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https://www.readbyqxmd.com/read/29679933/slip-avoidance-strategies-in-children-with-bilateral-spastic-cerebral-palsy-and-crouch-gait
#1
Ana Francisca Rozin Kleiner, Ilaria Pacifici, Claudia Condoluci, Chiarella Sforza, Manuela Galli
BACKGROUND: A slip occurs when the required friction (RCOF) to prevent slipping at the foot/floor interfaces exceeds the available friction. The RCOF is dependent upon the biomechanics features of individuals and their gait. On the other hand, the available friction depends on environmental features. Once individuals with crouch gait have their biomechanics of gait completely altered, how do they interact with a supporting surface? The aim was to quantify the RCOF in children with bilateral spastic cerebral palsy (BSCP) and crouch gait...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29679921/electromyographic-and-biomechanical-analysis-of-step-negotiation-in-charcot-marie-tooth-subjects-whose-level-walk-is-not-impaired
#2
Tiziana Lencioni, Giuseppe Piscosquito, Marco Rabuffetti, Enrica Di Sipio, Manuela Diverio, Isabella Moroni, Luca Padua, Emanuela Pagliano, Angelo Schenone, Davide Pareyson, Maurizio Ferrarin
BACKGROUND: Charcot-Marie-Tooth (CMT) is a slowly progressive disease characterized by muscular weakness and wasting with a length-dependent pattern. Mildly affected CMT subjects showed slight alteration of walking compared to healthy subjects (HS). RESEARCH QUESTION: To investigate the biomechanics of step negotiation, a task that requires greater muscle strength and balance control compared to level walking, in CMT subjects without primary locomotor deficits (foot drop and push off deficit) during walking...
April 13, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29679756/myh9-structure-functions-and-role-of-non-muscle-myosin-iia-in-human-disease
#3
REVIEW
Alessandro Pecci, Xuefei Ma, Anna Savoia, Robert S Adelstein
The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed cytoplasmic myosin that participates in a variety of processes requiring the generation of intracellular chemomechanical force and translocation of the actin cytoskeleton. Non-muscle myosin IIA functions are regulated by phosphorylation of its 20 kDa light chain, of the heavy chain, and by interactions with other proteins. Variants of MYH9 cause an autosomal-dominant disorder, termed MYH9-related disease, and may be involved in other conditions, such as chronic kidney disease, non-syndromic deafness, and cancer...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679689/bovine-serum-albumin-binding-study-to-erlotinib-using-surface-plasmon-resonance-and-molecular-docking-methods
#4
Parvin Taghipour, Mostafa Zakariazadeh, Maryam Sharifi, Jafar Ezzati Nazhad Dolatabadi, Abolfazl Barzegar
Bovine serum albumin (BSA) is the most abundant protein in the blood circulation and it is commonly used for drug delivery in blood. Therefore, we aim to study BSA interaction with erlotinib as an anticancer drug using surface plasmon resonance (SPR) and molecular modeling methods under physiological conditions (pH = 7.4). BSA immobilized on carboxymethyl dextran hydrogel Au chip (CMD) after activation with N-hydroxysuccinimide and N-ethyl-N-(3-diethylaminopropyl) carbodiimide and then the erlotinib binding to BSA at different concentrations was evaluated...
April 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29679659/measurement-of-emotional-contagion-using-synchronization-of-heart-rhythm-pattern-between-two-persons-application-to-sales-managers-and-sales-force-synchronization
#5
Sangin Park, Soo Ji Choi, Sungchul Mun, Mincheol Whang
The purpose of this study was to measure emotional contagion, determine its direction, and compare the intensity between positive and negative contagion using the synchronization of heart rhythm pattern (HRP). A total of 64 undergraduate students (32 women and 32 men) participated in the experiment, and were randomly categorized as either leaders or followers. Followers were required to imitate the facial expression (happy and sad) of the leader (emotional contagion) or of a facial image (emotional non-contagion)...
April 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29679480/association-between-online-information-seeking-and-adherence-to-guidelines-for-breast-and-prostate-cancer-screening
#6
Hankyul Kim, Christopher Filson, Peter Joski, Silke von Esenwein, Joseph Lipscomb
INTRODUCTION: From 2012 through 2014, the US Preventive Services Task Force (USPSTF) recommended biennial mammography for women aged 50 to 75 and recommended against the prostate specific antigen (PSA) test for men of any age, emphasizing informed decision making for patients. Because of time constraints and other patient health priorities, health care providers often do not discuss benefits and risks associated with cancer screening. We analyzed the association between seeking information online about breast and prostate cancer and undergoing mammography and PSA screening...
