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https://www.readbyqxmd.com/read/28635544/heparin-new-life-for-an-old-drug
#1
Carlos Raúl Aláez-Versón, Elena Lantero, Xavier Fernàndez-Busquets
Heparin is one of the oldest drugs, which nevertheless remains in widespread clinical use as an inhibitor of blood coagulation. The history of its identification a century ago unfolded amid one of the most fascinating scientific controversies turning around the distribution of credit for its discovery. The composition, purification and structure-function relationship of this naturally occurring glycosaminoglycan regarding its classical role as anticoagulant will be dealt with before proceeding to discuss its therapeutic potential in, among other, inflammatory and infectious disease, cancer treatment, cystic fibrosis and Alzheimer's disease...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635364/the-impact-of-motivational-interviewing-on-behavior-stages-of-nulliparous-pregnant-women-preparing-for-childbirth-a-randomized-clinical-trial
#2
Masoumeh Rasouli, Seyed Abbas Mousavi, Ahmad Khosravi, Afsaneh Keramat, Ensieh Fooladi, Giti Atashsokhan
OBJECTIVE: To examine the effectiveness of motivational interviewing (MI) on the stages of behavior change among nulliparous pregnant women who were preparing for childbirth. METHODS: In this randomized clinical trial, 234 pregnant women were studied in two intervention groups (MI and lecture), and one control group at three stages. In weeks 16-19 of pregnancy, two counseling sessions were held for the MI group, and one lecturing session was held for the lecture group...
June 21, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28634486/%C3%AE-cell-replacement-strategies-the-increasing-need-for-a-%C3%AE-cell-dogma
#3
REVIEW
Andhira Vieira, Noémie Druelle, Fabio Avolio, Tiziana Napolitano, Sergi Navarro-Sanz, Serena Silvano, Patrick Collombat
Type 1 diabetes is an auto-immune disease resulting in the loss of pancreatic β-cells and, consequently, in chronic hyperglycemia. Insulin supplementation allows diabetic patients to control their glycaemia quite efficiently, but treated patients still display an overall shortened life expectancy and an altered quality of life as compared to their healthy counterparts. In this context and due to the ever increasing number of diabetics, establishing alternative therapies has become a crucial research goal. Most current efforts therefore aim at generating fully functional insulin-secreting β-like cells using multiple approaches...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28633372/farmer-suicides-a-qualitative-study-from-australia
#4
M Perceval, K Kõlves, P Reddy, D De Leo
Background: Farmers in Australia, in general, have poorer health outcomes, including higher rates of suicide. Aims: To investigate risk and protective factors and attitudes towards suicide and help-seeking among farmers living and working in New South Wales and Queensland in Australia. Methods: A qualitative study in which three farming sites were selected in each state to represent an area with a suicide rate equal to, below and above the state average...
June 14, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28629275/applying-learning-theory-to-safety-and-health-training-for-hispanic-immigrant-dairy-workers
#5
Patricia M Juárez-Carrillo, Amy K Liebman, Iris Anne C Reyes, Yurany V Ninco Sánchez, Matthew C Keifer
We designed a safety and health curriculum for dairy immigrant workers aiming to increase knowledge, encourage safe behavior, and reduce worker communication inequalities to prevent occupational injury and diseases. The design is largely based on the Taxonomy of Significant Learning and incorporated behavioral and adult learning theories and principles of occupational hazard control. Trainings were implemented with 836 Spanish-speaking workers from 67 farms in Wisconsin. Sixty-seven percent of workers reported never being trained before in dairy safety, 65% of these worked in dairy for 5 or fewers years, and 26% of workers reported being ever injured while working on dairy...
July 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28624108/modification-of-immunosuppressive-therapy-as-risk-factor-for-complications-after-liver-transplantation
#6
REVIEW
Paolo De Simone, Paola Carrai, Laura Coletti, Davide Ghinolfi, Stefania Petruccelli, Franco Filipponi
Management of complications post-liver transplantation (LT) includes immunosuppressive manipulations with the aim to reduce the overall burden of immunologic suppression and compensate for renal, cardiovascular, metabolic toxicities, and for the increased oncologic risk. Two approaches can be implemented to reduce immunosuppression-related adverse events: upfront schedules tailored to the pretransplant individual patient's risk profile versus downstream modifications in the event of immunosuppression-related complications...
April 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28623789/linking-pan-european-data-to-the-local-scale-for-decision-making-for-global-change-and-water-scarcity-within-water-resources-planning-and-management
#7
Sara Suárez-Almiñana, María Pedro-Monzonís, Javier Paredes-Arquiola, Joaquín Andreu, Abel Solera
This study focuses on a novel type of methodology which connects Pan-European data to the local scale in the field of water resources management. This methodology is proposed to improve and facilitate the decision making within the planning and management of water resources, taking into account climate change and its expected impacts. Our main point of interest is focused on the assessment of the predictability of extreme events and their possible effects, specifically droughts and water scarcity. Consequently, the Júcar River Basin was selected as the case study, due to the ongoing water scarcity problems and the last drought episodes suffered in the Mediterranean region...
