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Gina 2016

Matthew J Scheffel, Gina Scurti, Patricia Simms, Elizabeth Garrett-Mayer, Shikhar Mehrotra, Michael I Nishimura, Christina Voelkel-Johnson
Although adoptive transfer of autologous tumor antigen-specific T-cell immunotherapy can produce remarkable clinical efficacy, most patients do not achieve durable complete responses. We hypothesized that reducing susceptibility of T cells to activation-induced cell death (AICD), which increases during the rapid in vitro expansion of therapeutic T cells before their infusion, might improve the persistence of adoptively transferred cells. Our investigations revealed that repetitive stimulation of the T-cell receptor (TCR) induced AICD, as a result of activating the DNA damage response pathway through ATM-mediated Ser15 phosphorylation of p53...
October 15, 2016: Cancer Research
Manfred P Lutz, John R Zalcberg, Rob Glynne-Jones, Theo Ruers, Michel Ducreux, Dirk Arnold, Daniela Aust, Gina Brown, Krzysztof Bujko, Christopher Cunningham, Serge Evrard, Gunnar Folprecht, Jean-Pierre Gerard, Angelita Habr-Gama, Karin Haustermans, Torbjörn Holm, Koert F Kuhlmann, Florian Lordick, Gilles Mentha, Markus Moehler, Iris D Nagtegaal, Alessio Pigazzi, Salvatore Pucciarelli, Arnaud Roth, Harm Rutten, Hans-Joachim Schmoll, Halfdan Sorbye, Eric Van Cutsem, Jürgen Weitz, Florian Otto
No abstract text is available yet for this article.
October 4, 2016: European Journal of Cancer
Scott M Schuetze, Vanessa Bolejack, Edwin Choy, Kristen N Ganjoo, Arthur P Staddon, Warren A Chow, Hussein A Tawbi, Brian L Samuels, Shreyaskumar R Patel, Margaret von Mehren, Gina D'Amato, Kirsten M Leu, David M Loeb, Charles A Forscher, Mohammed M Milhem, Daniel A Rushing, David R Lucas, Rashmi Chugh, Denise K Reinke, Laurence H Baker
BACKGROUND: Alveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that are relatively resistant to chemotherapy and for which more effective drug therapy is needed. METHODS: The 5 listed subtypes were enrolled into a single indolent sarcoma cohort in a phase 2 study of dasatinib using a Bayesian continuous monitoring rule for enrollment. The primary objective was to estimate the 6-month progression-free survival (PFS) rate according to the Choi criteria with a target of ≥50%...
October 3, 2016: Cancer
Kristin M Maiden, Marina Kaplan, Lee Ann Walling, Patricia P Miller, Gina Crist
Comprehensive land use plans and their corresponding regulations play a role in determining the nature of the built environment and community design, which are factors that influence population health and health disparities. To determine the level in which a plan addresses healthy living and active design, there is a need for a systematic, reliable and valid method of analyzing and scoring health-related content in plans and regulations. This paper describes the development and validation of a scoring tool designed to measure the strength and comprehensiveness of health-related content found in land use plans and the corresponding regulations...
September 26, 2016: Preventive Medicine
Sarah Tidwell, Kari Hess, Gina Peek
BACKGROUND: Multiple faculty were present during a simulation for competency assessments of students, thus creating an increased workload and fatigue. Faculty used technology to reduce the workload and maintain interrater reliability, at little to no cost. METHOD: The use of high-fidelity simulators, tablet computers, and a university video platform were used to record student competency assessments. One faculty member could perform the assessment, but other course faculty could review the results...
October 1, 2016: Journal of Nursing Education
David V Walsh, Gina M Jurek, William E McLean, Jonathan K Statz, Roddricus L Allen, Daniel W Riggs
BACKGROUND: Apache pilots needing refractive correction are issued modified HGU-4/P aviator spectacles. However, a recently published survey found field of view (FOV) dissatisfaction with the current spectacles when sighting in with a Helmet Display Unit (HDU). A current Air Force flight frame was modified in-lab and the purpose of this study was to evaluate the FOV with the current Apache flight frame vs. the modified flight frame. METHODS: Recruited were 21 Apache pilots to assess FOV under three conditions: 1) wearing the current Apache frame; 2) wearing the modified Apache frame; and 3) wearing no frame...
September 2016: Aerospace Medicine and Human Performance
Hani D Freeman, Annie J Valuska, Ryan R Taylor, Gina M Ferrie, Alison P Grand, Katherine A Leighty
There is evidence that plumage coloration is related to mate choice in several different bird species. However, the relationship between plumage coloration to mate or other social partner choice has rarely been investigated in flamingos. This is important to study because we know plumage coloration can be an indicator of welfare. We assessed plumage color score in relation to sex, age, and social partner choice over a 9-month period in a flock of 34 adult greater flamingos (Phoenicopterus roseus) living at Disney's Animal Kingdom(®) ...
