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calcium urolithiasis

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https://www.readbyqxmd.com/read/28207316/calcium-sulfate-dihydrate-urolithiasis-in-a-pet-rabbit
#1
Jaroslav Kucera, Tamara Koristkova, Barbora Gottwaldova, Vladimir Jekl
CASE DESCRIPTION A 3-year-old sexually intact male rabbit (Oryctolagus cuniculus) was evaluated because of a 1-day history of signs of anorexia and depression. CLINICAL FINDINGS Clinical examination revealed signs of depression, hunched posture, low skin elasticity (suggesting dehydration), slightly distended abdomen, and penile and preputial edema. The owner reported that the rabbit had been fed a routine diet, received water via a sipper bottle, and was allowed free movement around the home. It had been observed by the owner to bite and chew gypsum-based plaster from the walls of the home...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28181139/cytoprotective-and-anti-apoptotic-role-of-terminalia-arjuna-on-oxalate-injured-renal-epithelial-cells
#2
Amisha Mittal, Simran Tandon, Surender Kumar Singla, Chanderdeep Tandon
Urolithiasis is one of the painful multifactorial disorders caused by metabolic abnormalities influencing the composition of body fluids and urine. The bark of Terminalia arjuna (T. arjuna), very well known in Ayurveda for the treatment of cardiovascular diseases, possesses antioxidant and diuretic activity. The present study was undertaken to investigate the antiurolithiatic efficacy of aqueous extract of bark of T. arjuna on oxalate-induced injury to renal tubular epithelial cells. Madin-Darby canine kidney (MDCK) cells were exposed to 2 mM oxalate for 48 h to evaluate the protective effect of T...
February 8, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28125004/antioxidant-pre-treatment-reduces-the-toxic-effects-of-oxalate-on-renal-epithelial-cells-in-a-cell-culture-model-of-urolithiasis
#3
Tomislav Kizivat, Martina Smolić, Ivana Marić, Maja Tolušić Levak, Robert Smolić, Ines Bilić Čurčić, Lucija Kuna, Ivan Mihaljević, Aleksandar Včev, Sandra Tucak-Zorić
Urolithiasis is characterized by the formation and retention of solid crystals within the urinary tract. Kidney stones are mostly composed of calcium oxalate, which predominantly generates free radicals that are toxic to renal tubular cells. The aim of the study is to explore possible effects of antioxidant pre-treatment on inhibition of oxidative stress. Three cell lines were used as in vitro model of urolithiasis: MDCK I, MDCK II and LLC-PK1. Oxidative stress was induced by exposure of cells to sodium oxalate in concentration of 8 mM...
January 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28123331/prevalence-of-hypercalciuria-and-urinary-calcium-excretion-in-school-aged-children-in-the-province-of-tokat
#4
Ali Gül, Samet Özer, Resul Yılmaz, Ergün Sönmezgöz, Tuba Kasap, Şahin Takçı, Erhan Karaaslan, Yalçın Önder, Rıza Çıtıl, İlknur Bütün, Osman Demir
AIM: Hypercalciuria is an important cause of urinary tract symptoms, and also frequently results in urolithiasis. Urinary calcium excretion varies for geographic areas. We aimed to assess percentiles of urinary calcium excretion and prevalence of hypercalciuria for school-aged children in Tokat (city located in inner northern region of Turkey). MATERIAL AND METHODS: One thousand three hundred seventy-five children aged 6 to 18 years were enrolled in the study. Urine samples were obtained randomly...
December 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28042154/analysis-of-canine-urolith-submissions-to-the-canadian-veterinary-urolith-centre-1998-2014
#5
Doreen M Houston, Heather E Weese, Nick P Vanstone, Andrew E P Moore, J Scott Weese
Understanding urolith trends and risk factors is important for understanding urolithiasis, which is a common problem in dogs. This study evaluated 75 674 canine cystolith submissions to the Canadian Veterinary Urolith Centre between 1998 and 2014. Struvite and calcium oxalate uroliths comprised 80.8% of all uroliths, with calcium oxalate outnumbering struvite. There were significant increases in the proportions of calcium oxalate, mixed and cystine uroliths, and significant decreases in struvite, urate, silica, and calcium phosphate carbonate over the study period...
