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asthma pathophysiology

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https://www.readbyqxmd.com/read/29676068/trpv1-blocking-alleviates-airway-inflammation-and-remodeling-in-a-chronic-asthma-murine-model
#1
Joon Young Choi, Hwa Young Lee, Jung Hur, Kyung Hoon Kim, Ji Young Kang, Chin Kook Rhee, Sook Young Lee
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1 (TRPV1) channel in the pathophysiology of asthma. This study examined whether TRPV1 antagonism alleviates asthma features in a murine model of chronic asthma. METHODS: BALB/c mice were sensitized to and challenged by ovalbumin to develop chronic asthma...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29672178/obese-and-allergic-related-asthma-phenotypes-among-children-across-the-united-states
#2
Mindy K Ross, Tahmineh Romero, Myung S Sim, Peter G Szilagyi
OBJECTIVES: Pediatric asthma is heterogeneous with phenotypes that reflect differing underlying inflammation and pathophysiology. Little is known about the national prevalence of certain obesity and allergy related asthma phenotypes or associated characteristics. We therefore assessed the national prevalence, risk factors, and parent-reported severity of four asthma phenotypes: not-allergic-not-obese, allergic-not-obese, obese-not-allergic, and allergic-and-obese. METHODS: We analyzed data from the 2007-2008 National Survey of Children's Health (NSCH) of 10-17 year-olds with parent-reported asthma...
April 19, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29665658/effect-of-the-anti-il-17-antibody-on-allergic-inflammation-in-an-obesity-related-asthma-model
#3
Lin Liang, Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee
Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in obese patients by inhibiting interleukin 17 (IL-17) expression. This study investigated the combined effects of pravastatin and anti-IL-17 antibody treatment on allergic inflammation in a mouse model of obesity-related asthma...
April 19, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29642688/samter-s-triad-state-of-the-art
#4
Sung-Dong Kim, Kyu-Sup Cho
Samter's triad (ST) is a well-known disease characterized by the triad of bronchial asthma, nasal polyps, and aspirin intolerance. Over the past few years, a rapid development in the knowledge of the pathogenesis and clinical characteristics of ST has happened. The aim of this paper is to review the recent investigations on the pathophysiological mechanisms and genetic background, diagnosis, and different therapeutic options of ST to advance our understanding of the mechanism and the therapeutic control of ST...
April 13, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29624776/trpc3-overexpression-and-intervention-in-airway-smooth-muscle-of-ovalbumin-induced-hyperresponsiveness-and-remodeling
#5
Bo-Ming Xu, Jia-Hua Zhang, Jia-Ling Wang, Jun-Hua Xiao
Transient receptor potential canonical channel 3 (TRPC3) proteins function as non-voltage-gated Ca2+ -permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression and airway hyperresponsiveness and remodeling in ovalbumin-induced asthmatic Kunming mice. Mice were sensitized and challenged by ovalbumin to establish asthmatic model. Hematoxylin-eosin staining, hydroxyproline assay and isometric tracheal ring force measurement were used to evaluate airway remodeling and hyperresponsiveness in asthmatic mice...
April 6, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29611440/new-biologics-for-allergic-diseases
#6
Laurie A Manka, Michael E Wechsler
Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas Covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation...
April 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29604204/kallikrein-related-peptidases-in-lung-diseases
#7
Woodys Lenga Ma Bonda, Sophie Iochmann, Mélia Magnen, Yves Courty, Pascale Reverdiau
Human tissue kallikreins (KLKs) are 15 members of the serine protease family and are present in various healthy human tissues including airway tissues. Multiple studies have revealed their crucial role in the pathophysiology of a number of chronic, infectious and tumour lung diseases. KLK1, 3 and 14 are involved in asthma pathogenesis, and KLK1 could be also associated with the exacerbation of this inflammatory disease caused by rhinovirus. KLK5 was demonstrated as an influenza virus activating protease in humans, and KLK1 and 12 could also be involved in the activation and spread of these viruses...
March 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29601152/combat-zone-exposure-and-respiratory-tract-disease
#8
REVIEW
Sean M Parsel, Charles A Riley, Edward D McCoul
BACKGROUND: The impact of deployment to combat zones on the respiratory and sinonasal health of U.S. soldiers is an emerging public health concern. Retrospective studies have shown a correlation between deployment and development of post-deployment pathology, particularly of the aerodigestive system. Respiratory disease, including sinusitis, allergic rhinitis, and asthma, are commonly reported in soldiers deployed to the Middle East and Southwest Asia. METHODS: Current literature pertaining to combat zone exposure and development of respiratory disease was retrieved using PubMed, Embase, Web of Science, and Google Scholar...
