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JOURNAL ARTICLE
Dariusz Zieliński, Szymon Darocha, Arkadiusz Pietrasik, Michał Machowski, Krzysztof Wróbel, Marcin Kurzyna, Piotr Pruszczyk, Adam Torbicki, Andrzej Biederman
BACKGROUND: This study aimed to assess the prevalence of chronic thromboembolic lesions in the pulmonary arteries among patients undergoing pulmonary embolectomy for acute pulmonary embolism and their impact on treatment outcomes. METHODS: We conducted a retrospective, single-center analysis of consecutive patients undergoing emergency pulmonary embolectomy for acute pulmonary embolism between 2013 and August 2021. According to European Society of Cardiology guidelines, the diagnosis was based on clinical presentation, imaging studies and laboratory tests...
April 18, 2024: Journal of Cardiovascular Surgery
#2
JOURNAL ARTICLE
Hitoshi Iwasaki, Hideo Uehara, Yugo Fujimoto, Hirofumi Hasuda, Eiji Kusumoto, Yuichi Hisamatsu, Rintaro Yoshida, Yoshihisa Sakaguchi, Tetsuya Kusumoto
BACKGROUND: Portal vein thrombosis (PVT) and venous thromboembolism (VTE) both result from partial or complete occlusion of a blood vessel by a blood clot. The prognosis of PVT is generally good; however, PVT with VTE, including pulmonary embolism (PE), has a high mortality rate. We report here a case of PE after surgery for small intestinal necrosis caused by idiopathic PVT. CASE PRESENTATION: A 69-year-old female attended our hospital with a chief complaint of upper abdominal discomfort, and was diagnosed with necrosis of the small intestine as a result of unexplained PVT...
April 18, 2024: Surgical Case Reports
#3
JOURNAL ARTICLE
Aishwarya Anand, Naveen C Hegde, Pulkit Chhabra, Jai Purohit, Rupesh Kumar, Ankur Gupta, Deepesh P Lad, Ritin Mohindra, Saurabh Mehrotra, Rajesh Vijayvergiya, Basant Kumar, Vishal Sharma, Pankaj Malhotra, Jasmina Ahluwalia, Reena Das, Amol N Patil, Nusrat Shafiq, Samir Malhotra
BACKGROUND: Empirical use of pharmacogenetic test(PGT) is advocated for many drugs, and resource-rich setting hospitals are using the same commonly. The clinical translation of pharmacogenetic tests in terms of cost and clinical utility is yet to be examined in hospitals of low middle income countries (LMICs). AIM: The present study assessed the clinical utility of PGT by comparing the pharmacogenetically(PGT) guided- versus standard of care(SOC)- warfarin therapy, including the health economics of the two warfarin therapies...
April 18, 2024: Annals of Hematology
#4
JOURNAL ARTICLE
Justin E Vranic, Adam A Dmytriw, Inka K Berglar, Naif M Alotaibi, Nicole M Cancelliere, Christopher J Stapleton, James D Rabinov, Pablo Harker, Rajiv Gupta, Joshua D Bernstock, Matthew J Koch, Scott B Raymond, Justin R Mascitelli, T Tyler Patterson, Joshua Seinfeld, Andrew White, David Case, Christopher Roark, Chirag D Gandhi, Fawaz Al-Mufti, Jared Cooper, Charles Matouk, Nanthiya Sujijantarat, Diego A Devia, Maria I Ocampo-Navia, Daniel E Villamizar-Torres, Juan C Puentes, Mohamed M Salem, Ammad Baig, Kareem El Namaani, Anna Luisa Kühn, Bryan Pukenas, Brian T Jankowitz, Jan Karl Burkhardt, Adnan Siddiqui, Pascal Jabbour, Jasmeet Singh, Ajit S Puri, Robert W Regenhardt, Vitor Mendes Pereira, Aman B Patel
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using pipeline embolization device (PED). We aimed to assess the impact of platelet function testing (PFT) on reducing periprocedural thromboembolic complications associated with PED flow diversion in patients receiving aspirin and clopidogrel. METHODS: Patients with unruptured intracranial aneurysms requiring PED flow diversion were identified from 13 centers for retrospective evaluation...
