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https://www.readbyqxmd.com/read/28107573/diversity-and-bioprospecting-of-actinomycete-endophytes-from-the-medicinal-plants
#1
REVIEW
Nalini Monnanda Somaiah, Harishchandra Sripathy Prakash
The endophytic actinomycetes constitute one of the fascinating group of microorganisms associated with a wide range of plant species. The diversity of actinomycetes in plants and their tissue parts is a matter of debate as no consensus are derived between individual studies. Nevertheless, their diversity correlates with the occurrence in plant species harbored in unique regions of biologically diverse areas called 'hot spots'. Recent advances in the isolation techniques have facilitated the isolation of rare taxa from these environments...
January 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28106745/recent-advances-in-phospholipids-from-colostrum-milk-and-dairy-by-products
#2
REVIEW
Vito Verardo, Ana Maria Gómez-Caravaca, David Arráez-Román, Kasper Hettinga
Milk is one of the most important foods for mammals, because it is the first form of feed providing energy, nutrients and immunological factors. In the last few years, milk lipids have attracted the attention of researchers due to the presence of several bioactive components in the lipid fraction. The lipid fraction of milk and dairy products contains several components of nutritional significance, such as ω-3 and ω-6 polyunsaturated fatty acids, CLA, short chain fatty acids, gangliosides and phospholipids...
January 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106710/banana-passion-fruit-passiflora-mollissima-kunth-l-h-bailey-microencapsulation-phytochemical-composition-and-antioxidant-capacity
#3
Almudena García-Ruiz, Amadeo Girones-Vilaplana, Paola León, Diego A Moreno, Carla M Stinco, Antonio J Meléndez-Martínez, Jenny Ruales
Passiflora mollissima (Kunth) L.H. Bailey is an exotic fruit native to South America, known as taxo in Ecuador. This paper characterizes its flavonoid and carotenoid composition and antioxidant capacity and evaluates the effect of the spray-drying process on its phytochemical composition and antioxidant capacity. A total of 18 flavonoid compounds, nine proanthocyanidins and nine flavan-3-ol monomers, were identified and quantified. Glycosides of (epi)-afzelechin stood out as the most abundant flavonoid. Three carotenoids were identified, with β-carotene having the highest concentration...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106249/targeted-forcing-improves-quality-nutritional-and-health-value-of-sweet-cherry-fruit
#4
Verena Overbeck, Michaela Schmitz, Michael Blanke
BACKGROUND: Trade and consumers alike require premium quality cherries with high nutritional and health values preferably of local origin. While early fruit imports cannot supply such fruit, a new technology of forcing cherry emerged for an early local supply by covering the crop in spring. In the apparent scarcity of data on the resulting fruit quality, fruit characteristics of forced cherries were compared with those without cover RESULTS: Size and weight of forced cherry fruit were successfully increased by 6-14%...
January 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28106217/flavanol-concentrations-do-not-predict-dipeptidyl-peptidase-iv-inhibitory-activities-of-four-cocoas-with-different-processing-histories
#5
Caroline M Ryan, Weslie Khoo, Amanda C Stewart, Sean F O'Keefe, Joshua D Lambert, Andrew P Neilson
Cocoa and its constituent bioactives (particularly flavanols) have reported anti-diabetic and anti-obesity activities. One potential mechanism of action is inhibition of dipeptidyl peptidase-IV (DPP4), the enzyme that inactivates incretin hormones such as glucagon-like peptide-1 and gastric inhibitory peptide. The objective of this study was to determine the DPP4 inhibitory activities of cocoas with different processing histories, and identify processing factors and bioactive compounds that predict DPP4 inhibition...
January 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28106210/multi-step-continuous-flow-synthesis
#6
Joshua Britton, Colin L Raston
Organic chemistry is continually evolving to improve the syntheses of value added and bioactive compounds. Through this progression, a concomitant advancement in laboratory technology has occurred. Many researchers now choose to mediate transformations in continuous-flow systems given the many benefits over round bottom flasks. Furthermore, reaction scale up is often less problematic as this is addressed at the inception of the science. Although single-step transformations in continuous-flow systems are common, multi-step transformations are more valuable...
