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https://www.readbyqxmd.com/read/27925645/taking-time-to-feel-our-body-steady-increases-in-heartbeat-perception-accuracy-and-decreases-in-alexithymia-over-9-months-of-contemplative-mental-training
#1
Boris Bornemann, Tania Singer
The ability to accurately perceive signals from the body has been shown to be important for physical and psychological health as well as understanding one's emotions. Despite the importance of this skill, often indexed by heartbeat perception accuracy (HBPa), little is known about its malleability. Here, we investigated whether contemplative mental practice can increase HBPa. In the context of a 9-month mental training study, the ReSource Project, two matched cohorts (n = 77 and n = 79) underwent three training modules of 3 months' duration that targeted attentional and interoceptive abilities (Presence module), socio-affective (Affect module), and socio-cognitive (Perspective module) abilities...
December 7, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27913467/transplantation-for-bone-marrow-failure-current-issues
#2
Régis Peffault de Latour
The preferred treatment of idiopathic aplastic anemia (AA) is allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)-identical sibling donor. Transplantation from a well-matched unrelated donor (MUD) may be considered for patients without a sibling donor after failure of immunosuppressive therapy, as may alternative transplantation (mismatched, cord blood or haplo-identical HSCT) for patients without a MUD. HSCT may also be contemplated for congenital disorders in cases of pancytopenia or severe isolated cytopenia...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27910750/antiretroviral-agents-looking-for-the-best-possible-chemotherapeutic-options-to-conquer-hiv
#3
Tahir Farooq, Arruje Hameed, Kanwal Rehman, Muhammad Ibrahim, Muhammad Imran Qadir, Muhammad Sajid Hamid Akash
For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to chronic conditions. However, many challenges, like emergence of drug resistance, limited the scope of activity of currently existing anti-HIV agents. Quite often severe side effects and lifelong dependency are the major concerns of present era. All these issues have compelled the scientists to reconsider and refine the current therapies and also contemplate the pivotal priorities for the developments of novel therapeutic paradigms...
2016: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/27909417/defining-contemplative-science-the-metacognitive-self-regulatory-capacity-of-the-mind-context-of-meditation-practice-and-modes-of-existential-awareness
#4
Dusana Dorjee
The term 'contemplative' is now frequently used in the fast growing field of meditation research. Yet, there is no consensus regarding the definition of contemplative science. Meditation studies commonly imply that contemplative practices such as mindfulness or compassion are the subject of contemplative science. Such approach, arguably, contributes to terminological confusions in the field, is not conducive to the development of an overarching theory in contemplative science, and overshadows its unique methodological features...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27906521/modeling-the-human-scarred-heart-in-vitro-toward-new-tissue-engineered-models
#5
Janine C Deddens, Amir Hossein Sadeghi, Jesper Hjortnaes, Linda W van Laake, Marc Buijsrogge, Pieter A Doevendans, Ali Khademhosseini, Joost P G Sluijter
Cardiac remodeling is critical for effective tissue healing, however, excessive production and deposition of extracellular matrix components contribute to scarring and failing of the heart. Despite the fact that novel therapies have emerged, there are still no lifelong solutions for this problem. An urgent need exists to improve the understanding of adverse cardiac remodeling in order to develop new therapeutic interventions that will prevent, reverse, or regenerate the fibrotic changes in the failing heart...
December 1, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27898526/uptake-of-hiv-pre-exposure-prophylaxis-prep-in-a-national-cohort-of-gay-and-bisexual-men-in-the-united-states-the-motivational-prep-cascade
#6
Jeffrey T Parsons, H Jonathon Rendina, Jonathan M Lassiter, Thomas H F Whitfield, Tyrel J Starks, Christian Grov
OBJECTIVES: The HIV care cascade provides milestones to track the progress of HIV-positive people from seroconversion through viral suppression. We propose a Motivational PrEP Cascade involving five stages based upon the Transtheoretical Model of Change. METHODS: We analyzed data from 995 men in One Thousand Strong, a longitudinal study of a national panel of HIV-negative gay and bisexual men in the United States. RESULTS: Nearly all (89%) participants were sexually active in the past 3 months, and 65% met CDC criteria for PrEP candidacy...
November 24, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27892851/lovastatin-fails-to-improve-motor-performance-and-survival-in-methyl-cpg-binding-protein2-null-mice
#7
Claudia Villani, Giuseppina Sacchetti, Renzo Bagnati, Alice Passoni, Federica Fusco, Mirjana Carli, Roberto William Invernizzi
Previous studies provided evidence for the alteration of brain cholesterol homeostasis in 129.Mecp2-null mice, an experimental model of Rett syndrome. The efficacy of statins in improving motor symptoms and prolonging survival of mutant mice suggested a potential role of statins in the therapy of Rett syndrome. In the present study, we show that Mecp2 deletion had no effect on brain and reduced serum cholesterol levels and lovastatin (1.5 mg/kg, twice weekly as in the previous study) had no effects on motor deficits and survival when Mecp2 deletion was expressed on a background strain (C57BL/6J; B6) differing from that used in the earlier study...
