keyword
https://read.qxmd.com/read/38529272/mannose-enhances-intestinal-immune-barrier-function-and-dextran-sulfate-sodium-salt-induced-colitis-in-mice-by-regulating-intestinal-microbiota
#21
JOURNAL ARTICLE
Yi Yang, Qiming Ma, Qingyu Wang, Lifeng Zhao, Hengshan Liu, Yanjun Chen
BACKGROUND: Inflammatory bowel disease (IBD) greatly affects human quality of life. Mannose has been reported to be used to treat IBD, but the mechanism is currently unknown. METHODS: C57/BL mice were used as research subjects, and the mouse acute colitis model was induced using dextran sulfate sodium salt (DSS). After oral administration of mannose, the body weights and disease activity index (DAI) scores of the mice were observed. The colon lengths, histopathological sections, fecal content microbial sequencing, colon epithelial inflammatory genes, and tight junction protein Occludin-1 expression levels were measured...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529196/human-milk-microbiome-associations-with-maternal-diet-and-infant-growth
#22
JOURNAL ARTICLE
Tamara T Ajeeb, Emmanuel Gonzalez, Noel W Solomons, Marieke Vossenaar, Kristine G Koski
INTRODUCTION: Ingestion of human milk (HM) is identified as a significant factor associated with early infant gut microbial colonization, which has been associated with infant health and development. Maternal diet has been associated with the HM microbiome (HMM). However, a few studies have explored the associations among maternal diet, HMM, and infant growth during the first 6 months of lactation. METHODS: For this cross-sectional study, Mam -Mayan mother-infant dyads ( n  = 64) were recruited from 8 rural communities in the Western Highlands of Guatemala at two stages of lactation: early (6-46 days postpartum, n  = 29) or late (109-184 days postpartum, n  = 35)...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38528736/nonextractable-polyphenols-from-fu-brick-tea-alleviates-ulcerative-colitis-by-controlling-colon-microbiota-targeted-release-to-inhibit-intestinal-inflammation-in-mice
#23
JOURNAL ARTICLE
Chengcheng Yang, Wuqi Yang, Yu Wang, Yao Du, Tong Zhao, Hongjun Shao, Daoyuan Ren, Xingbin Yang
This study was designed to elucidate the colon microbiota-targeted release of nonextractable bound polyphenols (NEPs) derived from Fu brick tea and to further identify the possible anti-inflammatory mechanism in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice. 1.5% DSS drinking water-induced C57BL/6J mice were fed rodent chow supplemented with or without 8% NEPs or dietary fibers (DFs) for 37 days. The bound p -hydroxybenzoic acid and quercetin in NEPs were liberated up to 590.5 ± 70...
March 25, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38528147/an-expanded-transcriptome-atlas-for-bacteroides-thetaiotaomicron-reveals-a-small-rna-that-modulates-tetracycline-sensitivity
#24
JOURNAL ARTICLE
Daniel Ryan, Elise Bornet, Gianluca Prezza, Shuba Varshini Alampalli, Taís Franco de Carvalho, Hannah Felchle, Titus Ebbecke, Regan J Hayward, Adam M Deutschbauer, Lars Barquist, Alexander J Westermann
Plasticity in gene expression allows bacteria to adapt to diverse environments. This is particularly relevant in the dynamic niche of the human intestinal tract; however, transcriptional networks remain largely unknown for gut-resident bacteria. Here we apply differential RNA sequencing (RNA-seq) and conventional RNA-seq to the model gut bacterium Bacteroides thetaiotaomicron to map transcriptional units and profile their expression levels across 15 in vivo-relevant growth conditions. We infer stress- and carbon source-specific transcriptional regulons and expand the annotation of small RNAs (sRNAs)...
March 25, 2024: Nature Microbiology
https://read.qxmd.com/read/38527055/inflammatory-response-in-dairy-cows-caused-by-heat-stress-and-biological-mechanisms-for-maintaining-homeostasis
#25
JOURNAL ARTICLE
Hana Kim, Jang-Hoon Jo, Hong-Gu Lee, Woncheoul Park, Hak-Kyo Lee, Jong-Eun Park, Donghyun Shin
Climate change increases global temperatures, which is lethal to both livestock and humans. Heat stress is known as one of the various livestock stresses, and dairy cows react sensitively to high-temperature stress. We aimed to better understand the effects of heat stress on the health of dairy cows and observing biological changes. Individual cows were divided into normal (21-22 °C, 50-60% humidity) and high temperature (31-32 °C, 80-95% humidity), respectively, for 7-days. We performed metabolomic and transcriptome analyses of the blood and gut microbiomes of feces...
