Jamie Lee, Joshua Zhang, Maeve Flanagan, Julian A Martinez, Christopher Cunniff, Nicole Kucine, Ake T Lu, Amin Haghani, Juozas Gordevičius, Steve Horvath, Vivian Y Chang
Bloom syndrome (BSyn) is an autosomal recessive disorder caused by variants in the BLM gene, which is involved in genome stability. Patients with BSyn present with poor growth, sun sensitivity, mild immunodeficiency, diabetes, and increased risk of cancer, most commonly leukemias. Interestingly, patients with BSyn do not have other signs of premature aging such as early, progressive hair loss and cataracts. We set out to determine epigenetic age in BSyn, which can be a better predictor of health and disease over chronological age...
August 18, 2023: Aging Cell