September 2016: Zoo Biology
Mette Rose Jørgensen, Gina Castiblanco, Svante Twetman, Mette Kirstine Keller
PURPOSE: This review summarized the available literature on the prevention of childhood caries through biofilm engineering with probiotic bacteria in early childhood. METHODS: Three databases (PubMed, Cochrane Library and Trip) were searched through January, 2016 for randomized controlled trials published in English. Out of 144 abstracts, seven studies fulfilled the predetermined inclusion criteria and were quality assessed with respect to risk of bias independently by two examiners...
June 2016: American Journal of Dentistry
Aleksandra Leligdowicz, William A Fischer, Timothy M Uyeki, Thomas E Fletcher, Neill K J Adhikari, Gina Portella, Francois Lamontagne, Christophe Clement, Shevin T Jacob, Lewis Rubinson, Abel Vanderschuren, Jan Hajek, Srinivas Murthy, Mauricio Ferri, Ian Crozier, Elhadj Ibrahima, Marie-Claire Lamah, John S Schieffelin, David Brett-Major, Daniel G Bausch, Nikki Shindo, Adrienne K Chan, Tim O'Dempsey, Sharmistha Mishra, Michael Jacobs, Stuart Dickson, G Marshall Lyon, Robert A Fowler
As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flare-ups of EVD cases in West Africa.EVD presentation is nonspecific and characterized initially by onset of fatigue, myalgias, arthralgias, headache, and fever; this is followed several days later by anorexia, nausea, vomiting, diarrhea, and abdominal pain. Anorexia and gastrointestinal losses lead to dehydration, electrolyte abnormalities, and metabolic acidosis, and, in some patients, acute kidney injury...
2016: Critical Care: the Official Journal of the Critical Care Forum
Katharine M Esselen, Angel M Cronin, Kristin Bixel, Michael A Bookman, Robert A Burger, David E Cohn, Mihaela Cristea, Jennifer J Griggs, Charles F Levenback, Gina Mantia-Smaldone, Larissa A Meyer, Ursula A Matulonis, Joyce C Niland, Charlotte Sun, David M O'Malley, Alexi A Wright
Importance: A 2009 randomized clinical trial demonstrated that using cancer antigen 125 (CA-125) tests for routine surveillance in ovarian cancer increases the use of chemotherapy and decreases patients' quality of life without improving survival, compared with clinical observation. The Society of Gynecologic Oncology guidelines categorize CA-125 testing as optional and discourage the use of radiographic imaging for routine surveillance. To date, few studies have examined the use of CA-125 tests in clinical practice...
July 21, 2016: JAMA Oncology
Michael Robbins
Formless Infinity: Clinical Explorations of Matte Blanco and Bion. By Riccardo Lombardi. Translated by Karen Christenfeld, Gina Atkinson, Andrea Sabbadini, and Philip Slotkin. London/New York: Routledge, 2016. 282 pp.
July 2016: Psychoanalytic Quarterly
Onur Turan, Pakize Ayse Turan, Arzu Mirici
AIM: One of the most significant problems in the treatment of elderly patients is incorrect use of inhaler devices. The purpose of the present study was to assess the parameters affecting treatment adherence among elderly patients. METHODS: Spirometry, the Mini-Mental State Examination for cognitive impairment and the Morisky Medication Adherence Scale-4 were carried out in 121 (88 chronic obstructive lung disease patients according to the Global Initiative for Chronic Obstructive Lung Disease, 33 asthma patients according to The Global Initiative for Asthma (GINA) criteria) participants aged over 65 years...
July 18, 2016: Geriatrics & Gerontology International
Raquel Lemos, Isabel Santana, Gina Caetano, Inês Bernardino, Ricardo Morais, Reza Farivar, Miguel Castelo-Branco
OBJECTIVES: Mild cognitive impairment (MCI) has been associated with a high risk of conversion to Alzheimer's dementia. In addition to memory complaints, impairments in the visuospatial domain have been reported in this condition. We have previously shown that deficits in perceiving structure-from-motion (SFM) objects are reflected in functional reorganization of brain activity within the visual ventral stream. Here we aimed to identify structural correlates of psychophysical complex face and object recognition performance in amnestic MCI patients (n=30 vs...
