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Platelet rich plasma hyaluronic

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https://www.readbyqxmd.com/read/28501713/an-in-situ-photocrosslinkable-platelet-rich-plasma-complexed-hydrogel-glue-with-growth-factor-controlled-release-ability-to-promote-cartilage-defect-repair
#1
Xiaolin Liu, Yunlong Yang, Xin Niu, Qiuning Lin, Bizeng Zhao, Yang Wang, Linyong Zhu
The repair of articular cartilage injury is a great clinical challenge. Platelet-rich plasma (PRP) has attracted much attention for the repair of articular cartilage injury, because it contains various growth factors that are beneficial for wound repair. However, current administration methods of PRP face many shortcomings, such as unstable biological fixation and burst release of growth factors, all of which will bring troubles to its application in the repair of articular cartilage and compromise its therapeutic efficacy...
May 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28459641/hyaluronic-acid-versus-platelet-rich-plasma-letter-to-the-editor
#2
Gregory A Brown, David S Jevsevar, Kevin G Shea, Robert H Quinn
No abstract text is available yet for this article.
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28459640/hyaluronic-acid-versus-platelet-rich-plasma-response
#3
Brian J Cole, Vasili Karas, Lisa A Fortier
No abstract text is available yet for this article.
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28435559/intra-articular-hyaluronic-acid-ha-and-platelet-rich-plasma-prp-injection-versus-hyaluronic-acid-ha-injection-alone-in-patients-with-grade-iii-and-iv-knee-osteoarthritis-oa-a-retrospective-study-on-functional-outcome
#4
C Saturveithan, G Premganesh, S Fakhrizzaki, M Mahathir, K Karuna, K Rauf, H William, H Akmal, N Sivapathasundaram, K Jaspreet
Introduction: Intra-articular hyaluronic acid (HA) is widely utilized in the treatment of knee osteoarthritis whereas platelet rich plasma (PRP) enhances the regeneration of articular cartilage. This study analyses the efficacy of HA and PRP in grade III and IV knee osteoarthritis. Methodology: This is a cross sectional study with retrospective review of 64 patients (101 knees) which includes 56 knees injected with HA+ PRP, and 45 knees with HA only. Results: During the post six months International Knee Documentation Committee (IKDC) evaluation, HA+PRP group showed marked improvement of 24...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28409101/microdrilling-surgery-augmented-with-intra-articular-bone-marrow-aspirate-concentrate-platelet-rich-plasma-and-hyaluronic-acid-a-technique-for-cartilage-repair-in-the-knee
#5
Joseph E Broyles, M Adaire O'Brien, M Patrick Stagg
The ideal treatment of large full-thickness chondral lesions in the knee, especially "kissing lesions" and osteoarthritis, has not been determined. Microdrilling surgery augmented with injections of peripheral blood stem cells and hyaluronic acid has been used to treat patients with a wide range of articular cartilage disease including patients with bipolar lesions and joint space narrowing. Excellent results in this difficult patient population have been reported, and second-look biopsy has shown repair tissue very similar to native hyaline cartilage...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28400868/use-of-saline-as-a-placebo-in-intra-articular-injections-in-osteoarthritis-potential-contributions-to-nociceptive-pain-relief
#6
REVIEW
David Bar-Or, Leonard T Rael, Edward N Brody
BACKGROUND: Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have succeeded to varying degrees either with sodium hyaluronate preparations or with a biologic. OBJECTIVE: The objective of this review is to evaluate multiple studies that demonstrate some relief from the symptoms of OAK in the saline arm of various clinical trials...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28398969/efficacy-of-platelet-rich-plasma-in-pain-and-self-report-function-in-knee-osteoarthritis-a-best-evidence-synthesis
#7
Zhongwei Xu, Jiao Luo, Xiao Huang, Bin Wang, Jian Zhang, Aiguo Zhou
OBJECTIVE: The aim of this study was to assess the efficacy of platelet-rich plasma (PRP) in pain and self-report function of patients with knee osteoarthritis on the basis of comparisons with hyaluronic acid or placebo. DESIGN: Best-evidence synthesis of randomized controlled trials (RCTs) was conducted. Literature retrieval was limited to RCTs assessing the efficacy of PRP in knee osteoarthritis. Methodology evaluation and data extraction were based on Cochrane Collaboration guidelines...
