keyword
https://read.qxmd.com/read/38525129/pathological-changes-in-various-organs-in-hla-b-57-01-transgenic-mice-with-abacavir-induced-skin-eruption
#21
JOURNAL ARTICLE
Akira Kazaoka, Kazuyoshi Kumagai, Junya Matsushita, Tetsuo Aida, Saki Kuwahara, Shigeki Aoki, Kousei Ito
UNLABELLED: Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a few patients resulting in death due to multiorgan failure. Understanding the sequential changes in various organs in patients with cutaneous eruption following drug administration will help understand disease onset and progression, aiding the development of prevention strategies and interventions. Therefore, we aimed to understand the effects of abacavir (ABC) on various organs in patients with ABC-induced eruptions by evaluating its effects in a mouse model...
April 2024: Toxicological Research
https://read.qxmd.com/read/38525053/maternal-near-miss-hospitalizations-in-the-borana-zone-ethiopia-a-facility-based-longitudinal-cross-sectional-study
#22
JOURNAL ARTICLE
Boboh Kamangira, Gudeta Ayele, Polite Dube, Kaleb Melaku, Eubert Vushoma
BACKGROUND: Maternal near miss refers to a woman who nearly died but survived a complication that occurred during pregnancy, childbirth, or within 42 days of pregnancy termination. While there has been considerable progress in reducing maternal mortality rates, maternal near miss cases can provide valuable insights into the quality of maternal healthcare and help identify areas for improvement. However, there is limited evidence on the factors contributing to maternal near miss cases, including health system failures, delays in care, and provider-related factors...
January 2024: Journal of Public Health Research
https://read.qxmd.com/read/38524804/a-drug-prescription-recommendation-system-based-on-novel-diakid-ontology-and-extensive-semantic-rules
#23
JOURNAL ARTICLE
Kadime Göğebakan, Ramazan Ulu, Rahib Abiyev, Melike Şah
According to the World Health Organization (WHO) data from 2000 to 2019, the number of people living with Diabetes Mellitus and Chronic Kidney Disease (CKD) is increasing rapidly. It is observed that Diabetes Mellitus increased by 70% and ranked in the top 10 among all causes of death, while the rate of those who died from CKD increased by 63% and rose from the 13th place to the 10th place. In this work, we combined the drug dose prediction model, drug-drug interaction warnings and drugs that potassium raising (K-raising) warnings to create a novel and effective ontology-based assistive prescription recommendation system for patients having both Type-2 Diabetes Mellitus (T2DM) and CKD...
December 2024: Health Information Science and Systems
https://read.qxmd.com/read/38524525/extended-survival-with-metastatic-pancreatic-cancer-under-fruquintinib-treatment-after-failed-chemotherapy-two-case-reports
#24
Dan Wu, Qiong Wang, Shuai Yan, Xia Sun, Ya Qin, Ming Yuan, Nan-Yao Wang, Xian-Ting Huang
BACKGROUND: Pancreatic cancer is a highly malignant disease. After decades of treatment progress, the current five-year survival rate for patients is still less than 10%. For later-line treatment, the treatment options are even more limited. Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer. Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis, improving the abnormal vascular structure, and modulating the tumour immune microenvironment...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38524226/characteristics-and-outcomes-of-pregnant-women-hospitalized-with-laboratory-confirmed-respiratory-syncytial-virus-before-and-during-the-covid-19-pandemic
#25
JOURNAL ARTICLE
Jennifer Milucky, Kadam Patel, Monica E Patton, Pam Daily Kirley, Elizabeth Austin, James Meek, Evan J Anderson, Alicia Brooks, Chloe Brown, Erica Mumm, Yadira Salazar-Sanchez, Grant Barney, Kevin Popham, Melissa Sutton, H Keipp Talbot, Melanie T Crossland, Fiona P Havers
BACKGROUND: Respiratory syncytial virus (RSV) can cause severe disease among infants and older adults. Less is known about RSV among pregnant women. METHODS: To analyze hospitalizations with laboratory-confirmed RSV among women aged 18 to 49 years, we used data from the RSV Hospitalization Surveillance Network (RSV-NET), a multistate population-based surveillance system. Specifically, we compared characteristics and outcomes among (1) pregnant and nonpregnant women during the pre-COVID-19 pandemic period (2014-2018), (2) pregnant women with respiratory symptoms during the prepandemic and pandemic periods (2021-2023), and (3) pregnant women with and without respiratory symptoms in the pandemic period...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38524110/acute-methotrexate-toxicity-in-a-patient-with-psoriasis-a-case-report
