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https://www.readbyqxmd.com/read/27888342/putting-recommendations-into-practice-australian-rheumatologists-opinions-on-leflunomide-use-in-rheumatoid-arthritis
#1
Ashley M Hopkins, Michael D Wiese, Catherine E O'Doherty, Susanna M Proudman
Leflunomide is the most recently introduced conventional disease-modifying anti-rheumatic drugs in Australia. It has several unique methods for initiation, unique monitoring recommendations and a distinctive cessation protocol in the event of serious toxicity. The aim of this study was to evaluate initiation and monitoring practices of Australian rheumatologists using leflunomide. A survey was emailed twice, approximately 3 months apart to 332 rheumatologist members of the Australian Rheumatology Association...
November 25, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27847520/a-complicated-course-of-acute-viral-induced-pharyngitis-icteric-hepatitis-acalculous-cholecystitis-and-skin-rash
#2
Fereshte Sheybani, HamidReza Naderi, Seddigheh Sadat Erfani, Masoumeh Gharib
This case reveals the complexities and challenges in the diagnosis of acute Epstein-Barr virus (EBV) infection, indicating the potential relationship between EBV infection and severe icteric hepatitis, acalculous cholecystitis, and lymphocytic vasculitis. We suggest including EBV infectious mononucleosis in the list of differential diagnoses when any of these clinical syndromes (or a combination thereof) occurs without apparent cause, especially in the presence of lymphocytosis. To our knowledge, this is the first report to suggest the possible role of EBV in the pathogenesis of cutaneous lymphocytic vasculitis...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27842627/polyarteritis-nodosa-presenting-as-a-bladder-outlet-obstruction
#3
M Borkum, H Y Abdelrahman, R Roberts, A A Kalla, I G Okpechi
Polyarteritis nodosa (PAN) of the urinary tract is rare. An unusual case of systemic PAN involving the bladder neck is described. A 27-year-old man, with known diastolic hypertension diagnosed 2 years earlier, was admitted with chronic urinary obstruction complicated by hydronephrosis. He had symptoms of myalgia and weight loss, was afebrile but had an elevated erythrocyte sedimentation rate and acute-on-chronic renal impairment. All virological and serological tests including hepatitis B and anti-neutrophil cytoplasmic antibody were negative...
November 2, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27761646/-viral-arthritis-and-vasculitis
#4
U Sixdorf, E Märker-Hermann
Viral arthritis and vasculitis are important differential diagnoses primarily in patients with acute polyarticular arthritis in association with fever and rash, in populations specially at risk and in returning travellers. Parvovirus B19 is the most frequent cause of viral arthritis in Europe, whereas rubella, hepatitis B and C viruses have become less common. Due to worldwide tourism arthritogenic alphaviruses, which are transmitted by mosquito vectors have come into the focus of tropical medicine and rheumatology...
October 19, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27721549/hepatic-and-hematological-adverse-effects-of-long-term-low-dose-methotrexate-therapy-in-rheumatoid-arthritis-an-observational-study
#5
Lily Dubey, Suparna Chatterjee, Alakendu Ghosh
OBJECTIVES: Methotrexate (MTX) is the most commonly used cost-effective disease-modifying antirheumatoid drug (DMARD). Its main dose-limiting adverse effects are hepatic and hematopoietic. This cross-sectional, observational study evaluated the prevalence of hepatic and hematological adverse effects with long-term low-dose MTX therapy. MATERIALS AND METHODS: Rheumatoid arthritis (RA) patients taking ≤15 mg/week MTX for at least 2 years were enrolled from the rheumatology outpatient department...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27709857/distribution-of-diseases-causing-liver-function-test-abnormality-in-children-and-natural-recovery-time-of-the-abnormal-liver-function
#6
Mirinae Jang, Min Su Oh, Se Cheol Oh, Ki Soo Kang
Although liver function test abnormality is frequently noted in children, there is no report about the distribution of the etiology and natural recovery time of the abnormal liver function. From March 2005 to February 2014, clinical information was retrospectively collected from 559 children who had abnormal liver function and were hospitalized or visited the outpatient clinic at the Jeju National University Hospital. The etiology of abnormal liver function was classified into groups and the natural recovery time of abnormal liver function was analyzed...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27708965/viral-hepatitis-screening-guideline-before-biological-drug-use-in-rheumatic-patients
#7
Ömer Karadağ, Timuçin Kaşifoğlu, Birol Özer, Sabahattin Kaymakoğlu, Yeşim Kuş, Murat İnanç, Gökhan Keser, Sedat Kiraz
Biological drugs (tumor necrosis factor inhibitors, rituximab, tocilizumab, abatacept, and tofacitinib) are important treatment alternatives in rheumatology, particularly for resistant patients. However, they may cause hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivation; for instance, HBV reactivation may occur in a patient who is an inactive hepatitis B surface antigen (HBsAg) carrier or who has resolved HBV infection. Therefore, the screening of patients before biological treatment and the application of a prophylactic treatment, particularly with respect to latent HBV infections, are recommended when necessary...