2024: PloS One
https://read.qxmd.com/read/38526572/first-exploration-of-the-altered-microbial-gut-lung-axis-in-the-pathogenesis-of-human-refractory-chronic-cough
#26
JOURNAL ARTICLE
Simone Baldi, Alessio Fabbrizzi, Leandro Di Gloria, Marco Pallecchi, Giulia Nannini, Mario D'Ambrosio, Cristina Luceri, Gianluca Bartolucci, Matteo Ramazzotti, Giovanni Fontana, Claudia Mannini, Federico Lavorini, Amedeo Amedei
PURPOSE: Cough represents a natural mechanism that plays an important defensive role in the respiratory tract, but in some conditions, it may become persistent, nonproductive, and harmful. In general, refractory chronic cough (RCC) occurs in about 20% of individuals; hence, we aimed to assess the presence of altered gut-lung communication in RCC patients through a compositional and functional characterization of both gut (GM) and oral microbiota (OM). METHODS: 16S rRNA sequencing was used to characterize both GM and OM composition of RCC patients and healthy controls (HC)...
March 25, 2024: Lung
https://read.qxmd.com/read/38526030/causal-effect-of-gut-microbiota-on-pancreatic-cancer-a-mendelian-randomization-and-colocalization-study
#27
JOURNAL ARTICLE
Xin Li, Zhihai Liang
The causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains unclear. This study aimed to investigate the potential genes underlying this mechanism. GM Genome-wide association study (GWAS) summary data were from the MiBioGen consortium. PC GWAS data were from the National Human Genome Research Institute-European Bioinformatics Institute (NHGRI-EBI) GWAS Catalogue. To detect the causal relationship between GM and PC, we implemented three complementary Mendelian randomization (MR) methods: Inverse Variance Weighting (IVW), MR-Egger and Weighted Median, followed by sensitivity analyses...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38525555/lactiplantibacillus-plantarum-strains-kabp011-kabp012-and-kabp013-modulate-bile-acids-and-cholesterol-metabolism-in-humans
#28
JOURNAL ARTICLE
T Padro, V de Santisteban, P Huedo, M Puntes, M Aguiló, J Espadaler-Mazo, L Badimon
AIMS: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012 and KABP013 on bile acid (BA), lipid profile and lipoprotein function. METHODS AND RESULTS: Healthy overweight individuals were included in this study...
March 25, 2024: Cardiovascular Research
https://read.qxmd.com/read/38525276/endosymbiont-and-gut-bacterial-communities-of-the-brown-banded-cockroach-supella-longipalpa
#29
JOURNAL ARTICLE
Kylene Guse, Jose E Pietri
The brown-banded cockroach ( Supella longipalpa ) is a widespread nuisance and public health pest. Like the German cockroach ( Blattella germanica ), this species is adapted to the indoor biome and completes the entirety of its life cycle in human-built structures. Recently, understanding the contributions of commensal and symbiotic microbes to the biology of cockroach pests, as well as the applications of targeting these microbes for pest control, have garnered significant scientific interest. However, relative to B...
2024: PeerJ
https://read.qxmd.com/read/38524400/evaluation-of-the-probiotic-potential-of-yeast-isolated-from-kombucha-in-new-zealand
#30
JOURNAL ARTICLE
Boying Wang, Kay Rutherfurd-Markwick, Ninghui Liu, Xue-Xian Zhang, Anthony N Mutukumira
The current study investigated the in vitro probiotic potential of yeast isolated from kombucha, a tea beverage fermented with a symbiotic culture of acetic acid bacteria and yeast. A total of 62 yeast strains were previously isolated from four different commercial kombucha samples sold in New Zealand. Fifteen representative isolates belonging to eight different species were evaluated for their growth under different conditions (temperature, low pH, concentrations of bile salts, and NaCl). Cell surface characteristics, functional and enzymatic activities of the selected strains were also studied in triplicate experiments...
