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ibs leaky gut syndrome

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https://www.readbyqxmd.com/read/28410406/lubiprostone-improves-intestinal-permeability-in-humans-a-novel-therapy-for-the-leaky-gut-a-prospective-randomized-pilot-study-in-healthy-volunteers
#1
RANDOMIZED CONTROLLED TRIAL
Takayuki Kato, Yasushi Honda, Yusuke Kurita, Akito Iwasaki, Takamitsu Sato, Takaomi Kessoku, Shiori Uchiyama, Yuji Ogawa, Hidenori Ohkubo, Takuma Higurashi, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Atsushi Nakajima
BACKGROUND AND AIMS: The barrier function of the small intestinal mucosa prevents the introduction of undesired pathogens into the body. Breakdown of this barrier function increases intestinal permeability. This has been proposed to induce not only gastrointestinal diseases, including inflammatory bowel disease and irritable bowel syndrome, but also various other diseases, including allergies, diabetes mellitus, liver diseases, and collagen diseases, which are associated with this so called "leaky gut syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/28403801/iga-igm-responses-to-gram-negative-bacteria-are-not-associated-with-perinatal-depression-but-with-physio-somatic-symptoms-and-activation-of-the-tryptophan-catabolite-pathway-at-the-end-of-term-and-postnatal-anxiety
#2
Chutima Roomruangwong, Buranee Kanchanatawan, Sunee Sirivichayakul, George Anderson, André F Carvalho, Sebastien Duleu, Michel Geffard, Michael Maes
Evidence has implicated the translocation of commensal Gram-negative bacteria (Gram-B) due to leaky gut in the pathophysiology of depression and physio-somatic symptoms (e.g. fatigue, pain, irritable bowel syndrome, malaise, etc.). In addition, the leaky gut may contribute to immune-inflammatory activation and oxidative stress. This study investigated whether bacterial translocation is associated with perinatal depression and anxiety scores and with prenatal physio-somatic symptoms and immune-inflammatory biomarkers, including the tryptophan catabolite (TRYCAT) pathway...
April 7, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27884012/gut-microbiota-bacterial-translocation-and-interactions-with-diet-pathophysiological-links-between-major-depressive-disorder-and-non-communicable-medical-comorbidities
#3
REVIEW
Anastasiya Slyepchenko, Michael Maes, Felice N Jacka, Cristiano A Köhler, Tatiana Barichello, Roger S McIntyre, Michael Berk, Iria Grande, Jane A Foster, Eduard Vieta, André F Carvalho
BACKGROUND: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM)...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27829577/chronic-early-life-stress-in-rat-pups-alters-basal-corticosterone-intestinal-permeability-and-fecal-microbiota-at-weaning-influence-of-sex
#4
Nabila Moussaoui, Jonathan P Jacobs, Muriel Larauche, Mandy Biraud, Mulugeta Million, Emeran Mayer, Yvette Taché
Background/Aims: Wistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal axis and impaired epithelial barrier at PND10 and a visceral hypersensitivity at adulthood. Little is known about the impact of early life stress on the offspring before adulthood and the influence of sex. We investigated whether male and female rats previously exposed to LNS displays at weaning altered corticosterone, intestinal permeability, and microbiota...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27547167/chronic-rhinosinusitis-and-irritable-bowel-syndrome-a-case-report
#5
Mikhail Kogan, Carlos Cuellar Castillo, Melissa S Barber
INTRODUCTION: Chronic rhinosinusitis (CRS) and irritable bowel syndrome (IBS) can be comorbidities that are difficult to treat. In this patient, an evidence-informed treatment pathway guided by laboratory biomarkers was used to address both conditions. CASE PRESENTATION: A 69-y-old female patient presented with a 50-y history of sinusitis that was worse in the winter, postnasal drip, frequent sore throats, gastrointestinal complaints, headaches, and yeast infections...
