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calcium urolithiasis

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https://www.readbyqxmd.com/read/27904915/studies-using-a-porcine-model-what-insights-into-human-calcium-oxalate-stone-formation-mechanisms-has-this-model-facilitated
#1
REVIEW
Kristina L Penniston, Sutchin R Patel, Denise J Schwahn, Stephen Y Nakada
Animal models are useful in the study of many human diseases. Our current understanding of the biological, physiological, and biochemical aspects of hyperoxaluria and calcium oxalate urolithiasis has been greatly informed by studies using animals. Recently, limitations in the extrapolation to humans of research results derived from laboratory rodents have been identified. The use in biomedical research of a variety of organisms, including large animals, is increasingly encouraged. The purpose of this article is to review the use of pigs in biomedical and stone research, to provide a rationale for using pigs in metabolic stone research, and to describe our 8-year experience in developing a porcine platform for studying hyperoxaluria and calcium oxalate urolithiasis...
November 30, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27882414/systemic-endothelial-function-measured-by-flow-mediated-dilation-is-impaired-in-patients-with-urolithiasis
#2
Esin Yencilek, Hakan Sarı, Faruk Yencilek, Ezgi Yeşil, Hasan Aydın
Some in vitro and animal studies have shown endothelial dysfunction in hyperoxaluria models indicating its role in pathogenesis of urolithiasis and relation to CVD. The aim of this study was to investigate endothelial function in patients with urolithiasis in relation to urinary stone risk factors and metabolic parameters. A total of 120 subjects without any known CVD (60 with urolithiasis and 60 healthy subjects) were included into study. Fasting blood and 24-h urine samples were collected to study metabolic parameters (glucose and lipids) and urine stone risk factors (oxalate, citrate, uric acid, and calcium, pH)...
November 23, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27876212/alteration-in-oxidative-nitrosative-imbalance-histochemical-expression-of-osteopontin-and-antiurolithiatic-efficacy-of-xanthium-strumarium-l-in-ethylene-glycol-induced-urolithiasis
#3
Padma Nibash Panigrahi, Sahadeb Dey, Monalisa Sahoo, Shyam Sundar Choudhary, Sumit Mahajan
Xanthium strumarium has traditionally been used in the treatment of urolitiasis especially by the rural people in India, but its antiurolithiatic efficacy was not explored scientifically till now. Therefore, the present study was designed to validate the ethnic practice scientifically, and explore the possible antiurolithiatic effect to rationalize its medicinal use. Urolitiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol (EG) for 28days along with 1% ammonium chloride (AC) for first 14days...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27875079/comparison-of-body-condition-score-and-urinalysis-variables-between-dogs-with-and-without-calcium-oxalate-uroliths
#4
Stephanie M Kennedy, Jody P Lulich, Michelle G Ritt, Eva Furrow
OBJECTIVE To compare body condition score (BCS) and urinalysis variables between dogs with and without calcium oxalate (CaOx) uroliths. DESIGN Case-control study. ANIMALS 46 Miniature Schnauzers, 16 Bichons Frises, and 6 Shih Tzus. PROCEDURES Medical records were reviewed for Miniature Schnauzers, Bichons Frises, and Shih Tzus that were examined between January 2001 and November 2014 for another urolithiasis study or for a urolith removal procedure. Dogs with CaOx uroliths were classified as cases. Dogs without a history of urinary tract disease and with no evidence of radiopaque uroliths on abdominal radiographs were classified as controls...
December 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27864113/chenopodium-album-linn-leaves-prevent-ethylene-glycol-induced-urolithiasis-in-rats
#5
Indu Sikarwar, Yadu Nandan Dey, Manish M Wanjari, Ajay Sharma, Sudesh N Gaidhani, Ankush D Jadhav
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Chenopodium album Linn. are traditionally used for correction of kidney diseases and urinary stones. The present work investigated the effect of methanolic and aqueous extracts of leaves of Chenopodium album on experimentally induced urolithiasis in rats to substantiate its traditional use as antilithiatic agent. MATERIALS AND METHODS: The leaf extract was standardized by HPLC. Urolithiasis was induced in rats by administration 0...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27853528/recent-advances-in-understanding-and-managing-urolithiasis
#6
REVIEW
Walter L Strohmaier
During the last few years, there has been relevant progress in both understanding and managing urolithiasis. Our knowledge of stone formation has changed; although the importance of urine biochemistry was questioned by several investigators years ago, the decisive role of cellular processes (induced by oxidative stress) and the renal papilla has only recently been generally accepted as the most important step in stone formation. For calcium oxalate urolithiasis, the formation of papillary calcifications plays a key role and is of prognostic relevance...
2016: F1000Research
https://www.readbyqxmd.com/read/27825989/antilithiatic-effect-of-peucedanum-grande-c-b-clarke-in-chemically-induced-urolithiasis-in-rats
#7
B N Kumar, Abdul Wadud, Nasreen Jahan, Ghulamuddin Sofi, Humaira Bano, Shaikh Ajij Ahmed Makbul, Sadique Husain
ETHNOPHARMACOLOGICAL RELEVANCE: Duqu (Peucedanum grande C. B. Clarke) has been used by Unani physicians since ancient times in retention of urine, renal and bladder calculi, nephritis and other associated disorders in different dosage forms. AIM OF THE STUDY: The aim of the study was to evaluate the antiurolithiatic activity of Peucedanum grande C. B. Clarke in experimental model. MATERIALS AND METHODS: The experiment was carried out in male Sprague Dawley rats divided into 5 groups of 8 animals each...