June 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28620675/sphincter-preserving-surgery-for-low-rectal-cancers-incidence-and-risk-factors-for-permanent-stoma
#8
Joanna Chung Kiu Mak, Dominic Chi Chung Foo, Rockson Wei, Wai Lun Law
BACKGROUND: Advances in surgical techniques and paradigm changes in rectal cancer treatment have led to a drastic decline in the abdominoperineal resection rate, and sphincter-preserving operation is possible in distal rectal cancer. OBJECTIVE: The aim of this study is to evaluate the long-term incidence of permanent stoma after sphincter-preserving surgery for low rectal cancer and its corresponding risk factors. METHOD: From 2000 to 2014, patients who underwent sphincter-preserving low anterior resection for low rectal cancer (within 5 cm from the anal verge) were included...
June 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28618885/an-exploration-of-current-approaches-to-and-facilities-for-spiritual-care-provision-in-the-republic-of-ireland
#9
Fiona Timmins, Sílvia Caldeira, Maryanne Murphy, Nicolas Pujol, Greg Sheaf, Elizabeth Weathers, Jacqueline Whelan, Bernadette Flanagan
This study aimed to explore current approaches to and facilities for spiritual care provision in the Republic of Ireland. The findings identify that providing spiritual care to patients is a key component of hospital policy. Spiritual support is identified as the responsibility of the whole healthcare team with specific responsibility being attributed to the healthcare chaplain. Most sites provided a sacred space or quiet place for clients, visitors and staff to contemplate.
June 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/28618880/contemplative-listening-in-moral-issues-moral-counseling-redefined-in-principles-and-method
#10
Jack de Groot, Maria E C van Hoek
We present a listening grid for moral counseling, in which we pay particular attention, alongside the what, to how clients talk about themselves: as if they were spectators; aware what this talking does to them; how they perceive what is good from the past; and what they will strive for in the future. By this moral talk, clients discover a picture of the conviction that will enable them to make a decision.
June 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/28618879/contemplative-listening-a-rhetorical-critical-approach-to-facilitate-internal-dialog
#11
Hans Evers
This article presents a discussion technique that is tailored to clients needing to reorient their convictions following a critical life event. The technique has three distinctive characteristics. The client's statements are not classified into categories from conventional layer models that are designed to track the themes or content of talk. Instead, we adopt a rhetorical approach because of the fundamental metaphysical nature of conviction that this article assumes. The primary focus is on how clients talk about themselves and their convictions...
June 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/28615754/telepsychiatry-in-india-where-do-we-stand-a-comparative-review-between-global-and-indian-telepsychiatry-programs
#12
REVIEW
Subrata Naskar, Robin Victor, Himabrata Das, Kamal Nath
A wide discrepancy exists in India between the existing mental healthcare repertoire and the alarmingly high burden of individuals requiring immediate attention from requisite mental healthcare services. Providing equitable mental healthcare across a vast country characterized by profound cultural variations and territorial caveats has remained a major public health concern. Against this gloomy backdrop, the emergence of distant communications technology offers solace and optimism as an ingenious approach to bridge the existing gap between clients and mental health professionals...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28612325/stages-of-change-for-mammography-among-mexican-women-and-a-decisional-balance-comparison-across-countries
#13
Ana María Salinas-Martínez, David Emmanuel Castañeda-Vásquez, Norma Guadalupe García-Morales, Norma Edith Oliva-Sosa, Laura Hermila de-la-Garza-Salinas, Georgina Mayela Núñez-Rocha, José Manuel Ramírez-Aranda
An analysis of the adoption of secondary preventive behaviors is significant in regions with disparities in mammography use and breast cancer survival. Therefore, we determined the cognitive factors and the degree to which they differentiate stages of change in mammography among Mexican women. We also compared the decisional balance performance at Mexico, Switzerland, South Korea, and the USA. A cross-sectional study was designed for women in the stages of precontemplation (n = 240), contemplation (n = 243), action (n = 205), maintenance (n = 311), and relapse (n = 348)...
June 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28606411/can-parasitic-worms-cure-the-modern-world-s-ills
#14
REVIEW
Margaret M Harnett, William Harnett
There has been increasing recognition that the alarming surge in allergy and autoimmunity in the industrialised and developing worlds shadows the rapid eradication of pathogens, such as parasitic helminths. Appreciation of this has fuelled an explosion in research investigating the therapeutic potential of these worms. This review considers the current state-of-play with a particular focus on exciting recent advances in the identification of potential novel targets for immunomodulation that can be exploited therapeutically...
