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Anna Giardini, Marina Maffoni, Przemyslaw Kardas, Elisio Costa
Worldwide, the population is aging and this trend will increase in the future due to medical, technological and scientific advancements. To take care of the elderly is highly demanding and challenging for the health care system due to their frequent condition of chronicity, multimorbidity and the consequent complex management of polypharmacy. Nonadherence to medications and to medical plans is a well-recognized public health problem and a very urgent issue in this population. For this reason, some considerations to identify a new shared approach to integrated care of older people are described...
2018: Patient Preference and Adherence
Medha Anand Bhave
Context: Seroma formation is a common complication after lipoabdominoplasty. Conventionally, drains have been placed to prevent seroma; however, there are problems with drains, namely, pain, compromised mobilisation, breakage, tissue irritation and infection. Strategies to prevent seroma, such as the use of glue or quilting sutures have all been attempted with variable and unpredictable benefit. Aims: The author extrapolated the experience with own liposuction protocols to lipoabdominoplasty and began doing away with drains from the year 2006 onwards unless absolutely indicated...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Talita Candida Castro, Luciana Schleder Gonçalves
OBJECTIVES: To investigate whether the course offer with elements of gamification contributes to the formation of competences in Informatics in Nursing; and evaluate it based on teaching and learning criteria and content structure. METHOD: Exploratory, applied and technological innovation research, with a qualitative and quantitative approach, developed at a university in the southern region of the country between February and November 2016. Participants were professors (5) and nursing students (10)...
May 2018: Revista Brasileira de Enfermagem
T Noblet, J Marriot, T Jones, C Dean, A Rushton
BACKGROUND: Non-medical prescribing (NMP) is acknowledged as an expanding area of clinical practice across the world. The physiotherapy profession is currently investigating the introduction of physiotherapist prescribing in Australia, with the case for reform centred around meeting the healthcare needs of the current and future Australian population. Conflict within a profession has been identified as a barrier to implementation of new clinical innovations. An online survey has been developed with the aim to collect and synthesise the views and perceptions of Australian physiotherapists and physiotherapy students about the potential use of NMP by physiotherapists in Australia...
June 19, 2018: BMC Health Services Research
Lida Fotouhi, Majid M Heravi, Vahideh Zadsirjan, Paria Asadi Atoi
Due to its high potential for the formation of carbon-carbon bonds, Michael addition reaction is one of the closest reactions to the heart of synthetic organic chemists. Electrochemistry presents a very stimulating and divergent resource for selective oxidation and reduction in organic chemistry, generating activated species, for example radical anions or radical cations. In this review, we try to underscore usefulness of electrogenerated Michael addition reaction with the hope of encouraging synthetic organic chemists to contemplate it, as an efficient and green strategy when it is required in their designed multi-step reaction pathways...
June 19, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Magdalena Skowronski, Mette Bech Risør, Rikke Sand Andersen, Nina Foss
Little is known about how people living in the aftermath of cancer treatment experience and manage worries about possible signs of cancer relapse, not as an individual enterprise but as socially embedded management. One-year ethnographic fieldwork was conducted in a coastal village of under 3000 inhabitants in northern Norway. Ten villagers who had undergone cancer treatment from six months to five years earlier were the main informants. During fieldwork, the first author conducted qualitative, semi-structured monthly interviews with them, and participated in their everyday activities and relationships, including families, friends and co-villagers...
June 18, 2018: Anthropology & Medicine
José Paulo Couto, Ricardo Moreira
Obsessive-compulsive disorder (OCD) is characterized by the presence of obsessions and/or compulsions. It is a leading cause of morbidity worldwide, as it can interfere with all aspects of life. Despite the adequate treatment trials, half of patients preserve residual or impairing symptoms and selective serotonin reuptake inhibitors (SSRIs) are not free from adverse side effects. This work aims to systematically review the current evidence available concerning the efficacy of N-acetylcysteine (NAC) in the treatment of OCD...
