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https://www.readbyqxmd.com/read/29475140/the-prognostic-relevance-of-sentinel-lymph-node-metastases-assessed-by-phgr1-mrna-quantification-in-stage-i-to-iii-colon-cancer
#1
Satu Oltedal, Hartwig Kørner, Ole Gunnar Aasprong, Israr Hussain, Kjersti Tjensvoll, Rune Smaaland, Jon Arne Søreide, Kjetil Søreide, Ragnhild A Lothe, Reino Heikkilä, Bjørnar Gilje, Oddmund Nordgård
BACKGROUND: Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph node (SLN) metastases in colon cancer patients by measuring the novel metastasis marker PHGR1 mRNA. METHODS: Using quantitative reverse-transcription polymerase chain reaction, we measured PHGR1 mRNA levels in SLNs and primary tumors from 206 patients surgically treated for stage I to III colon cancer and 52 normal LNs from patients undergoing surgery for benign colon diseases...
February 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29474884/cardiopulmonary-exercise-testing-in-hepato-biliary-pancreas-cancer-surgery-a-systematic-review-are-we-any-further-than-walking-up-a-flight-of-stairs
#2
REVIEW
R Kumar, G Garcea
INTRODUCTION: Cardiopulmonary exercise testing (CPET) is a reliable, reproducible and non-invasive measure of functional capacity. CPET has been increasingly used to assess pre-operative risk and stratify patients at risk of mortality and morbidity following surgery. CPET parameters that predict outcomes within liver and pancreas cancer surgery still remain to be defined. METHODS: A systematic review to assess CPET use in predicting post-operative outcomes in liver and pancreas cancer surgery was carried out using the following databases AMED, CINAHL, Cochrane Library, EMBASE, Google Scholar and PubMED...
February 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29474646/serum-levels-of-testosterone-and-shbg-in-association-with-body-mass-index-improve-the-predictive-capability-of-consolidate-tumor-biomarkers-in-pre-and-postmenopausal-breast-cancer-patients
#3
Danila Coradini, Annalisa Orenti, Elisabetta Venturelli, Adalberto Cavalleri, Elia Biganzoli, Saro Oriana
Objective: To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI). Methods: We investigated 120 women with primary breast cancer and median follow-up of 138 months. Serum levels of TS and SHBG and patient's BMI were evaluated before surgery...
February 21, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29474458/positive-cytoplasmic-uchl5-tumor-expression-in-gastric-cancer-is-linked-to-improved-prognosis
#4
Leena Arpalahti, Alli Laitinen, Jaana Hagström, Harri Mustonen, Arto Kokkola, Camilla Böckelman, Caj Haglund, Carina I Holmberg
Gastric cancer is the second most common cause of cancer-related mortality worldwide. Accurate prediction of disease progression is difficult, and new biomarkers for clinical use are essential. Recently, we reported that the proteasome-associated deubiquitinating enzyme UCHL5/Uch37 is a new prognostic marker in both rectal cancer and pancreatic ductal adenocarcinoma. Here, we have assessed by immunohistochemistry UCHL5 tumor expression in gastric cancer. The study cohort comprised 650 patients, who underwent surgery in Helsinki University Hospital, Finland, between 1983 and 2009...
2018: PloS One
https://www.readbyqxmd.com/read/29474271/de-escalation-treatment-of-human-papillomavirus-positive-oropharyngeal-squamous-cell-carcinoma-an-evidence-based-review-for-the-locally-advanced-disease
#5
Gustavo T Stock, Renata R C Colombo Bonadio, Gilberto de Castro
PURPOSE OF REVIEW: Oropharyngeal cancer (OPC) incidence is increasing worldwide, especially in developed countries where it seems to be etiologically related to the elevating rates of high-risk human papillomavirus (HPV) infection. Considered a distinct disease because of its weak correlation with the traditional risk factors (tobacco use and alcohol), it has different patterns of survival outcomes, locoregional and distant failure, generally with better prognosis independently of the treatment...
