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Pax4 agonist

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https://www.readbyqxmd.com/read/18818287/developmental-and-diurnal-dynamics-of-pax4-expression-in-the-mammalian-pineal-gland-nocturnal-down-regulation-is-mediated-by-adrenergic-cyclic-adenosine-3-5-monophosphate-signaling
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Martin F Rath, Michael J Bailey, Jong-So Kim, Anthony K Ho, Pascaline Gaildrat, Steven L Coon, Morten Møller, David C Klein
Pax4 is a homeobox gene that is known to be involved in embryonic development of the endocrine pancreas. In this tissue, Pax4 counters the effects of the related protein, Pax6. Pax6 is essential for development of the pineal gland. In this study we report that Pax4 is strongly expressed in the pineal gland and retina of the rat. Pineal Pax4 transcripts are low in the fetus and increase postnatally; Pax6 exhibits an inverse pattern of expression, being more strongly expressed in the fetus. In the adult the abundance of Pax4 mRNA exhibits a diurnal rhythm in the pineal gland with maximal levels occurring late during the light period...
February 2009: Endocrinology
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