January 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28105197/mitochondria-targeting-nano-agents-in-cancer-therapeutics
#7
Xiao-Ying Zhang, Pei-Ying Zhang
Mitochondria have emerged as noteworthy therapeutic targets as their physiological functions are often altered in pathological conditions such as cancer. The electronic databases of MEDLINE, EMBASE and PubMed were searched for recent studies reporting the importance of mitochondria targeting nanoagents in cancer therapeutics. The concluding remarks of the above papers mostly confirmed the growing potential of these novel nanoagents in the area of anticancer research. Furthermore, numerous studies demonstrated the immense potential of nanocarriers in delivering mitochondria-acting compounds to their target site...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104971/anti-inflammatory-and-anti-nociceptive-activities-of-stem-bark-extracts-and-fractions-of-carpolobia-lutea-polygalaceae
#8
Lucky Legbosi Nwidu, Blessing Airhihen, Augustine Ahmadu
BACKGROUND: In Niger Delta, ethnomedicine hydroalcoholic extract of Carpolobia lutea (CL) (Polygalaceae) is used to relieve inflammatory pains. OBJECTIVES: The purpose of this study is to evaluate the anti-inflammatory and antinociceptive effects of ethanolic stem extract (ESE) and to fractionate the ESE for the elucidation of bioactive molecules. MATERIALS AND METHODS: The antinociceptive effects for ESE were tested against two noxious stimuli; chemical (acetic acid-induced writhing and formalin-induced pain) and thermal (hot plate) stimuli...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28103773/agaricus-blazei-bioactive-compounds-and-their-effects-on-human-health-benefits-and-controversies
#9
Aline Cristine da Silva de Souza, Vanesa Gesser Correa, Geferson de Almeida Gonçalves, Andréia Assunção Soares, Adelar Bracht, Rosane Marina Peralta
BACKGROUND: The mushroom Agaricus blazei has evoked considerable scientific and practical interest in several fields, especially those linked to its medicinal properties. This review aims to summarize and evaluate the past decade findings related to nutritional and therapeutic uses of A. blazei, with especial emphasis on the most recent discoveries regarding its chemical composition and clinical investigations. METHODS: The specialized literature was searched for basic and clinical studies...
January 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28103771/structure-based-study-of-natural-products-with-anti-schistosoma-activity
#10
Ibezim Akachukwu, Olujide Oludayo Olubiyi, Ata Kosisochukwu, Mbah Chika John, Nwodo Ngozi Justina
: Background Schistosomiasis is a parasitic protozoal disease caused by flatworms of the genus Schistosoma. Although the disease threatens millions of lives, it is still at the top list of neglected tropical diseases and praziquantel, the only common schistosocidal drug in use, has records of decreasing efficiency and cases of resistance. Also, reports revealed that people in the rural areas, who are most affected, rely mostly on traditional herbal medicines because of limited access to modern healthcare...
January 19, 2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/28103302/crude-extracts-flavokawain-b-and-alpinetin-compounds-from-the-rhizome-of-alpinia-mutica-induce-cell-death-via-uck2-enzyme-inhibition-and-in-turn-reduce-18s-rrna-biosynthesis-in-ht-29-cells
#11
Ibrahim Malami, Ahmad Bustamam Abdul, Rasedee Abdullah, Nur Kartinee Bt Kassim, Rozita Rosli, Swee Keong Yeap, Peter Waziri, Imaobong Christopher Etti, Muhammad Bashir Bello
Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of cancer. Due to the selective expression of UCK2 in cancer cells, a selective inhibition of this key enzyme necessitates the discovery of its potential inhibitors for cancer chemotherapy. The present study was carried out to demonstrate the potentials of natural phytochemicals from the rhizome of Alpinia mutica to inhibit UCK2 useful for colorectal cancer. Here, we employed the used of in vitro to investigate the effectiveness of natural UCK2 inhibitors to cause HT-29 cell death...
2017: PloS One
https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#12
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101713/macro-and-microelement-content-and-other-properties-of-chaenomeles-japonica-l-fruit-and-protective-effects-of-its-aqueous-extract-on-hepatocyte-metabolism
#13
Irena Baranowska-Bosiacka, Beata Bosiacka, Julita Rast, Izabela Gutowska, Jolanta Wolska, Ewa Rębacz-Maron, Kamila Dębia, Katarzyna Janda, Jan Korbecki, Dariusz Chlubek
This growing interest in the cultivation of Japanese quince Chaenomeles japonica L. results from the potentially beneficial properties of its fruit. Fresh fruits are very firm and too acidic to eat raw, but their bioactive components, distinctive aroma, and high amount of dietary fiber make the fruits well suited for industrial processing. However, not all the properties of the fruit have been investigated. For example, there are no comprehensive reports about the mineral content or potentially harmful effects on liver metabolism...
January 18, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28100853/antioxidant-and-antimicrobial-properties-of-bioactive-phytochemicals-from-cranberry
#14
Monika Baranowska, Agnieszka Bartoszek
In the rational human diet, the important role of fruits and vegetables, which are a source of bioactive phytochemicals, is emphasized. Among fruits particular attention, due to a number of documented health-promoting properties, is focused on cranberry. This fruit is characterized by the high content of antioxidant phenolic compounds, which may support the natural antioxidant defense system of the body in the prevention of damage caused by oxidative stress induced by reactive oxygen species (ROS). Therefore, cranberry is suggested for the prevention of civilization diseases such as atherosclerosis, hypertension and cancer, whose etiology is associated directly with oxidative stress...
