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liver 3D reconstruction

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https://www.readbyqxmd.com/read/29568983/model-prediction-and-validation-of-an-order-mechanism-controlling-the-spatiotemporal-phenotype-of-early-hepatocellular-carcinoma
#1
Stefan Hoehme, Francois Bertaux, William Weens, Bettina Grasl-Kraupp, Jan G Hengstler, Dirk Drasdo
Recently, hepatocyte-sinusoid alignment (HSA) has been identified as a mechanism that supports the coordination of hepatocytes during liver regeneration to reestablish a functional micro-architecture (Hoehme et al. in Proc Natl Acad Sci 107(23):10371-10376, 2010). HSA means that hepatocytes preferentially align along the closest micro-vessels. Here, we studied whether this mechanism is still active in early hepatocellular tumors. The same agent-based spatiotemporal model that previously correctly predicted HSA in liver regeneration was further developed to simulate scenarios in early tumor development, when individual initiated hepatocytes gain increased proliferation capacity...
March 22, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29567047/augmented-reality-technology-for-preoperative-planning-and-intraoperative-navigation-during-hepatobiliary-surgery-a-review-of-current-methods
#2
Rui Tang, Long-Fei Ma, Zhi-Xia Rong, Mo-Dan Li, Jian-Ping Zeng, Xue-Dong Wang, Hong-En Liao, Jia-Hong Dong
BACKGROUND: Augmented reality (AR) technology is used to reconstruct three-dimensional (3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes. DATA SOURCES: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the PubMed database...
February 19, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29502942/development-of-a-perfusable-3d-liver-cell-cultivation-system-via-bundling-up-assembly-of-cell-laden-microfibers
#3
Yuya Yajima, Chu Ning Lee, Masumi Yamada, Rie Utoh, Minoru Seki
Although the reconstruction of functional 3D liver tissue models in vitro presents numerous challenges, it is in great demand for drug development, regenerative medicine, and physiological studies. Here we propose a new approach to perform perfusion cultivation of liver cells by assembling cell-laden hydrogel microfibers. HepG2 cells were densely packed into the core of sandwich-type anisotropic microfibers, which were produced using microfluidic devices. The obtained microfibers were bundled up and packed into a perfusion chamber, and perfusion cultivation was performed...
March 1, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29430662/on-the-feasibility-of-automatically-selecting-similar-patients-in-highly-individualized-radiotherapy-dose-reconstruction-for-historic-data-of-pediatric-cancer-survivors
#4
Marco Virgolin, Irma W E M van Dij, Jan Wiersma, Cécile M Ronckers, Cees Witteveen, Arjan Bel, Tanja Alderliesten, Peter A N Bosman
PURPOSE: The aim of this study is to establish the first step towards a novel and highly individualized 3D dose distribution reconstruction method, based on CT scans and organ delineations of recently treated patients. Specifically, the feasibility of automatically selecting the CT scan of a recently treated childhood cancer patient who is similar to a given historically treated child who suffered from Wilms' tumor is assessed. METHODS: A cohort of 37 recently treated children between 2 and 6 years old is considered...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29386002/extended-left-hepatectomy-for-intrahepatic-cholangiocarcinoma-hepatic-vein-reconstruction-with-in-situ-hypothermic-perfusion-and-extracorporeal-membrane-oxygenation
#5
Deniz Balci, Menekse Ozcelik, Elvan Onur Kirimker, Arda Cetinkaya, Evren Ustuner, Mehmet Cakici, Bahadir Inan, Zekeriyya Alanoglu, Sadik Bilgic, Ahmet Ruchan Akar
BACKGROUND: Liver resection for intrahepatic cholangiocarcinoma (ICC) with invasion of the inferior vena cava (IVC) and hepatic veins (HV) is a challenging procedure. CASE PRESENTATION: We report a case of a 63-year-old woman with a 6-cm, centrally located liver mass. Her biochemistry results were normal except for a Ca19-9 level of 1199 U/ml. The liver biopsy was consistent with ICC and 60% macrosteatosis. Abdominal CT scans revealed a large central mass invading the left HV, middle HV and right HV, infringing on their junction with the vena cava...
