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Cryoablation for renal cell cancer

Peter A Caputo, Homayoun Zargar, Daniel Ramirez, Hiury S Andrade, Oktay Akca, Tianming Gao, Jihad H Kaouk
BACKGROUND: The traditional treatment for a cT1b renal tumor has been radical nephrectomy. However, recent guidelines have shifted towards partial nephrectomy (PN) in selected patients with cT1b renal tumors. Furthermore, practitioners have extended the role of cryoablation (CA) to treat cT1b tumors in selected patients. OBJECTIVE: To evaluate the efficacy of CA compared to PN for cT1b renal tumors. DESIGN, SETTING, AND PARTICIPANTS: We performed a retrospective review of patients who underwent either renal CA (laparoscopic or percutaneous) or PN (robot-assisted) for a cT1b renal mass (>4cm and ≤7cm) between November 1999 and August 2014...
August 24, 2016: European Urology
Lasse L Nonboe, Tommy K Nielsen, Søren Høyer, Ole Graumann, Jørgen Frøkiær, Michael Borre
INTRODUCTION: The minimally invasive treatment of small renal masses with cryoablation has become increasingly widespread during the past 15 years. Studies with long-term follow-up are beginning to emerge, showing good oncological control, however, tumors with a central and endophytic location seem to possess an increased risk of treatment failure. Such tumors are likely to be subjected to a high volume of blood giving thermal protection to the cancerous cells. Arterial clamping during freezing might reduce this effect but at the same time subject the kidney to ischemia...
August 25, 2016: Technology in Cancer Research & Treatment
P J Zondervan, M Buijs, J J de la Rosette, O van Delden, K van Lienden, M P Laguna
INTRODUCTION: Cryoablation (CA) has been broadly used mostly in the treatment of small renal masses (SRMs). The present review aims to define the current role of CA in the treatment of SRMs by assessing clinical indications and outcomes. METHOD: A comprehensive review on patient selection, procedural details, perioperative complications, and short/long-term oncological and functional outcomes was conducted. For each section, a take-home message was formulated with level of evidence (LoE) according to Cochrane collaboration...
August 5, 2016: International Journal of Surgery
Zhamshid Okhunov, Joshua Chamberlin, Daniel M Moreira, Arvin George, Kara Babaian, Paras Shah, Ramy Youssef, Kamaljot S Kaler, Igor I Lobko, Louis Kavoussi, Jaime Landman
BACKGROUND: The management of locally recurrent renal-cell carcinoma (RCC) following cryoablation remains a clinical dilemma. There is limited data regarding the management of locally recurrent disease in the setting of patients who have failed initial percutaneous cryoablation (PCA). We evaluate and report our experience with salvage PCA for local recurrence following renal cryoablation failure. PATIENTS AND METHODS: We reviewed our experience with patients who underwent salvage PCA for local biopsy proven RCC recurrence following primary cryoablation procedures...
June 2016: Journal of Endourology
Florian J Fintelmann, Kemal Tuncali, Stefan Puchner, Debra A Gervais, Ashraf Thabet, Paul B Shyn, Ronald S Arellano, Servet Tatli, Peter R Mueller, Stuart G Silverman, Raul N Uppot
PURPOSE: To identify retrospectively predictors of catecholamine surge during image-guided ablation of metastases to the adrenal gland. MATERIALS AND METHODS: Between 2001 and 2014, 57 patients (39 men, 18 women; mean age, 65 y ± 10; age range, 41-81 y) at two academic medical centers underwent ablation of 64 metastatic adrenal tumors from renal cell carcinoma (n = 27), lung cancer (n = 23), melanoma (n = 4), colorectal cancer (n = 3), and other tumors (n = 7)...
March 2016: Journal of Vascular and Interventional Radiology: JVIR
Carlo Magno, Giuseppe Mucciardi, Alessandro Galì, Rosa Pappalardo, Francesco Lembo, Giuseppina Anastasi, Salvatore Butticè, Giorgio Ascenti, Franco Lugnani
OBJECTIVES: Locally advanced prostate cancer may cause several complications such as haematuria, bladder outlet obstruction, and renal failure due to the ureteral obstruction. Various treatments have been suggested, including radiotherapy, antifibrinolytics, bladder irrigation with alum solution, transurethral surgery and angioembolization, none of which have proven effectiveness. In the last years cryoablation has become a valid therapeutic option for prostate cancer. In our experience we used this 'new' technique as haemostatic therapy...
October 2015: Therapeutic Advances in Urology
Matthew J Maurice, Hui Zhu, Jonathan E Kiechle, Simon P Kim, Robert Abouassaly
OBJECTIVE: To describe recent temporal trends in biopsy use for renal cell carcinoma and to identify factors associated with biopsy. MATERIALS AND METHODS: Renal cell carcinoma diagnoses from 2003 to 2011 were identified using the National Cancer Data Base. Cases were classified by traditional (clinical stage T4, N1, or M1, or history of other malignancies) or expanded biopsy indications. Time trends were plotted, and multivariate analysis was performed to identify factors associated with biopsy...
