keyword
MENU ▼
Read by QxMD icon Read
search

Environmental ilnesses

keyword
https://www.readbyqxmd.com/read/28431925/analysis-of-pm2-5-induced-cytotoxicity-in-human-hacat-cells-based-on-a-microfluidic-system
#1
Yuxiao Zhang, Lulu Zheng, Jiang Tuo, Qi Liu, Xinlian Zhang, Zhixuan Xu, Sixiu Liu, Guodong Sui
Human exposure to PM2.5 causes several adverse health effects. Skin is the first barrier against harmful environmental substances and can has direct contact with PM2.5, but there is no study about PM2.5-induced cytotoxicity in human skin cells on the molecular level partially due to the shortcomings of traditional research methods. In present study, we established a microfluidic system including a cell culture chip integrated with a high-throughput protein microarray chip to investigate the mechanism of PM2...
April 18, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28431520/infectious-agents-is-a-risk-factor-for-myxomatous-mitral-valve-degeneration-a-case-control-study
#2
Marcos Gradim Tiveron, Pablo Maria Alberto Pomerantzeff, Maria de Lourdes Higuchi, Marcia Martins Reis, Jaqueline de Jesus Pereira, Joyce Tieko Kawakami, Renata Nishiyama Ikegami, Carlos Manuel de Almeida Brandao, Fabio Biscegli Jatene
BACKGROUND: The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze the effect of Mycoplasma pneumoniae (Mp), Chlamydophila pneumoniae (Cp) and Borrelia burgdorferi (Bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve degeneration etiopathogenesis...
April 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28427412/lack-of-interleukin-13-receptor-%C3%AE-1-delays-the-loss-of-dopaminergic-neurons-during-chronic-stress
#3
Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher, Bruno Conti
BACKGROUND: The majority of Parkinson's disease (PD) cases are sporadic and idiopathic suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors. Stress and neuroinflammation are among the factors being investigated for their possible contributions to PD. Experiments in rodents showed that severe chronic stress can reduce the number of dopaminergic neurons in the substantia nigra pars compacta (SNc); the same cells that are lost in PD. These actions are at least in part mediated by increased oxidative stress...
April 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28412141/toll-like-receptor-4-activation-can-be-either-detrimental-or-beneficial-following-mild-repetitive-traumatic-brain-injury-depending-on-timing-of-activation
#4
Frances Corrigan, Alina Arulsamy, Lyndsey E Collins-Praino, Joshua L Holmes, Robert Vink
A history of repeated concussion has been linked to the later development of neurodegeneration, which is associated with the accumulation of hyperphosphorylated tau and the development of behavioral deficits. However, the role that exogenous factors, such as immune activation, may play in the development of neurodegeneration following repeated mild traumatic brain injury (rmTBI) has not yet been explored. To investigate, male Sprague-Dawley rats were administered three mTBIs 5 days apart using the diffuse impact-acceleration model to generate ∼100G...
April 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28406619/interaction-between-dissolved-organic-matter-and-long-chain-ionic-liquids-a-microstructural-and-spectroscopic-correlation-study
#5
Xiao-Yang Liu, Wei Chen, Chen Qian, Han-Qing Yu
The production and use of ionic liquids (ILs) increase the potential risk after their emission into the environment. After entering the environment, ILs will readily interact with dissolved organic matter (DOM), and their environmental behavior will be impacted by DOM, which is abundant in the environment and has various functional groups. However, to date, the interaction between DOM and ILs, especially long-chain ILs, remains unclear. In this work, the interaction between long-chain ILs and humic acid (HA), a representative DOM, was investigated using synchronous fluorescence, Fourier transform infrared spectroscopy, dynamic light scattering and zeta potential techniques, which were integrated with two-dimensional correlation spectroscopy (2DCOS), hetero-2DCOS and perturbation-correlation moving-window analyses...