January 31, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29383733/impact-of-missing-attenuation-and-scatter-corrections-on-99m-tc-maa-spect-3d-dosimetry-for-liver-radioembolization-using-the-patient-relative-calibration-methodology-a-retrospective-investigation-on-clinical-images
#6
Francesca Botta, Mahila Ferrari, Carlo Chiesa, Sara Vitali, Francesco Guerriero, Maria Chiara De Nile, Marta Mira, Leda Lorenzon, Massimiliano Pacilio, Marta Cremonesi
PURPOSE: To investigate the clinical implication of performing pre-treatment dosimetry for 90 Y-microspheres liver radioembolization on 99m Tc-MAA SPECT images reconstructed without attenuation or scatter correction and quantified with the patient relative calibration methodology. METHODS: 25 patients treated with SIR-Spheres® at Istituto Europeo di Oncologia and 31 patients treated with TheraSphere® at Istituto Nazionale Tumori were considered. For each acquired 99m Tc-MAA SPECT, four reconstructions were performed: with attenuation and scatter correction (AC_SC), only attenuation (AC_NoSC), only scatter (NoAC_SC) and without corrections (NoAC_NoSC)...
January 31, 2018: Medical Physics
https://www.readbyqxmd.com/read/29372469/single-breath-hold-abdominal-formula-see-text-mapping-using-3d-cartesian-look-locker-with-spatiotemporal-sparsity-constraints
#7
Felix Lugauer, Jens Wetzl, Christoph Forman, Manuel Schneider, Berthold Kiefer, Joachim Hornegger, Dominik Nickel, Andreas Maier
OBJECTIVE: Our aim was to develop and validate a 3D Cartesian Look-Locker [Formula: see text] mapping technique that achieves high accuracy and whole-liver coverage within a single breath-hold. MATERIALS AND METHODS: The proposed method combines sparse Cartesian sampling based on a spatiotemporally incoherent Poisson pattern and k-space segmentation, dedicated for high-temporal-resolution imaging. This combination allows capturing tissue with short relaxation times with volumetric coverage...
January 25, 2018: Magma
https://www.readbyqxmd.com/read/29356993/phantom-and-clinical-evaluation-of-the-effect-of-full-monte-carlo-collimator-modelling-in-post-sirt-yttrium-90-bremsstrahlung-spect-imaging
#8
Charlotte A Porter, Kevin M Bradley, Eero T Hippeläinen, Matthew D Walker, Daniel R McGowan
BACKGROUND: Post-therapy SPECT/CT imaging of 90 Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by 90 Y. This study aimed to evaluate the utility of a commercially available software package (HybridRecon, Hermes Medical Solutions AB) which incorporates full Monte Carlo collimator modelling. Analysis of image quality was performed on both phantom and clinical images in order to ultimately provide a recommendation of an optimum reconstruction for post-therapy 90 Y microsphere SPECT/CT imaging...
January 22, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29325356/-the-role-and-significance-of-digital-reconstruction-technique-in-liver-segments-based-on-portal-vein-structure
#9
X J Zhou, Q Dong, C Z Zhu, X Chen, B Wei, Y H Duan, J Zhao, X W Hao, H Zhang, P Nie, B Hu, W J Xu, R W Shen, Z H Chen, K R Dong, Y Z Bai, Q Shu, W J Luo, F Gao, N Xia, Q Y Yu
Objective: To study the segment of liver according to the large amount of three-dimensional(3D) reconstructive images of normal human livers and the vascular system, and to recognize the basic functional liver unit based on the anatomic features of the intrahepatic portal veins. Methods: The enhanced CT primitive DICOM files of 1 260 normal human livers from different age groups who treated from October 2013 to February 2017 provided by 16 hospitals were analyzed using the computer-aided surgery system.The 3D liver and liver vascular system were reconstructed, and the digital liver 3D model was established...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29261334/respiratory-motion-correction-for-free-breathing-3d-abdominal-mri-using-cnn-based-image-registration-a-feasibility-study
#10
Jun Lv, Ming Yang, Jue Zhang, Xiaoying Wang
OBJECTIVE: Free-breathing abdomen imaging requires non-rigid motion registration of unavoidable respiratory motion in three-dimensional undersampled data sets. In this work, we introduce an image registration method based on the convolutional neural network (CNN) to obtain motion-free abdominal images throughout the respiratory cycle. METHODS: Abdominal data were acquired from 10 volunteers using a 1.5 T MRI system. The respiratory signal was extracted from the central-space spokes, and the acquired data were reordered in three bins according to the corresponding breathing signal...
