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Environmental ilnesses

Javad Safaei Ghomi, Safura Zahedi
A family of novel ionic liquid with l-alanine and choline chloride as environmentally benign materials have been synthesized and grafted on Fe3O4 nanoparticles using easy preparation techniques. The structure of ionic liquid supported on Fe3O4 nanoparticles (IL-Fe3O4 NPs) characterized by various analyses such as FE-SEM, EDX, XRD, NMR, FTIR and VSM. The catalytic activities of this catalyst are examined in the Mannich reaction for synthesis of β-aminocarbonyl compounds under ultrasonic irradiation. The recyclability of catalyst is investigated, and the results have indicated that the catalyst can be recycled six times without obvious activity decreasing...
January 2017: Ultrasonics Sonochemistry
Eun-Young Nam, Sun Ah Kim, Heejung Kim, Su-Hyun Kim, Jae-Hyun Han, Ju-Hee Lee, Dong-Il Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Evodiae Fructus (EF) is the dried, unripe fruit of Evodia rutaecarpa Benth., and one of the main components of traditional herbal prescriptions issued for the treatment of sterility caused by irregular menstruation in Korea. However, scientific evidence regarding the efficacy and action mechanism of EF is lacking. AIM OF THE STUDY: In this study, the authors established an in vitro screening tool to identify promising new drug candidates in herbal medicines for the prevention and treatment of premature ovarian failure...
October 18, 2016: Journal of Ethnopharmacology
Zhong-Kai Lu, Zhi-Rong Chen, Jun-Yi Zhu, Ya Xu, Xian Hua
Inflammatory bowel disease (IBD) is a chronic, complex genetic disease with rapidly increasing prevalence in China. The interactions of genetic, environmental, and microbial factors contribute to the development of IBD, however, the precise etiologies of IBD are not well understood yet. Interleukin-23 receptor (IL-23R) encodes a subunit of receptor for IL-23, which is an important proinflammatory cytokine. In this study, we investigated the relationship between the single nucleotide polymorphism (SNP) of IL-23R gene and IBD in Chinese Han population...
September 27, 2016: Oncotarget
T B Opstad, B S Brusletto, H Arnesen, A Å Pettersen, I Seljeflot
RATIONALE: The heterodimer IL-12 is an inducer of Th1 responses and stimulates INFƴ production. Micro-RNA-21 (miR-21) is described as a key regulator of the pro-inflammatory response and has IL-12p35 mRNA as one of its main targets. The IL-12p40 1188A/C genetic variant located in 3'untranslated region (UTR), thus environmentally exposed, has further been reported to modify IL-12 levels. We have previously reported on the lowering effect of cigarette smoke on circulating IL-12 in patients with coronary artery disease (CAD)...
October 13, 2016: Immunobiology
Vitthal B Saptal, Bhalchandra M Bhanage
A series of highly efficient, bifunctional ionic liquids containing a quaternary alkyl ammonium cation and an amine anion were prepared from choline and amino acids, respectively. Nine ILs were synthesized, characterized, and applied as organocatalysts for the chemical fixation of carbon dioxide to form cyclic carbonates and quinazoline-2,4(1 H,3 H)-diones. A binary mixture of an IL and a co-catalysts generates deep eutectic solvents (DESs) and accelerates the rate of the cycloaddition reaction at atmospheric pressure and low temperature (70 °C)...
October 20, 2016: ChemSusChem
Joshua B Lewis, Dallin C Milner, Adam L Lewis, Todd M Dunaway, Kaleb M Egbert, Scott C Albright, Brigham J Merrell, Troy D Monson, Dallin S Broberg, Jason R Gassman, Daniel B Thomas, Juan A Arroyo, Paul R Reynolds
It has long been understood that increased epithelial permeability contributes to inflammation observed in many respiratory diseases. Recently, evidence has revealed that environmental exposure to noxious material such as cigarette smoke reduces tight junction barrier integrity, thus enhancing inflammatory conditions. Claudin-6 (Cldn6) is a tetraspanin transmembrane protein found within the tight junctional complex and is implicated in maintaining lung epithelial barriers. To test the hypothesis that increased Cldn6 ameliorates inflammation at the respiratory barrier, we utilized the Tet-On inducible transgenic system to conditionally over-express Clnd6 in the distal lung...
October 17, 2016: International Journal of Environmental Research and Public Health
Cassandra E Deering-Rice, Chris Stockmann, Erin G Romero, Zhenyu Lu, Darien Shapiro, Brian L Stone, Bernhard Fassl, Flory Nkoy, Derek A Uchida, Robert M Ward, John M Veranth, Christopher A Reilly
Transient receptor potential (TRP) channels are activated by environmental particulate materials. We hypothesized that polymorphic variants of TRPV1 would be uniquely responsive to insoluble coal fly ash compared to the prototypical soluble agonist capsaicin. Furthermore, these changes would manifest as differences in lung cell responses to these agonists and perhaps correlate with changes in asthma symptom control. The TRPV1 I315M and T469I variants were more responsive to capsaicin and coal fly ash. The I585V variant was less responsive to coal fly ash particles, due to reduced translation of protein and an apparent role for I585 in activation by particles...