January 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28005930/nanoparticle-tracking-analysis-for-the-enumeration-and-characterization-of-mineralo-organic-nanoparticles-in-feline-urine
#6
M Mellema, M Stoller, Y Queau, S P Ho, T Chi, J A Larsen, N Passlack, A J Fascetti, C Mohr, J L Westropp
Urinary stone disease, particularly calcium oxalate, is common in both humans and cats. Calcifying nanoparticles (CNP) are spherical nanocrystallite material, and are composed of proteins (fetuin, albumin) and inorganic minerals. CNP are suggested to play a role in a wide array of pathologic mineralization syndromes including urolithiasis. We documented the development of a clinically relevant protocol to assess urinary CNP in 9 healthy cats consuming the same diet in a controlled environment using Nanoparticle Tracking Analysis (NTA®)...
2016: PloS One
https://www.readbyqxmd.com/read/27993822/calcitriol-mediated-hypercalcaemia-with-silicone-granulomas-due-to-cosmetic-injection
#7
Stephen Melnick, Ana Abaroa-Salvatierra, Mrunalini Deshmukh, Arti Patel
We present a case of a 41-year-old woman with medical history significant for urolithiasis presenting to our hospital for psychiatric evaluation due to worsening depression and suicidal ideations for the past 2 weeks. Initial laboratory results show hypercalcaemia of 13.5 mg/mL that led to consulting internal medicine. On further questioning, the patient admitted to cosmetic silicone injections in her buttocks which were causing calcium deposition under her skin, leading to disfigurement of the sacrum and lumbar regions...
December 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27974930/oxidative-stress-and-antioxidant-status-in-patients-with-complicated-urolithiasis
#8
Ceban E, Banov P, Galescu A, Botnari V
In recent years, intense efforts have been made to clarify the pathogenesis of urolithiasis, which affects more than 10% of the population of developed countries. Currently, a number of studies have assumed a key role in the pathogenesis of oxalate urolithiasis, which is the most common one that belongs to the active forms of oxygen generated in the kidney, as a result of the activation of free radical oxidation that occurs in the interaction of calcium oxalate crystals with renal tubular epithelial cells. In the current work, oxidant and antioxidant status were assessed in the blood of patients with complicated urolithiasis pre - and post surgery...
July 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27960541/high-frequency-dusting-versus-conventional-holmium-laser-lithotripsy-for-intrarenal-and-ureteral-calculi
#9
Roger Li, David Ruckle, Mohamed Keheila, Jonathan Maldonado, Michelle Lightfoot, Muhannad Alsyouf, Alexander Yeo, Samuel R Abourbih, Gaudencio Olgin, Javier L Arenas, D Duane Baldwin
INTRODUCTION: The efficiency of holmium laser lithotripsy for urolithiasis depends upon several factors, including laser pulse energy and frequency and stone composition and retropulsion. This study investigates the complex interplay between these factors and quantifies lithotripsy efficiency using different laser settings in a benchtop kidney and ureter model. MATERIALS AND METHODS: In vitro caliceal and ex vivo porcine ureteral models were constructed. Calcium oxalate monohydrate stones were fragmented using a 200-μm laser fiber...
January 16, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27942796/calcium-urolithiasis-course-in-young-stone-formers-is-influenced-by-the-strength-of-family-history-results-from-a-retrospective-study
#10
Angela Guerra, Andrea Ticinesi, Franca Allegri, Antonio Nouvenne, Silvana Pinelli, Fulvio Lauretani, Marcello Maggio, Gianfranco Cervellin, Loris Borghi, Tiziana Meschi
The role of the strength of family history of stones (FHS), i.e., degree of relatives with the disease, on the course of calcium urolithiasis (CU) is not fully understood, particularly in young patients where genetic background has the greatest influence on disease expression. Thus, with a retrospective cross-sectional design, we examined baseline clinical parameters and urinary chemistries of 369 subjects (196 M) with CU and 96 controls (41 M) aged between 15 and 25 at the time of the first visit at our stone clinic...