#26
Hind Abouzahir, Ahmed Belhouss, Hicham Benyaich
Aside from rheumatoid arthritis, methotrexate is also used to treat cancer, psoriasis, and other diseases. Side effects with methotrexate are possible, as they are with any medication. This drug is extremely potent and has the potential to produce serious adverse effects. Those who use this medication need to be tracked often. We provide a case of a patient with psoriasis vulgaris who died due to methotrexate administration without proper dosage verification. A female patient in her forties had a history of psoriasis vulgaris of the lower limbs...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38524105/neonatal-mortalities-without-detected-risk-factors-before-birth-at-mtendeli-hospital-tanzania-a-cross-sectional-study
#27
JOURNAL ARTICLE
Alen Kinyina, Sarah Mohamed Chamos, Hussein Moremi, Melkior Assenga, Mussa Bago, Renatus Mathias
INTRODUCTION: neonatal mortality rate (NMR) is defined as the probability of dying during the first 28 days of life expressed per 1,000 live births. The death of neonates without risk factors at the end of pregnancy could be an indicator of sub-optimal quality care during labor and care of sick neonates. Therefore, this study aimed to determine the factors associated with neonatal deaths happening without detected risks during prenatal period. METHODS: a cross-sectional study was conducted from 2017 to 2021...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38524091/retrospective-observational-study-to-assess-safety-and-tolerability-of-nebulized-colistin-for-the-treatment-of-patients-with-pneumonia-in-real-world-settings-in-respiratory-icu
#28
JOURNAL ARTICLE
Deepak Talwar, Deepak Prajapat, Surbhi Talwar, Dhruv Talwar
INTRODUCTION: Colistin is used to treat hospital-acquired pneumonia and ventilator-associated pneumonia. However, direct drug deposition at the site of infection may improve its efficacy and reduce systemic exposure. The aim of this study was to assess the safety and tolerability of nebulized colistin among Indian patients diagnosed with pneumonia caused by multidrug-resistant gram-negative bacilli in real-world settings. METHODOLOGY: We retrospectively reviewed the medical records of patients treated with nebulized colistin for pneumonia...
February 2024: Curēus
https://read.qxmd.com/read/38523960/variation-in-access-to-palliative-radiotherapy-in-prostate-cancer-a-population-based-study-in-canada
#29
JOURNAL ARTICLE
Alborz Jooya, Daniel Qureshi, William J Phillips, Jennifer Leigh, Colleen Webber, Ajay Aggarwal, Peter Tanuseputro, Scott Morgan, Robert Macrae, Michael Ong, Jean-Marc Bourque
BACKGROUND: As a result of improvements in cancer therapies, patients with metastatic malignancies are living longer, and the role of palliative radiotherapy has become increasingly recognized. However, access to adequate palliative radiotherapy may continue to be a challenge, as is evident from the high proportion of patients dying of prostate cancer who never receive palliative radiotherapy. The main objective of this investigation is to identify and describe the factors associated with the receipt of palliative radiation treatment in a decedent cohort of prostate cancer patients in Ontario...
February 2024: Curēus
https://read.qxmd.com/read/38523945/histological-changes-in-adrenal-glands-in-suicidal-and-sudden-death-cases-a-postmortem-study
#30
JOURNAL ARTICLE
Sangita Chaurasia, Anshuli Trivedi, Ruchi Ganvir, Saagar Singh, Jayanthi Yadav, Reeni Malik, Sneha Choubal, Arneet Arora
Introduction Various studies have linked suicidal behavior, stress, affective disorders, and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis resulting from chronic stress. Chronic stress has been shown to cause enlargement of the adrenal glands, altering their function and potentially leading to suicidal behaviors in individuals with depression. This study aimed to compare the histological changes in the adrenal glands of individuals who died by suicide with those who experienced sudden death...