October 7, 2016: Journal of Biological Chemistry
Lorenza Rattazzi, Giuseppa Piras, Samuel Brod, Koval Smith, Masahiro Ono, Fulvio D'Acquisto
T cells are known to be plastic and to change their phenotype according to the cellular and biochemical milieu they are embedded in. In this study, we transposed this concept at a macroscopic level assessing whether changes in the environmental housing conditions of C57/BL6 mice would influence the phenotype and function of T cells. Our study shows that exposure to 2 weeks in an enriched environment (EE) does not impact the T cell repertoire in vivo and causes no changes in the early TCR-driven activation events of these cells...
2016: Frontiers in Immunology
Paul C Schröder, Sabina Illi, Vera I Casaca, Anna Lluis, Andreas Böck, Caroline Roduit, Martin Depner, Remo Frei, Jon Genuneit, Petra Ina Pfefferle, Marjut Roponen, Juliane Weber, Charlotte Braun-Fahrländer, Josef Riedler, Jean-Charles Dalphin, Juha Pekkanen, Roger Lauener, Erika von Mutius, Bianca Schaub, Anne Hyvärinen, Anne M Karvonen, Maija-Riitta Hirvonen, Pekka Tiittanen, Sami Remes, Vincent Kaulek, Marie-Laure Dalphin, Markus J Ege, Georg J Loss, Harald Renz, Gert Doekes, Michael Kabesch
BACKGROUND: Farm exposure protects against development of allergies early in life. At 4.5 years, protection against asthma by farm-milk exposure was partially mediated by regulatory T-cells (Tregs). The aim of this study was to investigate the critical time window of the "asthma-protective" farm effect via Tregs during childhood immune maturation. METHODS: Tregs were assessed longitudinally at 4.5 and 6 years in 111 children (56 farm, 55 reference children) from the PASTURE/EFRAIM birth cohort (flow-cytometry)...
October 12, 2016: Allergy
Denise S M Medrado da Costa, Joana Hygino, Thais B Ferreira, Taissa M Kasahara, Priscila O Barros, Clarice Monteiro, Aleida Oliveira, Felipe Tavares, Claudia Cristina Vasconcelos, Regina Alvarenga, Cleonice A M Bento
Vitamin D deficiency is an environmental risk factor for MS, a Th17 cell-mediated autoimmune disease that results in demyelination in the CNS. Therefore, we aimed to evaluate the ability of in vitro 1,25(OH)2D in modulating different Th17 cell subsets in MS patients in remission phase. In the present study, the production of Th17-related cytokines (IL-1β, IL-6, IL-17, IL-22), as well as GM-CSF, was significantly higher in cell cultures from MS patients than in healthy subjects (HS). The 1,25(OH)2D reduced all pro-inflammatory cytokines essayed, mainly those released from HS cell cultures...
October 15, 2016: Journal of Neuroimmunology
Anelise Barth, Natália Brucker, Angela M Moro, Sabrina Nascimento, Gabriela Goethel, Caroline Souto, Rafael Fracasso, Elisa Sauer, Louise Altknecht, Bárbara da Costa, Marta Duarte, Camila B Menezes, Tiana Tasca, Marcelo D Arbo, Solange Cristina Garcia
Environmental exposure to pollutants, especially polycyclic aromatic hydrocarbons (PAHs), could lead to carcinogenesis development. However, there is a gap on the mechanisms involved in this effect. Therefore, the aim of this study was to investigate the potential relationship between exposure to environmental air pollution and inflammation process in DNA damage in taxi drivers. This study included 45 taxi drivers and 40 controls; non-smokers composed both groups. Biological monitoring was performed through quantification of urinary 1-hydroxypyrene (1-OHP)...
October 8, 2016: Environmental Science and Pollution Research International
Şükrü Kartalcı, Lale Gönenir Erbay, Esra Porgalı Zayman, Önder Otlu, Aysun Bay Karabulut, Gülşen Kartalcı
OBJECTIVE: Schizophrenia is a chronic psychotic disorder in which genetics and environmental factors such as infection and the corresponding immune response play a role in the etiopathogenesis. The aim of this study was to compare some immune factors such as nuclear factor-B (NF-B) activation, myeloperoxidase (MPO), the anti-inflammatory cytokine interleukin-4 (IL-4), and regulatory cytokine transforming growth factor- (TGF-) in schizophrenia patients and an age- and gender-matched control group...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
Bingjie Wang, Brian J McHugh, Ayub Qureshi, Dominic J Campopiano, David J Clarke, J Ross Fitzgerald, Julia R Dorin, Richard Weller, Donald J Davidson
Atopic Dermatitis (AD) is a common chronic inflammatory skin disease, resulting in significant morbidity. A hallmark of AD is disruption of the critical barrier function of upper epidermal layers, causatively linked to environmental stimuli, genetics and infection, and a critical current target for the development of new therapeutic and prophylactic interventions. S. aureus is an AD-associated pathogen producing virulence factors which induce skin barrier disruption in vivo and contribute to AD pathogenesis...