February 22, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29474004/image-guided-surgery-in-cancer-a-strategy-to-reduce-incidence-of-positive-surgical-margins
#6
REVIEW
Kathryn R Tringale, John Pang, Quyen T Nguyen
Primary treatment for many solid cancers includes surgical excision or radiation therapy, with or without the use of adjuvant therapy. This can include the addition of radiation and chemotherapy after primary surgical therapy, or the addition of chemotherapy and salvage surgery to primary radiation therapy. Both primary therapies, surgery and radiation, require precise anatomic localization of tumor. If tumor is not targeted adequately with initial treatment, disease recurrence may ensue, and if targeting is too broad, unnecessary morbidity may occur to nearby structures or remaining normal tissue...
February 23, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29473957/comparison-of-two-novel-staging-systems-with-the-tnm-system-in-predicting-stage-iii-colon-cancer-survival
#7
Richard Walker, Trevor Wood, Emily LeSouder, Michelle Cleghorn, Manjula Maganti, Andrea MacNeill, Fayez A Quereshy
BACKGROUND AND OBJECTIVES: Adaptations of the TNM staging system that incorporate the Lymph Node Ratio (LNR) have been proposed for stage III colon cancer. This study compared the concordance of two novel staging systems and the TNM system with observed survival outcomes in stage III patients. METHODS: A review of patients who underwent surgery for stage III colon cancer between January 2002 and April 2015 at a tertiary care centre was performed. The Kaplan-Meier method was used to estimate the 5-year overall (OS) and disease free survival (DFS) rates, and the concordance probability was calculated to evaluate the discriminatory power of the staging systems...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473947/quality-of-preoperative-pelvic-computed-tomography-ct-and-magnetic-resonance-imaging-mri-for-rectal-cancer-in-a-region-in-ontario-a-retrospective-population-based-study
#8
Jessica Bogach, Scott Tsai, Kevin Zbuk, Raimond Wong, Vanja Grubac, Angela Coates, Gregory R Pond, Marko Simunovic
BACKGROUND AND OBJECTIVES: Treatment decisions for rectal cancer rely on preoperative staging with CT and MRI scans. We assessed the quality of such scans in a region of Ontario. METHODS: We retrospectively collected data for patients undergoing rectal cancer surgery between July 2011 and December 2014. We measured three aspects of quality: use; comprehensiveness of reporting T-category, N-category, mesorectal fascia (MRF) status; and in non-radiated patients sensitivity and specificity of reports for relevant elements...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473482/prospective-surveillance-and-targeted-physiotherapy-for-arm-morbidity-after-breast-cancer-surgery-a-pilot-randomized-controlled-trial
#9
Bolette S Rafn, Stanley Hung, Alison M Hoens, Margaret L McNeely, Chiara A Singh, Winkle Kwan, Carol Dingee, Elaine C McKevitt, Urve Kuusk, Jinsi Pao, Nancy Van Laeken, Charlie H Goldsmith, Kristin L Campbell
OBJECTIVE: To evaluate prospective surveillance and targeted physiotherapy (PSTP) compared to education (EDU) on the prevalence of arm morbidity and describe the associated program cost. DESIGN: Pilot randomized single-blinded controlled trial. SETTING: Urban with assessments and treatment delivered in hospitals. PARTICIPANTS: Women scheduled for breast cancer surgery. INTERVENTIONS: Participants were randomly assigned (1:1) to PSTP ( n = 21) or EDU ( n = 20) and assessed presurgery and 12 months postsurgery...
