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https://www.readbyqxmd.com/read/28583488/non-invasive-methods-to-maintain-cervical-spine-position-after-pediatric-tracheal-resections
#1
Kahren K Aydinyan, Jonathan D Day, Gina M Troiano, G Paul Digoy
OBJECTIVES: To present our experience with two methods of neck stabilization after pediatric tracheal resection with primary anastomosis as possible alternatives to the traditional chest-chin suture. METHODS: Children undergoing tracheal resection and/or cricotracheal resection with anastomosis under tension were placed in cervical spine flexion postoperatively with either a chest-chin (Grillo) suture, an Aspen cervical collar or Trulife Johnson cervical-thoracic orthosis (CTO)...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28583262/different-prevalence-and-clinical-characteristics-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-according-to-accepted-criteria
#2
Yong Suk Jo, Jinwoo Lee, Ho Il Yoon, Deog Kyeom Kim, Chul-Gyu Yoo, Chang-Hoon Lee
BACKGROUND: A unified definition of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is not available, which makes it difficult to evaluate the prevalence and clinical features of patients with ACOS. OBJECTIVE: To investigate the prevalence and clinical characteristics of ACOS according to the updated widely accepted diagnostic criteria. METHODS: Participants were enrolled from a prospective cohort study conducted between April 2013 and November 2016 in South Korea...
June 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28554228/predictive-value-of-il-35-and-il-17-in-diagnosis-of-childhood-asthma
#3
Amira Ibrahim Mansour, Eman Rateb Abd Almonaem, Ola Galal Behairy, Tahany Mahmoud Gouda
This study aimed to evaluate the correlation between serum levels of IL-17 and IL-35 and the presence and severity of childhood asthma. The study was performed on 60 diagnosed asthmatic children, who were further classified into four groups according to the Global Initiative for Asthma Guidelines for Asthma Severity and Control (GINA) 2016, plus 30 age- and sex-matched apparently healthy children. All participants were subjected to full medical history, clinical examination, pulmonary function tests and laboratory evaluation in the form of complete blood count (CBC), serum total IgE, IL-17 and IL-35 by ELISA...
May 30, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28535631/-a-multi-center-study-for-the-association-between-the-perception-and-control-of-disease-among-asthmatic-patients-in-chinese-urban-areas
#4
Y Nong, J T Lin, W Q Wang, X Zhou, C Z Wang, M Huang, S X Cai, P Chen, Q C Lin, J Y Zhou, Y H Gu, Y D Yuan, D J Sun, X H Yang, L Yang, J M Huo, Z C Chen, P Jiang, J Zhang, X W Ye, H G Liu, H P Tang, R Y Liu, C T Liu, W Zhang, C P Hu, Y Q Chen, X J Liu, L M Dai, W Zhou, Y J Huang, J Y Xu
Objective: To investigate the current perception of disease among asthmatic patients in Chinese urban areas, and to address its association with asthma control. Methods: This was a nationwide, multi-center, cross-sectional study covering 30 third-level, grade A hospitals in 30 provinces, municipalities and autonomous regions (not including Tibet) across Chinese mainland. The survey was carried out from October 2015 to May 2016. Asthmatic outpatients were selected to receive face-to-face questionnaire survey on asthma control including Asthma Control Test (ACT) score, classification of asthma control level[according to the Global Initiative for Asthma (GINA) 2015 classification system, as assessed by the physician completing the survey], perception of asthma (including question 1: nature of asthma as a disease; question 2: selection of first-line therapeutic agents to be regularly used daily for asthma; question 3: appropriate timing of the use of short-acting aerosols of β(2) receptor agonists; and question 4: therapeutic goals for asthma)...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28486439/branched-chain-and-aromatic-amino-acids-in-relation-to-behavioral-problems-among-young-inuit-from-nunavik-canada-a-cohort-study
#5
Audray St-Jean, Salma Meziou, Cynthia Roy, Pierre Ayotte, Gina Muckle, Michel Lucas
BackgroundObesity and insulin resistance are linked with mood disorders, and elevated concentrations of branched-chain (BCAAs) and aromatic amino acids (AAAs). Our study aimed to prospectively assess the relationship between childhood plasma BCAAs and AAAs, and behavioral problems in young Inuit from Nunavik.MethodsWe analyzed data on 181 children (with a mean age of 11.4 years at baseline) involved in the Nunavik Child Development Study. Plasma BCAA and AAA concentrations were measured in childhood (2005-2010)...