November 2015: Urology
M Chodez, G Fiard, V Arnoux, J-L Descotes, J-A Long
OBJECTIVE AND METHOD: To focus on indications and results of ablative treatments (cyoablation, radiofrequency) for small renal masses, a bibliographic research was conducted in MedLine database using terms of "ablative treatment", "cryotherapy", "radiofrequency", "kidney cancer", "renal cell carcinoma". Sixty-four articles were selected. RESULTS: Carcinologic outcomes seem to be better with cryoablation than with radiofrequency. Available results have to be balanced according to surgical approach, teams' experience and duration of follow-up...
July 2015: Progrès en Urologie
Peter A Caputo, Daniel Ramirez, Homayoun Zargar, Oktay Akca, Hiury Silva Andrade, Charles O'Malley, Erick M Remer, Jihad H Kaouk
PURPOSE: With the incidence of renal cell carcinoma on the rise treatment options for the small renal mass have broadened. Cryoablation is increasingly used as a therapeutic option for renal tumors in select cases. However, studies with long-term oncologic outcomes are sparse. We evaluated the long-term oncologic outcomes of laparoscopic renal mass cryoablation. MATERIALS AND METHODS: We reviewed our laparoscopic cryoablation database for patients treated with laparoscopic cryoablation from October 1997 to February 2005...
October 2015: Journal of Urology
Thomas D Atwell, Jay J Vlaminck, Stephen A Boorjian, Anil N Kurup, Matthew R Callstrom, Adam J Weisbrod, Christine M Lohse, William R Hartman, Andrew H Stockland, Bradley C Leibovich, Grant D Schmit, Robert H Thompson
PURPOSE: To describe the technical methods, safety, and local tumor control rate associated with percutaneous cryoablation of stage T1b renal cell carcinoma (RCC). MATERIALS AND METHODS: A retrospective review of a percutaneous renal ablation registry was used to identify 46 patients with a total of 46 biopsy-proven RCC lesions measuring 4.1-7.0 cm treated with cryoablation between 2003 and 2011. The main outcome parameters investigated were adjunctive maneuvers, complications, and local tumor progression, and cancer-specific survival rates...
June 2015: Journal of Vascular and Interventional Radiology: JVIR
P V Glybochko, Iu G Aliaev, A V Amosov, D V Enikeev, D V Chinenov, I S Lumpov, A A Vorob'ev
Modern science opens up new potentials for the effective treatment of complex diseases using minimally invasive techniques. One of the obvious achievements of recent years is cryoablation - technology of local freezing of tissues, allowing to create a precision zone of tumor cell death in renal cancer and prostate cancer. The literature review presents historical information, highlighting the main stages in the development of cryosurgery since the XIX century. The analysis of domestic and foreign literature has shown that in urological practice cryoablation has been widely used...
November 2014: Urologii︠a︡
Hyung Keun Kim, Jong Hyun Pyun, Jae Yoon Kim, Seung Bin Kim, Seok Cho, Sung Gu Kang, Jeong Gu Lee, Je Jong Kim, Jun Cheon, Seok Ho Kang
PURPOSE: To evaluate the perioperative, functional, and oncological outcomes of renal cryoablation (RC) of small renal masses (SRMs) performed in Korea University Hospital. MATERIALS AND METHODS: We reviewed an Institutional Review Board-approved database of 70 patients who underwent RC and were followed up for a minimum of 3 months by a single surgeon in Korea University Hospital from August 2007 to May 2014. Among these patients, 68 patients (79 renal masses) were enrolled in our research...
February 2015: Korean Journal of Urology
Andrew J Miller, A Nicholas Kurup, Grant D Schmit, Adam J Weisbrod, Stephen A Boorjian, R Houston Thompson, Christine M Lohse, Darryl J Kor, Matthew R Callstrom, Thomas D Atwell
PURPOSE: To evaluate outcomes of percutaneous ablation of small renal tumors in the elderly population. PATIENTS AND METHODS: Using our tumor ablation database, we searched for percutaneous ablation procedures for clinical T1a renal masses in octogenarians and nonagenarians between June 2001 and May 2012. Altogether, 105 tumors from 99 procedures among 95 patients (mean age 84.0±3.0 years, range 80-92) were identified. Oncologic outcomes and major complications were evaluated...