April 18, 2024: Neurosurgery
#5
Daniel Edward Horner, Sarah Davis, Abdullah Pandor, Helen Shulver, Steve Goodacre, Daniel Hind, Saleema Rex, Michael Gillett, Matthew Bursnall, Xavier Griffin, Mark Holland, Beverley Jane Hunt, Kerstin de Wit, Shan Bennett, Robin Pierce-Williams
BACKGROUND: Pharmacological prophylaxis during hospital admission can reduce the risk of acquired blood clots (venous thromboembolism) but may cause complications, such as bleeding. Using a risk assessment model to predict the risk of blood clots could facilitate selection of patients for prophylaxis and optimise the balance of benefits, risks and costs. OBJECTIVES: We aimed to identify validated risk assessment models and estimate their prognostic accuracy, evaluate the cost-effectiveness of different strategies for selecting hospitalised patients for prophylaxis, assess the feasibility of using efficient research methods and estimate key parameters for future research...
April 2024: Health Technology Assessment: HTA
#6
Juan D Ayala Torres, Santiago Andrés Gómez Salazar, Juan Gonzalo Vélez Zuluaga
The presented case describes a 56-year-old male with adult-onset Still's disease, exhibiting polyserositis in 2019, who underwent pleurectomy and pericardiectomy. Despite treatment with tocilizumab and methylprednisolone, the patient developed deep vein thrombosis and pulmonary embolism in 2022, managed with apixaban. A contrast-enhanced chest tomography revealed no recurrent thromboembolic events. Over a year, the patient experienced progressive dyspnea, correlating with signs of constriction on transthoracic echocardiogram...
March 2024: Curēus
#7
Priya Garg, Kshitiz Lakhey, Nishtha Mishra, Yash Buccha, Kirti S Deo
Pemphigus vulgaris is a chronic autoimmune disease of the skin caused by the production of autoantibodies targeting desmogleins 1 and 3 usually presenting in individuals with an average age of onset of approximately 40 years. A 35-year-old obese, diabetic woman presented with fluid-filled lesions over her body for three months along with erosions and painful ulcers in her mouth and genital area for two months. Based on clinical and histopathological studies, the patient was diagnosed as a case of pemphigus vulgaris...
March 2024: Curēus
#8
JOURNAL ARTICLE
Aaron A Gurayah, Ruben Blachman-Braun, Christopher J Machado, Matthew M Mason, Helen Y Hougen, Ali Mouzannar, Mark L Gonzalgo, Bruno Nahar, Sanoj Punnen, Dipen J Parekh, Chad R Ritch
OBJECTIVES: The objective of this study is to investigate the association between major adverse cardiac events (MACE) and clinical factors of patients undergoing radical cystectomy (RC) for bladder cancer. MATERIALS AND METHODS: A retrospective analysis using the 2015-2020 National Surgical Quality Improvement Program database was performed on patients who underwent RC for bladder cancer. MACE was defined as any report of cerebrovascular accident, myocardial infarction, or thromboembolic events (pulmonary embolism or deep vein thrombosis)...
April 2024: BJUI compass
#9
MULTICENTER STUDY
Xiaolan Chen, Hongning Shi, Jiaqi Chang, Wenjia Guo, Yuanhua Yang, Yong Wang, Lei Pan
To external validate the risk assessment model (RAM) of venous thromboembolism (VTE) in multicenter internal medicine inpatients. We prospectively collected 595 internal medical patients (310 with VTE patients, 285 non-VTE patients) were from Beijing Shijitan Hospital, Beijing Chaoyang Hospital, and the respiratory department of Beijing Tsinghua Changgeng Hospital from January 2022 to December 2022 for multicenter external validation. The prediction ability of Caprini RAM, Padua RAM, The International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) RAM, and Shijitan (SJT) RAM were compared...
