keyword
MENU ▼
Read by QxMD icon Read
search

Environmental ilnesses

keyword
https://www.readbyqxmd.com/read/28531207/benzo-a-pyrene-activates-interleukin-6-induction-and-suppresses-nitric-oxide-induced-apoptosis-in-rat-vascular-smooth-muscle-cells
#1
Huei-Ping Tzeng, Kuo-Cheng Lan, Ting-Hua Yang, Min-Ni Chung, Shing Hwa Liu
Benzo[a]pyrene, a ubiquitous environmental pollutant, has been suggested to be capable of initiating and/or accelerating atherosclerosis. Accumulation of vascular smooth muscle cells (VSMCs) in vessel intima is a hallmark of atherosclerosis. Nitric oxide (NO) can suppress VSMCs proliferation and induce VSMCs apoptosis. NO plays a compensatory role in the vascular lesions to reduce proliferation and/or accelerate apoptosis of VSMCs. The aim of this study was to investigate whether benzo[a]pyrene can affect VSMCs growth and apoptosis induced by NO...
2017: PloS One
https://www.readbyqxmd.com/read/28529118/early-life-allergen-and-air-pollutant-exposures-alter-longitudinal-blood-immune-profiles-in-infant-rhesus-monkeys
#2
Candace M Crowley, Justin H Fontaine, Joan E Gerriets, Edward S Schelegle, Dallas M Hyde, Lisa A Miller
Early life is a critical period for the progressive establishment of immunity in response to environmental stimuli; the impact of airborne challenges on this process is not well defined. In a longitudinal fashion, we determined the effect of episodic house dust mite (HDM) aerosol and ozone inhalation, both separately and combined, on peripheral blood immune cell phenotypes and cytokine expression from 4 to 25weeks of age in an infant rhesus monkey model of childhood development. Immune profiles in peripheral blood were compared with lung lavage at 25weeks of age...
May 18, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28527337/improved-stress-tolerance-and-productivity-in-transgenic-rice-plants-constitutively-expressing-the-oryza-sativa-glutathione-synthetase-osgs-under-paddy-field-conditions
#3
Seong-Im Park, Young-Saeng Kim, Jin-Ju Kim, Ji-Eun Mok, Yul-Ho Kim, Hyang-Mi Park, Il-Sup Kim, Ho-Sung Yoon
Reactive oxygen species, which increase under various environmental stresses, have deleterious effects on plants. An important antioxidant, glutathione, is used to detoxify reactive oxygen species in plant cells and is mainly produced by two enzymes: gamma-glutamylcysteine synthetase (γ-ECS) and glutathione synthetase (GS). To evaluate the functional roles of the glutathione synthetase gene (OsGS) in rice, we generated four independent transgenic rice plants (TG1-TG4) that overexpressed OsGS under the control of the constitutively expressed OsCc1 promoter...
May 10, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28525895/dietary-zno-nanoparticles-alters-intestinal-microbiota-and-inflammation-response-in-weaned-piglets
#4
Tian Xia, Wenqing Lai, Miaomiao Han, Meng Han, Xi Ma, Liying Zhang
The present study was carried out to determine whether low dose of zinc oxide nanoparticles (Nano-ZnO) could serve as a potential substitute of pharmacological dose of traditional ZnO in weaned piglets. 180 crossbred weaning piglets were randomly assigned to 3 treatments. Experimental animals were fed basal diet supplemented with 0 mg Zn/kg (Control), 600 mg Zn/kg (Nano-ZnO) and 2000 mg Zn/kg (ZnO) for 14 days. On day 14 after weaning, the piglets fed Nano-ZnO did not differ from those fed traditional ZnO in growth performance and jejunal morphology, while Nano-ZnO treatment could significantly alleviate the incidence of diarrhea (P < 0...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524018/comparison-of-the-immune-responses-associated-with-experimental-bovine-mastitis-caused-by-different-strains-of-escherichia-coli
#5
Shlomo E Blum, Elimelech D Heller, Shamay Jacoby, Oleg Krifucks, Gabriel Leitner
We studied the mammary immune response to different mammary pathogenic Escherichia coli (MPEC) strains in cows, hypothesising that the dynamics of response would differ. E. coli is a major aetiologic agent of acute clinical bovine mastitis of various degrees of severity with specific strains being associated with persistent infections. We compared challenge with three distinct pathogenic MPEC strains (VL2874, VL2732 and P4), isolated from different forms of mastitis (per-acute, persistent and acute, respectively)...