2024: Current research in food science
https://read.qxmd.com/read/38524237/detection-of-typical-indigenous-gut-bacteria-related-to-kanpyo-lagenaria-siceraria-var-hispida-powder-in-murine-caecum-and-human-faecal-cultures
#31
JOURNAL ARTICLE
Mahiro Yamamoto, Hikaru Ogura, Takashi Kuda, Yumeng Xia, Ayaka Nakamura, Hajime Takahashi, Junji Inoue, Shu Takayanagi
Kanpyo (KP) is an edible dried product produced by peeling the fruit of the gourd Lagenaria siceraria var . hispida ; it is used in the traditional Japanese cuisine. The health functionality of KP due to its rich dietary fibre is expected to include a possible combined effect of KP-responsive indigenous gut bacteria (KP-RIB). However, its effect on the gut microbiota is unclear. To determine the effects of the KP on the gut microbiota and their host, Institute of Cancer Research mice were fed a high-sucrose diet containing no fibre (NF) or 5% (w/w) KP for 14 days, and their caecal microbiota was analysed by 16S rRNA (V4) amplicon sequencing...
April 2024: 3 Biotech
https://read.qxmd.com/read/38524178/construction-and-validation-of-a-machine-learning-model-for-the-diagnosis-of-juvenile-idiopathic-arthritis-based-on-fecal-microbiota
#32
JOURNAL ARTICLE
Jun-Bo Tu, Wei-Jie Liao, Si-Ping Long, Meng-Pan Li, Xing-Hua Gao
PURPOSE: Human gut microbiota has been shown to be significantly associated with various inflammatory diseases. Therefore, this study aimed to develop an excellent auxiliary tool for the diagnosis of juvenile idiopathic arthritis (JIA) based on fecal microbial biomarkers. METHOD: The fecal metagenomic sequencing data associated with JIA were extracted from NCBI, and the sequencing data were transformed into the relative abundance of microorganisms by professional data cleaning (KneadData, Trimmomatic and Bowtie2) and comparison software (Kraken2 and Bracken)...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38523788/detailed-survey-of-an-in%C3%A2-vitro-intestinal-epithelium-model-by-single-cell-transcriptomics
#33
JOURNAL ARTICLE
Ran Ran, Javier Muñoz Briones, Smrutiti Jena, Nicole L Anderson, Matthew R Olson, Leopold N Green, Douglas K Brubaker
The co-culture of two adult human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as an in vitro gut mimic, yet the translatability of insights from such a system to adult human physiological contexts is not fully characterized. Here, we used single-cell RNA sequencing on the co-culture to obtain a detailed survey of cell type heterogeneity in the system and conducted a holistic comparison with human physiology. We identified the intestinal stem cell-, transit amplifying-, enterocyte-, goblet cell-, and enteroendocrine-like cells in the system...
April 19, 2024: IScience
https://read.qxmd.com/read/38523409/a-guide-to-germ-free-and-gnotobiotic-mouse-technology-to-study-health-and-disease
#34
REVIEW
Maude Jans, Lars Vereecke
The intestinal microbiota has major influence on human physiology and modulates health and disease. Complex host-microbe interactions regulate various homeostatic processes, including metabolism and immune function, while disturbances in microbiota composition (dysbiosis) are associated with a plethora of human diseases and are believed to modulate disease initiation, progression and therapy response. The vast complexity of the human microbiota and its metabolic output represents a great challenge in unraveling the molecular basis of host-microbe interactions in specific physiological contexts...
March 24, 2024: FEBS Journal
https://read.qxmd.com/read/38522760/the-interactions-between-traditional-chinese-medicine-and-gut-microbiota-in-cancers-current-status-and-future-perspectives
#35
JOURNAL ARTICLE
Xuejiao Wei, Fei Wang, Peng Tan, Huiming Huang, Zhuguo Wang, Jinxin Xie, Longyan Wang, Dongxiao Liu, Zhongdong Hu
The gut microbiota, known as the "forgotten organ" and "human second genome," comprises a complex microecosystem. It significantly influences the development of various tumors, including colorectal, liver, stomach, breast, and lung cancers, through both direct and indirect mechanisms. These mechanisms include the "gut-liver" axis, the "lung-intestine" axis, and interactions with the immune system. The intestinal flora exhibits dual roles in cancer, both promoting and suppressing its progression. Traditional Chinese medicine (TCM) can alter cancer progression by regulating the intestinal flora...
