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calcium urolithiasis

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https://www.readbyqxmd.com/read/28631902/-comparative-estimation-of-antilithogenic-activity-of-porcine-kidney-derived-biomedical-substance-and-sodium-citrate-in-experimental-urolithiasis
#1
G V Pavlyashik, A Yu Zharikov, V I Kiselev
AIM: to compare the anti-lithogenic activity of biomedical substance derived from freeze-dried porcine kidney and sodium citrate. MATERIALS AND METHODS: The experiments were conducted on Wistar rats divided into three groups of 15 animals each: control group (disease control), comparison group (sodium citrate treatment) and experimental group (treatment with biomedical substance from porcine kidneys). Experimental urolithiasis was modeled using the ethylene glycol model...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28616648/protective-effect-of-dietary-polyphenol-caffeic-acid-on-ethylene-glycol-induced-kidney-stones-in-rats
#2
Fauzia Yasir, Atia-Tul- Wahab, M Iqbal Choudhary
Dietary polyphenol caffeic acid (1) has been reported for various pharmacological activities. The aim of the current study was to investigate the effect of caffeic acid (1) on ethylene glycol-induced renal stones in rats. For the study, male Wistar rats were divided into seven groups; normal, pathological, and standard drug controls, and preventive and curative groups. Normal control group received drinking water for 8 weeks. Pathological, standard drug, preventive, and curative groups received 0.75% ethylene glycol in drinking water for the induction of calcium oxalate stone formation, along with the regular diet...
June 14, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28609763/calcium-sensing-receptor-genetic-polymorphisms-and-risk-of-developing-nephrolithiasis-in-a-chinese-population
#3
Qi Ding, Bo Fan, Ying Shi, Zhijiang Fan, Li Ding, Feng Li, Wenjian Tu, Xiaohua Jin, Chao Qin, Qiang Cao, Qinbo Yuan, Jing Wang, Jun Ouyang
OBJECTIVE: To evaluate the association between calcium-sensing receptor (CaSR) Arg990Gly (rs1042636, A > G), Ala986Ser (rs1801725, G > T) polymorphisms, and urolithiasis risk. METHODS: Polymorphisms mentioned above were genotyped in a hospital-based case-control study of 615 patients diagnosed with nephrolithiasis and 315 kidney stone-free controls in a Chinese population using the SNaPshot method. RESULTS: The results indicated a significantly increased risk associated with CaSR Arg990Gly GG genotypes (OR 1...
June 14, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28587907/-a-family-history-of-renal-lithiasis-in-children-diagnosed-of-urinary-tract-infection-by-escherichia-coli
#4
Víctor García Nieto, Jorge Sotoca Fernández, Monica O'Hagan, Pedro Arango Sancho, Maria Isabel Luis Yanes
INTRODUCTION: Urinary tract infections (UTI) caused by Escherichia coli (E. coli) are common in patients with idiopathic hypercalciuria. As both UTI and hypercalciuria (prelithiasis) have a genetic basis, we wanted to know whether the family history of urolithiasis is more common in children with UTIs caused by E. coli. Secondarily, we wondered if the renal scars are more common in children with prelithiasis. MATERIAL AND METHODS: Ambispective study with collected data from 104 patients (40 male, 64 female) followed after having been diagnosed of UTI by E...
June 3, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28585182/lime-powder-treatment-reduces-urinary-excretion-of-total-protein-and-transferrin-but-increases-uromodulin-excretion-in-patients-with-urolithiasis
#5
Piyaratana Tosukhowong, Pimsuda Kulpradit, Sakdithep Chaiyarit, Wattanachai Ungjareonwattana, Nuttiya Kalpongnukul, Supoj Ratchanon, Visith Thongboonkerd
Our previous study has shown that lime powder (LP) had an inhibitory effect against calcium oxalate stone formation. However, the precise mechanisms underlying such beneficial effect remained unclear. Our present study thus aimed to address the effect of LP on excretory level and compositions of urinary proteins using a proteomics approach. From a total of 80 calcium oxalate stone formers recruited into our 2-year randomized clinical trial of LP effect, 10 patients with comparable age and clinical parameters were selected for this proteomic study...