April 19, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29679411/the-use-of-a-logistic-regression-model-to-develop-a-risk-assessment-of-intraoperatively-acquired-pressure-ulcer
#7
Ling Gao, Lina Yang, Xiaoqin Li, Jin Chen, Juan Du, Xiaoxia Bai, Xianjun Yang
AIMS AND OBJECTIVES: To screen the factors of intraoperatively acquired pressure ulcer (IAPU) and establish a new risk assessment model of IAPU. DESIGN: This is a prospective study. METHODS: A total of 1963 patients who received neurosurgery, orthopaedics, pediatric surgery and cardiac surgery therapy in Sichuan Academy of Medical Science and Provincial People's Hospital in China from October 2015 to October 2016 were enrolled in the study and their clinical parameters were collected...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679360/mental-health-of-the-male-adolescent-and-young-man-the-copenhagen-statement
#8
REVIEW
Timothy R Rice, Lesha D Shah, Pilar Trelles, Shih-Ku Lin, Dinne Skjærlund Christensen, Andreas Walther, Leo Sher
BACKGROUND: Male adolescents and young men benefit when their mental health care is specialized to match their unique gendered and developmental needs. Sensitivity to the social circumstances of this population is important; additionally, the emerging ability to tailor care through knowledge gleaned from the intersection of psychiatry, neurology, and endocrinology informs care. DATA SOURCES: This article summarized the views of six experts in the area of the adolescent and young adult male mental health...
April 20, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29679265/focus-groups-and-in-depth-interviews-to-guide-the-development-of-lung-cancer-screening-informational-materials
#9
Anushree Sharma, Richard O'Connor, Paula Celestino, Samantha Killion, Laurie Griswold-Krupski, Maansi Bansal-Travers
Lung cancer is one of the most lethal cancers in the USA. In 2013, new guidelines issued by the United States Preventive Services Task Force recommended lung cancer screening using low-dose computed tomography among a selected group of high-risk individuals. Specifically, lung cancer screening is recommended for heavy smokers between the ages of 55 to 79, with at least 30 pack-year smoking exposure. Former smokers who meet these guidelines and stopped smoking ≤ 15 years ago are also eligible. There is a need to promote lung cancer screening to increase early diagnosis rates and treatment options, thereby decreasing disease-specific mortality...
April 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#10
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29679255/needle-tissue-interactive-mechanism-and-steering-control-in-image-guided-robot-assisted-minimally-invasive-surgery-a-review
#11
Pan Li, Zhiyong Yang, Shan Jiang
Image-guided robot-assisted minimally invasive surgery is an important medicine procedure used for biopsy or local target therapy. In order to reach the target region not accessible using traditional techniques, long and thin flexible needles are inserted into the soft tissue which has large deformation and nonlinear characteristics. However, the detection results and therapeutic effect are directly influenced by the targeting accuracy of needle steering. For this reason, the needle-tissue interactive mechanism, path planning, and steering control are investigated in this review by searching literatures in the last 10 years, which results in a comprehensive overview of the existing techniques with the main accomplishments, limitations, and recommendations...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29679247/neuromuscular-and-electromechanical-properties-of-ultra-power-athletes-the-traceurs
#12
Sidney Grosprêtre, Philippe Gimenez, Alain Martin
PURPOSE: Practising a power-type activity over years can shape the neuromuscular profile of athletes. This study aimed at comparing the neuromuscular profile of a non-trained group (NT, n = 10) to power athletes practising Parkour (= traceurs, group PK, n = 11), an activity consisting of jumping obstacles mostly in an urban landscape. METHODS: Maximal isometric plantar flexion force (MVC) and rate of torque development (RTD) were evaluated, and neuromuscular function of triceps surae muscles was assessed and compared between groups through the analysis of evoked potentials from posterior tibial nerve stimulation...
