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https://www.readbyqxmd.com/read/29166560/analytical-challenges-and-recent-advances-in-mass-spectrometry-based-lipidomics
#1
Yepy Hardi Rustam, Gavin Edmund Reid
Although no internationally accepted consensus definition exists, lipids can be broadly defined as "fatty acids and their derivatives, and substances related biosynthetically or functionally to these compounds". Lipids play critical roles as (i) the major structural components of biological membranes, and as functional and regulatory components of membrane protein signaling, (ii) bioactive intra- and inter-cellular signaling molecules, and (iii) energy storage molecules for the maintenance of energy homeostasis...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29166547/chemical-metabolome-assay-by-high-resolution-orbitrap-mass-spectrometry-and-assessment-of-associated-antitumoral-activity-of-actinocephalus-divaricatus
#2
Ana C Zanatta, Angela Mari, Milena Masullo, Iracilda Zeppone Carlos, Wagner Vilegas, Sonia Piacente, Lourdes Campaner Dos Santos
RATIONALE: Actinocephalus divaricatus (Eriocaulaceae) is an important source of income for the rural communities as it is sold as an ornamental plant. To date, no investigation has been conducted concerning the chemical composition and biological studies of the aerial parts of A. divaricatus. METHODS: The methanolic extract of the aerial parts of this species was chemically characterized. We applied an analytical dereplication approach based on Liquid Chromatography coupled to High Resolution Orbitrap Mass Spectrometry in order to develop, identify and define rapidly the metabolite fingerprint of the aerial parts of A...
November 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29166533/potential-effects-of-fungicide-and-algaecide-extracts-of-annona-glabra-l-annonaceae-on-the-microalgae-raphidocelis-subcapitata-and-on-the-oomycete-pythium
#3
Giseli S Rocha, Reginaldo S Matsumoto, Ana Teresa Lombardi, Maria Inês S Lima
Annona glabra L. is a semi-deciduous tree that contains several active substances, including secondary metabolites, with antifungal activity. Phytopathogenic strains of the genus Pythium cause billion dollar losses all over the world on natural and crop species. Searching for eco-friendly algaecides and fungicides, we analyzed the effects of acetone extracts of A. glabra leaves on the algae Rhaphidocelis subcapitata (Korshikov) and on the oomycete Pythium aphanidermatum (Edson). We evaluated ten extract concentrations for each organism - 0 to 400 mg L-1 for algae and 0-1000 µg disc1 for oomycete...
2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29165404/benefits-of-nut-consumption-on-insulin-resistance-and-cardiovascular-risk-factors-multiple-potential-mechanisms-of-actions
#4
REVIEW
Yoona Kim, Jennifer B Keogh, Peter M Clifton
Epidemiological and clinical studies have indicated that nut consumption could be a healthy dietary strategy to prevent and treat type 2 diabetes (T2DM) and related cardiovascular disease (CVD). The objective of this review is to examine the potential mechanisms of action of nuts addressing effects on glycemic control, weight management, energy balance, appetite, gut microbiota modification, lipid metabolism, oxidative stress, inflammation, endothelial function and blood pressure with a focus on data from both animal and human studies...
November 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29165339/chemical-compounds-and-bioactivity-of-aqueous-extracts-of-alibertia-spp-in-the-control-of-plutella-xylostella-l-lepidoptera-plutellidae
#5
Lucas L S Peres, Ana I Sobreiro, Irys F S Couto, Rosicléia M Silva, Fabricio F Pereira, Silvia C Heredia-Vieira, Claudia A L Cardoso, Munir Mauad, Silvana P Q Scalon, Sandra S Verza, Rosilda M Mussury
Successive applications of insecticides to control Plutella xylostella L. (Lepidoptera: Plutellidae) have resulted in the emergence of resistant populations of this insect. A novel control measure for this target insect could be the use of botanical insecticides derived from plant tissues. Hence, we experimentally tested aqueous extracts of Alibertia edulis (Rich.), Alibertia intermedia (Mart.), and Alibertia sessilis (Vell.) K. Schum. found in the Brazilian savannah in order to investigate their potential to disrupt the life cycle of P...