December 9, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27904915/studies-using-a-porcine-model-what-insights-into-human-calcium-oxalate-stone-formation-mechanisms-has-this-model-facilitated
#11
REVIEW
Kristina L Penniston, Sutchin R Patel, Denise J Schwahn, Stephen Y Nakada
Animal models are useful in the study of many human diseases. Our current understanding of the biological, physiological, and biochemical aspects of hyperoxaluria and calcium oxalate urolithiasis has been greatly informed by studies using animals. Recently, limitations in the extrapolation to humans of research results derived from laboratory rodents have been identified. The use in biomedical research of a variety of organisms, including large animals, is increasingly encouraged. The purpose of this article is to review the use of pigs in biomedical and stone research, to provide a rationale for using pigs in metabolic stone research, and to describe our 8-year experience in developing a porcine platform for studying hyperoxaluria and calcium oxalate urolithiasis...
February 2017: Urolithiasis
https://www.readbyqxmd.com/read/27882414/systemic-endothelial-function-measured-by-flow-mediated-dilation-is-impaired-in-patients-with-urolithiasis
#12
Esin Yencilek, Hakan Sarı, Faruk Yencilek, Ezgi Yeşil, Hasan Aydın
Some in vitro and animal studies have shown endothelial dysfunction in hyperoxaluria models indicating its role in pathogenesis of urolithiasis and relation to CVD. The aim of this study was to investigate endothelial function in patients with urolithiasis in relation to urinary stone risk factors and metabolic parameters. A total of 120 subjects without any known CVD (60 with urolithiasis and 60 healthy subjects) were included into study. Fasting blood and 24-h urine samples were collected to study metabolic parameters (glucose and lipids) and urine stone risk factors (oxalate, citrate, uric acid, and calcium, pH)...
November 23, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27876212/alteration-in-oxidative-nitrosative-imbalance-histochemical-expression-of-osteopontin-and-antiurolithiatic-efficacy-of-xanthium-strumarium-l-in-ethylene-glycol-induced-urolithiasis
#13
Padma Nibash Panigrahi, Sahadeb Dey, Monalisa Sahoo, Shyam Sundar Choudhary, Sumit Mahajan
Xanthium strumarium has traditionally been used in the treatment of urolitiasis especially by the rural people in India, but its antiurolithiatic efficacy was not explored scientifically till now. Therefore, the present study was designed to validate the ethnic practice scientifically, and explore the possible antiurolithiatic effect to rationalize its medicinal use. Urolitiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol (EG) for 28days along with 1% ammonium chloride (AC) for first 14days...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27875079/comparison-of-body-condition-score-and-urinalysis-variables-between-dogs-with-and-without-calcium-oxalate-uroliths
#14
Stephanie M Kennedy, Jody P Lulich, Michelle G Ritt, Eva Furrow
OBJECTIVE To compare body condition score (BCS) and urinalysis variables between dogs with and without calcium oxalate (CaOx) uroliths. DESIGN Case-control study. ANIMALS 46 Miniature Schnauzers, 16 Bichons Frises, and 6 Shih Tzus. PROCEDURES Medical records were reviewed for Miniature Schnauzers, Bichons Frises, and Shih Tzus that were examined between January 2001 and November 2014 for another urolithiasis study or for a urolith removal procedure. Dogs with CaOx uroliths were classified as cases. Dogs without a history of urinary tract disease and with no evidence of radiopaque uroliths on abdominal radiographs were classified as controls...
