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Management of chronic pain

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https://www.readbyqxmd.com/read/29667130/beneficial-effects-of-the-calcium-channel-blocker-ctk-01512-2-in-a-mouse-model-of-multiple-sclerosis
#1
Rodrigo B M Silva, Samuel Greggio, Gianina T Venturin, Jaderson C da Costa, Marcus V Gomez, Maria M Campos
Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of this molecule in the mouse model of experimental autoimmune encephalomyelitis (EAE). The effects of CTK 01512-2 were compared to those displayed by ziconotide-a selective N-type VGCC blocker clinically used for chronic pain-and fingolimod-a drug employed for MS treatment...
April 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29666030/resection-arthroplasty-compared-with-total-hip-arthroplasty-in-treating-chronic-hip-pain-of-patients-with-a-history-of-substance-abuse
#2
William Curtis, Meir Marmor
BACKGROUND: Retrospective comparison of surgical management of severe hip pain in patients with a history of substance abuse treated by modified Girdlestone resection arthroplasty (RA) vs delayed total hip arthroplasty (THA) following yearlong sobriety pathway. METHODS: Patients were identified using charts, current procedural terminology (CPT) code query, and THA sobriety pathway registry. The primary outcome was adequate pain control following surgery, defined as visual analog scale ≤ 5 or verbal description of "moderate" or lower pain...
March 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29665830/implementation-of-telemedicine-for-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#3
Zhengping Huang, Xia Pan, Weiming Deng, Zhixiang Huang, Yukai Huang, Xuechan Huang, Zhaohua Zhu, Weiyu Han, Shaoling Zheng, Xin Guo, Changhai Ding, Tianwang Li
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies have revealed that patients with OA benefitted from enhanced management via telemedicine. Guangdong Online Hospital (GOH) is the first officially recognized web-based hospital that provides telemedicine service in China...
April 17, 2018: Trials
https://www.readbyqxmd.com/read/29664187/exercise-interventions-and-patient-beliefs-for-people-with-hip-knee-or-hip-and-knee-osteoarthritis-a-mixed-methods-review
#4
REVIEW
Michael Hurley, Kelly Dickson, Rachel Hallett, Robert Grant, Hanan Hauari, Nicola Walsh, Claire Stansfield, Sandy Oliver
BACKGROUND: Chronic peripheral joint pain due to osteoarthritis (OA) is extremely prevalent and a major cause of physical dysfunction and psychosocial distress. Exercise is recommended to reduce joint pain and improve physical function, but the effect of exercise on psychosocial function (health beliefs, depression, anxiety and quality of life) in this population is unknown. OBJECTIVES: To improve our understanding of the complex inter-relationship between pain, psychosocial effects, physical function and exercise...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29663083/-self-hypnosis-training-for-in-hospital-chronic-pain-patients-a-retrolective-observational-study
#5
Peter C Keil, Nicole Lindenberg, Christoph L Lassen, Bernhard M Graf, Jens Meier, Christoph H Wiese
BACKGROUND: Hypnosis is probably one of the oldest therapies known to man. In the last decades modern hypnosis has mainly been used by psychotherapists; however, hypnosis is becoming increasingly more important as a therapeutic method in medicine. Hypnosis can be used for a variety of medical indications. In the literature there is much evidence for the effectiveness of hypnosis. The aim of the present investigation was to demonstrate the effectiveness of hypnosis in inpatient treatment of chronic pain patients and to present a self-hypnosis program, which can be easily integrated into pain therapy...
April 16, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29662720/role-of-active-versus-passive-complementary-and-integrative-health-approaches-in-pain-management
#6
David Cosio, Erica Lin
Background: A general conclusion about the treatment of chronic, noncancer pain is that the results from traditional, passive modalities are disheartening. Perhaps this may be due to the propensity of patients to seek out passive versus active treatments. In pain management, active treatments should be the primary focus, with passive interventions as an adjunct. Objective: The current study tested the hypotheses that Veterans would report a greater significant increase in active versus transitional and active versus passive complementary and integrative health (CIH) utilization after completing a formal pain education program...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29662656/stereotactic-body-radiation-therapy-for-palliative-management-of-pancreatic-adenocarcinoma-in-elderly-and-medically-inoperable-patients
#7
John F Ryan, Lauren M Rosati, Vincent P Groot, Dung T Le, Lei Zheng, Daniel A Laheru, Eun J Shin, Juan Jackson, Joseph Moore, Amol K Narang, Joseph M Herman
Stereotactic body radiation therapy (SBRT) represents a promising treatment option for patients with localized pancreatic ductal adenocarcinoma (PDAC) who cannot tolerate surgical therapy. We retrospectively reviewed the records of patients with localized PDAC treated with SBRT at our institution between 2010 and 2016 to identify patients deemed medically inoperable due to poor performance status, advanced age, and/or comorbid conditions. Overall survival (OS), progression-free survival (PFS), and local progression-free survival (LPFS) were estimated using Kaplan-Meier curves...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661704/becoming-an-ecoach-training-therapists-in-online-cognitive-behavioral-therapy-for-chronic-pain
#8
Jessy A Terpstra, Rosalie van der Vaart, Saskia Spillekom-van Koulil, Arno van Dam, Judith G M Rosmalen, Hans Knoop, Henriët van Middendorp, Andrea W M Evers
OBJECTIVE: Online cognitive-behavioral therapy (iCBT) is effective in supporting patients' self-management. Since iCBT differs from face-to-face CBT on several levels, proper training of therapists is essential. This paper describes the development and evaluation of a therapist training based on theoretical domains that are known to influence implementation behavior, for an iCBT for chronic pain. METHODS: The training consists of 1.5 days and covers the implementation domains "knowledge", "skills", "motivation", and "organization", by focusing on the therapy's rationale, iCBT skills, and implementation strategies...