November 22, 2017: Insects
https://www.readbyqxmd.com/read/29165163/the-potential-protective-effect-of-commelina-nudiflora-l-against-carbon-tetrachloride-ccl4-induced-hepatotoxicity-in-rats-mediated-by-suppression-of-oxidative-stress-and-inflammation
#6
Muhammad Dawood Shah, Urban J A D'Souza, Mohammad Iqbal
BACKGROUND: This study aims to assess the hepatoprotective potential of Commelina nudiflora against CCl4-induced hepatic injury in rats. METHOD: Antioxidant activities were determined. Phytochemical analysis was performed by gas chromatography mass spectrometry (GCMS). In the in vivo study, Sprague Dawley rats were pretreated with C. nudiflora (150, 300, and 450 mg kg body weight (b.wt.)) once daily for 14 days followed by two doses of CCl4 (1 ml/kg b.wt.). After 2 weeks, the rats were sacrificed and hepatoprotective analysis was performed...
September 11, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165050/functional-properties-of-anti-inflammatory-substances-from-quercetin-treated-bifidobacterium-adolescentis
#7
Kyuichi Kawabata, Nobuyuki Baba, Taiken Sakano, Yoshimitsu Hamano, Shu Taira, Akira Tamura, Seigo Baba, Midori Natsume, Takeshi Ishii, Shigeru Murakami, Hajime Ohigashi
The genus Bifidobacterium is well known to have beneficial health effects. We discovered that quercetin and related polyphenols enhanced the secretion of anti-inflammatory substances by Bifidobacterium adolescentis. This study investigated characteristics of the anti-inflammatory substances secreted by B. adolescentis. The culture supernatant of B. adolescentis with quercetin reduced the levels of inflammatory mediators in activated macrophages. Spontaneous quercetin degradant failed to increase anti-inflammatory activity, while the enhancement of anti-inflammatory activity by quercetin was sustained after washout of quercetin...
November 22, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29164634/testing-the-limits-of-model-membrane-simulations-bilayer-composition-and-pressure-scaling
#8
Nikoleta Ivanova, Anela Ivanova
Studying transfer of bioactive compounds across cell membranes by simulations attracts growing attention. To perform such calculations accurately, it is necessary to verify the validity of computational protocols established for description of unperturbed lipid bilayers also with translocating substances present. The current work reports the results from 1 μs long atomistic molecular dynamics simulations of two types of model plasma membranes-one built of a single phospholipid (DPPC) and one constructed of four types of phospholipids-in the presence of a drug-peptide complex experimentally known to cross cell membranes...
November 21, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29164416/high-throughput-and-direct-measurement-of-androgen-levels-using-turbulent-flow-chromatography-liquid-chromatography-triple-quadrupole-mass-spectrometry-tfc-lc-tqms-to-discover-chemicals-that-modulate-dihydrotestosterone-production-in-human-prostate-cancer-cells
#9
Kyungsu Kang, Lei Peng, Yu-Jin Jung, Joo Yeon Kim, Eun Ha Lee, Hee Ju Lee, Sang Min Kim, Sang Hyun Sung, Cheol-Ho Pan, Yongsoo Choi
OBJECTIVES: To develop a high-throughput screening system to measure the conversion of testosterone to dihydrotestosterone (DHT) in cultured human prostate cancer cells using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS). RESULTS: After optimizing the cell reaction system, this method demonstrated a screening capability of 103 samples, including 78 single compounds and 25 extracts, in less than 12 h without manual sample preparation...