November 28, 2016: ELife
https://www.readbyqxmd.com/read/27891011/excessive-dynamic-airway-collapse-and-wheeze-reasons-for-contemplation
#8
Animesh Ray
No abstract text is available yet for this article.
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27890302/-facilitators-and-barriers-regarding-end-of-life-care-at-nursing-homes-a-focus-group-study
#9
María Remedios Sánchez-García, Marina Moreno-Rodríguez, César Hueso-Montoro, Concepción Campos-Calderón, Ana Varella-Safont, Rafael Montoya-Juárez
AIM: To identify the facilitators and barriers experienced by professional related to end of life care in nursing homes. DESIGN: Descriptive qualitative research with phenomenological orientation, through content analysis. PLACEMENT: Nursing Homes at Primary Care District in Granada (Spain). PARTICIPANTS: Fifteen clinical professionals with, at least 6 months of experience in nursing homes, without specific background in palliative care...
November 24, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27881742/association-of-abnormal-metatarsal-parabola-with-second-metatarsophalangeal-joint-plantar-plate-pathology
#10
Adam E Fleischer, Erin E Klein, Maheen Ahmad, Shivang Shah, Fernanda Catena, Lowell Scott Weil, Lowell Weil
BACKGROUND: Plantar plate pathology is common, yet it is unclear whether, and to what extent, the length of the second metatarsal contributes to this problem. METHODS: We conducted a retrospective case-control (1:2) study to examine radiographic risk factors for plantar plate tears. One hundred patients (age 55.7 ± 12.3 years) with plantar plate injuries and 200 healthy controls (age 56.3 ± 11.3 years) were included. Cases were defined as patients with nonacute, isolated, plantar plate pathology of the second metatarsophalangeal joint confirmed by intraoperative inspection at a single foot and ankle specialty practice from June 1, 2007, to January 31, 2014...
November 22, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27866675/hemodynamics-of-patient-specific-aorta-pulmonary-shunt-configurations
#11
Senol Piskin, H Firat Altin, Okan Yildiz, Ihsan Bakir, Kerem Pekkan
Optimal hemodynamics in aorta-pulmonary shunt reconstruction is essential for improved post-operative recovery of the newborn congenital heart disease patient. However, prior to in vivo execution, the prediction of post-operative hemodynamics is extremely challenging due to the interplay of multiple confounding physiological factors. It is hypothesized that the post-operative performance of the surgical shunt can be predicted through computational blood flow simulations that consider patient size, shunt configuration, cardiac output and the complex three-dimensional disease anatomy...
November 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27861500/development-of-a-tool-to-stage-households-readiness-to-change-dietary-behaviours-in-kerala-india
#12
Meena Daivadanam, T K Sundari Ravindran, K R Thankappan, P S Sarma, Rolf Wahlström
Dietary interventions and existing health behaviour theories are centred on individuals; therefore, none of the available tools are applicable to households for changing dietary behaviour. The objective of this pilot study was to develop a practical tool that could be administered by community volunteers to stage households in rural Kerala based on readiness to change dietary behaviour. Such a staging tool, comprising a questionnaire and its algorithm, focusing five dietary components (fruits, vegetables, salt, sugar and oil) and households (rather than individuals), was finalised through three consecutive pilot validation sessions, conducted over a four-month period...
2016: PloS One
https://www.readbyqxmd.com/read/27855425/prostitution-as-a-psychiatric-situation-ethical-aspects
#13
Danijela Tiosavljević, Slavica Djukić-Dejanović, Karel Turza, Aleksandar Jovanović, Vida Jeremić
This paper presents the morally controversial phenomenon of prostitution. As the basis for contemplating the prostitution issue the most important is revealing and understanding its primitive ethical root. For understanding its "soul", its essence, also important is comprehending sexual, "elementary thoughts" of mankind, through the relationship between prostitution and religious, social, political and spiritual life, and its nature as a reflection of the sexual-ethical concepts in different epochs and nations...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27855267/laparoscopic-total-caudate-lobectomy-for-hepatocellular-carcinoma
#14
Kit-Man Ho, Ho-Seong Han, Yoo-Seok Yoon, Jai Young Cho, Young Rok Choi, Jae Seong Jang, Seong Uk Kwon, Sungho Kim, Jang Kyu Choi
BACKGROUND: Caudate lobe is located in the deep dorsal area of the liver between the portal triad and the inferior vena cava (IVC). Torrential bleeding can occur from the IVC and short hepatic veins during dissection. Isolated total caudate lobe resection is still rare and technically demanding. We herein present a video on the technical aspect of laparoscopic total caudate lobectomy. METHOD: A 61-year-old woman was admitted for recurrent hepatocellular carcinoma detected on imaging...
