Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan
INTRODUCTION: Advanced maternal age is associated with reduced implantation and pregnancy rates, yet the underlying mechanisms remain poorly understood, and research models are limited. OBJECTIVES: Here, we aim to elucidate the impacts of senescence on implantation ability by employing blastoids to construct a novel research model. METHODS: We used a novel three-dimensional system with totipotent blastomere-like cells (TBLCs) to construct TBL-blastoids and established senescence-related embryo models derived from oxidative stress-induced TBLCs...
February 23, 2024: Journal of Advanced Research