June 5, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28577929/mrp-1-and-bcrp-promote-the-externalization-of-phosphatidylserine-in-oxalate-treated-renal-epithelial-cells-implications-for-calcium-oxalate-urolithiasis
#6
YiFu Li, ShiLiang Yu, XiuGuo Gan, Ze Zhang, Yan Wang, YingWei Wang, RuiHua An
OBJECTIVES: To investigate the possible involvement of multidrug resistance-associated protein 1 (MRP-1) and breast cancer resistance protein (BCRP) in the oxalate-induced redistribution of phosphatidylserine (PS) in renal epithelial cell membranes. METHODS: A western blot analysis was used to examine the MRP-1 and BCRP expression levels. Surface-expressed PS was detected by the annexin V-binding assay. The cell-permeable fluorogenic probe 2,7-dichlorofluorescein diacetate (DCFH-DA) was used to measure the intracellular reactive oxygen species (ROS) level...
May 31, 2017: Urology
https://www.readbyqxmd.com/read/28569194/severe-child-form-of-primary-hyperoxaluria-type-2-a-case-report-revealing-consequence-of-grhpr-deficiency-on-metabolism
#7
Jana Konkoľová, Ján Chandoga, Juraj Kováčik, Marcel Repiský, Veronika Kramarová, Ivana Paučinová, Daniel Böhmer
BACKGROUND: Primary hyperoxaluria type 2 is a rare monogenic disorder inherited in an autosomal recessive pattern. It results from the absence of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GRHPR). As a consequence of deficient enzyme activity, excessive amounts of oxalate and L-glycerate are excreted in the urine, and are a source for the formation of calcium oxalate stones that result in recurrent nephrolithiasis and less frequently nephrocalcinosis. CASE PRESENTATION: We report a case of a 10-month-old patient diagnosed with urolithiasis...
May 31, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28567512/total-flavonoids-of-desmodium-styracifolium-attenuates-the-formation-of-hydroxy-l-proline-induced-calcium-oxalate-urolithiasis-in-rats
#8
Jianfu Zhou, Jing Jin, Xiong Li, Zhongxiang Zhao, Lei Zhang, Qian Wang, Jing Li, Qiuhong Zhang, Songtao Xiang
Desmosium styracifolium (D. styracifolium), which is considered as a Chinese herbal medicine, has been reported to treat the kidney stone diseases. However, the potential phytochemically active components and the underlying mechanisms associated with its efficacy in targeting urolithiasis remain to be elucidated. This study aims to investigate the anti-urolithiatic effect of total flavonoids of D. styracifolium (TFDS) on calcium oxalate (CaOx) renal stones in Sprague-Dawley rats. Animal models of CaOx urolithiasis were established in male Sprague-Dawley rats by adding 5% w/w hydroxy-L-proline (HLP) in regular rat chow...
May 31, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28560471/impact-of-laser-fiber-tip-cleavage-on-power-output-for-ureteroscopy-and-stone-treatment
#9
M Haddad, E Emiliani, Y Rouchausse, F Coste, L Berthe, S Doizi, S Buttice, B Somani, O Traxer
PURPOSE: Holmium:YAG laser is the most used laser for urolithiasis. Generally, we use metallic scissors to cut the fiber tip to restore its effectiveness. Many cleaving methods have been described to avoid fiber damage and to restore its greatest power to the fiber. There is a lack of information regarding which cleaving method should be used and its effect on the fiber. In order to compare these effects, we studied different cleavage methods in terms of power output and its effects on the fiber...