June 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Allan R Vieira, Celia Anteneodo
We introduce the threshold q-voter opinion dynamics where an agent, facing a binary choice, can change its mind when at least q_{0} among q neighbors share the opposite opinion. Otherwise, the agent can still change its mind with a certain probability ɛ. This threshold dynamics contemplates the possibility of persuasion by an influence group even when there is not full agreement among its members. In fact, individuals can follow their peers not only when there is unanimity (q_{0}=q) in the lobby group, as assumed in the q-voter model, but also, depending on the circumstances, when there is simple majority (q_{0}>q/2), Byzantine consensus (q_{0}>2q/3), or any minimal number q_{0} among q...
May 2018: Physical Review. E
Boris M Velichkovsky, Olga A Krotkova, Artemy A Kotov, Vyacheslav A Orlov, Vitaly M Verkhlyutov, Vadim L Ushakov, Maxim G Sharaev
By taking into account Bruce Bridgeman's interest in an evolutionary framing of human cognition, we examine effective (cause-and-effect) connectivity among cortical structures related to different parts of the triune phylogenetic stratification: archicortex, paleocortex and neocortex. Using resting-state functional magnetic resonance imaging data from 25 healthy subjects and spectral Dynamic Causal Modeling, we report interactions among 10 symmetrical left and right brain areas. Our results testify to general rightward and top-down biases in excitatory interactions of these structures during resting state, when self-related contemplation prevails over more objectified conceptual thinking...
June 11, 2018: Consciousness and Cognition
Kamalika Sen, Dhananjay Bhattacharyya, Arijita Sarkar, Jyotirmoy Das, Nilanjana Maji, Moitri Basu, Zhumur Ghosh, Tapash Chandra Ghosh
BACKGROUND: Human Chronic and Acute Myeloid Leukemia are myeloproliferative disorders in myeloid lineage of blood cells characterized by accumulation of aberrant white blood cells. In cancer, the anomalous transcriptome includes deregulated expression of non-coding RNAs in conjunction with protein-coding mRNAs in human genome. The coding or non-coding RNA transcripts harboring miRNA-binding sites can converse with and regulate each other by explicitly contending for a limited pool of shared miRNAs and act as competitive endogenous RNAs (ceRNAs)...
June 11, 2018: Biochimica et Biophysica Acta
Abdulrahman AlDarrab, Rizwan Malik
Aniridia-associated glaucoma is often refractory to medical treatment. Glaucoma drainage device surgery is often considered after failed angle surgery. However, the potential complications of tube surgery in young children are not negligible. The failure rate of conventional trabeculectomy may be high and can require close and multiple postoperative follow-up visits. Here, we describe a child with aniridia who achieved good short-term results with deep sclerectomy. A 14-month-old girl was referred to our unit following bilateral trabeculotomies for aniridia-associated glaucoma and persistent uncontrolled intraocular pressure (IOP) in both eyes...
January 2018: Middle East African Journal of Ophthalmology
Åsa Alftberg, Gerd Ahlström, Per Nilsen, Lina Behm, Anna Sandgren, Eva Benzein, Birgitta Wallerstedt, Birgit H Rasmussen
Nursing homes are often places where older persons “come to die.” Despite this, death and dying are seldom articulated or talked about. The aim of this study was to explore assistant nurses’ experiences of conversations about death and dying with nursing home residents. This study is part of an implementation project through a knowledge-based educational intervention based on palliative care principles. An ethnographic study design was applied in seven nursing homes, where eight assistant nurses were interviewed and followed in their daily assignments through participant observations...
June 14, 2018: Healthcare (Basel, Switzerland)
Elena Bozzola, Giulia Spina, Rocco Russo, Mauro Bozzola, Giovanni Corsello, Alberto Villani
BACKGROUND: High rates of vaccination coverage are important in preventing infectious diseases. Enforcing mandatory vaccinations is one of the strategies that some Countries adopted to protect the community when vaccination coverage is not satisfactory. In Italy, in 2017 vaccination against diphtheria, tetanus, pertussis, hepatitis B, poliovirus, Haemophilus influenzae type b, measles, mumps, rubella and varicella became compulsory in childhood. In order to contrast vaccination policies, anti-vaccination campaigns contribute to the spread of fake news...