November 17, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27849142/a-multicenter-study-of-surrogate-decision-makers-experiences-in-being-approached-for-consent-for-patient-participation-in-research
#15
Karen E A Burns, Clara Juando Prats, Maria Maione, Mary Lanceta, Celia Zubrinich, Lianne Jeffs, Orla M Smith
RATIONALE: Recruitment in critical care research differs from other contexts in important ways: patients lack decision-making capacity, uncertainty exits regarding patient's prognosis, and critical illnesses are often associated with appreciable morbidity and mortality. OBJECTIVES: We aimed to describe surrogate decision makers (SDMs) experiences in being approached for consent for critically ill patients to participate in research. METHODS: A multicenter qualitative study involving 26 SDMs at 5 Canadian centers nested within a multicenter observational study of research recruitment practices...
November 16, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27834926/p53-proteoforms-and-intrinsic-disorder-an-illustration-of-the-protein-structure-function-continuum-concept
#16
REVIEW
Vladimir N Uversky
Although it is one of the most studied proteins, p53 continues to be an enigma. This protein has numerous biological functions, possesses intrinsically disordered regions crucial for its functionality, can form both homo-tetramers and isoform-based hetero-tetramers, and is able to interact with many binding partners. It contains numerous posttranslational modifications, has several isoforms generated by alternative splicing, alternative promoter usage or alternative initiation of translation, and is commonly mutated in different cancers...
November 10, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27833570/phenotypic-dimensions-of-spirituality-implications-for-mental-health-in-china-india-and-the-united-states
#17
Clayton H McClintock, Elsa Lau, Lisa Miller
While the field of empirical study on religion and spirituality in relation to mental health has rapidly expanded over the past decade, little is known about underlying dimensions of spirituality cross-culturally conceived. We aimed to bridge this gap by inductively deriving potential universal dimensions of spirituality through a large-scale, multi-national data collection, and examining the relationships of these dimensions with common psychiatric conditions. Five-thousand five-hundred and twelve participants from China, India, and the United States completed a two-hour online survey consisting of wide-ranging measures of the lived experience of spirituality, as well as clinical assessments...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27830999/the-potential-role-of-hematocrit-control-on-symptom-burden-among-polycythemia-vera-patients-insights-from-the-cyto-pv-and-mpn-saf-patient-cohorts
#18
Robyn Marie Scherber, Holly Lynn Geyer, Amylou C Dueck, Heidi E Kosiorek, Guido Finazzi, Riccardo Cavazzina, Arianna Masciulli, Marco Scarano, Alessandro M Vannucchi, Ruben A Mesa, Tiziano Barbui
Current guidelines suggest that polycythemia vera (PV) patients maintain a strict hematocrit less than 45%. However, to date, little is known about the relationship between HCT control and PV- related symptom burden. In this study, PV patient data was analyzed from the CYTO PV trial (n = 224) and the MPN-SAF study cohort (n = 645). No significant differences in symptom burden were seen at the 6 and 12 month follow-up when evaluating prospective hematocrit control in the CYTO PV cohort. Patients in the MPN-SAF cohort with a worst item score of greater than 5/10 on the Myeloproliferative Neoplasm Symptom Total Symptom Score had a significantly lower mean hematocrit (p = ...
November 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27826821/flash-flood-susceptibility-analysis-and-its-mapping-using-different-bivariate-models-in-iran-a-comparison-between-shannon-s-entropy-statistical-index-and-weighting-factor-models
#19
Khabat Khosravi, Hamid Reza Pourghasemi, Kamran Chapi, Masoumeh Bahri
Flooding is a very common worldwide natural hazard causing large-scale casualties every year; Iran is not immune to this thread as well. Comprehensive flood susceptibility mapping is very important to reduce losses of lives and properties. Thus, the aim of this study is to map susceptibility to flooding by different bivariate statistical methods including Shannon's entropy (SE), statistical index (SI), and weighting factor (Wf). In this regard, model performance evaluation is also carried out in Haraz Watershed, Mazandaran Province, Iran...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27823698/a-critical-reappraisal-of-aspirin-for-secondary-prevention-in-patients-with-ischemic-heart-disease
#20
REVIEW
Robert C Welsh, Matthew T Roe, Philippe Gabriel Steg, Stefan James, Thomas J Povsic, Christoph Bode, Charles Michael Gibson, Erik Magnus Ohman
Aspirin was established more than a quarter century ago as an evidence-based therapy to reduce recurrent cardiovascular events in patients with coronary artery disease based on limited data by contemporary standards. Indeed it is unclear how regulatory agencies would define the optimal dose or duration of aspirin therapy if assessed in the current era. Subsequent clinical investigation has focused on the addition of antithrombotic agents on top of baseline aspirin therapy in the acute and chronic setting to reduce patient's risk of further ischemic events, at the cost of increased bleeding complications...
November 2016: American Heart Journal
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