November 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27778049/geographic-location-is-an-important-determinant-of-risk-factors-for-stone-disease
#8
Ethan B Fram, Matthew D Sorensen, Vincent G Bird, Joshua M Stern
Some regions are known to have an increased burden of urolithiasis. Urolithiasis is known to be affected by weather patterns, particularly high ambient temperatures. To identify geographic differences in risk factors, we compared metabolic information for 1254 patients in two geographically distinct regions, New York and Florida, with per sample adjustment for ambient weather. We observed that patients in New York were more likely to have low urine volume, but also lower total urinary calcium (168 vs 216 mg, p = 0...
October 24, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27756957/effect-of-hydro-alcoholic-extract-of-vernonia-cinerea-less-against-ethylene-glycol-induced-urolithiasis-in-rats
#9
Ravindra D Hiremath, Sunil S Jalalpure
OBJECTIVE: Aim of this study is to evaluate antiurolithiatic potential of whole plant hydro-alcoholic (30:70) extract of Vernonia cinerea Less. in accordance to its claims made in ancient literature and also being one of the ingredients of cystone, a marketed formulation widely used in the management of urolithiasis. MATERIALS AND METHODS: To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative dose of 400 mg/kg b.w. and preventive doses of 100, 200, and 400 mg/kg b...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27748175/in-vitro-anti-urolithiasis-potentials-of-argemone-mexicana-l-leaves
#10
Chilivery Ravi Kiran, Sangilimuthu Alagar, D Priya Darsini Teepica
BACKGROUND: The current study was performed to evaluate the anti-urolithiatic activity of Argemone mexicana L. leaves extracts. METHODS: In vitro experiments (nucleation, aggregation and microscopic assay's) were performed to test the anti-urolithiasis activity of A. mexicana extracted using the four different solvents i.e. petroleum ether, chloroform, methanol, and water. These extracts were tested at increasing concentrations of 25, 50, 75 and 100 mg/ml and compared with the standard drug cystone...
October 10, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27744630/metabolic-risk-factors-in-pediatric-stone-formers-a-report-from-an-emerging-economy
#11
Kiran Imran, Mirza Naqi Zafar, Uzma Ozair, Sadia Khan, Syed Adibul Hasan Rizvi
The goal of this study was to investigate metabolic risk factors in pediatric stone formers in an emerging economy. A prospective, data collection enrolled 250 children age <1-15 years at our center. Risk factors were evaluated by gender and in age groups <1-5, 6-10 and 11-15 years. Patients were evaluated for demographics, blood and 24 h urine for calcium, magnesium, phosphate, uric acid, electrolytes and additional protein, citrate, ammonia and oxalate in urine. All reported values were two sided and statistical significance was considered at p value ≤0...
October 15, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27744629/difference-in-urinary-stone-composition-between-uyghur-and-han-children-with-urolithiasis
#12
Yang Liu, Anniwaer Yasheng, Kang Chen, Chuangxin Lan, Hamulati Tusong, Lili Ou, Yeping Liang, Hans-Göran Tiselius, Guohua Zeng, Wenqi Wu
The Objective of this study is to analyze the difference in renal stone composition between Uyghur and Han children with urolithiasis in China and possible reasons. From May 2011 to September 2013, we analyzed the stone compositions of 274 Chinese children with urolithiasis, including 151 Uyghur children from Xinjiang Province and 123 Han children from Guangdong Province. All the stone components were determined by Infrared spectroscopy and the main components were recorded. We also evaluated the data, including age, gender and geographic region of the patients...
October 15, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27742850/annals-express-late-diagnosis-of-primary-hyperoxaluria-type-iii-a-case-report
#13
Emmanuel Richard, Jean-Marc Blouin, Jerome Harambat, Brigitte Llanas, Stephane Bouchet, Cecile Acquaviva, Renaud De la Faille
We report the case of a 78-year-old patient with late diagnosis of hyperoxaluria type III (PH3). He developed renal failure after nephrectomy for clear cell papillary renal carcinoma and complained of recurrent urolithiasis for some 30 years whose etiology was never identified. Biochemical laboratory investigations of urine and urolithiasis composition revealed marked hyperoxaluria but normal levels of urinary glyceric and glycolic acid as well as stones of idiopathic calcium-oxalate appearance. Furthermore, the dietary survey showed excessive consumption of food supplements containing massive amounts of oxalate precursors...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27730307/calcium-oxalate-urolithiasis-in-children-urinary-promoters-inhibitors-and-role-of-their-ratios
#14
Daniel Turudic, Danica Batinic, Anja Tea Golubic, Mila Lovric, Danko Milosevic
: Diagnostic criteria for determination of inclination towards idiopathic calcium oxalate (CaOx) urolithiasis based on biochemical urine parameters are not sufficiently well defined in children. The aim of this study was to determine the risk of CaOx urolithiasis in children from concentrations of calcium, oxalate, citrate, and glycosaminoglycans in urine and their ratios, all standardized in respect to creatinine. We collected and analyzed 24-h urine samples of children with CaOx urolithiasis (n = 61) and compared with urine samples of matched control group of healthy children (n = 25)...