May 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28522008/chitosan-chondroitin-sulfate-hydrogels-prepared-in-hmim-hso4-ionic-liquid
#6
Cátia S Nunes, Kessily B Rufato, Paulo R Souza, Elizângela A M S de Almeida, Michael J V da Silva, Débora B Scariot, Celso V Nakamura, Fernanda A Rosa, Alessandro F Martins, Edvani C Muniz
[Hmim][HSO4] ionic liquid (IL) and bio-renewable sources as chitosan (CHT) and chondroitin sulfate (CS) were used to yield hydrogel-based materials (CHT/CS). The use of IL to solubilize both polysaccharides was considered an innovative way based on "green chemistry" principle, aiming the production of CHT/CS blended systems. CHT/CS hydrogels were carried out in homogeneous medium from short dissolution times. The hydrogels were characterized and achieved with excellent stabilities (in the 1.2-10pH range), larger swelling capacities, as well as devoid of cytotoxicity towards the normal VERO and diseased HT29 cells...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28521627/disseminated-bacillus-calmette-gu%C3%A3-rin-osteomyelitis-in-twin-sisters-related-to-stat1-gene-deficiency
#7
Sabah Boudjemaa, Linda Dainese, Sébastien Héritier, Caroline Masserot, Samia Hachemane, Jean-Laurent Casanova, Aurore Coulomb, Jacinta Bustamante
Mendelian susceptibility to mycobacterial disease is a rare syndrome characterized by severe clinical infections usually caused by weakly virulent mycobacterial species such as Bacillus Calmette-Guérin vaccines and environmental nontuberculous mycobacteria or more virulent mycobacteria as mycobacterium tuberculosis. Since 1996, 9 genes including 7 autosomal ( STAT1, IFNGR1, IFNGR2, IL12B, IL12RB1, ISG15, and IRF8) and 2 X-linked genes ( NEMO and CYBB) have been identified. Allelic heterogeneity leaded to recognize about 18 genetic diseases with variable clinical phenotypes, but sharing a same physiological mechanism represented by a defect in human IL-12-dependant-INF-γ-mediated immunity...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28514764/trim32-affects-the-recovery-of-motor-function-following-spinal-cord-injury-through-regulating-proliferation-of-glia
#8
Qiang Fu, Ming-Ming Zou, Jian-Wei Zhu, Yan Zhang, Wen-Jin Chen, Mei Cheng, Chun-Feng Liu, Quan-Hong Ma, Ru-Xiang Xu
Both the extrinsic environmental factors and intrinsic neuronal mechanisms limit the axonal regeneration after spinal cord injury (SCI). However, the underlying molecular mechanisms remain unclear. In the present study, we identify tripartite motif protein 32 (TRIM32), an E3 ubiquitin ligase, which is barely detected in glial cells in the normal uninjured spinal cord, exhibits strong expression in both astrocytes and microglia following SCI. We further observe that deficiency of TRIM32 results in increased numbers of astrocytes and microglia, which is accompanied by enhanced proliferation of both cells and increased secretion of interleukin (IL)-1 and IL-10...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514348/-dynamics-of-immunological-features-of-oral-liquid-in-children-with-chronic-catarrhal-gingivitis-living-on-polluted-territories-with-fluoride-and-iodine-deficiency
#9
N V Malko, E V Besvushko
The aim of the study was to assess the state of oral liquid (OL) immunity in children with chronic catarrhal gingivitis (CCG) living in adverse environmental conditions. 120 children aged 7-15 residing in ecologically unfavorable areas of Lviv region were examined, while 75 children living in 'relatively clean' region were involved in the control group. Chronic catarrhal gingivitis was diagnosed according to Danilevskiy classification (1994). The level of cytokines in oral liquid of 7-years-old children living in ecologically polluted region (EPR), was (198...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28512631/genetic-alterations-in-gastric-cancer-associated-with-helicobacter-pylori-infection
#10
REVIEW
Claudia I Rivas-Ortiz, Yolanda Lopez-Vidal, Luis Jose Rene Arredondo-Hernandez, Gonzalo Castillo-Rojas
Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. The aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. Genetic variants, polymorphisms, desoxyribonucleic acid methylation, and genes involved in mediating inflammation have been associated with the development of gastric carcinogenesis...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28495853/transgenerational-transmission-of-asthma-risk-after-exposure-to-environmental-particles-during-pregnancy
#11
David J Gregory, Lester Kobzik, Zhiping Yang, Connor C McGuire, Alexey V Fedulov
Exposure to environmental particles during pregnancy increases asthma susceptibility of the offspring. We tested the hypothesis that this transmission continues to F2 and F3 generations and occurs via epigenetic mechanisms. We compared allergic susceptibility of three generations of BALB/c offspring after a single maternal exposure during pregnancy to diesel exhaust particles or concentrated urban air particles. After pregnant dams received intranasal instillations of particle suspensions or control, their F1, F2 and F3 offspring were tested in a low-dose ovalbumin protocol for allergy sensitivity...