June 2016: Integrative Medicine
https://www.readbyqxmd.com/read/25433843/evidence-for-the-existence-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-with-and-without-abdominal-discomfort-irritable-bowel-syndrome
#6
Michael Maes, Jean-Claude Leunis, Michel Geffard, Michael Berk
BACKGROUND: There is evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation. METHODS: This study was carried out to examine gastro-intestinal symptoms in subjects with ME/CFS versus those with chronic fatigue (CF). The two groups were dissected by dichotomizing those fulfilling and not fulfilling Fukuda's critera...
2014: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/25265577/imaging-the-leaky-gut
#7
EDITORIAL
Michael B Wallace, Maria Vazquez-Roque, Christian Bojarski, Jörg-Dieter Schulzke
No abstract text is available yet for this article.
November 2014: Gastroenterology
https://www.readbyqxmd.com/read/22955358/mucosal-permeability-and-immune-activation-as-potential-therapeutic-targets-of-probiotics-in-irritable-bowel-syndrome
#8
Giovanni Barbara, Lisa Zecchi, Raffaella Barbaro, Cesare Cremon, Lara Bellacosa, Marco Marcellini, Roberto De Giorgio, Roberto Corinaldesi, Vincenzo Stanghellini
There is increasingly convincing evidence supporting the participation of the gut microenvironment in the pathophysiology of irritable bowel syndrome (IBS). Studies particularly suggest an interplay between luminal factors (eg, foods and bacteria residing in the intestine), the epithelial barrier, and the mucosal immune system. Decreased expression and structural rearrangement of tight junction proteins in the small bowel and colon leading to increased intestinal permeability have been observed, particularly in postinfectious IBS and in IBS with diarrhea...
October 2012: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/22179430/leaky-gut-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome-and-inactive-ulcerative-colitis
#9
Krisztina Gecse, Richárd Róka, Teréz Séra, András Rosztóczy, Anita Annaházi, Ferenc Izbéki, Ferenc Nagy, Tamás Molnár, Zoltán Szepes, László Pávics, Lionel Bueno, Tibor Wittmann
BACKGROUND/AIMS: Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS. METHODS: IBS patients of the diarrhea-predominant (IBS-D) and of the constipation-predominant subgroup (IBS-C), patients with inactive UC and healthy subjects were enrolled. Gut permeability was evaluated by measuring 24-hour urine excretion of orally administered (51)Cr-EDTA...
2012: Digestion
https://www.readbyqxmd.com/read/21407167/depression-s-multiple-comorbidities-explained-by-neuro-inflammatory-and-oxidative-nitrosative-stress-pathways
#10
REVIEW
Michael Maes, Marta Kubera, Ewa Obuchowiczwa, Lisa Goehler, Joanna Brzeszcz
There is now evidence that depression, as characterized by melancholic symptoms, anxiety, and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell-mediated activation, inflammation and induction of oxidative and nitrosative stress (IO&NS) pathways and of central microglial activation, decreased neurogenesis and increased apoptosis. This review gives an explanation for the multiple "co-morbidities" between depression and a large variety of a) brain disorders related to neurodegeneration, e...
2011: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/20613941/possible-links-between-intestinal-permeability-and-food-processing-a-potential-therapeutic-niche-for-glutamine
#11
REVIEW
Jean Robert Rapin, Nicolas Wiernsperger
Increased intestinal permeability is a likely cause of various pathologies, such as allergies and metabolic or even cardiovascular disturbances. Intestinal permeability is found in many severe clinical situations and in common disorders such as irritable bowel syndrome. In these conditions, substances that are normally unable to cross the epithelial barrier gain access to the systemic circulation. To illustrate the potential harmfulness of leaky gut, we present an argument based on examples linked to protein or lipid glycation induced by modern food processing...
June 2010: Clinics
https://www.readbyqxmd.com/read/15154150/a-brief-evidence-based-review-of-two-gastrointestinal-illnesses-irritable-bowel-and-leaky-gut-syndromes
#12
REVIEW
David Kiefer, Leila Ali-Akbarian
No abstract text is available yet for this article.
May 2004: Alternative Therapies in Health and Medicine
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