keyword
https://read.qxmd.com/read/38537179/dispersion-control-over-molecule-cohesion-exploiting-and-dissecting-the-tipping-power-of-aromatic-rings
#1
JOURNAL ARTICLE
Ricardo A Mata, Tlektes Zhanabekova, Daniel A Obenchain, Martin A Suhm
ConspectusWe have learned over the past years how London dispersion forces can be effectively used to influence or even qualitatively tip the structure of aggregates and the conformation of single molecules. This happens despite the fact that single dispersion contacts are much weaker than competing polar forces. It is a classical case of strength by numbers, with the importance of London dispersion forces scaling with the system size. Knowledge about the tipping points, however difficult to attain, is necessary for a rational design of intermolecular forces...
March 27, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38537159/pack-year-smoking-history-an-inadequate-and-biased-measure-to-determine-lung-cancer-screening-eligibility
#2
JOURNAL ARTICLE
Alexandra L Potter, Nuo N Xu, Priyanka Senthil, Deepti Srinivasan, Hang Lee, G Scott Gazelle, Lydia Chelala, Wei Zheng, Florian J Fintelmann, Lecia V Sequist, Jessica Donington, Julie R Palmer, Chi-Fu Jeffrey Yang
PURPOSE: Pack-year smoking history is an imperfect and biased measure of cumulative tobacco exposure. The use of pack-year smoking history to determine lung cancer screening eligibility in the current US Preventive Services Task Force (USPSTF) guideline may unintentionally exclude many high-risk individuals, especially those from racial and ethnic minority groups. It is unclear whether using a smoking duration cutoff instead of a smoking pack-year cutoff would improve the selection of individuals for screening...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537158/impact-of-broadening-trial-eligibility-criteria-on-the-inclusion-of-patients-with-brain-metastases-in-cancer-clinical-trials-time-series-analyses-for-2012-2022
#3
JOURNAL ARTICLE
Hong Xiao, Riha Vaidya, Dawn L Hershman, Joseph M Unger
PURPOSE: In October 2017, an ASCO, Friends of Cancer Research (FoCR), and US Food and Drug Administration (ASCO/FoCR/FDA) task force recommended that common eligibility criteria be modified to make trials more inclusive. We examined whether patterns of exclusions regarding patients with brain metastases changed over time in relation to these recommendations. METHODS: Trial eligibility criteria were abstracted from ClinicalTrials.gov for phase I-III US-based interventional clinical trials for patients with advanced breast, colorectal, lung, or melanoma cancers from January 2012 to December 2022...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537080/contributions-of-cerebral-white-matter-hyperintensities-age-and-pedal-perception-to-postural-sway-in-people-living-with-hiv
#4
JOURNAL ARTICLE
Edith V Sullivan, Natalie M Zahr, Qingyu Zhao, Kilian M Pohl, Stephanie A Sassoon, Adolf Pfefferbaum
OBJECTIVE: With aging, people living with HIV (PLWH) have diminishing postural stability that increases liability for falls. Factors and neuromechanisms contributing to instability are incompletely known. Brain white matter abnormalities seen as hyperintense (WMH) signals have been considered to underlie instability in normal aging and PLWH. We questioned whether sway-WMH relations endured after accounting for potentially relevant demographic, physiological, and HIV-related variables...
March 27, 2024: AIDS
https://read.qxmd.com/read/38537052/the-sociocultural-context-of-adolescent-pain-portrayals-of-pain-in-popular-adolescent-media
#5
JOURNAL ARTICLE
Allison Cormier, Kendra Mueri, Maria Pavlova, Anna Hood, Queenie Li, Idia Thurston, Abbie Jordan, Melanie Noel
Research has consistently suggested that media consumption plays a vital role in children's socialization, including the socialization of painful experiences. Past research examining young children's popular media revealed worrisome trends in media depictions of pain; it consisted of narrow depictions of pain, gender stereotypes, and an overwhelming lack of empathy from observers, which could contribute to pain-related stigma. Research has not yet examined how pain is portrayed in adolescent media, despite adolescence being the developmental period when chronic pain often emerges...