October 11, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27720363/blood-pressure-and-urolithiasis-in-children
#15
Louis Nikolis, Casey Seideman, Lane S Palmer, Pamela Singer, Nataliya Chorny, Rachel Frank, Lulette Infante, Christine B Sethna
INTRODUCTION: Urolithiasis is a condition that is most commonly found in adults, but is becoming increasingly prevalent in children. Little is known about the relationship between blood pressure (BP) and urolithiasis in children. OBJECTIVES: The aim was to evaluate the relationship between urolithiasis and BP, and to determine the association of BP with 24-h urine parameters in children. METHODS: We retrospectively analyzed BP and 24-h urine data from children <18 years with and without urolithiasis from 2004 to 2015 at a single tertiary center...
September 18, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27717296/cystine-stone-formers-have-impaired-health-related-quality-of-life-compared-with-noncystine-stone-formers-a-case-referent-study-piloting-the-wisconsin-stone-quality-of-life-questionnaire-among-patients-with-cystine-stones
#16
Necole M Streeper, Margaret L Wertheim, Stephen Y Nakada, Kristina L Penniston
INTRODUCTION: Cystinuria is a rare cause of urolithiasis. Affected patients have an earlier onset and more aggressive disease than patients with other stone etiologies. We assessed the health-related quality of life (HRQOL) of cystine stone-forming patients using the disease-specific Wisconsin Stone Quality of Life questionnaire (WISQOL). METHODS: Cystine patients treated in our stone clinics (n = 12) completed the WISQOL; information about medical and stone histories was gathered...
November 8, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27649531/mechanistic-insights-into-the-antilithiatic-proteins-from-terminalia-arjuna-a-proteomic-approach-in-urolithiasis
#17
Amisha Mittal, Simran Tandon, Surender Kumar Singla, Chanderdeep Tandon
Kidney stone formation during hyperoxaluric condition is inherently dependent on the interaction between renal epithelial cells and calcium oxalate (CaOx) crystals. Although modern medicine has progressed in terms of removal of these stones, recurrence and persistent side effects restricts their use. Strategies involving plant based agents which could be used as adjunct therapy is an area which needs to be explored. Plant proteins having antilithiatic activity is a hitherto unexplored area and therefore, we conducted a detailed identification and characterization of antilithiatic proteins from Terminalia arjuna (T...
2016: PloS One
https://www.readbyqxmd.com/read/27639296/tamsulosin-for-urolithiasis-a-review-of-the-recent-literature-and-current-controversies
#18
Ali Pourmand, Rahul Nadendla, Maryann Mazer-Amirshahi, Francis O'Connell
In the United States, urolithiasis affects approximately 1 in 11 people, and there is evidence that the prevalence is increasing. A relatively recent treatment strategy for urolithiasis involves using medical expulsive therapy (MET) to increase the likelihood of spontaneous passage of ureteral stones. The 2 leading drug classes for MET are alpha-1-andrenergic receptor blockers and calcium channel blockers. Tamsulosin, an alpha-1-adrenocepter blocking agent, is thought to induce spontaneous stone passage by relaxing ureteral smooth muscle tone...
September 8, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27634734/risk-of-chronic-kidney-disease-in-brushite-stone-formers-compared-to-idiopathic-calcium-oxalate-stone-formers
#19
Marcelino Rivera, Chris Jaeger, Daniel Yelfimov, Amy Krambeck
OBJECTIVE: To study brushite stone formers (BSF) change in renal function and overall risk of progression to chronic kidney disease (CKD) over time. MATERIALS AND METHODS: A retrospective review of all patients with urolithiasis on stone analysis was performed from 1995-2003. Stones were classified as brushite if they had at least 10% brushite composition on analysis. Patients with a minimum of 6 years clinical follow-up were included in the study. BSF were matched 1:3 to idiopathic calcium oxalate stone formers (CaOxSF) over the same time period...
September 12, 2016: Urology
https://www.readbyqxmd.com/read/27562981/feline-calcium-oxalate-urolithiasis-risk-factors-and-rational-treatment-approaches
#20
REVIEW
Joseph W Bartges
PRACTICAL RELEVANCE: Uroliths occur commonly in the bladder and/or urethra of cats and can be lifethreatening if urethral obstruction occurs. Calcium oxalate accounts for 40-50% of urocystoliths and these stones are not amenable to medical dissolution; therefore, removal by surgery or minimally invasive techniques is required if uroliths must be treated. Medical protocols for prevention involve decreasing urine saturation for minerals that form uroliths. ETIOPATHOGENESIS: Formation of uroliths is not a disease, but rather a complication of several disorders...
September 2016: Journal of Feline Medicine and Surgery
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