March 22, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38522483/microbiome-interactions-with-different-risk-factors-in-development-of-myocardial-infarction
#36
REVIEW
Manisha Bijla, Sunil Kumar Saini, Ajai Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites...
March 22, 2024: Experimental Gerontology
https://read.qxmd.com/read/38522229/exposure-to-environmental-toxicants-is-associated-with-gut-microbiome-dysbiosis-insulin-resistance-and-obesity
#37
JOURNAL ARTICLE
Partho Sen, Yong Fan, Jennifer J Schlezinger, Stanislav D Ehrlich, Thomas F Webster, Tuulia Hyötyläinen, Oluf Pedersen, Matej Orešič
Environmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs are linked with obesity and insulin resistance partly through a dysbiotic gut microbiota and changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- and polyfluoroalkyl substances (PFAS) and additional twenty-seven ETs were measured by mass spectrometry in 264 Danes (121 men and 143 women, aged 56.6 ± 7.3 years, BMI 29.7 ± 6.0 kg/m2 ) using a combination of targeted and suspect screening approaches...
March 20, 2024: Environment International
https://read.qxmd.com/read/38522195/immobilisation-remediation-of-arsenic-contaminated-soils-with-promising-caal-layered-double-hydroxide-and-bioavailability-bioaccessibility-and-speciation-based-health-risk-assessment
#38
JOURNAL ARTICLE
Xiao-Chen Chen, Zhen-Jia Huang, Ao Wang, Jian-Ying Yu, Jian-Yu Zhang, Zi-Jun Xiao, Xiao-Yu Cui, Xian-Hua Liu, Nai-Yi Yin, Yan-Shan Cui
Arsenic (As)-contaminated soil poses great health risk to human mostly through inadvertent oral exposure. We investigated CaAl-layered double hydroxide (CaAl-LDH), a promising immobilising agent, for the remediation of As-contaminated Chinese soils. The effects on specific soil properties and As fractionation were analyzed, and changes in the health risk of soil As were accurately assessed by means of advanced in vivo mice model and in vitro PBET-SHIME model. Results showed that the application of CaAl-LDH significantly increased soil pH and concentration of Fe and Al oxides, and effectively converted active As fractions into the most stable residual fraction, guaranteeing long-term remediation stability...
March 22, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38521930/human-derived-bacterial-strains-mitigate-colitis-via-modulating-gut-microbiota-and-repairing-intestinal-barrier-function-in-mice
#39
JOURNAL ARTICLE
Juanjuan Dai, Mingjie Jiang, Xiaoxin Wang, Tao Lang, Leilei Wan, Jingjing Wang
BACKGROUND: Unbalanced gut microbiota is considered as a pivotal etiological factor in colitis. Nevertheless, the precise influence of the endogenous gut microbiota composition on the therapeutic efficacy of probiotics in colitis remains largely unexplored. RESULTS: In this study, we isolated bacteria from fecal samples of a healthy donor and a patient with ulcerative colitis in remission. Subsequently, we identified three bacterial strains that exhibited a notable ability to ameliorate dextran sulfate sodium (DSS)-induced colitis, as evidenced by increased colon length, reduced disease activity index, and improved histological score...
March 23, 2024: BMC Microbiology
https://read.qxmd.com/read/38521774/multi-omic-integration-of-microbiome-data-for-identifying-disease-associated-modules
#40
JOURNAL ARTICLE
Efrat Muller, Itamar Shiryan, Elhanan Borenstein
Multi-omic studies of the human gut microbiome are crucial for understanding its role in disease across multiple functional layers. Nevertheless, integrating and analyzing such complex datasets poses significant challenges. Most notably, current analysis methods often yield extensive lists of disease-associated features (e.g., species, pathways, or metabolites), without capturing the multi-layered structure of the data. Here, we address this challenge by introducing "MintTea", an intermediate integration-based approach combining canonical correlation analysis extensions, consensus analysis, and an evaluation protocol...
March 23, 2024: Nature Communications
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