February 2024: Curēus
https://read.qxmd.com/read/38523856/encephalopathy-after-a-high-dose-dexamethasone-suppression-test-in-a-woman-with-x-linked-ornithine-transcarbamylase-deficiency
#31
Hyunho Seol, Yoon Hee Hong, Min Ji Jeon
BACKGROUND/OBJECTIVE: The high-dose dexamethasone suppression test is a common and usually benign endocrine procedure. We report a patient with ornithine transcarbamylase deficiency (OTCD) who developed hyperammonemic encephalopathy after a high-dose dexamethasone suppression test. CASE REPORT: A 46-year-old woman with a 1.3-cm right adrenal incidentaloma causing mild autonomous cortisol secretion underwent a high-dose dexamethasone suppression test for confirming adrenocorticotropic hormone independency...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38523312/physical-activity-is-associated-with-a-lower-risk-of-contracting-and-dying-in-infection-and-sepsis-a-swedish-population-based-cohort-study
#32
JOURNAL ARTICLE
Karl Stattin, Mikael Eriksson, Robert Frithiof, Rafael Kawati, Michael Hultström, Miklos Lipcsey
BACKGROUND: Sepsis is a condition where the immune response to infection becomes dysregulated and life-threatening. It is not known whether lifestyle factors influence the risk of sepsis. The aim of the present study is to investigate the association between physical activity and the risk of acquiring and dying in infection or sepsis. METHODS: The population-based Swedish Mammography Cohort and Cohort of Swedish Men sent participants lifestyle questionnaires in 1997 and have subsequently followed participants in national Swedish registers, including the National Patient Register, the Swedish Intensive Care Registry and the Cause of Death Register...
March 24, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38523257/adult-offspring-s-education-and-parental-mortality-a-nationwide-cohort-study-of-the-mediating-role-of-lifestyle-related-diseases
#33
JOURNAL ARTICLE
Mathilde M B Sloth, Emma Neble Larsen, Jimmi Mathisen, Charlotte J Nilsson, Merete Osler, Terese S H Jørgensen
Aim: The mechanisms behind the association between adult offspring's socioeconomic position and their parents' mortality are not well understood. This study investigates lifestyle-related diseases as a potential mediating pathway between adult offspring's education and parental mortality. Methods: This nationwide register-based cohort study consists of 963,742 older adults aged 65 years between 2000 and 2018. Lifestyle-related diseases were measured between 60 and 65 years and those with prior lifestyle-related diseases were excluded...
March 24, 2024: Scandinavian Journal of Public Health
https://read.qxmd.com/read/38522521/disruption-of-polyunsaturated-fatty-acid-biosynthesis-drives-sting-dependent-acute-myeloid-leukemia-cell-maturation-and-death
#34
JOURNAL ARTICLE
Joice Kanefsky, Mary Basse, Judith Sokei, Orsola di Martino, Liana Valin, Yorrick Jaspers, Esteban Martinez, Jacklyn Huhn, Daniela Di Marcantonio, Jeffrey A Magee, Aaron R Goldman, Hsin-Yao Tang, Francesca Ferraro, Stephan Kemp, David L Wiest, Stephen M Sykes
The role of polyunsaturated fatty acid (PUFA) biosynthesis in acute myeloid leukemia (AML) remains largely undefined. A comparative expression analysis of 35 genes encoding fatty acid biosynthesis enzymes showed that Fatty Acid Desaturase 1 (FADS1) was highly expressed across multiple AML subtypes relative to health controls, and that elevated FADS1 expression correlates with worse overall AML patient survival. Functionally, shRNA-mediated inhibition of FADS1 reduced AML cell growth in vitro and significantly delayed leukemia onset in an AML mouse model...
March 22, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38522443/effectiveness-of-bubble-continuous-positive-airway-pressure-for-treatment-of-children-aged-1-59-months-with-severe-pneumonia-and-hypoxaemia-in-ethiopia-a-pragmatic-cluster-randomised-controlled-trial
#35
JOURNAL ARTICLE
Meseret Gebre, Kassa Haile, Trevor Duke, Md Tanveer Faruk, Mehnaz Kamal, Md Farhad Kabir, Md Fakhar Uddin, Muluye Shimelis, Tigist Beyene, Bethelhem Solomon, Meles Solomon, Abebe Genetu Bayih, Alemseged Abdissa, Taye Tolera Balcha, Rahel Argaw, Asrat Demtse, Abate Yeshidinber Weldetsadik, Abayneh Girma, Bitseat W Haile, Abu Sadat Mohammad Sayeem Bin Shahid, Tahmeed Ahmed, John D Clemens, Mohammod Jobayer Chisti
BACKGROUND: The safety and efficacy of bubble continuous positive airway pressure (bCPAP) for treatment of childhood severe pneumonia outside tertiary care hospitals is uncertain. We did a cluster-randomised effectiveness trial of locally made bCPAP compared with WHO-recommended low-flow oxygen therapy in children with severe pneumonia and hypoxaemia in general hospitals in Ethiopia. METHODS: This open, cluster-randomised trial was done in 12 general (secondary) hospitals in Ethiopia...