April 7, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29660743/-rehabilitation-after-multiple-trauma
#9
Stefan Simmel
Many polytrauma patients report significant long-term impairments to their physical and mental health, resulting in a reduction of their quality of life. In addition to the obvious physical accident sequences, psychological influences and the individual context factors pose special challenges to the rehabilitation team and the infrastructure of the facility. Professional reintegration and chronic pain are particularly common problems in the trauma rehabilitation. The central task of rehabilitation after accidents is the restoration or substantial improvement of the functional health and thus the reintegration into the social and professional environment...
April 2018: Die Rehabilitation
https://www.readbyqxmd.com/read/29659375/validity-reliability-feasibility-and-usefulness-of-pain-monitor-a-multidimensional-smartphone-app-for-daily-monitoring-of-adults-with-heterogeneous-chronic-pain
#10
Carlos Suso-Ribera, Diana Castilla, Irene Zaragozá, María Victoria Ribera-Canudas, Cristina Botella, Azucena García-Palacios
OBJECTIVES: Ecological momentary assessment is recommended in the management of chronic pain. Smartphone apps might be a useful tool for that purpose. This study goal was to develop and test a multidimensional smartphone app for adults with chronic pain. A multidisciplinary team developed app content after a series of meetings, considering clinical guidelines for pain measurement. Content included pain intensity and interference, fatigue, mood, perceived health status, activity level, side effects of the medication, use of rescue medication, and pain-related psychological constructs (catastrophizing, acceptance, fear, and coping)...
April 13, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29658795/an-update-and-systematic-review-on-drug-therapies-for-the-treatment-of-refractory-chronic-cough
#11
Nicole M Ryan, Anne E Vertigan, Surinder S Birring
Chronic Cough (CC) is common and often associated with significant comorbidity and decreased quality of life. In up to 50% of cases, the cough is refractory despite extensive investigation and treatment trials. It is likely that the key abnormality in refractory CC is dysfunctional, hypersensitive sensory nerves, similar to conditions such as laryngeal hypersensitivity and neuropathic pain. Areas covered: The aim of this systematic review is to assess drug therapies for refractory CC. The authors review the current management of CC and provide discussion of the similarities between neuropathic pain and refractory CC...
April 16, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29657436/upper-extremity-weightlifting-injuries-diagnosis-and-management
#12
REVIEW
Kayvon Golshani, Mark E Cinque, Peter O'Halloran, Kenneth Softness, Laura Keeling, J Ryan Macdonell
Common upper extremity injuries in resistance training athletes include muscle strains, ligament sprains, pectoralis major tendon ruptures, distal biceps tendon ruptures, and chronic shoulder pain and capsulolabral injuries. While each injury is unique in its specific anatomic location and mechanism, each is preventable with proper exercise technique, safety and maintenance of muscle balance. Conservative treatment is the therapeutic modality of choice and these injuries generally resolve with workout modification, appropriate recovery, anti-inflammatory medication, and physical therapy...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29653266/proteome-based-systems-biology-in-chronic-pain
#13
David Gomez-Varela, Allison M Barry, Manuela Schmidt
Chronic pain represents a major medical challenge in the 21st century. Enormous efforts have been invested towards deciphering the complexity of chronic pain from different angles (molecular, physiological, psychosocial, and behavioral) in both preclinical and clinical settings. While progress has been made, our understanding of the underlying mechanisms of chronic pain remains insufficient. Consequently, chronic pain treatment is often inadequate. It lacks efficacy in most patients and is associated with detrimental side effects - a situation which calls for urgent changes in pain research and management...