March 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29597194/fc%C3%AE-riiia-negatively-impacts-humoral-immune-responses-but-not-overall-lung-inflammation-in-an-ovalbumin-induced-allergic-asthma-mouse-model
#9
Pingping Zhou, Tongqian Wu, Xiaoqian Jin, Jing Li, Haijian Yan, Ling Zhou, Yali Huang, Jun Wang, Haiyan Zhou, Xiaoping Zhu, Xiang Zou, Yu Fang
BACKGROUND: Fcγ receptors (FcγR) play substantial immune regulatory roles both positively and negatively in pathophysiological processes including allergy and asthma. Compared with FcγRIIB which is classically defined as an inhibitory receptor, mouse FcγRIIIA and its functional human homologue FcγRIIA have been assumed to be activating receptors. However, evidence demonstrating inhibitory regulation by mouse FcγRIIIA has recently been emerging. OBJECTIVE: To dissect the contributory roles of mouse FcγRIIIA (human FcγRIIA) in parallel with FcγRIIB in an ovalbumin (OVA)-induced mouse model of asthma and to preliminarily assess the correlation of the respective FcγR with circulating IgE levels in human asthma patients...
March 29, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29574758/childhood-asthma-clusters-reveal-neutrophil-predominant-phenotype-with-distinct-gene-expression
#10
Ming-Wei Su, Wen-Chang Lin, Ching-Hui Tsai, Bor-Luen Chiang, Yao-Hsu Yang, Yu-Tsan Lin, Li-Chieh Wang, Jyh-Hong Lee, Chen-Cheng Chou, Yi-Fan Wu, Yu-Liang Yeh, Yungling L Lee
BACKGROUND: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments. METHODS: We applied k-means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene expression profiles of peripheral blood mononuclear cells (PBMC) from children with different asthma phenotypes...
March 25, 2018: Allergy
https://www.readbyqxmd.com/read/29573220/depleted-iron-stores-are-associated-with-inspiratory-muscle-weakness-independently-of-skeletal-muscle-mass-in-men-with-systolic-chronic-heart-failure
#11
Michał Tkaczyszyn, Marcin Drozd, Kinga Węgrzynowska-Teodorczyk, Irena Flinta, Kamil Kobak, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska
BACKGROUND: Skeletal and respiratory muscle dysfunction constitutes an important pathophysiological feature of heart failure (HF). We assessed the relationships between respiratory muscle function, skeletal muscle mass, and physical fitness in men with HF with reduced left ventricular ejection fraction (HFrEF), and investigated the hypothesis of whether iron deficiency (ID) contributes to respiratory muscle dysfunction in these patients. METHODS: We examined 53 male outpatients with stable HFrEF without asthma or chronic obstructive pulmonary disease (age: 64 ± 10 years; New York Heart Association [NYHA] class I/II/III: 36/51/13%; ischaemic aetiology: 83%; all with left ventricular ejection fraction ≤40%) and 10 middle-aged healthy men (control group)...
March 23, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29572197/nod-2-expression-dna-damage-and-oxido-inflammatory-status-in-egyptian-patients-with-atopic-bronchial-asthma-exploring-their-nexus-to-disease-severity
#12
Hanaa H Gaballah, Rasha A Gaber, Ragia S Sharshar, Samah A Elshweikh
BACKGROUND: Allergic asthma is a chronically relapsing inflammatory airway disease with a complex pathophysiology. AIM: This study was undertaken to investigate the potential contribution of NOD2 signaling, proinflammatory cytokines, chitotriosidase (CHIT1) activity, oxidative stress and DNA damage to atopic asthma pathogenesis, as well as to explore their possible role as surrogate noninvasive biomarkers for monitoring asthma severity. METHODS: Sixty patients with atopic bronchial asthma who were divided according to asthma severity into 40 mild-moderate, 20 severe atopic asthmatics, in addition to thirty age-matched healthy controls were enrolled in this study...