April 8, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28386761/platelet-rich-plasma-for-the-management-of-hip-and-knee-osteoarthritis
#8
REVIEW
Kim L Bennell, David J Hunter, Kade L Paterson
PURPOSE OF REVIEW: Knee and hip osteoarthritis (OA) are major public health problems worldwide causing pain, disability and impaired quality of life. This narrative paper discusses platelet-rich plasma (PRP) as a treatment for hip and knee OA, with a focus on evidence from randomised controlled trials (RCTs). RECENT FINDINGS: Since the first RCT of PRP in 2012, there has been 15 RCTs in knee OA and three in hip OA, mostly comparing PRP to another intra-articular injection therapy, hyaluronic acid...
May 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28322719/prp-in-oa-knee-update-current-confusions-and-future-options
#9
Mandeep S Dhillon, Sandeep Patel, Rakesh John
Positive results have been uniformly observed by various researchers for platelet-rich plasma (PRP) in early osteoarthritis (OA) knee in the past few years. PRP has clearly demonstrated its supremacy in comparison to hyaluronic acid (HA) and placebo in various clinical trials and is undoubtedly the best option available for symptomatic treatment in early OA. The release of growth factors from PRP occurs immediately and lasts for around three weeks and the clinical effect tends to wane down by the end of the year...
2017: SICOT-J
https://www.readbyqxmd.com/read/28320211/corrigendum
#10
(no author information available yet)
Cole BJ, Karas V, Hussey K, Merkow DB, Pilz K, Fortier LA. Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. Am J Sports Med. 2017;45(2):339-346. (Original DOI: 10.1177/0363546516665809 ).
April 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#11
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28259349/editorial-commentary-the-time-has-come-to-try-intra-articular-platelet-rich-plasma-injections-for-your-patients-with-symptomatic-knee-osteoarthritis
#12
EDITORIAL
Timothy J Hunt
Platelet-rich plasma injections, in a systematic review and meta-analysis of 10 Level I randomized control trials, were found to provide more pain relief and better functional outcomes than hyaluronic acid in patients with knee osteoarthritis at 12 months after injection. The time has come for those of us who have not yet tried platelet-rich plasma injections in our patients with symptomatic knee osteoarthritis to do so.
March 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28237253/comparison-of-intra-articular-injection-of-plasma-rich-in-growth-factors-versus-hyaluronic-acid-following-arthroscopy-in-the-treatment-of-temporomandibular-dysfunction-a-randomised-prospective-study
#13
Martín Fernández-Ferro, Jacinto Fernández-Sanromán, Andrés Blanco-Carrión, Alberto Costas-López, Annahys López-Betancourt, Jorge Arenaz-Bua, Bogdan Stavaru Marinescu
PURPOSE: The main objective of our study was to evaluate the effectiveness of the injection of plasma rich in platelet-derived growth factors (PRGF) versus hyaluronic acid (HA) following arthroscopic surgery in patients diagnosed with internal derangement of the temporomandibular joint (TMJ) with osteoarthritis (OA). MATERIALS AND METHODS: A total of 100 patients were randomised into two study groups. Group A (n = 50) received an injection of PRGF, and Group B (n = 50) received an injection of HA...
April 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28146403/hyaluronic-acid-versus-platelet-rich-plasma-a-prospective-double-blind-randomized-controlled-trial-comparing-clinical-outcomes-and-effects-on-intra-articular-biology-for-the-treatment-of-knee-osteoarthritis
#14
Brian J Cole, Vasili Karas, Kristen Hussey, Kyle Pilz, Lisa A Fortier
BACKGROUND: The use of platelet-rich plasma (PRP) for the treatment of osteoarthritis (OA) has demonstrated mixed clinical outcomes in randomized controlled trials when compared with hyaluronic acid (HA), an accepted nonsurgical treatment for symptomatic OA. Biological analysis of PRP has demonstrated an anti-inflammatory effect on the intra-articular environment. PURPOSE: To compare the clinical and biological effects of an intra-articular injection of PRP with those of an intra-articular injection of HA in patients with mild to moderate knee OA...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28019703/clinically-relevant-hydrogel-based-on-hyaluronic-acid-and-platelet-rich-plasma-as-a-carrier-for-mesenchymal-stem-cells-rheological-and-biological-characterization
#15
Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Matteo D'Este, Caterina Cattani, Giuseppina Catanzaro, Maria Cristina Tirindelli, Lorenza Lazzari, Mauro Alini, Rosaria Giordano, Vincenzo Denaro
Intervertebral disc regeneration is quickly moving towards clinical applications. However, it is still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new injectable hydrogel composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed to generate a clinically relevant cell carrier for disc regeneration. PRP/HA/BTX blend was tested for rheological properties. Amplitude sweep, frequency sweep, and rotational measurements were performed and viscoelastic properties were evaluated...