February 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29473453/wilhelm-fabricius-von-hilden-1560-1634-the-pioneer-of-german-surgery
#10
Konstantinos Laios
Wilhelm Fabricius von Hilden (1560-1634) or also known with his Latinized name Guilielmus Fabricius Hildanus is considered the founder of scientific German surgery. He introduced new surgical techniques and invented new surgical instruments for the surgical treatment of nasal polyps, stone bladder, breast and ocular cancer, hydrocele, and ascites, while very ingenious were his amputation techniques. His most important surgical treatise was Observationem et curationem chirurgicam centuriae sex ( Six Hundred Surgical Observations and Treatments) first published in 1606...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29473452/a-new-surgical-device-for-anterograde-intraoperative-rectal-washout
#11
Fabio Rondelli, Roberto Santinelli, Paolo Stella, Walter Bugiantella, Graziano Ceccarelli, Ruben Carlo Balzarotti, Michele De Rosa, Nicola Avenia
BACKGROUND: Colorectal cancer is the fourth most diffuse cause of death in the world and local recurrence is associated with a reduced long-term life expectancy, with a reduced quality of life. Rectal washout at the anastomosis site leads to a statistically significant reduction of local recurrences. METHODS: We developed the idea of a new laparoscopic stapler with an integrated washout system that could decontaminate the rectal stump before resection, without the need to enlarge the standard surgical incision or even to distort the incision site, closing the rectal stump just below the inferior part of the cancer, and then proceeding with the resection and stapling of the distal part of the tumor...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29473376/can-re-cturbt-be-useful-in-pt1hg-disease-as-a-risk-indicator-of-recurrence-and-progression-a-single-centre-experience
#12
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Mauro Vermiglio
INTRODUCTION: Understaging after initial transurethral resection is common in patients with high-risk non muscle infiltrating bladder cancer (NMIBC) and can delay accurate diagnosis and definitive treatment. The rate of upstaging from T1 to T2 disease after repeated transurethral resection ranges from 0 to 28%, although the rate of upstaging may be even higher up to 49% when muscularis propria is absent in the first specimen. A restaging classic transurethral resection of bladder tumour (re-cTURBT) is the better predictor of early stage progression...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473340/a-nomogram-incorporating-six-easily-obtained-parameters-to-discriminate-intrahepatic-cholangiocarcinoma-and-hepatocellular-carcinoma
#13
Mengmeng Wang, Yuzhen Gao, Huijuan Feng, Elisa Warner, Mingrui An, Jian'an Jia, Shipeng Chen, Meng Fang, Jun Ji, Xing Gu, Chunfang Gao
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are the most prevalent histologic types of primary liver cancer (PLC). Although ICC and HCC share similar risk factors and clinical manifestations, ICC usually bears poorer prognosis than HCC. Confidently discriminating ICC and HCC before surgery is beneficial to both treatment and prognosis. Given the lack of effective differential diagnosis biomarkers and methods, construction of models based on available clinicopathological characteristics is in need...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29472928/immunothrombotic-activity-of-damage-associated-molecular-patterns-and-extracellular-vesicles-in-secondary-organ-failure-induced-by-trauma-and-sterile-insults
#14
REVIEW
John Eppensteiner, Robert Patrick Davis, Andrew S Barbas, Jean Kwun, Jaewoo Lee
Despite significant improvements in injury prevention and emergency response, injury-related death and morbidity continues to increase in the US and worldwide. Patients with trauma, invasive operations, anti-cancer treatment, and organ transplantation produce a host of danger signals and high levels of pro-inflammatory and pro-thrombotic mediators, such as damage-associated molecular patterns (DAMPs) and extracellular vesicles (EVs). DAMPs (e.g., nucleic acids, histone, high-mobility group box 1 protein, and S100) are molecules released from injured, stressed, or activated cells that act as endogenous ligands of innate immune receptors, whereas EVs (e...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472106/open-versus-laparoscopic-portal-lymphadenectomy-in-gallbladder-cancer-is-there-a-difference-in-lymph-node-yield
#15
Cecilia T Ong, Kenneth Leung, Daniel P Nussbaum, Zhifei Sun, Beat Gloor, Dan G Blazer, Mathias Worni
BACKGROUND: Gallbladder cancer (GBC) is the most common biliary tract malignancy. Because it commonly metastasizes via lymphatics, portal lymphadenectomy should be included in oncologic resections. This study aimed to compare the oncologic equivalence of the laparoscopic versus open technique by evaluating lymph node (LN) yield. METHODS: The 2010-2012 National Cancer Data Base identified patients who underwent laparoscopic or open resection of GBC with dedicated lymphadenectomy...
