Yue Yang, Yuhan Cheng, Tao Bai, Shimeng Liu, Qiuhui Du, Wenhao Xia, Yi Liu, Xiao Wang, Xianqing Chen
Trilobatin (TBL) is a key sweet compound from the traditional Chinese sweet tea plant ( Rubus suavissimus S. Lee ). Because of its intense sweetness, superior taste profile, and minimal caloric value, it serves as an exemplary natural dihydrochalcone sweetener. It also has various health benefits, including anti-inflammatory and glucose-lowering effects. It is primarily produced through botanical extraction, which impedes its scalability and cost-effectiveness. In a novel biotechnological approach, phloretin is used as a precursor that is transformed into TBL by the glycosyltransferase enzyme ph-4'-OGT...
January 30, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry