Yingduan Cheng, Pei Liang, Hua Geng, Zhaohui Wang, Lili Li, Suk Hang Cheng, Jianming Ying, Xianwei Su, Ka Man Ng, Margaret H L Ng, Tony S K Mok, Anthony T C Chan, Qian Tao
Epigenetic disruption of tumor suppressor genes is frequently involved in tumorigenesis. We identified a novel 19q13 KRAB domain-containing zinc finger protein, ZNF545/ZFP82, broadly expressed in normal tissues but downregulated in multiple tumor cell lines. The ZNF545 promoter contains a CpG island, which is frequently methylated in cell lines. The transcriptional silencing of ZNF545 could be reversed by pharmacologic or genetic demethylation, indicating direct epigenetic silencing. ZNF545 was also frequently methylated in multiple primary tumors of nasopharyngeal, esophageal, lung, gastric, colon, and breast, but rarely in normal epithelial tissues and paired normal tissues...
July 2012: Molecular Cancer Research: MCR