November 21, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29164127/antidiabetic-effects-of-aronia-melanocarpa-and-its-other-therapeutic-properties
#10
REVIEW
Ines Banjari, Andreja Misir, Katarina Šavikin, Stela Jokić, Maja Molnar, H K S De Zoysa, Viduranga Y Waisundara
Diabetes is a global pandemic which warrants urgent attention due to its rising prevalence and economic burden. Thus, many alternative therapies are being researched for antidiabetic properties, given the inefficacy of current medicinal treatments. From this perspective, Aronia melanocarpa or black chokeberry has been investigated for its therapeutic properties in many studies, especially for its ability to combat hyperglycemia-induced oxidative stress and the macrovascular complications of diabetes including cardiovascular disease...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29163609/selenium-biofortification-in-fragaria-%C3%A3-ananassa-implications-on-strawberry-fruits-quality-content-of-bioactive-health-beneficial-compounds-and-metabolomic-profile
#11
Tanja Mimmo, Raphael Tiziani, Fabio Valentinuzzi, Luigi Lucini, Carlo Nicoletto, Paolo Sambo, Matteo Scampicchio, Youry Pii, Stefano Cesco
Selenium (Se) is an essential nutrient for humans, due to its antioxidant properties, whereas, to date, its essentiality to plants still remains to be demonstrated. Nevertheless, if added to the cultivation substrate, plants growth resulted enhanced. However, the concentration of Se in agricultural soils is very variable, ranging from 0.01 mg kg(-1) up to 10 mg kg(-1) in seleniferous areas. Therefore several studies have been performed aimed at bio-fortifying crops with Se and the approaches exploited were mainly based on the application of Se fertilizers...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163380/focused-review-cytotoxic-and-antioxidant-potentials-of-mangrove-derived-streptomyces
#12
REVIEW
Hooi-Leng Ser, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Kok-Gan Chan, Acharaporn Duangjai, Surasak Saokaew, Priyia Pusparajah, Nurul-Syakima Ab Mutalib, Tahir Mehmood Khan, Bey-Hing Goh, Learn-Han Lee
Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162708/lactobacillus-acidophilus-metabolizes-dietary-plant-glucosides-and-externalizes-their-bioactive-phytochemicals
#13
Mia C Theilmann, Yong Jun Goh, Kristian Fog Nielsen, Todd R Klaenhammer, Rodolphe Barrangou, Maher Abou Hachem
Therapeutically active glycosylated phytochemicals are ubiquitous in the human diet. The human gut microbiota (HGM) modulates the bioactivities of these compounds, which consequently affect host physiology and microbiota composition. Despite a significant impact on human health, the key players and the underpinning mechanisms of this interplay remain uncharacterized. Here, we demonstrate the growth of Lactobacillus acidophilus on mono- and diglucosyl dietary plant glycosides (PGs) possessing small aromatic aglycones...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29162539/modulation-of-diverse-oncogenic-transcription-factors-by-thymoquinone-an-essential-oil-compound-isolated-from-the-seeds-of-nigella-sativa-linn
#14
REVIEW
Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Lingzhi Wang, Boon Cher Goh, Kwang Seok Ahn, Anupam Bishayee, Gautam Sethi
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have promising effects against a variety of inflammatory diseases and cancer. Cancer development is a multistep process where normal cells acquire qualities that enable the cells to proliferate continuously and migrate to distant sites in the human body. Drugs that interfere with this process are considered potential anti-cancer therapeutics, which may ultimately result in their clinical usage...