March 27, 2024: Pain
https://read.qxmd.com/read/38537024/evaluation-the-stress-distribution-in-root-canals-by-3d-finite-element-analysis-after-the-materials-used-in-reattaching-the-vertically-root-fractured-fragments
#6
JOURNAL ARTICLE
Senem Yiğit Özer, Salih Danişman, Törem Özer
The aim was to evaluate the effect of stress distribution on vertical, horizontal, and oblique forces on the tooth model after reattaching the fragments of the maxillary incisor with vertical root fracture (VRF) using different materials, by 3D finite element analysis (FEA). Tooth with a root canal, spongious, and cortical bone models were designed. VRF was modeled on a tooth with 4 different re-attachment models: Group 1: dual-cure cement (DC)+fiber reinforced composite (FRC), Group 2: DC+polyethylene fiber, Group 3: DC+glass fiber, and Group 4:DC...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537021/impact-of-access-cavity-design-on-fracture-resistance-of-endodontically-treated-maxillary-first-premolar-in-vitro
#7
JOURNAL ARTICLE
Anju Daniel, Abdul Rahman Saleh, Anas Al-Jadaa, Waad Kheder
This study was designed to investigate the impact of access cavity designs on fracture resistance of endodontically treated maxillary first premolars. The study sample consisted of 72 intact maxillary first premolars, randomly divided into six groups (n = 12). A standardized proximal cavity preparation was prepared for all samples using standard bur. Groups I: control group with only standard proximal cavity and no endodontic access, group II: Truss access cavity, group III: Separated access to buccal and palatal canals without removal of dentine in between, group IV: Access to buccal and palatal canals with removal of dentine in between, group V: Traditional access cavity, group VI: Mesio-occlusal-distal cavity (MOD)...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536962/acute-effects-of-vibrating-insoles-on-dynamic-balance-and-gait-quality-in-individuals-with-diabetic-peripheral-neuropathy-a-randomized-crossover-study
#8
JOURNAL ARTICLE
Giorgio Orlando, Steven Brown, Edward Jude, Frank L Bowling, Andrew J M Boulton, Neil D Reeves
OBJECTIVE: This study investigated the effects of vibrating insoles on dynamic balance and gait quality during level and stair walking and explored the influence of vibration type and frequency in individuals with diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS: Twenty-two men with DPN were assessed for gait quality and postural and dynamic balance during walking and stair negotiation using a motion capture system and force plates across seven vibratory insole conditions (Vcs) versus a control (Ctrl) condition (insole without vibration)...
March 27, 2024: Diabetes Care
https://read.qxmd.com/read/38536913/cardiac-tissue-model-of-immune-induced-dysfunction-reveals-the-role-of-free-mitochondrial-dna-and-the-therapeutic-effects-of-exosomes
#9
JOURNAL ARTICLE
Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T Wagner, Erika L Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C Andreazza, Claudia C Dos Santos, Milica Radisic
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute myocarditis. We observed hallmarks of coronavirus disease (COVID-19)-induced myocardial inflammation, as the presence of immune cells augmented the secretion of proinflammatory cytokines, triggered progressive impairment of contractile function, and altered intracellular calcium transients...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536908/tisb-protein-is-the-single-molecular-determinant-underlying-multiple-downstream-effects-of-ofloxacin-in-escherichia-coli
#10
JOURNAL ARTICLE
Julien Cayron, Thierry Oms, Tatjana Schlechtweg, Safia Zedek, Laurence Van Melderen
Bactericidal antibiotics can cause metabolic perturbations that contribute to antibiotic-induced lethality. The molecular mechanism underlying these downstream effects remains unknown. Here, we show that ofloxacin, a fluoroquinolone that poisons DNA gyrase, induces a cascade of metabolic changes that are dependent on an active SOS response. We identified the SOS-regulated TisB protein as the unique molecular determinant responsible for cytoplasmic condensation, proton motive force dissipation, loss of pH homeostasis, and H2 O2 accumulation in Escherichia coli cells treated with high doses of ofloxacin...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536874/gray-whale-eschrichtius-robustus-post-mortem-findings-from-december-2018-through-2021-during-the-unusual-mortality-event-in-the-eastern-north-pacific