June 7, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28449006/a-meta-analysis-comparing-the-risk-of-metastases-in-patients-with-rectal-cancer-and-mri-detected-extramural-vascular-invasion-mremvi-vs-mremvi-negative-cases
#6
Muhammed R S Siddiqui, Constantinos Simillis, Chris Hunter, Manish Chand, Jemma Bhoday, Aurelie Garant, Te Vuong, Giovanni Artho, Shahnawaz Rasheed, Paris Tekkis, Al-Mutaz Abulafi, Gina Brown
BACKGROUND: Pathological extramural vascular invasion (EMVI) is an independent prognostic factor in rectal cancer, but can also be identified on MRI-detected extramural vascular invasion (mrEMVI). We perform a meta-analysis to determine the risk of metastatic disease at presentation and after surgery in mrEMVI-positive patients compared with negative tumours. METHODS: Electronic databases were searched from January 1980 to March 2016. Conventional meta-analytical techniques were used to provide a summative outcome...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28297074/cost-effectiveness-of-cervical-cancer-screening-methods-in-low-and-middle-income-countries-a-systematic-review
#7
REVIEW
Alex K Mezei, Heather L Armstrong, Heather N Pedersen, Nicole G Campos, Sheona M Mitchell, Musa Sekikubo, Josaphat K Byamugisha, Jane J Kim, Stirling Bryan, Gina S Ogilvie
The incidence of cervical cancer in low- and middle-income countries (LMICs) is five times higher than that observed in high-income countries (HICs). This discrepancy is largely attributed to the implementation of cytology-based screening programmes in HICs. However, due to reduced health system infrastructure requirements, HPV testing (self- and provider-collected) and visual inspection with acetic acid (VIA) have been proposed as alternatives that may be better suited to LMICs. Knowing the relative value of different screening options can inform policy and the development of sustainable prevention programs...
August 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28271431/state-of-the-art-conference-on-weight-management-in-va-policy-and-research-recommendations-for-advancing-behavioral-interventions
#8
Robin M Masheb, Stephanie H Chan, Susan D Raffa, Ronald Ackermann, Laura J Damschroder, Paul A Estabrooks, Gina Evans-Hudnall, Neil C Evans, Trina Histon, Alyson J Littman, Tannaz Moin, Karin M Nelson, Sherry Pagoto, Nico P Pronk, Deborah F Tate, Michael G Goldstein
This article summarizes outcomes of the behavioral interventions work group for the Veterans Health Administration (VHA) State of the Art Conference (SOTA) for Weight Management. Sixteen VHA and non-VHA subject matter experts, representing clinical care delivery, research, and policy arenas, participated. The work group reviewed current evidence of efficacy, effectiveness, and implementation of behavioral interventions for weight management, participated in phone- and online-based consensus processes, generated key questions to address gaps, and attended an in-person conference in March 2016...
April 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28263384/mesothelium-expression-of-vascular-cell-adhesion-molecule-1-vcam-1-is-associated-with-an-unfavorable-prognosis-in-epithelial-ovarian-cancer-eoc
#9
Jennifer M Scalici, Sanja Arapovic, Erin J Saks, Kristen A Atkins, Gina Petroni, Linda R Duska, Jill K Slack-Davis
BACKGROUND: Mesothelium vascular cell adhesion molecule-1 (VCAM-1) expression in the metastatic epithelial ovarian cancer (EOC) microenvironment is induced by tumor and mediates tumor cell invasion. VCAM-1 imaging suggests expression during treatment is an indicator of platinum resistance. Here, we assess the potential prognostic significance of mesothelium VCAM-1 expression and prospectively evaluate whether soluble VCAM-1 (sVCAM-1) is a surrogate for mesothelium expression. METHODS: A retrospective review of EOC patients was performed to evaluate outcomes with mesothelium VCAM-1 expression determined by immunohistochemistry of peritoneum or omentum specimens...
May 15, 2017: Cancer
https://www.readbyqxmd.com/read/28220751/upper-extremity-sarcoma-impact-of-current-practice-guidelines-and-controversies-on-reconstructive-approaches
#10
Marek Dobke, Gina A Mackert
The goals of sarcoma management include both a cure and the functional preservation of involved tissues and adjacent critical structures with common opinions favoring immediate reconstruction. The question arises whether these goals are contradictory. This paper discusses the question based on the experience of 28 patients with different types of extremity sarcoma, with 24 surgically treated by the University of California San Diego (UCSD) orthopedic and plastic surgery team (2011-2016) and the collection of evidence from published practice guidelines, reviews, case studies, and clinical trials...
