keyword
MENU ▼
Read by QxMD icon Read
search

bioactive compounds

keyword
https://www.readbyqxmd.com/read/28226282/systematic-identification-of-flavonols-flavonol-glycosides-triterpene-and-siraitic-acid-glycosides-from-siraitia-grosvenorii-using-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-combined-with-a-screening-strategy
#1
Zhi-Xing Qing, Huan Zhao, Qi Tang, Chang-Ming Mo, Peng Huang, Pi Cheng, Peng Yang, Xue-Yi Yang, Xiu-Bin Liu, Ya-Jie Zheng, Jian-Guo Zeng
The fruits of Siraitia grosvenorii are considered to be health-promoting because of the diversity of their bioactive ingredients. In the present study, a screening method, using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) combined with a screening strategy, has been established. The technology was used to systematically screening the targeted metabolites, primarily from the complex matrix of S. grosvenorii. The compounds were then identified by their exact masses and characteristic fragment ions, in comparison with the fragmentation behaviors of 19 references...
February 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28226233/chemical-genetic-dissection-of-membrane-trafficking
#2
Lorena Norambuena, Ricardo Tejos
The plant endomembrane system is an extensively connected functional unit for exchanging material between compartments. Secretory and endocytic pathways allow dynamic trafficking of proteins, lipids, and other molecules, regulating a myriad of biological processes. Chemical genetics-the use of compounds to perturb biological processes in a fast, tunable, and transient manner-provides elegant tools for investigating this system. Here, we review how chemical genetics has helped to elucidate different aspects of membrane trafficking...
February 13, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/28225766/marine-actinobacteria-as-a-source-of-compounds-for-phytopathogen-control-an-integrative-metabolic-profiling-bioactivity-and-taxonomical-approach
#3
Luz A Betancur, Sandra J Naranjo-Gaybor, Diana M Vinchira-Villarraga, Nubia C Moreno-Sarmiento, Luis A Maldonado, Zulma R Suarez-Moreno, Alejandro Acosta-González, Gillermo F Padilla-Gonzalez, Mónica Puyana, Leonardo Castellanos, Freddy A Ramos
Marine bacteria are considered as promising sources for the discovery of novel biologically active compounds. In this study, samples of sediment, invertebrate and algae were collected from the Providencia and Santa Catalina coral reef (Colombian Caribbean Sea) with the aim of isolating Actinobateria-like strain able to produce antimicrobial and quorum quenching compounds against pathogens. Several approaches were used to select actinobacterial isolates, obtaining 203 strains from all samples. According to their 16S rRNA gene sequencing, a total of 24 strains was classified within Actinobacteria represented by three genera: Streptomyces, Micromonospora, and Gordonia...
2017: PloS One
https://www.readbyqxmd.com/read/28225035/deep-sequencing-and-transcriptome-analyses-to-identify-genes-involved-in-secoiridoid-biosynthesis-in-the-tibetan-medicinal-plant-swertia-mussotii
#4
Yue Liu, Yi Wang, Fengxian Guo, Lin Zhan, Toni Mohr, Prisca Cheng, Naxin Huo, Ronghui Gu, Danning Pei, Jiaqing Sun, Li Tang, Chunlin Long, Luqi Huang, Yong Q Gu
Swertia mussotii Franch. is an important traditional Tibetan medicinal plant with pharmacological properties effective in the treatment of various ailments including hepatitis. Secoiridoids are the major bioactive compounds in S. mussotii. To better understand the secoiridoid biosynthesis pathway, we generated transcriptome sequences from the root, leaf, stem, and flower tissues, and performed de novo sequence assembly, yielding 98,613 unique transcripts with an N50 of 1,085 bp. Putative functions could be assigned to 35,029 transcripts (35...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224159/rice-bran-constituents-immunomodulatory-and-therapeutic-activities
#5
REVIEW
Ho-Young Park, Kwang-Won Lee, Hee-Don Choi
Rice bran, one of the most abundant and valuable byproducts produced during the rice milling process, is of steadily growing interest in recent years due to its potential health benefits. Evidence is rapidly accumulating for the beneficial effects of nutraceuticals. However, the potential benefits of rice bran are found in several of its bioactive ingredients including oils, polysaccharides, proteins, and micronutrients. In addition, a significant advantage of rice bran is that it contains more than 100 antioxidants and several categories of bioactive phytonutrients, such as polyphenols, phytosterols, tocotrienols, γ-oryzanol, B vitamins, minerals, and trace minerals...