April 20, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29679061/the-role-of-macrophage-migration-inhibitory-factor-in-the-function-of-intestinal-barrier
#13
Milica Vujicic, Tamara Saksida, Sanja Despotovic, Svetlana Sokovic Bajic, Ivana Lalić, Ivan Koprivica, Dragica Gajic, Natasa Golic, Maja Tolinacki, Ivana Stojanovic
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679050/misp-regulates-the-iqgap1-cdc42-complex-to-collectively-orchestrate-spindle-orientation-and-mitotic-progression
#14
Barbara Vodicska, Berati Cerikan, Elmar Schiebel, Ingrid Hoffmann
Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases. In most animal cell types, the dynein motor complex is anchored at the cell cortex and exerts pulling forces on astral microtubules to position the spindle. The actin-binding protein MISP controls spindle orientation and mitotic progression in human cells. However, the exact underlying mechanism remains to be elucidated. Here we report that MISP interacts with the multidomain scaffolding protein IQGAP1...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679005/late-miocene-climate-cooling-and-intensification-of-southeast-asian-winter-monsoon
#15
Ann E Holbourn, Wolfgang Kuhnt, Steven C Clemens, Karlos G D Kochhann, Janika Jöhnck, Julia Lübbers, Nils Andersen
The late Miocene offers the opportunity to assess the sensitivity of the Earth's climate to orbital forcing and to changing boundary conditions, such as ice volume and greenhouse gas concentrations, on a warmer-than-modern Earth. Here we investigate the relationships between low- and high-latitude climate variability in an extended succession from the subtropical northwestern Pacific Ocean. Our high-resolution benthic isotope record in combination with paired mixed layer isotope and Mg/Ca-derived temperature data reveal that a long-term cooling trend was synchronous with intensification of the Asian winter monsoon and strengthening of the biological pump from ~7 Ma until ~5...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678956/local-actin-polymerization-during-endocytic-carrier-formation
#16
REVIEW
Claudia Hinze, Emmanuel Boucrot
Extracellular macromolecules, pathogens and cell surface proteins rely on endocytosis to enter cells. Key steps of endocytic carrier formation are cargo molecule selection, plasma membrane folding and detachment from the cell surface. While dedicated proteins mediate each step, the actin cytoskeleton contributes to all. However, its role can be indirect to the actual molecular events driving endocytosis. Here, we review our understanding of the molecular steps mediating local actin polymerization during the formation of endocytic carriers...
April 20, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29678948/an-rnai-screen-identifies-new-genes-required-for-normal-morphogenesis-of-larval-chordotonal-organs
#17
Abeer Hassan, Yael Timerman, Rana Hamdan, Nitzan Sela, Adel Avetisyan, Naomi Halachmi, Adi Salzberg
The proprioceptive chordotonal organs (ChO) of a fly larva respond to mechanical stimuli generated by muscle contractions and consequent deformations of the cuticle. The ability of the ChO to sense the relative displacement of its epidermal attachment sites likely depends on the correct mechanical properties of the accessory (cap and ligament) and attachment cells that connect the sensory unit (neuron and scolopale cell) to the cuticle. The genetic programs dictating the development of ChO cells with unique morphologies and mechanical properties are largely unknown...
April 20, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29678900/prevention-of-exacerbations-in-patients-with-stable-non-cystic-fibrosis-bronchiectasis-a-systematic-review-and-meta-analysis-of-pharmacological-and-non-pharmacological-therapies
#18
Abd Moain Abu Dabrh, Adam T Hill, Claudia C Dobler, Noor Asi, Wigdan H Farah, Qusay Haydour, Zhen Wang, Khalid Benkhadra, Larry J Prokop, Mohammad Hassan Murad
BACKGROUND: Several pharmacological and non-pharmacological therapies are used to treat stable bronchiectasis of non-cystic fibrosis (CF) aetiology. OBJECTIVE: We conducted a systematic review and meta-analysis to assess the evidence of the effectiveness of pharmacological and non-pharmacological treatment options in patients with stable non-CF bronchiectasis with a focus on reducing exacerbations. STUDY SELECTION: Multiple databases were searched through September 2017...
April 20, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29678756/new-crosslinked-hyaluronan-gel-for-the-prevention-of-intrauterine-adhesions-after-dilation-and-curettage-in-patients-with-delayed-miscarriage-a-prospective-multicenter-randomized-controlled-trial
#19
Xueying Li, Ling Wu, Yanfei Zhou, Xing Fan, Jufang Huang, Juhua Wu, Renxiu Yu, Jianying Lou, Mengjie Yang, Zhihong Yao, Min Xue
STUDY OBJECTIVES: To evaluate the efficacy of a new crosslinked hyaluronan (NCH) gel in reducing formation of intrauterine adhesions (IUAs) after dilation and curettage (D&C). DESIGN: Randomized controlled trial (Canadian Task Force classification I). SETTINGS: Six hospitals for maternal and child healthcare in China. PATIENTS: 300 patients were randomized to undergo D&C for delayed miscarriage without previous history of D&Cs and 26 (9%) were lost to follow-up and excluded from the analysis...
April 17, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29678755/colorectal-anastomotic-stenosis-lesson-learned-after-1643-colorectal-resections-for-deep-infiltrating-endometriosis
#20
Elisa Bertocchi, Giuliano Barugola, Marco Benini, Paolo Bocus, Roberto Rossini, Marcello Ceccaroni, Giacomo Ruffo
STUDY OBJECTIVE: To evaluate incidence, risk factors, and treatment of colorectal anastomotic stenosis in patients who underwent rectosigmoid resection for deep infiltrating endometriosis (DIE). DESIGN: A retrospective analysis of prospective database (Canadian Task Force classification III). SETTING: Public Medical Center PATIENTS: All women who underwent laparoscopic rectosigmoid resections for DIE between January 2002 and December 2016...
April 17, 2018: Journal of Minimally Invasive Gynecology
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