#11
JOURNAL ARTICLE
Stephen Raverty, Pádraig Duignan, Denise Greig, Jessica L Huggins, Kathy Burek Huntington, Michael Garner, John Calambokidis, Paul Cottrell, Kerri Danil, Dalin D'Alessandro, Deborah Duffield, Moe Flannery, Frances Md Gulland, Barbie Halaska, Dyanna M Lambourn, Taylor Lehnhart, Jorge Urbán R, Teri Rowles, James Rice, Kate Savage, Kristin Wilkinson, Justin Greenman, Justin Viezbicke, Brendan Cottrell, P Dawn Goley, Maggie Martinez, Deborah Fauquier
Beginning in December 2018, increased numbers of gray whale (Eschrichtius robustus) strandings were reported along the west coast of Mexico, the United States, and Canada, prompting declaration of a gray whale Unusual Mortality Event (UME) by the United States National Marine Fisheries Service. Although strandings declined in 2020 and 2021 from a peak in 2019, the UME is still ongoing as of fall 2023. Between 17 December 2018 and 31 December 2021, 503 animals stranded along the west coast of North America, with 226 strandings in Mexico, 71 in California, 12 in Oregon, 56 in Washington, 21 in British Columbia, and 117 in Alaska...
2024: PloS One
https://read.qxmd.com/read/38536849/a-study-on-smart-home-use-intention-of-elderly-consumers-based-on-technology-acceptance-models
#12
JOURNAL ARTICLE
Chengmin Zhou, Yawen Qian, Jake Kaner
PURPOSE: Smart home devices have great potential to improve the quality of life and independence of older people, positively impacting their health, safety, and comfort. However, Chinese research in this field is still in its early stages. Therefore, more comprehensive and in-depth studies are needed to comprehend the various aspects influencing the acceptance and use of smart homes by older users. PATIENTS AND METHODS: This study adopted the Technology Acceptance Model (TAM) and included perceived usefulness, perceived ease of use, usage intention, intergenerational technology support, perceived value, and perceived risk as extension variables to delve deeper into the behavioral intentions of older users in smart home services...
2024: PloS One
https://read.qxmd.com/read/38536654/surgical-technique-proximal-extension-of-instrumentation-using-sublaminar-bands-for-salvage-of-postoperative-proximal-junctional-failure-in-pediatric-patients
#13
JOURNAL ARTICLE
Mason A Fawcett, Richard M Schwend
PURPOSE: Proximal junctional failure is a complication that can occur following posterior spine surgery with instrumentation. The ability to surgically revise this complication is important for the spine surgeon, yet there is little literature on the topic, especially for pediatric patients. METHODS: The technique we describe involves proximal extension of the existing instrumentation using paired levels of sublaminar bands that allows for a smooth transition of forces at the junction of instrumented and non-instrumented regions of the spine...
March 27, 2024: Spine Deformity
https://read.qxmd.com/read/38536644/hereditary-ttp-upshaw-schulman-syndrome-the-ductus-arteriosus-controls-newborn-survival
#14
REVIEW
Yoshihiro Fujimura
Hereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment. In utero, fetal blood flowing from the pulmonary artery through the ductus arteriosus (DA) to the aorta is under low-shear-force...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38536563/machine-learning-in-risk-prediction-of-continuous-renal-replacement-therapy-after-coronary-artery-bypass-grafting-surgery-in-patients
#15
JOURNAL ARTICLE
Qian Zhang, Peng Zheng, Zhou Hong, Luo Li, Nannan Liu, Zhiping Bian, Xiangjian Chen, Hengfang Wu, Sheng Zhao
OBJECTIVES: This study aimed to develop machine learning models for risk prediction of continuous renal replacement therapy (CRRT) following coronary artery bypass grafting (CABG) surgery in intensive care unit (ICU) patients. METHODS: We extracted CABG patients from the electronic medical record system of the hospital. The endpoint of this study was the requirement for CRRT after CABG surgery. The Boruta method was used for feature selection. Seven machine learning algorithms were developed to train models and validated using 10 fold cross-validation (CV)...