February 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28223870/bioactivity-and-chemical-characterization-of-acalypha-fruticosa-forssk-growing-in-saudi-arabia
#6
Ghada Ahmed Fawzy, Areej Mohammad Al-Taweel, Shagufta Perveen, Shabana Iqrar Khan, Fatma Abdulaziz Al-Omary
Acalypha is an important genus of the Euphorbiaceae family. The genus is represented by five species in Saudi Arabia. Acalypha fruticosa Forssk. Fl. Aeg is traditionally used as a cure for stomachache, dyspepsia, rheumatism, dermatitis, and swellings of the body. The present study endeavors to provide a phytochemical and biological evaluation of the plant, with the aim of relating activity to constituting secondary metabolites in the plant. Column chromatographic separation of the methanol extract led to the isolation of four compounds namely 2-methyl-5,7-dihydroxychromone 5-O-β-d-glucopyranoside 1, acalyphin 2, apigenin 3 and kaempferol 3-O-rutinoside 4...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28223801/phytobioactive-compound-based-nanodelivery-systems-for-the-treatment-of-type-2-diabetes-mellitus-current-status
#7
REVIEW
Palanivel Ganesan, Palanisamy Arulselvan, Dong-Kug Choi
Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28223778/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-an-endophytic-streptomyces-suk10
#8
Noraziah Mohamad Zin, Mohd Shukri Baba, Abu Hassan Zainal-Abidin, Jalifah Latip, Noor Wini Mazlan, RuAngelie Edrada-Ebel
Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 μg kg(-1) body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28222858/bioprofiling-of-salicaceae-bud-extracts-through-high-performance-thin-layer-chromatography-hyphenated-to-biochemical-microbiological-and-chemical-detections
#9
Salim Hage, Gertrud E Morlock
The buds of poplars (Populus L.) and willows (Salix L.), both from the same family (Salicaceae Mirbel), are increasingly used in gemmotherapy and importantly contribute to the production of the physiologically active propolis by European bee Apis mellifera L. In order to study their phenolic profiles, polar extracts of buds from P. nigra L. were compared to those of P. alba L. and S. alba L. through high-performance thin-layer chromatography (HPTLC). Five chemotypical patterns were distinguished after derivatisation with the Natural Product reagent and confirmed by principal component analysis...
February 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28221784/development-of-a-biosensor-concept-to-detect-the-production-of-cluster-specific-secondary-metabolites
#10
Yi-Qian Sun, Tobias Busche, Christian Rückert, Constanze Paulus, Yuriy Rebets, Renata Novakova, Joern Kalinowski, Andriy Luzhetskyy, Jan Kormanec, Olga N Sekurova, Sergey B Zotchev
Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis gene clusters in Streptomyces was developed. Biosynthetic gene clusters for undecylprodigiosin and coelimycin in the genome of Streptomyces lividans TK24, which encoded TetR-like repressors and appeared to be almost "silent" based on the RNA-seq data were chosen for the proof-of-principle studies...