March 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27708953/current-antiviral-practice-and-course-of-hepatitis-b-virus-infection-in-inflammatory-arthritis-a-multicentric-observational-study-a-hbv-study
#8
Umut Kalyoncu, Hakan Emmungil, Ahmet Mesut Onat, Sedat Yılmaz, Timuçin Kaşifoglu, Servet Akar, Nevsun İnanç, Fatih Yıldız, Orhan Küçükşahin, Ömer Karadağ, Rıdvan Mercan, Cemal Bes, Veli Yazısız, Barış Yılmazer, Mustafa Özmen, Şükran Erten, Soner Şenel, Ayten Yazıcı, Koray Taşçılar, Melike Kalfa, Sedat Kiraz, Bünyamin Kısacık, Yavuz Pehlivan, Levent Kılıç, İsmail Şimşek, Ayşe Çefle, Nurullah Akkoç, Haner Direskeneli, Eren Erken, Murat Turgay, Mehmet Akif Öztürk, Mehmet Soy, Kenan Aksu, Ayhan Dinç, İhsan Ertenli
OBJECTIVE: The reactivation of hepatitis B virus (HBV) infection is a well-known event in hepatitis B surface antigen (HbsAg)-positive patients receiving immunosuppressive therapy. The objective of this study was to assess the antiviral practice and course of HBV infection in inflammatory arthritis. MATERIAL AND METHODS: Nineteen rheumatology centers participated in this retrospective study. HbsAg-positive patients who were taking disease-modifying antirheumatic drugs and who were being tested for HBV viral load at a minimum of two different time points were included...
December 2015: Eur J Rheumatol
https://www.readbyqxmd.com/read/27708728/hepatitis-b-serology-in-patients-with-rheumatic-diseases
#9
Martin Feuchtenberger, Arne Schäfer, Axel Philipp Nigg, Michael Rupert Kraus
BACKGROUND: Only limited data are available on the prevalence of hepatitis B in patients with proven rheumatic diseases and thus the risk of reactivation under immunosuppressive therapy. OBJECTIVE: To analyse hepatitis B serology in patients with rheumatic diseases prior to therapy. METHOD: In total, 1,338 patient records were analysed for HBsAg, HBsAb and HBcAb in a cross-sectional, single-centre study between 2011 and 2015 at first presentation...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27660934/safety-of-corticosteroid-treatment-in-rheumatologic-patients-with-markers-of-hepatitis-b-viral-infection-pilot-evaluation-study
#10
Yolanda Braun-Moscovici, Marius Braun, Tarek Saadi, Doron Markovits, Menahem A Nahir, Alexandra Balbir-Gurman
BACKGROUND: Immunosuppressive agents may induce hepatitis B flares. The minimal corticosteroid dose and duration of therapy leading to HBV reactivation is unknown. OBJECTIVE: To assess whether short-term corticosteroid therapy for rheumatologic diseases induces HBV reactivation. METHODS: The records of all HBsAg or HBcore antibodies positive, anti-HBs negative patients who were hospitalized in the rheumatology department during 2001-2014 and treated with corticosteroids were reviewed...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27660491/five-year-risk-of-hiv-diagnosis-subsequent-to-147-hospital-based-indicator-diseases-a-danish-nationwide-population-based-cohort-study
#11
Lars Haukali Omland, Rebecca Legarth, Magnus Glindvad Ahlström, Henrik Toft Sørensen, Niels Obel
BACKGROUND: It has been suggested that targeted human immunodeficiency virus (HIV) testing programs are cost-effective in populations with an HIV prevalence >0.1%. Several indicator diseases are known to be associated with increased risk of HIV infection, but estimates of HIV frequency in persons with relevant indicator diseases are nonexistent. METHODS: In a nationwide population-based cohort study encompassing all Danish residents aged 20-60 years during 1994-2013, we estimated the 5-year risk of an HIV diagnosis (FYRHD) after a first-time diagnosis of 147 prespecified potential indicator diseases...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27515671/the-use-of-cyclosporine-a-in-rheumatology-a-2016-comprehensive-review
#12
Cecilia Beatrice Chighizola, Voon H Ong, Pier Luigi Meroni