September 9, 2016: Journal of Investigative Dermatology
Gaurav Shrivastava, Moisés León-Juárez, Julio García-Cordero, David Eduardo Meza-Sánchez, Leticia Cedillo-Barrón
A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed inflammasomes, which induce downstream immune responses to specific pathogens, environmental stimuli, and host cell damage. Inflammasomes are composed of cytoplasmic sensor molecules such as NLRP3 or absent in melanoma 2 (AIM2), the adaptor protein ASC (apoptosis-associated speck-like protein containing caspase recruitment domain), and the effector protein procaspase-1...
October 3, 2016: Immunologic Research
Hiroko Inoue, Atsuhiro Kishimoto, Ryoko Ushikoshi-Nakayama, Ayaka Hasaka, Ayako Takahashi, Koufuchi Ryo, Takashi Muramatsu, Fumio Ide, Kenji Mishima, Ichiro Saito
Resveratrol is a natural polyphenol produced by plants in response to environmental stress. This compound has been shown to have pharmacological effects against a wide range of diseases including neurological, hepatic, cardiovascular and autoimmune conditions. The non-obese diabetic (NOD) mouse, in which loss of lacrimal and salivary gland function occurs, has been studied as an animal model for Sjögren's syndrome. In this study, we confirmed that administration of resveratrol results in increased secretion of saliva in NOD mice...
September 2016: Journal of Clinical Biochemistry and Nutrition
Zhenzhen Liu, Zhengwei Fu, Yuanxiang Jin
Atrazine (ATZ) and its main metabolites, i.e., diaminochlorotriazine (DACT), deisopropylatrazine (DIP), and deethylatrazine (DE), have been widely detected in surface water around the world. In the present study, to determine their immunotoxic effects, zebrafish during the early developmental stage were exposed to ATZ and its main metabolites at environmental concentrations (30, 100, 300 μg L(-1)). It was observed that ATZ, DACT, DIP and DE selectively induced the transcription of immunotoxic related genes including Tnfα, Il-1β, Il-6, Il-8, Cxcl-clc and Cc-chem in larval zebrafish...
January 2017: Chemosphere
Virginie Deswaerte, Saleela M Ruwanpura, Brendan J Jenkins
Over the last decade it has emerged that inflammasome complexes provide a pivotal platform for the host innate immune system to respond to exogenous infectious microbes (viruses, bacteria, fungi) and non-infectious environmental agents (cigarette smoke, pollution), as well as endogenous "danger" signals. Upon the canonical activation of inflammasomes, a key effector function is to catalyze, via caspase-1, the maturation of the potent pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which, in addition to chronic inflammatory responses have also been intimately linked to the inflammatory form of lytic cell death, pyroptosis...
September 30, 2016: Molecular Immunology
Herbert Ssegane, M Cristina Negri
Locating bioenergy crops on strategically selected subfield areas of marginal interest for commodity agriculture can increase environmental sustainability. Location and choice of bioenergy crops should improve environmental benefits with minimal disruption of current food production systems. We identified subfield soils of a tile-drained agricultural watershed as marginal if they had areas of low crop productivity index (CPI), were susceptible to nitrate-nitrogen (NO-N) leaching, or were susceptible to at least two other forms of environmental degradation (marginal areas)...
September 2016: Journal of Environmental Quality
Shimeng Luo, Yun Li, Yingpei Li, Qixing Zhu, Jianhua Jiang, Changhao Wu, Tong Shen
Increasing evidence demonstrates that perinatal exposure to Bisphenol A (BPA) can cause immune disorders throughout the life span. However, the biological basis for these immune disorders is poorly understood and the effects of exposure to BPA on Th17 development are unknown. The present study sought to characterize alterations of Th17 cells in childhood and adulthood following gestational and lactational exposure to environmentally relevant low-dose of BPA and the underlying mechanisms. Pregnant dams were exposed to BPA (10, 100 or 1000nM) via drinking water from gestational day (GD) 0 to postnatal day (PND) 21...
September 26, 2016: Environmental Toxicology and Pharmacology
Sanja Stopinšek, Alojz Ihan, Barbara Salobir, Marjeta Terčelj, Saša Simčič
BACKGROUND: Composition of organic dust is very complex, involving particles of microbial, animal and plant origin. Several environmental exposure studies associate microbial cell wall agents in organic dust with various respiratory symptoms and diseases. The aim of the present study was to investigate the in vitro effects of the co-exposure of fungal cell wall agents (FCWAs) and bacterial lipopolysaccharide (LPS) on inflammatory immune responses of peripheral blood mononuclear cells (PBMCs) from patients with pulmonary sarcoidosis...
2016: Journal of Occupational Medicine and Toxicology
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