-wearing-over-the-counter-insoles-when-walking-on-level-surface-upstairs-and-downstairs
#15
JunNa Zhai, Jue Wang, YuSheng Qiu
BACKGROUND: Orthotic insole is one popular physiotherapy for flatfoot. However, the effects and if flexible flatfoot needs the treatment are not clear and how the plantar pressure change while walking upstairs and downstairs had not been studied. This study observed the plantar pressure of different walking condition to find out the answers. METHODS: Fifteen adults with flexible flatfoot and fifteen adults with normal foot were examined while walking on a level surface, walking up and down 10 cm and 20 cm stairs before treatment...
December 15, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29244534/assessing-infant-carriage-systems-ground-reaction-force-implications-for-gait-of-the-caregiver
#16
Mathew B Brown, Caroline J Digby-Bowl, Samuel D Todd
Objective To assess the acute alterations of anterior infant carriage systems on the ground reaction force experienced during over-ground walking. Background Previous research has identified the alterations in posture and gait associated with an increased anterior load (external or internal); however, the forces applied to the system due to the altered posture during over-ground walking have not been established. Method Thirteen mixed gender participants completed 45 over-ground walking trials at a self-selected pace under three loaded conditions (unloaded, semi-structured carrier 9...
December 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29244523/hip-distraction-without-a-perineal-post-a-prospective-study-of-1000-hip-arthroscopy-cases
#17
Omer Mei-Dan, Matthew J Kraeutler, Tigran Garabekyan, Jesse A Goodrich, David A Young
BACKGROUND: Hip arthroscopy has traditionally been performed with a perineal post, resulting in various groin-related complications, including pudendal nerve neurapraxias, vaginal tears, and scrotal necrosis. PURPOSE: To assess the safety of a technique for hip distraction without the use of a perineal post. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We prospectively analyzed a consecutive cohort of 1000 hips presenting to a dedicated hip preservation clinic; all patients had hip pain and were subsequently treated with hip arthroscopy...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29244513/scission-free-energies-for-wormlike-surfactant-micelles-development-of-a-simulation-protocol-application-and-validation-for-personal-care-formulations
#18
Huan Wang, Xueming Tang, David Michael Eike, Ronald G Larson, Peter H Koenig
We present a scheme to calculate wormlike micelle scission free energies from a potential of mean force (PMF) derived from a Weighted Histogram Analysis Method (WHAM) applied to coarse grained dissipative particle dynamics (DPD) simulations. In contrast to previous related work, we use a specially chosen external potential based on a reaction coordinate that reversibly drives surfactants out of the nascent scission location. For the application to a model body wash formulation, we predict how addition of NaCl and small molecules such as perfume raw materials (PRMs) affect scission energies...
December 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29244508/diffusion-of-supercritical-fluids-through-single-layer-nanoporous-solids-theory-and-molecular-simulations
#19
Fouad Oulebsir, Romain Vermorel, Guillaume Galliero
With the advent of graphene material, membranes based on single-layer nanoporous solids appear as promising devices for fluid separation, be it liquid or gaseous mixtures. The design of such architectured porous materials would greatly benefit from accurate models that can predict their transport and separation properties. More specifically, there is no universal understanding of how parameters such as temperature, fluid loading conditions or the ratio of the pore size to the fluid molecular diameter influence the permeation process...
December 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29244486/going-vertical-to-improve-the-accuracy-of-atomic-force-microscopy-based-single-molecule-force-spectroscopy
#20
Robert Walder, William J Van Patten, Ayush Adhikari, Thomas T Perkins
Single-molecule force spectroscopy (SMFS) is a powerful technique to characterize the energy landscape of individual proteins, the mechanical properties of nucleic acids, and the strength of receptor-ligand interactions. Atomic-force-microscopy (AFM)-based SMFS benefits from ongoing progress in improving the precision and stability of cantilevers and the AFM itself. Underappreciated is that the accuracy of such AFM studies remains hindered by inadvertently stretching molecules at an angle while measuring only the vertical component of the force and extension, degrading both measurements...
December 15, 2017: ACS Nano
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