2024: Clinical and Applied Thrombosis/hemostasis
#10
JOURNAL ARTICLE
Mirjana Mitrovic, Nikola Pantic, Zoran Bukumiric, Nikica Sabljic, Marijana Virijevic, Zlatko Pravdic, Mirjana Cvetkovic, Nikola Ilic, Jovan Rajic, Milena Todorovic-Balint, Ana Vidovic, Nada Suvajdzic-Vukovic, Jecko Thachil, Darko Antic
BACKGROUND: Patients with acute myeloid leukemia (AML) are at increased risk of venous thromboembolic events (VTE). However, thromboprophylaxis is largely underused. OBJECTIVES: This study aimed to determine possible VTE development risk factors and to develop a novel predictive model. METHODS: We conducted a retrospective cohort study of adult patients with newly diagnosed AML. We used univariate and multivariable logistic regression to estimate binary outcomes and identify potential predictors...
April 17, 2024: Thrombosis Journal
#11
REVIEW
Olivier Sanchez, Pierre-Marie Roy, Yoann Gaboreau, Jeannot Schmidt, Farès Moustafa, Asmahane Benmaziane, Antoine Élias, Olivier Espitia, Marie-Antoinette Sevestre, Francis Couturaud, Isabelle Mahé
Patients hospitalised with acute venous thromboembolism (VTE), and notably patients with pulmonary embolism, often remain in hospital for extended periods due to the perceived risk of complications. However, several studies have shown that home treatment of selected patients is feasible and safe, with a low incidence of adverse events. This may offer clear benefits for patients' quality of life, hospital planning and cost to the health service. Nonetheless, there is a need for a VTE risk-stratification tool specifically addressing prognosis in patients with cancer...
April 16, 2024: La Revue de Médecine Interne
#12
J D Oleas Quezada, J A Coyago Iñiguez, E R Guerrero Cevallos
This case report examines peripartum cardiomyopathy (PPCM), a rare variant of heart failure with reduced ejection fraction, which manifests at the end of labor or puerperium. The frequency of this pathology varies globally, and its association with risk factors such as genetic disorders, autoimmune diseases, viral infections, suggests a multifactorial etiology. Diagnostic criteria include: Heart failure secondary to left ventricular systolic dysfunction, manifested in the puerperium or at the end of pregnancy and lack of other identifiable causes of heart failure...
April 16, 2024: Hipertensión y Riesgo Vascular
#13
JOURNAL ARTICLE
Pearl L H Mok, Matthew J Carr, Bruce Guthrie, Daniel R Morales, Aziz Sheikh, Rachel A Elliott, Elizabeth M Camacho, Tjeerd van Staa, Anthony J Avery, Darren M Ashcroft
OBJECTIVE: To investigate risks of multiple adverse outcomes associated with use of antipsychotics in people with dementia. DESIGN: Population based matched cohort study. SETTING: Linked primary care, hospital and mortality data from Clinical Practice Research Datalink (CPRD), England. POPULATION: Adults (≥50 years) with a diagnosis of dementia between 1 January 1998 and 31 May 2018 (n=173 910, 63.0% women)...
April 17, 2024: BMJ: British Medical Journal
#14
JOURNAL ARTICLE
Zhihai Huang, Zhenzhen Zheng, Lingpin Pang, Kaili Fu, Junfen Cheng, Ming Zhong, Lingyue Song, Dingyu Guo, Qiaoyun Chen, Yanxi Li, Yongting Lv, Riken Chen, Xishi Sun
Background Despite previous observational studies linking obstructive sleep apnea (OSA) to venous thromboembolism (VTE), these findings remain controversial. This study aimed to explore the association between OSA and VTE, including pulmonary embolism (PE) and deep vein thrombosis (DVT), at a genetic level using a bidirectional two-sample Mendelian randomization (MR) analysis. Methods Utilizing summary-level data from large-scale genome-wide association studies (GWAS) in European individuals, we designed a bidirectional two-sample MR analysis to comprehensively assess the genetic association between OSA and VTE...