May 30, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28556535/mineral-composition-of-uroliths-obtained-from-sheep-and-goats-with-obstructive-urolithiasis
#10
M L Jones, P M Gibbons, A J Roussel, B J Dominguez
BACKGROUND: Knowledge of the mineral composition of the causative urolith is important to develop preventative strategies. Advances in analytic techniques have led to detection of urolith components not previously recognized. HYPOTHESIS/OBJECTIVES: The objectives of this study were to characterize uroliths in sheep and goats structurally and clinically. We hypothesized that amorphous magnesium calcium phosphate (AMCP) would be a naturally occurring urolith type in sheep and goats...
May 29, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28529700/effect-of-citrus-based-products-on-urine-profile-a-systematic-review-and-meta-analysis
#11
Fakhri Rahman, Ponco Birowo, Indah S Widyahening, Nur Rasyid
Background. Urolithiasis is a disease with high recurrence rate, 30-50% within 5 years. The aim of the present study was to learn the effects of citrus-based products on the urine profile in healthy persons and people with urolithiasis compared to control diet and potassium citrate.  Methods. A systematic review was performed, which included interventional, prospective observational and retrospective studies, comparing citrus-based therapy with standard diet therapy, mineral water, or potassium citrate. A literature search was conducted using PUBMED, COCHRANE, and Google Scholar with "citrus or lemonade or orange or grapefruit or lime or juice" and "urolithiasis" as search terms...
2017: F1000Research
https://www.readbyqxmd.com/read/28528955/potential-therapeutic-activity-of-phlogacanthus-thyrsiformis-hardow-mabb-flower-extract-and-its-biofabricated-silver-nanoparticles-against-chemically-induced-urolithiasis-in-male-wistar-rats
#12
Poppy Das, Kiran Kumar, Arunai Nambiraj, Reshma Rajan, Rajendra Awasthi, Kamal Dua, Himaja M
Urolithiasis is a painful disorder in which stones are formed in the kidney, bladder or urethra. There are no proper therapeutic treatments available for kidney stones and people suffering from larger stones have to undergo surgery which has many side effects. A natural remedy with therapeutic effects that can dissipate and remove even the larger stones would eliminate the need of a surgery and the risks associated with it. The flowers of Phlogacanthus thyrsiformis used in culinary recipes in the north eastern India are also widely used as a folklore medicine for the treatment of kidney stones and liver disorders...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28526618/24-hour-urine-metabolic-differences-between-solitary-and-multiple-stone-formers-results-of-the-collaboration-on-urolithiasis-in-pediatrics-cup-working-group
#13
Theodore R Saitz, Solange Mongoue-Tchokote, Cynthia Sharadin, Dana W Giel, Sean Corbett, Larisa Kovacevic, Aaron P Bayne
INTRODUCTION: Specific factors associated with the risk of developing pediatric urinary stone disease remain unclear, especially those that may be associated with recurrent stone disease. OBJECTIVE: We compared the results of 24-h urine collections in children with a solitary stone episode to those with multiple stone episodes to determine if there is a difference that may be associated with multiple stone formation in children. STUDY DESIGN: A multi-institutional retrospective analysis was completed to assess 24-h urinary metabolic profiles in children with urolithiasis aged 2-18 years old...
April 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28480348/antiurolithic-effect-of-olive-oil-in-a-mouse-model-of-ethylene-glycol-induced-urolithiasis
#14
Mohammed Alenzi, Shaik Rahiman, Bilal Ahmad Tantry
PURPOSE: At present, commercially available antiurolithic drugs have more adverse effects than potential therapeutic or preventive effects with chronic use. With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-induced urolithiasis. MATERIALS AND METHODS: Adult albino mice were divided into 6 groups. Group I was fed the vehicle only. Group II was supplemented with 0.75% EG alone in drinking water during the experimental period to initiate deposition of calcium oxalate in kidneys, which leads to urolithiasis in animals...
May 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28467511/urinary-metals-in-a-spontaneous-canine-model-of-calcium-oxalate-urolithiasis
#15
Eva Furrow, Molly E McCue, Jody P Lulich
Calcium oxalate urolithiasis is a common and painful condition in people. The pathogenesis of this disease is complex and poorly understood. Laboratory animal and in vitro studies have demonstrated an effect of multiple trace metals in the crystallization process, and studies in humans have reported relationships between urinary metal concentrations and stone risk. Dogs are a spontaneous model of calcium oxalate urolithiasis, and the metal content of canine calcium oxalate stones mirrors that of human stones...