June 2015: Journal of Endourology
Alessandro Larcher, Nicola Fossati, Francesco Mistretta, Giovanni Lughezzani, Giuliana Lista, Paolo Dell'Oglio, Alberto Abrate, Maxine Sun, Pierre Karakiewicz, Nazareno Suardi, Massimo Lazzeri, Francesco Montorsi, Giorgio Guazzoni, Nicolò Buffi
INTRODUCTION: Data regarding long-term oncologic outcomes of laparoscopic renal cryoablation (LRC) as first treatment for small renal masses (SRMs) are lacking. We hypothesized that LRC might provide an effective long-term cancer control in patients with a single cT1a SRM without a previous history of renal cell carcinoma (RCC). MATERIALS AND METHODS: The study design was a retrospective analysis of 174 consecutive patients who received LRC as first treatment for a single computed tomography or magnetic resonance imaging contrast-enhancing cT1a SRM between 2000 and 2013...
January 2015: Urologic Oncology
Scott Johnson, Khanh N Pham, William See, Frank P Begun, Peter Langenstroer
OBJECTIVE: To report the long-term oncologic outcomes of laparoscopic cryoablation for clinical stage T1 renal masses at the Medical College of Wisconsin. MATERIALS AND METHODS: A retrospective chart review was performed evaluating patients who underwent laparoscopic cryoablation for renal masses at the Medical College of Wisconsin between February 2000 and October 2009. RESULTS: A total of 171 renal masses in 144 patients were treated by laparoscopic cryoablation during the study period...
September 2014: Urology
Marleen J Ter Avest, Romane M Schook, Lyan G Koudstaal, Katrien Grünberg, Marinus A Paul, Egbert F Smit, Pieter E Postmus
BACKGROUND: The finding of a renal mass on imaging is suggestive of metastatic non-small cell lung cancer in the presence of a lung tumor but can also have another origin. CASE REPORT: We describe the case of a patient diagnosed with stage IV lung cancer based on a renal metastasis. A second opinion including review of histopathological data and additional imaging followed by lung surgery and cryoablation of the kidney lesion revealed two tumors of different origins, non-small cell lung cancer and a renal cell carcinoma...
January 2014: Case Reports in Oncology
Guglielmo Zeccolini, Dario Del Biondo, Calogero Cicero, Andrea Casarin, Alessandro Guarise, Antonio Celia
INTRODUCTION: Percutaneous ablation in the kidney is now performed as a standard therapeutic nephron-sparing option in patients who are poor candidates for resection. Its increasing use has been largely prompted by the rising incidental detection of renal cell carcinomas with cross-sectional imaging and the need to preserve renal function in patients with comorbid conditions, multiple renal cell carcinomas, and/or heritable renal cancer syndromes. To date, clinical studies indicate that cryoablation is an effective therapy with acceptable short- to intermediate-term outcomes and with a low risk in the appropriate setting...
January 2014: Urologia
Christos S Georgiades, Ron Rodriguez
PURPOSE: Percutaneous cryoablation is gaining in popularity as a viable treatment option for renal cell carcinoma (RCC). We present the 5-year oncologic outcomes of a prospective trial. METHODS: Over a 5-year period, we treated 134 consecutive patients with biopsy-proven RCC with CT-guided percutaneous cryoablation. All were treated while under conscious sedation. Technical objective was for the ice ball to cover the lesion plus a 5-mm margin. Hydro- or air dissection was utilized to aid in technical success as needed...
December 2014: Cardiovascular and Interventional Radiology
Youssef S Tanagho, Sam B Bhayani, Eric H Kim, R Sherburne Figenshau
BACKGROUND AND PURPOSE: American Urological Association guidelines endorse partial nephrectomy as the preferred treatment for patients with small renal masses, while considering patients with significant comorbidities potential candidates for ablative therapy. We compared perioperative, renal functional, and oncologic outcomes of renal cryoablation and robot-assisted partial nephrectomy (RAPN) based on our long-term institutional experience. PATIENTS AND METHODS: A retrospective review evaluated 267 patients who underwent laparoscopic or percutaneous cryoablation (July 2000-June 2011) and 233 patients who underwent RAPN (June 2007-September 2012) for enhancing renal masses at Washington University...
December 2013: Journal of Endourology
Youssef S Tanagho, Sam Bhayani, Eric H Kim, Robert S Figenshau
Background and Purpose: AUA guidelines endorse partial nephrectomy as the preferred treatment for small renal masses, while considering patients with significant comorbidities potential candidates for ablative therapy. We compared perioperative, renal functional, and oncological outcomes of renal cryoablation and robot-assisted partial nephrectomy (RAPN) based on our long-term institutional experience. Materials and Methods: A retrospective review evaluated 267 patients who underwent laparoscopic or percutaneous cryoablation (7/2000-6/2011) and 233 patients who underwent RAPN (6/2007-9/2012) for enhancing renal masses at Washington University...
October 31, 2013: Journal of Endourology
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