April 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28405903/stress-induced-alterations-of-immune-profile-in-animals-suffering-by-tau-protein-driven-neurodegeneration
#6
Petr Novak, Martin Cente, Nina Kosikova, Tomas Augustin, Richard Kvetnansky, Michal Novak, Peter Filipcik
Alzheimer's disease (AD) is a multifactorial disorder; neurofibrillary pathology composed of tau protein is found side by side with amyloid-β deposits and extensive neuroinflammation. The immune system of the brain is considered as one of the factors that could influence the speed of the progression of AD neuropathology as a potential mediator of the damage induced by AD protein deposits. Alzheimer's disease pathology can be impacted by psychological stress; however, signalling pathways in background are not well known...
April 12, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28399486/determination-of-cytokine-levels-in-multiple-sclerosis-patients-and-their-relevance-with-patients-response-to-cinnovex
#7
Mohammad Taheri, Soudeh Ghafouri-Fard, Ghasem Solgi, Arezou Sayad, Mehrdokht Mazdeh, Mir Davood Omrani
Multiple sclerosis (MS) is a heterogeneous chronic immune-mediated disorder of the central nervous system (CNS) with several environmental and genetic factors participating in its development and disease course. Interferon (IFN)-β therapy is considered as the first line treatment in this disorder. The present study enrolled 231 relapsing-remitting MS patients who were diagnosed as IFN-β responders (n=146) and non-responders (n=85). Serum cytokine levels were analyzed by commercially available ELISA kits in distinct groups based on HLA-A, -B and -DRB1 alleles...
April 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28399471/cigarette-smoke-extract-cse-induces-rage-mediated-inflammation-in-the-ca9-22-gingival-carcinoma-epithelial-cell-line
#8
Nolan T Sanders, Derek J Dutson, Justin W Durrant, Joshua B Lewis, Shalene H Wilcox, Duane R Winden, Juan A Arroyo, Benjamin T Bikman, Paul R Reynolds
OBJECTIVE: The oral environment is anatomically positioned as a significant gateway for exposure to environmental toxicants. Cigarette smoke exposure compromises oral health by orchestrating inflammation. The receptor for advanced glycation end-products (RAGE) has been implicated in smoke-induced inflammatory effects; however, its role in the oral cavity is unknown. The purpose of this study was to determine RAGE expression by immortalized gingival carcinoma cells and the degree to which RAGE-mediated signaling influences inflammation...
March 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28390669/analysis-of-phenolic-acids-by-ionic-liquid-in-water-microemulsion-liquid-chromatography-coupled-with-ultraviolet-and-electrochemical-detector
#9
Li-Qing Peng, Jun Cao, Li-Jing Du, Qi-Dong Zhang, Yu-Tin Shi, Jing-Jing Xu
An environmentally friendly ionic liquid-in-water (IL/W) microemulsion was established and applied as mobile phase in microemulsion liquid chromatography (MELC) with ultraviolet (UV) detection or electrochemical detector (ECD) for analysis of phenolic compounds in real samples. The optimal condition of the method was using the best composition of microemulsion (0.2% w/v [HMIM]PF6, 1.0% w/v SDS, 3.0% w/v n-butanol, 95.8% v/v water, pH 2.5) with UV detection. The validation results indicated that the method provided high degree of sensitivity, precision and accuracy with the low limit of detections ranged from 17...
April 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28388893/genome-wide-identification-and-expression-analysis-of-cllax-clpin-and-clabcb-genes-families-in-citrullus-lanatus-under-various-abiotic-stresses-and-grafting
#10
Chenliang Yu, Wenqi Dong, Yihua Zhan, Zong-An Huang, Zhimiao Li, Il Seop Kim, Chenghao Zhang
BACKGROUND: Auxin plays an important role in regulating plant growth and development as well as in the response of plants to abiotic stresses. Auxin is transported by three kinds of major protein families, including the AUXIN RESISTANT 1/LIKE AUX1 (AUX⁄LAX) influx carriers, the PIN-FORMED (PIN) efflux carriers and the ATP binding cassette B/P-glycoprotein/Multidrug-resistance (ABCB/MDR/PGP) efflux/condition carriers. The biological function of several auxin transporter genes has been well characterized in Arabidopsis thaliana...