2017: PloS One
https://www.readbyqxmd.com/read/28458875/a-rare-case-of-mediastinal-functioning-parathyroid-adenoma-removed-successfully-with-thoracoscopy
#16
Masashi Ishikawa, Shin-Ichi Sumitomo, Naoto Imamura, Tomoki Nishida, Katsutaka Mineura
We report here a rare case of primary hyperparathyroidism that was associated with an ectopic parathyroid adenoma located in the mediastinum. A 66-year-old woman suffering from primary hyperparathyroidism had been followed-up on an outpatient basis for over 10 years. She suffered from persistent urolithiasis and osteopenia due to hypercalcemia. After technetium-99-sestamibi (99mTc-MIBI) scintigraphy revealed an ectopic adenoma in the superior mediastinum, thoracoscopic resection of the tumor was performed. Subsequently, her serum parathyroid hormone (PTH) level decreased dramatically and her serum calcium concentration was restored to normal...
April 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28458427/antiurolithiatic-and-antioxidant-efficacy-of-musa-paradisiaca-pseudostem-on-ethylene-glycol-induced-nephrolithiasis-in-rat
#17
Padma Nibash Panigrahi, Sahadeb Dey, Monalisa Sahoo, Ananya Dan
OBJECTIVE: Musa paradisiaca has been used in the treatment of urolithiasis by the rural people in South India. Therefore, we plan to evaluate its efficacy and possible mechanism of antiurolithiatic effect to rationalize its medicinal use. MATERIALS AND METHODS: Urolithiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol (EG) for 28 days along with 1% ammonium chloride (AC) for the first 14 days. Antiurolithiatic effect of aqueous-ethanol extract of M...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28446830/bryophyllum-pinnatum-leaf-extracts-prevent-formation-of-renal-calculi-in-lithiatic-rats
#18
Mahendra Yadav, Vijay D Gulkari, Manish M Wanjari
BACKGROUND: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. AIM: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. MATERIALS AND METHODS: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28439382/association-between-adiponectin-and-insulin-resistance-in-diabetic-urolithiasis
#19
Dona Devasia, Kavitha Meiyappan, Palani Selvam Mohanraj, Dorairajan Lalgudi Narayanan, Gandhipuram Periyasamy Senthilkumar, Md Yasir
OBJECTIVES: The prevalence of urolithiasis is increasing worldwide. Diabetes mellitus (DM) is characterized by insulin resistance, which increases the risk of kidney stone formation. Adiponectin is an insulin-sensitizing and anti-inflammatory cytokine, which is known to improve glucose tolerance and insulin resistance in humans. The association of insulin and adiponectin with kidney stones is not clear. Hence, the present study aim to assess the serum levels of adiponectin and insulin resistance in DM patients with urolithiasis in comparison to those without...
March 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28435765/chronic-nephropathy-from-dietary-hyperoxaluria-sustained-improvement-of-renal-function-after-dietary-intervention
#20
Yijuan Sun, Bruce L Horowitz, Karen S Servilla, Joanna R Fair, Darlene Vigil, Kavitha Ganta, Larry Massie, Antonios H Tzamaloukas
A 56-year-old man with stable chronic kidney disease (CKD) for two years following a single episode of calcium oxalate urolithiasis developed progressive elevation of his serum creatinine concentration. Urinalysis revealed pyuria and white cell casts, a few red blood cells, minimal proteinuria, and no crystals. Urine culture was sterile. Gallium scintigraphy was consistent with interstitial nephritis. Proton pump inhibitor intake was discontinued, and a short course of oral corticosteroids was initiated. Percutaneous kidney biopsy, performed because of the continued deterioration of renal function to a minimum estimated glomerular filtration rate (eGFR) value of 15 mL/min per 1...
March 20, 2017: Curēus
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