Cyclosporine A, an inhibitor of calcineurin, exerts an immunomodulator action interfering with T cell activation. Even though novel therapeutic tools have emerged, CyA still represents a suitable option in several clinical rheumatology settings. This is the case of refractory nephritis and cytopenias associated with systemic lupus erythematosus. Furthermore, CyA is a valued therapeutic tool in the management of uveitis and thrombophlebitis in course of Behçet's disease. Topical CyA has been proven to be beneficial in the dry eye of Sjogren's syndrome, whereas oral treatment with CyA can be considered for the severe complications of adult onset Still's disease...
August 11, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27465818/a-multicenter-randomized-double-blind-placebo-controlled-trial-evaluating-the-efficacy-and-safety-of-tong-luo-hua-shi-capsule-a-modernized-tibetan-medicine-in-patients-with-rheumatoid-arthritis
#13
Wei Liu, Yuan-Hao Wu, Si-Yuan Hu, Cheng-Liang Zhong, Ming-Li Gao, Dong-Wu Liu, Hai-Yun Wang, Mu-Zhi Chen, Yue-Jin Song, Ben-Zha-Xi Yang, Qing-Shan Zheng, Hua Yao, Xue-Bing Qi, Gang Li
BACKGROUND: Tong Luo Hua Shi (TLHS) is a new formulation of the traditional Tibetan medicine Wu-wei-gan-lu that has been used for the treatment of rheumatoid arthritis (RA) for hundreds of years in China. This study aimed to evaluate the efficacy and safety of TLHS in patients with RA. METHODS: This was a randomized, double-blind, placebo-controlled, dose-finding study performed in patients with active RA from five medical centers. Patients received three doses (4...
2016: Trials
https://www.readbyqxmd.com/read/27424016/secondary-sjogren-s-syndrome-in-83-patients-with-rheumatoid-arthritis
#14
Asghar Hajiabbasi, Irandokht Shenavar Masooleh, Yousef Alizadeh, Amir Sadredin Banikarimi, Pooneh Ghavidel Parsa
UNLABELLED: Sjogren syndrome (SS) can occur alone, primary Sjogren syndrome, or in association with other rheumatic diseases, secondary Sjogren syndrome (sSS), such as Rheumatoid arthritis (RA). The occurrence of Sjogren syndrome with RA makes it course worse and increases high morbidity and mortality of RA. In this exploratory study we aim to determine the prevalence of sSS (diagnosed based on the revised version of American-European consensus Group Classification Criteria: AUCG-criteria), sicca symptoms (dry eye, dry mouth), positive autoantibody tests (Anti RO or Anti-LA antibodies), UWSFR (Unstimulated Whole Salivary Flow Rate), Schirmer and Lissamine test...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27383049/safety-profile-of-repeated-rituximab-cycles-in-unselected-rheumatoid-arthritis-patients-a-long-term-prospective-real-life-study
#15
Dimitrios Vassilopoulos, Evie M Delicha, Loukas Settas, Alexandros Andrianakos, Spyros Aslanidis, Panagiota Boura, Marios Katsounaros, Panagiotis Athanassiou, Konstantinos Tempos, Grigorios Skarantavos, Christodoulos Antoniadis, Sotirios Papazoglou, Lazaros Sakkas, Vassiliki Galanopoulou, Fotini Skopouli, Kyriaki Boki, Dimitrios Daoussis, Eleni Vritzali, Petros P Sfikakis
OBJECTIVES: To evaluate the long-term safety of rituximab (RTX) in rheumatoid arthritis (RA) patients in daily clinical practice. METHODS: This was a multicentre (17 Greek Rheumatology sites), prospective, long-term, pharmacovigilance study of patients with moderate to severe RA and an inadequate response or intolerance to ≥1 anti-tumour necrosis factor (TNF) agents. Adverse events (AEs) were recorded and collected prospectively every 2-6 months. RESULTS: 234 patients (mean age: 59±12...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27348845/risk-factors-for-implant-failure-and-peri-implant-pathology-in-systemic-compromised-patients
#16
Joana Neves, Miguel de Araújo Nobre, Pedro Oliveira, José Martins Dos Santos, Paulo Malo
PURPOSE: To identify the possible risk factors for implant failure and peri-implant pathology in a population of systemically compromised patients. MATERIALS AND METHODS: This retrospective clinical study included a total of 721 systemically compromised patients (422 women, 299 men), with an average age of 51 years (range: 20 to 87) rehabilitated with dental implants. The average follow-up time was 7.3 years. The patients' demographic variables (age and gender) and clinical variables (implant location, type of implant surface, and systemic conditions) were recorded...