April 10, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29652778/does-the-use-of-electrotherapies-increase-the-effectiveness-of-neck-stabilization-exercises-for-improving-pain-disability-mood-and-quality-of-life-in-chronic-neck-pain-a-randomized-controlled-single-blind-study
#14
Hilal Yesil, Simin Hepguler, Umit Dundar, Sahel Taravati, Banu Isleten
STUDY DESIGN: This study was a prospective, randomized, controlled study. OBJECTIVE: The aim of this study was to determine if transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) increase the effectiveness of neck stabilization exercises on pain, disability, mood, and quality of life for chronic neck pain (CNP). SUMMARY OF BACKGROUND DATA: Neck pain is one of the three most frequently reported complaints of the musculoskeletal system...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29652682/kratom-an-emerging-drug-of-abuse-a-case-report-of-overdose-and-management-of-withdrawal
#15
Jack Diep, David Tian Chin, Somdatta Gupta, Faraz Syed, Ming Xiong, Jianguo Cheng
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It is legally and readily available via Internet sales and has been identified as an emerging drug of abuse in the United States. Kratom use has been associated with psychosis, seizures, and even death. At lower doses, kratom acts as a stimulant, while at higher doses, it produces analgesia and euphoria. Here, we describe the successful management of kratom overdose and withdrawal in a young man with negative toxicology screens...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29651872/the-effectiveness-of-12-weeks-of-pilates-intervention-on-disability-pain-and-kinesiophobia-in-patients-with-chronic-low-back-pain-a-randomized-controlled-trial
#16
David Cruz-Díaz, Marta Romeu, Carmen Velasco-González, Antonio Martínez-Amat, Fidel Hita-Contreras
OBJECTIVE: To assess the effectiveness of 12 weeks of Pilates practice on disability, pain and kinesiophobia in patients with chronic non-specific low back pain. DESIGN: This is a randomized controlled trial. SETTING: This study was conducted in the university laboratory. SUBJECTS: A total of 64 participants with chronic non-specific low back pain were included. INTERVENTIONS: Participants were randomly allocated to intervention group consisted in Pilates intervention during 12 weeks ( n = 32) or control group who received no treatment ( n = 32)...
April 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29651640/characteristics-of-new-onset-and-chronic-sleep-medication-users-among-older-adults-a-retrospective-study-of-a-us-medigap-plan-population-using-propensity-score-matching
#17
Shirley Musich, Shaohung S Wang, Luke B Slindee, Lynn Saphire, Ellen Wicker
BACKGROUND: Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE: The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors associated with the conversion from new to chronic use. A secondary objective was to investigate the impact of sleep medications on health outcomes of injurious falls and patterns of healthcare utilization and expenditures...
April 12, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29649527/recommendations-for-evaluation-and-management-of-pain-in-patients-with-mucopolysaccharidosis-in-latin-america
#18
J M Politei, G Gordillo-González, N Guelbert, C F M Souza, C M Lourenço, M L Solano, M M Junqueira, T S P C Magalhães, A M Martins
The mucopolysaccharidosis (MPS) constitute a heterogeneous group of rare genetic disorders caused by enzymatic deficiencies that lead to the accumulation of glycosaminoglycans (GAGs). Several types of MPS are described, historically numbered from I to IX. Clinical observations strongly suggest the presence of chronic pain in patients with all types of MPS. There are few data in the literature on the evaluation and management of pain in these patients, a fact which can compromise the quality of life even more...
April 9, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29649033/predictors-of-admission-after-the-implementation-of-an-enhanced-recovery-after-surgery-pathway-for-minimally-invasive-gynecologic-surgery
#19
Dayley S Keil, Lauren D Schiff, Erin T Carey, Janelle K Moulder, Amy M Goetzinger, Seema M Patidar, Lyla M Hance, Lavinia M Kolarczyk, Robert S Isaak, Paula D Strassle, Jay W Schoenherr
BACKGROUND: Enhanced recovery after surgery (ERAS) pathways in gynecologic surgery have been shown to decrease length of stay with no impact on readmission, but no study has assessed predictors of admission in this population. The purpose of this study was to identify predictors of admission after laparoscopic hysterectomy (LH) and robotic-assisted hysterectomy (RAH) performed under an ERAS pathway. METHODS: This is a prospective observational study of women undergoing LH/RAH for benign indications within an ERAS pathway...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29644469/-cognitive-bias-research-and-depression-in-chronic-pain
#20
REVIEW
A C Rusu, J Hülsebusch
Chronic back pain is of enormous health and economic relevance for industrialized countries because a small group of patients with chronic disease is responsible for a large proportion of medical costs. The prevention of chronic disease is therefore a primary goal in the treatment of patients with acute low back pain. Psychological factors are the central risk factors for later chronification. Above all, especially depressive symptoms and occupational distress, as well as various maladaptive forms of pain management are central risk factors...
April 11, 2018: Der Schmerz
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