April 7, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28382039/genetic-and-epigenetic-determinants-in-autoinflammatory-diseases
#11
REVIEW
Damiana Álvarez-Errico, Roser Vento-Tormo, Esteban Ballestar
The concept of autoinflammation has evolved over the past 20 years, beginning with the discovery that mutations in the Mediterranean Fever (MEFV) gene were causative of Familial Mediterranean Fever. Currently, autoinflammatory diseases comprise a wide range of disorders with the common features of recurrent fever attacks, prevalence of hyperreactive innate immune cells, and signs of inflammation that can be systemic or organ specific in the absence of pathogenic infection of autoimmunity. Innate immune cells from the myeloid compartment are the main effectors of uncontrolled inflammation that is caused in great extent by the overproduction of inflammatory cytokines such as IL-1β and IL-18...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28380011/increased-inflammation-is-associated-with-islet-autoimmunity-and-type-1-diabetes-in-the-diabetes-autoimmunity-study-in-the-young-daisy
#12
Kathleen Waugh, Janet Snell-Bergeon, Aaron Michels, Fran Dong, Andrea K Steck, Brigitte I Frohnert, Jill M Norris, Marian Rewers
BACKGROUND: Type 1 diabetes (TID) is characterized by a loss of pancreatic islet beta cell function resulting in loss of insulin production. Genetic and environmental factors may trigger immune responses targeting beta cells thus generating islet antibodies (IA). Immune response pathways involve a cascade of events, initiated by cytokines and chemokines, producing inflammation which can result in tissue damage. METHODS: A nested case-control study was performed to identify temporal changes in cytokine levels in 75 DAISY subjects: 25 diagnosed T1D, 25 persistent IA, and 25 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28379573/the-effect-of-chronic-ammonia-exposure-on-acute-phase-proteins-immunoglobulin-and-cytokines-in-laying-hens
#13
Y N Wu, F F Yan, J Y Hu, H Chen, C M Tucker, A R Green, H W Cheng
Ammonia ( ) is a potential health hazard to both humans and animals, causing local and systemic low-grade inflammation based on its levels and exposure durations. The objective of this study was to examine the effects of 45 wk of exposure to 30 ppm NH 3 on the concentrations of acute-phase proteins, immunoglobulins, and cytokines in laying hens. At 18 wk of age, a group of Hy-Line W-36 hens was randomly assigned to 4-hen cages. These cages were evenly divided between 2 environmentally controlled chambers. At 25 wk of age, one chamber was maintained continuously with fresh air (NH 3 < 5 ppm; control group) and the other one was injected with NH 3 and controlled at 30 ppm (NH 3 group) for 45 wk...
March 31, 2017: Poultry Science
https://www.readbyqxmd.com/read/28376678/whole-body-precooling-attenuates-the-extracellular-hsp72-il-6-and-il-10-responses-after-an-acute-bout-of-running-in-the-heat
#14
Ben J Lee, Neil D Clarke, Joanne Hankey, Charles D Thake
The impact of whole-body precooling on the extracellular heat shock protein 72 (eHSP72) and cytokine responses to running in the heat is undefined. The aim of this study was to determine whether precooling would attenuate post-exercise eHSP72 and cytokine responses. Eight male recreational runners completed two 90-minute bouts of running at 65% [Formula: see text]O2max in 32 ± 0.9°C and 47 ± 6 % relative humidity (RH) preceded by either 60-minutes of precooling in 20.3 ± 0.3°C water (COOL) or 60 min rest in an air-conditioned laboratory (20...
April 5, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28376397/a-smartphone-imaging-based-label-free-and-dual-wavelength-fluorescent-biosensor-with-high-sensitivity-and-accuracy
#15
Won-Il Lee, Sajal Shrivastava, Le-Thai Duy, Bo Yeong Kim, Young-Min Son, Nae-Eung Lee
The accuracy of a bioassay based on smartphone-integrated fluorescent biosensors has been limited due to the occurrence of false signals from non-specific reactions as well as a high background and low signal-to-noise ratios for complementary metal oxide semiconductor image sensors. To overcome this problem, we demonstrate dual-wavelength fluorescent detection of biomolecules with high accuracy. Fluorescent intensity can be quantified using dual wavelengths simultaneously, where one decreases and the other increases, as the target analytes bind to the split capture and detection aptamer probes...