June 14, 2018: Italian Journal of Pediatrics
Junaid Ashraf, Jamie Krishnan, Alexander Turner, Ramnath Subramaniam
PURPOSE: The learning curve is an important method of assessment of progression in the use of a new technique or device and, in the field of robotic surgery, is most commonly described for individual procedures, often concentrating on console time and outcomes. We contemplated whether a learning curve of the similar nature and duration was exhibited in the procedure-independent variable of docking time. MATERIALS AND METHODS: The time from first incision to end of robot docking was found for a single surgeon's first 55 robotic cases, which encompassed a range of pediatric urological procedures...
June 13, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Reilly N Grant, David Kucher, Ana M León, Jonathan F Gemmell, Daniela S Raicu, Samah J Fodeh
BACKGROUND: Suicide is an alarming public health problem accounting for a considerable number of deaths each year worldwide. Many more individuals contemplate suicide. Understanding the attributes, characteristics, and exposures correlated with suicide remains an urgent and significant problem. As social networking sites have become more common, users have adopted these sites to talk about intensely personal topics, among them their thoughts about suicide. Such data has previously been evaluated by analyzing the language features of social media posts and using factors derived by domain experts to identify at-risk users...
June 13, 2018: BMC Bioinformatics
Sabrina A Hogan, Mitchell P Levesque, Phil F Cheng
The recent emergence of cancer immunotherapies initiated a significant shift in the clinical management of metastatic melanoma. Prior to 2011, melanoma patients only had palliative treatment solutions which offered little to no survival benefit. In 2018, with immunotherapy, melanoma patients can now contemplate durable or even complete remission. Treatment with novel immune checkpoint inhibitors, anti-cytotoxic T-lymphocyte protein 4 and anti-programmed cell death protein 1, clearly result in superior median and long-term survivals compared to standard chemotherapy; however, more than half of the patients do not respond to immune checkpoint blockade...
2018: Frontiers in Oncology
Mical Raz
In the late 1960s, Philadelphia psychiatrists evaluated every child who interacted with the city's juvenile courts. These evaluations had an important role in determining the placement and treatment of these children, and emphasized the therapeutic nature of the juvenile courts at the time. Relying on extensive case studies compiled by the Philadelphia Department of Public Welfare, this study reconstructs the roles of psychiatrists in the experiences of children interacting with the juvenile justice system, to shed light on a hitherto unknown aspect of these children's care...
June 8, 2018: Journal of the History of Medicine and Allied Sciences
Yanli Lin, Courtney P Callahan, Jason S Moser
The aim of the current review is to advance the hypothesis that change in self-referential processing is a key but under-examined mechanism through which mindfulness training confers its therapeutic benefits for individuals with internalizing disorders. Consequently, we integrated neuroscientific studies on aberrant self-referential processing in internalizing disorders with contemplative science scholarship examining the effects of mindfulness training on the self-referential system. Reviewing these literatures yielded four major conclusions: (1) internalizing disorders can be characterized by excessive self-referential processing and emotion dysregulation; (2) mindfulness training has moderate effects on reducing internalizing symptoms; (3) mindfulness training promotes the shifting from narrative self-focus to present-centered experiential awareness; (4) such mindfulness-induced changes in self-reference is accompanied by reduced activation in overactive self-referential brain regions that have been implicated in internalizing disorders...
June 7, 2018: Neuroscience and Biobehavioral Reviews
Maree O'Keefe, Helena Ward
BACKGROUND: Despite interprofessional learning (IPL) being widely recognised as important for health care professions, embedding IPL within core curriculum remains a significant challenge. The aim of this study was to identify tensions associated with implementing IPL curriculum for educators and clinical supervisors, and to examine these findings from the perspective of activity theory and the expansive learning cycle (ELC). METHODS: We interviewed 12 faculty staff and ten health practitioners regarding IPL...
June 8, 2018: BMC Medical Education
Avner Hershlag, Sara L Bristow
The rapid development of gene-editing technologies has led to an exponential rise in both basic and translational research initiatives studying molecular processes and investigating possible clinical applications. Early experiments using genome editing to study human embryo development have contradicted findings in studies on model organisms. Additionally, a series of four experiments over the past 2 years set out to investigate the possibilities of introducing genetic modifications to human embryos, each with varying levels of success...
June 7, 2018: Journal of Assisted Reproduction and Genetics
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