February 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29224266/-application-of-liver-three-dimensional-visualization-technologies-in-the-treatment-planning-of-hepatic-malignant-tumor
#11
P P Li, Z H Wang, G Huang, Z P Huang, Y Li, J S Ni, H Liu, C H Fang, W P Zhou
Objective: To discuss the application of three dimentional(3D)visualization technologies in treatment plan of hepatic malignant tumor. Methods: The clinical data of 300 patients with liver malignant tumor who received treatment from January 2016 to January 2017 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital was retrospectively analyzed in this study, including 221 male and 79 female patients aged from 7 to 76 years with median age of 54 years. The median height was 168 cm (115-183 cm), the median weight was 65 kg (20-105 kg) and the median tumor volume was 142 ml (23-2 493 ml)...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29214994/human-liver-segments-role-of-cryptic-liver-lobes-and-vascular-physiology-in-the-development-of-liver-veins-and-left-right-asymmetry
#12
Jill P J M Hikspoors, Mathijs M J P Peeters, Nutmethee Kruepunga, Hayelom K Mekonen, Greet M C Mommen, S Eleonore Köhler, Wouter H Lamers
Couinaud based his well-known subdivision of the liver into (surgical) segments on the branching order of portal veins and the location of hepatic veins. However, both segment boundaries and number remain controversial due to an incomplete understanding of the role of liver lobes and vascular physiology on hepatic venous development. Human embryonic livers (5-10 weeks of development) were visualized with Amira 3D-reconstruction and Cinema 4D-remodeling software. Starting at 5 weeks, the portal and umbilical veins sprouted portal-vein branches that, at 6...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208767/the-feasibility-of-low-concentration-contrast-and-low-tube-voltage-in-computed-tomography-perfusion-imaging-an-animal-study
#13
Yuning Pan, Aiqin Song, Shizhong Bu, Zhaoqian Chen, Qiuli Huang, Aijing Li
Aim : To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging.Method : A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan...
February 28, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29205328/quantitative-analysis-of-hepatic-macro-and-microvascular-alterations-during-cirrhogenesis-in-the-rat
#14
Geert Peeters, Charlotte Debbaut, Adrian Friebel, Pieter Cornillie, Winnok H De Vos, Kasper Favere, Ingrid Vander Elst, Tim Vandecasteele, Tim Johann, Luc Van Hoorebeke, Diethard Monbaliu, Dirk Drasdo, Stefan Hoehme, Wim Laleman, Patrick Segers
Cirrhosis represents the end-stage of any persistent chronically active liver disease. It is characterized by the complete replacement of normal liver tissue by fibrosis, regenerative nodules, and complete fibrotic vascularized septa. The resulting angioarchitectural distortion contributes to an increasing intrahepatic vascular resistance, impeding liver perfusion and leading to portal hypertension. To date, knowledge on the dynamically evolving pathological changes of the hepatic vasculature during cirrhogenesis remains limited...
March 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29198945/quantitative-measurements-versus-receiver-operating-characteristics-and-visual-grading-regression-in-ct-images-reconstructed-with-iterative-reconstruction-a-phantom-study
#15
Kristin Jensen, Hilde Kjernlie Andersen, Örjan Smedby, Bjørn Helge Østerås, Anette Aarsnes, Anders Tingberg, Erik Fosse, Anne Catrine Martinsen
RATIONALE AND OBJECTIVES: This study aimed to evaluate the correlation of quantitative measurements with visual grading regression (VGR) and receiver operating characteristics (ROC) analysis in computed tomography (CT) images reconstructed with iterative reconstruction. MATERIALS AND METHODS: CT scans on a liver phantom were performed on CT scanners from GE, Philips, and Toshiba at three dose levels. Images were reconstructed with filtered back projection (FBP) and hybrid iterative techniques (ASiR, iDose, and AIDR 3D of different strengths)...