March 30, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28375932/outstanding-animal-studies-in-allergy-ii-from-atopic-barrier-and-microbiome-to-allergen-specific-immunotherapy
#16
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal studies published within the past 18 months were assessed, focusing on innate and specific immunomodulation, providing knowledge of high translational relevance for human atopic and allergic diseases. RECENT FINDINGS: Allergic companion animals represent alternative models, but most studies were done in mice. Atopic dermatitis mouse models were refined by the utilization of cytokines like IL-23 and relevant skin allergens or enzymes. A novel IL-6 reporter mouse allows biomonitoring of inflammation...
April 1, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28366041/a-single-dose-of-trichloroethylene-given-during-development-does-not-substantially-alter-markers-of-neuroinflammation-in-brains-of-adult-mice
#17
Jacqueline R Meadows, Chevonne Parker, Kathleen M Gilbert, Sarah J Blossom, Jamie C DeWitt
Trichloroethylene (TCE) is a widespread environmental contaminant associated with developmental immunotoxicity and neurotoxicity. Previous studies have shown that MRL(+/+) mice exposed to TCE from gestation through early-life demonstrate robust increases in inflammatory markers in peripheral CD4(+) T-cells, as well as glutathione depletion and increased oxidative stress in cerebellum-associated with alterations in behavior. Since increased oxidative stress is associated with neuroinflammation, we hypothesized that neuroinflammatory markers could be altered relative to unexposed mice...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28362692/breast-milk-tgf%C3%AE-is-associated-with-neonatal-gut-microbial-composition
#18
Alexandra R Sitarik, Kevin R Bobbitt, Suzanne L Havstad, Kei E Fujimura, Albert M Levin, Edward M Zoratti, Haejin Kim, Kimberley J Woodcroft, Ganesa Wegienka, Dennis R Ownby, Christine L M Joseph, Susan V Lynch, Christine C Johnson
OBJECTIVES: Breast milk is a complex bioactive fluid that varies across numerous maternal and environmental conditions. While breastfeeding is known to impact neonatal gut microbiome, the milk components responsible for this effect are not well-characterized. Given the wide range of immunological activity breast milk cytokines engage in, we investigated three essential breast milk cytokines and their association with early life gut microbiota. METHODS: A total of 52 maternal-child pairs were drawn from a racially diverse birth cohort based in Detroit, Michigan...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28361334/chronic-recurrent-multifocal-osteomyelitis-and-related-diseases-update-on-pathogenesis
#19
REVIEW
Allison J Cox, Yongdong Zhao, Polly J Ferguson
PURPOSE OF REVIEW: We focus on recent advances in the understanding of the genetic, molecular, immunologic, and environmental factors implicated in the pathogenesis of autoinflammatory bone diseases including the syndromic and non-syndromic forms of chronic recurrent multifocal osteomyelitis (CRMO). RECENT FINDINGS: Evidence implicating the IL-1 pathway in the pathogenesis of the Mendelian forms of CRMO is growing. LIPIN2 can regulate the NLRP3 inflammasome by affecting P2X7 receptor activation, and intracellular cholesterol can modulate P2X7R currents...
April 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28359987/developmental-options-and-functional-plasticity-of-innate-lymphoid-cells
#20
REVIEW
Ai Ing Lim, Thomas Verrier, Christian Aj Vosshenrich, James P Di Santo
Innate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lymphocytes including natural killer (NK) cells and at least three distinguishable cell subsets (ILC1, ILC2, ILC3) that rapidly produce cytokines (IFN-γ, IL-5, IL-13, IL-17A, IL-22) upon activation. As such, ILCs can act as first-line defenders in the context of infection, inflammation and cancer. Because of the strong conservation between the expression of key transcription factors that can drive signature cytokine outputs in ILCs and differentiated helper T cells, it has been proposed that ILCs represent innate counterparts of the latter...
March 27, 2017: Current Opinion in Immunology
keyword
keyword
106769
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"