February 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28220202/enzyme-inhibitory-metabolites-from-endophytic-penicillium-citrinum-isolated-from-boswellia-sacra
#11
Sajid Ali, Abdul Latif Khan, Liaqat Ali, Tania Shamim Rizvi, Sumera Afzal Khan, Javid Hussain, Muhammad Hamayun, Ahmed Al-Harrasi
Fungal endophytes establish an important niche within the host plant through the secretion of chemical constituents. Isolation of bioactive metabolites could be a vital source for inhibiting the function of enzymes such as α-glucosidase and urease. The present study aimed to elucidate the potential of endophytes associated with Boswellia sacra through bioassay-guided isolation and identification of secondary metabolites with enzyme inhibitory ability. Endophytic fungal strains viz. Penicillium citrinum, P...
February 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28219046/synthesis-and-biological-evaluation-of-novel-pyrazolic-chalcone-derivatives-as-novel-hepatocellular-carcinoma-therapeutics
#12
Mohammed M A Hawash, Deniz Cansen Kahraman, Fikriye Eren, Rengul Cetin Atalay, Sultan Nacak Baytas
Despite having the second highest mortality associated with cancer, currently Sorafenib is the only FDA-approved chemotherapeutic agent available for liver cancer patients which can only improve survival for few months. In this study, various pyrazolic chalcone analogous compounds were synthesized and evaluated as potential chemotherapeutic agents for the treatment of hepatocellular carcinoma (HCC). Modifying the central pyrazole ring at the C(3)-position with different heteroaryl rings and substituting the C(4)-position of pyrazole with differently substituted chalcone moiety produced fouthy two variant compounds...
February 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28218912/engineering-fatty-acid-synthases-for-directed-polyketide-production
#13
Jan Gajewski, Floris Buelens, Sascha Serdjukow, Melanie Janßen, Niña Cortina, Helmut Grubmüller, Martin Grininger
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.
February 20, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28218718/an-efficient-synthesis-of-novel-bioactive-thiazolyl-phthalazinediones-under-ultrasound-irradiation
#14
Fatma S Elsharabasy, Sobhi M Gomha, Thoraya A Farghaly, Heba S A Elzahabi
Novel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for antifungal activity. The antimicrobial activity profile of the tested compounds showed some promising results. The potent activity of compounds 4d, 7b (117% zone inhibition) and 7c (105% zone inhibition) against Salmonella sp...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28218694/antibacterial%C3%A2-activities%C3%A2-of%C3%A2-bacteria%C3%A2-isolated%C3%A2-from%C3%A2-the%C3%A2-marine%C3%A2-sponges%C3%A2-isodictya%C3%A2-compressa%C3%A2-and%C3%A2-higginsia%C3%A2-bidentifera%C3%A2-collected%C3%A2-from%C3%A2-algoa%C3%A2-bay-%C3%A2-south%C3%A2-africa
#15
Relebohile Matthew Matobole, Leonardo Joaquim van Zyl, Shirley Parker-Nance, Michael T Davies-Coleman, Marla Trindade
Due to the rise in multi-drug resistant pathogens and other diseases, there is renewed interest in marine sponge endosymbionts as a rich source of natural products (NPs). The South African marine environment is rich in marine biota that remains largely unexplored and may represent an important source for the discovery of novel NPs. We first investigated the bacterial diversity associated with five South African marine sponges, whose microbial populations had not previously been investigated, and select the two sponges (Isodictya compressa and Higginsia bidentifera) with highest species richness to culture bacteria...
February 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28218675/briarane-diterpenoids-isolated-from-octocorals-between-2014-and-2016
#16
REVIEW
Yin-Di Su, Jui-Hsin Su, Tsong-Long Hwang, Zhi-Hong Wen, Jyh-Horng Sheu, Yang-Chang Wu, Ping-Jyun Sung
The structures, names, bioactivities, and references of 124 briarane-type natural products, including 66 new metabolites, isolated between 2014 and 2016 are summarized in this review article. All of the briarane diterpenoids mentioned in this review were isolated from octocorals, mainly from Briareum violacea, Dichotella gemmacea, Ellisella dollfusi, Junceella fragilis, Junceella gemmacea, and Pennatula aculeata. Some of these compounds exhibited potential biomedical activities, including anti-inflammatory activity, antibacterial activity, and cytotoxicity towards cancer cells...
