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Pneumonitis lupus

Akash Roy, Bhattacharya Pk, Lyngdoh M, M D Jamil, Talukdar K
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Avinash Rao U, H K Aggarwal
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Noha Abdel-Wahab, Mohsin Shah, Maria E Suarez-Almazor
BACKGROUND: Three checkpoint inhibitor drugs have been approved by the US Food and Drug Administration for use in specific types of cancers. While the results are promising, severe immunotherapy-related adverse events (irAEs) have been reported. OBJECTIVES: To conduct a systematic review of case reports describing the occurrence of irAEs in patients with cancer following checkpoint blockade therapy, primarily to identify potentially unrecognized or unusual clinical findings and toxicity...
2016: PloS One
Caihong Ji, Xing Yu, Yong Wang, Lufeng Shi
Intestinal pseudo-obstruction (IpsO) and acute lupus pneumonitis (ALP) are uncommon severe complications of systemic lupus erythematosus (SLE). The present study reports the case of a 26-year-old female who presented with abdominal pain, nausea and vomiting as initial symptoms. Computed tomography (CT) scanning revealed the jejunal wall was thickened and streaky, mimicking the presentation of intestinal obstruction. Following emergency surgery, the patient's general condition was aggravated, with evident limb erythematous rashes...
July 2016: Experimental and Therapeutic Medicine
H K Aggarwal, D Jain, A Mittal, A Rao, R K Yadav, P Jain
We report a case of 19 year-old female patient diagnosed as systemic lupus erythematosus (SLE) presented with fever and diffuse cutaneous lesions. During the hospital stay she had acute pneumonia, pleural effusion and respiratory failure, which required intensive care unit (ICU) care and mechanical ventilator support. A fulminant course of the disease, decreased values of complement levels and positive antinuclear antibodies (ANA) in pleural fluid and repeated negative sputum for acid-fast bacillus, blood cultures enabled diagnosis of fulminant lupus pneumonitis...
June 23, 2016: Reumatismo
S A Wan, C L Teh, A T Jobli
Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with lupus pneumonitis during the initial SLE manifestation from March 2006 to March 2015. Results There were a total of five patients in our study who presented with fever and cough as the main clinical features. All patients had pulmonary infiltrates on chest radiographs...
November 2016: Lupus
Matiuallah Naqibullah, Saher B Shaker, Karen S Bach, Elisabeth Bendstrup
Rituximab (RTX), a mouse/human chimeric anti-CD20 IgG1 monoclonal antibody has been effectively used as a single agent or in combination with chemotherapy regimen to treat lymphoma since 1997. In addition, it has been used to treat idiopathic thrombocytopenic purpura, systemic lupus erythematous, rheumatoid arthritis, and autoimmune hemolytic anemia. Recently, RTX has also been suggested for the treatment of certain connective tissue disease-related interstitial lung diseases (ILD) and hypersensitivity pneumonitis...
2015: European Clinical Respiratory Journal
V Furer, D Zisman, E Pokroy-Shapira, Y Molad, O Elkayam, D Paran
OBJECTIVES: Belimumab has recently been approved for the treatment of systemic lupus erythematosus (SLE) refractory to standard therapy. Following one case of an SLE flare after cessation of belimumab, we hypothesized that this might lead to a rebound phenomenon and possible exacerbation of SLE. METHOD: Members of the Israeli Society of Rheumatology were contacted by e-mail and asked to report cases of an SLE flare following cessation of belimumab treatment. RESULTS: Three cases of SLE patients who experienced a severe SLE flare following cessation of belimumab therapy were reported...
2016: Scandinavian Journal of Rheumatology
Eva Rath, Shahin Zandieh, Alexander Löckinger, Mirko Hirschl, Klaus Klaushofer, Jochen Zwerina
Mixed connective tissue disease (MCTD) is a rare connective tissue disease frequently involving the lungs. The main characteristic is a systemic sclerosis-like picture of slowly progressing interstitial lung disease consistent with lung fibrosis, while pulmonary arterial hypertension is rare. Herein, we present a case of a newly diagnosed MCTD patient developing life-threatening acute pneumonitis similar to lupus pneumonitis. Previous literature on this exceptionally rare complication of MCTD is reviewed and differential diagnosis and management discussed...
October 2015: Wiener Klinische Wochenschrift
Eva N Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H Enk, Josef S Smolen, Georg H Stummvoll
INTRODUCTION: Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble those found in systemic lupus erythematosus (SLE). In addition, active SLE is associated with low Treg numbers and reduced Treg function, but direct evidence for a central role of Treg malfunction in the pathophysiology of lupus-like manifestations is still missing. In the present study, we characterize the multiorgan pathology, autoantibody profile and blood count abnormalities in scurfy mice and show their close resemblances to lupus-like disease...
2015: Arthritis Research & Therapy
B Chattopadhyay, A Chatterjee, A Maiti, N B Debnath
Acute lupus pneumonitis is a rare initial presentation of systemic lupus erythematosus (SLE). We report a 19-year-old female presenting with fever and recurrent hemoptysis with radiological evidence of parenchymal lung involvement with mild pleural effusion. Subsequent development of malar and discoid rash with anti-nuclear antibodies (ANA) and anti-dsDNA positivity clinched the diagnosis. Her clinical signs and symptoms resolved with a course of intravenous pulse methyl-prednisolone along with radiological resolution...
April 2015: Journal of Postgraduate Medicine
Jill Murie, Monica Agarwal
A 70-year-old woman presented with progressive skin lesions on the face, limbs and trunk in the absence of systemic illness. Three months earlier, she had been prescribed six months prophylactic nitrofurantoin for recurrent urinary tract infections, treated with nitrofurantoin and trimethoprim. Positive immunology and histological inflammatory changes in a skin biopsy were consistent with a diagnosis of sub-acute cutaneous lupus erythematosus. Following treatment with topical steroids, the skin lesions regressed, but alopecia followed and required hydroxychloroquine...