December 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27864113/chenopodium-album-linn-leaves-prevent-ethylene-glycol-induced-urolithiasis-in-rats
#15
Indu Sikarwar, Yadu Nandan Dey, Manish M Wanjari, Ajay Sharma, Sudesh N Gaidhani, Ankush D Jadhav
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Chenopodium album Linn. are traditionally used for correction of kidney diseases and urinary stones. The present work investigated the effect of methanolic and aqueous extracts of leaves of Chenopodium album on experimentally-induced urolithiasis in rats to substantiate its traditional use as antilithiatic agent. MATERIALS AND METHODS: The leaf extract was standardized by HPLC. Urolithiasis was induced in rats by administration of 0...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27853528/recent-advances-in-understanding-and-managing-urolithiasis
#16
REVIEW
Walter L Strohmaier
During the last few years, there has been relevant progress in both understanding and managing urolithiasis. Our knowledge of stone formation has changed; although the importance of urine biochemistry was questioned by several investigators years ago, the decisive role of cellular processes (induced by oxidative stress) and the renal papilla has only recently been generally accepted as the most important step in stone formation. For calcium oxalate urolithiasis, the formation of papillary calcifications plays a key role and is of prognostic relevance...
2016: F1000Research
https://www.readbyqxmd.com/read/27825989/antilithiatic-effect-of-peucedanum-grande-c-b-clarke-in-chemically-induced-urolithiasis-in-rats
#17
B N Kumar, Abdul Wadud, Nasreen Jahan, Ghulamuddin Sofi, Humaira Bano, Shaikh Ajij Ahmed Makbul, Sadique Husain
ETHNOPHARMACOLOGICAL RELEVANCE: Duqu (Peucedanum grande C. B. Clarke) has been used by Unani physicians since ancient times in retention of urine, renal and bladder calculi, nephritis and other associated disorders in different dosage forms. AIM OF THE STUDY: The aim of the study was to evaluate the antiurolithiatic activity of Peucedanum grande C. B. Clarke in experimental model. MATERIALS AND METHODS: The experiment was carried out in male Sprague Dawley rats divided into 5 groups of 8 animals each...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27778049/geographic-location-is-an-important-determinant-of-risk-factors-for-stone-disease
#18
Ethan B Fram, Matthew D Sorensen, Vincent G Bird, Joshua M Stern
Some regions are known to have an increased burden of urolithiasis. Urolithiasis is known to be affected by weather patterns, particularly high ambient temperatures. To identify geographic differences in risk factors, we compared metabolic information for 1254 patients in two geographically distinct regions, New York and Florida, with per sample adjustment for ambient weather. We observed that patients in New York were more likely to have low urine volume, but also lower total urinary calcium (168 vs 216 mg, p = 0...
October 24, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27756957/effect-of-hydro-alcoholic-extract-of-vernonia-cinerea-less-against-ethylene-glycol-induced-urolithiasis-in-rats
#19
Ravindra D Hiremath, Sunil S Jalalpure
OBJECTIVE: Aim of this study is to evaluate antiurolithiatic potential of whole plant hydro-alcoholic (30:70) extract of Vernonia cinerea Less. in accordance to its claims made in ancient literature and also being one of the ingredients of cystone, a marketed formulation widely used in the management of urolithiasis. MATERIALS AND METHODS: To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative dose of 400 mg/kg b.w. and preventive doses of 100, 200, and 400 mg/kg b...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27748175/in-vitro-anti-urolithiasis-potentials-of-argemone-mexicana-l-leaves
#20
Chilivery Ravi Kiran, Sangilimuthu Alagar, D Priya Darsini Teepica
BACKGROUND: The current study was performed to evaluate the anti-urolithiatic activity of Argemone mexicana L. leaves extracts. METHODS: In vitro experiments (nucleation, aggregation and microscopic assay's) were performed to test the anti-urolithiasis activity of A. mexicana extracted using the four different solvents i.e. petroleum ether, chloroform, methanol, and water. These extracts were tested at increasing concentrations of 25, 50, 75 and 100 mg/ml and compared with the standard drug cystone...
October 10, 2016: Current Clinical Pharmacology
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