February 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28218395/coffee-tea-and-melanoma-risk-findings-from-the-european-prospective-investigation-into-cancer-and-nutrition
#17
Saverio Caini, Giovanna Masala, Calogero Saieva, Marina Kvaskoff, Isabelle Savoye, Carlotta Sacerdote, Oskar Hemmingsson, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina E N Petersen, Francesca Romana Mancini, Marie-Christine Boutron-Ruault, Iris Cervenka, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Anna Floegel, Antonia Trichopoulou, Elisavet Valanou, Maria Kritikou, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, H Bas Bueno-de-Mesquita, Petra H Peeters, Marit B Veierød, Reza Ghiasvand, Marko Lukic, José Ramón Quirós, Maria-Dolores Chirlaque, Eva Ardanaz, Elena Salamanca Fernández, Nerea Larrañaga, Raul Zamora-Ros, Lena Maria Nilsson, Ingrid Ljuslinder, Karin Jirström, Emily Sonestedt, Timothy J Key, Nick Wareham, Kay-Tee Khaw, Marc Gunter, Inge Huybrechts, Neil Murphy, Konstantinos K Tsilidis, Elisabete Weiderpass, Domenico Palli
In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma, however epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multi-centre prospective study that enrolled over 500,000 participants aged 25-70 years from ten European countries in 1992-2000...
February 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28217983/extraction-and-separation-of-lactate-dehydrogenase-inhibitors-from-poria-cocos-schw-wolf-based-on-a-hyphenated-technique-and-in-vitro-methods
#18
Sainan Li, Jianxu Zhang, Senlin Li, Chunming Liu, Shu Liu, Zhiqiang Liu
Stroke is one of the most common diseases worldwide. Lactate dehydrogenase inhibitors are widely used in the treatment of ischemic stroke, with natural products considered a promising source of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening and identification of lactate dehydrogenase inhibitors from Poria cocos. Five lactate dehydrogenase inhibitors were selected: dehydropachymic acid, pachymic acid, dehydrotrametenolic acid, trametenolic acid, and eburicoic acid...
February 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28217929/phytochemical-characterization-antibacterial-acetylcholinesterase-inhibitory-and-cytotoxic-properties-of-cryptostephanus-vansonii-an-endemic-amaryllid
#19
Mack Moyo, Adeyemi O Aremu, Jude C Chukwujekwu, Jiri Gruz, Jiri Skorepa, Karel Doležal, Cuthbert A T Katsvanga, Johannes Van Staden
Cryptostephanus vansonii I. Verd., an endemic Amaryllidaceae species from Zimbabwe, was evaluated for its acetylcholinesterase (AChE) inhibitory and cytotoxicity properties using Ellman's colorimetric method and the tetrazolium-based colorimetric assay against Vero monkey kidney cells, respectively. The plant extracts were also evaluated for their antibacterial activity against five bacteria. Furthermore, phytochemical profiles of the extracts were determined using ultra-high performance liquid chromatography coupled with tandem mass spectrometry analysis...
February 20, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28217823/novel-insight-from-computational-virtual-screening-depict-the-binding-potential-of-selected-phytotherapeutics-against-probable-drug-targets-of-clostridium-difficile
#20
Suman Kamath, Sinosh Skariyachan
This study explores computational screening and molecular docking approaches to screen novel herbal therapeutics against probable drug targets of Clostridium difficile. The essential genes were predicted by comparative genome analysis of C. difficile and best homologous organisms using BLAST search at database of essential genes (DEG). The functions of these genes in various metabolic pathways were predicted and some of these genes were considered as potential targets. Three major proteins were selected as putative targets, namely permease IIC component, ABC transporter and histidine kinase...
February 20, 2017: Interdisciplinary Sciences, Computational Life Sciences
keyword
keyword
106736
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"