2017: SICOT-J
https://www.readbyqxmd.com/read/28194650/healthy-aging-in-older-women-living-with-hiv-infection-a-systematic-review-of-psychosocial-factors
#11
REVIEW
Anna A Rubtsova, Mirjam-Colette Kempf, Tonya N Taylor, Deborah Konkle-Parker, Gina M Wingood, Marcia McDonnell Holstad
Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how OWLH live, cope, and age with HIV. Initial key word search yielded 1527 records, and 21 studies met our inclusion criteria of original quantitative or qualitative research published between 2013 and 2016 with results specific to OWLH...
February 13, 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/28167141/2016-updates-to-us-medical-eligibility-criteria-for-contraceptive-use-and-selected-practice-recommendations-for-contraceptive-use-%C3%A2-highlights-for-adolescent-patients
#12
REVIEW
Andrea J Hoopes, Katharine B Simmons, Emily M Godfrey, Gina S Sucato
The US Medical Eligibility Criteria for Contraceptive Use (MEC) and US Selected Practice Recommendations for Contraceptive Use (SPR) provide evidence-based guidance to safely provide contraception counseling and services. Both documents were updated in 2016 and are endorsed by the North American Society for Pediatric and Adolescent Gynecology. The purpose of this mini-review is to highlight updates to the US MEC and US SPR that are most relevant to health care providers of adolescents to support dissemination and implementation of these evidence-based best practices...
April 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28162984/eltrombopag-versus-placebo-for-low-risk-myelodysplastic-syndromes-with-thrombocytopenia-eqol-mds-phase-1-results-of-a-single-blind-randomised-controlled-phase-2-superiority-trial
#13
Esther N Oliva, Caterina Alati, Valeria Santini, Antonella Poloni, Alfredo Molteni, Pasquale Niscola, Flavia Salvi, Grazia Sanpaolo, Enrico Balleari, Ulrich Germing, Pierre Fenaux, Aspasia Stamatoullas, Giuseppe A Palumbo, Prassede Salutari, Stefana Impera, Paolo Avanzini, Agostino Cortelezzi, Anna Marina Liberati, Paola Carluccio, Francesco Buccisano, Maria Teresa Voso, Stefano Mancini, Austin Kulasekararaj, Fortunato Morabito, Monica Bocchia, Patrizia Cufari, Maria Antonietta Aloe Spiriti, Irene Santacaterina, Maria Grazia D'Errigo, Irene Bova, Gina Zini, Roberto Latagliata
BACKGROUND: In myelodysplastic syndromes, thrombocytopenia is associated with mortality, but treatments in this setting are scarce. We tested whether eltrombopag, a thrombopoietin receptor agonist, might be effective in improving thrombocytopenia in lower-risk myelodysplastic syndromes and severe thrombocytopenia. METHODS: EQoL-MDS was a single-blind, randomised, controlled, phase 2 superiority trial of adult patients with low-risk or International Prognostic Scoring System intermediate-1-risk myelodysplastic syndromes and severe thrombocytopenia...
March 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28149573/current-situation-of-asthma-copd-overlap-syndrome-acos-in-chinese-patients-older-than-40-years-with-airflow-limitation-rationale-and-design-for-a-multicenter-cross-sectional-trial-study-protocol
#14
Jian Kang, Wanzhen Yao, Baiqiang Cai, Ping Chen, Xia Ling, Hongyan Shang
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are the frequently occurring chronic airway diseases, and the overlapping syndrome observed in the majority of patients has been recently defined as asthma-COPD overlap syndrome (ACOS) by the Global Initiative for Chronic Obstructive Lung (GOLD, 2014) and Global initiative for Asthma (GINA, 2015). The proportion, features, and clinical practice of ACOS still remain elusive in China. We are conducting this multicenter, cross-sectional, observational study (NCT02600221) to investigate the distributions of chronic obstructive diseases in patients >40 years of age with chronic airflow limitation in China along with determination of the main clinical practice and features of these diseases...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28129261/identifying-augmented-renal-clearance-in-trauma-patients-validation-of-the-augmented-renal-clearance-in-trauma-intensive-care-scoring-system
#15
Jeffrey F Barletta, Alicia J Mangram, Marilyn Byrne, Joseph F Sucher, Alexzandra K Hollingworth, Francis R Ali-Osman, Gina R Shirah, Michael Haley, James K Dzandu
BACKGROUND: Augmented renal clearance (ARC) is common in trauma patients and associated with subtherapeutic antimicrobial concentrations. This study reported the incidence of ARC, identified ARC risk factors, and described a model to predict ARC (i.e., ARCTIC) that is specific to trauma patients. METHODS: Consecutive trauma patients who were admitted to the intensive care unit between March 2015 and January 2016 and had a measured creatinine clearance (CrCl) were considered for inclusion...