June 27, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27338104/immunoglobulin-g-levels-as-a-prognostic-factor-for-autoimmune-hepatitis-combined-with-systemic-lupus-erythematosus
#17
Doo-Ho Lim, Yong-Gil Kim, Danbi Lee, Soo Min Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo
OBJECTIVE: Autoimmune hepatitis (AIH) is a chronic progressive liver disease characterized by circulating autoantibodies and hyperglobulinemia. This study was conducted to identify the features of AIH accompanied by systemic lupus erythematosus (SLE-AIH) that differ from those of primary AIH (P-AIH), and to evaluate factors that affect the outcome for SLE-AIH patients. METHODS: From May 1995 to April 2014, clinical data (including liver pathology) from 164 patients with P-AIH and 23 patients with SLE-AIH were collected from an electronic database at a tertiary referral center...
July 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27335709/retinopathy-and-uveitis-associated-with-sofosbuvir-therapy-for-chronic-hepatitis-c-infection
#18
Katrina Chin-Loy, Farah Galaydh, Saad Shaikh
PURPOSE: We report a case of retinopathy and uveitis associated with sofosbuvir therapy for hepatitis C infection. METHODS: Case report. RESULTS: A 57-year-old-male developed ocular inflammation and retinopathy four weeks after the administration of sofosbuvir for a hepatitis C infection. Hearing loss, rheumatologic disease, and essential tremor were also noted. The ophthalmic findings resolved with discontinuation of the drug.    CONCLUSION:  The authors report a case of sofosbuvir induced retinopathy and uveitis, the first associated with this emerging therapy for hepatitis C...
May 3, 2016: Curēus
https://www.readbyqxmd.com/read/27311193/-rheumatoid-arthritis-and-viral-hepatitis
#19
REVIEW
Hiroko Kobayashi, Hiroshi Watanabe, Hiromasa Ohira
Hepatitis B virus (HBV) reactivation during immunosuppressive therapy is responsible for severe liver injuries in patients with persistent HBV infection. Serological examination for HBV infection is necessary before starting immunosuppressive therapy for all patients with rheumatoid arthritis. Japanese College of Rheumatology recommends that all patients should be screened for HBs antigen before immunosuppressive therapy. Then those who are negative for HBs antigen should be tested for anti-HBs and anti-HBc antibodies...
June 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27078247/-xanthinuria-type-1-in-a-woman-with-arthralgias-a-combined-clinical-and-molecular-genetic-investigation
#20
Roland Wolfgang Därr, Steffen Lenzner, Thomas Eggermann, Wolfgang Hermann Därr
HISTORY AND CLINICAL PRESENTATION: A 53-year old woman with recurrent polyarthralgias, negative test results in a recent rheumatologic work-up and an unmeasurably low uric acid serum concentration presented for suspected IgM paraproteinemia. INVESTIGATIONS: Physical examination, abdominal ultrasound and routine laboratory test results were unremarkable. Repeat determination confirmed a markedly decreased uric acid (UA) serum concentration. Urinary xanthine and hypoxanthine concentrations were increased by 14-fold and 7...
April 2016: Deutsche Medizinische Wochenschrift
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