March 20, 2018: Gene
https://www.readbyqxmd.com/read/29568538/inhalation-of-hydrogen-gas-attenuates-airway-inflammation-and-oxidative-stress-in-allergic-asthmatic-mice
#13
Ning Zhang, Changwen Deng, Xingxing Zhang, Jingxi Zhang, Chong Bai
Background: Asthma is a worldwide common chronic airway disease that cannot be cured and results in the huge burden in public health. Oxidative stress was considered an important mechanism in the pathogenesis of asthma. Hydrogen gas been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases and the function of this nontoxic gas in asthma was unclear. The purpose of the study aims to examine the effect of inhalation hydrogen gas on the pathophysiology of a mouse model of asthma...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29565501/the-relationship-between-muc5ac-high-secretion-and-munc18b-upregulation-in-obese-asthma
#14
W-M Hao, S-F Sun, H-P Tang
OBJECTIVE: Mucus production and hypersecretion are important pathophysiological features of asthma. Airway mucus secretion is more serious in obese asthma. Therefore, it is of great significance to elucidate the mechanism of asthma airway mucus high secretion in improving the control of asthma and the prognosis of obese asthmatic patients. MATERIALS AND METHODS: Obese asthmatic mice model was established to test the airway resistance and mucin secretion by hematoxylin-eosin (HE) staining...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29564208/subtyping-of-polyposis-nasi-phenotypes-endotypes-and-comorbidities
#15
REVIEW
Michael Koennecke, Ludger Klimek, Joaquim Mullol, Philippe Gevaert, Barbara Wollenberg
Background: Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification for this disorder. A phenotype classification according to CRS with (CRSwNP) and without polyposis (CRSsNP) is usually made. However, a large number of studies have shown that there are also different endotypes of CRS within these phenotypes, with different pathophysiologies of chronic inflammation of the nasal mucosa...
2018: Allergo Journal International
https://www.readbyqxmd.com/read/29551279/epidemiology-of-asthma-chronic-obstructive-pulmonary-disease-overlap-aco
#16
REVIEW
Akifumi Uchida, Kohta Sakaue, Hiromasa Inoue
The term "asthma-COPD overlap" (ACO) has been applied to the condition in which a person has persistent airflow limitation with clinical features of both asthma and COPD. The certain definition and diagnostic criteria for ACO have not yet been established, and ACO prevalence has varied widely in studies: from 0.9% to 11.1% in the general population, from 11.1% to 61.0% in asthma patients, and from 4.2% to 66.0% in COPD patients. Furthermore, the frequency of exacerbations and prognosis in ACO patients have not been clearly demonstrated...
March 15, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29550368/asthma-and-copd-overlap-pathophysiology-of-aco
#17
REVIEW
Mari Hikichi, Shu Hashimoto, Yasuhiro Gon
Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as asthma-COPD overlap includes several different clinical phenotypes and there are likely to be several different underlying mechanisms"...
March 14, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29550078/nasal-polyposis-pathophysiology-endotype-and-phenotype-open-issues
#18
REVIEW
Giuseppe Brescia, Claudia Zanotti, Daniela Parrino, Umberto Barion, Gino Marioni
PURPOSE: Endotyping chronic rhinosinusitis with nasal polyps (CRSwNP) poses a challenge for rhinologists nowadays. Phenotyping CRSwNP proved inappropriate as an approach to their classification because of their common clinical features. Endotyping, being based on the pathogenic mechanism, provides a precise picture more appropriate for use in clinical practice. Patients' treatment and follow-up can thus be tailored to cope with the degree of aggressiveness of a specific CRSwNP endotype...
March 7, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29514744/association-between-blood-eosinophil-count-with-asthma-hospital-readmissions
#19
Francisco-Javier Gonzalez-Barcala, Maria-Esther San-Jose, Juan-José Nieto-Fontarigo, Jose-Martín Carreira, Uxio Calvo-Alvarez, Maria-Jesus Cruz, David Facal, Maria-Teresa Garcia-Sanz, Luis Valdes-Cuadrado, Francisco-Javier Salgado
INTRODUCTION: The presence of eosinophils in asthma inflammation is a relevant factor in the pathophysiology of the disease, however the relationship between the blood eosinophil count (BEC) with asthma severity and prognosis is still under debate. The aim of this work is to analyze the relationship between the BEC levels and hospital readmissions in patients with asthma. MATERIAL AND METHODS: A review was retrospectively carried out on all admissions of patients over 18 years old due to exacerbation of asthma occurring in our hospital between the years 2000 and 2010...
March 4, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29482867/-asthma-and-the-microbiome
#20
REVIEW
C Barnig, C Martin
INTRODUCTION: It has been demonstrated recently that the respiratory tract, considered for a long time to be sterile in the healthy subject, contains a vast community of bacteria called the respiratory microbiome. This microbiome, like the intestinal microbiome, is in constant interaction with the immune system of the human host. This relationship has allowed us to formulate some new theories on the pathophysiology of asthma. BACKGROUND: The respiratory microbiome of the asthmatic differs quantitatively and qualitatively from that of the healthy subject...
February 23, 2018: Revue des Maladies Respiratoires
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