November 2014: Scottish Medical Journal
Mohammed Moizuddin, Muhammed Imtiaz, Mohammed Nayeem, Ria Gripaldo
Interstitial Lung Disease Case Report PostersSESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial Lung disease (ILD) is generally a late feature in patients with progressive systemic sclerosis (PSS). We report a rare case of 30 year old female patient who presented with acute respiratory distress syndrome, noted to have diffuse alveolar damage (DAD) on tranbronchial lung biopsy and elevated serum Scl-70 antibodies with no clinical evidence of SclerodermaCASE PRESENTATION: 30 year old non-smoker female patient with presented with progressively worsening shortness of breath, productive cough, and fever of three weeks duration...
October 1, 2014: Chest
Y-J A Chen, J-J Tseng, M-J Yang, Y-P Tsao, H-Y Lin
When the disease activity of systemic lupus erythematosus (SLE) is controlled appropriately, a pregnant woman who has lupus is able to carry safely to term and deliver a healthy infant. While the physiology of a healthy pregnancy itself influences ventilatory function, acute pulmonary distress may decrease oxygenation and influence both mother and fetus. Though respiratory failure in pregnancy is relatively rare, it remains one of the leading conditions requiring intensive care unit admission in pregnancy and carries a high risk of maternal and fetal morbidity and mortality, not to mention the complexity caused by lupus flare...
December 2014: Lupus
Yanju Zhang, Yunfei Xia, Songshi Ni, Zhifeng Gu, Hua Liu
OBJECTIVE: To investigate whether the umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in the MRL/lpr mice has effect or not on their pneumonitis and the possible mechanisms underlying this treatment. METHODS: Twenty four 18-week-old MRL/lpr female mice were divided into three groups as following: the group 2 (UC-MSCT group) have been transplanted with 1×10(6) UC-MSCs through caudal vein, the group 3 (multi-UC-MSCT Group) have been transplanted with 1×10(6) UC-MSCs three times and the group 1 (control group) have been treated with 0...
February 2014: Journal of Thoracic Disease
Y Tokano, H Ogasawara, S Ando, T Fujii, H Kaneko, N Tamura, T Yano, K Hirokawa, T Fukazawa, A Murashima, S Kobayashi, I Sekigawa, Y Takasaki, N Iida, H Hashimoto
Abstract To determine the efficacy of cyclosporin A (CysA) for the treatment of steroid-resistant interstitial pneumonitis (IP), we enrolled 25 patients with various rheumatic diseases and steroid-resistant IP in a pilot study [4 patients with rheumatoid arthritis (RA), 2 with systemic lupus erythematosus (SLE), 11 with polymyositis/dermatomyositis (PM/DM), 4 with systemic sclerosis (SSc), 1 with mixed connective tissue disease (MCTD), 3 with Sjögren syndrome (SS)]. Twelve patients (48%) showed a persistent response to CysA therapy, and 7 of them had PM/DM, including so-called amyopathic DM...
December 2002: Modern Rheumatology
Francisca Sabugo, Ricardo Espinoza-Araya, Manuel F Meneses, Miguel Cuchacovich
A woman with severe and longstanding systemic lupus erythematosus presented with a 1-week history of fever up to 38°C and pain in her right flank. Computed tomography scan of the chest revealed interstitial infiltrates and multiple nodules. Bronchoalveolar lavage did not show any inflammatory cells. Gram stain and cultures for aerobic and anaerobic bacteria, fungi, and Nocardia; acid-fast staining; polymerase chain reaction for tuberculosis, cytomegalovirus, herpesvirus 6, and parvovirus B19; and IF staining for pneumocystic and Legionella antigen were all negative...
January 2014: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Sylwia Senkowska, Bogumila Magiera, Ewelina Machura, Agata Maszczyk, Aleksandra Barylak, Bernadetta Adamczyk
The following paper discusses the aspect of respiratory system diseases, that are present in the course of systemic lupus erythematosus. Taking into consideration that SLE is a nonspecific systemic autoimmune condition, lungs as well as respiratory tract could be affected in the process of the disease. The main contributing factors are circulating antibodies and immune complexes, that are deposited in tissues. SLE affects mostly women in reproductive age and is characterized by variable intensity of symptoms...
October 2013: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Małgorzata H Starczewska, Liliana Wawrzyńska, Lucyna Opoka, Grzegorz Małek, Monika Wieliczko, Joanna Amatuszkiewicz-Rowińska, Monika Szturmowicz
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that is characterized by its chronic course and the involvement of many organs and systems. The most common abnormality in the respiratory system of SLE patients is lupus pleuritis. Less common is parenchymal involvement, which may present as acute lupus pneumonitis (ALP) or chronic interstitial lung disease. Other possible pulmonary manifestations of SLE include pulmonary embolism, diffuse alveolar haemorrhage, acute reversible hypoxaemia, and shrinking lung syndrome...
2013: Pneumonologia i Alergologia Polska
László Váróczy, Emese Kiss, Tünde Tarr, Margit Zeher, Gyula Szegedi, Arpád Illés
High-dose chemotherapy followed by autologous stem cell transplantation can be a rescue for patients with severe refractory systemic lupus erythematosus (SLE). However, the procedure might have fatal complications including infections and bleeding. We report on a young female patient with SLE whose disease started in her early childhood. After many years, severe renal, neurological, and bone marrow involvement developed that did not respond to conventional therapy. She was selected for autologous stem cell transplantation...
2012: Case Reports in Transplantation
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