November 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29140117/comparison-of-radiation-dose-and-image-quality-of-abdominopelvic-ct-using-iterative-aidr-3d-and-conventional-reconstructions
#16
Caroline Duarte de Mello-Amoedo, Aparecido Nakano Martins, Adriano Tachibana, Daniella Ferraro Pinho, Ronaldo Hueb Baroni
OBJECTIVE: The purpose of this study is to compare radiation dose and image quality of abdominopelvic CT studies reconstructed with iterative and conventional techniques. MATERIALS AND METHODS: This retrospective study enrolled 99 patients who underwent abdominopelvic CT examinations with the portal venous phase images reconstructed with both filtered back projection and Adaptive Iterative Dose Reduction 3D (AIDR 3D) at different time points. Subjective assessment of image quality was performed by two radiologists who scored axial images for overall quality, sharpness, noise, and acceptability in a blinded fashion...
January 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29128598/histological-and-radiological-evaluation-of-subcutaneous-implants-in-mouse-of-a-3d-printable-material-fulcure-720-and-experimental-application-in-mandibular-reconstruction
#17
J Megías Barrera, L García-Consuegra, A Novoa, S Costilla, S Junquera, G Ascani
INTRODUCTION: The aim of this study was to evaluate the bioactivity of Fullcure compared to porous polyethylene implants (Medpor) in rats prior to custom-made scaffold support manufacturing for mandible segmental defects (MSD) reconstruction in sheep. METHODS: Twelve Fullcure and Medpor laminaes were implanted in the left and right dorsum respectively of six wistar rats. Toxicity was assessed by skin, kidney and liver histopathology three months post-implantation...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29116221/establishment-of-a-fluorescent-in-situ-hybridization-assay-for-imaging-hepatitis-b-virus-nucleic-acids-in-cell-culture-models
#18
Xiaonan Zhang, Lei Yue, Zhanqing Zhang, Zhenghong Yuan
While chronic hepatitis B remains a global public health problem, the detailed spatiotemporal dynamics of the key molecular events leading to the multiplication and egress of hepatitis B virus (HBV) are still largely unclear. Previously, we developed a chromogenic in situ hybridization assay for detection of HBV RNA, DNA and covalently closed circular DNA in clinical liver biopsies. Here, we report the establishment of a fluorescent in situ hybridization method for the visualization of HBV RNA, HBV core particle DNA and intranuclear DNA in a tetracycline-inducible HBV replication system (HepAD38) and a de novo infection system (HepG2-NTCP)...
November 8, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29103469/improved-clinical-workflow-for-simultaneous-whole-body-pet-mri-using-high-resolution-caipirinha-accelerated-mr-based-attenuation-correction
#19
Martin T Freitag, Matthias Fenchel, Philipp Bäumer, Thorsten Heußer, Christopher M Rank, Marc Kachelrieß, Daniel Paech, Klaus Kopka, Sebastian Bickelhaupt, Antonia Dimitrakopoulou-Strauss, Klaus Maier-Hein, Ralf Floca, Mark E Ladd, Heinz-Peter Schlemmer, Florian Maier
PURPOSE: To explore the value and reproducibility of a novel magnetic resonance based attenuation correction (MRAC) using a CAIPIRINHA-accelerated T1-weighted Dixon 3D-VIBE sequence for whole-body PET/MRI compared to the clinical standard. METHODS: The PET raw data of 19 patients from clinical routine were reconstructed with standard MRAC (MRACstd) and the novel MRAC (MRACcaipi), a prototype CAIPIRINHA accelerated Dixon 3D-VIBE sequence, both acquired in 19 s/bed position...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29084421/hepatogenic-differentiation-capacity-of-human-wharton-s-jelly-mesenchymal-stem-cell-in-a-co-culturing-system-with-endothelial-cells-in-matrigel-collagen-scaffold-in-the-presence-of-fetal-liver-extract
#20
Zahra Khodabandeh, Zahra Vojdani, Tahereh Talaei-Khozani, Soghra Bahmanpour
Background: Human Wharton's jelly mesenchymal stem cells (HWJMSCs) isolated from medical waste product can be considered as an accessible source of cells in regenerative medicine. Stem cell-derived hepatocytes have poor function and need appropriate niche to reconstruct the liver structure. Therefore, we attempted to find a novel approach in differentiating HWJMSCs into functional hepatic cells using 3D culture conditions and liver extract that recapitulates vital stage in liver development...
November 30, 2017: International Journal of Stem Cells
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