April 17, 2024: Thrombosis and Haemostasis
#15
JOURNAL ARTICLE
Natalia Calvo-Sánchez, Álex Gómez, Estela Pérez, María Borobia, Lluís Luján, Antonio Fernández, Sergio Villanueva-Saz, Maite Verde, Diana Marteles
Canine leishmaniosis is a vector-borne disease caused by Leishmania infantum, and clinical manifestations of infection range from absent or severe to fatal and result from immune-mediated mechanisms. In dogs, the most common clinical signs of leishmaniosis include skin lesions and lymphadenomegaly. However, the presence of other nontypical signs has been described, and diagnosing these cases can be challenging. The aim of the present short communication was to describe the impact of the formation of circulating immunocomplexes due to L...
April 17, 2024: Veterinary Research Communications
#16
REVIEW
Charalampos Charalampous, Darshi Shah, Shaji Kumar, Rajshekhar Chakraborty
Venous thromboembolism (VTE) poses a significant challenge in the context of multiple myeloma, with an incidence of up to 10% in newly diagnosed patients and varying frequency in the relapsed/refractory setting. Accurate VTE risk assessment and personalized thromboprophylaxis strategies are important parts of supportive care in myeloma. There are three validated risk assessment models for prediction of VTE risk in newly diagnosed myeloma-SAVED, IMPEDE-VTE, and PRISM. In this review, we delve into the practical applications of VTE risk prediction models in the context of current therapies...
April 17, 2024: Annals of Hematology
#17
JOURNAL ARTICLE
Justine Herndon, Nidhi Gupta, Caroline Davidge-Pitts, Nicole Imhof, Cesar Gonzalez, Sara Carlson, Marissa Will, Jorys Martinez-Jorge, Vahe Fahradyan, Lily Tamire, Anna Lin, Todd B Nippoldt, Alice Y Chang
CONTEXT: Transgender and gender diverse (TGD) individuals have greater access to genital surgery (GS) with improved insurance coverage and access to trained surgeons and interdisciplinary gender affirming providers. OBJECTIVE: To determine perioperative medical and behavioral health outcomes in transfeminine (TF) individuals undergoing GS with use of a specific gender-affirming hormone therapy (GAHT) algorithm based on individualized risk factor assessment. DESIGN: Retrospective observational cohort study from 2017-2022...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
#18
JOURNAL ARTICLE
Visual functions, ocular characteristics and visual quality of life in patients with homocystinuria.
Aran Koye, Mattias Nilsson, David Epstein, Mikael Oscarson, Kristina Teär Fahnehjelm
BACKGROUND: Homocystinuria (HCU) is a rare metabolic disease that affects many organs, including the eyes. Aims: to assess visual functions, ocular characteristics, visual quality of life and time from the onset of ocular manifestations to HCU-diagnosis in patients with HCU. MATERIAL AND METHODS: Eighteen patients underwent ophthalmological examinations and visual quality of life questionnaires. RESULTS: Best corrected decimal visual acuity was median 1...
April 17, 2024: Ophthalmic Genetics
#19
JOURNAL ARTICLE
Chloe A Mutimer, Bruce C V Campbell
No abstract text is available yet for this article.
April 17, 2024: Stroke; a Journal of Cerebral Circulation
#20
JOURNAL ARTICLE
Isaac J Ergas, Richard K Cheng, Janise M Roh, Lawrence H Kushi, Jacob K Kresovich, Carlos Iribarren, Mai Nguyen-Huynh, Jamal S Rana, Eileen Rillamas-Sun, Cecile A Laurent, Valerie S Lee, Charles P Quesenberry, Heather Greenlee, Marilyn L Kwan
BACKGROUND: Women with breast cancer are at higher risk of cardiovascular disease (CVD) compared with women without breast cancer. Whether higher diet quality at breast cancer diagnosis lowers this risk remains unknown. We set out to determine if higher diet quality at breast cancer diagnosis was related to lower risk of CVD and CVD-related death. METHODS: This analysis included 3415 participants from the Pathway Study, a prospective cohort of women diagnosed with invasive breast cancer at Kaiser Permanente Northern California between 2005 and 2013 and followed through December 31, 2021...
February 29, 2024: JNCI Cancer Spectrum
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