December 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28012636/efficacy-of-platelet-rich-plasma-in-the-treatment-of-knee-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#16
Wen-Li Dai, Ai-Guo Zhou, Hua Zhang, Jian Zhang
PURPOSE: To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections for the treatment knee of osteoarthritis (OA). METHODS: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane database through April 2016 to identify Level I randomized controlled trials that evaluated the clinical efficacy of PRP versus control treatments for knee OA. The primary outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores...
March 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28002896/comparing-hybrid-hyaluronic-acid-with-prp-in-end-career-athletes-with-degenerative-cartilage-lesions-of-the-knee
#17
R Papalia, B Zampogna, F Russo, S Vasta, M C Tirindelli, C Nobile, A C Di Martino, G Vadalà, V Denaro
Cartilage lesions are very common causes of chronic knee pain in athletes. Current treatment options consist in conservative strategies, such as viscosupplementation and platelet-rich plasma injections. This randomized controlled trial aims to investigate the effect of intra-articular Hybrid Hyaluronic Acid injections compared to PRP for the treatment of cartilage lesions among athletes at the end of their career. Since March 2015, 48 professional soccer players were randomized into two groups: 24 patients received 3 injections of HHA and 23 patients received 3 intra-articular injections of PRP...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27992290/patient-reported-outcomes-following-platelet-rich-plasma-injections-in-treating-osteochondral-lesions-of-the-talus-a-critically-appraised-topic
#18
Samuel F Jazzo, Daniel Scribner, Stephanie Shay, Kyung-Min Kim
Clinical Scenario: Osteochondral lesions (OCLs) of the talus can result from ankle sprains which are the most common injury in the physically active. Recently, Platelet-rich Plasma (PRP) has been used to develop an innovate treatment for OCLs of the Talus. CLINICAL QUESTION: Do PRP injections improve self-reported pain and ankle function in patients with OCL of the talus? Summary of Key Findings: Three randomized-controlled trials were included. One of the studies compared a single dose of PRP to a single dose of hyaluronic acid (HA) or saline when added as an adjunct to microfracture surgery...
December 19, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27924172/hyaluronic-acid-fat-graft-myringoplasty-versus-autologous-platelet-rich-plasma
#19
Salman F Alhabib, Issam Saliba
BACKGROUND: Hyaluronic acid fat graft myringoplasty (HAFGM) is an office-based technique for tympanic membrane perforation (TMP) treatment. It is simple, inexpensive, and performed under local anesthesia at the outpatient office department. We aimed to compare HAFGM technique to a recently described topical use of autologous platelet rich plasma myringoplasty (PRPM) in the repair of TMP. We also aimed to assess the hearing level improvement postoperatively. METHODS: We conducted a prospective study in an adult tertiary care center between January 2015 and January 2016...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27680608/comparison-of-the-effects-of-prp-and-hyaluronic-acid-in-promoting-peripheral-nerve-regeneration-an-experimental-study-with-vascular-conduit-model-in-rats
#20
Cemal Firat, Ahmet Hamdi Aytekin, Mehmet Akif Durak, Yilmaz Geyik, Serkan Erbatur, Metin Dogan, Omer Elmas, Adile Ferda Dagli, Hamit Celik
AIM: Peripheral nerve defects generally occur due to mechanical, chemical, thermal and pathologic causes and the reconstruction is still a challenging problem. In the present study, we aimed to compare the effects of platelet rich plasma (PRP) that has high levels of growth factors and hyaluronic acid (HA) that is known to have positive effects on nerve regeneration by decreasing scar formation in a rat model where they were injected through allogeneic aorta graft in peripheral nerve defects using histopathologic and functional methods...
2016: Annali Italiani di Chirurgia
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