August 2016: Journal of the International Neuropsychological Society: JINS
Toby O Smith, Paul Jepson, Andrew Beswick, Gina Sands, Avril Drummond, Edward T Davis, Catherine M Sackley
BACKGROUND: Total hip arthroplasty (THA) is one of the most common orthopaedic operations performed worldwide. Painful osteoarthritis of the hip is the primary indication for THA. Following THA, people have conventionally been provided with equipment, such as raised toilet seats and chairs, and educated to avoid activities that could cause the hip joint to be in a position of flexion over 90 degrees, or adduction or rotation past the midline. These aspects of occupational therapy have been advocated to reduce the risks of prosthesis dislocation...
2016: Cochrane Database of Systematic Reviews
Ladan Afifi, Eric L Maranda, Mina Zarei, Gina M Delcanto, Leyre Falto-Aizpurua, Wouter P Kluijfhout, Joaquin J Jimenez
BACKGROUND AND OBJECTIVES: Androgenetic alopecia (AGA) affects 50% of males by age 50 and 50% of females by age 80. Recently, the use of low-level laser therapy (LLLT) has been proposed as a treatment for hair loss and to stimulate hair regrowth in AGA. This paper aims to review the existing research studies to determine whether LLLT is an effective therapy for AGA based on objective measurements and patient satisfaction. STUDY DESIGN: A systematic literature review was done to identify articles on Medline, Google Scholar, and Embase that were published between January 1960 and November 2015...
April 25, 2016: Lasers in Surgery and Medicine
Gina Boudreau, Carol Hernandez, Donna Hoffer, Kathleen Starlight Preuss, Linda Tibbetts-Barto, Nicole Toves Villaluz, Sheryl Scott
As successes mount in reducing commercial tobacco use, an alarming disparity has taken shape in Minnesota. Recent studies revealed that overall smoking rates have dropped to 14%, whereas American Indians' rates remain higher than 50%. With support from ClearWay Minnesota, the organization created from the state's tobacco settlement, advocates working within sovereign tribal governments to create smoke-free policies came together to discuss effective strategies within tribal Nations. We discussed the history behind mainstream tobacco control's failure to resonate with Native audiences and the need to reframe the movement to a goal of restoring traditional tobacco practices...
July 2016: American Journal of Public Health
Jon F Pennycuff, Stacey C Schutte, Catherine O Hudson, Deborah R Karp, Anna P Malykhina, Gina M Northington
AIMS: The aim of this study was to compare the expression of urinary nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), substance P (SP), and calcitonin-gene related peptide (CGRP) in women with and without overactive bladder (OAB). We sought to determine factors associated with higher expression of these neuropeptides. METHODS: Participants with OAB and age-matched controls were enrolled. Symptom severity was assessed with validated questionnaires...
April 6, 2016: Neurourology and Urodynamics
Melinda L Yushak, Gang Han, Sara Bouberhan, Lianne Epstein, Michael P DiGiovanna, Sarah S Mougalian, Tara B Sanft, Maysa M Abu-Khalaf, Gina G Chung, Stacey M Stein, Sarah B Goldberg, Lajos Pusztai, Erin W Hofstatter
BACKGROUND: During the process of tumor profiling, there is the potential to detect germline variants. To the authors' knowledge, there currently is no accepted standard of care for how to deal with these incidental findings. The goal of the current study was to assess disclosure preferences among patients with cancer regarding incidental genomic variants that may be discovered during tumor profiling. METHODS: A 45-item questionnaire was administered to 413 patients in ambulatory oncology clinics...
May 15, 2016: Cancer
Linda C Schanne, Sally Stern, Carol Hand, Michele Collins, Gina Kirk, Sarah Kweeder, Richard Brody, Patricia Hughes LaPorta, Donna Meehan
The demonstration of nurses' competency has been a challenge for nurse educators for a multitude of reasons. Standardizing competencies across a health care system is especially challenging. One multihospital health care system embarked on a journey to standardize and implement competencies across the system. Using a collaborative approach, the Wright model of competency assessment was selected and implemented across the system. Lessons learned include (a) the full engagement of Wright's model by all nursing stakeholders is essential, (b) indicators and outcomes must align with quality improvement data, and (c) the needs of each unit must be individualized, and the methods of verification must be closely aligned with the measurable competency...
March 2016: Journal of Continuing Education in Nursing
Gina R Petroni, Nolan A Wages, Gautier Paux, Frédéric Dubois
There has been constant development of novel statistical methods in the design of early-phase clinical trials since the introduction of model-based designs, yet the traditional or modified 3+3 algorithmic design remains the most widely used approach in dose-finding studies. Research has shown the limitations of this traditional design compared with more innovative approaches yet the use of these model-based designs remains infrequent. This can be attributed to several causes including a poor understanding from clinicians and reviewers into how the designs work, and how best to evaluate the appropriateness of a proposed design...
February 29, 2016: Statistics in Medicine
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