November 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29162451/hydrostatic-pressure-incubation-affects-barrier-properties-of-mammary-epithelial-cell-monolayers-in-vitro
#15
Katharina S Mießler, Alexander G Markov, Salah Amasheh
During lactation, accumulation of milk in mammary glands (MG) causes hydrostatic pressure (HP) and concentration of bioactive compounds. Previously, a changed expression of tight junction (TJ) proteins was observed in mice MGs by accumulation of milk, in vivo. The TJ primarily determines the integrity of the MG epithelium. The present study questioned whether HP alone can affect the TJ in a mammary epithelial cell model, in vitro. Therefore, monolayers of HC11, a mammary epithelial cell line, were mounted into modified Ussing chambers and incubated with 10 kPa bilateral HP for 4 h...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29161815/bioactive-compounds-of-edible-purple-laver-porphyra-sp-nori
#16
Tomohiro Bito, Fei Teng, Fumio Watanabe
Porphyra sp. (nori) is widely cultivated as an important marine crop. Dried nori contains numerous nutrients including vitamin B12, which is the only vitamin absent from plant-derived food sources. Vegetarian diets are relatively low in iron and vitamin B12; depletion of both causes severe anemia. Nori also contains considerable amounts of iron compared with other plant-derived foods and eicosapentaenoic acid, which is an important fatty acid found in fish oils. In nori, there are also many bioactive compounds exhibiting various pharmacological activities, such as immunomodulation, anticancer, antihyperlipidemic, and antioxidative activities...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161814/changes-in-aromatic-profile-sugars-and-bioactive-compounds-when-purple-garlic-is-transformed-into-black-garlic
#17
Lucia Martinez-Casas, Maria Lage-Yusty, Julia Lopez-Hernandez
Black garlic is a processed garlic product obtained from the treatment of fresh garlic (Allium sativum L.) under high temperature and high humidity conditions, which leads to modifications in colour, taste and texture. To clarify the physicochemical changes that occur during the thermal process, this study aimed to evaluate and compare the antioxidant activity and other compounds between purple garlic ecotype "Purple from Las Pedroñeras", and its black garlic derivative. Our results showed numerous differences between both, since black garlic presented a significant divergence in the volatile profile, a decreased amount of ascorbic acid, an increment in sugar and polyphenol contents, a greater antioxidant capacity and a different composition of phenolic acids and flavonoids...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161429/crosstalk-between-the-microbiome-and-epigenome-messages-from-bugs
#18
Yufeng Qin, Paul A Wade
Mammals exist in a complicated symbiotic relationship with their gut microbiome, which is postulated to have broad impacts on host health and disease. As omics-based technologies have matured, the potential mechanisms by which the microbiome affects host physiology are being addressed. The gut microbiome, which provides environmental cues, can modify host cell responses to stimuli through alterations in the host epigenome and, ultimately, gene expression. Increasing evidence highlights microbial generation of bioactive compounds that impact the transcriptional machinery in host cells...
November 17, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29160894/chlorogenic-acids-and-the-acyl-quinic-acids-discovery-biosynthesis-bioavailability-and-bioactivity
#19
REVIEW
Michael N Clifford, Indu B Jaganath, Iziar A Ludwig, Alan Crozier
Covering: 2000 up to late 2017This review is focussed upon the acyl-quinic acids, the most studied group within the ca. 400 chlorogenic acids so far reported. The acyl-quinic acids, the first of which was characterised in 1846, are a diverse group of plant-derived compounds produced principally through esterification of an hydroxycinnamic acid and 1l-(-)-quinic acid. Topics addressed in this review include the confusing nomenclature, quantification and characterisation by NMR and MS, biosynthesis and role in planta, and the occurrence of acyl-quinic acids in coffee, their transformation during roasting and delivery to the beverage...
November 21, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/29160857/synergistic-effects-of-danshen-salvia-miltiorrhizae-radix-et-rhizoma-and-sanqi-notoginseng-radix-et-rhizoma-combination-in-angiogenesis-behavior-in-eahy-926-cells
#20
Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chunguang Li, Alan Bensoussan, Kelvin Chan
Background: This study investigated the combination effects of the Danshen and Sanqi herb pair on angiogenesis in vitro. Methods: Nine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their angiogenic effects in the human vascular endothelial EAhy 926 cell line via cell proliferation, cell migration and tube formation activities against the damage to the cells exerted by DL-homocysteine (Hcy) and adenosine (Ado). The type of interaction (synergistic, antagonistic, additive) between Danshen and Sanqi was analyzed using combination index (CI) and isobologram models...
November 21, 2017: Medicines (Basel, Switzerland)
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