June 9, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28606335/atr-ftir-characterization-of-generic-brand-named-and-counterfeit-sildenafil-and-tadalafil-based-tablets-found-on-the-brazilian-market
#15
José Coelho Neto, Fernanda L C Lisboa
Viagra and Cialis are among the most counterfeited medicines in many parts of the world, including Brazil. Despite the many studies that have been made regarding discrimination between genuine and counterfeit samples, most published works do not contemplate generic and similar versions of these medicines and also do not explore excipients/adjuvants contributions when characterizing genuine and suspected samples. In this study, we present our findings in exploring ATR-FTIR spectral profiles for characterizing both genuine and questioned samples of several generic and brand-name sildenafil- and tadalafil-based tablets available on the Brazilian market, including Viagra and Cialis...
July 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28602837/a-review-on-epidemiology-global-prevalence-and-economical-losses-of-fasciolosis-in-ruminants
#16
REVIEW
Khalid Mehmood, Hui Zhang, Ahmad Jawad Sabir, Rao Zahid Abbas, Muhammad Ijaz, Aneela Zameer Durrani, Muhammad Hassan Saleem, Mujeeb Ur Rehman, Muhammad Kashif Iqbal, Yajing Wang, Hafiz Ishfaq Ahmad, Tariq Abbas, Riaz Hussain, Muhammad Taslim Ghori, Sadaqat Ali, Aman Ullah Khan, Jiakui Li
Fasciolosis is an important plant borne trematode zoonosis in ruminants caused by the Fasciola hepatica and Fasciola gigentica, It is classified as a neglected tropical disease and found in more than 50 countries especially where sheep and cattle are reared. Fasciolosis is a serious animal health problems in many rural and urban areas of world, causing significant financial losses due to decrease in production and viscera condemnation in animals. Accurate diagnosis of fasciolosis is always remained a challenging task for the field practitioners...
June 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28601589/sharpsports-mental-health-awareness-research-project-prevalence-and-risk-factors-of-depressive-symptoms-and-life-stress-in-elite-athletes
#17
Sarah Beable, Mark Fulcher, Arier C Lee, Bruce Hamilton
OBJECTIVES: Our study aims to estimate the prevalence of symptoms of depression and daily life hassles in elite athletes. DESIGN: A cross-sectional prospective epidemiological study design. METHODS: An online anonymous survey was administered during a 2-month period from May to July 2015. Athletes 18 years of age (or older) who were members of the High Performance Sport New Zealand programme were invited to participate. Of 370 potential participants, 187 completed responses were received (51%)...
May 17, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28598975/vitamin-d-deficiency-and-clinical-correlations-in-systemic-sclerosis-patients-a-retrospective-analysis-for-possible-future-developments
#18
Amelia Chiara Trombetta, Vanessa Smith, Emanuele Gotelli, Massimo Ghio, Sabrina Paolino, Carmen Pizzorni, Amber Vanhaecke, Barbara Ruaro, Alberto Sulli, Maurizio Cutolo
OBJECTIVE: Assessment of serum 25-hydroxyvitamin D (25(OH)D) correlations with clinical parameters and evaluation of the efficacy of standard oral supplementation in systemic sclerosis (SSc) patients. METHODS: 154 SSc patients were recruited, in all seasons. Serum 25(OH)D concentrations were evaluated using LIAISON 25-OH (Diasorin, Italy). Medsger disease severity scale (DSS), nailfold videocapillaroscopy (NVC) and all instrumental exam contemplated by international guidelines were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28592393/enhancing-the-autonomy-of-indian-nurses
#19
Meena Putturaj, N S Prashanth
With additional training and qualification, nurses in several countries are recognised as independent professionals. Evidence from several countries shows that capacitating nurses to practise independently could contribute to better health outcomes. Recently, the idea of nurses practising independently has been gaining momentum in Indian health policy circles as well, and the Ministry of Health and Family Welfare is contemplating the introduction of nurse practitioners (NPs) in primary healthcare. We briefly assess the policy environment for the role of NPs in India...
May 30, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28591295/associations-between-frailty-syndrome-and-sociodemographic-characteristics-in-long-lived-individuals-of-a-community
#20
Clóris Regina Blanski Grden, Maria Helena Lenardt, Jacy Aurelia Vieira de Sousa, Luciana Kusomota, Mara Solange Gomes Dellaroza, Susanne Elero Betiolli
Objective: investigating the association between frailty syndrome and sociodemographic characteristics in long-lived individuals of a community. Method: a cross-sectional study with a proportional stratified sample consisting of 243 long-lived individuals. A structured instrument, scales and tests that comprise evaluating frailty were applied for data collection. Univariate and multivariate analyzes were performed by logistic regression (p<0.05) by Statistica 10(r) software and Odds Ratio (95% Confidence Interval) were calculated for the predictive models...
June 5, 2017: Revista Latino-americana de Enfermagem
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