March 27, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38536536/what-keeps-the-style-under-tension-experimental-tests-to-understand-the-biomechanics-of-the-explosive-style-movement-in-marantaceae
#16
JOURNAL ARTICLE
Marcus Jerominek, Regine Claßen-Bockhoff
Pollination in Marantaceae is mediated by an explosive style movement. Before release, style tension is held by the hooded staminode. When a pollinator touches the trigger appendage of the hooded staminode the latter deforms and the style rapidly curls upwards. This movement has been interpreted as a turgor movement by some authors, but recent studies clearly indicate that setup, hold and release of tension are purely mechanical processes. However, in view of the high diversity of hooded staminodes, the question arises what keeps the tension in species with very thin staminodes...
March 27, 2024: Journal of Plant Research
https://read.qxmd.com/read/38536453/braiding-twisting-and-weaving-microscale-fibers-with-capillary-forces
#17
JOURNAL ARTICLE
Ahmed Sherif, Maya Winters Faaborg, Cheng Zeng, Michael P Brenner, Vinothan N Manoharan
Soft materials made from braided or woven microscale fibers can display unique properties that can be exploited in electromagnetic, mechanical, and biomedical applications. These properties depend on the topology of the braids or weaves-that is, the order in which fibers cross one another. Current industrial braiding and weaving machines cannot easily braid or weave micrometer-scale fibers into controllable topologies; they typically apply forces that are large enough to break the fibers, and each machine can typically make only one topology...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536205/single-molecule-exchange-inside-a-nanocage-provides-insights-into-the-origin-of-%C3%AF-%C3%AF-interactions
#18
JOURNAL ARTICLE
Wenying Hao, Bingyuan Guo, Jianchuan Liu, Qianyuan Ren, Shumu Li, Qian Li, Ke Zhou, Lei Liu, Hai-Chen Wu
The attractive interactions between aromatic rings, also known as π-π interactions, have been widely used for decades. However, the origin of π-π interactions remains controversial due to the difficulties in experimentally measuring the weak interactions between π-systems. Here, we construct an elaborate system to accurately compare the strength of the π-π interactions between phenylalanine derivatives via molecular exchange processes inside a protein nanopore. Based on quantitative comparison of binding strength, we find that in most cases, the π-π interaction is primarily driven by dispersive attraction, with the electrostatic interaction playing a secondary role and tending to be repulsive...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38536202/venous-disorders-as-an-occupational-disease-a-systematic-review-on-epidemiology-pathophysiology-and-modification-strategies
#19
REVIEW
Tobias Hirsch, Uwe Wahl, Eberhard Rabe
<b/> Background: Forced postures are common in the workplace. Work in the primary economic sector is characterised by a high degree of physical activity and movement; however, activities in the secondary and tertiary sectors commonly require workers to stand or sit. An expansion of the tertiary sector in recent decades has meant that people in industrialised and emerging economies primarily sit or stand at work. The aim of the systematic review was to identify occupational factors relating to the presence of chronic venous disease (CVD), to place these in the context of developments in the workplace, and to determine whether measures are in place to prevent CVD...
March 27, 2024: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/38536172/adolescent-cardiorespiratory-fitness-and-future-work-ability
#20
JOURNAL ARTICLE
Perttu T T Laakso, Francisco B Ortega, Pertti Huotari, Asko J Tolvanen, Urho M Kujala, Timo T Jaakkola
IMPORTANCE: Although research indicates that low fitness in youth is associated with a higher risk of chronic disability in men, the association of fitness in adolescence with work ability in working men and women remains unknown. OBJECTIVE: To examine the associations of adolescent health-related physical fitness with future work ability. DESIGN, SETTING, AND PARTICIPANTS: This 45-year observational cohort study, conducted in Finland, examined the direct and indirect longitudinal associations of objectively measured health-related fitness in adolescence (in 1976) with self-reported work ability and sickness absence in early middle age (in 2001) and the Work Ability Index in late middle age (in 2021)...
March 4, 2024: JAMA Network Open
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