May 11, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28495847/inflammatory-responses-to-acute-elevations-of-carbon-dioxide-in-mice
#12
Stephen R Thom, Veena M Bhopale, Jingping Hu, Ming Yang
Health risks are described from elevated indoor air carbon dioxide (CO2), which often ranges from 1000 to 4000 parts per million (ppm), but mechanisms are unknown. Here, we demonstrate that mice exposed for 2 hours to 2000 or 4000 ppm CO2 exhibit, respectively, 3.4 + 0.9 (SE, n=6) and 4.1 + 0.7 (n=10)-fold elevations in circulating microparticles (MPs); neutrophil and platelet activation and vascular leak in brain, muscle and distal colon. Interleukin (IL)-1β content of MPs also increases after 2000 ppm by 3...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28495615/a-novel-function-of-tlr4-in-mediating-the-immunomodulatory-effect-of-benzanthrone-an-environmental-pollutant
#13
Prachi Tewari, Payal Mandal, Ruchi Roy, Somya Asthana, Premendra D Dwivedi, Mukul Das, Anurag Tripathi
Our prior studies have reported that Benzanthrone (BA) manifests inflammatory responses in the spleen of Balb/c mice. The present investigation was carried out to study the impact of BA on macrophages, which are the primary scavenger cells in the body that act as a connecting link between innate and adaptive immunity. Parenteral administration of BA (daily for one week) to mice resulted in enhanced levels of nitric oxide (NO) and overexpression of inflammatory markers (COX-2, MMP-9 and PGE-2) in macrophages; however the level of MHC class-I and MHC class-II receptors were down regulated...
May 8, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28489942/biotunable-nanoplasmonic-filter-on-few-layer-mos2-for-rapid-and-highly-sensitive-cytokine-optoelectronic-immunosensing
#14
Younggeun Park, Byunghoon Ryu, Bo-Ram Oh, Yujing Song, Xiaogan Liang, Katsuo Kurabayashi
Monitoring of the time-varying immune status of a diseased host often requires rapid and sensitive detection of cytokines. Metallic nanoparticle-based localized surface plasmon resonance (LSPR) biosensors hold promise to meet this clinical need by permitting label-free detection of target biomolecules. These biosensors, however, continue to suffer from relatively low sensitivity as compared to conventional immunoassay methods that involve labeling processes. Their response speeds also need to be further improved to enable rapid cytokine quantification for critical care in a timely manner...
May 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28488441/multiscale-studies-on-ionic-liquids
#15
Kun Dong, Xiaomin Liu, Haifeng Dong, Xiangping Zhang, Suojiang Zhang
Ionic liquids (ILs) offer a wide range of promising applications because of their much enhanced properties. However, further development of such materials depends on the fundamental understanding of their hierarchical structures and behaviors, which requires multiscale strategies to provide coupling among various length scales. In this review, we first introduce the structures and properties of these typical ILs. Then, we introduce the multiscale modeling methods that have been applied to the ILs, covering from molecular scale (QM/MM), to mesoscale (CG, DPD), to macroscale (CFD for unit scale and thermodynamics COSMO-RS model and environmental assessment GD method for process scale)...