February 19, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29471883/the-extremity-localized-classic-osteosarcomas-have-better-survival-than-the-axial-non-classics
#16
Li Lin, Shaoyong Deng, Futing Zhang, Yaoze Liang, Zhenhua Huang
BACKGROUND: Osteosarcoma is one of the most malignant primary bone cancers, while is rarely reported in China. Of note, very few data of prognosis has been documented in this region. Thus, we carried a retrospective study to identify prognostic factors and to analyze outcomes in patients of both classic and non-classic high-grade osteosarcomas. Classic osteosarcoma is defined as of high-grade histology, age below 40 years, with extremity localized primary tumor, and without detectable metastasis at primary diagnosis...
February 23, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29471831/prediction-of-suboptimal-cytoreductive-surgery-in-patients-with-advanced-ovarian-cancer-based-on-preoperative-and-intraoperative-determination-of-the-peritoneal-carcinomatosis-index
#17
Antoni Llueca, Anna Serra, Isabel Rivadulla, Luis Gomez, Javier Escrig
BACKGROUND: The peritoneal carcinomatosis index (PCI) can be used to quantify the tumor burden in patients with advanced ovarian cancer. The aim of the present study was to establish a predictive model for suboptimal cytoreductive surgery (SCS) (residual tumor of > 1 cm) using preoperative and intraoperative determination of the PCI. METHODS: In total, 110 consecutive patients treated for advanced ovarian cancer during a 4-year period in our institution were assessed...
February 23, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29471618/visual-probing-of-rectal-neoplasia-near-infrared-interrogation-of-primary-tumours-and-secondary-lymph-nodes
#18
Haseeb A Khokhar, Eamon Loughman, Moataz Khogali, Niall Mulligan, Donal F O'Shea, Ronan A Cahill
Laparoscopic and endoscopic colorectal intervention and operations have their basis in real-time, image-based decision-making and step-by-step sequenced technical progress. The capacity to visualise accurately malignant disease wherever it may be including within the primary lesion and its draining lymph node basin as well as at potential sites of metastatic harbour (i.e. peritoneum, liver and lung) would allow more accurate surgery at the time of operation and enable personalised, stratified surgical intervention...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29471617/how-to-reduce-surgical-complications-in-rectal-cancer-surgery-using-fluorescence-techniques
#19
Elisa Cassinotti, Stefano Costa, Stefano DE Pascale, Barbara Oreggia, Giorgio Palazzini, Luigi Boni
BACKGROUND: Anastomotic leakage (AL) is a serious complication in colorectal surgery leading to significant morbidity and mortality. Progressively lower anastomoses are associated with a greater leak rate. Adequate bowel perfusion has been stressed as one of the key elements for suture healing. Currently, there is no widespread method to assess and quantify the perfusion of gastrointestinal anastomoses intraoperatively, besides the subjective evaluation by the surgeon. The aim of this paper is to describe the basis of Indocyanine Green (ICG) fluorescence guided surgery applied to assessment of bowel perfusion and to highlight studies on the use of fluorescence angiography (FA) in laparoscopic rectal surgery...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29471616/non-operative-management-of-rectal-cancer-future-perspectives-turning-into-reality
#20
Nicolò DE Manzini, Gabriele Bellio, Pio Corleone, Marina Troian
The management of rectal cancer has considerably changed over the last decades and complete response to neoadjuvant chemoradiotherapy is becoming a common clinical entity. There is still no consensus on the definition of complete response to neoadjuvant treatment prior to surgery. Treatment programs are mostly heterogeneous and non-randomized. In addition, techniques to diagnose complete response are still unclear and there is no uniformity in surveillance modality of those patients managed without operative intervention...
February 21, 2018: Minerva Chirurgica
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