March 21, 2024: Lancet Global Health
https://read.qxmd.com/read/38522361/endobronchial-silicone-spigot-in-prolonged-air-leaks-nationwide-study-on-outcomes-and-risk-factors-for-treatment-failure
#36
JOURNAL ARTICLE
Jumpei Taniguchi, Shotaro Aso, Jo Taisuke, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: The endobronchial silicone spigot, also known as the endobronchial Watanabe spigot, is used in bronchoscopic interventions to manage prolonged pulmonary air leakage. However, the outcomes of this procedure have not been thoroughly investigated. METHODS: Using a Japanese national inpatient database from April 2014 to March 2022, we assessed the clinical characteristics and outcomes of all eligible patients who received the endobronchial spigot. We also investigated risk factors associated with treatment failure...
March 23, 2024: Respiratory Investigation
https://read.qxmd.com/read/38521839/tuberculosis-case-fatality-is-higher-in-male-than-female-patients-in-europe-a-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
Stephanie Pape, Sudip Jung Karki, Torben Heinsohn, Iris Brandes, Marie-Luise Dierks, Berit Lange
PURPOSE: Epidemiological TB data indicate differences in infection prevalence, progression rates, and clinical disease incidence between sexes. In contrast, evidence on sex-specific differential (post) TB case fatality in Europe has not been synthesized systematically. METHODS: We searched electronic databases and grey literature up to December 2020 for studies reporting sex-stratified TB death data for Europe. The JBI critical appraisal tools served for bias risk assessment and subgroup analyses for studying heterogeneity...
March 23, 2024: Infection
https://read.qxmd.com/read/38520525/fresh-fruit-dried-fruit-raw-vegetables-and-cooked-vegetables-consumption-associated-with-progression-trajectory-of-type-2-diabetes-a-multi-state-analysis-of-a-prospective-cohort
#38
JOURNAL ARTICLE
Guzhengyue Zheng, Shanshan Ran, Jingyi Zhang, Aaron M Qian, Junjie Hua, Chongjian Wang, Michael G Vaughn, Maya Tabet, Hualiang Lin
PURPOSE: To examine the effects of fresh fruit, dried fruit, raw vegetables, and cooked vegetables on type 2 diabetes (T2D) progression trajectory. METHODS: We included 429,886 participants in the UK Biobank who were free of diabetes and diabetes complications at baseline. Food groups were determined using a validated food frequency questionnaire. Outcomes were T2D incidence, complications, and mortality. Multi-state model was used to analyze the effects of food groups on T2D progression...
March 23, 2024: European Journal of Nutrition
https://read.qxmd.com/read/38520430/identifying-subgroups-of-youth-suicide-decedents-based-on-clinical-profiles-of-psychiatric-and-medical-diagnoses-a-latent-class-analysis
#39
JOURNAL ARTICLE
Amanda J Thompson, Christopher C Henrich, Danielle L Steelesmith, Jennifer Hughes, Donna Ruch, Jeffrey A Bridge, John V Campo, Cynthia A Fontanella
PURPOSE: To identify risk subgroups of youth suicide decedents using demographic and clinical psychiatric and medical diagnostic profiles to inform tailored youth suicide prevention efforts. METHODS: This study linked Ohio Medicaid and death certificate data for Medicaid enrolled youth aged 8-25 years who died by suicide between January 1, 2010, and December 31, 2020 (N = 511). Latent class analysis was used to identify distinct clinical risk subgroups. RESULTS: Three latent classes were identified...
March 21, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38519890/serum-cholesterol-level-as-a-predictive-biomarker-for-prognosis-of-neuroblastoma
#40
JOURNAL ARTICLE
Jie Min, Yi Wu, Shungen Huang, Yanhong Li, Xinjing Lv, Ruze Tang, He Zhao, Jian Wang
BACKGROUND: Neuroblastoma (NB), a type of solid tumor in children, has a poor prognosis. Few blood biomarkers can accurately predict the prognosis, including recurrence and survival, in children with NB. In this study, we found that the serum total cholesterol (Tchol) level was associated with the prognosis of patients through a retrospective study. METHODS: Multivariate Cox regression model was used to identify the independent risk factors in the children with NB...
March 22, 2024: BMC Pediatrics
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