April 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28123859/epidemic-potential-for-local-transmission-of-zika-virus-in-2015-and-2016-in-queensland-australia
#16
Elvina Viennet, Gina Mincham, Francesca D Frentiu, Cassie C Jansen, Brian L Montgomery, David Harley, Robert L P Flower, Craig R Williams, Helen M Faddy
INTRODUCTION: Zika virus could be transmitted in the state of Queensland, Australia, in parts of the state where the mosquito vectors are established. METHODS: We assessed the epidemic potential of Zika in Queensland from January 2015 to August 2016, and estimate the epidemic potential from September to December 2016, by calculating the temperature-dependent relative vectorial capacity (rVc), based on empirical and estimated parameters. RESULTS: Through 2015, we estimated a rVc of 0...
December 13, 2016: PLoS Currents
https://www.readbyqxmd.com/read/28108191/use-of-electronic-cigarettes-among-u-s-adults-with-medical-comorbidities
#17
Gina R Kruse, Sara Kalkhoran, Nancy A Rigotti
INTRODUCTION: Electronic cigarette (e-cigarette) use is rising in the U.S. Smokers with comorbidities may increasingly use e-cigarettes if they believe e-cigarettes reduce smoking-related harm. This study examined e-cigarette use among adults with medical comorbidities. METHODS: In 2016, this study analyzed 68,136 U.S. adults in the 2014 and 2015 National Health Interview Survey. Prevalent e-cigarette use by medical comorbidities and adjusted odds of e-cigarette use were calculated...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28103615/radiation-induced-lung-metastasis-development-is-mt1-mmp-dependent-in-a-triple-negative-breast-cancer-mouse-model
#18
Gina Bouchard, Hélène Therriault, Sameh Geha, Rachel Bujold, Caroline Saucier, Benoit Paquette
BACKGROUND: The prognosis of triple-negative breast cancer (TNBC) is still difficult to establish. Some TNBC benefit from radiotherapy (RT) and are cured, while in other patients metastases appear during the first 3 years after treatment. In this study, an animal model of TNBC was used to determine whether the expression of the cell membrane protease MT1-MMP in cancer cells was associated with radiation-stimulated development of lung metastases. METHODS: Using invasion chambers, irradiated fibroblasts were used as chemoattractants to assess the invasiveness of TNBC D2A1 cell lines showing downregulated expression of MT1-MMP, which were compared with D2A1-wt (wild-type) and D2A1 shMT1-mock (empty vector) cell lines...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28097095/limited-knowledge-of-acetaminophen-in-patients-with-liver-disease
#19
Sammy Saab, Peter G Konyn, Matthew R Viramontes, Melissa A Jimenez, Jonathan F Grotts, Wally Hamidzadah, Veronica P Dang, Negin L Esmailzadeh, Gina Choi, Francisco A Durazo, Mohamed M El-Kabany, Steven-Huy B Han, Myron J Tong
Background and Aims: Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United States. Patients with underlying liver disease are at higher risk of poor outcomes from acetaminophen overdose. Limited knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver failure. The purpose of this study is to assess knowledge of acetaminophen dosing and presence of acetaminophen in common combination products in patients with liver disease...
December 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28093552/integrating-hebbian-and-homeostatic-plasticity-the-current-state-of-the-field-and-future-research-directions
#20
REVIEW
Tara Keck, Taro Toyoizumi, Lu Chen, Brent Doiron, Daniel E Feldman, Kevin Fox, Wulfram Gerstner, Philip G Haydon, Mark Hübener, Hey-Kyoung Lee, John E Lisman, Tobias Rose, Frank Sengpiel, David Stellwagen, Michael P Stryker, Gina G Turrigiano, Mark C van Rossum
We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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