December 31, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28100844/phospholipids-and-products-of-their-hydrolysis-as-dietary-preventive-factors-for-civilization-diseases
#15
Karol Parchem, Agnieszka Bartoszek
The results of numerous epidemiological studies indicate that phospholipids play an important role in the prevention of chronic diseases faced by contemporary society. Firstly, these compounds are responsible for the proper functioning of cell membranes, by ensuring liquidity and permeability, which is pivotal for normal activity of membrane proteins, including receptors. These mechanisms are at the core of prevention of cancer, autoimmune or neurological disorders. Secondly, structure and properties of phospholipids cause that they are highly available source of biologically active fatty acids...
December 31, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28100224/radical-scavenging-activities-of-lagerstroemia-speciosa-l-pers-petal-extracts-and-its-hepato-protection-in-ccl4-intoxicated-mice
#16
Bipransh Kumar Tiwary, Somit Dutta, Priyankar Dey, Mossaraf Hossain, Anoop Kumar, Sony Bihani, Ashis Kumar Nanda, Tapas Kumar Chaudhuri, Ranadhir Chakraborty
BACKGROUND: Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts. METHODS: Several spectroscopic methods, including GC-MS, were used to characterize phytochemicals present in the petal extract of L...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28100074/antioxidant-capacity-and-identification-of-the-constituents-of-ethyl-acetate-fraction-from-rhus-verniciflua-stokes-by-hplc-ms
#17
Hongxia Chen, Chengzhang Wang, Hao Zhou, Ran Tao, Jianzhong Ye, Wenjun Li
Ethyl acetate fraction (EAF) from Rhus verniciflua Stokes is an important source of bioactive compounds. The aim of this study was the tentative identification and quantification of phenolic compounds, comparison of the phenolic structure-antioxidant activity relationships. Twelve compounds of EAF belonging to polyphenol types were detected by high performance liquid chromatography and analysed on line with negative ion electrospray ionisation tandem mass spectrometry, which were ethoxy 3-hydroxy benzoic acid, gallic acid (GA), 3,4-dihydroxy amygdalic acid, gallic acid cetyl ester, protocatechuic acid (PA), fustin, ethyl gallate (EG), garbanzol, fisetin, sulfuretin, butin and 3,7-dihydroxyflavanone-4'-rhamnoside...
January 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28099856/screening-bioactives-reveals-nanchangmycin-as-a-broad-spectrum-antiviral-active-against-zika-virus
#18
Keiko Rausch, Brent A Hackett, Nathan L Weinbren, Sophia M Reeder, Yoel Sadovsky, Christopher A Hunter, David C Schultz, Carolyn B Coyne, Sara Cherry
Zika virus is an emerging arthropod-borne flavivirus for which there are no vaccines or specific therapeutics. We screened a library of 2,000 bioactive compounds for their ability to block Zika virus infection in three distinct cell types with two different strains of Zika virus. Using a microscopy-based assay, we validated 38 drugs that inhibited Zika virus infection, including FDA-approved nucleoside analogs. Cells expressing high levels of the attachment factor AXL can be protected from infection with receptor tyrosine kinase inhibitors, while placental-derived cells that lack AXL expression are insensitive to this inhibition...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/28099003/-neocaryachine-an-antiproliferative-pavine-alkaloid-from-cryptocarya-laevigata-induces-dna-double-strand-breaks
#19
Yuki Suzuki, Yohei Saito, Masuo Goto, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Twelve benzylisoquinoline alkaloids, including pavine and phenanthroindolizidine types, were isolated from a MeOH/CH2Cl2 extract of Cryptocarya laevigata (stem bark) through bioactivity-guided fractionation for antitumor effects. Selected compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a multidrug-resistant subline. Since more common 2,3,8,9-tetrasubstituted pavine alkaloids, such as crychine (3), exhibit very mild or no cytotoxicity, this compound type has not been well investigated for antitumor activity...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28098940/characterization-of-date-deglet-nour-seed-free-and-bound-polyphenols-by-high-performance-liquid-chromatography-mass-spectrometry
#20
Sameera Sirisena, Dimitrios Zabaras, Ken Ng, Said Ajlouni
Date (Pheonix dactylifera L.) seeds are a valuable and abundant by-product with various potential food applications. Free polyphenols (FPPs) and bound polyphenols (BPPs) of date seeds from Deglet Nour variety grown in Australia were investigated using high-performance liquid chromatography-mass spectrometry. The FPP fraction contained the following main phenolic compounds per gram of date seed powder; procyanidin B1 (499.8 ± 7.8 μg), procyanidin B2 (288.6 ± 6.1 μg), catechin (167.6 ± 2.1 μg), epicatechin (39...
January 18, 2017: Journal of Food Science
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