May 10, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28484078/androgen-signaling-negatively-controls-group-2-innate-lymphoid-cells
#16
Sophie Laffont, Eve Blanquart, Magali Savignac, Claire Cénac, Gilles Laverny, Daniel Metzger, Jean-Philippe Girard, Gabrielle T Belz, Lucette Pelletier, Cyril Seillet, Jean-Charles Guéry
Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33-driven lung inflammation, correlating with an impaired expansion of lung ILC2s...
May 8, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28467830/the-environment-as-a-driver-of-immune-and-endocrine-responses-in-dolphins-tursiops-truncatus
#17
Patricia A Fair, Adam M Schaefer, Dorian S Houser, Gregory D Bossart, Tracy A Romano, Cory D Champagne, Jeffrey L Stott, Charles D Rice, Natasha White, John S Reif
Immune and endocrine responses play a critical role in allowing animals to adjust to environmental perturbations. We measured immune and endocrine related markers in multiple samples from individuals from two managed-care care dolphin groups (n = 82 samples from 17 dolphins and single samples collected from two wild dolphin populations: Indian River Lagoon, (IRL) FL (n = 26); and Charleston, (CHS) SC (n = 19). The immune systems of wild dolphins were more upregulated than those of managed-care-dolphins as shown by higher concentrations of IgG and increases in lysozyme, NK cell function, pathogen antibody titers and leukocyte cytokine transcript levels...
2017: PloS One
https://www.readbyqxmd.com/read/28466565/aging-leads-to-impaired-epicutaneous-sensitization-that-causes-attenuated-allergy-and-pulmonary-inflammation-in-mice
#18
Sheila Langier, Shira Benor, Laliv Kadar, Nir Shani, Sara Etkin, Moshe Stark, Ekaterina Bondar, Asaf Aizic, Shmuel Kivity
Aging is associated with altered decreased barrier function in the skin, which can lead to different types of immunoglobulin E (IgE)-mediated sensitization to environmental allergens. Yet, allergen-specific respiratory sensitization among the elderly is not well described. The aim of this study was to investigate the effect of aging on allergic pulmonary inflammation induced by epicutaneous sensitization of mechanically irritated skin in mice. For this purpose, 6-week-, 6-month-, and 18-month-old female BALB/c mice, underwent epicutaneous sensitization with ovalbumin (OVA) or PBS, followed by an inhaled OVA challenge...
May 3, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28459547/ionic-liquids-in-selective-oxidation-catalysts-and-solvents
#19
Chengna Dai, Jie Zhang, Chongpin Huang, Zhigang Lei
Selective oxidation has an important role in environmental and green chemistry (e.g., oxidative desulfurization of fuels and oxidative removal of mercury) as well as chemicals and intermediates chemistry to obtain high-value-added special products (e.g., organic sulfoxides and sulfones, aldehydes, ketones, carboxylic acids, epoxides, esters, and lactones). Due to their unique physical properties such as the nonvolatility, thermal stability, nonexplosion, high polarity, and temperature-dependent miscibility with water, ionic liquids (ILs) have attracted considerable attention as reaction solvents and media for selective oxidations and are considered as green alternatives to volatile organic solvents...
May 1, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28458151/immunosuppressive-effects-and-associated-compensatory-responses-in-zebrafish-after-full-life-cycle-exposure-to-environmentally-relevant-concentrations-of-cadmium
#20
Sai-Nan Guo, Jia-Lang Zheng, Shuang-Shuang Yuan, Qing-Ling Zhu, Chang-Wen Wu
In natural environments, fish survive in polluted water by cadmium (Cd) throughout their whole life cycle. However, little information is available on Cd toxicity considering a life cycle assessment. The present study investigated effects of environmental levels of cadmium (0, 2.5, and 5μg/L) on immune responses in liver and spleen of zebrafish for 15 weeks, from embryos to sexually maturity. Nitric oxide (NO) levels and iNOS activity declined in liver and spleen of zebrafish exposed to 5μg/L Cd, suggesting an immunosuppressive effect...
April 22, 2017: Aquatic Toxicology
keyword
keyword
106769
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"